CN105267684A - Traditional Chinese medicine for treating chemotherapeutic phlebitis of tumor patients and preparation method thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine for treating chemotherapeutic phlebitis of tumor patients and a preparation method thereof. The traditional Chinese medicine is prepared from the following medicinal raw materials: agrimonia pilosa ledeb, leaves of jasminum nudiflorum, ficus pumila linn, helicia cochinchinensis, cephalanthera erecta, terminalia chebula retz, geranium wilfordii maxim, senecio jacobacea, lysimachia chiristinae hance, stemof falsetomentoseanther clematis, sorbus pohuashanensis, perfoliote knotweed herb, sweet iris flower, vernonia cinerea, gynura bicolor and changnienia amoena. The traditional Chinese medicine has the beneficial effects of safe use, no toxic or side effect, no allergic reaction, high efficiency and quick response, and can be used for quickly eliminating local heat and pain of a patient in 1-2 days and quickly eliminating red, swelling and the like of the patient in 2-3 days. The preparation process is simple.

Description

One treats the phlebitic Chinese medicine of Chemotherapy of Tumor Patients and preparation method

Technical field

The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to one and treat the phlebitic Chinese medicine of Chemotherapy of Tumor Patients and preparation method.

Background technology

Intravenous chemotherapy is one of important means for the treatment of malignant tumor at present.Because most of chemotherapeutics is chemistry or alkaloid formulations, toxicity is large, concentration is high, repeatedly, repeatedly, Large Dose Intravenous impacts the mechanical stimulus that causes of chemotherapy and the intense stimulus of high concentration medicine to local can cause administration vein and adjacent tissue is rubescent, swelling, pain, sclerosis of blood vessels etc., cause phlebitis.Phlebitis in various degree can be there is in the patients undergoing chemotherapy of 50%-80%.Chemotherapeutic phlebitis is one common in phlebitis, is one of toxicity of chemotherapeutic period, and it is because the toxicity of chemotherapeutics stimulates, and makes caused by vascular endothelial injury.Once generation phlebitis, not only cause suffering to patient, increase the work difficulty of medical personnel, increase medical expense, severe patient can affect carrying out smoothly of the chemotherapy cycles of patient, even makes limbs of patient function impaired.

The common main triggering factors of chemotherapeutic phlebitis has: 1, mechanical injuries: infusion process Zhong Wei strict implement sterile working, vein repeatedly penetration damage blood vessel endothelium or venous detaining needle retention time is long causes vein mechanical damage.Tumour patient repeatedly chemotherapy in a short time, carries out the blood vessel of chemotherapy by broken ring in addition, and venipuncture difficulty increases.If venipuncture one-time success rate is low or fixed needle position is improper also can increase mechanical injuries.2, chemotherapeutics damages the zest of vein: due to chronic infusion high concentration, chemotherapeutics that zest is stronger, and especially corrosivity chemotherapeutics injects peripheral vein, causes tunica intima of vein chemical injury in various degree.3, the hypercoagulability of malignant tumor patient: the malignant tumor patient of more than 50% and 90%, with the malignant tumor patient shifted, all exists the exception of one or more coagulation indexes.Because tumor h substance activates blood coagulation system clotting mechanism extremely directly or indirectly, chemotherapeutics can cause again tissue factor to discharge simultaneously, and fibrinolytic is suppressed, and the toxic action of medicine has increased the weight of tumor patient phlebitis and formed.

Therapeutic Method conventional at present has cold compress, drug blockage, local physical therapy, topical remedy's soak or external application etc., though there is certain therapeutical effect, curative effect is still not ideal.

The traditional Chinese medical science thinks that phlebitic mechanism is qi depression to blood stasis, and poison knot stagnates in blood vessels, causes local venation QI-blood circulation not smooth.Freely then do not become silted up, the stagnant resistance of congestion, stagnation of QI and blood may bring about pain; QI and blood is smooth, and the defeated cloth of body fluid is obstructed then swelling; Accumulate in blood stasis, accumulate heat-transformation of a specified duration, then local pyrexia; Venation is damaged, and it is rubescent blue to accumulate then local in blood oozing from the body openings or subcuta neous tissue skin or heat in blood.

Summary of the invention

Technical problem to be solved by this invention is, utilizes the theory of Chinese medical science that China is traditional, provides a kind of novel use safety, has no side effect, the phlebitic Chinese medicine for the treatment of Chemotherapy of Tumor Patients that effective percentage is high and preparation method.

In order to solve the problems of the technologies described above, the invention provides one and treat the phlebitic Chinese medicine of Chemotherapy of Tumor Patients, described Chinese medicine comprises following raw medicinal material: Herba Agrimoniae, Folium Jasmini Nudiflori, Fructus Fici Pumilae, Radix seu Folium Heliciae cochinchinensis, Cephalanthera ereota (Thunb.) Blume., Fructus chebulae immaturus, Herba Erodii, Herba Senecionis Argunensis, Herba Lysimachiae, Caulis Clematidis pseudopogonandrae, Fructus Sorbi Pohuashanensis, Herba Polygoni cymosi, Flos Iridis Chinensis, Herba Vernoniae Cinereae, gynura bicolor and Herba Changnieniae amoenae.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably: Herba Agrimoniae 10 ~ 20 parts, Folium Jasmini Nudiflori 20 ~ 30 parts, Fructus Fici Pumilae 5 ~ 15 parts, Radix seu Folium Heliciae cochinchinensis 15 ~ 25 parts, Cephalanthera ereota (Thunb.) Blume. 10 ~ 20 parts, Fructus chebulae immaturus 15 ~ 25 parts, Herba Erodii 20 ~ 30 parts, Herba Senecionis Argunensis 20 ~ 30 parts, Herba Lysimachiae 10 ~ 20 parts, Caulis Clematidis pseudopogonandrae 20 ~ 30 parts, Fructus Sorbi Pohuashanensis 15 ~ 25 parts, Herba Polygoni cymosi 20 ~ 30 parts, Flos Iridis Chinensis 10 ~ 20 parts, Herba Vernoniae Cinereae 20 ~ 30 parts, gynura bicolor 10 ~ 20 parts and Herba Changnieniae amoenae 20 ~ 30 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also more preferably: Herba Agrimoniae 15 ~ 20 parts, Folium Jasmini Nudiflori 20 ~ 25 parts, Fructus Fici Pumilae 8 ~ 13 parts, Radix seu Folium Heliciae cochinchinensis 17 ~ 22 parts, Cephalanthera ereota (Thunb.) Blume. 13 ~ 18 parts, Fructus chebulae immaturus 17 ~ 22 parts, Herba Erodii 25 ~ 30 parts, Herba Senecionis Argunensis 22 ~ 27 parts, Herba Lysimachiae 10 ~ 15 parts, Caulis Clematidis pseudopogonandrae 23 ~ 28 parts, Fructus Sorbi Pohuashanensis 18 ~ 23 parts, Herba Polygoni cymosi 22 ~ 27 parts, Flos Iridis Chinensis 12 ~ 17 parts, Herba Vernoniae Cinereae 20 ~ 25 parts, gynura bicolor 15 ~ 20 parts and Herba Changnieniae amoenae 25 ~ 30 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine also can more preferably: Herba Agrimoniae 18 parts, Folium Jasmini Nudiflori 22 parts, Fructus Fici Pumilae 12 parts, Radix seu Folium Heliciae cochinchinensis 18 parts, Cephalanthera ereota (Thunb.) Blume. 17 parts, Fructus chebulae immaturus 20 parts, Herba Erodii 28 parts, Herba Senecionis Argunensis 24 parts, Herba Lysimachiae 14 parts, Caulis Clematidis pseudopogonandrae 24 parts, Fructus Sorbi Pohuashanensis 22 parts, Herba Polygoni cymosi 24 parts, Flos Iridis Chinensis 14 parts, Herba Vernoniae Cinereae 20 parts, gynura bicolor 18 parts and Herba Changnieniae amoenae 26 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine also can more preferably: Herba Agrimoniae 16 parts, Folium Jasmini Nudiflori 24 parts, Fructus Fici Pumilae 10 parts, Radix seu Folium Heliciae cochinchinensis 22 parts, Cephalanthera ereota (Thunb.) Blume. 14 parts, Fructus chebulae immaturus 22 parts, Herba Erodii 25 parts, Herba Senecionis Argunensis 26 parts, Herba Lysimachiae 10 parts, Caulis Clematidis pseudopogonandrae 28 parts, Fructus Sorbi Pohuashanensis 20 parts, Herba Polygoni cymosi 26 parts, Flos Iridis Chinensis 16 parts, Herba Vernoniae Cinereae 24 parts, gynura bicolor 16 parts and Herba Changnieniae amoenae 28 parts.

When the dosage form of described Chinese medicine is granule, its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

When the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

Beneficial effect of the present invention: the Chinese medicine use safety that chemotherapeutic phlebitis of the present invention uses, to have no side effect, without anaphylaxis, effective percentage is high, instant effect, can eliminate the localized heat of patient, bitterly in 1-2 days fast, eliminate the red, swollen etc. of patient in 2-3 days fast, and preparation technology is simple.

Detailed description of the invention

The invention provides one and treat the phlebitic Chinese medicine of Chemotherapy of Tumor Patients, Chinese medicine comprises following raw medicinal material: Herba Agrimoniae, Folium Jasmini Nudiflori, Fructus Fici Pumilae, Radix seu Folium Heliciae cochinchinensis, Cephalanthera ereota (Thunb.) Blume., Fructus chebulae immaturus, Herba Erodii, Herba Senecionis Argunensis, Herba Lysimachiae, Caulis Clematidis pseudopogonandrae, Fructus Sorbi Pohuashanensis, Herba Polygoni cymosi, Flos Iridis Chinensis, Herba Vernoniae Cinereae, gynura bicolor and Herba Changnieniae amoenae.

The pharmacology of various raw medicinal material is as follows:

Herba Agrimoniae: [another name] Bud of hairyvein agrimony, Radix Agrimoniae, execute state Radix Agrimoniae, melon Rhizoma et radix valerianae, HUANGLONG tail, ferrum wasp, goldentop dragon bud, old stork mouth, primary and secondary grass, dry foot mattress, HUANGLONG tooth, grass fossilia dentis mastodi, Herba Thymi, Herba Malvastri Coromandeliani, Serpentis pimple, tap grass, very little eight joints, Lysimachia christinae Hance, dry foot chicken, Jerry flower, line MAZIHUA, Herba silenes fortunei, Folium Ainslaea Triflorae, Herba Blumeae Balsamiferae, ground Herba mesonae chinensis, Herba Lespedezae Cuneatae, roadside chicken, radix euphorbiae, chicken feet is husky, LUBIANHUANG, five hoof wind, ox head grass, dysentery grass, Folium seu radix sidae mysorensis, different wind neck grass, son is not from mother, father and son's grass, hair chicken grass, group orchid relieves internal heat grass, Indigofera pseudotinctoria, Folium Callicarpae Formosanae HUANGLONG tooth.[source] medical material Ji Yuan: be the aerial parts of rosaceous plant Agrimony.[nature and flavor] bitter in the mouth, puckery, property is put down.[return through] lung; Liver; Spleen channel.[function cures mainly] astringing to arrest bleeding, dysentery relieving, parasite killing.Main spitting of blood; Spit blood; Hematuria; Have blood in stool; Dysentery; Bleeding not during menses; Impairment caused by overstrain takes off power; Carbuncle; Traumatic injury; Wound hemorrhage.[extracts] " China's book on Chinese herbal medicine "

Folium Jasmini Nudiflori: [source] medical material Ji Yuan: for Oleaceae plants Flos Jasmini Nudiflori as leaf.[nature and flavor] are bitter; Cold in nature.[function cures mainly] heat clearing away; Dampness removing; Removing toxic substances.Main cold, fever; Urine leaching pain; Pruritus vulvae; Toxic swelling malignant boil; Traumatic injury; Knife injury is hemorrhage.[extracts] " China's book on Chinese herbal medicine "

Fructus Fici Pumilae: [another name] Fructus Fici Pumilae, water steamed bread, terrible steamed bread, climing head trailing plants, climb wall fruit, climb wall fruit, Semen Vaccariae, steamed bread Plantula Papaveris, bean jelly fruit, civilian head fruit, literary composition bulky, a sugared steamed bread, Mu Feng, Fructus Citri tangerinae handle, steamed bread youth, terrible ball, Fructus Manglietiae fordianae, bean jelly tree fruit, steamed bread fruit, Fructus Elaeagni Umbellatae, milk Fructus Citri grandis, Cheng Bangzi, wooden really Pu, Ficus prmua L. fruits, bean jelly, Fructus Chaenomelis, wing arm, swollen bubble, Corvus macrorhuchus steamed bread, cook lake.[source] medical material Ji Yuan: be the fruit of moraceae plants Xue Li.[nature and flavor] sweet in the mouth, property are flat.[return through] kidney, stomach, large intestine channel.[function cures mainly] tonifying the kidney to consolidate the essence; Clearing away heat-damp and promoting diuresis; Promoting blood circulation to restore menstrual flow; Lactogenic; Separate detumescence.Main emission due to deficiency of the kidney; YANG disease; Stranguria with turbid discharge; Chronic dysentery; Hemorrhoidal bleeding; Discharging fresh blood stool; Proctoptosis with chronic dysentery; Amenorrhea; Hernia; Agalactia; Throat pain; Mumps; Carbuncle; Scabies.[extracts] " China's book on Chinese herbal medicine "

Radix seu Folium Heliciae cochinchinensis: [another name] Weng Zaishu, fall dragsaw, the ten thousand dozens of rods, sheep miaow dung, Chinese olive tree, the young dung of sheep.[source] medical material Ji Yuan: be root or the leaf of Proteaceae plant fruitlet Eumeces Chinensis eye.[nature and flavor] are pungent; Bitter; Cool in nature.[function cures mainly] wind-expelling pain-stopping; Promoting blood circulation and detumescence; Astringing to arrest bleeding.Main rheumatic ostalgia; Traumatic injury congestive edema; Traumatic hemorrhage.[extracts] " China's book on Chinese herbal medicine "

Cephalanthera ereota (Thunb.) Blume.: [another name] fish head Cymbidium ensifolium (L.) Sw..[source] medical material Ji Yuan: be the herb of orchid Cephalanthera ereota (Thunb.) Blume..[nature and flavor] are sweet; Light; Cool.[return through] kidney; Urinary bladder channel.[function cures mainly] clearing away heat and promoting diuresis.Main high heat; Thirsty; Dysuria.[extracts] " China's book on Chinese herbal medicine "

Fructus chebulae immaturus: [another name] Tibet Fructus Canarii, FRUCTUS TERMINALIAE IMMATURUS.[source] medical material Ji Yuan: for Combretum Racemosum plant is the young fruit of Combretum Racemosum Fructus Chebulae.[nature and flavor] bitter in the mouth; Micro-sweet; Puckery; Cold nature.[function cures mainly] clearing away heat and promoting production of body fluid; Liyan jiedu.Main deficiency syndrome diphtheria; Tonsillitis; Bacillary dysentery; Dysentery; Enteritis.[extracts] " China's book on Chinese herbal medicine "

Herba Erodii: [another name] Herba Erodii, old official grass, five-petaled flowers, always pass through grass, Big Dipper grass, five leaf connection, Hydrocotyle sibthorpioides lam.Var.Batvachium (Hand.-Mazz.) et shan., crow muscle, pass through muscle, five tooth cakes, crow mouth, quail mouth.[source] medical material Ji Yuan: be the herb of MangNiu Er Seedling section plant Mang cattle Seedling, Herba Erodii, Siberia Herba Erodii, nepal cranesbill, tuber Herba Erodii band fruit.[nature and flavor] bitter in the mouth; Micro-pungent; Property is put down.[return through] spleen; Urinary bladder channel.[function cures mainly] dispelling wind and removing obstruction in the collateral; Invigorate blood circulation; Clearing away heat-damp and promoting diuresis.Main air pain of dampness syndrome; Numbness of the skin; Muscles and bones is miserable; Traumatic injury; Dysentery; Sore.[extracts] " China's book on Chinese herbal medicine "

Herba Senecionis Argunensis: [another name] Herba Senecionis Scandentis, large Herba Artemisiae Sieversianae.[source] medical material Ji Yuan: be root and the herb of feverfew Senecio argunensis.[nature and flavor] mildly bitter flavor; Cold in nature.[function cures mainly] heat-clearing and toxic substances removing; Liver heat removing and eyesight improving.Main dysentery; Coffee swells and ache; Conjunctival congestion; Carbuncle furuncle; Scrofula; Eczema; Scabies; Venom; Scorpion bee sting.[extracts] " China's book on Chinese herbal medicine "

Herba Lysimachiae: [another name] Lysimachia christinae Hance, DIWUGONG, Herba pteridis vittatae, Hydrocotyle vulgaris L., Herba cassiae torae, celestial being's Lysimachia christinae Hance, Lysimachia christinae, Herba Lysimachiae, Lysimachia christinae Hance, Yi Chuanqian, rescue temporarily, Herba Dichodrae, gong, money false aloe, rattan rattan Herba Houttuyniae, Herba Parnassiae foliosae root, copper coin flower, water Herba Houttuyniae, large Herba Glechomae, everywhere yellow, Hemerocallis citrina Baroni pass by one's way grass, imperial scale, very gold grass, Herba Seu Radix Tetrastigmatis Obtecti, floor file Lian Lian.[source] medical material Ji Yuan: be the herb of Ofthe Primulaceae Lysimachia christinae Hance.[nature and flavor] are sweet; Micro-hardship; Cool in nature.[return through] liver; Gallbladder; Kidney; Urinary bladder channel.[function cures mainly] relieving stranguria by diuresis; Heat-clearing and toxic substances removing; Dissipating blood stasis for subsidence of swelling.Main liver and gall and urinary system calculus; Pyretic stranguria; Oedema due to nephritis; Jaundice due to damp-heat; Sore carbuncle; Venom; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Caulis Clematidis pseudopogonandrae: [source] medical material Ji Yuan: be the ratan of ranunculaceae plant false palpus stamen Radix clematidis floridae.[nature and flavor] bitter in the mouth; Cold in nature.[return through] GUIXIN; Small intestinal; Urinary bladder channel.[function cures mainly] clearing away heat and promoting diuresis; Stimulating milk secretion.Main edema; Dysuria; Damp-heat gonorrhoea; Chronic dysentery; Aphtha of the mouth and tongue; Galactostasis.[extracts] " China's book on Chinese herbal medicine "

Fructus Sorbi Pohuashanensis: [another name] Ma Jiamu, the smelly Albizzia kalkora of Fructus Pyracanthae.[source] Rosaceae Sorbus plant Fructus Sorbi Pohuashanensis, with stem, peel of stem and fruit medicine.Autumn adopts, and dries.[nature and flavor] fruit: sweet, bitter is flat.Stem, peel of stem: bitter, cold.[function cures mainly] fruit: stomach invigorating tonify deficiency.For gastritis, Vitamin A, the third deficiency disease.Stem, peel of stem: clearing away lung-heat to relieve cough.For pulmonary tuberculosis, asthma, cough.[extracts] " national Chinese herbal medicine compilation "

Herba Polygoni cymosi: [another name] Herba Lespedezae Cuneatae, colter thorn, river Pennisetum centrasiaticum Tzvel, ant grasshopper le, urgency are separated element, tiger Lei, ram's horn thorn, Herba Polygoni cymosi, She Yacao, worn leaf knotweed.[source] passes through the herb of leaf knotweed for Polygonaceae arsesmart.Gather during summer fall planting strain riotous growth, dry.[nature and flavor] acid, cool.[function cures mainly] heat-clearing and toxic substances removing, inducing diuresis to remove edema.For upper respiratory tract infection, tracheitis, pertussis, acute tonsillitis, enteritis, dysentery, oedema due to nephritis; Herpes zoster is controlled in external, eczema, carbuncle furuncle and phyma poison, venom.[extracts] " national Chinese herbal medicine compilation "

Flos Iridis Chinensis: [another name] acute litchi flower, calabash shell serving as a dipper showy flowers of herbaceous plants, horse Flos meliae, hasty and careless leaf flower, non-irrigated Pu.[source] medical material Ji Yuan: the flower of irides Chinese small iris.[nature and flavor] micro-hardship; Pungent; Micro-sweet; Cold.[return through] returns stomach; Spleen; Lung; Liver Channel.[function cures mainly] heat-clearing and toxic substances removing; Cooling blood for hemostasis; Inducing diuresis for treating stranguria syndrome.Main sore throat; Spit blood; Epistaxis; Metrorrhagia; Have blood in stool; Stranguria; Hernia; Hemorrhoid; Carbuncle; Scald.[extracts] " China's book on Chinese herbal medicine "

Herba Vernoniae Cinereae: [another name] Herba Vernoniae Cinereae, XIAOSHANHU.[source] is Compositae Strepopelia orientalis platymiscium Herba Vernoniae Cinereae, with all herbal medicine.Xia Qiu gathers, and cleans using fresh herb or dries.[nature and flavor] are bitter, micro-sweet, cool.[function cures mainly] wind-dispelling heat-dissipating, removing pathogenic heat from blood and toxic substance from the body, calms the nerves.For cold, fever, cough, dysentery, icterohepatitis, neurasthenia; Carbuncle furuncle and phyma poison is controlled in external, venom.[extracts] " national Chinese herbal medicine compilation "

Gynura bicolor: [another name] red kind of Herba Amaranthi tricoloris, red hair kind, Radix seu Folium Alchorneae trewioidis, Herba Gynurae bicoloris, YEXIAHONG, carbuncle dish, blood skin dish, a blood dish, Radix Angelicae Sinensis dish, Begonia fimbristipula Hance, Herba basellae rubrae.[source] Compositae Herba Senecionis Chrysanthemoidis platymiscium gynura bicolor, is used as medicine with herb or stem, leaf.The whole year can adopt.Because stem, leaf are rich in water juice, be difficult to dry, general many using fresh herbs.[nature and flavor] are sweet, pungent, cool.[function cures mainly] cooling blood for hemostasis, clearing heat for detumescence.For hemoptysis, metrorrhagia, dysmenorrhea, vim and vigour pain, bronchitis, pelvic inflammatory disease, heatstroke, amebic dysentery; Wound hemorrhage is controlled in external, and ulcer does not close up for a long time, furuncle carbuncle, paronychia.[extracts] " national Chinese herbal medicine compilation "

Herba Changnieniae amoenae: [another name] Changuienia amoena Chien.[source] the orchid family Herba Changnieniae amoenae, is used as medicine with herb, root.[function cures mainly] heat clearing away, removing heat from blood, removing toxic substances.Cure mainly cough, sputum mixed with blood, furuncle furuncle.[extracts] " national Chinese herbal medicine compilation "

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably: Herba Agrimoniae 10 ~ 20 parts, Folium Jasmini Nudiflori 20 ~ 30 parts, Fructus Fici Pumilae 5 ~ 15 parts, Radix seu Folium Heliciae cochinchinensis 15 ~ 25 parts, Cephalanthera ereota (Thunb.) Blume. 10 ~ 20 parts, Fructus chebulae immaturus 15 ~ 25 parts, Herba Erodii 20 ~ 30 parts, Herba Senecionis Argunensis 20 ~ 30 parts, Herba Lysimachiae 10 ~ 20 parts, Caulis Clematidis pseudopogonandrae 20 ~ 30 parts, Fructus Sorbi Pohuashanensis 15 ~ 25 parts, Herba Polygoni cymosi 20 ~ 30 parts, Flos Iridis Chinensis 10 ~ 20 parts, Herba Vernoniae Cinereae 20 ~ 30 parts, gynura bicolor 10 ~ 20 parts and Herba Changnieniae amoenae 20 ~ 30 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also more preferably: Herba Agrimoniae 15 ~ 20 parts, Folium Jasmini Nudiflori 20 ~ 25 parts, Fructus Fici Pumilae 8 ~ 13 parts, Radix seu Folium Heliciae cochinchinensis 17 ~ 22 parts, Cephalanthera ereota (Thunb.) Blume. 13 ~ 18 parts, Fructus chebulae immaturus 17 ~ 22 parts, Herba Erodii 25 ~ 30 parts, Herba Senecionis Argunensis 22 ~ 27 parts, Herba Lysimachiae 10 ~ 15 parts, Caulis Clematidis pseudopogonandrae 23 ~ 28 parts, Fructus Sorbi Pohuashanensis 18 ~ 23 parts, Herba Polygoni cymosi 22 ~ 27 parts, Flos Iridis Chinensis 12 ~ 17 parts, Herba Vernoniae Cinereae 20 ~ 25 parts, gynura bicolor 15 ~ 20 parts and Herba Changnieniae amoenae 25 ~ 30 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine also can more preferably: Herba Agrimoniae 18 parts, Folium Jasmini Nudiflori 22 parts, Fructus Fici Pumilae 12 parts, Radix seu Folium Heliciae cochinchinensis 18 parts, Cephalanthera ereota (Thunb.) Blume. 17 parts, Fructus chebulae immaturus 20 parts, Herba Erodii 28 parts, Herba Senecionis Argunensis 24 parts, Herba Lysimachiae 14 parts, Caulis Clematidis pseudopogonandrae 24 parts, Fructus Sorbi Pohuashanensis 22 parts, Herba Polygoni cymosi 24 parts, Flos Iridis Chinensis 14 parts, Herba Vernoniae Cinereae 20 parts, gynura bicolor 18 parts and Herba Changnieniae amoenae 26 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine also can more preferably: Herba Agrimoniae 16 parts, Folium Jasmini Nudiflori 24 parts, Fructus Fici Pumilae 10 parts, Radix seu Folium Heliciae cochinchinensis 22 parts, Cephalanthera ereota (Thunb.) Blume. 14 parts, Fructus chebulae immaturus 22 parts, Herba Erodii 25 parts, Herba Senecionis Argunensis 26 parts, Herba Lysimachiae 10 parts, Caulis Clematidis pseudopogonandrae 28 parts, Fructus Sorbi Pohuashanensis 20 parts, Herba Polygoni cymosi 26 parts, Flos Iridis Chinensis 16 parts, Herba Vernoniae Cinereae 24 parts, gynura bicolor 16 parts and Herba Changnieniae amoenae 28 parts.

The present invention further provides again the preparation method of the phlebitic Chinese medicine of a kind of above-mentioned treatment Chemotherapy of Tumor Patients, and the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

The present invention further provides again the preparation method of the phlebitic Chinese medicine of a kind of above-mentioned treatment Chemotherapy of Tumor Patients, and the dosage form of described Chinese medicine is tablet, and it comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1: granule

Get Herba Agrimoniae 160g, Folium Jasmini Nudiflori 240g, Fructus Fici Pumilae 100g, Radix seu Folium Heliciae cochinchinensis 220g, Cephalanthera ereota (Thunb.) Blume. 140g, Fructus chebulae immaturus 220g, Herba Erodii 250g, Herba Senecionis Argunensis 260g, Herba Lysimachiae 100g, Caulis Clematidis pseudopogonandrae 280g, Fructus Sorbi Pohuashanensis 200g, Herba Polygoni cymosi 260g, Flos Iridis Chinensis 160g, Herba Vernoniae Cinereae 240g, gynura bicolor 160g and Herba Changnieniae amoenae 280g;

Its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 6 times, mixture is the ethanol of 95%, be heated to boiling reflux 3 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 55 DEG C subsequently under vacuum 0.08Mpa, relative density is the mastic of 1.05, spraying dry, the inlet temperature 170 DEG C of spray dryer, leaving air temp 80 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 times and 0.2 times in the dried cream powder obtained, makes granule, in 40 DEG C of dryings, obtains granule.

Embodiment 2: tablet

Get Herba Agrimoniae 180g, Folium Jasmini Nudiflori 220g, Fructus Fici Pumilae 120g, Radix seu Folium Heliciae cochinchinensis 180g, Cephalanthera ereota (Thunb.) Blume. 170g, Fructus chebulae immaturus 200g, Herba Erodii 280g, Herba Senecionis Argunensis 240g, Herba Lysimachiae 140g, Caulis Clematidis pseudopogonandrae 240g, Fructus Sorbi Pohuashanensis 220g, Herba Polygoni cymosi 240g, Flos Iridis Chinensis 140g, Herba Vernoniae Cinereae 200g, gynura bicolor 180g and Herba Changnieniae amoenae 260g;

Its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 85%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 times again, reflux 1.5 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 hour, pulverize, sieve, obtain 400 object micropowders;

3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.2 times, 0.1 times of lactose, the starch of 0.2 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.03 times of magnesium stearate, granulate, tabletting, makes.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 18-32g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine granules prepared by embodiments of the invention 1, (concentration is 8.64g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 43.2 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage granule LD50>43.2 crude drug/kg of the present invention, every day, maximum dosage-feeding was 86.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 8.52g crude drug/day/people, adult body weight in 60KG, average dosage is 0.142g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 25g) oral administration gavage Chinese medicine of the present invention is 608 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: the granule of Chinese medicine embodiment 1 of the present invention to three groups of mices (often organizing 20) by 13.26,25.42 and 42.38g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: all 100 routine cases all derive from this Out-patient Department and inpatient, all because of intravenous applications chemotherapeutics, phlebitis occur.Man 47 example, female 53 example, age 40-75 year, wherein 15 Lung cancer cases, gastric cancer 18 example, esophageal carcinoma 22 example, breast carcinoma 28 example, intestinal cancer 17 example.Be divided into treatment group and each 50 people of matched group at random, treatment group 50 people, man 24 example, female 26 example, age 40-72 year, wherein pulmonary carcinoma 8 example, gastric cancer 9 example, esophageal carcinoma 11 example, mammary cancer 14 example, intestinal cancer 8 example; I grade of 12 example, II grade of 22 example, III grade of 16 example.Matched group 50 people, man 23 example, female 27 example, age 41-75 year, wherein pulmonary carcinoma 7 example, gastric cancer 9 example, esophageal carcinoma 11 example, mammary cancer 14 example, intestinal cancer 9 example; I grade of 11 example, II grade of 22 example, III grade of 17 example.Treatment group and matched group be no significant difference (P > 0.05) on age and clinical symptoms, has comparability.

Diagnostic criteria: the diagnosis of chemotherapeutic phlebitis and classification are comparatively normal clinically at present, and what adopt is the standard of venous transfusion nurses association of the U.S.: 0 degree: transfusion part is without red, swollen, hot, bitterly and sense of discomfort.I grade: point of puncture local pain, red and swollen or edema, vein, without streak change, does not touch scleroma.II grade: point of puncture local pain, red and swollen or edema, vein has streak change, does not touch scleroma.III grade: point of puncture local pain, red and swollen or edema, vein has streak change, touches scleroma.

Therapeutic Method:

Treatment group: the granule of oral Chinese medicine embodiment 1 of the present invention, each 30g, every day 3 times.7 days courses for the treatment of.

Matched group: to be drenched by gauze with 33% Adlerika and directly spread on affected part afterwards, every 3-4h changes dressings 1 time, 7 days courses for the treatment of.

Meanwhile, vegetable and fruit diet and symptomatic treatment is kept two groups of every days.Treat and within first 1 week, stop using that all may affect the relevant medicine of test effect, and in therapeutic process, do not use medicine or the health product of other treatment chemotherapeutic phlebitis.

Curative effect judging standard: clinical cure: local skin is red, swollen, hot, pain transference cure, and the complete deliquescing of vein, changes without bar rope sample, and scleroma disappears.Effective: local skin is red, swollen, hot, pain transference cure, vein without scleroma, the deliquescing of bar rope sample red line, color reduction.Effective: localized heat, alleviation of pain are light, red, swollen area disappears >=and 60%, vein is without scleroma, and the deliquescing of bar rope sample red line, color does not go down.Invalid: disease is without improvement or improve less.

Therapeutic outcome: two groups treat 1 course for the treatment of respectively after, statistical result is see table 1 and table 2.

Table 1 liang group treats Clinical efficacy comparison (unit: example) after 1 course for the treatment of respectively

Group	Number of cases	Clinical cure	Effective	Effectively	Invalid	Total effective rate
							Treatment group	50	30	11	5	4	46(92％)
Matched group	50	20	9	9	10	40(80％)

As can be seen from Table 1, adopt treatment by Chinese herbs chemotherapeutic phlebitis of the present invention, relative to matched group on therapeutic effect, there is significant improvement.

After a table 2 liang group treats 1 course for the treatment of respectively, healing number and time compare (unit: example)

Group	Number of cases	Medication 3 days	Medication 5 days	Medication 7 days
					Treatment group	30	10(20％)	22(44％)	30(60％)
Matched group	20	6(12％)	12(24％)	20(40％)

As can be seen from Table 2, adopt treatment by Chinese herbs chemotherapeutic phlebitis of the present invention, relative to matched group, not only better efficacy, treatment the course for the treatment of on also can significantly shorten; Simultaneously according to clinical observation, medicine of the present invention can eliminate the localized heat, pain etc. of patient fast in 1-2 days, and 2-3 days interior quick elimination patients' is red, swollen etc.

According to the clinical statistics in toxicity test and above table, Chinese medicine provided by the invention have rapid-action, effective percentage is high, the advantage of safe without toxic side effect.

Concrete case: high certain, female, 57 years old, there is phlebitis in after chemotherapy 3 days in the intravenous chemotherapy because suffering from breast carcinoma, and according to point of puncture local pain, red and swollen or edema, vein has streak change, touches scleroma, is diagnosed as III chemotherapeutic phlebitis of 2 level and 3.The granule of the oral administration embodiment of the present invention 1, each 30g, every day 3 times, treat 2 days local skin heat, pain symptom is just basic disappears, treat that local skin after 5 days is red, swollen, hot, transference cure bitterly, the complete deliquescing of vein, change without bar rope sample, scleroma disappears, clinical cure, follows up a case by regular visits to 1 month without recurrence.

All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. the phlebitic Chinese medicine for the treatment of Chemotherapy of Tumor Patients, it is characterized in that, described Chinese medicine comprises following raw medicinal material: Herba Agrimoniae, Folium Jasmini Nudiflori, Fructus Fici Pumilae, Radix seu Folium Heliciae cochinchinensis, Cephalanthera ereota (Thunb.) Blume., Fructus chebulae immaturus, Herba Erodii, Herba Senecionis Argunensis, Herba Lysimachiae, Caulis Clematidis pseudopogonandrae, Fructus Sorbi Pohuashanensis, Herba Polygoni cymosi, Flos Iridis Chinensis, Herba Vernoniae Cinereae, gynura bicolor and Herba Changnieniae amoenae.

2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba Agrimoniae 10 ~ 20 parts, Folium Jasmini Nudiflori 20 ~ 30 parts, Fructus Fici Pumilae 5 ~ 15 parts, Radix seu Folium Heliciae cochinchinensis 15 ~ 25 parts, Cephalanthera ereota (Thunb.) Blume. 10 ~ 20 parts, Fructus chebulae immaturus 15 ~ 25 parts, Herba Erodii 20 ~ 30 parts, Herba Senecionis Argunensis 20 ~ 30 parts, Herba Lysimachiae 10 ~ 20 parts, Caulis Clematidis pseudopogonandrae 20 ~ 30 parts, Fructus Sorbi Pohuashanensis 15 ~ 25 parts, Herba Polygoni cymosi 20 ~ 30 parts, Flos Iridis Chinensis 10 ~ 20 parts, Herba Vernoniae Cinereae 20 ~ 30 parts, gynura bicolor 10 ~ 20 parts and Herba Changnieniae amoenae 20 ~ 30 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba Agrimoniae 15 ~ 20 parts, Folium Jasmini Nudiflori 20 ~ 25 parts, Fructus Fici Pumilae 8 ~ 13 parts, Radix seu Folium Heliciae cochinchinensis 17 ~ 22 parts, Cephalanthera ereota (Thunb.) Blume. 13 ~ 18 parts, Fructus chebulae immaturus 17 ~ 22 parts, Herba Erodii 25 ~ 30 parts, Herba Senecionis Argunensis 22 ~ 27 parts, Herba Lysimachiae 10 ~ 15 parts, Caulis Clematidis pseudopogonandrae 23 ~ 28 parts, Fructus Sorbi Pohuashanensis 18 ~ 23 parts, Herba Polygoni cymosi 22 ~ 27 parts, Flos Iridis Chinensis 12 ~ 17 parts, Herba Vernoniae Cinereae 20 ~ 25 parts, gynura bicolor 15 ~ 20 parts and Herba Changnieniae amoenae 25 ~ 30 parts.

4. the Chinese medicine as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba Agrimoniae 18 parts, Folium Jasmini Nudiflori 22 parts, Fructus Fici Pumilae 12 parts, Radix seu Folium Heliciae cochinchinensis 18 parts, Cephalanthera ereota (Thunb.) Blume. 17 parts, Fructus chebulae immaturus 20 parts, Herba Erodii 28 parts, Herba Senecionis Argunensis 24 parts, Herba Lysimachiae 14 parts, Caulis Clematidis pseudopogonandrae 24 parts, Fructus Sorbi Pohuashanensis 22 parts, Herba Polygoni cymosi 24 parts, Flos Iridis Chinensis 14 parts, Herba Vernoniae Cinereae 20 parts, gynura bicolor 18 parts and Herba Changnieniae amoenae 26 parts.

5. the Chinese medicine as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba Agrimoniae 16 parts, Folium Jasmini Nudiflori 24 parts, Fructus Fici Pumilae 10 parts, Radix seu Folium Heliciae cochinchinensis 22 parts, Cephalanthera ereota (Thunb.) Blume. 14 parts, Fructus chebulae immaturus 22 parts, Herba Erodii 25 parts, Herba Senecionis Argunensis 26 parts, Herba Lysimachiae 10 parts, Caulis Clematidis pseudopogonandrae 28 parts, Fructus Sorbi Pohuashanensis 20 parts, Herba Polygoni cymosi 26 parts, Flos Iridis Chinensis 16 parts, Herba Vernoniae Cinereae 24 parts, gynura bicolor 16 parts and Herba Changnieniae amoenae 28 parts.

6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

8. a preparation method for the Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

9. a preparation method for the Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.