CN105456794A - Traditional Chinese medicine for treating chemotherapeutic phlebitis of tumor patient and preparation method thereof - Google Patents

Traditional Chinese medicine for treating chemotherapeutic phlebitis of tumor patient and preparation method thereof Download PDF

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CN105456794A
CN105456794A CN201511025810.3A CN201511025810A CN105456794A CN 105456794 A CN105456794 A CN 105456794A CN 201511025810 A CN201511025810 A CN 201511025810A CN 105456794 A CN105456794 A CN 105456794A
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herba
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张云
李亮
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention provides a traditional Chinese medicine for treating chemotherapeutic phlebitis of a tumor patient and a preparation method thereof. The traditional Chinese medicine is prepared from hairyvein agrimonia herb and bud, wood of Chinese redbud, fissistigma bracteolatum, tephroseris kirilowii, semen lepidii, vitis bryoniifolia roots, petasites japonicus, leaves of Japanese bananas, splendid achnatherum, calligonum mongolicum fruits, pondweeds, herbofIndian pentanema, triquetrous tadehagi herb, scytosiphon lomentarius, herb of jamaica falsevalerian and fragrant marshweed herb. The traditional Chinese medicine has the advantages that the traditional Chinese medicine used for chemotherapeutic phlebitis is convenient to use, safe, free of toxic and side effects and anaphylactic reactions, high in effective rate, fast in effect taking and simple in preparation process.

Description

One treats phlebitic Chinese medicine of Chemotherapy of Tumor Patients and preparation method thereof
Technical field
The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to one and treat phlebitic Chinese medicine of Chemotherapy of Tumor Patients and preparation method thereof.
Background technology
Intravenous chemotherapy is one of important means for the treatment of malignant tumor at present.Because most of chemotherapeutics is chemistry or alkaloid formulations, toxicity is large, concentration is high, repeatedly, repeatedly, Large Dose Intravenous impacts the mechanical stimulus that causes of chemotherapy and the intense stimulus of high concentration medicine to local can cause administration vein and adjacent tissue is rubescent, swelling, pain, sclerosis of blood vessels etc., cause phlebitis.Phlebitis in various degree can be there is in the patients undergoing chemotherapy of 50%-80%.Chemotherapeutic phlebitis is one common in phlebitis, is one of toxicity of chemotherapeutic period, and it is because the toxicity of chemotherapeutics stimulates, and makes caused by vascular endothelial injury.Once generation phlebitis, not only cause suffering to patient, increase the work difficulty of medical personnel, increase medical expense, severe patient can affect carrying out smoothly of the chemotherapy cycles of patient, even makes limbs of patient function impaired.
The common main triggering factors of chemotherapeutic phlebitis has: 1, mechanical injuries: infusion process Zhong Wei strict implement sterile working, vein repeatedly penetration damage blood vessel endothelium or venous detaining needle retention time is long causes vein mechanical damage.Tumour patient repeatedly chemotherapy in a short time, carries out the blood vessel of chemotherapy by broken ring in addition, and venipuncture difficulty increases.If venipuncture one-time success rate is low or fixed needle position is improper also can increase mechanical injuries.2, chemotherapeutics damages the zest of vein: due to chronic infusion high concentration, chemotherapeutics that zest is stronger, and especially corrosivity chemotherapeutics injects peripheral vein, causes tunica intima of vein chemical injury in various degree.3, the hypercoagulability of malignant tumor patient: the malignant tumor patient of more than 50% and 90%, with the malignant tumor patient shifted, all exists the exception of one or more coagulation indexes.Because tumor h substance activates blood coagulation system clotting mechanism extremely directly or indirectly, chemotherapeutics can cause again tissue factor to discharge simultaneously, and fibrinolytic is suppressed, and the toxic action of medicine has increased the weight of tumor patient phlebitis and formed.
Therapeutic Method conventional at present has cold compress, drug blockage, local physical therapy, topical remedy's soak or external application etc., though there is certain therapeutical effect, curative effect is still not ideal.
The traditional Chinese medical science thinks that phlebitic mechanism is qi depression to blood stasis, and poison knot stagnates in blood vessels, causes local venation QI-blood circulation not smooth.Freely then do not become silted up, the stagnant resistance of congestion, stagnation of QI and blood may bring about pain; QI and blood is smooth, and the defeated cloth of body fluid is obstructed then swelling; Accumulate in blood stasis, accumulate heat-transformation of a specified duration, then local pyrexia; Venation is damaged, and it is rubescent blue to accumulate then local in blood oozing from the body openings or subcuta neous tissue skin or heat in blood.
Summary of the invention
Technical problem to be solved by this invention is, utilizes the theory of Chinese medical science that China is traditional, provides a kind of novel use safety, has no side effect, the phlebitic Chinese medicine for the treatment of Chemotherapy of Tumor Patients that effective percentage is high and preparation method thereof.
In order to solve the problems of the technologies described above, the invention provides one and treat the phlebitic Chinese medicine of Chemotherapy of Tumor Patients, described Chinese medicine comprises following raw medicinal material: Herba Agrimoniae, Lignum cercis chinensis, Cortex Fissistigmatis bracteolati Radicis, Herba Senecionis Kirilowi, Semen Lepidii (Semen Descurainiae), Radix vitis thunbergii (Radix Vitis Adstrictae), Petasites japonicus, Folium Musae, Caulis Achnatheri Splendentis, Radix Calligoni Mongolici, Herba potamogetonis distincti, Herba Pentanematis Indici, Herba Desmodii Triquetri (Herba Tadehagi Triquetri), Scytosiphon lomentarius (Lyngh.)J. Ag., Herba Stachytarphetae Jamaicensis and Herba Limnophilae Aromaticae.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably: Herba Agrimoniae 10 ~ 20 parts, Lignum cercis chinensis 15 ~ 25 parts, Cortex Fissistigmatis bracteolati Radicis 20 ~ 30 parts, Herba Senecionis Kirilowi 10 ~ 20 parts, Semen Lepidii (Semen Descurainiae) 15 ~ 25 parts, Radix vitis thunbergii (Radix Vitis Adstrictae) 10 ~ 20 parts, Petasites japonicus 20 ~ 30 parts, Folium Musae 10 ~ 20 parts, Caulis Achnatheri Splendentis 10 ~ 20 parts, Radix Calligoni Mongolici 5 ~ 15 parts, Herba potamogetonis distincti 20 ~ 30 parts, Herba Pentanematis Indici 10 ~ 20 parts, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 15 ~ 25 parts, Scytosiphon lomentarius (Lyngh.)J. Ag. 10 ~ 20 parts, Herba Stachytarphetae Jamaicensis 15 ~ 25 parts and Herba Limnophilae Aromaticae 20 ~ 30 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also more preferably: Herba Agrimoniae 15 ~ 20 parts, Lignum cercis chinensis 17 ~ 22 parts, Cortex Fissistigmatis bracteolati Radicis 25 ~ 30 parts, Herba Senecionis Kirilowi 12 ~ 17 parts, Semen Lepidii (Semen Descurainiae) 18 ~ 23 parts, Radix vitis thunbergii (Radix Vitis Adstrictae) 10 ~ 15 parts, Petasites japonicus 23 ~ 28 parts, Folium Musae 12 ~ 17 parts, Caulis Achnatheri Splendentis 10 ~ 15 parts, Radix Calligoni Mongolici 8 ~ 13 parts, Herba potamogetonis distincti 22 ~ 27 parts, Herba Pentanematis Indici 13 ~ 18 parts, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 17 ~ 22 parts, Scytosiphon lomentarius (Lyngh.)J. Ag. 10 ~ 15 parts, Herba Stachytarphetae Jamaicensis 15 ~ 20 parts and Herba Limnophilae Aromaticae 20 ~ 25 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine also can more preferably: Herba Agrimoniae 18 parts, Lignum cercis chinensis 19 parts, Cortex Fissistigmatis bracteolati Radicis 28 parts, Herba Senecionis Kirilowi 14 parts, Semen Lepidii (Semen Descurainiae) 22 Fen, Radix vitis thunbergii (Radix Vitis Adstrictae) 10 parts, Petasites japonicus 26 parts, Folium Musae 12 parts, Caulis Achnatheri Splendentis 15 parts, Radix Calligoni Mongolici 8 parts, Herba potamogetonis distincti 26 parts, Herba Pentanematis Indici 14 parts, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 22 parts, Scytosiphon lomentarius (Lyngh.)J. Ag. 12 parts, Herba Stachytarphetae Jamaicensis 18 parts and Herba Limnophilae Aromaticae 20 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine also can more preferably: Herba Agrimoniae 15 parts, Lignum cercis chinensis 22 parts, Cortex Fissistigmatis bracteolati Radicis 25 parts, Herba Senecionis Kirilowi 16 parts, Semen Lepidii (Semen Descurainiae) 18 Fen, Radix vitis thunbergii (Radix Vitis Adstrictae) 14 parts, Petasites japonicus 24 parts, Folium Musae 15 parts, Caulis Achnatheri Splendentis 12 parts, Radix Calligoni Mongolici 12 parts, Herba potamogetonis distincti 22 parts, Herba Pentanematis Indici 16 parts, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 18 parts, Scytosiphon lomentarius (Lyngh.)J. Ag. 15 parts, Herba Stachytarphetae Jamaicensis 15 parts and Herba Limnophilae Aromaticae 24 parts.
When the dosage form of described Chinese medicine is unguentum, its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, decocts with water 2 ~ 4 times, each 2 ~ 5 hours, add the water of 6 ~ 10 times amount, decoction liquor is filtered at every turn, merge the filtrate of each time, add determining alcohol be 90% ~ 95% ethanol to alcohol content be 50% ~ 60%, leave standstill 3 ~ 5 hours, filter, filtrate concentrates, and drying is also pulverized, and obtains mixed-powder, cross 200 mesh sieves, adopt ultra violet lamp sterilizing in 1 ~ 2 hour;
Second step, relative to mixed-powder described in 100 weight portions that the first step obtains, 1 weight portion ~ 3 weight portion stearic acid, 0.5 weight portion ~ 1.5 weight portion stearyl alcohol, 0.5 weight portion ~ 1.5 weight portion glyceryl monostearate, 3 weight portion ~ 5 weight portion liquid Paraffin, 8 weight portion ~ 10 weight portion dimethicones are mixed and heated to 75 DEG C ~ 85 DEG C, under constantly stirring, add 1 weight portion ~ 3 part by weight of vitamin E dissolve, obtain oil phase;
3rd step, relative to mixed-powder described in 100 weight portions that the first step obtains, 0.5 weight portion ~ 1.5 weight portion sodium lauryl sulphate, 0.5 weight portion ~ 1.5 weight portion triethanolamine, 1 weight portion ~ 2 weight portion ethyl hydroxybenzoate, 1000 weight portion ~ 1500 weight portion distilled water are mixed and heated to 75 DEG C ~ 85 DEG C, obtain aqueous phase;
4th step, the oil phase obtained by second step slowly adds in the aqueous phase of the 3rd step acquisition under constantly stirring, and fully stirs 50 ~ 90 minutes, makes emulsifying, add the mixed-powder that the first step obtains, stir, subpackage at the temperature of 60 DEG C ~ 70 DEG C.
When the dosage form of described Chinese medicine is oral solutions, its preparation method comprises the following steps:
The first step, by Herba Agrimoniae, Lignum cercis chinensis, Cortex Fissistigmatis bracteolati Radicis, Herba Senecionis Kirilowi, Semen Lepidii (Semen Descurainiae), Radix vitis thunbergii (Radix Vitis Adstrictae), Petasites japonicus, Folium Musae, Caulis Achnatheri Splendentis and Radix Calligoni Mongolici mixing, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;
3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours, and refrigerated storage temperature is 2 DEG C ~ 6 DEG C;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine oral liquid finished product.
Beneficial effect of the present invention: the Chinese medicine that chemotherapeutic phlebitis of the present invention uses is easy to use, and safe without toxic side effect, without anaphylaxis, effective percentage is high, instant effect, and preparation technology is simple.
Detailed description of the invention
The invention provides one and treat the phlebitic Chinese medicine of Chemotherapy of Tumor Patients, Chinese medicine comprises following raw medicinal material: Herba Agrimoniae, Lignum cercis chinensis, Cortex Fissistigmatis bracteolati Radicis, Herba Senecionis Kirilowi, Semen Lepidii (Semen Descurainiae), Radix vitis thunbergii (Radix Vitis Adstrictae), Petasites japonicus, Folium Musae, Caulis Achnatheri Splendentis, Radix Calligoni Mongolici, Herba potamogetonis distincti, Herba Pentanematis Indici, Herba Desmodii Triquetri (Herba Tadehagi Triquetri), Scytosiphon lomentarius (Lyngh.)J. Ag., Herba Stachytarphetae Jamaicensis and Herba Limnophilae Aromaticae and Herba Limnophilae Aromaticae.
The pharmacology of various raw medicinal material is as follows:
Herba Agrimoniae: [another name] Bud of hairyvein agrimony, Radix Agrimoniae, execute state Radix Agrimoniae, melon Rhizoma et radix valerianae, HUANGLONG tail, ferrum wasp, goldentop dragon bud, old stork mouth, primary and secondary grass, dry foot mattress, HUANGLONG tooth, grass fossilia dentis mastodi, Herba Thymi, Herba Malvastri Coromandeliani, Serpentis pimple, tap grass, very little eight joints, Lysimachia christinae Hance, dry foot chicken, Jerry flower, line MAZIHUA, Herba silenes fortunei, Folium Ainslaea Triflorae, Herba Blumeae Balsamiferae, ground Herba mesonae chinensis, Herba Lespedezae Cuneatae, roadside chicken, radix euphorbiae, chicken feet is husky, LUBIANHUANG, five hoof wind, ox head grass, dysentery grass, Folium seu radix sidae mysorensis, different wind neck grass, son is not from mother, father and son's grass, hair chicken grass, group orchid relieves internal heat grass, Indigofera pseudotinctoria, Folium Callicarpae Formosanae HUANGLONG tooth.[source] medical material Ji Yuan: be the aerial parts of rosaceous plant Agrimony.[nature and flavor] bitter in the mouth, puckery, property is put down.[return through] lung; Liver; Spleen channel.[function cures mainly] astringing to arrest bleeding, dysentery relieving, parasite killing.Main spitting of blood; Spit blood; Hematuria; Have blood in stool; Dysentery; Bleeding not during menses; Impairment caused by overstrain takes off power; Carbuncle; Traumatic injury; Wound hemorrhage.[extracts] " China's book on Chinese herbal medicine "
Lignum cercis chinensis: [source] medical material Ji Yuan: be the woody part of leguminous plant cercis.[nature and flavor] are bitter; Flat; Nontoxic.[return through] liver; Kidney channel.[function cures mainly] invigorates blood circulation; Treating stranguria.Main menoxenia, the stagnant stomachache of the stasis of blood, the puckery pain of dribbling urination.[extracts] " China's book on Chinese herbal medicine "
Cortex Fissistigmatis bracteolati Radicis: [another name] GUANGXIANG rattan, MANSHANXIANG.[source] medical material Ji Yuan: be the root bark of the how luxuriant Radix Fissistigmatis Oldhamii of annonaceae plant.[nature and flavor] are pungent puckery; Temperature.[return through] liver; Spleen channel.[function cures mainly] promoting blood circulation and hemostasis.Main traumatic hemorrhage; Fracture; Traumatic injury.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "
Herba Senecionis Kirilowi: [another name] Canis familiaris L. tongue grass, white erysipelas grass, Herba Senecionis Kirilowi (Herba Tripterospermi), Oryza glutinosa green grass or young crops, copper dish Herba Veronicae, nine leaf grass, damp dolly.[source] medical material Ji Yuan: be the herb of feverfew Herba Senecionis Kirilowi.[nature and flavor] bitter in the mouth; Cold in nature.[function cures mainly] heat-clearing and toxic substances removing; Inducing diuresis to remove edema; Parasite killing.Main swollen pus infections furuncle and phyma; Urinary tract infection; Oedema due to nephritis; Stomatitis; Traumatic injury; Eczema; Scabies; Trichomonas vaginitis.[extracts] " China's book on Chinese herbal medicine "
Semen Lepidii (Semen Descurainiae): [another name] fourth is gone through, suitable greatly, large room.[source] medical material Ji Yuan: be the seed of crucifer Semen Lepidii, qin leaf Semen Lepidii and descurainia sophia (l.) webb ex prantl.[nature and flavor] are pungent; Bitter; Cold.[return through] lung; The heart; Liver; Stomach; Urinary bladder channel.[function cures mainly] eliminating the pathogens from the lung sending down the abnormal ascending QI; Eliminating phlegm and relieving asthma; Inducing diuresis to remove edema; Let out by heresy.Main sputum stops up the dyspnea and cough with excessive sputum of lung; Lung abscess; Edema; Breast abdomen hydrops; Dysuria; Chronic pulmonary heart disease; Breathing heavily of heart failure is swollen; Scrofula tuberculosis.[extracts] " China's book on Chinese herbal medicine "
Radix vitis thunbergii (Radix Vitis Adstrictae): [another name] Radix vitis romanetii.[source] medical material Ji Yuan: for the root of thing Caulis et folium vitis thunbergii is planted by grape section of Portugal.[nature and flavor] are sweet; Flat.[return through] liver; Spleen channel.[function cures mainly] clearing away heat-damp and promoting diuresis; Removing toxic substances and promoting subsidence of swelling.Main damp and hot; Jaundice; Pyretic stranguria; Dysentery; Carbuncle pyogenic infections from tumour or sore; Scrofula; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "
Petasites japonicus: [another name] Rhizoma petasitis japonici, water clock stream head, black Fructus Cucurbitae moschatae, wild meal melon, Fructus Cucurbitae moschatae Radix Notoginseng, calabazilla, wild golden melon head, Petasites officinalis Moench, twine skin.[source] medical material Ji Yuan: be rhizome and the herb of feverfew Petasites japonicus.[nature and flavor] bitter in the mouth; Pungent; Cool in nature.[function cures mainly] heat-clearing and toxic substances removing; Dissipating blood stasis for subsidence of swelling.Main laryngopharynx swelling and pain; Carbuncle furunculosis; Venom; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "
Folium Musae: [source] medical material Ji Yuan: be the leaf of Musaceae plant Musa basjoo Sieb. Et Zucc..[nature and flavor] sweet in the mouth; Light; Cold in nature.[return through] heart; Liver Channel.[function cures mainly] heat clearing away; Diuresis; Removing toxic substances.Main calentura; Heatstroke; Edema; Foot gas; Carbuncle; Scald.[extracts] " China's book on Chinese herbal medicine "
Caulis Achnatheri Splendentis: [another name] trifoliate orange splendid achnatherum grass, splendid achnatherum, seat dustpan grass.[source] medical material Ji Yuan: be the stem of grass Caulis Achnatheri Splendentis, root or seed.[nature and flavor] are sweet; Light; Flat.[function cures mainly] clearing away heat and promoting diuresis.Main urinary tract infection; Urine retention.[extracts] " China's book on Chinese herbal medicine "
Radix Calligoni Mongolici: [another name] hair grass.[source] medical material Ji Yuan: be root or the band fruit herb of polygonaceae plant Radix Calligoni Mongolici.[nature and flavor] are bitter; Puckery; Slightly warm in nature.[function cures mainly] heat-clearing and toxic substances removing; Diuresis.Main pyretic stranguria; Turbid urine; Furuncle treats poison; Chapped skin.[extracts] " China's book on Chinese herbal medicine "
Herba potamogetonis distincti: [another name] tooth grass, tooth pick up grass, Herba Potamogetonis Natantis, golden comb grass, water stool, bundle plank, bullet wood leaf, chopping board bud, RadixThalictrisimplicis, sandalwood leaf, lubricating oil pellet.[source] medical material Ji Yuan: be the herb of Potamogetonaceae plant Herba potamogetonis distincti and cockscomb Herba potamogetonis distincti.[nature and flavor] bitter in the mouth; Cold in nature.[return through] gallbladder; Liver; Urinary bladder channel.[function cures mainly] heat-clearing and toxic substances removing; Dampness removing is treating stranguria; Hemostasis; Drive ascarid.Main hygropyretic dysentery; Jaundice; Pyretic stranguria; Leukorrhagia; Epistaxis; Bleeding hemorrhoids; Ascariasis; Sore and toxic.[extracts] " China's book on Chinese herbal medicine "
Herba Pentanematis Indici: [another name] steps on sub-tight, seven wind syndrome of head, rough leaf Herba Violae, Herba Pentanematis Indici, wild China fir root.[source] medical material Ji Yuan: for feverfew carries on the back the herb of reed millet straw in vain.[nature and flavor] are lightly seasoned; Cool in nature.[function cures mainly] heat-clearing and toxic substances removing; Relieving stranguria by diuresis.Main Zha rib; Laryngopharynx swelling and pain; Stranguria caused by urinary stone.[extracts] " China's book on Chinese herbal medicine "
Herba Desmodii Triquetri (Herba Tadehagi Triquetri): [another name] cattle Cordyceps, compel neck grass, hundred labor tongues, Anisomeles indica (L.) Kuntze, Herba Desmodii Triquetri (Herba Tadehagi Triquetri), field handle of a knife, encourage plate tea, cured fish grass, fiber crops grass, Manitis tongue, Rhizoma Solani tuber osi, Ma Zhuan, imperial tongue Huang, Trionyx sinensis Wiegmann neck grass, Flos Wikstroemiae Nutantis, Desmodiumtrilorumrr., imperial tongue extensively, calabash leaf.[source] medical material Ji Yuan: be the branch and leaf of leguminous plant Herba Desmodii Triquetri (Herba Tadehagi Triquetri), viticula Herba Desmodii Triquetri (Herba Tadehagi Triquetri).[nature and flavor] bitter in the mouth; Puckery; Cool in nature.[return through] lung; Liver; Urinary bladder channel.[function cures mainly] heat-clearing and toxic substances removing; Dampness removing jaundice eliminating; Eliminating stagnated food and killing intestinal worms.Main heatstroke excessive thirst; Cold, fever; Laryngopharynx swelling and pain; Pain in the lung hemoptysis; Nephritis; Jaundice; Have loose bowels; Dysentery; Rheumatic arthritis; Infantile malnutrition; Ancylostomiasis; Scabies.[extracts] " China's book on Chinese herbal medicine "
Scytosiphon lomentarius (Lyngh.)J. Ag.: [another name] extra large linen thread, extra large loud, high-pitched sound, drag for sub-muscle, Huanghai Sea dish, Ottelia acuminata (Gagnep.) Dandy pipe, Cacumen et folium clerodendri mandarinori (Clerodendron mandarinorum Diels) grass.[source] medical material Ji Yuan: be the frond of Scytosiphonales plant Scytosiphon lomentarius (Lyngh.)J. Ag..[nature and flavor] are salty; Cold.[return through] enters liver, lung meridian.[function cures mainly] resolving phlegm and softening hard masses; Heat-clearing and toxic substances removing.Main cough; Laryngitis; Goiter; Lymphonodi cervicales swells.[extracts] " China's book on Chinese herbal medicine "
Herba Stachytarphetae Jamaicensis: [another name] beautiful youth whip, large Herba Chlorophyti, omnipotent grass.[source] medical material Ji Yuan: be herb and the root of the false horsewhip of Verbenaceae.[nature and flavor] sweet in the mouth; Micro-hardship; Cold in nature.[return through] heart; Liver; Kidney channel.[function cures mainly] clearing away heat-damp and promoting diuresis; Removing toxic substances and promoting subsidence of swelling.Main pyretic stranguria; Stranguria caused by urinary stone; Nebulousurine; Leucorrhea; Rheumatic ostalgia; Acute conjunctivitis; Pharyngolaryngitis; Gingivitis; Cholecystitis; Carbuncle furuncle; Hemorrhoid; Treating swelling and pain by traumatic injury.[extracts] " China's book on Chinese herbal medicine "
Herba Limnophilae Aromaticae: [another name] water mint, cartilage Thalictrum omeiense W. T. Wang et S. H. Wang, water pipe cylinder, trident grass, water pipe is careless, clearance is careless, disappear at once, Passeris montani saturati grass, disappear under horse, cough-relieving grass.[source] medical material Ji Yuan: be the herb of goatweed Limnophila aromatica.[nature and flavor] acrid in the mouth; Cool in nature.[function cures mainly] clearing away lung-heat to relieve cough; Subduing swelling and detoxicating.Main cold cough; Pertussis; Venom; Sore and toxic; Tinea scabies; Skin pruritus.[extracts] " China's book on Chinese herbal medicine "
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably: Herba Agrimoniae 10 ~ 20 parts, Lignum cercis chinensis 15 ~ 25 parts, Cortex Fissistigmatis bracteolati Radicis 20 ~ 30 parts, Herba Senecionis Kirilowi 10 ~ 20 parts, Semen Lepidii (Semen Descurainiae) 15 ~ 25 parts, Radix vitis thunbergii (Radix Vitis Adstrictae) 10 ~ 20 parts, Petasites japonicus 20 ~ 30 parts, Folium Musae 10 ~ 20 parts, Caulis Achnatheri Splendentis 10 ~ 20 parts, Radix Calligoni Mongolici 5 ~ 15 parts, Herba potamogetonis distincti 20 ~ 30 parts, Herba Pentanematis Indici 10 ~ 20 parts, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 15 ~ 25 parts, Scytosiphon lomentarius (Lyngh.)J. Ag. 10 ~ 20 parts, Herba Stachytarphetae Jamaicensis 15 ~ 25 parts and Herba Limnophilae Aromaticae 20 ~ 30 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also more preferably: Herba Agrimoniae 15 ~ 20 parts, Lignum cercis chinensis 17 ~ 22 parts, Cortex Fissistigmatis bracteolati Radicis 25 ~ 30 parts, Herba Senecionis Kirilowi 12 ~ 17 parts, Semen Lepidii (Semen Descurainiae) 18 ~ 23 parts, Radix vitis thunbergii (Radix Vitis Adstrictae) 10 ~ 15 parts, Petasites japonicus 23 ~ 28 parts, Folium Musae 12 ~ 17 parts, Caulis Achnatheri Splendentis 10 ~ 15 parts, Radix Calligoni Mongolici 8 ~ 13 parts, Herba potamogetonis distincti 22 ~ 27 parts, Herba Pentanematis Indici 13 ~ 18 parts, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 17 ~ 22 parts, Scytosiphon lomentarius (Lyngh.)J. Ag. 10 ~ 15 parts, Herba Stachytarphetae Jamaicensis 15 ~ 20 parts and Herba Limnophilae Aromaticae 20 ~ 25 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine also can more preferably: Herba Agrimoniae 18 parts, Lignum cercis chinensis 19 parts, Cortex Fissistigmatis bracteolati Radicis 28 parts, Herba Senecionis Kirilowi 14 parts, Semen Lepidii (Semen Descurainiae) 22 Fen, Radix vitis thunbergii (Radix Vitis Adstrictae) 10 parts, Petasites japonicus 26 parts, Folium Musae 12 parts, Caulis Achnatheri Splendentis 15 parts, Radix Calligoni Mongolici 8 parts, Herba potamogetonis distincti 26 parts, Herba Pentanematis Indici 14 parts, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 22 parts, Scytosiphon lomentarius (Lyngh.)J. Ag. 12 parts, Herba Stachytarphetae Jamaicensis 18 parts and Herba Limnophilae Aromaticae 20 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine also can more preferably: Herba Agrimoniae 15 parts, Lignum cercis chinensis 22 parts, Cortex Fissistigmatis bracteolati Radicis 25 parts, Herba Senecionis Kirilowi 16 parts, Semen Lepidii (Semen Descurainiae) 18 Fen, Radix vitis thunbergii (Radix Vitis Adstrictae) 14 parts, Petasites japonicus 24 parts, Folium Musae 15 parts, Caulis Achnatheri Splendentis 12 parts, Radix Calligoni Mongolici 12 parts, Herba potamogetonis distincti 22 parts, Herba Pentanematis Indici 16 parts, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 18 parts, Scytosiphon lomentarius (Lyngh.)J. Ag. 15 parts, Herba Stachytarphetae Jamaicensis 15 parts and Herba Limnophilae Aromaticae 24 parts.
The present invention further provides again the preparation method of the phlebitic Chinese medicine of a kind of above-mentioned treatment Chemotherapy of Tumor Patients, and when the dosage form of described Chinese medicine is unguentum, its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, decocts with water 2 ~ 4 times, each 2 ~ 5 hours, add the water of 6 ~ 10 times amount, decoction liquor is filtered at every turn, merge the filtrate of each time, add determining alcohol be 90% ~ 95% ethanol to alcohol content be 50% ~ 60%, leave standstill 3 ~ 5 hours, filter, filtrate concentrates, and drying is also pulverized, and obtains mixed-powder, cross 200 mesh sieves, adopt ultra violet lamp sterilizing in 1 ~ 2 hour;
Second step, relative to mixed-powder described in 100 weight portions that the first step obtains, 1 weight portion ~ 3 weight portion stearic acid, 0.5 weight portion ~ 1.5 weight portion stearyl alcohol, 0.5 weight portion ~ 1.5 weight portion glyceryl monostearate, 3 weight portion ~ 5 weight portion liquid Paraffin, 8 weight portion ~ 10 weight portion dimethicones are mixed and heated to 75 DEG C ~ 85 DEG C, under constantly stirring, add 1 weight portion ~ 3 part by weight of vitamin E dissolve, obtain oil phase;
3rd step, relative to mixed-powder described in 100 weight portions that the first step obtains, 0.5 weight portion ~ 1.5 weight portion sodium lauryl sulphate, 0.5 weight portion ~ 1.5 weight portion triethanolamine, 1 weight portion ~ 2 weight portion ethyl hydroxybenzoate, 1000 weight portion ~ 1500 weight portion distilled water are mixed and heated to 75 DEG C ~ 85 DEG C, obtain aqueous phase;
4th step, the oil phase obtained by second step slowly adds in the aqueous phase of the 3rd step acquisition under constantly stirring, and fully stirs 50 ~ 90 minutes, makes emulsifying, add the mixed-powder that the first step obtains, stir, subpackage at the temperature of 60 DEG C ~ 70 DEG C.
The present invention further provides again the preparation method of the phlebitic Chinese medicine of a kind of above-mentioned treatment Chemotherapy of Tumor Patients, and the dosage form of described Chinese medicine is oral solutions, and it comprises the following steps:
The first step, by Herba Agrimoniae, Lignum cercis chinensis, Cortex Fissistigmatis bracteolati Radicis, Herba Senecionis Kirilowi, Semen Lepidii (Semen Descurainiae), Radix vitis thunbergii (Radix Vitis Adstrictae), Petasites japonicus, Folium Musae, Caulis Achnatheri Splendentis and Radix Calligoni Mongolici mixing, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;
3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours, and refrigerated storage temperature is 2 DEG C ~ 6 DEG C;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine oral liquid finished product.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1: unguentum
Get Herba Agrimoniae 150g, Lignum cercis chinensis 220g, Cortex Fissistigmatis bracteolati Radicis 250g, Herba Senecionis Kirilowi 160g, Semen Lepidii (Semen Descurainiae) 180g, Radix vitis thunbergii (Radix Vitis Adstrictae) 140g, Petasites japonicus 240g, Folium Musae 150g, Caulis Achnatheri Splendentis 120g, Radix Calligoni Mongolici 120g, Herba potamogetonis distincti 220g, Herba Pentanematis Indici 160g, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 180g, Scytosiphon lomentarius (Lyngh.)J. Ag. 150g, Herba Stachytarphetae Jamaicensis 150g and Herba Limnophilae Aromaticae 240g.
Its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, decocts with water 4 times, each 3 hours, add the water of 9 times amount, decoction liquor is filtered at every turn, merge the filtrate of each time, add determining alcohol be 95% ethanol to alcohol content be 55%, leave standstill 5 hours, filter, filtrate concentrates, and drying is also pulverized, and obtains mixed-powder, cross 200 mesh sieves, adopt ultra violet lamp sterilizing in 2 hours;
Second step, relative to mixed-powder described in 100 weight portions that the first step obtains, 2.5 weight portion stearic acid, 0.9 weight portion stearyl alcohol, 1.3 weight portion glyceryl monostearates, 4.2 weight portion liquid Paraffin, 9 weight portion dimethicones are mixed and heated to 75 DEG C ~ 85 DEG C, under constantly stirring, add 3 part by weight of vitamin E dissolve, obtain oil phase;
1.5 weight portion sodium lauryl sulphates, 0.8 weight portion triethanolamine, 1.4 weight portion ethyl hydroxybenzoates, 1400 weight portion distilled water relative to mixed-powder described in 100 weight portions that the first step obtains, are mixed and heated to 85 DEG C, obtain aqueous phase by the 3rd step;
4th step, the oil phase obtained by second step slowly adds in the aqueous phase of the 3rd step acquisition under constantly stirring, and fully stirs 70 minutes, makes emulsifying, add the mixed-powder that the first step obtains, stir, subpackage at the temperature of 65 DEG C.
Embodiment 2: oral solutions
Get Herba Agrimoniae 180g, Lignum cercis chinensis 190g, Cortex Fissistigmatis bracteolati Radicis 280g, Herba Senecionis Kirilowi 140g, Semen Lepidii (Semen Descurainiae) 220g, Radix vitis thunbergii (Radix Vitis Adstrictae) 100g, Petasites japonicus 260g, Folium Musae 120g, Caulis Achnatheri Splendentis 150g, Radix Calligoni Mongolici 80g, Herba potamogetonis distincti 260g, Herba Pentanematis Indici 140g, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 220g, Scytosiphon lomentarius (Lyngh.)J. Ag. 120g, Herba Stachytarphetae Jamaicensis 180g and Herba Limnophilae Aromaticae 200g.
Its preparation method comprises the following steps:
The first step, by Herba Agrimoniae, Lignum cercis chinensis, Cortex Fissistigmatis bracteolati Radicis, Herba Senecionis Kirilowi, Semen Lepidii (Semen Descurainiae), Radix vitis thunbergii (Radix Vitis Adstrictae), Petasites japonicus, Folium Musae, Caulis Achnatheri Splendentis and Radix Calligoni Mongolici mixing, add relative to mixture 4 times amount determining alcohol be 65% alcohol reflux 2 times, each 2 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.301, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 times of water gagings, boils 3 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.28;
3rd step, the described mastic mixing that the first step, second step are obtained, 60 DEG C of reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 hours, and refrigerated storage temperature is 5 DEG C;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001; The time of described heat treated is 30 minutes, and temperature is 100 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine oral liquid finished product.
Toxicity test:
Medicine for external use toxicity test:
1, experimental technique: depilatory is evenly coated by 4 groups of Cavia porcelluss (often organizing 15) spinal column both sides, back, makes unhairing scope about 40 square centimeters.Clean depilatory returns cage to observe 24 hours, wherein three groups, often organize Cavia porcellus and be coated with Chinese medicine embodiment 1 unguentum diluent 0.3,0.5 of the present invention and 0.8ml respectively, respectively containing crude drug 78mg, 130mg and 208mg, another group is coated with solvent 0.8ml, every twice-daily, continuous one week, after experiment terminates, Cavia porcellus is put to death, the heart, liver, kidney and depilation skin do pathological examination.
2, result: above-mentioned three groups of medication Cavia porcellus trunks depilation district, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group Cavia porcellus chroma of hair, ingest, matched group no significant difference, histopathologic examination, the medication group heart, liver, kidney and depilation skin and the matched group more also no significant difference such as extremity are movable.
Result is pointed out, and Chinese medicine for external application of the present invention, without local irritant effect, also has no general toxicity performance.Show Chinese medicine for external application use safety of the present invention.
Acute toxicity testing: application mice 60, male and female half and half, body weight 18-30g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, fasting 12 hours before experiment, the extract oral liquor prepared by embodiments of the invention 2 is dissolved in water, (concentration is 8.64g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 43.2 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage oral solutions LD50>43.2 crude drug/kg of the present invention, every day, maximum dosage-feeding was 86.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 8.52g crude drug/day/people, adult body weight in 60KG, average dosage is 0.142g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 24g) oral administration gavage Chinese medicine of the present invention is 608 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine embodiment 2 oral solutions of the present invention to three groups of mices (often organize 20) by 13.26,25.42 and 42.38g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection: all 80 routine cases all derive from this Out-patient Department and inpatient, all because of intravenous applications chemotherapeutics, phlebitis occur.Man 37 example, female 43 example, age 36-70 year; Wherein, breast carcinoma 26 example, esophageal carcinoma 23 example, pulmonary carcinoma 18 example, gastric cancer 13 example.Be divided into treatment group and each 40 people of matched group at random, treatment group 40 people, man 18 example, female 22 example, age 36-66 year; Wherein, mammary cancer 13 example, esophageal carcinoma 12 example, pulmonary carcinoma 9 example, gastric cancer 6 example.Matched group 40 people, man 19 example, female 21 example, age 38-70 year; Wherein, mammary cancer 13 example, esophageal carcinoma 11 example, pulmonary carcinoma 9 example, gastric cancer 7 example.Treatment group and matched group be no significant difference (P > 0.05) on age and clinical symptoms, has comparability.
Diagnostic criteria: the diagnosis of chemotherapeutic phlebitis and classification are comparatively normal clinically at present, and what adopt is the standard of venous transfusion nurses association of the U.S.: 0 degree: transfusion part is without red, swollen, hot, bitterly and sense of discomfort.I grade: point of puncture local pain, red and swollen or edema, vein, without streak change, does not touch scleroma.II grade: point of puncture local pain, red and swollen or edema, vein has streak change, does not touch scleroma.III grade: point of puncture local pain, red and swollen or edema, vein has streak change, touches scleroma.
Therapeutic Method:
Treatment group: by the unguentum uniform application of Chinese medicine embodiment 1 of the present invention in affected part, every 6-8h changes dressings 1 time.7 days courses for the treatment of.
Matched group: to be drenched by gauze with 33% Adlerika and directly spread on affected part afterwards, every 3-4h changes dressings 1 time, 7 days courses for the treatment of.
Meanwhile, vegetable and fruit diet and symptomatic treatment is kept two groups of every days.Treat and within first 1 week, stop using that all may affect the relevant medicine of test effect, and in therapeutic process, do not use medicine or the health product of other treatment chemotherapeutic phlebitis.
Curative effect judging standard: clinical cure: local skin is red, swollen, hot, pain transference cure, and the complete deliquescing of vein, changes without bar rope sample, and scleroma disappears.Effective: local skin is red, swollen, hot, pain transference cure, vein without scleroma, the deliquescing of bar rope sample red line, color reduction.Effective: localized heat, alleviation of pain are light, red, swollen area disappears >=and 60%, vein is without scleroma, and the deliquescing of bar rope sample red line, color does not go down.Invalid: disease is without improvement or improve less.
Therapeutic outcome: two groups treat 1 course for the treatment of respectively after, statistical result is see table 1 and table 2.
Table 1 liang group treats Clinical efficacy comparison (unit: example) after 1 course for the treatment of respectively
Group Number of cases Cure Effective Effectively Invalid Total effective rate
Treatment group 40 27 8 4 1 39(97.5％)
Matched group 40 13 12 7 8 32(80％)
As can be seen from Table 1, adopt treatment by Chinese herbs chemotherapeutic phlebitis of the present invention, relative to matched group on therapeutic effect, there is significant improvement.
After a table 2 liang group treats 1 course for the treatment of respectively, healing number and time compare (unit: example)
Group Number of cases Medication 2 days Medication 4 days Medication 7 days
Treatment group 27 8(20％) 18(45％) 27(67.5％)
Matched group 13 4(10％) 9(22.5％) 13(32.5％)
As can be seen from Table 2, adopt treatment by Chinese herbs chemotherapeutic phlebitis of the present invention, relative to matched group, treatment the course for the treatment of on significantly shorten.
Concrete case: high certain, female, 59 years old, there is phlebitis, point of puncture local pain in after chemotherapy second day in the intravenous chemotherapy because suffering from breast carcinoma, and red and swollen, vein has streak change, does not touch scleroma, is diagnosed as II chemotherapeutic phlebitis of 2 level and 3.Through smearing the unguentum of the embodiment of the present invention 1, within every 6 hours, smear once, treat local skin after 3 days red, swollen, hot, pain transference cure, the complete deliquescing of vein, without bar rope sample change, clinical cure, follow up a case by regular visits to 1 month without recur.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. the phlebitic Chinese medicine for the treatment of Chemotherapy of Tumor Patients, it is characterized in that, described Chinese medicine comprises following raw medicinal material: Herba Agrimoniae, Lignum cercis chinensis, Cortex Fissistigmatis bracteolati Radicis, Herba Senecionis Kirilowi, Semen Lepidii (Semen Descurainiae), Radix vitis thunbergii (Radix Vitis Adstrictae), Petasites japonicus, Folium Musae, Caulis Achnatheri Splendentis, Radix Calligoni Mongolici, Herba potamogetonis distincti, Herba Pentanematis Indici, Herba Desmodii Triquetri (Herba Tadehagi Triquetri), Scytosiphon lomentarius (Lyngh.)J. Ag., Herba Stachytarphetae Jamaicensis and Herba Limnophilae Aromaticae and Herba Limnophilae Aromaticae.
2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba Agrimoniae 10 ~ 20 parts, Lignum cercis chinensis 15 ~ 25 parts, Cortex Fissistigmatis bracteolati Radicis 20 ~ 30 parts, Herba Senecionis Kirilowi 10 ~ 20 parts, Semen Lepidii (Semen Descurainiae) 15 ~ 25 Fen, Radix vitis thunbergii (Radix Vitis Adstrictae) 10 ~ 20 parts, Petasites japonicus 20 ~ 30 parts, Folium Musae 10 ~ 20 parts, Caulis Achnatheri Splendentis 10 ~ 20 parts, Radix Calligoni Mongolici 5 ~ 15 parts, Herba potamogetonis distincti 20 ~ 30 parts, Herba Pentanematis Indici 10 ~ 20 parts, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 15 ~ 25 parts, Scytosiphon lomentarius (Lyngh.)J. Ag. 10 ~ 20 parts, Herba Stachytarphetae Jamaicensis 15 ~ 25 parts and Herba Limnophilae Aromaticae 20 ~ 30 parts.
3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba Agrimoniae 15 ~ 20 parts, Lignum cercis chinensis 17 ~ 22 parts, Cortex Fissistigmatis bracteolati Radicis 25 ~ 30 parts, Herba Senecionis Kirilowi 12 ~ 17 parts, Semen Lepidii (Semen Descurainiae) 18 ~ 23 Fen, Radix vitis thunbergii (Radix Vitis Adstrictae) 10 ~ 15 parts, Petasites japonicus 23 ~ 28 parts, Folium Musae 12 ~ 17 parts, Caulis Achnatheri Splendentis 10 ~ 15 parts, Radix Calligoni Mongolici 8 ~ 13 parts, Herba potamogetonis distincti 22 ~ 27 parts, Herba Pentanematis Indici 13 ~ 18 parts, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 17 ~ 22 parts, Scytosiphon lomentarius (Lyngh.)J. Ag. 10 ~ 15 parts, Herba Stachytarphetae Jamaicensis 15 ~ 20 parts and Herba Limnophilae Aromaticae 20 ~ 25 parts.
4. the Chinese medicine as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba Agrimoniae 18 parts, Lignum cercis chinensis 19 parts, Cortex Fissistigmatis bracteolati Radicis 28 parts, Herba Senecionis Kirilowi 14 parts, Semen Lepidii (Semen Descurainiae) 22 Fen, Radix vitis thunbergii (Radix Vitis Adstrictae) 10 parts, Petasites japonicus 26 parts, Folium Musae 12 parts, Caulis Achnatheri Splendentis 15 parts, Radix Calligoni Mongolici 8 parts, Herba potamogetonis distincti 26 parts, Herba Pentanematis Indici 14 parts, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 22 parts, Scytosiphon lomentarius (Lyngh.)J. Ag. 12 parts, Herba Stachytarphetae Jamaicensis 18 parts and Herba Limnophilae Aromaticae 20 parts.
5. the Chinese medicine as described in Claims 1-4, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba Agrimoniae 15 parts, Lignum cercis chinensis 22 parts, Cortex Fissistigmatis bracteolati Radicis 25 parts, Herba Senecionis Kirilowi 16 parts, Semen Lepidii (Semen Descurainiae) 18 Fen, Radix vitis thunbergii (Radix Vitis Adstrictae) 14 parts, Petasites japonicus 24 parts, Folium Musae 15 parts, Caulis Achnatheri Splendentis 12 parts, Radix Calligoni Mongolici 12 parts, Herba potamogetonis distincti 22 parts, Herba Pentanematis Indici 16 parts, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 18 parts, Scytosiphon lomentarius (Lyngh.)J. Ag. 15 parts, Herba Stachytarphetae Jamaicensis 15 parts and Herba Limnophilae Aromaticae 24 parts.
6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is unguentum, and its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, decocts with water 2 ~ 4 times, each 2 ~ 5 hours, add the water of 6 ~ 10 times amount, decoction liquor is filtered at every turn, merge the filtrate of each time, add determining alcohol be 90% ~ 95% ethanol to alcohol content be 50% ~ 60%, leave standstill 3 ~ 5 hours, filter, filtrate concentrates, and drying is also pulverized, and obtains mixed-powder, cross 200 mesh sieves, adopt ultra violet lamp sterilizing in 1 ~ 2 hour;
Second step, relative to mixed-powder described in 100 weight portions that the first step obtains, 1 weight portion ~ 3 weight portion stearic acid, 0.5 weight portion ~ 1.5 weight portion stearyl alcohol, 0.5 weight portion ~ 1.5 weight portion glyceryl monostearate, 3 weight portion ~ 5 weight portion liquid Paraffin, 8 weight portion ~ 10 weight portion dimethicones are mixed and heated to 75 DEG C ~ 85 DEG C, under constantly stirring, add 1 weight portion ~ 3 part by weight of vitamin E dissolve, obtain oil phase;
3rd step, relative to mixed-powder described in 100 weight portions that the first step obtains, 0.5 weight portion ~ 1.5 weight portion sodium lauryl sulphate, 0.5 weight portion ~ 1.5 weight portion triethanolamine, 1 weight portion ~ 2 weight portion ethyl hydroxybenzoate, 1000 weight portion ~ 1500 weight portion distilled water are mixed and heated to 75 DEG C ~ 85 DEG C, obtain aqueous phase;
4th step, the oil phase obtained by second step slowly adds in the aqueous phase of the 3rd step acquisition under constantly stirring, and fully stirs 50 ~ 90 minutes, makes emulsifying, add the mixed-powder that the first step obtains, stir, subpackage at the temperature of 60 DEG C ~ 70 DEG C.
7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is oral solutions, and its preparation method comprises the following steps:
The first step, by Herba Agrimoniae, Lignum cercis chinensis, Cortex Fissistigmatis bracteolati Radicis, Herba Senecionis Kirilowi, Semen Lepidii (Semen Descurainiae), Radix vitis thunbergii (Radix Vitis Adstrictae), Petasites japonicus, Folium Musae, Caulis Achnatheri Splendentis and Radix Calligoni Mongolici mixing, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;
3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours, and refrigerated storage temperature is 2 DEG C ~ 6 DEG C;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine oral liquid finished product.
8. a preparation method for the Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is unguentum, and its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, decocts with water 2 ~ 4 times, each 2 ~ 5 hours, add the water of 6 ~ 10 times amount, decoction liquor is filtered at every turn, merge the filtrate of each time, add determining alcohol be 90% ~ 95% ethanol to alcohol content be 50% ~ 60%, leave standstill 3 ~ 5 hours, filter, filtrate concentrates, and drying is also pulverized, and obtains mixed-powder, cross 200 mesh sieves, adopt ultra violet lamp sterilizing in 1 ~ 2 hour;
Second step, relative to mixed-powder described in 100 weight portions that the first step obtains, 1 weight portion ~ 3 weight portion stearic acid, 0.5 weight portion ~ 1.5 weight portion stearyl alcohol, 0.5 weight portion ~ 1.5 weight portion glyceryl monostearate, 3 weight portion ~ 5 weight portion liquid Paraffin, 8 weight portion ~ 10 weight portion dimethicones are mixed and heated to 75 DEG C ~ 85 DEG C, under constantly stirring, add 1 weight portion ~ 3 part by weight of vitamin E dissolve, obtain oil phase;
3rd step, relative to mixed-powder described in 100 weight portions that the first step obtains, 0.5 weight portion ~ 1.5 weight portion sodium lauryl sulphate, 0.5 weight portion ~ 1.5 weight portion triethanolamine, 1 weight portion ~ 2 weight portion ethyl hydroxybenzoate, 1000 weight portion ~ 1500 weight portion distilled water are mixed and heated to 75 DEG C ~ 85 DEG C, obtain aqueous phase;
4th step, the oil phase obtained by second step slowly adds in the aqueous phase of the 3rd step acquisition under constantly stirring, and fully stirs 50 ~ 90 minutes, makes emulsifying, add the mixed-powder that the first step obtains, stir, subpackage at the temperature of 60 DEG C ~ 70 DEG C.
9. a preparation method for the Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is oral solutions, and its preparation method comprises the following steps:
The first step, by Herba Agrimoniae, Lignum cercis chinensis, Cortex Fissistigmatis bracteolati Radicis, Herba Senecionis Kirilowi, Semen Lepidii (Semen Descurainiae), Radix vitis thunbergii (Radix Vitis Adstrictae), Petasites japonicus, Folium Musae, Caulis Achnatheri Splendentis and Radix Calligoni Mongolici mixing, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;
3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours, and refrigerated storage temperature is 2 DEG C ~ 6 DEG C;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine oral liquid finished product.
CN201511025810.3A 2015-12-30 2015-12-30 Traditional Chinese medicine for treating chemotherapeutic phlebitis of tumor patient and preparation method thereof Pending CN105456794A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101744899A (en) * 2008-12-18 2010-06-23 侯春华 Traditional Chinese medicine paste for treating chemotherapy phlebitis vasospasm stage and preparation
CN105125714A (en) * 2015-10-25 2015-12-09 李芳华 Traditional Chinese medicine preparation for treating chemotherapeutic phlebitis and preparing method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101744899A (en) * 2008-12-18 2010-06-23 侯春华 Traditional Chinese medicine paste for treating chemotherapy phlebitis vasospasm stage and preparation
CN105125714A (en) * 2015-10-25 2015-12-09 李芳华 Traditional Chinese medicine preparation for treating chemotherapeutic phlebitis and preparing method thereof

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