CN104984069A - Traditional Chinese medicinal narcotic applied in painless abortion surgery, and preparation method thereof - Google Patents
Traditional Chinese medicinal narcotic applied in painless abortion surgery, and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicinal narcotic applied in painless abortion surgery, and a preparation method thereof. Raw medicinal materials of the traditional Chinese medicinal narcotic comprise Herb of Entire Meconopsis, Cladonia fallax Abbayes, Devilpepper Root, Liparis japonica, Lethariella zahlbruckneria, Ixeri sonhifolia, Marasmius androsaceus, Psychotria siamica (Craib) Hutch., Aconitum pseudostapfianum and panax notoginseng. The traditional Chinese medicinal narcotic applied in painless abortion surgery has the advantages of substantial pain easing effect and low adverse reaction rate.
Description
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to Chinese medicinal narcotic and the preparation method of a kind of painless abortion operation application.
Background technology
Artificial abortion, due to simple to operate, does not previously manyly use anesthesia, but without surgery under anesthesia, in art, the patient of more than 90% tells pain and occurs decreased heart rate, the blood pressure drops even multiple untoward reaction such as artificial abortion syndrome.Painless abortion operation at present more adopts Western medicine anesthesia injection method, but some patient compares again the untoward reaction fearing Western medicine anaesthetic, as complete in analgesia, cardiovascular suppresses, injection site pain and postoperative recovery slow etc., patient is caused easily to occur as pale complexion, nervous, uncomfortable in chest, nauseating etc., shock can also be there is in serious, and the postoperative anaphylaxis in addition etc. had, bring many miseries to patient.
Summary of the invention
Technical problem to be solved by this invention is, the Chinese medicinal narcotic providing a kind of painless abortion to perform the operation application and preparation method, and Chinese medicine of the present invention analgesic effect when painless abortion operation application is remarkable, and untoward reaction rate is low.
In order to solve the problems of the technologies described above, the invention provides the Chinese medicinal narcotic of a kind of painless abortion operation application, its raw medicinal material comprises: Herba meconopsis integrifoliae, Cladonia fallax Abbayes, Radix Rauvolfiae, Liparis japonica (Miq.) Maxim., Alectoria virens Tayl., Herba Ixeritis Sonchifoliae, Marasmius equicrinis Muell., floral leaf Psychotria rubra (Lour.) Poir. wood, stifled loudspeaker and Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae).
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba meconopsis integrifoliae 10 ~ 20 parts, Cladonia fallax Abbayes 40 ~ 50 parts, Radix Rauvolfiae 10 ~ 20 parts of parts, Liparis japonica (Miq.) Maxim. 30 ~ 40 parts, Alectoria virens Tayl. 30 ~ 40 parts, Herba Ixeritis Sonchifoliae 20 ~ 30 parts, Marasmius equicrinis Muell. 40 ~ 50 parts, 20 ~ 30 parts, floral leaf Psychotria rubra (Lour.) Poir. wood, stifled loudspeaker 15 ~ 25 parts and Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 25 ~ 35 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba meconopsis integrifoliae 10 ~ 15 parts, Cladonia fallax Abbayes 40 ~ 45 parts, Radix Rauvolfiae 10 ~ 15 parts of parts, Liparis japonica (Miq.) Maxim. 30 ~ 35 parts, Alectoria virens Tayl. 30 ~ 35 parts, Herba Ixeritis Sonchifoliae 20 ~ 25 parts, Marasmius equicrinis Muell. 40 ~ 45 parts, 20 ~ 25 parts, floral leaf Psychotria rubra (Lour.) Poir. wood, stifled loudspeaker 15 ~ 20 parts and Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 30 ~ 35 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba meconopsis integrifoliae 11 parts, Cladonia fallax Abbayes 44 parts, Radix Rauvolfiae 13 parts, Liparis japonica (Miq.) Maxim. 33 parts, Alectoria virens Tayl. 32 parts, Herba Ixeritis Sonchifoliae 21 parts, 24 parts, Marasmius equicrinis Muell. 42 parts, floral leaf Psychotria rubra (Lour.) Poir. wood, stifled loudspeaker 17 parts and Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 34 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba meconopsis integrifoliae 14 parts, Cladonia fallax Abbayes 45 parts, Radix Rauvolfiae 15 parts, Liparis japonica (Miq.) Maxim. 35 parts, Alectoria virens Tayl. 34 parts, Herba Ixeritis Sonchifoliae 25 parts, 23 parts, Marasmius equicrinis Muell. 44 parts, floral leaf Psychotria rubra (Lour.) Poir. wood, stifled loudspeaker 20 parts and Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 32 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba meconopsis integrifoliae 12 parts, Cladonia fallax Abbayes 41 parts, Radix Rauvolfiae 12 parts, Liparis japonica (Miq.) Maxim. 31 parts, Alectoria virens Tayl. 30 parts, Herba Ixeritis Sonchifoliae 23 parts, 21 parts, Marasmius equicrinis Muell. 43 parts, floral leaf Psychotria rubra (Lour.) Poir. wood, stifled loudspeaker 16 parts and Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 35 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is injectable powder, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 3 DEG C ~ 6 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is decoction, and its preparation method comprises the following steps:
The first step: purple casserole is put in described raw medicinal material mixing, adds clear water, to the dipped medical material upper surface of clear water 4 ~ 6cm, soak 2 ~ 4 hours;
Second step: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct 1 ~ 2 little dosage up to medicinal liquid be slowly 100 ~ 200ml, filters, obtain filtrate a, for subsequent use;
3rd step: residue medicinal residues are added clear water again, to the dipped medical material upper surface of clear water 3 ~ 5cm, soaks 1 ~ 3 hour;
4th step: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct 45 ~ 60 minutes dosage to medicinal liquid be slowly 100 ~ 200ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is liniment, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 30 ~ 50 hours under the condition of 3 DEG C ~ 6 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 60 ~ 90 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, adds the deionized water relative to mixed powder quality 2 ~ 3 times, decocts 2 ~ 4 hours, filter, obtain medicine juice in the mixed powder that second step obtains.
Beneficial effect of the present invention: Chinese medicine of the present invention is when the clinical practice that painless abortion is performed the operation, and both can be anaesthetized sb. generally by for oral administration or injection, also can carry out local anesthesia by injecting or smearing, analgesic effect is remarkable, and untoward reaction rate is low.
Detailed description of the invention
The invention provides the Chinese medicinal narcotic of a kind of painless abortion operation application, its raw medicinal material comprises: Herba meconopsis integrifoliae, Cladonia fallax Abbayes, Radix Rauvolfiae, Liparis japonica (Miq.) Maxim., Alectoria virens Tayl., Herba Ixeritis Sonchifoliae, Marasmius equicrinis Muell., floral leaf Psychotria rubra (Lour.) Poir. wood, stifled loudspeaker and Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae).
In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:
Herba meconopsis integrifoliae: the flower that [source] is the full edge Herba meconopsis integrifoliae of bloodroot, fruit or herb.[nature and flavor] are bitter, puckery, are slightly cold.[return through] returns liver, kidney, large intestine channel.[function cures mainly] clearing away heat-damp and promoting diuresis, antitussive and antiasthmatic.Control pneumonia cough, hepatitis, biliary colic, gastroenteritis, damp and hot edema, leucorrhea, dysmenorrhea.
Cladonia fallax Abbayes: [source] is the entirety of Cladoniaceae plant tophus stamen.[nature and flavor] bitter in the mouth, property is put down.[function cures mainly] is calm, antiinflammatory, pain relieving.Control epilepsy, psychotic disorder, neurasthenia, the vertigo.
Radix Rauvolfiae: [source] is the root of apocynaceae plant Radix Rauvolfiae.[nature and flavor] are bitter, cold.Liver-fire, falls in [function cures mainly] fresh breeze heat, detumescence poison.Main cold, fever, laryngopharynx swelling and pain, hypertension, has a headache dizzy, acute filthy disease, and stomachache is vomited and diarrhoea, pruritus due to wind pathogen skin ulcer scabies.
Liparis japonica (Miq.) Maxim.: [source] is the whole herb with root of orchid Liparis japonica (Miq.) Maxim..[nature and flavor] are puckery, flat.[function cures mainly] promoting blood flow to regulate menstruation, hemostasis, pain relieving, heart tonifying, calm.Control metrorrhagia, leucorrhea, puerperal abdonimal pain, wound first aid.
Alectoria virens Tayl.: the filamentous that [source] is sent out for Usneaceae plant greenery.[nature and flavor] are sweet, bitter, flat.[function cures mainly] except rheumatism, hemostasis and pain-relieving, regulating menstruation and activating blood, tranquillizing and allaying excitement, strengthening the spleen and stomach.Control impairment caused by overstrain lumbago and skelalgia, traumatic hemorrhage, menoxenia, uterine prolapse, leucorrhea, psychosis, epilepsy, hemiplegia, sexual impotence, have a dizzy spell.
Herba Ixeritis Sonchifoliae: [source] is the herb of feverfew Herba Ixeritis Sonchifoliae.[nature and flavor] bitter in the mouth, pungent, cold in nature.[function cures mainly] alleviating pain and detumescence, heat-clearing and toxic substances removing.Main headache, toothache, stomachache, postoperative pain, traumatic pain, appendicitis, enteritis, pulmonary abscess, laryngopharynx swelling and pain, carbuncle furuncle.
Marasmius equicrinis Muell.: [source] is Bai Mo section fungus Marasmius androsaceus (L.ex Fr.) Fr. rhzomorph.[nature and flavor] micro-hardship, warm in nature.[return through] returns Liver Channel.[function cures mainly] invigorates blood circulation analgesic therapy.Main traumatic injury, fracture pain, migraine, various neuralgia, lumbago and skelalgia, rheumatic arthralgia.
Floral leaf Psychotria rubra (Lour.) Poir. wood: [source] is the Herb of Maguireothamnus speciosus floral leaf Psychotria rubra (Lour.) Poir. wood.[nature and flavor] are bitter, cool.[function cures mainly] heat-clearing and toxic substances removing, expelling wind and removing dampness, calm, analgesia.Main bacterium dysentery, enteritis, diarrhoea, cough, epilepsy, nephritis, cystitis, rheumatic lumbago and scelalgia.
Stifled loudspeaker: [another name] Bleeding-Stopping Bolus, Radix Arnebiae (Radix Lithospermi) crow, Guizhou Province principal solution, Radix Aconiti Kusnezoffii, rattan crow.[source] medical material Ji Yuan: be the tuber of ranunculaceae plant purple monkshood root.Gather and store: digging over year in autumn, removing residual prestige and earth, drying or dry.[nature and flavor] acrid in the mouth; Hot in nature; Poisonous.[function cures mainly] wind-damp dispelling; Removing toxic substances; Relieving alcoholic intoxication.Main rheumatic ostalgia; Traumatic pain.
Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae): [source] Guangzhou army " conventional Chinese herbal medicine handbook ".[another name] Radix Cissi Kerrii (" conventional Chinese herbal medicine color atlas "), stone qin potato, Stephania cepharatha Hayata (" Guangxi Chinese herbal medicine "), DIWUGUI (Nanchuan " conventional Chinese herbal medicine handbook "), Radix Stephaniae Epigaeae (" mountain of papers Chinese herbal medicine ").[source] is the tuber of menispermaceous plants Radix Stephaniae Japonicae.The whole year can adopt.Clean, section, dries.[nature and flavor] Guangzhou army " conventional Chinese herbal medicine handbook ": " bitter, cold."。[function cures mainly] heat-clearing and toxic substances removing, benefiting stomach and stopping pain, dissipating blood stasis for subsidence of swelling.Control exogenous cough, pharyngalgia, aphtha of the mouth and tongue, vomiting and diarrhoea, dysentery, stomachache, swollen ulcer drug, traumatic injury.Each discussion: 1. Guangzhou army " conventional Chinese herbal medicine handbook ": " heat-clearing and toxic substances removing, eliminating stasis to stop pain.Control stomach and duodenum to burst hemorrhoid pain, treating swelling and pain by traumatic injury, neuralgia, toothache, acute gastroenteritis, bacillary dysentery, upper respiratory tract infection, pharyngalgia." 2. " conventional Chinese herbal medicine color atlas ": " benefiting stomach and stopping pain, subduing swelling and detoxicating."。3. Guangzhou air force " conventional Chinese herbal medicine handbook ": " control pulmonary tuberculosis, carbuncle skin ulcer, abscess, dyspepsia, stomatitis."。4. " mountain of papers Chinese herbal medicine ": " treat for stomachache, abdominal distention, diarrhoea, malaria."。5. Nanchuan " conventional Chinese herbal medicine handbook ": " control boil on the nape opposite the mouth and burn."。[extracts] " Chinese medicine voluminous dictionary "
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba meconopsis integrifoliae 10 ~ 20 parts, Cladonia fallax Abbayes 40 ~ 50 parts, Radix Rauvolfiae 10 ~ 20 parts of parts, Liparis japonica (Miq.) Maxim. 30 ~ 40 parts, Alectoria virens Tayl. 30 ~ 40 parts, Herba Ixeritis Sonchifoliae 20 ~ 30 parts, Marasmius equicrinis Muell. 40 ~ 50 parts, 20 ~ 30 parts, floral leaf Psychotria rubra (Lour.) Poir. wood, stifled loudspeaker 15 ~ 25 parts and Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 25 ~ 35 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba meconopsis integrifoliae 10 ~ 15 parts, Cladonia fallax Abbayes 40 ~ 45 parts, Radix Rauvolfiae 10 ~ 15 parts of parts, Liparis japonica (Miq.) Maxim. 30 ~ 35 parts, Alectoria virens Tayl. 30 ~ 35 parts, Herba Ixeritis Sonchifoliae 20 ~ 25 parts, Marasmius equicrinis Muell. 40 ~ 45 parts, 20 ~ 25 parts, floral leaf Psychotria rubra (Lour.) Poir. wood, stifled loudspeaker 15 ~ 20 parts and Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 30 ~ 35 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba meconopsis integrifoliae 11 parts, Cladonia fallax Abbayes 44 parts, Radix Rauvolfiae 13 parts, Liparis japonica (Miq.) Maxim. 33 parts, Alectoria virens Tayl. 32 parts, Herba Ixeritis Sonchifoliae 21 parts, 24 parts, Marasmius equicrinis Muell. 42 parts, floral leaf Psychotria rubra (Lour.) Poir. wood, stifled loudspeaker 17 parts and Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 34 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba meconopsis integrifoliae 14 parts, Cladonia fallax Abbayes 45 parts, Radix Rauvolfiae 15 parts, Liparis japonica (Miq.) Maxim. 35 parts, Alectoria virens Tayl. 34 parts, Herba Ixeritis Sonchifoliae 25 parts, 23 parts, Marasmius equicrinis Muell. 44 parts, floral leaf Psychotria rubra (Lour.) Poir. wood, stifled loudspeaker 20 parts and Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 32 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba meconopsis integrifoliae 12 parts, Cladonia fallax Abbayes 41 parts, Radix Rauvolfiae 12 parts, Liparis japonica (Miq.) Maxim. 31 parts, Alectoria virens Tayl. 30 parts, Herba Ixeritis Sonchifoliae 23 parts, 21 parts, Marasmius equicrinis Muell. 43 parts, floral leaf Psychotria rubra (Lour.) Poir. wood, stifled loudspeaker 16 parts and Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 35 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is injectable powder, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 3 DEG C ~ 6 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is decoction, and its preparation method comprises the following steps:
The first step: purple casserole is put in described raw medicinal material mixing, adds clear water, to the dipped medical material upper surface of clear water 4 ~ 6cm, soak 2 ~ 4 hours;
Second step: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct 1 ~ 2 little dosage up to medicinal liquid be slowly 100 ~ 200ml, filters, obtain filtrate a, for subsequent use;
3rd step: residue medicinal residues are added clear water again, to the dipped medical material upper surface of clear water 3 ~ 5cm, soaks 1 ~ 3 hour;
4th step: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct 45 ~ 60 minutes dosage to medicinal liquid be slowly 100 ~ 200ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is liniment, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 30 ~ 50 hours under the condition of 3 DEG C ~ 6 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 60 ~ 90 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, adds the deionized water relative to mixed powder quality 2 ~ 3 times, decocts 2 ~ 4 hours, filter, obtain medicine juice in the mixed powder that second step obtains.
Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.
Embodiment 1: injectable powder
Get Herba meconopsis integrifoliae 110g, Cladonia fallax Abbayes 440g, Radix Rauvolfiae 130g, Liparis japonica (Miq.) Maxim. 330g, Alectoria virens Tayl. 320g, Herba Ixeritis Sonchifoliae 210g, Marasmius equicrinis Muell. 420g, floral leaf Psychotria rubra (Lour.) Poir. wood 240g, stifled loudspeaker 170g and Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 340g;
Its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 5 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 4 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 32 hours under the condition of 5 DEG C, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 50 minutes at this, the micron particles of acquisition 1 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets the mixed powder 16g that second step obtains, adds propylene glycol 35g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1.3g needle-use activated carbon, fully stirs 40 minutes; Decarbonization filtering; With 0.22 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
Embodiment 2: decoction
Get Herba meconopsis integrifoliae 140g, Cladonia fallax Abbayes 450g, Radix Rauvolfiae 150g, Liparis japonica (Miq.) Maxim. 350g, Alectoria virens Tayl. 340g, Herba Ixeritis Sonchifoliae 250g, Marasmius equicrinis Muell. 440g, floral leaf Psychotria rubra (Lour.) Poir. wood 230g, stifled loudspeaker 200g and Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 320g;
Prepare according to the following steps:
The first step: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 4cm, soak 4 hours;
Second step: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 1 little dosage up to medicinal liquid be slowly 150ml, filters, obtain filtrate a, for subsequent use;
3rd step: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 3cm, soaks 1 hour;
4th step: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 50 minutes dosage to medicinal liquid be slowly 150ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.
Embodiment 3: liniment
Get Herba meconopsis integrifoliae 120g, Cladonia fallax Abbayes 410g, Radix Rauvolfiae 120g, Liparis japonica (Miq.) Maxim. 310g, Alectoria virens Tayl. 300g, Herba Ixeritis Sonchifoliae 230g, Marasmius equicrinis Muell. 430g, floral leaf Psychotria rubra (Lour.) Poir. wood 210g, stifled loudspeaker 160g and Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 350g;
Its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 5 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 45 hours under the condition of 3 DEG C, adopt percolation with the speed of 1ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 80 minutes at this, the micron particles of acquisition 0.5 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, adds the deionized water relative to mixed powder quality 2.5 times, decocts 3 hours, filter, obtain medicine juice in the mixed powder that second step obtains.
Toxicity test:
Acute toxicity testing: application mice 60, male and female half and half, body weight 22 ~ 30g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine decoction prepared by embodiments of the invention 2, (concentration is 7.30g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 36.5 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage decoction LD50>36.5 crude drug/kg of the present invention, every day, maximum dosage-feeding was 73.0 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 6.4g crude drug/day/people, adult body weight in 60KG, average dosage is 0.107g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 26g) oral administration gavage Chinese medicine of the present invention is 682 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine embodiment 2 decoction of the present invention presses 13.12,19.03 and 37.45g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection: whole 84 routine cases be in August, 2012 ~ carry out the anemia of pregnant woman of my institute's termination of pregnancy in June, 2014 voluntarily, patient is divided into experimental group and matched group at random, wherein experimental group 42 people, 21 ~ 33 years old age, mean age (23.5 ± 2.7) year, average pregnancy cycle (7.2 ± 1.6) week; Matched group 42 people, 20 ~ 34 years old age, the mean age (23.1 ± 2.4) year, average pregnancy cycle (7.4 ± 1.3) week.Two groups of ages, the equal not statistically significant of pregnancy cycle comparing difference (p>0.05).All anemia of pregnant woman are healthy pregnant women, perfect without cardio-pulmonary function medical history, kidney medical history, liver function, without anesthesia contraindication, turn out to be in utero pregnant through Visual quality inspection.
Experimental technique: two groups of anemia of pregnant woman fasting 4 ~ 6 hours in the preoperative, sets up venous access before anesthesia, detects maternal heart rate, blood pressure, keep anemia of pregnant woman's smooth breathing.
Matched group: first with 10ml normal saline, the fentanyl of 3mg/kg is diluted to intravenous injection liquid, 30s injects complete, to have pushed away after 2min intravenous injection 2mg/kg propofol again, observed anemia of pregnant woman's reaction, caused that anemia of pregnant woman occurs that expression in the eyes stagnates, loss of eyelash reflex time can start operation.Speed of injecting is according to anemia of pregnant woman's clinical response, and to maintain anemia of pregnant woman without groan, and limbs are advisable without activity, causes operation complete.The rear operation analgesic effect to two groups of having performed the operation carries out statistical.
Experimental group: the oral embodiment of the present invention 1 decoction, observe anemia of pregnant woman reaction, cause anemia of pregnant woman occur expression in the eyes stagnate, loss of eyelash reflex time can start operation.
Monitoring index: monitor in preoperative, art and postoperative 10min maternal heart rate, blood pressure, blood oxygen saturation and breath state, observe anesthesia duration and postoperative untoward reaction, prepares crash equipment with for subsequent use in operating room, the monitoring of anaesthetist's whole process.
Evaluation criterion: operation analgesic effect is divided into 3 grades: effective: completely painless in anemia of pregnant woman's art, after question closely memoryless, coordinate completely.Effective: small size limb activity in anemia of pregnant woman's art, expression is slightly painful, but can keep coordinating.Invalid: significantly limb activity in anemia of pregnant woman's art, painful groan, cannot coordinate operation, must add anaesthesia dosage or change anaesthetic.
Result: operation analgesic effect compares, in table 1.Anesthesia duration compares with untoward reaction, in table 2.
Table 1: two groups of corrective surgery analgesic effects compare
| Group | n | Effective | Effectively | Invalid | Effectively total |
| Experimental group | 42 | 35(83.33％) | 7(16.67％) | 0 | 42(100％) |
| Matched group | 42 | 28(66.67％) | 14(33.33％) | 0 | 42(100％) |
Table 1 shows, and experimental group analgesic effect is better than matched group, can significantly improve obvious effective rate.
Table 2: two groups of patient's anesthesia durations compare with untoward reaction
| Group | n | Anesthesia duration/min | Untoward reaction number of cases (%) |
| Experimental group | 42 | 11.36±3.27 | 5(11.90％) |
| Matched group | 42 | 9.24±2.15 | 24(57.14％) |
Table 2 shows, and matched group anesthesia duration is better than experimental group, but difference is little.But the untoward reaction of experimental group is starkly lower than matched group.Experimental group only has 5 routine patients that postoperative blurring of vision, the untoward reaction such as dizzy or tired occur, and do not do any process, after postoperative 4 ~ 6h, symptom is died away; But and there is the untoward reaction such as postoperative spasm, postoperative vomiting in the routine patient of matched group 24, need give with patient's spasmolytic, anti-emetic thing after symptom can disappear, two groups of comparing differences have statistical significance (P<0.05).
Anesthesia Monitoring result: matched group Most patients heart rate, blood pressure in operation process decline to some extent, but all in safety range, wherein 3 routine anemia of pregnant woman also occur that respiratory arrest continues 10 ~ 15 seconds after being anesthetized, but recover all voluntarily.And tachycardic situation appears in the routine anemia of pregnant woman of experimental group 4, have no other significant changes.
In addition, according to clinical practice, the injectable powder of the embodiment of the present invention 1 can as local anesthesia or general anesthesia medicine (when local anaesthesia and general anesthesia, dosage is different), the liniment of the embodiment of the present invention 3 can local anesthetic the most, be applied to Firmiana platanifolia (Linn. f.) Marsili abortion, the technique effect similar with above-mentioned experiment can also be obtained.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (10)
1. a Chinese medicinal narcotic for painless abortion operation application, it is characterized in that, each raw medicinal material of described Chinese medicine comprises: Herba meconopsis integrifoliae, Cladonia fallax Abbayes, Radix Rauvolfiae, Liparis japonica (Miq.) Maxim., Alectoria virens Tayl., Herba Ixeritis Sonchifoliae, Marasmius equicrinis Muell., floral leaf Psychotria rubra (Lour.) Poir. wood, stifled loudspeaker and Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae).
2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba meconopsis integrifoliae 10 ~ 20 parts, Cladonia fallax Abbayes 40 ~ 50 parts, Radix Rauvolfiae 10 ~ 20 parts of parts, Liparis japonica (Miq.) Maxim. 30 ~ 40 parts, Alectoria virens Tayl. 30 ~ 40 parts, Herba Ixeritis Sonchifoliae 20 ~ 30 parts, Marasmius equicrinis Muell. 40 ~ 50 parts, 20 ~ 30 parts, floral leaf Psychotria rubra (Lour.) Poir. wood, stifled loudspeaker 15 ~ 25 parts and Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 25 ~ 35 parts.
3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba meconopsis integrifoliae 10 ~ 15 parts, Cladonia fallax Abbayes 40 ~ 45 parts, Radix Rauvolfiae 10 ~ 15 parts of parts, Liparis japonica (Miq.) Maxim. 30 ~ 35 parts, Alectoria virens Tayl. 30 ~ 35 parts, Herba Ixeritis Sonchifoliae 20 ~ 25 parts, Marasmius equicrinis Muell. 40 ~ 45 parts, 20 ~ 25 parts, floral leaf Psychotria rubra (Lour.) Poir. wood, stifled loudspeaker 15 ~ 20 parts and Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 30 ~ 35 parts.
4. the Chinese medicine as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba meconopsis integrifoliae 11 parts, Cladonia fallax Abbayes 44 parts, Radix Rauvolfiae 13 parts, Liparis japonica (Miq.) Maxim. 33 parts, Alectoria virens Tayl. 32 parts, Herba Ixeritis Sonchifoliae 21 parts, 24 parts, Marasmius equicrinis Muell. 42 parts, floral leaf Psychotria rubra (Lour.) Poir. wood, stifled loudspeaker 17 parts and Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 34 parts.
5. the Chinese medicine as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is injectable powder, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 3 DEG C ~ 6 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
6. the Chinese medicine as described in Claims 1-4, is characterized in that, when the dosage form of described Chinese medicine is decoction, its preparation method comprises the following steps:
The first step: purple casserole is put in described raw medicinal material mixing, adds clear water, to the dipped medical material upper surface of clear water 4 ~ 6cm, soak 2 ~ 4 hours;
Second step: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct 1 ~ 2 little dosage up to medicinal liquid be slowly 100 ~ 200ml, filters, obtain filtrate a, for subsequent use;
3rd step: residue medicinal residues are added clear water again, to the dipped medical material upper surface of clear water 3 ~ 5cm, soaks 1 ~ 3 hour;
4th step: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct 60 ~ 90 minutes dosage to medicinal liquid be slowly 100 ~ 200ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.
7. the Chinese medicine as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is liniment, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 30 ~ 50 hours under the condition of 3 DEG C ~ 6 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 60 ~ 90 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, adds the deionized water relative to mixed powder quality 2 ~ 3 times, decocts 2 ~ 4 hours, filter, obtain medicine juice in the mixed powder that second step obtains.
8. a preparation method for Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is injectable powder, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 3 DEG C ~ 6 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
9. a preparation method for Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is decoction, and its preparation method comprises the following steps:
The first step: purple casserole is put in described raw medicinal material mixing, adds clear water, to the dipped medical material upper surface of clear water 4 ~ 6cm, soak 2 ~ 4 hours;
Second step: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct 1 ~ 2 little dosage up to medicinal liquid be slowly 100 ~ 200ml, filters, obtain filtrate a, for subsequent use;
3rd step: residue medicinal residues are added clear water again, to the dipped medical material upper surface of clear water 3 ~ 5cm, soaks 1 ~ 3 hour;
4th step: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct 60 ~ 90 minutes dosage to medicinal liquid be slowly 100 ~ 200ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.
10. a preparation method for Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is liniment, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 30 ~ 50 hours under the condition of 3 DEG C ~ 6 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 60 ~ 90 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, adds the deionized water relative to mixed powder quality 2 ~ 3 times, decocts 2 ~ 4 hours, filter, obtain medicine juice in the mixed powder that second step obtains.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1325719A (en) * | 2001-06-01 | 2001-12-12 | 张利斌 | Antalgesic liquid for cervical dilatation |
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| CN1325719A (en) * | 2001-06-01 | 2001-12-12 | 张利斌 | Antalgesic liquid for cervical dilatation |
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| CN105395791A (en) * | 2015-12-25 | 2016-03-16 | 青岛市第三人民医院 | Traditional Chinese medicine for painless induced abortion surgery anesthesia and preparation method thereof |
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