CN105395791A - Traditional Chinese medicine for painless induced abortion surgery anesthesia and preparation method thereof - Google Patents
Traditional Chinese medicine for painless induced abortion surgery anesthesia and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine for painless induced abortion surgery anesthesia and a preparation method thereof. The traditional Chinese medicine is prepared from salsola collina, ginseng rhizome, star-flower lysimachia, telegraph plants, cypress fruits, picea wood, all-grass of pilose toadlily, pellionia repens, choerospondias axillaries and lepironia articulata. The traditional Chinese medicine is used in cooperation with traditional anesthetics for painless induced abortion surgery, the analgesic effect of the traditional anesthetics can be enhanced, the anesthesia time is shortened, and adverse reaction rate of the traditional anesthetics is lowered.
Description
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to a kind of Chinese medicine and preparation method of painless induced abortion.
Background technology
Artificial abortion, due to simple to operate, does not previously manyly use anesthesia, but without surgery under anesthesia, in art, the patient of more than 90% tells pain and occurs decreased heart rate, the blood pressure drops even multiple untoward reaction such as artificial abortion syndrome.Painless abortion operation at present more adopts Western medicine anesthesia injection method, but some patient compares again the untoward reaction fearing Western medicine anaesthetic, as complete in analgesia, cardiovascular suppresses, injection site pain and postoperative recovery slow etc., patient is caused easily to occur as pale complexion, nervous, uncomfortable in chest, nauseating etc., shock can also be there is in serious, and the postoperative anaphylaxis in addition etc. had, bring many miseries to patient.
Summary of the invention
Technical problem to be solved by this invention is, a kind of Chinese medicine and preparation method of painless induced abortion are provided, Chinese medicine of the present invention is when painless abortion is performed the operation, traditional anaesthetic is coordinated to use, the analgesic effect of traditional anaesthetic can be strengthened, shorten anesthesia duration, reduce the untoward reaction rate of traditional anaesthetic.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine of painless induced abortion, its raw medicinal material comprises: Herba Salsolae Collinae, Rhizoma Ginseng, Lysimachia trientaloides Hemsl., telegraph plant, Strobilus Cupressi ， Wilsonii wood, Herba Tricyrtis Pilosae, Herba Pellioniae repentis, Fructus Choerospondiatis and Medulla Junci.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba Salsolae Collinae 10 ~ 20 parts, Rhizoma Ginseng 20 ~ 30 parts, Lysimachia trientaloides Hemsl. 10 ~ 20 parts, telegraph plant 10 ~ 20 parts, 10 ~ 20 parts, Strobilus Cupressi 20 ~ 30 Fen ， Wilsonii wood, Herba Tricyrtis Pilosae 10 ~ 20 parts, Herba Pellioniae repentis 20 ~ 30 parts, Fructus Choerospondiatis 10 ~ 20 parts and Medulla Junci 15 ~ 25 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba Salsolae Collinae 13 ~ 18 parts, Rhizoma Ginseng 20 ~ 25 parts, Lysimachia trientaloides Hemsl. 10 ~ 15 parts, telegraph plant 12 ~ 17 parts, 15 ~ 20 parts, Strobilus Cupressi 25 ~ 30 Fen ， Wilsonii wood, Herba Tricyrtis Pilosae 13 ~ 18 parts, Herba Pellioniae repentis 20 ~ 25 parts, Fructus Choerospondiatis 10 ~ 15 parts and Medulla Junci 18 ~ 23 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Salsolae Collinae 16 parts, Rhizoma Ginseng 22 parts, Lysimachia trientaloides Hemsl. 14 parts, telegraph plant 12 parts, 16 parts, Strobilus Cupressi 28 Fen ， Wilsonii wood, Herba Tricyrtis Pilosae 18 parts, Herba Pellioniae repentis 22 parts, Fructus Choerospondiatis 14 parts and Medulla Junci 20 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Salsolae Collinae 14 parts, Rhizoma Ginseng 25 parts, Lysimachia trientaloides Hemsl. 12 parts, telegraph plant 16 parts, 18 parts, Strobilus Cupressi 25 Fen ， Wilsonii wood, Herba Tricyrtis Pilosae 15 parts, Herba Pellioniae repentis 25 parts, Fructus Choerospondiatis 10 parts and Medulla Junci 22 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:
The first step, by Herba Salsolae Collinae, Rhizoma Ginseng, Lysimachia trientaloides Hemsl., telegraph plant, Fructus Choerospondiatis and Medulla Junci mixing, add relative to mixture 4 ~ 8 times amount determining alcohol be 75% ~ 85% alcohol reflux 2 ~ 4 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;
3rd step, the mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, carries out mixing by described dried cream powder and starch and processes, obtain mastic mixture; Described mastic and the weight ratio of starch are 1: 0.02 ~ 0.03; Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained;
5th step, described mastic compound particles and Pulvis Talci, magnesium stearate are carried out successively mixing processes, tabletting process, Cotton seeds, obtain Chinese medicine preparation tablet finished product; The weight ratio of described granule, Pulvis Talci, magnesium stearate is 100: 1 ~ 3: 0.15 ~ 0.3.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is glucose injection, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
Beneficial effect of the present invention: Chinese medicine of the present invention, when painless abortion is performed the operation, uses in conjunction with traditional anaesthetic, can strengthen the analgesic effect of traditional anaesthetic, shortens anesthesia duration, reduces the untoward reaction rate of traditional anaesthetic.
Detailed description of the invention
The invention provides a kind of Chinese medicine of painless induced abortion, its raw medicinal material comprises: Herba Salsolae Collinae, Rhizoma Ginseng, Lysimachia trientaloides Hemsl., telegraph plant, Strobilus Cupressi ， Wilsonii wood, Herba Tricyrtis Pilosae, Herba Pellioniae repentis, Fructus Choerospondiatis and Medulla Junci.
In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:
Herba Salsolae Collinae: [another name] prick fluffy, it is fluffy to sting, bright of trident, Pilus Sus domestica tassel, pitch bright, monkey hair, Herba galii veri, first fluffy stalk.[source] medical material Ji Yuan: be the herb of chenopod Herba Salsolae Collinae.[nature and flavor] are light; Cool in nature.[return through] Liver Channel.[function cures mainly] suppressing the hyperactive liver and subsiding YANG; Loosening bowel to relieve constipation.Main hypertension; How sick; Dizzy; Insomnia; Dryness of the intestine constipation.[extracts] " China's book on Chinese herbal medicine "
Rhizoma Ginseng: [another name] ginseng reed, Rhizoma Panacis Japonici.[source] medical material Ji Yuan: want stem for Araliaceae Radix Ginseng.[nature and flavor] sweet in the mouth; Micro-hardship; Warm in nature.[return through] returns stomach; Spleen; Lung meridian.[function cures mainly] ascending up spleen-Qi and Yang.Main sinking of QI due to deficiency of the spleen; Chronic diarrhea; Proctoptosis.[extracts] " China's book on Chinese herbal medicine "
Lysimachia trientaloides Hemsl.: [another name] infantile convulsion umbrella, Rhizoma Arisaematis, public Cortex torricelliae tiliifoliae, broken sunshade, back flower grass, lamp-stand list.[source] medical material Ji Yuan: be herb or the root of the narrow leaf Herba lysimachiae Paridiformis of Ofthe Primulaceae.[nature and flavor] are pungent; Warm in nature.[function cures mainly] dispelling wind and removing obstruction in the collateral; Promoting blood circulation and stopping pain.Main air pain of dampness syndrome; Hemiplegia; Infantile convulsion; Traumatic injury; Fracture.[extracts] " China's book on Chinese herbal medicine "
Telegraph plant: [another name] red hair hen grass, sing and close grass, distinguished and admirable grass, automatically careless.[source] pulse family telegraph plant, with all herbal medicine.[habitats distribution] Fujian, Taiwan, Guangxi and southwest.[nature and flavor] are micro-puckery, flat.[function cures mainly] calms the nerves, calm, promoting tissue regeneration by removing blood stasis, promoting blood circulation and detumescence.[extracts] " national Chinese herbal medicine compilation "
Strobilus Cupressi: [another name] Cupressaceae, Cedar tree.[source] medical material Ji Yuan: be the fruit of Cupressaceae plant Cupressus funebris Endl..[nature and flavor] are bitter; Sweet; Property is put down.[return through] heart; Lung meridian.[function cures mainly] dispels the wind; With in; Calm the nerves; Hemostasis.Main cold, fever; Gastralgic vomitting; Irritated; Insomnia; Over-strained hemoptysis.[extracts] " China's book on Chinese herbal medicine "
Wilsonii wood: [another name] Wilsonii, Hong Wilsonii.[source] medical material Ji Yuan: be branch tuberosity and the needle of pinaceae plant Nodus et folium piceae Meyeri (Nodus et Folium Piceae Wilsonii), Semen seu Lignum Piceae wilsonii.[nature and flavor] are bitter; Puckery; Temperature.[function cures mainly] expelling wind and removing dampness; Activating collaterals to relieve pain.Main rheumatic arthritis; Treating swelling and pain by traumatic injury; Improving eyesight is calmed the nerves; Hypertension; Nyctalopia.[extracts] " China's book on Chinese herbal medicine "
Herba Tricyrtis Pilosae: [another name] founds bamboo root, Radix Tricyrtidis pilosae, Fructus Cucumidis sativi dish, Cucumber perfume, melon rice dish.[source] medical material Ji Yuan: be the herb of liliaceous plant Hemerocallis citrina Baroni Herba Tricyrtidis macropodae.[nature and flavor] are sweet; Cold nature.[function cures mainly] clearing heat and relieving fidgetness; Promoting blood circulation and detumescence.Main gastric heat is thirsty; Dysphoria; Impairment caused by overstrain; Edema.[extracts] " China's book on Chinese herbal medicine "
Herba Pellioniae repentis: [another name] tells Nicotiana tabacum L..[source] medical material Ji Yuan: be the herb of contrayerva Herba Pellioniae repentis.[nature and flavor] are sweet; Micro-puckery; Cool in nature.[return through] liver; The heart; Spleen channel.[function cures mainly] clearing away heat-damp and promoting diuresis; Mind tranquilizing and the heart calming.Main damp and hot yellow cellulitis; Ascites; Insomnia; Forgetful; Allergic dermatitis; Ulcer of the lower limb; Furuncle toxic swelling.[extracts] " China's book on Chinese herbal medicine "
Fructus Choerospondiatis: [another name] five fruits, Fructus Choerospondiatis, Fructus Dracontomeli Duperreani, winter east, Ziziphi Spinosae, mountain eucalyptus globulus fruit, nasal mucus fruit, Fructus Choerospondiatis, acetic acid fruit.[nature and flavor] sweet in the mouth; Acid; Property is put down.[return through] spleen; Liver Channel.[function cures mainly] promoting flow of QI and blood; Tranquilizing by nourishing the heart; Removing food stagnancy; Removing toxic substances.Main qi depression to blood stasis; Chest pain; Shortness of breath and palpitation; Neurasthenia; Insomnia; Bronchitis; Dyspepsia abdominal distention; Diarrhoea; Hernia; Burn and scald.[extracts] " China's book on Chinese herbal medicine "
Medulla Junci: [another name] dragon palpus, careless Radix Dipsaci, Herba Tubocapsici Anomali, imperial temples, Medulla Junci, grass poison, Longhua, outstanding Tu, Herba Poae Sphondylodis, Jinyun grass, Long Xiu, Xuan Guan, Fang Bin, seat grass, careless, the wild seat grass of beard.[source] medical material Ji Yuan: be the herb of the wild Medulla Junci of rush family plant.[nature and flavor] are bitter; Cool.[return through] heart; Small intestine meridian.[function cures mainly] relieving stranguria by diuresis; Expel the heat-evil; Calm the nerves; Cooling blood for hemostasis.Main pyretic stranguria; Oedema due to nephritis; Heat in the heart is irritated; Palpitation and insomnia; Aphtha of the mouth and tongue; Pharyngalgia; Toothache; Conjunctival congestion and swelling pain; Epistaxis; Spitting of blood; Hematuria.[extracts] " China's book on Chinese herbal medicine "
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba Salsolae Collinae 10 ~ 20 parts, Rhizoma Ginseng 20 ~ 30 parts, Lysimachia trientaloides Hemsl. 10 ~ 20 parts, telegraph plant 10 ~ 20 parts, 10 ~ 20 parts, Strobilus Cupressi 20 ~ 30 Fen ， Wilsonii wood, Herba Tricyrtis Pilosae 10 ~ 20 parts, Herba Pellioniae repentis 20 ~ 30 parts, Fructus Choerospondiatis 10 ~ 20 parts and Medulla Junci 15 ~ 25 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba Salsolae Collinae 13 ~ 18 parts, Rhizoma Ginseng 20 ~ 25 parts, Lysimachia trientaloides Hemsl. 10 ~ 15 parts, telegraph plant 12 ~ 17 parts, 15 ~ 20 parts, Strobilus Cupressi 25 ~ 30 Fen ， Wilsonii wood, Herba Tricyrtis Pilosae 13 ~ 18 parts, Herba Pellioniae repentis 20 ~ 25 parts, Fructus Choerospondiatis 10 ~ 15 parts and Medulla Junci 18 ~ 23 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Salsolae Collinae 16 parts, Rhizoma Ginseng 22 parts, Lysimachia trientaloides Hemsl. 14 parts, telegraph plant 12 parts, 16 parts, Strobilus Cupressi 28 Fen ， Wilsonii wood, Herba Tricyrtis Pilosae 18 parts, Herba Pellioniae repentis 22 parts, Fructus Choerospondiatis 14 parts and Medulla Junci 20 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Salsolae Collinae 14 parts, Rhizoma Ginseng 25 parts, Lysimachia trientaloides Hemsl. 12 parts, telegraph plant 16 parts, 18 parts, Strobilus Cupressi 25 Fen ， Wilsonii wood, Herba Tricyrtis Pilosae 15 parts, Herba Pellioniae repentis 25 parts, Fructus Choerospondiatis 10 parts and Medulla Junci 22 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:
The first step, by Herba Salsolae Collinae, Rhizoma Ginseng, Lysimachia trientaloides Hemsl., telegraph plant, Fructus Choerospondiatis and Medulla Junci mixing, add relative to mixture 4 ~ 8 times amount determining alcohol be 75% ~ 85% alcohol reflux 2 ~ 4 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;
3rd step, the mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, carries out mixing by described dried cream powder and starch and processes, obtain mastic mixture; Described mastic and the weight ratio of starch are 1: 0.02 ~ 0.03; Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained;
5th step, described mastic compound particles and Pulvis Talci, magnesium stearate are carried out successively mixing processes, tabletting process, Cotton seeds, obtain Chinese medicine preparation tablet finished product; The weight ratio of described granule, Pulvis Talci, magnesium stearate is 100: 1 ~ 3: 0.15 ~ 0.3.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is glucose injection, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.
Embodiment 1: tablet
Get Herba Salsolae Collinae 140g, Rhizoma Ginseng 250g, Lysimachia trientaloides Hemsl. 120g, telegraph plant 160g, Strobilus Cupressi 250g ， Wilsonii wood 180g, Herba Tricyrtis Pilosae 150g, Herba Pellioniae repentis 250g, Fructus Choerospondiatis 100g and Medulla Junci 220g;
Its preparation method comprises the following steps:
The first step, by Herba Salsolae Collinae, Rhizoma Ginseng, Lysimachia trientaloides Hemsl., telegraph plant, Fructus Choerospondiatis and Medulla Junci mixing, add relative to mixture 6 times amount determining alcohol be 80% alcohol reflux 3 times, each 3 hours, filter, filtrate merges, and reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 times of water gagings, boils 3 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.28;
3rd step, the mastic mixing that the first step, second step are obtained, 60 DEG C of reduced vacuum dryings, get dry extract powder;
4th step, carries out mixing by described dried cream powder and starch and processes, obtain mastic mixture; Described mastic and the weight ratio of starch are 1: 0.03; Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained;
5th step, described mastic compound particles and Pulvis Talci, magnesium stearate are carried out successively mixing processes, tabletting process, Cotton seeds, obtain Chinese medicine preparation tablet finished product; The weight ratio of described granule, Pulvis Talci, magnesium stearate is 100: 2.4: 0.25.
Embodiment 2: glucose injection
Get Herba Salsolae Collinae 160g, Rhizoma Ginseng 220g, Lysimachia trientaloides Hemsl. 140g, telegraph plant 120g, Strobilus Cupressi 280g ， Wilsonii wood 160g, Herba Tricyrtis Pilosae 180g, Herba Pellioniae repentis 220g, Fructus Choerospondiatis 140g and Medulla Junci 200g;
Prepare according to the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 6 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 4 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 hours under the condition of 5 DEG C, adopt percolation with the speed of 1ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 50 minutes at this, the micron particles of acquisition 1 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets the mixed powder 15g that second step obtains, adds propylene glycol 35g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g needle-use activated carbon, fully stirs 50 minutes; Decarbonization filtering; With 0.22 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
Toxicity test:
Acute toxicity testing: application mice 60, male and female half and half, body weight 20 ~ 30g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicinal tablet prepared by embodiments of the invention 1, (concentration is 7.30g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 36.5 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>36.5 crude drug/kg of the present invention, every day, maximum dosage-feeding was 73.0 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 6.4g crude drug/day/people, adult body weight in 60KG, average dosage is 0.107g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 25g) oral administration gavage Chinese medicine of the present invention is 682 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine embodiment 1 tablet of the present invention to three groups of mices (often organize 20) by 13.12,19.03 and 37.45g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection: whole 100 routine cases are the pregnant patient of my institute's termination of pregnancy, patient is divided into experimental group and matched group at random, wherein experimental group 50 people, 22 ~ 35 years old age, mean age (25.2 ± 1.9) year, average pregnancy cycle (7.6 ± 1.8) week; Matched group 50 people, 23 ~ 37 years old age, the mean age (25.6 ± 2.1) year, average pregnancy cycle (7.7 ± 1.6) week.Two groups of ages, the equal not statistically significant of pregnancy cycle comparing difference (p>0.05).All anemia of pregnant woman are healthy pregnant women, perfect without cardio-pulmonary function medical history, kidney medical history, liver function, without anesthesia contraindication, turn out to be in utero pregnant through Visual quality inspection.
Experimental technique: two groups of anemia of pregnant woman fasting 4 ~ 6 hours in the preoperative, sets up venous access before anesthesia, detects maternal heart rate, blood pressure, keep anemia of pregnant woman's smooth breathing.
Matched group: first with 10ml normal saline, the fentanyl of 3mg/kg is diluted to intravenous injection liquid, 30s injects complete, to have pushed away after 2min intravenous injection 2mg/kg propofol again, observed anemia of pregnant woman's reaction, caused that anemia of pregnant woman occurs that expression in the eyes stagnates, loss of eyelash reflex time can start operation.
Experimental group: operation consent 2 hours oral 4, the embodiment of the present invention 1 tablets, then first with 10ml normal saline, the fentanyl of 3mg/kg is diluted to intravenous injection liquid, 30s injects complete, to push away after 2min intravenous injection 2mg/kg propofol again, observe anemia of pregnant woman reaction, cause anemia of pregnant woman occur expression in the eyes stagnate, loss of eyelash reflex time can start operation.
Two groups of anaesthetics inject speed according to anemia of pregnant woman's clinical response, and be advisable without activity without groan and limbs to maintain anemia of pregnant woman, to end of performing the operation, the rear operation analgesic effect to two groups of having performed the operation carries out statistical.
Monitoring index: monitor in preoperative, art and postoperative 10min maternal heart rate, blood pressure, blood oxygen saturation and breath state, observe anesthesia duration and postoperative untoward reaction, prepares crash equipment with for subsequent use in operating room, the monitoring of anaesthetist's whole process.
Evaluation criterion: operation analgesic effect is divided into 3 grades: effective: completely painless in anemia of pregnant woman's art, after question closely memoryless, coordinate completely.Effective: small size limb activity in anemia of pregnant woman's art, expression is slightly painful, but can keep coordinating.Invalid: significantly limb activity in anemia of pregnant woman's art, painful groan, cannot coordinate operation, must add anaesthesia dosage or change anaesthetic.
Result: operation analgesic effect compares, in table 1.Anesthesia duration compares with untoward reaction, in table 2.
Table 1: two groups of corrective surgery analgesic effects compare
| Group | n | Effective | Effectively | Invalid | Effectively total |
| Experimental group | 50 | 46(92％) | 4(8％) | 0 | 50(100％) |
| Matched group | 50 | 35(70％) | 15(30％) | 0 | 50(100％) |
Table 1 shows, and experimental group analgesic effect is better than matched group, can significantly improve obvious effective rate, and namely Chinese medicine of the present invention obviously can strengthen the analgesia effect of traditional anaesthetic.
Table 2: two groups of patient's anesthesia durations compare with untoward reaction
| Group | n | Anesthesia duration/min | Untoward reaction number of cases (%) |
| Experimental group | 50 | 7.36±2.83 | 8(16％) |
| Matched group | 50 | 9.15±1.83 | 26(52％) |
Table 2 shows, and experimental group is compared with matched group, and the anesthesia duration of experimental group is shorter than matched group, and the untoward reaction of experimental group is also starkly lower than matched group.Experimental group only has 8 routine patients that the untoward reaction such as postoperative blurring of vision, dizzy, tired or postoperative vomiting occur, and do not do any process, after postoperative 4 ~ 6h, symptom is died away; And matched group has 26 routine patients that the untoward reaction such as postoperative spasm, postoperative vomiting occur, need give with patient's spasmolytic, anti-emetic thing after symptom can disappear, two groups of comparing differences have statistical significance (P<0.05).
Anesthesia Monitoring result: matched group Most patients heart rate, blood pressure in operation process decline to some extent, but all in safety range, wherein 2 routine anemia of pregnant woman also occur that respiratory arrest continues 10 ~ 15 seconds after being anesthetized, but recover all voluntarily.And experimental group only has 3 routine anemia of pregnant woman to occur tachycardic situation, have no other significant changes.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (9)
1. a Chinese medicine for painless induced abortion, is characterized in that, each raw medicinal material of described Chinese medicine comprises: Herba Salsolae Collinae, Rhizoma Ginseng, Lysimachia trientaloides Hemsl., telegraph plant, Strobilus Cupressi, Wilsonii wood, Herba Tricyrtis Pilosae, Herba Pellioniae repentis, Fructus Choerospondiatis and Medulla Junci.
2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Salsolae Collinae 10 ~ 20 parts, Rhizoma Ginseng 20 ~ 30 parts, Lysimachia trientaloides Hemsl. 10 ~ 20 parts, telegraph plant 10 ~ 20 parts, 10 ~ 20 parts, Strobilus Cupressi 20 ~ 30 Fen ， Wilsonii wood, Herba Tricyrtis Pilosae 10 ~ 20 parts, Herba Pellioniae repentis 20 ~ 30 parts, Fructus Choerospondiatis 10 ~ 20 parts and Medulla Junci 15 ~ 25 parts.
3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Salsolae Collinae 13 ~ 18 parts, Rhizoma Ginseng 20 ~ 25 parts, Lysimachia trientaloides Hemsl. 10 ~ 15 parts, telegraph plant 12 ~ 17 parts, 15 ~ 20 parts, Strobilus Cupressi 25 ~ 30 Fen ， Wilsonii wood, Herba Tricyrtis Pilosae 13 ~ 18 parts, Herba Pellioniae repentis 20 ~ 25 parts, Fructus Choerospondiatis 10 ~ 15 parts and Medulla Junci 18 ~ 23 parts.
4. the Chinese medicine as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Salsolae Collinae 16 parts, Rhizoma Ginseng 22 parts, Lysimachia trientaloides Hemsl. 14 parts, telegraph plant 12 parts, 16 parts, Strobilus Cupressi 28 Fen ， Wilsonii wood, Herba Tricyrtis Pilosae 18 parts, Herba Pellioniae repentis 22 parts, Fructus Choerospondiatis 14 parts and Medulla Junci 20 parts.
5. the Chinese medicine as described in Claims 1-4, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Salsolae Collinae 14 parts, Rhizoma Ginseng 25 parts, Lysimachia trientaloides Hemsl. 12 parts, telegraph plant 16 parts, 18 parts, Strobilus Cupressi 25 Fen ， Wilsonii wood, Herba Tricyrtis Pilosae 15 parts, Herba Pellioniae repentis 25 parts, Fructus Choerospondiatis 10 parts and Medulla Junci 22 parts.
6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:
The first step, by Herba Salsolae Collinae, Rhizoma Ginseng, Lysimachia trientaloides Hemsl., telegraph plant, Fructus Choerospondiatis and Medulla Junci mixing, add relative to mixture 4 ~ 8 times amount determining alcohol be 75% ~ 85% alcohol reflux 2 ~ 4 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;
3rd step, the mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, carries out mixing by described dried cream powder and starch and processes, obtain mastic mixture; Described mastic and the weight ratio of starch are 1: 0.02 ~ 0.03; Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained;
5th step, described mastic compound particles and Pulvis Talci, magnesium stearate are carried out successively mixing processes, tabletting process, Cotton seeds, obtain Chinese medicine preparation tablet finished product; The weight ratio of described granule, Pulvis Talci, magnesium stearate is 100: 1 ~ 3: 0.15 ~ 0.3.
7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is glucose injection, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:
The first step, by Herba Salsolae Collinae, Rhizoma Ginseng, Lysimachia trientaloides Hemsl., telegraph plant, Fructus Choerospondiatis and Medulla Junci mixing, add relative to mixture 4 ~ 8 times amount determining alcohol be 75% ~ 85% alcohol reflux 2 ~ 4 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;
3rd step, the mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, carries out mixing by described dried cream powder and starch and processes, obtain mastic mixture; Described mastic and the weight ratio of starch are 1: 0.02 ~ 0.03; Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained;
5th step, described mastic compound particles and Pulvis Talci, magnesium stearate are carried out successively mixing processes, tabletting process, Cotton seeds, obtain Chinese medicine preparation tablet finished product; The weight ratio of described granule, Pulvis Talci, magnesium stearate is 100: 1 ~ 3: 0.15 ~ 0.3.
9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is glucose injection, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
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| CN104984069A (en) * | 2015-07-16 | 2015-10-21 | 黄炳江 | Traditional Chinese medicinal narcotic applied in painless abortion surgery, and preparation method thereof |
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Application publication date: 20160316 |