CN106491790A - One kind is used for antipsoriatics compositions - Google Patents
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Abstract
The invention discloses a kind of for antipsoriatics compositions, it is made up of the crude drug of following weight portion：10 50 parts of Radix Rumiciss, Cortex Dictamni 10 30,10 20 parts of Radix Sophorae Flavescentiss, 10 20 parts of Cortex Cleistocalycis Operculati, 10 20 parts of Mosla dianthera, 10 20 parts of Cortex Phellodendri, 0.1 0.5 parts of Borneolum Syntheticum, 0.1 0.5 parts of Oleum Terebinthinae.Rationally, special treatment, each herbal medicine synergism, with functions such as nourishing blood and promoting blood circulation, Runzao Zhiyangs, have good curative effect, the pain of effectively solving patient to prescription compatibility of medicines of the present invention to various psoriasiss.
Description
Technical field
The invention belongs to medicine field, it is related to one kind and treats psoriasic to play nourishing blood and promoting blood circulation, Runzao Zhiyang effect
Pharmaceutical composition.
Background technology
Psoriasiss are called psoriasises, are a kind of dermatosis chronic diseases of common chronic, obstinate, easy recurrence, it is characterized in that occurring
The pimple for differing in size, erythema, surface are covered with silvery white squama, clear border, and squama occurs blood point after coming off.General
Side and back is stretched in scalp, extremity.Patient's physical and mental health is had a direct impact.Differential diagnosis in tcm analysis is pressed, psoriasiss there are " blood
Dry, heat in blood, blood deficiency " as and saying from the angle of doctor trained in Western medicine, being then that various biochemical metabolisms are disorderly due to keratinocyte hyperproliferation
Caused.At present, western medical treatment psoriasiss mainly eliminate symptom, it is to avoid further deteriorate, it is impossible to effect a radical cure, and side effect compared with
Greatly.And Chinese traditional treatment psoriasiss are mainly nursed one's health to blood, including blood enriching and dryness moistening method, method of dissipating heat and detoxifying, promoting blood circulationization
Stasis of blood method etc., the recovery to the state of an illness are highly beneficial, can reach the purpose for the treatment of both the principal and secondary aspects of a disease.Treat psoriasic related preparations there is not yet
Radix Rumiciss, Cortex Dictamni, Radix Sophorae Flavescentiss, Cortex Cleistocalycis Operculati, Mosla dianthera, Cortex Phellodendri, Borneolum Syntheticum, the report of Lignum Pini Nodi fluid composition.
(1) Radix Rumiciss, are the root of polygonaceae plant Radix Rumicis Japonici RumexjaponicusHoutt..【Nature and flavor and return through】Pungent；Bitter；Property
Cool.Return lung；Spleen；Large intestine channel.【Function with cure mainly】Heat-clearing and toxic substances removing；Cooling blood for hemostasis；Removing blood stasis to reduce swelling；Relieving constipation；Parasite killing.Main pulmonary tuberculosis are coughed
Blood；Pain in the lung；Spit blood；Stasis of blood；Traumatic injury；Constipation；Mumps；Ulcerative carbuncle pyogenic infections；Scald；Scabies；Eczema.
(2) Cortex Dictamni, dry root skin of this product for rutaceae shaggy-fruited dittany Dictamnus dasycarpus Turcz..
Chinese Pharmacopoeia 2015 editions one is recorded：【Nature and flavor and return through】Hardship, trembles with fear.Returns spleen, stomach, bladder warp.【Function with cure mainly】Heat clearing and damp drying,
Wind-dispelling is detoxified.For damp and hot sore, yellow fluid is dripping, wet, rubella, scabies skin ulcer leprosy, beriberoid pyretic arthralgia, jaundice urine is red.
(3) Radix Sophorae Flavescentiss, are the dry root of leguminous plant Radix Sophorae Flavescentiss Sophora flavescens Ait..Chinese Pharmacopoeia 2015 editions
One is recorded：【Nature and flavor and return through】Hardship, trembles with fear.GUIXIN, liver, stomach, large intestine, bladder warp.【Function with cure mainly】Heat clearing and damp drying, parasite killing,
Diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy, outward
Control trichomonal vaginitis.
(4) Cortex Cleistocalycis Operculati, is myrtle water father-in-law Cleistocalyx operculatus (Roxb.) Merr.et
The bark of Perry.【Nature and flavor】Bitter in the mouth；Pungent；Cool in nature.【Function with cure mainly】Heat-clearing and toxic substances removing；Dampness；Parasite killing.Main tinea pedis is wet rotten；Wet
Rash；Scabies；Scrotum carbuncle；Burn and scald.
(5) Mosla dianthera, is the herb of labiate flower thinning shepherd's purse Mosla dianthera (Ham.) Maxim.【Property
Taste and return through】Acrid in the mouth；Bitter；Slightly warm in nature.Return lung；Spleen；Stomach【Function with cure mainly】Deliver driving away summer heat；Dampness removing is with；Detumescence hemostasis；Dissipate
Wind is antipruritic.Cure mainly anemofrigid cold；Febrile disease of YIN type in summer is had a headache；Nausea；Gastralgia；Hakuri；Edema；Epistaxis；Hemorrhoidal bleeding；Furuncle；Pudendal pruritus；Eczema；Miliaria
Poison；Traumatic hemorrhage；Snake bite and insect sting.
(6) Cortex Phellodendri, is the dry bark of rutaceae wampee Phellodendron chinense Schneid..
Chinese Pharmacopoeia 2015 editions one is recorded：【Nature and flavor and return through】Hardship, trembles with fear.Return ' kidney, bladder warp.【Function with cure mainly】Heat clearing and damp drying, rushes down
Fire is except steaming, detoxification sore treatment.For damp-heat dysentery, jaundice urine is red, leukorrhagia pudendal pruritus, puckery pain of heat gonorrhea, tinea pedis flaccidity are knitted, and hectic fever due to YIN-deficiency consumptive fever is stolen
Antiperspirant, seminal emission, sore swollen toxin, eczema eczema.
(7) Borneolum Syntheticum, is divided to BORNEOLUM SYNTHETICUM and two class of Blumeae preparatum Tabellae.BORNEOLUM SYNTHETICUM is raw material through chemical method with Oleum Terebinthinae, Camphora etc.
The Borneolum Syntheticum of synthesis；Blumeae preparatum Tabellae for Compositae Herba Blumeae Balsamiferae platymiscium Balsamiferou Blumea Herb fresh leaf through steam distillation, cooling gained crystallization, also known as Chinese mugwort
Powder or sheeting.【Nature and flavor】Pungent, bitter, it is slightly cold.【Return through】GUIXIN, spleen, lung meridian.【Function with cure mainly】Inducing resuscitation of having one's ideas straightened out, clearing away heat to alleviate pain.With
In calentura coma, convulsions, apoplexy syncope due to accumulation of phlegm, bstruction of the circulation of vital energy is fainted cruelly, middle evil is gone into a coma, conjunctival congestion, aphtha, laryngopharynx swelling and pain, auditory meatus are suppurated.
(8) Oleum Terebinthinae, is the oleoresin oozed out in Pinaceae Pinus several plants, through distilling or extracting the volatile oil for obtaining.
【Function with cure mainly】Promoting blood circulation to remove obstruction in the collateral；Reducing swelling and alleviating pain.Main joint swells and ache；Myalgia；Traumatic injury.
Content of the invention
It is an object of the invention to provide a kind of for treating psoriasiss good effect, instant effect, can up to treating both the principal and secondary aspects of a disease and more after
It is difficult pharmaceutical composition of recurrence and preparation method thereof.
The present invention is on the basis of Chinese medicine traditional theory, in conjunction with use among the people for antipsoriatics compositions
Medicine experience, is formulated with modern scientific theory.Have prescription rigorous, the few power of medicine specially, for treat various psoriasiss have good
Good curative effect, the pain of effectively solving patient.
The technical solution adopted in the present invention is as follows：
One kind is grouped into by the group of following weight portion for antipsoriatics compositions：Radix Rumiciss 10-50 parts,
Cortex Dictamni 10-30 parts, Radix Sophorae Flavescentiss 10-20 parts, Cortex Cleistocalycis Operculati 10-20 parts, Mosla dianthera 10-20 parts, Cortex Phellodendri 10-20 parts, Borneolum Syntheticum 0.1-
0.5 part, Oleum Terebinthinae 0.1-0.5 parts.
Above-described for antipsoriatics compositions, be preferably grouped into by the group of following weight portion：Native big
Yellow 20-40 parts, Cortex Dictamni 20-30, Radix Sophorae Flavescentiss 15-20 parts, Cortex Cleistocalycis Operculati 10-15 parts, Mosla dianthera 10-15 parts, Cortex Phellodendri 10-15 parts,
Borneolum Syntheticum 0.1-0.3 parts, Oleum Terebinthinae 0.1-0.3 parts.
Above-described for antipsoriatics compositions, be most preferably preferably grouped into by the group of following weight portion：
30 parts of Radix Rumiciss, Cortex Dictamni 20,15 parts of Radix Sophorae Flavescentiss, 12 parts of Cortex Cleistocalycis Operculati, 12 parts of Mosla dianthera, 12 parts of Cortex Phellodendri, 0.2 part of Borneolum Syntheticum, Lignum Pini Nodi
0.2 part of oil.
Above-described for antipsoriatics compositions, any external preparation that allow on medicine can be prepared into
Type, such as：Ointment, ointment, paste, liniment, varnish, tincture, gel etc., are preferably made tincture.
More than one described preparation methoies for being prepared into tincture for antipsoriatics compositions, including following step
Suddenly：
(1) fetch earth respectively Radix Et Rhizoma Rhei, Cortex Dictamni, Radix Sophorae Flavescentiss, Cortex Cleistocalycis Operculati, Mosla dianthera, Cortex Phellodendri, clean, dry；
(2) weigh by weight：Radix Rumiciss 10-50 parts, Cortex Dictamni 10-30 parts, Radix Sophorae Flavescentiss 10-20 parts, Cortex Cleistocalycis Operculati 10-20
Part, Mosla dianthera 10-20 parts, Cortex Phellodendri 10-20 parts；
(3) by load weighted above-mentioned 6 taste Chinese medicine, plus 8-10 times is measured 50%-70% ethanol and is soaked 30 days, is stirred every 6 days
Once, filter, add Borneolum Syntheticum, Oleum Terebinthinae to stir evenly, obtain final product.
Further, under step (3) item, the concentration of the ethanol is preferably 60%, and the addition of the ethanol is preferably 9
Measure again.
In the present invention, Radix Rumiciss are monarch drug in side, with heat-clearing and toxic substances removing, cooling blood for hemostasis, removing blood stasis to reduce swelling, relieving constipation, parasite killing it
Work(, cures mainly tuberculosis hemoptysis, and pain in the lung is spitted blood, and stasis of blood, traumatic injury, constipation, mumps, ulcerative carbuncle pyogenic infections are scalded；Scabies；
Eczema.Cortex Dictamni, Radix Sophorae Flavescentiss, Cortex Cleistocalycis Operculati, Mosla dianthera, Cortex Phellodendri are respectively provided with the work(antipruritic for heat clearing and damp drying, promoting blood circulation, are Fang Zhongchen
Medicine.Borneolum Syntheticum is adjuvant drug in side；Oleum Terebinthinae is to make medicine in side.Prescription compatibility of medicines of the present invention rationally, make by special treatment, each herbal medicine collaboration
With, the effects such as with nourishing blood and promoting blood circulation, Runzao Zhiyang, for treating psoriasiss good effect, instant effect, there is the effect for the treatment of both the principal and secondary aspects of a disease,
Can be up to the target of difficulty in relapse after healing.
Specific embodiment
With reference to specific embodiment, the invention will be further described, but do not limit the scope of the invention and apply
Scope：
First, the preparation of tincture
1. EXPERIMENTAL DESIGN：
This test is prepared into tincture respectively with 5 embodiments, and design parameter refers to table 1.
1 tincture embodiment preparation parameter table of table
| Embodiment | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| Radix Rumiciss (kg) | 1 | 2 | 5 | 3 | 4 |
| Cortex Dictamni (kg) | 1 | 2 | 3 | 2 | 3 |
| Radix Sophorae Flavescentiss (kg) | 1 | 1.5 | 2 | 1.5 | 2 |
| Cortex Cleistocalycis Operculati (kg) | 1 | 1 | 2 | 1.2 | 1.5 |
| Mosla dianthera (kg) | 1 | 1 | 2 | 1.2 | 1.5 |
| Cortex Phellodendri (kg) | 1 | 1 | 2 | 1.2 | 1.5 |
| Borneolum Syntheticum (kg) | 0.01 | 0.03 | 0.05 | 0.02 | 0.04 |
| Oleum Terebinthinae (kg) | 0.01 | 0.03 | 0.05 | 0.02 | 0.04 |
| Solvent | 50% ethanol | 60% ethanol | 70% ethanol | 60% ethanol | 70% ethanol |
| Solvent measures (again) again | 8 | 9 | 10 | 9 | 10 |
2. operating procedure：
(1) fetch earth respectively Radix Et Rhizoma Rhei, Cortex Dictamni, Radix Sophorae Flavescentiss, Cortex Cleistocalycis Operculati, Mosla dianthera, Cortex Phellodendri, clean, dry；
(2) weigh by weight：Radix Rumiciss 10-50 parts, Cortex Dictamni 10-30 parts, Radix Sophorae Flavescentiss 10-20 parts, Cortex Cleistocalycis Operculati 10-20
Part, Mosla dianthera 10-20 parts, Cortex Phellodendri 10-20 parts；
(3) by load weighted above-mentioned 6 taste Chinese medicine, plus 8-10 times is measured 50%-70% ethanol and is soaked 30 days, is stirred every 6 days
Once, filter, add Borneolum Syntheticum, Oleum Terebinthinae to stir evenly, obtain final product.
2nd, clinical practice
1st, diagnostic criteria
Homeliness type psoriasiss：Erythra typically occurs in scalp, trunk, extremity and stretches side, the pimple for occurring redness on skin, table
There are thicker silvery white phosphorus bits in face, in Caulis et folium pavettae hongkongensiss outward appearance, with skin pruritus.
Erythrodermic psoriasiss：More than 70%, kermesinus wellability skin lesion red in diffusivity of about whole skin, surface
There are a large amount of bran skin sample scurfs, with skin pruritus.
Pustular psoriasis：General whole body of pustule, has the potential pimple of intensive needle point size, is often accompanied by hyperpyrexia, pass
Section swells and ache, skin pruritus and general malaise, and routine blood test chemically examines visible leukocytosiss, and after abscess is dry, desquamation immediately, scurf take off
Fall behind, have new abscess to occur again.
Psoriasis arthropathica：Common is wrist, finger and toes Minor articulus, and there are redness, pain, serious joint in joint
There are hydrops, juxtra-articular skin turgor limitation of activity, long joint stiffness, the destroyed feelings of visible joint under x-ray when serious in chamber
Condition, erythrocyte sedimentation rate are fast, and often occur together the general malaises such as heat, skin pruritus
2nd, curative effect mark Huaihe River
Symptom all disappears for curing, and symptom mitigation is effective, and symptom is not changed in as invalid.
3. medication
(1) treatment group：The product of embodiment 1-4 is directly put outward in affected part on the skin, and 2-3 time on the 1st, continuous 3 weeks be a course for the treatment of.
(2) matched group:Affected part is directly outer to put naftifine hydrochloride and ketoconazole cream on the skin, 2-3 time on the 1st, is within continuous 3 weeks a course for the treatment of.
4th, result is applied
The present invention is used for antipsoriatics compositions, is once used for treating and observing 166 patients or volunteer.Will
The above-mentioned 4 kinds of embodiment samples for preparing, are respectively used to following 4 kinds of different types of patients or volunteer.A:Homeliness type Corii Bovis seu Bubali
Tinea (totally 44, man 20, female 24,32.0 years old mean age), B:Erythrodermic psoriasiss (totally 42, man 25, female 17
Example, 34.7 years old mean age), C:Pustular psoriasis：(totally 40, man 20, female 20,32.9 years old mean age), D:Close
Section characteristic of disease psoriasiss (totally 40, man 22, female 18,42.8 years old mean age).Each embodiment sample and control sample
Product are used for the case of upper each type and are no less than 5.The results are shown in Table 2.
Result table applied by table 2
As a result show：Using the embodiment of the present invention to the psoriasis treatment effect of four types than control sample treatment
Effect is slightly good, illustrates that pharmaceutical composition of the present invention has good curative effect to psoriasiss, can reach the purpose for solving patient suffering.
It is below several model cases：
Case 1：Beam ××, female, 30 years old, with homeliness type psoriasiss cardinal symptom.Using (embodiment 2) of the invention, put on the skin outward
Affected part, 2 times a day, is used in conjunction 21, and psoriasis symptoms disappear substantially, recovery from illness, then with 7 days, has no recurrence in March.
Case 2：Agriculture ××, man, 47 years old, hospital diagnosis were psoriasis arthropathica.Using of the invention (embodiment 3), outward
Put affected part on the skin, 3 times a day, be used in conjunction 30, psoriasis symptoms disappear, recovery from illness.
Case 3：Poplar ××, man, 33 years old, hospital diagnosis were pustular psoriasis.Using of the invention (embodiment 5), outward
Put 2 times/day on the skin, be used in conjunction 15 days, psoriasis symptoms are greatly improved, generate heat, the symptom that comes to a head disappears, then with 20 days, all symptoms
Disappear, recovery from illness.
Case 4：5 ××s, female, 36 years old, hospital diagnosis were erythrodermic psoriasiss.Using (embodiment 4) of the invention
100ml, plus appropriate hot water, bathing 1/ time, outer apply 3 times, using psoriasis symptoms after 14 days be improved significantly, using 14 days
Afterwards, psoriasis symptoms disappear substantially, recovery from illness.
Case 5：Wu's ××, man, 28 years old, hospital diagnosis were homeliness type psoriasiss.Using (embodiment 1) of the invention, outer painting 3
Times/day, using psoriasis symptoms after 21 days be improved significantly, using 14 days after, psoriasis symptoms disappear substantially, recovery from illness.
Claims (10)
1. a kind of for antipsoriatics compositions, it is characterised in that raw material is grouped into by the group of following weight portion：Soil
Radix Et Rhizoma Rhei 10-50 parts, Cortex Dictamni 10-30 parts, Radix Sophorae Flavescentiss 10-20 parts, Cortex Cleistocalycis Operculati 10-20 parts, Mosla dianthera 10-20 parts, Cortex Phellodendri 10-20
Part, Borneolum Syntheticum 0.1-0.5 parts, Oleum Terebinthinae 0.1-0.5 parts.
2. according to claim 1 for antipsoriatics compositions, it is characterised in that raw material is by following weight
The group of part is grouped into：Radix Rumiciss 20-40 parts, Cortex Dictamni 20-30 parts, Radix Sophorae Flavescentiss 15-20 parts, Cortex Cleistocalycis Operculati 10-15 parts, Mosla dianthera
10-15 parts, Cortex Phellodendri 10-15 parts, Borneolum Syntheticum 0.1-0.3 parts, Oleum Terebinthinae 0.1-0.3 parts.
3. according to claim 1 for antipsoriatics compositions, it is characterised in that raw material is by following weight
The group of part is grouped into：30 parts of Radix Rumiciss, 20 parts of Cortex Dictamni, 15 parts of Radix Sophorae Flavescentiss, 12 parts of Cortex Cleistocalycis Operculati, 12 parts of Mosla dianthera, 12 parts of Cortex Phellodendri,
0.2 part of Borneolum Syntheticum, 0.2 part of Oleum Terebinthinae.
4. according to arbitrary described for antipsoriatics compositions in claim 1-3, it is characterised in that described group
Compound is prepared into external preparation.
5. according to arbitrary described for antipsoriatics compositions in claim 1-3, it is characterised in that described group
Compound is prepared into external preparation for ointment, ointment, paste, liniment, varnish, tincture, gel.
6. according to arbitrary described for antipsoriatics compositions in claim 1-3, it is characterised in that described group
Compound is prepared into tincture.
7. a kind of as claimed in claim 6 be used for the preparation method that antipsoriatics compositions are prepared into tincture, its
It is characterised by, comprises the following steps：
(1) fetch earth respectively Radix Et Rhizoma Rhei, Cortex Dictamni, Radix Sophorae Flavescentiss, Cortex Cleistocalycis Operculati, Mosla dianthera, Cortex Phellodendri, clean, dry；
(2) weigh by weight：Radix Rumiciss 10-50 parts, Cortex Dictamni 10-30 parts, Radix Sophorae Flavescentiss 10-20 parts, Cortex Cleistocalycis Operculati 10-20 parts, little
Fish Herba mesonae chinensis 10-20 parts, Cortex Phellodendri 10-20 parts；
(3) by load weighted above-mentioned 6 taste Chinese medicine, plus 8-10 times is measured 50%-70% ethanol and is soaked 30 days, every stirring in 6 days once,
Filtration, adds Borneolum Syntheticum, Oleum Terebinthinae to stir evenly, obtain final product.
8. a kind of as claimed in claim 7 be used for the preparation method that antipsoriatics compositions are prepared into tincture, its
It is characterised by, the amount of the ethanol added by step (3) is measured for 9 times.
9. a kind of as claimed in claim 7 be used for the preparation method that antipsoriatics compositions are prepared into tincture, its
It is characterised by, the concentration of ethanol added by step (3) is 60%.
10. according to arbitrary described for antipsoriatics compositions in claim 1-7, it is characterised in that the medicine
Purposes of the compositions in antipsoriatics thing is prepared.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201611066181.3A CN106491790A (en) | 2016-11-28 | 2016-11-28 | One kind is used for antipsoriatics compositions |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111991465A (en) * | 2020-08-20 | 2020-11-27 | 方志刚 | A pharmaceutical composition for treating psoriasis and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104758425A (en) * | 2014-01-03 | 2015-07-08 | 陈炜 | Psoriasis treating external application traditional Chinese medicine ointment |
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| CN104758425A (en) * | 2014-01-03 | 2015-07-08 | 陈炜 | Psoriasis treating external application traditional Chinese medicine ointment |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111991465A (en) * | 2020-08-20 | 2020-11-27 | 方志刚 | A pharmaceutical composition for treating psoriasis and preparation method thereof |
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