CN105125714A - Traditional Chinese medicine preparation for treating chemotherapeutic phlebitis and preparing method thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine preparation for treating chemotherapeutic phlebitis and a preparing method thereof. The traditional Chinese medicine preparation is prepared from gingium verum, flos sophorae, ambergris, chien briggsia herbs, malvastrum coromandelianum, Chinese brake herbs, narrow-leaved lindernia, plantain herbs, sunflower roots, aeschynomene indica linn, aristolochia moupinensis, milk thistle, sri lanka pouzolzia herbs, violajaponicalangsd, motherwort fruit, paniculate swallowwort roots, fruticose breynia juvenile branchlet and leaf, lygodium japonicum herbs, radix gaultheriae, achyranthes aspera and maifan mineral. The traditional Chinese medicine preparation has the advantages of being safe to use, free from toxic and side effects and allergic reaction and high in effective rate, taking effect fast, and being capable of eliminating symptoms such as redness, swelling, fever and pain of local skin of a patient fast in 1-3 days, and the preparing technology is simple.

Description

One treats chemotherapeutic phlebitic Chinese medicine preparation and preparation method thereof

Technical field

The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to one and treat chemotherapeutic phlebitic Chinese medicine preparation and preparation method thereof.

Background technology

Intravenous chemotherapy is one of important means for the treatment of malignant tumor at present.Because most of chemotherapeutics is chemistry or alkaloid formulations, toxicity is large, concentration is high, repeatedly, repeatedly, Large Dose Intravenous impacts the mechanical stimulus that causes of chemotherapy and the intense stimulus of high concentration medicine to local can cause administration vein and adjacent tissue is rubescent, swelling, pain, sclerosis of blood vessels etc., cause phlebitis.Phlebitis in various degree can be there is in the patients undergoing chemotherapy of 50%-80%.Chemotherapeutic phlebitis is one common in phlebitis, is one of toxicity of chemotherapeutic period, and it is because the toxicity of chemotherapeutics stimulates, and makes caused by vascular endothelial injury.Once generation phlebitis, not only cause suffering to patient, increase the work difficulty of medical personnel, increase medical expense, severe patient can affect carrying out smoothly of the chemotherapy cycles of patient, even makes limbs of patient function impaired.

The common main triggering factors of chemotherapeutic phlebitis has: 1, mechanical injuries: infusion process Zhong Wei strict implement sterile working, vein repeatedly penetration damage blood vessel endothelium or venous detaining needle retention time is long causes vein mechanical damage.Tumour patient repeatedly chemotherapy in a short time, carries out the blood vessel of chemotherapy by broken ring in addition, and venipuncture difficulty increases.If venipuncture one-time success rate is low or fixed needle position is improper also can increase mechanical injuries.2, chemotherapeutics damages the zest of vein: due to chronic infusion high concentration, chemotherapeutics that zest is stronger, and especially corrosivity chemotherapeutics injects peripheral vein, causes tunica intima of vein chemical injury in various degree.3, the hypercoagulability of malignant tumor patient: the malignant tumor patient of more than 50% and 90%, with the malignant tumor patient shifted, all exists the exception of one or more coagulation indexes.Because tumor h substance activates blood coagulation system clotting mechanism extremely directly or indirectly, chemotherapeutics can cause again tissue factor to discharge simultaneously, and fibrinolytic is suppressed, and the toxic action of medicine has increased the weight of tumor patient phlebitis and formed.

Therapeutic Method conventional at present has cold compress, drug blockage, local physical therapy, topical remedy's soak or external application etc., though there is certain therapeutical effect, curative effect is still not ideal.

The traditional Chinese medical science thinks that phlebitic mechanism is qi depression to blood stasis, and poison knot stagnates in blood vessels, causes local venation QI-blood circulation not smooth.Freely then do not become silted up, the stagnant resistance of congestion, stagnation of QI and blood may bring about pain; QI and blood is smooth, and the defeated cloth of body fluid is obstructed then swelling; Accumulate in blood stasis, accumulate heat-transformation of a specified duration, then local pyrexia; Venation is damaged, and it is rubescent blue to accumulate then local in blood oozing from the body openings or subcuta neous tissue skin or heat in blood.

Summary of the invention

Technical problem to be solved by this invention is, utilizes the theory of Chinese medical science that China is traditional, provides a kind of novel use safety, has no side effect, the chemotherapeutic phlebitic Chinese medicine preparation for the treatment of that effective percentage is high and preparation method thereof.

In order to solve the problems of the technologies described above, the invention provides one and treat chemotherapeutic phlebitic Chinese medicine preparation, described Chinese medicine preparation comprises following raw medicinal material: Herba galii veri, Flos Sophorae, Ambra Grisea, Herba Briggsiae Chienii, Herba Malvastri Coromandeliani, Herba Pteridis Multifidae, Lindernia angustifolia (Benth.) Wettst., Herba Plantaginis, Radix Helianthi, Herba Aeschynonenes Indicae, Caulis aristolochiae moupinensis, Herba Silybi mariani, Herba Pouzolziae Zeylanicae, Herba Violae japonicae, Fructus Leonuri, Radix Cynanchi Paniculati, Folium et cacumen Breyniae Fruticosae, Herba lygodii, Caulis et folium gaultheriae yunnanensis, Radix Achyranthis and Maifanitum.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can be preferably: Herba galii veri 10 ~ 20 parts, 10 ~ 25 parts, Flos Sophorae, Ambra Grisea 10 ~ 30 parts, Herba Briggsiae Chienii 15 ~ 25 parts, Herba Malvastri Coromandeliani 10 ~ 25 parts, Herba Pteridis Multifidae 15 ~ 25 parts, Lindernia angustifolia (Benth.) Wettst. 10 ~ 25 parts, Herba Plantaginis 10 ~ 30 parts, Radix Helianthi 15 ~ 30 parts, Herba Aeschynonenes Indicae 10 ~ 25 parts, Caulis aristolochiae moupinensis 10 ~ 20 parts, Herba Silybi mariani 20 ~ 35 parts, Herba Pouzolziae Zeylanicae 20 ~ 30 parts, Herba Violae japonicae 10 ~ 20 parts, Fructus Leonuri 10 ~ 25 parts, Radix Cynanchi Paniculati 15 ~ 25 parts, Folium et cacumen Breyniae Fruticosae 10 ~ 20 parts, Herba lygodii 15 ~ 30 parts, Caulis et folium gaultheriae yunnanensis 10 ~ 20 parts, Radix Achyranthis 10 ~ 25 parts and Maifanitum 10 ~ 20 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also more preferably: Herba galii veri 10 ~ 15 parts, 15 ~ 25 parts, Flos Sophorae, Ambra Grisea 20 ~ 30 parts, Herba Briggsiae Chienii 15 ~ 20 parts, Herba Malvastri Coromandeliani 15 ~ 20 parts, Herba Pteridis Multifidae 20 ~ 25 parts, Lindernia angustifolia (Benth.) Wettst. 15 ~ 20 parts, Herba Plantaginis 20 ~ 30 parts, Radix Helianthi 20 ~ 30 parts, Herba Aeschynonenes Indicae 15 ~ 20 parts, Caulis aristolochiae moupinensis 15 ~ 20 parts, Herba Silybi mariani 20 ~ 30 parts, Herba Pouzolziae Zeylanicae 20 ~ 25 parts, Herba Violae japonicae 15 ~ 20 parts, Fructus Leonuri 10 ~ 20 parts, Radix Cynanchi Paniculati 15 ~ 20 parts, Folium et cacumen Breyniae Fruticosae 15 ~ 20 parts, Herba lygodii 20 ~ 30 parts, Caulis et folium gaultheriae yunnanensis 15 ~ 20 parts, Radix Achyranthis 15 ~ 25 parts and Maifanitum 15 ~ 20 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation also can more preferably: Herba galii veri 13 parts, 20 parts, Flos Sophorae, Ambra Grisea 25 parts, Herba Briggsiae Chienii 18 parts, Herba Malvastri Coromandeliani 18 parts, Herba Pteridis Multifidae 22 parts, Lindernia angustifolia (Benth.) Wettst. 18 parts, Herba Plantaginis 25 parts, Radix Helianthi 26 parts, Herba Aeschynonenes Indicae 18 parts, Caulis aristolochiae moupinensis 15 parts, Herba Silybi mariani 27 parts, Herba Pouzolziae Zeylanicae 23 parts, Herba Violae japonicae 16 parts, Fructus Leonuri 15 parts, Radix Cynanchi Paniculati 18 parts, Folium et cacumen Breyniae Fruticosae 16 parts, Herba lygodii 25 parts, Caulis et folium gaultheriae yunnanensis 16 parts, Radix Achyranthis 20 parts and Maifanitum 15 parts.

When the dosage form of described Chinese medicine preparation is liniment, its preparation method comprises the following steps:

Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 200 mesh sieves, the enable fine powder amount by 200 mesh sieves at least reaches 60%, collects and obtains fine powder a by the fine powder of 200 mesh sieves;

Step 2: the coarse powder not by 200 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds weight portion 8-10 times amount soak by water 1-3 hour, filters and obtains decocting liquid; Second time adds weight portion 6-10 times amount soak by water 1-3 hour, filters and obtains decocting liquid; Merge twice decocting liquid, filter to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;

Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.

When the dosage form of described Chinese medicine preparation is capsule, its preparation method comprises the following steps:

The first step, Herba galii veri, Flos Sophorae, Ambra Grisea, Herba Briggsiae Chienii, Herba Malvastri Coromandeliani, Herba Pteridis Multifidae and Lindernia angustifolia (Benth.) Wettst. are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 75 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;

Second step, Herba Aeschynonenes Indicae, Caulis aristolochiae moupinensis, Herba Silybi mariani, Herba Violae japonicae, Fructus Leonuri, Radix Cynanchi Paniculati and Herba lygodii are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 8 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.

Beneficial effect of the present invention: the Chinese medicine preparation use safety that chemotherapeutic phlebitis of the present invention uses, to have no side effect, without anaphylaxis, effective percentage is high, instant effect, the symptoms such as the local skin can eliminating patient in 1-3 days is fast red, swollen, hot, pain, and preparation technology is simple.

Detailed description of the invention

The invention provides one and treat chemotherapeutic phlebitic Chinese medicine preparation, Chinese medicine preparation comprises following raw medicinal material: Herba galii veri, Flos Sophorae, Ambra Grisea, Herba Briggsiae Chienii, Herba Malvastri Coromandeliani, Herba Pteridis Multifidae, Lindernia angustifolia (Benth.) Wettst., Herba Plantaginis, Radix Helianthi, Herba Aeschynonenes Indicae, Caulis aristolochiae moupinensis, Herba Silybi mariani, Herba Pouzolziae Zeylanicae, Herba Violae japonicae, Fructus Leonuri, Radix Cynanchi Paniculati, Folium et cacumen Breyniae Fruticosae, Herba lygodii, Caulis et folium gaultheriae yunnanensis, Radix Achyranthis and Maifanitum.

The pharmacology of various raw medicinal material is as follows:

Herba galii veri: [another name] cattle clothing, ferrum chi grass, menstruation is careless, Semen setariae is colored, willow husband floss Artemisia, furunculosis Artemisia, eritrichium pedumculare.[source] medical material Ji Yuan: be the herb of Maguireothamnus speciosus Herba galii veri.[nature and flavor] are micro-pungent; Bitter; Be slightly cold.[function cures mainly] heat-clearing and toxic substances removing; Promoting blood circulation to restore menstrual flow; Dispelling wind for relieving itching.Main hepatitis; Ascites; Laryngopharynx swelling and pain; Furuncle toxic swelling; Traumatic injury; Women's amenorrhea; Leukorrhagia; Venom; Honor measles; Paddy field dermatitis.[extracts] " China's book on Chinese herbal medicine "

Flos Sophorae: [another name] golden loblolly tree, Hu Fangshu, bean Chinese scholartree, the Flos Sophorae Immaturus.[source] this product is the dry flower and alabastrum of leguminous plant Chinese scholartree.[nature and flavor] are bitter, are slightly cold.[return through] returns liver, large intestine channel.[function cures mainly] cooling blood for hemostasis, purging liver-fire.For having blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, spit blood, epistaxis, liver-heat conjunctival congestion, has a headache dizzy.[extracts] " Chinese Pharmacopoeia "

Ambra Grisea: [another name] Long Spittle, imperial abdomen perfume, sperm whale, doegling, physeter.[source] medical material Ji Yuan: for the foreign body in intestine of physeterid sperm whale is as the secretions of the stimulation intestinals such as sepiellae seu sepiae mouthpart and other food debriss.[nature and flavor] sweet in the mouth; Acid; Puckery; Warm in nature; [return through] heart; Liver; Lung; Kidney channel.[function cures mainly] resolving phlegm and relieving asthma; Promoting QI to circulate and dispersing the agglomeration of the pathogens; Relieving stranguria by diuresis.Main QI rising in reverse order of breathing with cough; Uncomfortable in chest depressed; Lump in the abdomen; Trusted subordinate's pain; Coma; Stranguria.[extracts] " China's book on Chinese herbal medicine "

Herba Briggsiae Chienii: [another name] East China Buddhist, tripe lettuce tongue, rock green vegetable, Fossilia Spiriferis Radix Notoginseng, Herba Melicae Scabrosae, Budgerigar, Rhizoma Seu Herba Bergeniae, little lotus grass.[source] medical material Ji Yuan: be root or the herb of Anhui, Gesneriaceae Zhejiang thick cylinder lettuce tongue.[nature and flavor] mildly bitter flavor; Property is put down.[function cures mainly] expelling pathogenic wind from the body surface; To invigorate blood circulation eliminating carbuncle.Main headache due to common cold; Impairment caused by overstrain; Muscles and bones is ached; Carbuncle skin ulcer; Innominate toxic swelling.[extracts] " China's book on Chinese herbal medicine "

Herba Malvastri Coromandeliani: [source] medical material Ji Yuan: be the herb of Malvaceae plant Herba Malvastri Coromandeliani.[nature and flavor] are micro-sweet; Cool; [return through] lung; Liver; Large intestine channel.[function cures mainly] clearing away heat-damp and promoting diuresis; Removing toxic substances and promoting subsidence of swelling.Main damp-heat dysentery; Jaundice; Cough due to lung-heat; Laryngopharynx swelling and pain; Hemorrhoid; Carbuncle sore tumefacting virus; Traumatic injury; Before split each of adenitis .[discussion] " Guangxi Chinese herbal medicine ": clearing away heat-damp and promoting diuresis, blood stasis removing subside a swelling.To harness the Yellow River subcutaneous ulcer, dysentery, malaria, children's's dyspepsia, cough due to lung-heat, laryngitis, furuncle, treating swelling and pain by traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Herba Pteridis Multifidae: [source] medical material Ji Yuan: be herb or the root of Pteridaceae plant Herba Pteridis Multifidae.[nature and flavor] are light; Micro-hardship; Cold; [return through] large intestine; The heart; Liver Channel.[function cures mainly] clearing away heat-damp and promoting diuresis; Cooling blood for hemostasis; Subduing swelling and detoxicating.Main dysentery; Have loose bowels; Stranguria with turbid discharge; Leukorrhagia; Jaundice; Furuncle swelling toxin; Sore throat tonsillitis; Lymphoid tuberculosis; Parotitis; Mastitis; High fever tic; Snake bite and insect sting; Spit blood; Epistaxis; Hematuria; Have blood in stool; Traumatic hemorrhage.[each discussion] " the SHENGCAO property of medicine is standby to be wanted ": wash infantile malnutrition, furuncle, hemorrhoid, loose poison, applies skin ulcer.Control Serpentis and sting all poison, knife injury, energy hemostasia and promoting granulation, spring juice rectification clothes, slag applies affected part.Grinding into powder harvests and store controls pain due to disorder of QI." classifying herbal ": control all pyretic toxicity, detumescence, relieves inflammation or internal heat.Control carbuncle skin ulcer, acute mastitis, stranguria." illustrated handbook planted by middle traditional Chinese medicines ": control scabies.Guangzhou army " conventional Chinese herbal medicine handbook ": heat clearing away, dampness removing, removing heat from blood.Control bacillary dysentery, enteritis, fever caused by exogenous pathogens, urinary tract infection, leucorrhea, parotitis, furuncle, eczema.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Lindernia angustifolia (Benth.) Wettst.: [source] medical material Ji Yuan: for being distributed in Hubei, Hunan, Guangdong, Guangxi, Guizhou, Yunnan.The herb of ginseng section plant Lindernia micrantha.[nature and flavor] acrid in the mouth; Bitter; Property is put down.Function cures mainly] clearing away heat-damp and promoting diuresis; Removing toxic substances and promoting subsidence of swelling.Main jaundice due to damp-heat; Have loose bowels; Dysentery; Laryngopharynx swelling and pain; Traumatic injury.Each discussion] " Guizhou medical herbs ": clearing away heat-damp and promoting diuresis, eliminating blood stasis to promote regeneration of blood.Jinjiang, Fujian Province " Chinese herbal medicine handbook ": heat-clearing and toxic substances removing, blood stasis dispelling removing heat from blood.[extracts] " China's book on Chinese herbal medicine "

Herba Plantaginis: [source] this product is the dry herb of Plantaginaceae plant Herba Plantaginis or Plantago depressa Willd.[nature and flavor] are sweet, cold.[return through] returns liver, kidney, lung, small intestine meridian.[function cures mainly] clearing away heat and promoting diuresis, eliminates the phlegm, removing heat from blood, removing toxic substances.For edema oliguria, the puckery pain of pyretic stranguria, heat-damp in summer dysentery, phlegm-heat cough, hematemesis and epistaxis, carbuncle sore tumefacting virus.[extracts] " Chinese Pharmacopoeia "

Radix Helianthi: [another name] Helianthus annuus L., Flos Galinsogae Parviflorae root, sunflower root.[source] medical material Ji Yuan: be the root of feverfew Helianthi.[nature and flavor] sweet in the mouth; Light; Cold nature; [return through] returns stomach; Urinary bladder channel.[function cures mainly] clearing away heat-damp and promoting diuresis; Promoting the circulation of QI to relieve pain.Main stranguria with turbid discharge; Edema; Leukorrhagia; Hernia; Abdominal distention; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Herba Aeschynonenes Indicae: [source] medical material Ji Yuan: be the aerial parts of leguminous plant Herba Aeschynonenes Indicae.[nature and flavor] sweetness and bitterness; Cold; Nontoxic; [return through] lung; Stomach warp.[function cures mainly] clearing away heat-damp and promoting diuresis, dispelling pathogenic wind for improving eyesight, lactogenesis.Main pyretic stranguria, stranguria with blood, edema, has loose bowels, furuncle and phyma, skin ulcer scabies, conjunctival congestion and swelling pain, and look unfamiliar nebula, nyctalopia, arthralgia, and puerpera's breast is few.[each discussion] Guangzhou army " conventional Chinese herbal medicine handbook ": heat clearing away disappears stagnant.Control flatulence, dyspepsia, ache induced by gastritis, anemopyretic cold, eczema, dermatitis." Jiangxi medical herbs ": clearing away heat-damp and promoting diuresis, detumescence hemostasis.[extracts] " China's book on Chinese herbal medicine "

Caulis aristolochiae moupinensis: [another name] Huaihe River Caulis Akebiae, Caulis aristolochiae moupinensis Fructus Aristolochiae, reason Radix Stephaniae Tetrandrae, Radix Cocculi Orbiculati, rock see to be known.[source] medical material Ji Yuan: be ratan or the root of the stem of aristolochiaceae plant Baoxing Fructus Aristolochiae.[nature and flavor] are bitter; Pungent; Cold; [return through] heart; Kidney; Bladder; Small intestine meridian.[function cures mainly] clearing away heat-damp and promoting diuresis; Wind-expelling pain-stopping.Main dysentery stomachache; Hygropyretic edema; Hot urination; Hematuria; Beriberoid pyretic arthralgia; Carbuncle malignant boil; Eczema; Venom.[each discussion] " Yunnan Chinese herbal medicine ": removing damp-heat, evacuation of pus pain relieving.Control damp and hot dysuria, hematuria, trichomonas vaginitis, eczema, urticaria, rheumatic arthritis.[extracts] " China's book on Chinese herbal medicine "

Herba Silybi mariani: [another name] water flies Phasiana, Herba Silybi mariani, Lao Shu le.[source] medical material Ji Yuan: be the achene of feverfew Herba Silybi mariani.[nature and flavor] bitter in the mouth; Cool in nature.[function cures mainly] clearing away heat-damp and promoting diuresis; Depressed liver-energy dispersing and function of gallbladder promoting.Main chronic hepatitis; Liver cirrhosis fatty liver; Cholelithiasis; Cholangitis.[extracts] " China's book on Chinese herbal medicine "

Herba Pouzolziae Zeylanicae: [source] medical material Ji Yuan: for contrayerva fog band root is very removed from office entirely.[nature and flavor] are sweet; Light; Cold in nature.[function cures mainly] heat-clearing and toxic substances removing; Clear swollen evacuation of pus; Relieving stranguria by diuresis.Main pyogenic skin infection and carbuncle-abscess; Acute mastitis; Acute toothache; Dysentery; Diarrhoea; Urine leaching pain; Nebulousurine.[extracts] " China's book on Chinese herbal medicine "

Herba Violae japonicae: [source] medical material Ji Yuan: be the herb of Violaceae plant lobus cardiacus common violet.[nature and flavor] bitter in the mouth; Micro-pungent; Cold in nature; [return through] liver; Spleen channel.[function cures mainly] heat-clearing and toxic substances removing; Blood stasis dispelling evacuation of pus; Removing heat from blood liver heat removing.Main swollen ulcer drug; Acute mastitis; Acute appendicitis hematochezia; Suppurative osteomyelitis; Jaundice; Conjunctival congestion and swelling pain; Scrofula; Traumatic hemorrhage; Snakebite.[each discussion] " Zhiwu Mingshi Tukao ": root: control fiery disease, the same Herba Violae of merit." Zhejiang conventional medical herbs among the people ": heat clearing away, detumescence, removing toxic substances.[extracts] " China's book on Chinese herbal medicine "

Fructus Leonuri: [source] this product is the dry mature fruit of labiate Herba Leonuri.[nature and flavor] are pungent, bitter, are slightly cold.[return through] GUIXIN bag, Liver Channel.[function cures mainly] promoting blood flow to regulate menstruation, liver heat removing and eyesight improving.For menoxenia, amenorrhea, dysmenorrhea, cataract, dizzy distending pain.[extracts] " Chinese Pharmacopoeia "

Radix Cynanchi Paniculati: [source] medical material Ji Yuan: be root and rhizome or the whole herb with root of dicotyledon medicine asclepiadaceae plant Radix Cynanchi Paniculati.[nature and flavor] acrid in the mouth; Warm in nature.[return through] liver; Stomach warp.[function cures mainly] wind-expelling pain-stopping; Dispelling wind for relieving itching; Promoting blood circulation and detoxication; Unsting antipruritic; Detumescence.Main gastropathy; Toothache; Rheumatic arthralgia; Lumbago; Epigastric pain; Toothache; Urine water conservancy; Have loose bowels; Dysentery; Eczema; Urticaria; Venom.[each discussion] " expensive outer side's medicine collection among the people ": restore menstrual flow and invigorate blood circulation.Control red collapsing, leucorrhea.Guangzhou army " conventional Chinese herbal medicine handbook ": wind-expelling pain-stopping, removing toxic substances and promoting subsidence of swelling, promoting the flow of QI in the collateral by warming the meridian.Control venom, rheumatic ostalgia, heart peratodynia, treating swelling and pain by traumatic injury, herpes zoster, cirrhotic ascites, menoxenia, dysmenorrhea." Jilin Chinese herbal medicine ": diuresis, strong, sedation-analgesia, dissipating blood stasis of dispeling cold, antidotes against snake bite, dredging collateral and blood.Control beriberi, edema, ascites, distension, abdominal pain due to cold.[extracts] " China's book on Chinese herbal medicine "

Folium et cacumen Breyniae Fruticosae: [source] medical material Ji Yuan: be the browse of euphorbia plant Folium et cacumen Breyniae Fruticosae.[nature and flavor] mildly bitter flavor; Cool in nature; [return through] large intestine; Liver Channel.[function cures mainly] clearing heat and expelling damp; Promoting blood circulation and detoxication.Main stomachache is vomited and diarrhoea; Eczema; Herpes zoster; Dermatitis; Dermatitis rhus; Rheumatic arthralgia; Puerperal galactostasis; Pudendal pruritus.[extracts] " China's book on Chinese herbal medicine "

Herba lygodii: [source] medical material Ji Yuan: be the aerial parts of Lygodiaceae plant Spora Lygodii.[nature and flavor] are sweet; Cold; Nontoxic; [return through] small intestinal; Bladder; Liver Channel.[function cures mainly] heat-clearing and toxic substances removing; Relieving stranguria by diuresis; Promoting blood circulation to remove obstruction in the collateral.Main pyretic stranguria; Stranguria caused by urinary stone; Stranguria with blood; Dysuria; Edema; Nebulousurine; Leukorrhagia; Hepatitis; Have loose bowels; Dysentery; Cold, fever; Cough with asthma; Laryngopharynx swelling and pain; Aphtha; Conjunctival congestion and swelling pain; Mumps; Acute mastitis; Erysipelas; Herpes zoster; Burn due to hot liquid or fire; Skin pruritus; Traumatic injury wound is swollen; Rheumatic arthralgia; Traumatic hemorrhage.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Caulis et folium gaultheriae yunnanensis: [source] medical material Ji Yuan: be Herb or the root of ericad Caulis et folium gaultheriae yunnanensis.[nature and flavor] are pungent; Warm in nature; [return through] lung; Liver; Kidney channel.[function cures mainly] expelling wind and removing dampness; Dispersing cold for relieving pain; Promoting blood circulation to remove obstruction in the collateral; Preventing phlegm from forming and stopping coughing.Main air pain of dampness syndrome; Cold syndrome of the stomach pain; Traumatic injury; Cough ant phlegm.[each discussion] " the southern regions of the Yunnan Province book on Chinese herbal medicine ": control phlegm-fire, bones and muscles pain, steep in wine good with it.Its stalk, washes anemofrigid-damp arthralgia, bones and muscles pain, warm bone is diathermanous, endures washing." register planted by Guangxi medicine ": circulation of qi promoting, detumescence, relieving cough and resolving phlegm.Control toothache, impairment caused by overstrain, snakebite, rheumatism, eruptive disease, skin sufferings." Guizhou medical herbs ": expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation.[extracts] " China's book on Chinese herbal medicine "

Radix Achyranthis: [another name] Du Radix Achyranthis Bidentatae.[source] medical material Ji Yuan: be the root and rhizome of Radix Achyranthis Bidentatae on the wild species of amaranthaceous plant Radix Achyranthis Bidentatae and achyranthes longifolia Makino, the blunt leaf of coarse wool Radix Achyranthis Bidentatae.[nature and flavor] are sweet; Micro-hardship; Micro-acid; Cold in nature; [return through] liver; Kidney channel.[function cures mainly] blood circulation promoting and blood stasis dispelling; Eliminating fire and detoxication; Inducing diuresis for treating stranguria syndrome.Main amenorrhea; Traumatic injury; Rheumatic arthritis; Dysentery; Diphtheria; Laryngopharynx swelling and pain; Carbuncle sore; Stranguria; Edema.[extracts] " China's book on Chinese herbal medicine "

Maifanitum: [source] medical material Ji Yuan: be Acid-intermediate igneous rock rocks beschtauite.[nature and flavor] are sweet; Temperature; Nontoxic; [return through] liver; Stomach; Kidney channel.[function cures mainly] detoxicating and resolving stagnation of pathogens; Removing the necrotic tissue and promoting granulation; Except cold damp eliminating; The liver benefiting stomach invigorating; Blood circulation promoting and blood stasis dispelling; Diuresis fossil; Life lengthening.Main carbuncle carbuncle on the back; Acne; Eczema; Foot gas; Miliaria; Finger is chapped; Chloasma; Toothache; Oral ulcer; Rheumatic arthralgia; Lumbago and backache; Chronic hepatitis; Gastritis; Dysentery; Diabetes; Neurasthenia; Wound is red and swollen; Hypertension; Senile sclerosis of blood vessels; Tumor; Lithangiuria.[extracts] " China's book on Chinese herbal medicine "

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can be preferably: Herba galii veri 10 ~ 20 parts, 10 ~ 25 parts, Flos Sophorae, Ambra Grisea 10 ~ 30 parts, Herba Briggsiae Chienii 15 ~ 25 parts, Herba Malvastri Coromandeliani 10 ~ 25 parts, Herba Pteridis Multifidae 15 ~ 25 parts, Lindernia angustifolia (Benth.) Wettst. 10 ~ 25 parts, Herba Plantaginis 10 ~ 30 parts, Radix Helianthi 15 ~ 30 parts, Herba Aeschynonenes Indicae 10 ~ 25 parts, Caulis aristolochiae moupinensis 10 ~ 20 parts, Herba Silybi mariani 20 ~ 35 parts, Herba Pouzolziae Zeylanicae 20 ~ 30 parts, Herba Violae japonicae 10 ~ 20 parts, Fructus Leonuri 10 ~ 25 parts, Radix Cynanchi Paniculati 15 ~ 25 parts, Folium et cacumen Breyniae Fruticosae 10 ~ 20 parts, Herba lygodii 15 ~ 30 parts, Caulis et folium gaultheriae yunnanensis 10 ~ 20 parts, Radix Achyranthis 10 ~ 25 parts and Maifanitum 10 ~ 20 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also more preferably: Herba galii veri 10 ~ 15 parts, 15 ~ 25 parts, Flos Sophorae, Ambra Grisea 20 ~ 30 parts, Herba Briggsiae Chienii 15 ~ 20 parts, Herba Malvastri Coromandeliani 15 ~ 20 parts, Herba Pteridis Multifidae 20 ~ 25 parts, Lindernia angustifolia (Benth.) Wettst. 15 ~ 20 parts, Herba Plantaginis 20 ~ 30 parts, Radix Helianthi 20 ~ 30 parts, Herba Aeschynonenes Indicae 15 ~ 20 parts, Caulis aristolochiae moupinensis 15 ~ 20 parts, Herba Silybi mariani 20 ~ 30 parts, Herba Pouzolziae Zeylanicae 20 ~ 25 parts, Herba Violae japonicae 15 ~ 20 parts, Fructus Leonuri 10 ~ 20 parts, Radix Cynanchi Paniculati 15 ~ 20 parts, Folium et cacumen Breyniae Fruticosae 15 ~ 20 parts, Herba lygodii 20 ~ 30 parts, Caulis et folium gaultheriae yunnanensis 15 ~ 20 parts, Radix Achyranthis 15 ~ 25 parts and Maifanitum 15 ~ 20 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation also can more preferably: Herba galii veri 13 parts, 20 parts, Flos Sophorae, Ambra Grisea 25 parts, Herba Briggsiae Chienii 18 parts, Herba Malvastri Coromandeliani 18 parts, Herba Pteridis Multifidae 22 parts, Lindernia angustifolia (Benth.) Wettst. 18 parts, Herba Plantaginis 25 parts, Radix Helianthi 26 parts, Herba Aeschynonenes Indicae 18 parts, Caulis aristolochiae moupinensis 15 parts, Herba Silybi mariani 27 parts, Herba Pouzolziae Zeylanicae 23 parts, Herba Violae japonicae 16 parts, Fructus Leonuri 15 parts, Radix Cynanchi Paniculati 18 parts, Folium et cacumen Breyniae Fruticosae 16 parts, Herba lygodii 25 parts, Caulis et folium gaultheriae yunnanensis 16 parts, Radix Achyranthis 20 parts and Maifanitum 15 parts.

The present invention further provides again the preparation method of the chemotherapeutic phlebitic Chinese medicine preparation of a kind of above-mentioned treatment, and the dosage form of described Chinese medicine preparation is liniment, and its preparation method comprises the following steps:

Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 200 mesh sieves, the enable fine powder amount by 200 mesh sieves at least reaches 60%, collects and obtains fine powder a by the fine powder of 200 mesh sieves;

Step 2: the coarse powder not by 200 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds weight portion 8-10 times amount soak by water 1-3 hour, filters and obtains decocting liquid; Second time adds weight portion 6-10 times amount soak by water 1-3 hour, filters and obtains decocting liquid; Merge twice decocting liquid, filter to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;

Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.

The present invention further provides again the preparation method of the chemotherapeutic phlebitic Chinese medicine preparation of a kind of above-mentioned treatment, and the dosage form of described Chinese medicine preparation is capsule, and it comprises the following steps:

The first step, Herba galii veri, Flos Sophorae, Ambra Grisea, Herba Briggsiae Chienii, Herba Malvastri Coromandeliani, Herba Pteridis Multifidae and Lindernia angustifolia (Benth.) Wettst. are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 75 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;

Second step, Herba Aeschynonenes Indicae, Caulis aristolochiae moupinensis, Herba Silybi mariani, Herba Violae japonicae, Fructus Leonuri, Radix Cynanchi Paniculati and Herba lygodii are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 8 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1: liniment prepared by the present invention

Get Herba galii veri 130g, Flos Sophorae 200g, Ambra Grisea 250g, Herba Briggsiae Chienii 180g, Herba Malvastri Coromandeliani 180g, Herba Pteridis Multifidae 220g, Lindernia angustifolia (Benth.) Wettst. 180g, Herba Plantaginis 250g, Radix Helianthi 260g, Herba Aeschynonenes Indicae 180g, Caulis aristolochiae moupinensis 150g, Herba Silybi mariani 270g, Herba Pouzolziae Zeylanicae 230g, Herba Violae japonicae 160g, Fructus Leonuri 150g, Radix Cynanchi Paniculati 180g, Folium et cacumen Breyniae Fruticosae 160g, Herba lygodii 250g, Caulis et folium gaultheriae yunnanensis 160g, Radix Achyranthis 200g and Maifanitum 150g.

Its preparation method comprises the following steps:

Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 200 mesh sieves, the enable fine powder amount by 200 mesh sieves at least reaches 60%, collects and obtains fine powder a by the fine powder of 200 mesh sieves;

Step 2: the coarse powder not by 200 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds weight portion 9 times amount soak by water 3 hours, filters and obtains decocting liquid; Second time adds weight portion 7 times amount soak by water 2 hours, filters and obtains decocting liquid; Merge twice decocting liquid, filter to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;

Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.

Embodiment 2: capsule prepared by the present invention

Get Herba galii veri 110g, Flos Sophorae 230g, Ambra Grisea 210g, Herba Briggsiae Chienii 160g, Herba Malvastri Coromandeliani 150g, Herba Pteridis Multifidae 240g, Lindernia angustifolia (Benth.) Wettst. 160g, Herba Plantaginis 270g, Radix Helianthi 220g, Herba Aeschynonenes Indicae 160g, Caulis aristolochiae moupinensis 190g, Herba Silybi mariani 240g, Herba Pouzolziae Zeylanicae 210g, Herba Violae japonicae 190g, Fructus Leonuri 120g, Radix Cynanchi Paniculati 170g, Folium et cacumen Breyniae Fruticosae 180g, Herba lygodii 280g, Caulis et folium gaultheriae yunnanensis 180g, Radix Achyranthis 230g and Maifanitum 190g.

Its preparation method comprises the following steps:

The first step, Herba galii veri, Flos Sophorae, Ambra Grisea, Herba Briggsiae Chienii, Herba Malvastri Coromandeliani, Herba Pteridis Multifidae and Lindernia angustifolia (Benth.) Wettst. are mixed in described ratio, add the water extraction volatile oil relative to 5 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 4, stirs 80 minutes, temperature 40 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.16;

Second step, Herba Aeschynonenes Indicae, Caulis aristolochiae moupinensis, Herba Silybi mariani, Herba Violae japonicae, Fructus Leonuri, Radix Cynanchi Paniculati and Herba lygodii are mixed in described ratio, add relative to mixture 6 times amount determining alcohol be 85% alcohol reflux 4 times, each 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 9 times of water gagings, boil 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 65 DEG C of reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 6 weight portion carboxymethyl starch sodium, 30 weight starch mix homogeneously, adding 160 weight portion determining alcohols is 85% alcohol granulation, dry, granulate, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 4 weight portion magnesium stearate, then load in gelatine capsule.

Toxicity test:

Medicine for external use toxicity test:

1, experimental technique: depilatory is evenly coated by 4 groups of Cavia porcelluss (often organizing 15) spinal column both sides, back, makes unhairing scope about 40 square centimeters.Clean depilatory returns cage to observe 24 hours, wherein three groups, often organize Cavia porcellus and be coated with Chinese medicine preparation embodiment 1 liniment diluent 0.3,0.5 of the present invention and 0.8ml respectively, respectively containing crude drug 89mg, 148mg and 237mg, another group is coated with solvent 0.8ml, every twice-daily, continuous one week, after experiment terminates, Cavia porcellus is put to death, the heart, liver, kidney and depilation skin do pathological examination.

2, result: above-mentioned three groups of medication Cavia porcellus trunks depilation district, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group Cavia porcellus chroma of hair, ingest, matched group no significant difference, histopathologic examination, the medication group heart, liver, kidney and depilation skin and the matched group more also no significant difference such as extremity are movable.

Result is pointed out, and Chinese medicine for external application of the present invention, without local irritant effect, also has no general toxicity performance.Show Chinese medicine for external application use safety of the present invention.

Acute toxicity testing: application mice 60, male and female half and half, body weight 22-36g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine capsules prepared by embodiments of the invention 2, (concentration is 8.64g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 43.2 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage capsule LD50>43.2 crude drug/kg of the present invention, every day, maximum dosage-feeding was 86.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 8.52g crude drug/day/people, adult body weight in 60KG, average dosage is 0.142g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 29g) oral administration gavage Chinese medicine of the present invention is 608 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine embodiment 2 capsule of the present invention to three groups of mices (often organize 20) by 13.26,25.42 and 42.38g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: all 140 routine cases all derive from this Out-patient Department and inpatient, all because of intravenous applications chemotherapeutics, phlebitis occur.Man 83 example, female 57 example, age 34-77 year, wherein pulmonary carcinoma 36 example, gastric cancer 35 example, esophageal carcinoma 29 example, breast carcinoma 25 example, intestinal cancer 15 example.Be divided into treatment group and each 70 people of matched group at random, treatment group 70 people, man 43 example, female 27 example, age 34-77 year, wherein pulmonary carcinoma 18 example, gastric cancer 18 example, esophageal carcinoma 14 example, mammary cancer 12 example, intestinal cancer 8 example.Matched group 70 people, man 40 example, female 30 example, age 35-77 year, wherein pulmonary carcinoma 18 example, gastric cancer 17 example, esophageal carcinoma 15 example, mammary cancer 13 example, intestinal cancer 7 example.Treatment group and matched group be no significant difference (P > 0.05) on age and clinical symptoms, has comparability.

Diagnostic criteria: the diagnosis of chemotherapeutic phlebitis and classification are comparatively normal clinically at present, and what adopt is the standard of venous transfusion nurses association of the U.S.: 0 degree: transfusion part is without red, swollen, hot, bitterly and sense of discomfort.I grade: point of puncture local pain, red and swollen or edema, vein, without streak change, does not touch scleroma.II grade: point of puncture local pain, red and swollen or edema, vein has streak change, does not touch scleroma.III grade: point of puncture local pain, red and swollen or edema, vein has streak change, touches scleroma.

Therapeutic Method:

Treatment group: by the liniment uniform application of Chinese medicine embodiment 1 of the present invention in affected part, every 6-8h changes dressings 1 time.7 days courses for the treatment of.

Matched group: to be drenched by gauze with 33% Adlerika and directly spread on affected part afterwards, every 3-4h changes dressings 1 time, 7 days courses for the treatment of.

Meanwhile, vegetable and fruit diet and symptomatic treatment is kept two groups of every days.Treat and within first 1 week, stop using that all may affect the relevant medicine of test effect, and in therapeutic process, do not use medicine or the health product of other treatment chemotherapeutic phlebitis.

Curative effect judging standard: clinical cure: local skin is red, swollen, hot, pain transference cure, and the complete deliquescing of vein, changes without bar rope sample, and scleroma disappears.Effective: local skin is red, swollen, hot, pain transference cure, vein without scleroma, the deliquescing of bar rope sample red line, color reduction.Effective: localized heat, alleviation of pain are light, red, swollen area disappears >=and 60%, vein is without scleroma, and the deliquescing of bar rope sample red line, color does not go down.Invalid: disease is without improvement or improve less.

Therapeutic outcome: two groups treat 1 course for the treatment of respectively after, statistical result see table 1-1 and table 1-2.

Table 1-1 two groups treats Clinical efficacy comparison after 1 course for the treatment of (unit: example) respectively

Group	Number of cases	Cure	Effective	Effectively	Invalid	Total effective rate
							Treatment group	70	45	15	7	3	67(95.71％)
Matched group	70	24	19	12	15	55(78.57％)

As can be seen from table 1-1, adopt treatment by Chinese herbs chemotherapeutic phlebitis of the present invention, relative to matched group on therapeutic effect, there is significant improvement.

After table 1-2 two groups treats 1 course for the treatment of respectively, healing number and time compare (unit: example)

Group	Number of cases	Medication 2 days	Medication 4 days	Medication 7 days
					Treatment group	45	12(17.14％)	33(47.14％)	45(64.29％)
Matched group	24	5(7.14％)	14(20％)	24(34.29％)

As can be seen from table 1-2, adopt treatment by Chinese herbs chemotherapeutic phlebitis of the present invention, relative to matched group, treatment the course for the treatment of on significantly shorten; Simultaneously according to clinical observation, medicine of the present invention can eliminate the localized heat, bitterly of patient fast in 1-2 days, in 1-3 days fast elimination patient red, swell.

According to the clinical statistics in above table, Chinese medicine provided by the invention have rapid-action, effective percentage is high, the advantage of safe without toxic side effect.

Concrete case: Xu certain, man, 53 years old, there is phlebitis in after chemotherapy 2 days in the intravenous chemotherapy because suffering from pulmonary carcinoma, and according to point of puncture local pain, red and swollen or edema, vein has streak change, touches scleroma, is diagnosed as III chemotherapeutic phlebitis of 2 level and 3.Through smearing the liniment of the embodiment of the present invention 1, within every 6 hours, smear once, treat that the 2nd afternoon local skin is red, swollen, hot, pain symptom is just basic disappears, after 5 days local skin red, swollen, hot, pain transference cure, the complete deliquescing of vein, changes without bar rope sample, and scleroma disappears, clinical cure, follows up a case by regular visits to 1 month without recurrence.

All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (8)

1. the chemotherapeutic phlebitic Chinese medicine preparation for the treatment of, it is characterized in that, described Chinese medicine preparation comprises following raw medicinal material: Herba galii veri, Flos Sophorae, Ambra Grisea, Herba Briggsiae Chienii, Herba Malvastri Coromandeliani, Herba Pteridis Multifidae, Lindernia angustifolia (Benth.) Wettst., Herba Plantaginis, Radix Helianthi, Herba Aeschynonenes Indicae, Caulis aristolochiae moupinensis, Herba Silybi mariani, Herba Pouzolziae Zeylanicae, Herba Violae japonicae, Fructus Leonuri, Radix Cynanchi Paniculati, Folium et cacumen Breyniae Fruticosae, Herba lygodii, Caulis et folium gaultheriae yunnanensis, Radix Achyranthis and Maifanitum.

2. Chinese medicine preparation as claimed in claim 1, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba galii veri 10 ~ 20 parts, 10 ~ 25 parts, Flos Sophorae, Ambra Grisea 10 ~ 30 parts, Herba Briggsiae Chienii 15 ~ 25 parts, Herba Malvastri Coromandeliani 10 ~ 25 parts, Herba Pteridis Multifidae 15 ~ 25 parts, Lindernia angustifolia (Benth.) Wettst. 10 ~ 25 parts, Herba Plantaginis 10 ~ 30 parts, Radix Helianthi 15 ~ 30 parts, Herba Aeschynonenes Indicae 10 ~ 25 parts, Caulis aristolochiae moupinensis 10 ~ 20 parts, Herba Silybi mariani 20 ~ 35 parts, Herba Pouzolziae Zeylanicae 20 ~ 30 parts, Herba Violae japonicae 10 ~ 20 parts, Fructus Leonuri 10 ~ 25 parts, Radix Cynanchi Paniculati 15 ~ 25 parts, Folium et cacumen Breyniae Fruticosae 10 ~ 20 parts, Herba lygodii 15 ~ 30 parts, Caulis et folium gaultheriae yunnanensis 10 ~ 20 parts, Radix Achyranthis 10 ~ 25 parts and Maifanitum 10 ~ 20 parts.

3. Chinese medicine preparation as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba galii veri 10 ~ 15 parts, 15 ~ 25 parts, Flos Sophorae, Ambra Grisea 20 ~ 30 parts, Herba Briggsiae Chienii 15 ~ 20 parts, Herba Malvastri Coromandeliani 15 ~ 20 parts, Herba Pteridis Multifidae 20 ~ 25 parts, Lindernia angustifolia (Benth.) Wettst. 15 ~ 20 parts, Herba Plantaginis 20 ~ 30 parts, Radix Helianthi 20 ~ 30 parts, Herba Aeschynonenes Indicae 15 ~ 20 parts, Caulis aristolochiae moupinensis 15 ~ 20 parts, Herba Silybi mariani 20 ~ 30 parts, Herba Pouzolziae Zeylanicae 20 ~ 25 parts, Herba Violae japonicae 15 ~ 20 parts, Fructus Leonuri 10 ~ 20 parts, Radix Cynanchi Paniculati 15 ~ 20 parts, Folium et cacumen Breyniae Fruticosae 15 ~ 20 parts, Herba lygodii 20 ~ 30 parts, Caulis et folium gaultheriae yunnanensis 15 ~ 20 parts, Radix Achyranthis 15 ~ 25 parts and Maifanitum 15 ~ 20 parts.

4. the Chinese medicine preparation as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba galii veri 13 parts, 20 parts, Flos Sophorae, Ambra Grisea 25 parts, Herba Briggsiae Chienii 18 parts, Herba Malvastri Coromandeliani 18 parts, Herba Pteridis Multifidae 22 parts, Lindernia angustifolia (Benth.) Wettst. 18 parts, Herba Plantaginis 25 parts, Radix Helianthi 26 parts, Herba Aeschynonenes Indicae 18 parts, Caulis aristolochiae moupinensis 15 parts, Herba Silybi mariani 27 parts, Herba Pouzolziae Zeylanicae 23 parts, Herba Violae japonicae 16 parts, Fructus Leonuri 15 parts, Radix Cynanchi Paniculati 18 parts, Folium et cacumen Breyniae Fruticosae 16 parts, Herba lygodii 25 parts, Caulis et folium gaultheriae yunnanensis 16 parts, Radix Achyranthis 20 parts and Maifanitum 15 parts.

5. the Chinese medicine preparation as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is liniment, and its preparation method comprises the following steps:

Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 200 mesh sieves, the enable fine powder amount by 200 mesh sieves at least reaches 60%, collects and obtains fine powder a by the fine powder of 200 mesh sieves;

Step 2: the coarse powder not by 200 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds weight portion 8-10 times amount soak by water 1-3 hour, filters and obtains decocting liquid; Second time adds weight portion 6-10 times amount soak by water 1-3 hour, filters and obtains decocting liquid; Merge twice decocting liquid, filter to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;

Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.

6. the Chinese medicine preparation as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is capsule, and its preparation method comprises the following steps:

The first step, Herba galii veri, Flos Sophorae, Ambra Grisea, Herba Briggsiae Chienii, Herba Malvastri Coromandeliani, Herba Pteridis Multifidae and Lindernia angustifolia (Benth.) Wettst. are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 75 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;

Second step, Herba Aeschynonenes Indicae, Caulis aristolochiae moupinensis, Herba Silybi mariani, Herba Violae japonicae, Fructus Leonuri, Radix Cynanchi Paniculati and Herba lygodii are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 8 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.

7. a preparation method for the Chinese medicine preparation described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is liniment, and its preparation method comprises the following steps:

Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 200 mesh sieves, the enable fine powder amount by 200 mesh sieves at least reaches 60%, collects and obtains fine powder a by the fine powder of 200 mesh sieves;

Step 2: the coarse powder not by 200 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds weight portion 8-10 times amount soak by water 1-3 hour, filters and obtains decocting liquid; Second time adds weight portion 6-10 times amount soak by water 1-3 hour, filters and obtains decocting liquid; Merge twice decocting liquid, filter to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;

Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.

8. a preparation method for the Chinese medicine preparation described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is capsule, and its preparation method comprises the following steps:

The first step, Herba galii veri, Flos Sophorae, Ambra Grisea, Herba Briggsiae Chienii, Herba Malvastri Coromandeliani, Herba Pteridis Multifidae and Lindernia angustifolia (Benth.) Wettst. are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 75 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;

Second step, Herba Aeschynonenes Indicae, Caulis aristolochiae moupinensis, Herba Silybi mariani, Herba Violae japonicae, Fructus Leonuri, Radix Cynanchi Paniculati and Herba lygodii are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 8 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.