CN106619955A - Medicinal composition for treating psoriasis and preparation method thereof - Google Patents
Medicinal composition for treating psoriasis and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention discloses a medicinal composition for treating psoriasis and a preparation method thereof. The medicinal composition is prepared from the following bulk pharmaceuticals in parts by weight: 20 to 50 parts of rhubarb root, 10 to 20 parts of lightyellow sophora root, 10 to 30 parts of cleistocalyx operculatus bark, 10 to 30 parts of mosla dianthera, 10 to 30 parts of cortex phellodendri, 0.1 to 0.5 part of borneol and 0.1 to 0.5 part of turpentine. The medicinal composition is reasonable in prescription, is clear in therapeutic principle, has the effects of expelling wind-damp, dredging channel, promoting blood circulation to arrest pain, diminishing inflammation and detoxifying under the synergistic action of the Chinese medicinal herbs, has a good curative effect on various psoriasis, and can effectively relieve pain of patients.
Description
Technical field
The invention belongs to medicine field, be related to one kind treat it is psoriasic can play wines used as antirheumatic, degrading the channel, promoting blood circulation stops
Bitterly, pharmaceutical composition of eliminating inflammation and expelling toxin effect and preparation method thereof.
Background technology
Psoriasis is called psoriasis, is a kind of dermatosis chronic disease of common chronic, obstinate, easy recurrence, it is characterized in that occurring
The papule for differing in size, erythema, surface is covered with the silvery white scales of skin that peel off, clear border, and the scales of skin that peel off occurs blood point after coming off.It is general to send out
Side and back are stretched in scalp, four limbs.Patient's physical and mental health is had a direct impact.Analyze by differential diagnosis in tcm, psoriasis there are " blood
Dry, blood-head, the deficiency of blood " as, and say from the angle of doctor trained in Western medicine, then be that, due to keratinocyte hyperproliferation, various biochemical metabolisms are disorderly
It is caused.At present, western medical treatment psoriasis mainly eliminates symptom, it is to avoid further deteriorate, it is impossible to effect a radical cure, and side effect compared with
Greatly.And Chinese traditional treatment psoriasis is mainly nursed one's health blood, including enriching the blood to restore normal menstruation method, method of dissipating heat and detoxifying, promoting blood circulationization
Stasis of blood method etc., the recovery to the state of an illness is highly beneficial, can reach the purpose treated both principal and secondary aspect of disease.Treat psoriasic related preparations there is not yet
Rumex madaio, kuh-seng, operculate cleistocalyx bark, Mosla dianthera, golden cypress, borneol, the report of turpentine fluid composition.
(1) Rumex madaio, is the root of polygonaceae plant sheep hoof RumexjaponicusHoutt..【Nature and flavor and return through】It is pungent；It is bitter；Property
It is cool.Return lung；Spleen；Large intestine channel.【Function with cure mainly】It is clearing heat and detoxicating；Cooling blood and hemostasis；Eliminating stasis to resolve swelling；Defaecation；Desinsection.Main tuberculosis is coughed
Blood；Lung pain；Spit blood；Stasis of blood；Traumatic injury；Constipation；Mumps；Ulcerative carbuncle pyogenic infections；Scald；Mange；Eczema.
(2) kuh-seng, is the dry root of legume kuh-seng Sophora flavescens Ait..Chinese Pharmacopoeia 2015 editions
One is recorded：【Nature and flavor and return through】Hardship, trembles with fear.The thoughts of returning home, liver, stomach, large intestine, bladder warp.【Function with cure mainly】Heat-clearing and damp-drying drug, desinsection,
Diuresis.For hot dysentery, have blood in stool, jaundice renal shutdown, leukorrhea with reddish discharge, swelling of vulva pruritus vulvae, eczema, wet sore, pruitus, mange leprosy, outward
Control trichomonas vaginitis.
(3) operculate cleistocalyx bark, is myrtle water father-in-law Cleistocalyx operculatus (Roxb.) Merr.et
The bark of Perry.【Nature and flavor】Bitter；It is pungent；It is cool in nature.【Function with cure mainly】It is clearing heat and detoxicating；Eliminating dampness；Desinsection.Main tinea pedis is wet rotten；It is wet
Rash；Mange；Scrotum carbuncle；Burn and scald.
(4) Mosla dianthera, is the herb of labiate flower thinning Ji Ning Mosla dianthera (Ham.) Maxim.【Property
Taste and return through】Taste is pungent；It is bitter；Slightly warm in nature.Return lung；Spleen；Stomach【Function with cure mainly】Deliver driving away summer heat；Dampness removing is with；Detumescence hemostasis；Dissipate
Wind is antipruritic.Cure mainly anemofrigid cold；Yin summer-heat syndrome is had a headache；Nausea；Gastral cavity pain；Dysentery characterized by white mucous stool；Oedema；Bleeding from five sense organs or subcutaneous tissue；Hemorrhoid blood；Boil；Pruritus vulvae；Eczema；Miliaria
Poison；Traumatism and bleeding；Snake bite and insect sting.
(5) golden cypress, is the dry bark of rutaceae wampee Phellodendron chinense Schneid..
Chinese Pharmacopoeia 2015 edition one is recorded：【Nature and flavor and return through】Hardship, trembles with fear.Return ' kidney, bladder warp.【Function with cure mainly】Heat-clearing and damp-drying drug, rushes down
Fire is except steaming, detoxification sore treatment.For damp-heat dysentery, jaundice urine is red, under band pruritus vulvae, puckery pain of heat gonorrhea, tinea pedis impotence is knitted, and hectic fever due to yin labor heat is stolen
Sweat, seminal emission, sore swollen toxin, eczema wet sore.
(6) borneol, is divided to BORNEOLUM SYNTHETICUM and the class of L-Borneol two.BORNEOLUM SYNTHETICUM is with turpentine oil, camphor etc. as raw material Jing chemical methodes
The borneol of synthesis；L-Borneol for composite family Blumea balsamifera platymiscium Balsamiferou Blumea Herb the steam distillation of fresh leaf Jing, cooling obtained by crystallization, also known as Chinese mugwort
Powder or sheeting.【Nature and flavor】Pungent, hardship, is slightly cold.【Return through】The thoughts of returning home, spleen, lung channel.【Function with cure mainly】Inducing resuscitation of having one's ideas straightened out, clearing away heat to and alleviating pain.With
In pyreticosis coma, faint from fear, apoplexy coma due to blocking of the respiratory system, bstruction of the circulation of vital energy is fainted cruelly, middle evil is gone into a coma, hot eyes, aphtha, abscess of throat, duct is suppurated.
(7) turpentine oil, is the oleoresin oozed out in Pinaceae Pinus several plants, Jing distillations or extracts the volatile oil for obtaining.
【Function with cure mainly】It is promoting blood circulation and removing obstruction in channels；Swelling and pain relieving.Main joint swells and ache；Courbature；Traumatic injury.
The content of the invention
It is an object of the invention to provide one kind treats psoriasis good effect, instant effect, can reach and treat both principal and secondary aspect of disease and be difficult more afterwards
External-use tincture of recurrence and preparation method thereof.
Antipsoriatics compositions of the present invention are on the basis of traditional Chinese medicine traditional theory, with reference to medication Jing among the people
Test, be formulated with modern scientific theory.Rigorous with prescription, the few power of medicine specially, has good curative effect to various psoriasis, has
Effect solves the pain of patient.
The technical solution adopted in the present invention is as follows：
A kind of antipsoriatics compositions, are made up of the component of following weight portion：Rumex madaio 20-50 parts, kuh-seng
10-20 parts, operculate cleistocalyx bark 10-30 parts, Mosla dianthera 10-30 parts, golden cypress 10-30 parts, borneol 0.1-0.5 parts, turpentine oil 0.1-0.5
Part.Preferably, described antipsoriatics compositions, are made up of the component of following weight portion：30 parts of Rumex madaio, hardship
15 parts of ginseng, 20 parts of operculate cleistocalyx bark, 15 parts of Mosla dianthera, 15 parts of golden cypress, 0.2 part of borneol, 0.2 part of turpentine oil.
Above-described antipsoriatics compositions, can be prepared into any exterior-applied formulation allowed on medicine, such as：
Ointment, cream, paste, liniment, paint, tincture, gel etc., are preferably made tincture.
More than one antipsoriatics compositions are prepared into the preparation method of tincture, comprise the following steps：
(1) fetch earth respectively rheum officinale, kuh-seng, operculate cleistocalyx bark, Mosla dianthera, golden cypress, clean, be dried；
(2) weigh by weight：Rumex madaio 20-50 parts, kuh-seng 10-20 parts, operculate cleistocalyx bark 10-30 parts, Mosla dianthera 10-30
Part, golden cypress 10-30 parts；
(3) by load weighted above-mentioned 5 taste Chinese medicine, plus 8-10 times is measured 50%-70% ethanol and is soaked 30 days, is stirred every 6 days
Once, filter, add borneol, turpentine oil to stir evenly, obtain final product.
Further, the concentration of the ethanol is preferably 60% under step (3) item, and the addition of the ethanol is preferably 9
Measure again.
Rumex madaio is monarch drug in a prescription in side in the present invention, with clearing heat and detoxicating, cooling blood and hemostasis, eliminating stasis to resolve swelling, defaecation, desinsection it
Work(, cures mainly tuberculosis hemoptysis, and lung pain is spitted blood, and stasis of blood, traumatic injury, constipation, mumps, ulcerative carbuncle pyogenic infections are scalded；Mange；
Eczema.Kuh-seng, operculate cleistocalyx bark, Mosla dianthera, golden cypress are respectively provided with as the antipruritic work(of heat-clearing and damp-drying drug, desinsection, ministerial drug in the side of being.Borneol is
Adjutant in side；Turpentine oil is to make medicine in side.Prescription compatibility of medicines of the present invention rationally, special treatment, each herbal medicine synergy, with dispelling
The functions such as rheumatism, degrading the channel, promoting blood circulation and stopping pain, eliminating inflammation and expelling toxin, treatment psoriasis good effect, instant effect, there is the effect treated both principal and secondary aspect of disease,
The target of difficulty in relapse after healing can be reached.
Specific embodiment
With reference to specific embodiment, the invention will be further described, but do not limit the scope of the invention and apply
Scope：
First, the preparation of tincture
1. experimental design：
This test is prepared into respectively tincture with 4 embodiments, and design parameter refers to table 1.
The tincture embodiment preparation parameter table of table 1
| Embodiment | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 |
| Rumex madaio (kg) | 2 | 5 | 3 | 4 |
| Kuh-seng (kg) | 1 | 2 | 1.5 | 1.8 |
| Operculate cleistocalyx bark (kg) | 1 | 3 | 2 | 2.5 |
| Mosla dianthera (kg) | 1 | 3 | 1.5 | 2 |
| Golden cypress (kg) | 1 | 3 | 1.5 | 2 |
| Borneol (kg) | 0.01 | 0.05 | 0.02 | 0.03 |
| Turpentine oil (kg) | 0.01 | 0.05 | 0.02 | 0.03 |
| Solvent | 50% ethanol | 70% ethanol | 60% ethanol | 60% ethanol |
| Solvent is measured again (again) | 8 | 10 | 9 | 10 |
2. operating procedure：
(1) fetch earth respectively rheum officinale, kuh-seng, operculate cleistocalyx bark, Mosla dianthera, golden cypress, clean, be dried；
(2) weigh by weight：Rumex madaio 20-50 parts, kuh-seng 10-20 parts, operculate cleistocalyx bark 10-30 parts, Mosla dianthera 10-30
Part, golden cypress 10-30 parts；
(3) by load weighted above-mentioned 5 taste Chinese medicine, plus 8-10 times is measured 50%-70% ethanol and is soaked 30 days, is stirred every 6 days
Once, filter, add borneol, turpentine oil to stir evenly, obtain final product.
2nd, clinical practice
1st, diagnostic criteria
Homeliness type psoriasis：Fash typically occurs in scalp, trunk, four limbs and stretches side, the papule for occurring redness on skin, table
There are thicker silvery white phosphorus bits in face, in babysbreath outward appearance, with pruitus.
Erythrodermic psoriasis：About more than the 70% of whole skin is red in diffusivity, kermesinus wellability skin damaged, surface
There are a large amount of chaff skin sample scurfs, with pruitus.
Pustular psoriasis：General whole body of warts, there is the intensive potential pimple of needle point size, is often accompanied by hyperpyrexia, closes
Section swells and ache, pruitus and general malaise, and routine blood test chemically examines visible leukocytosis, and after running sore is dry, furfur immediately, scurf takes off
Fall behind, have new running sore to occur again.
Psoriasis arthropathica：Common is wrist, finger and toes Minor articulus, and there are redness, pain, serious joint in joint
There are hydrops, juxtra-articular skin turgor limitation of activity, long joint stiffness, the destroyed feelings of visible joint under x-ray when serious in chamber
Condition, erythrocyte sedimentation rate is fast, and often occur together the general malaises such as heat, pruitus.
2nd, efficacy determination
Symptom all disappears to cure, and symptom mitigation is effective, and symptom is not changed in as invalid.
3. medication
(1) treatment group：The product of embodiment 1-4 is directly put outward in affected part on the skin, and 2-3 time on the 1st, continuous 3 weeks be a course for the treatment of.
(2) control group:Affected part is directly outer to put naftifine hydrochloride and ketoconazole cream on the skin, and 2-3 time on the 1st, continuous 3 weeks be a course for the treatment of.
4. result is applied
Antipsoriatics compositions of the present invention, once for treating and observe 164 patients or volunteer.Will be above-mentioned
The 4 kinds of embodiment samples for preparing, are respectively used to following 4 kinds of different types of patients or volunteer.A:Homeliness type psoriasis is (altogether
43, man 25, female 18, average age 30.8 years old), B:Erythrodermic psoriasis (totally 41, man 21, female 20, averagely
34.6 years old age), C:Pustular psoriasis：(totally 40, man 23, female 17, average age 35.2 years old), D:Arthropathica ox
Psoriasis (totally 40, man 21, female 19, average age 42.3 years old).Each embodiment sample and control sample are used for
The case of each type is no less than 5.The results are shown in Table 2.
Table 2 applies result table
As a result show：Curative effect is controlled than control sample to four type psoriasis treatment effects using the embodiment of the present invention
Fruit is slightly good, illustrates that pharmaceutical composition of the present invention has good curative effect to psoriasis, can reach the purpose for solving patient suffering.With
It is down several model cases：
Case 1：Wei ××, man, 29 years old, with homeliness type psoriasis cardinal symptom.Using (embodiment 1) of the invention, put on the skin outward
Affected part, 3 times a day, is used in conjunction 21, and psoriasis symptoms disappear substantially, recovery from illness, then with 7 days, recurrence is had no in March.
Case 2：××, female, 41 years old, hospital diagnosis were erythrodermic psoriasis.Using (embodiment 4) of the invention
100ml, plus appropriate hot water, bathing 1/ time is outer to apply 2 times, using psoriasis symptoms after 14 days be improved significantly, using 14 days
Afterwards, psoriasis symptoms disappear substantially, recovery from illness.
Case 3：Deep ××, man, 33 years old, hospital diagnosis were pustular psoriasis.Using of the invention (embodiment 2), outward
Put 2 times/day on the skin, be used in conjunction 14 days, psoriasis symptoms are greatly improved, generate heat, the symptom that comes to a head disappears, then with 14 days, all symptoms
Disappear, recovery from illness.
Case 4：All ××s, man, 46 years old, hospital diagnosis were psoriasis arthropathica.Using of the invention (embodiment 3), outward
Put 3 times/day on the skin, be used in conjunction 30, psoriasis symptoms disappear, recovery from illness.
Claims (10)
1. a kind of antipsoriatics compositions, it is characterised in that raw material is made up of the component of following weight portion：Rumex madaio
20-50 parts, kuh-seng 10-20 parts, operculate cleistocalyx bark 10-30 parts, Mosla dianthera 10-30 parts, golden cypress 10-30 parts, borneol 0.1-0.5 parts,
Turpentine oil 0.1-0.5 parts.
2. antipsoriatics compositions according to claim 1, it is characterised in that raw material is by following weight portion
Component is constituted：30 parts of Rumex madaio, 15 parts of kuh-seng, 20 parts of operculate cleistocalyx bark, 15 parts of Mosla dianthera, 15 parts of golden cypress, 0.2 part of borneol, turpentine
0.2 part of oil.
3. antipsoriatics compositions according to claim 1 and 2, it is characterised in that prepared by the composition
Into external preparation.
4. antipsoriatics compositions according to claim 1 and 2, it is characterised in that prepared by the composition
It is ointment, cream, paste, liniment, paint, tincture, gel into external preparation.
5. antipsoriatics compositions according to claim 1 and 2, it is characterised in that prepared by the composition
Into tincture.
6. a kind of antipsoriatics compositions as claimed in claim 1 or 2 are prepared into the preparation method of tincture, and it is special
Levy and be, comprise the following steps：
(1) fetch earth respectively rheum officinale, kuh-seng, operculate cleistocalyx bark, Mosla dianthera, golden cypress, clean, be dried；
(2) weigh by weight：Rumex madaio 20-50 parts, kuh-seng 10-20 parts, operculate cleistocalyx bark 10-30 parts, Mosla dianthera 10-30 parts,
Golden cypress 10-30 parts；
(3) by load weighted above-mentioned 5 taste Chinese medicine, plus 8-10 times is measured 50%-70% ethanol and is soaked 30 days, every stirring in 6 days once,
Filtration, adds borneol, turpentine oil to stir evenly, obtain final product.
7. a kind of antipsoriatics compositions as claimed in claim 6 are prepared into the preparation method of tincture, its feature
It is that the step (2) weighs by weight：30 parts of Rumex madaio, 15 parts of kuh-seng, 20 parts of operculate cleistocalyx bark, 15 parts of Mosla dianthera, golden cypress
15 parts.
8. a kind of antipsoriatics compositions as claimed in claim 6 are prepared into the preparation method of tincture, its feature
It is that the amount of the ethanol added by the step (3) is 9 times of amounts.
9. a kind of antipsoriatics compositions as claimed in claim 6 are prepared into the preparation method of tincture, its feature
It is that the concentration of ethanol added by the step (3) is 60%.
10. according to arbitrary described antipsoriatics compositions in claim 1-7, it is characterised in that the medicine
Purposes of the composition in treatment psoriasis medicine is prepared.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611066177.7A CN106619955A (en) | 2016-11-28 | 2016-11-28 | Medicinal composition for treating psoriasis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611066177.7A CN106619955A (en) | 2016-11-28 | 2016-11-28 | Medicinal composition for treating psoriasis and preparation method thereof |
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| CN106619955A true CN106619955A (en) | 2017-05-10 |
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| CN201611066177.7A Pending CN106619955A (en) | 2016-11-28 | 2016-11-28 | Medicinal composition for treating psoriasis and preparation method thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101199646A (en) * | 2007-12-18 | 2008-06-18 | 周松申 | External rubbing dose for treating psoriasis |
| CN101791385A (en) * | 2010-04-02 | 2010-08-04 | 程海东 | Medicine for treating psoriasis |
| CN103536823A (en) * | 2012-07-13 | 2014-01-29 | 葛学义 | External-use Chinese medicine tincture for treating psoriasis |
| CN104758425A (en) * | 2014-01-03 | 2015-07-08 | 陈炜 | Psoriasis treating external application traditional Chinese medicine ointment |
-
2016
- 2016-11-28 CN CN201611066177.7A patent/CN106619955A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101199646A (en) * | 2007-12-18 | 2008-06-18 | 周松申 | External rubbing dose for treating psoriasis |
| CN101791385A (en) * | 2010-04-02 | 2010-08-04 | 程海东 | Medicine for treating psoriasis |
| CN103536823A (en) * | 2012-07-13 | 2014-01-29 | 葛学义 | External-use Chinese medicine tincture for treating psoriasis |
| CN104758425A (en) * | 2014-01-03 | 2015-07-08 | 陈炜 | Psoriasis treating external application traditional Chinese medicine ointment |
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Application publication date: 20170510 |