CN111437361A - Plaster for treating lumbar intervertebral disc protrusion and preparation method thereof - Google Patents

Plaster for treating lumbar intervertebral disc protrusion and preparation method thereof Download PDF

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CN111437361A
CN111437361A CN202010371107.2A CN202010371107A CN111437361A CN 111437361 A CN111437361 A CN 111437361A CN 202010371107 A CN202010371107 A CN 202010371107A CN 111437361 A CN111437361 A CN 111437361A
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parts
plaster
intervertebral disc
lumbar intervertebral
root
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郜占稳
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/62Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/21Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/486Millettia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/58Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/716Clematis (leather flower)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/89Cyperaceae (Sedge family)
    • A61K36/8905Cyperus (flatsedge)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9066Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease

Abstract

The invention discloses a plaster for treating lumbar intervertebral disc protrusion and a preparation method thereof, wherein the plaster is prepared from the following traditional Chinese medicine raw materials in parts by weight: 90-150 parts of ligusticum chuanxiong hort, 45-90 parts of szechwan chinaberry fruit, 60-120 parts of moutan bark, 90-150 parts of suberect spatholobus stem, 60-90 parts of nutgrass galingale rhizome, 60-90 parts of clematis root, 30-90 parts of turmeric root-tuber, 90-150 parts of salvia miltiorrhiza, 15-90 parts of liquorice, 45-90 parts of medicinal cyathula root and 15-30 parts of leech. Aiming at the syndrome of qi-stagnation and blood stasis type lumbar intervertebral disc protrusion, the invention takes the functions of promoting blood circulation by removing blood stasis and promoting qi circulation by relieving pain as the rules of treatment, adopts the formula principles of promoting blood circulation by removing blood stasis and promoting qi circulation by relieving pain, selects authentic medicinal materials, is reasonably compatible, and has extremely strong curative effect on qi-stagnation and blood stasis type lumbar intervertebral disc protrusion.

Description

Plaster for treating lumbar intervertebral disc protrusion and preparation method thereof
Technical Field
The invention relates to a traditional Chinese medicine, in particular to a plaster for treating lumbar disc herniation and a preparation method thereof.
Background
Lumbar intervertebral disc protrusion is one of the most common diseases in clinic, and belongs to the category of lumbago in traditional Chinese medicine. The causes of the lumbar intervertebral disc protrusion are various, and trauma, strain, wind cold, damp heat, liver and kidney deficiency and the like are all causes of the lumbar intervertebral disc protrusion. According to the etiology and pathogenesis of the lumbar intervertebral disc, the lumbar intervertebral disc protrusion is classified into the types of rheumatism obstruction, cold-dampness obstruction, qi stagnation and blood stasis and the like in traditional Chinese medicine. At present, the treatment medicines for treating the protrusion of the lumbar intervertebral disc are various in types, but most medicines are not classified into types, or have little curative effect, or have no obvious curative effect on diseases with certain symptoms. Moreover, if the medicine is not taken correctly, the disease condition can be delayed and even the aggravation of the disease condition is easy to occur.
Disclosure of Invention
Aiming at the defect of indefinite treatment of symptoms in the prior art, the invention provides a novel traditional Chinese medicine composition, and the plaster has the advantages of quick response, high cure rate, no toxic or side effect on human bodies, and good market popularization value.
The technical scheme of the invention is realized as follows: a plaster for treating lumbar intervertebral disc protrusion is prepared from the following traditional Chinese medicine raw materials in parts by weight: 90-150 parts of ligusticum chuanxiong hort, 45-90 parts of szechwan chinaberry fruit, 60-120 parts of moutan bark, 90-150 parts of suberect spatholobus stem, 60-90 parts of nutgrass galingale rhizome, 60-90 parts of clematis root, 30-90 parts of turmeric root-tuber, 90-150 parts of salvia miltiorrhiza, 15-90 parts of liquorice, 45-90 parts of medicinal cyathula root and 15-30 parts of leech.
The technical scheme of the invention can be realized as follows:
a plaster for treating lumbar intervertebral disc protrusion is prepared from the following medicines in parts by weight: 120 parts of ligusticum chuanxiong hort, 60 parts of szechwan chinaberry fruit, 90 parts of tree peony bark, 120 parts of suberect spatholobus stem, 75 parts of nutgrass galingale rhizome, 75 parts of clematis root, 60 parts of turmeric root-tuber, 120 parts of salvia miltiorrhiza, 60 parts of liquorice, 60 parts of medicinal cyathula root and 21 parts of leech.
The preparation method of the traditional Chinese medicine comprises the following steps:
step 1: processing the above medicines according to an ancient method, putting the processed medicines into a container, and mixing the medicines with oil 1: 3, pouring the sesame oil and the medicines in the container together according to the weight ratio, and soaking the medicines for several days according to the principles of summer three, autumn five and winter ten for later use;
step 2: pouring the standby medicine and the oil into a copper pot, decocting for 1 hour by small fire (200 ℃), then frying the medicine by big fire (280-;
and step 3: weighing the weight of the medicinal oil, boiling in a pot, adding 240 g of Plumbum Preparatium into each kilogram of medicinal oil as a basic standard, boiling with slow fire, carefully observing, carefully testing with water, and immediately taking the pot out of the fire when the plaster is picked up by a wooden stick and dropped into water to form a mass and fall to the bottom, thus obtaining the plaster;
and 4, step 4: stopping heating for about 20 min, soaking in cold water for 5-7 days, changing water for several times, taking out the plaster, air drying to remove water, and storing;
and 5: according to the dosage at any time, the plaster blocks are put in a pot to be heated to soften, and then the plaster blocks can be processed into finished plasters with different types.
The pharmacology of each specific medicinal component is as follows:
ligusticum wallichii: pungent and warm in property, activate blood and move qi, dispel wind and alleviate pain. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal pain, pricking pain in chest and hypochondrium, traumatic injury, swelling and pain, headache, and rheumatalgia.
Toosendan fruit: bitter and cold; has little toxicity. Soothing liver, moving qi, alleviating pain, expelling parasites. Can be used for treating chest and hypochondrium, abdominal distention and pain, hernia pain, and abdominal pain due to parasitic infestation.
Moutan bark: bitter, pungent and slightly cold. Clear heat and cool blood, activate blood and resolve stasis. Can be used for treating toxic heat, speckle, hematemesis, epistaxis, nocturnal fever, morning cool, anhidrosis, amenorrhea, dysmenorrhea, carbuncle, swelling, sore, traumatic injury, and pain.
Caulis spatholobi: bitter, sweet and warm. Tonify blood, activate blood and dredge collaterals. Can be used for treating menoxenia, blood deficiency, sallow complexion, numbness, paralysis, and rheumatalgia.
Rhizoma cyperi: pungent, slightly bitter, slightly sweet and neutral. Move qi and relieve depression, regulate menstruation and alleviate pain. Can be used for treating stagnation of qi due to stagnation of liver-qi, chest pain, hypochondrium pain, abdominal distention and pain, dyspepsia, chest and abdominal distention and fullness, hernia due to cold, abdominal pain, breast pain, menoxenia, amenorrhea, and dysmenorrhea.
Clematis root: pungent, salty and warm. Dispel wind and dampness, dredge collaterals and alleviate pain. Can be used for treating rheumatic arthralgia, numbness of limbs, spasm of muscles and tendons, difficulty in flexion and extension, and choking throat.
Turmeric root-tuber: pungent, bitter and cold. Move qi and remove blood stasis, clear heart fire and relieve depression, promote bile flow and cure jaundice. Can be used for treating amenorrhea, dysmenorrhea, chest and abdomen distention and pain, pricking pain, fever unconsciousness, epilepsy, jaundice, and dark urine.
Red sage root: bitter and slightly cold. Dispel stasis and alleviate pain, activate blood and dredge meridians, clear heart fire and relieve restlessness. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal mass, thoracico-abdominal pain, arthralgia due to heat, pyocutaneous disease, swelling and pain, vexation, and insomnia; hepatosplenomegaly, angina pectoris.
Licorice root: sweet and neutral. Invigorating spleen and replenishing qi, clearing away heat and toxic material, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the drugs. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature.
Radix cyathulae: sweet, slightly bitter and neutral. Dispel stasis, dredge meridians, dredge joints, induce diuresis and treat stranguria. Can be used for treating amenorrhea, abdominal mass, retention of exocytosis, arthralgia, flaccidity of feet, spasm of tendons, stranguria with hematuria and blood, and traumatic injury.
Leech: salty, bitter and neutral; has little toxicity. Break blood, dispel stasis and dredge meridians. Can be used for treating abdominal mass, amenorrhea due to blood stasis, traumatic injury.
According to modern pharmacological research:
ligusticum wallichii: the ligustrazine prolongs platelet aggregation time induced by ADP in vitro, and has depolymerization effect on aggregated platelets. Szechwan lovastatin affects platelet function and thrombosis probably by regulating the balance of TXA2/PGI2, and inhibits the synthesis of TXA2, and it was found that in platelet rich plasma, the platelet aggregation caused by TXA2 is significantly inhibited after the addition of the Szechwan lovastatin. The ligustrazine has effects of increasing surface charges of erythrocyte and platelet, reducing blood viscosity, and improving blood rheology. It has also been found that ligustrazine has urokinase activity and can directly activate plasminogen, but has no fibrinolytic activity. Chuanqiong can increase cAMP content in blood plasma of mice, thus affecting cell metabolism and increasing physiological function.
Toosendan fruit: the fructus toosendan and rhizoma cyperi can improve the effects of promoting qi circulation and relieving pain.
Moutan bark: the paeonol and other glycosides have antiinflammatory effect; the methanol extract of cortex moutan has platelet inhibiting effect; paeonol has central inhibitory effect on tranquilizing mind, lowering temperature, relieving fever, relieving pain, relieving spasm, etc., and has effects of resisting atherosclerosis, diuresis, and ulcer.
Caulis spatholobi: the caulis Spatholobi has blood vessel dilating effect, 20mg/kg of caulis Spatholobi water extract ethanol precipitation preparation is directly injected into femoral artery, and femoral artery blood flow is increased by 42.7% within 10 minutes after injection; the value is increased by 133% at the peak value; vascular resistance decreased by 45.3%.
Rhizoma cyperi: the analgesic effect is achieved by injecting 30g/kg water extraction and alcohol precipitation solution of rhizoma Cyperi into abdominal cavity of female mouse, measuring pain threshold of mouse by hot plate method, and comparing analgesic effects of various rhizoma Cyperi preparata. The results show that the raw rhizoma cyperi and the prepared rhizoma cyperi have the effect of improving the pain threshold of mice, wherein the best method is the improved Shanghai method which is inferior to the pharmacopoeia method (according to the Chinese pharmacopoeia 1977 edition, but 30kg of rice vinegar is added to every 100kg of rhizoma cyperi after slicing, the mixture is stirred and completely absorbed and then is stewed for 2 hours and dried).
Clematis root: the Chinese clematis root decoction (the variety is not identified) has analgesic effect, and the abdominal injection of 0.025 g/10 g (the minimum lethal dose of 1/8) can slightly improve the pain valve of a mouse (hot plate method), so the Chinese clematis root decoction has analgesic effect.
Turmeric root-tuber: the influence on blood rheology and the obvious influence of the curcumol extract on fibrinogen, and the blood activating effect of the curcumol extract is related to the reduction of the fibrinogen content in plasma.
Red sage root: the Saviae Miltiorrhizae radix has effects of dilating coronary artery, increasing coronary blood flow, relieving myocardial ischemia injury degree, accelerating myocardial ischemia or injury recovery, reducing myocardial infarction range, improving anoxia resistance, and protecting anoxia myocardium. Can improve microcirculation, promote blood flow rate, dilate blood vessel, and lower blood pressure. Can improve blood rheological property, reduce blood viscosity, inhibit blood coagulation, activate plasmin, inhibit platelet aggregation and adhesion, and resist thrombosis. Saviae Miltiorrhizae radix has protective effect on cerebral ischemia, and has tranquilizing, analgesic, hypnotic, and anticonvulsive effects.
Licorice root: glycyrrhizin or its calcium salt has strong detoxifying effect on white larynx toxin and tetanus toxin, and also has detoxifying effect on some allergic diseases, animal experimental hepatitis, tetrodotoxin and snake venom. The detoxification mechanism may be multifaceted, and the detoxification function of the liver is enhanced through precipitation, adsorption and combination in physical and chemical modes, and the hydrolysate glucuronic acid of glycyrrhizin is also an effective component of detoxification.
Radix cyathulae: contains alkaloid, and can separate out various insect metamorphotic steroids such as Huai amaranthone and herba Anthragmatis sterone. Has the functions of dispelling wind, promoting diuresis, dredging channels and promoting blood circulation.
Leech: 4 hours after 0.45g/kg of leech aqueous extract is subjected to intragastric administration and 7 days after continuous intragastric administration, the hirudo aqueous extract has a remarkable inhibiting effect on platelet aggregation of ADP-induced rats, can reduce the specific viscosity of whole blood and the specific viscosity of plasma, and shortens the electrophoresis time of red blood cells; in vitro tests show that 200mg/ml, 100mg/ml and 50mg/ml of the leech aqueous extract also has obvious inhibition effect on platelet aggregation of healthy human. Hirudin is a thrombin inhibitor, and contains 10-400 antithrombin units per mg of hirudin; hirudin has effect in preventing thrombosis of rat caused by bacterial endotoxin, and can reduce death rate of rat; hirudin also has effect in resisting in vitro frog heart contraction force enhancement caused by thrombin.
The formula principle of the invention is as follows: the invention takes blood circulation promoting, blood stasis removing, qi circulation promoting and pain relieving as treatment principles, uses ligusticum chuanxiong hort as a monarch drug, cortex moutan radicis and fructus toosendan as ministerial drugs, caulis spatholobi, rhizoma cyperi, radix clematidis, radix curcumae, salvia miltiorrhiza and leech as adjuvant drugs, and liquorice and radix cyathulae as guiding drugs.
The compatibility relationship of the invention is as follows: the ligusticum wallichii is a monarch drug in the prescription, and the ligusticum wallichii is capable of activating blood and promoting qi circulation, and dispelling wind and relieving pain, which embodies the treatment rules of activating blood and dissolving stasis, and promoting qi circulation and relieving pain of the prescription; cortex moutan and fructus toosendan are ministerial drugs, cortex moutan assists the blood circulation promoting effect of the monarch drug rhizoma ligustici chuanxiong, and the effect of promoting blood circulation and removing blood stasis is achieved in the prescription, and fructus toosendan assists the qi circulation promoting effect of the monarch drug rhizoma ligustici chuanxiong, and the effect of promoting qi circulation and relieving pain is achieved in the prescription; the caulis spatholobi and the salvia miltiorrhiza assist the ligusticum chuanxiong hort and the cortex moutan radicis to enhance the effect of activating blood and dissolving stasis of the formula, the leech in the formula has a strong effect of activating blood and dissolving stasis, the effect of activating blood and dissolving stasis is optimal after the leech is matched with the ligusticum chuanxiong hort, the cortex moutan radicis, the caulis spatholobi and the salvia miltiorrhiza, the effect of activating qi and relieving pain can be improved when the rhizoma cyperi is matched with the ministerial medicine szechwan chinaberry fruit, the effect of enhancing the ministerial medicine is achieved, and the radix clematidis; cyathula root, radix Cyathulae has the actions of removing blood stasis, dredging the channels and joints, and guiding the medicine downward, and is used as a channel-guiding medicine, Licorice root, radix Glycyrrhizae can reduce the toxicity of various medicines, and harmonize the other medicines as harmonizing medicines, and the two medicines are used as guiding medicines. The medicines are combined to play the roles of activating blood circulation to dissipate blood stasis, promoting qi circulation and relieving pain.
The functions and indications of the invention are as follows: the Gao ancestral Jijimin plaster of the invention aims at the syndrome of qi stagnation and blood stasis type lumbar intervertebral disc protrusion, takes the treatment principles of promoting blood circulation by removing blood stasis and promoting qi circulation by relieving pain, adopts the formula principles of promoting blood circulation by removing blood stasis and promoting qi circulation by relieving pain, selects authentic medicinal materials, is reasonably compatible, and has extremely strong curative effect on qi stagnation and blood stasis type lumbar intervertebral disc protrusion.
The invention is an external plaster, can effectively reduce the toxic and side effects on the body compared with the traditional Chinese medicine dosage forms such as pills, decoction and the like which need to be taken orally, can be quickly absorbed by being applied to the affected part, directly reaches the focus, and has good market popularization value.
The treatment method can adopt one change of medicine for three days, five times are a treatment course, and the patient is required to pay attention to the cooperative treatment during the use period, rest as much as possible, no other physical treatments such as massage and the like are carried out, the medicine generally takes effect for five days for treating the lumbar intervertebral disc protrusion, and the lumbar intervertebral disc protrusion can be cured by two to three treatment courses. In particular, the medicine is also used for curing the diseases at one time.
Detailed Description
The present invention is further illustrated in detail by the following examples:
example 1: a plaster for treating lumbar intervertebral disc protrusion is prepared from the following medicines in parts by weight: the traditional Chinese medicine composition comprises, by weight, 90 parts of ligusticum chuanxiong hort, 45 parts of szechwan chinaberry fruit, 60 parts of moutan bark, 90 parts of suberect spatholobus stem, 60 parts of nutgrass galingale rhizome, 60 parts of clematis chinensis, 30 parts of turmeric root tuber, 90 parts of salvia miltiorrhiza, 15 parts of liquorice, 45 parts of medicinal cyathula root and 15 parts of leech.
Example 2: a plaster for treating lumbar intervertebral disc protrusion is prepared from the following medicines in parts by weight: 150 g of ligusticum chuanxiong hort, 90 g of szechwan chinaberry fruit, 120 g of tree peony bark, 150 g of suberect spatholobus stem, 90 g of nutgrass galingale rhizome, 90 g of clematis root, 90 g of turmeric root-tuber, 150 g of salvia miltiorrhiza, 90 g of liquorice, 90 g of medicinal cyathula root and 30g of leech.
Example 3: a plaster for treating lumbar intervertebral disc protrusion is prepared from the following medicines in parts by weight: 120 g of ligusticum chuanxiong hort, 60 g of szechwan chinaberry fruit, 90 g of tree peony bark, 120 g of suberect spatholobus stem, 75 g of nutgrass galingale rhizome, 75 g of clematis root, 60 g of turmeric root tuber, 120 g of salvia miltiorrhiza, 60 g of liquorice, 60 g of medicinal cyathula root and 21 g of leech.
The preparation method of the traditional Chinese medicine in the embodiment 1-3 comprises the following steps:
step 1: putting the medicines into a container, and then mixing the medicines with oil 1: 3, pouring the sesame oil and the medicines in the container together according to the weight ratio, and soaking the medicines for several days according to the principles of summer three, autumn five and winter ten for later use;
step 2: pouring the standby medicine and the oil into a copper pot, decocting for 1 hour by small fire (200 ℃), then frying the medicine by big fire (280-;
and step 3: weighing the weight of the medicinal oil, boiling in a pot, adding 240 g of Plumbum Preparatium into each kilogram of medicinal oil as a basic standard, boiling with slow fire, carefully observing, carefully testing with water, and immediately taking the pot out of the fire when the plaster is picked up by a wooden stick and dropped into water to form a mass and fall to the bottom, thus obtaining the plaster;
and 4, step 4: stopping heating for about 20 min, soaking in cold water for 5-7 days, changing water for several times, taking out, air drying, and storing;
and 5: according to the dosage at any time, the plaster blocks are put in a pot to be heated to soften, and then the plaster blocks can be processed into finished plasters with different types.
The present invention is not limited to the above-mentioned preferred embodiments, and any other products similar or identical to the present invention, which can be obtained by anyone based on the teaching of the present invention, fall within the protection scope of the present invention.
1. Clinical data
1.1 sources of cases
The study subjects are 48 patients who purchase Gao ancestral Jimin emplastrums in Baofeng county of the mountain Flat mountain city of Henan province from 3 months in 2019 to 1 month in 2020, the patients are divided into two types, one type is 24 patients who are treated directly from my place after the illness, the other type is 24 patients who are treated by other hospitals and are not treated for more than half a month after the medication is stopped.
1.2 diagnostic criteria
1.2.1 Western diagnostic standards
The diagnosis standard of the lumbar intervertebral disc protrusion is as follows:
1. there is a history of chronic injury to the waist.
2. Lumbago with sciatica.
3. Lumbar scoliosis deformity, disappearance of physiological lordosis, limited movement, tenderness beside the spinous process and irradiation to the lower limbs.
4. The straight leg elevation test and the reinforcement test are positive. The test of neck bending, the test of jugular vein compression and the test of femoral nerve traction are positive.
5. The nervous system examination shows abnormal reflection of the achilles tendon of knee, hyperesthesia or dullness of the nerve segment of the skin of the lower limb, and weakened dorsiflexion or plantarflexion of hallux toes.
The narrowing of the intervertebral space, the proliferation of the vertebral margin, the scoliosis, the disappearance of the lordosis and other diseases can be seen on the X-ray plain film. The spinal cord radiography can show the defect of pressure trace in front of the dura mater.
And 7, prompting the herniation of the intervertebral disc by CT scanning and MRI.
1.2.2 Chinese medicine diagnostic standards
Lumbar intervertebral disc prolapse due to qi stagnation and blood stasis: patients may generally have a significant history of trauma. The lumbar region is affected by the injury, the pain is hard to endure, and the spine is bent laterally. Obvious pressure pain points are arranged on one side of the sacrum 1 of the 4.5 or 5 waist, and the pressure pain points radiate to lower limbs, so that the cough is aggravated; pain and numbness of the lower limbs, even muscular atrophy, and positive straight leg raising test can be seen in the later stage. The tongue is purple-dark and the pulse is astringent, wiry and rapid. After injury, qi and blood stasis blocks the meridians and collaterals, and stagnation of qi and blood leads to pain.
1.3 case selection
1.3.1 case inclusion criteria
(1) The lumbar intervertebral disc protrusion meets the diagnosis standards of the traditional Chinese medicine and the western medicine, and has the syndrome type of qi stagnation and blood stasis;
(2) when the plaster is used, other medicines for treating the protrusion of the lumbar intervertebral disc are not used at the same time;
(3) the age is 30-75 years.
1.3.2 case exclusion criteria
(1) The researchers may be affected by other medicines for treating the protrusion of the lumbar intervertebral disc within half a month;
(2) pregnant, menstrual, and lactating women;
(3) patients with other types of prolapse of lumbar intervertebral disc.
2. Research method
2.1 treatment regimens
(1) Changing the dressing once in three days, and taking five times as a treatment course;
(2) the patients have more rest without physical treatment such as massage, traction and the like.
2.2 therapeutic efficacy assessment criteria
The effective cure rate of the traditional Chinese medicine is counted, and the curative effect standard is as follows:
and (3) curing: the symptoms completely disappear or nearly disappear, the straight leg elevation test can reach about 85 degrees, and the original work can be recovered.
Improvement: the symptoms are mostly disappeared, the straight leg elevation test exceeds 70 degrees, and the original work can be basically recovered.
The method has the following advantages: the symptom part disappears, and the straight leg is lifted and improved than before treatment, so that the patient can play a light role.
And (4) invalidation: the symptoms are not improved and the patient cannot participate in the work.
2.3 statistical results
42 patients who met the cure criteria, 5 patients who met the improvement criteria, 1 patient who met the effective criteria, and 0 patient who met the ineffective criteria for 48 patients.
2.4 typical cases:
in the middle school, the patient is 63 years old in the present year, the patient is 13781845829 with the telephone, the family member Shangxiangchun Gao, the patient suddenly suffers from lumbar disc herniation in 2019, the patient has difficulty walking when the patient is serious, the patient is plastered by the ancestors of Gao, the pain is obviously relieved for two days, the patient is completely cured in half a month, and the body is recovered to be normal.
Zhengspanish, female, 43 years old, telephone 13071718608, Dingshan tap water company, lumbar disc herniation in 2017, the disease can not be cured after going to hospital for many times, after using the Gao ancestral plaster, the disease condition turns to mild in 3 days, the pain disappears completely in half a month, and the body returns to normal.
Zhang Qing Miao, female, age 61, Phone 13271490065, Dong district Water company of Shanwei of Flat-topped mountain, get lumbar disc herniation and knee joint hyperostosis several years ago, can not be cured within several years, later used Gao ancestral Ji nationality emplastrum, felt slight illness in half a month, two months and completely cured.
Xu nationality, male, 61 years old, telephone 15737534354, business town Gao Xinzhuancun, 2016 type lumbar disc herniation, loose life, sometimes can not walk in the road, in hospital treatment is ineffective for many times, later used Gao ancestral Jijimin plaster, felt big and light in 3 days, and can dry in about 20 days.

Claims (3)

1. A plaster for treating lumbar intervertebral disc protrusion is characterized in that: the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 90-150 parts of ligusticum chuanxiong hort, 45-90 parts of szechwan chinaberry fruit, 60-120 parts of moutan bark, 90-150 parts of suberect spatholobus stem, 60-90 parts of nutgrass galingale rhizome, 60-90 parts of clematis root, 30-90 parts of turmeric root-tuber, 90-150 parts of salvia miltiorrhiza, 15-90 parts of liquorice, 45-90 parts of medicinal cyathula root and 15-30 parts of leech.
2. The plaster for treating lumbar intervertebral disc protrusion according to claim 1, wherein: the medicine is prepared from the following medicines in parts by weight: a plaster for treating lumbar intervertebral disc protrusion is prepared from the following medicines in parts by weight: 120 parts of ligusticum chuanxiong hort, 60 parts of szechwan chinaberry fruit, 90 parts of tree peony bark, 120 parts of suberect spatholobus stem, 75 parts of nutgrass galingale rhizome, 75 parts of clematis root, 60 parts of turmeric root-tuber, 120 parts of salvia miltiorrhiza, 60 parts of liquorice, 60 parts of medicinal cyathula root and 21 parts of leech.
3. A process for the preparation of a plaster for the treatment of lumbar intervertebral disc protrusion according to claim 1 or 2, which comprises the following steps:
step 1: putting the medicines into a container, and then mixing the medicines with oil 1: 3, pouring the sesame oil and the medicines in the container together according to the weight ratio, and soaking the medicines for several days according to the principles of summer three, autumn five and winter ten for later use;
step 2: pouring the standby medicine and the oil into a copper pot, decocting for 1 hour by small fire (200 ℃), then frying the medicine by big fire (280-;
and step 3: weighing the weight of the medicinal oil, boiling in a pot, adding 240 g of Plumbum Preparatium into each kilogram of medicinal oil as a basic standard, boiling with slow fire, carefully observing, carefully testing with water, and immediately taking the pot out of the fire when the plaster is picked up by a wooden stick and dropped into water to form a mass and fall to the bottom, thus obtaining the plaster;
and 4, step 4: stopping the plaster for about 20 minutes after the plaster leaves the fire, continuously spreading the plaster in cold water for removing fire toxin, soaking for 5-7 days, changing water for several times in the midway, taking out the plaster from the water, airing until no moisture exists, and finally collecting and storing;
and 5: according to the dosage at any time, the plaster blocks are put in a pot to be heated to soften, and then the plaster blocks can be processed into finished plasters with different types.
CN202010371107.2A 2020-05-06 2020-05-06 Plaster for treating lumbar intervertebral disc protrusion and preparation method thereof Pending CN111437361A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101912458A (en) * 2010-08-10 2010-12-15 王朋 Medicament for treating protrasion of the lumbar intervertebral disci
CN103961596A (en) * 2014-05-29 2014-08-06 张玉芳 Traditional Chinese medicine for treating prolapse of lumbar intervertebral disc
CN104940476A (en) * 2014-12-02 2015-09-30 杨丛刚 Externally applied wiping ointment for treating cervical vertebra and lumbar vertebra diseases and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101912458A (en) * 2010-08-10 2010-12-15 王朋 Medicament for treating protrasion of the lumbar intervertebral disci
CN103961596A (en) * 2014-05-29 2014-08-06 张玉芳 Traditional Chinese medicine for treating prolapse of lumbar intervertebral disc
CN104940476A (en) * 2014-12-02 2015-09-30 杨丛刚 Externally applied wiping ointment for treating cervical vertebra and lumbar vertebra diseases and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
彭利群: "腰椎间盘突出症的辨证施治", 《新中医》 *

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