CN106620158A - Medicine composition for treating psoriasis and preparation method thereof - Google Patents
Medicine composition for treating psoriasis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine composition for treating psoriasis and a preparation method thereof. The medicine composition is prepared from the following crude drugs in parts by weight: 10 to 40 parts of radix rumicis crispi, 10 to 20 parts of radix sophorae flavescentis, 10 to 30 parts of flos chrysanthemi indici, 10 to 20 parts of rhizoma smilacis glabrae, 10 to 20 parts of peel of cleistocalyx operculatus, 10 to 20 parts of mosla dianthera, 10 to 20 parts of cortex phellodendri, 0.1 to 0.5 part of borneol, and 0.1 to 0.5 part of turpentine. The medicine composition has the advantages that the formula compounding is reasonable, the therapy principle is clear, the synergistic action of the crude drugs is realized, and the functions of clearing heat and expelling damp, activating blood circulation and removing blood stasis, diminishing inflammation and detoxifying and the like are realized; the effect of treating the psoriasis is good, and the pain of a patient is effectively relieved.
Description
Technical field
The invention belongs to medicine field, it is related to one kind and treats psoriatic can have clearing heat and expelling damp, promoting blood circulation and removing blood stasis, anti-inflammatory
Pharmaceutical composition of detoxicating functions and preparation method thereof.
Background technology
Psoriasis, is commonly called as psoriasis, is a kind of dermatosis chronic disease of common chronic, obstinate, easy recurrence, it is characterized in that occurring
The papule for differing in size, erythema, surface is covered with the silvery white scales of skin that peel off, clear border, and the scales of skin that peel off occurs blood point after coming off.It is general to send out
Side and back are stretched in scalp, four limbs.Patient body health and physical and mental health are had a direct impact.Analyze by differential diagnosis in tcm, silver bits
Disease there are " blood is dry, blood-head, the deficiency of blood " as, and say from the angle of doctor trained in Western medicine, then be the various lifes due to keratinocyte hyperproliferation
Caused by changing metabolic disorder.At present, western medical treatment psoriasis mainly eliminates symptom, it is to avoid further deteriorate, it is impossible to effect a radical cure, and
Side effect is larger.And Chinese traditional treatment psoriasis is mainly nursed one's health blood, including enriching the blood to restore normal menstruation method, clearing heat and detoxicating
Method, activating blood and removing stasis Method etc., the recovery to the state of an illness is highly beneficial, can reach the purpose treated both principal and secondary aspect of disease.The psoriatic related system for the treatment of
Agent is there is not yet Rumex madaio, kuh-seng, mother chrysanthemum, smilax, operculate cleistocalyx bark, Mosla dianthera, golden cypress, borneol, turpentine fluid composition
Report.
(1) Rumex madaio, is the root of polygonaceae plant sheep hoof RumexjaponicusHoutt..【Nature and flavor and return through】It is pungent；It is bitter；Property
It is cool.Return lung；Spleen；Large intestine channel.【Function with cure mainly】It is clearing heat and detoxicating；Cooling blood and hemostasis；Eliminating stasis to resolve swelling；Defaecation；Desinsection.Main tuberculosis is coughed
Blood；Lung pain；Spit blood；Stasis of blood；Traumatic injury；Constipation；Mumps；Ulcerative carbuncle pyogenic infections；Scald；Mange；Eczema.
(2) kuh-seng, is the dry root of legume kuh-seng Sophora flavescens Ait..Chinese Pharmacopoeia 2015 editions
One is recorded：【Nature and flavor and return through】Hardship, trembles with fear.The thoughts of returning home, liver, stomach, large intestine, bladder warp.【Function with cure mainly】Heat-clearing and damp-drying drug, desinsection,
Diuresis.For hot dysentery, have blood in stool, jaundice renal shutdown, leukorrhea with reddish discharge, swelling of vulva pruritus vulvae, eczema, wet sore, pruitus, mange leprosy, outward
Control trichomonas vaginitis.
(3) mother chrysanthemum, is the dry capitulum of feverfew mother chrysanthemum Ghrysanthemum indicum L..Middle traditional Chinese medicines
Allusion quotation 2015 edition one is recorded：【Nature and flavor and return through】It is bitter, pungent, it is slightly cold.Return liver, the heart channel of Hang-Shaoyin.【Function with cure mainly】Clearing heat and detoxicating, purging intense heat is put down
Liver.For furunculosis carbuncle swells, red eye, swell pain, dizziness of having a headache.
(4) smilax, is the dry rhizome of liliaceous plant smilacis glabra Smilax glabra Roxb..Chinese Pharmacopoeia
2015 editions one is recorded：【Nature and flavor and return through】It is sweet, light, put down.Return liver, stomach.【Function with cure mainly】Removing toxic substances, dehumidifying is easing joint movement.
For the limbs contraction caused by syphilis and mercury poisoning, arthralgia and myalgia；Damp and hot stranguria with turbid discharge, under band, carbuncle swells, scrofula, mange.
(5) operculate cleistocalyx bark, is myrtle water father-in-law Cleistocalyx operculatus (Roxb.) Merr.et
The bark of Perry.【Nature and flavor】Bitter；It is pungent；It is cool in nature.【Function with cure mainly】It is clearing heat and detoxicating；Eliminating dampness；Desinsection.Main tinea pedis is wet rotten；It is wet
Rash；Mange；Scrotum carbuncle；Burn and scald.
(6) Mosla dianthera, is the herb of labiate flower thinning Ji Ning Mosla dianthera (Ham.) Maxim.【Property
Taste and return through】Taste is pungent；It is bitter；Slightly warm in nature.Return lung；Spleen；Stomach【Function with cure mainly】Deliver driving away summer heat；Dampness removing is with；Detumescence hemostasis；Dissipate
Wind is antipruritic.Cure mainly anemofrigid cold；Yin summer-heat syndrome is had a headache；Nausea；Gastral cavity pain；Dysentery characterized by white mucous stool；Oedema；Bleeding from five sense organs or subcutaneous tissue；Hemorrhoid blood；Boil；Pruritus vulvae；Eczema；Miliaria
Poison；Traumatism and bleeding；Snake bite and insect sting.
(7) golden cypress, is the dry bark of rutaceae wampee Phellodendron chinense Schneid..
Chinese Pharmacopoeia 2015 edition one is recorded：【Nature and flavor and return through】Hardship, trembles with fear.Return ' kidney, bladder warp.【Function with cure mainly】Heat-clearing and damp-drying drug, rushes down
Fire is except steaming, detoxification sore treatment.For damp-heat dysentery, jaundice urine is red, under band pruritus vulvae, puckery pain of heat gonorrhea, tinea pedis impotence is knitted, and hectic fever due to yin labor heat is stolen
Sweat, seminal emission, sore swollen toxin, eczema wet sore.
(8) borneol, is divided to BORNEOLUM SYNTHETICUM and the class of L-Borneol two.BORNEOLUM SYNTHETICUM is with turpentine oil, camphor etc. as raw material Jing chemical methodes
The borneol of synthesis；L-Borneol for composite family Blumea balsamifera platymiscium Balsamiferou Blumea Herb the steam distillation of fresh leaf Jing, cooling obtained by crystallization, also known as Chinese mugwort
Powder or sheeting.【Nature and flavor】Pungent, hardship, is slightly cold.【Return through】The thoughts of returning home, spleen, lung channel.【Function with cure mainly】Inducing resuscitation of having one's ideas straightened out, clearing away heat to and alleviating pain.With
In pyreticosis coma, faint from fear, apoplexy coma due to blocking of the respiratory system, bstruction of the circulation of vital energy is fainted cruelly, middle evil is gone into a coma, hot eyes, aphtha, abscess of throat, duct is suppurated.
(9) turpentine oil, is the oleoresin oozed out in Pinaceae Pinus several plants, Jing distillations or extracts the volatile oil for obtaining.
【Function with cure mainly】It is promoting blood circulation and removing obstruction in channels；Swelling and pain relieving.Main joint swells and ache；Courbature；Traumatic injury.
The content of the invention
It is an object of the invention to provide one kind treats psoriasis good effect, instant effect, can reach and treat both principal and secondary aspect of disease and be difficult more afterwards
External-use tincture of recurrence and preparation method thereof.
The psoriatic pharmaceutical composition of present invention treatment is on the basis of traditional Chinese medicine traditional theory, with reference to medication Jing among the people
Test, be formulated with modern scientific theory.Rigorous with prescription, the few power of medicine specially, has good curative effect to psoriasis, effectively solution
The certainly pain of patient.
The technical solution adopted in the present invention is as follows：
One kind treats psoriatic pharmaceutical composition, is made up of the component of following weight portion：Rumex madaio 10-40 parts, kuh-seng
10-20 parts, mother chrysanthemum 10-30 parts, smilax 10-20 parts, operculate cleistocalyx bark 10-20 parts, Mosla dianthera 10-20 parts, golden cypress 10-20
Part, borneol 0.1-0.5 parts, turpentine oil 0.1-0.5 parts.Preferably, the psoriatic pharmaceutical composition of described treatment, by following
The component composition of weight portion：25 parts of Rumex madaio, 15 parts of kuh-seng, 20 parts of mother chrysanthemum, 15 parts of smilax, 15 parts of operculate cleistocalyx bark, small fish are celestial
15 parts of grass, 15 parts of golden cypress, 0.2 part of borneol, 0.2 part of turpentine oil.
It is above-described to treat psoriatic pharmaceutical composition, any exterior-applied formulation allowed on medicine can be prepared into, such as：
Ointment, cream, paste, liniment, paint, tincture, gel etc., are preferably made tincture.
The psoriatic pharmaceutical composition of above-mentioned treatment is prepared into the preparation method of tincture, comprises the following steps：
(1) fetch earth respectively rheum officinale, kuh-seng, mother chrysanthemum, smilax, operculate cleistocalyx bark, Mosla dianthera, golden cypress, clean, be dried；
(2) weigh by weight：Rumex madaio 10-40 parts, kuh-seng 10-20 parts, mother chrysanthemum 10-30 parts, smilax 10-20
Part, operculate cleistocalyx bark 10-20 parts, Mosla dianthera 10-20 parts, golden cypress 10-20 parts；
(3) by load weighted above-mentioned 7 taste Chinese medicine, plus 8-10 times is measured 50%-70% ethanol and is soaked 30 days, is stirred every 6 days
Once, filter, add borneol, turpentine oil to stir evenly, obtain final product.
Further, the concentration of the ethanol is preferably 60% under step (3) item, and the addition of the ethanol is preferably 9
Measure again.
Rumex madaio is monarch drug in a prescription in side in the present invention, with clearing heat and detoxicating, cooling blood and hemostasis, eliminating stasis to resolve swelling, defaecation, desinsection it
Work(, cures mainly tuberculosis hemoptysis, and lung pain is spitted blood, and stasis of blood, traumatic injury, constipation, mumps, ulcerative carbuncle pyogenic infections are scalded；Mange；
Eczema.Kuh-seng, mother chrysanthemum, smilax, operculate cleistocalyx bark, Mosla dianthera, golden cypress are respectively provided with as the antipruritic work(of heat-clearing and damp-drying drug, desinsection, are
Ministerial drug in side.Borneol is adjutant in side；Turpentine oil is to make medicine in side.Prescription compatibility of medicines of the present invention is reasonable, special treatment, each herbal medicine
Synergy, promoting blood circulation and removing blood stasis with clearing heat and expelling damp, the function such as eliminating inflammation and expelling toxin, treatment psoriasis good effect, instant effect have sample
The simultaneous effect controlled, can reach the target of difficulty in relapse after healing.
Specific embodiment
With reference to specific embodiment, the invention will be further described, but do not limit the scope of the invention and apply
Scope：
First, the preparation of tincture
1. experimental design：
This test is prepared into respectively tincture with 4 embodiments, and design parameter refers to table 1.
The tincture embodiment preparation parameter table of table 1
2. operating procedure：
(1) fetch earth respectively rheum officinale, kuh-seng, mother chrysanthemum, smilax, operculate cleistocalyx bark, Mosla dianthera, golden cypress, clean, be dried；
(2) weigh by weight：Rumex madaio 10-40 parts, kuh-seng 10-20 parts, mother chrysanthemum 10-30 parts, smilax 10-20
Part, operculate cleistocalyx bark 10-20 parts, Mosla dianthera 10-20 parts, golden cypress 10-20 parts；
(3) by load weighted above-mentioned 7 taste Chinese medicine, plus 8-10 times is measured 50%-70% ethanol and is soaked 30 days, is stirred every 6 days
Once, filter, add borneol, turpentine oil to stir evenly, obtain final product.
2nd, clinical practice
1st, diagnostic criteria
Homeliness type psoriasis：Fash typically occurs in scalp, trunk, four limbs and stretches side, the papule for occurring redness on skin, table
There are thicker silvery white phosphorus bits in face, in babysbreath outward appearance, with pruitus.
Erythrodermic psoriasis：About more than the 70% of whole skin is red in diffusivity, kermesinus wellability skin damaged, surface
There are a large amount of chaff skin sample scurfs, with pruitus.
Pustular psoriasis：General whole body of warts, there is the intensive potential pimple of needle point size, is often accompanied by hyperpyrexia, closes
Section swells and ache, pruitus and general malaise, and routine blood test chemically examines visible leukocytosis, and after running sore is dry, furfur immediately, scurf takes off
Fall behind, have new running sore to occur again.
Psoriasis arthropathica：Common is wrist, finger and toes Minor articulus, and there are redness, pain, serious joint in joint
There are hydrops, juxtra-articular skin turgor limitation of activity, long joint stiffness, the destroyed feelings of visible joint under x-ray when serious in chamber
Condition, erythrocyte sedimentation rate is fast, and often occur together the general malaises such as heat, pruitus.
2nd, efficacy determination
Symptom all disappears to cure, and symptom mitigation is effective, and symptom is not changed in as invalid.
3. medication
(1) treatment group：The product of embodiment 1-4 is directly put outward in affected part on the skin, and 2-3 time on the 1st, continuous 3 weeks be a course for the treatment of.
(2) control group:Affected part is directly outer to put naftifine hydrochloride and ketoconazole cream on the skin, and 2-3 time on the 1st, continuous 3 weeks be a course for the treatment of.
4th, result is applied
The present invention psoriatic pharmaceutical composition for the treatment of, once for treating and observe 166 patients or volunteer.Will be above-mentioned
The 4 kinds of embodiment samples for preparing, are respectively used to following 4 kinds of different types of patients or volunteer.A:Homeliness type psoriasis is (altogether
54, man 30, female 24, average age 31.5 years old), B:Erythrodermic psoriasis (totally 21, man 12, female 9, averagely
32.5 years old age), C:Pustular psoriasis：(totally 20, man 12, female 8, average age 37.1 years old), D:Arthropathica ox
Psoriasis (totally 16, man 10, female 6, average age 44.2 years old).Each embodiment sample and control sample are used for upper every
A type of case is no less than 5.The results are shown in Table 2.
Table 2 applies result table
As a result show：Curative effect is controlled than control sample to four type psoriasis treatment effects using the embodiment of the present invention
Fruit is slightly good, illustrates that pharmaceutical composition of the present invention has good curative effect to psoriasis, can reach the purpose for solving patient suffering.With
It is down several model cases：
Case 1：Hu ××, man, 33 years old, hospital diagnosis were erythrodermic psoriasis.Using (embodiment 1) of the invention
100ml, plus appropriate hot water, bathing 1/ time is outer to apply 2 times, using psoriasis symptoms after 14 days be improved significantly, using 14 days
Afterwards, psoriasis symptoms disappear substantially, recovery from illness.
Case 2：Wei ××, man, 35 years old, hospital diagnosis were pustular psoriasis.Using of the invention (embodiment 2), outward
Put 3 times/day on the skin, be used in conjunction 15 days, psoriasis symptoms are greatly improved, generate heat, the symptom that comes to a head disappears, then with 15 days, all symptoms
Disappear, recovery from illness.
Case 3：Wei ××, female, 47 years old, hospital diagnosis were psoriasis arthropathica.Using of the invention (embodiment 4), outward
Put 2 times/day on the skin, be used in conjunction 28, psoriasis symptoms disappear, recovery from illness.
Case 4：Wei ××, man, 27 years old, with homeliness type psoriasis cardinal symptom.Using (embodiment 3) of the invention, put on the skin outward
Affected part, 3 times a day, is used in conjunction 21, and psoriasis symptoms disappear substantially, recovery from illness, then with 7 days, recurrence is had no in March.
Claims (10)
1. one kind treats psoriatic pharmaceutical composition, it is characterised in that raw material is made up of the component of following weight portion：Rumex madaio
10-40 parts, kuh-seng 10-20 parts, mother chrysanthemum 10-30 parts, smilax 10-20 parts, operculate cleistocalyx bark 10-20 parts, Mosla dianthera 10-20
Part, golden cypress 10-20 parts, borneol 0.1-0.5 parts, turpentine oil 0.1-0.5 parts.
2. it is according to claim 1 to treat psoriatic pharmaceutical composition, it is characterised in that raw material is by following weight portion
Component is constituted：25 parts of Rumex madaio, 15 parts of kuh-seng, 20 parts of mother chrysanthemum, 15 parts of smilax, 15 parts of operculate cleistocalyx bark, 15 parts of Mosla dianthera, Huang
15 parts of cypress, 0.2 part of borneol, 0.2 part of turpentine oil.
3. it is according to claim 1 and 2 to treat psoriatic pharmaceutical composition, it is characterised in that prepared by the composition
Into external preparation.
4. it is according to claim 1 and 2 to treat psoriatic pharmaceutical composition, it is characterised in that prepared by the composition
It is ointment, cream, paste, liniment, paint, tincture, gel into external preparation.
5. it is according to claim 1 and 2 to treat psoriatic pharmaceutical composition, it is characterised in that prepared by the composition
Into tincture.
6. it is a kind of to treat the preparation method that psoriatic pharmaceutical composition is prepared into tincture as claimed in claim 5, its feature
It is to comprise the following steps：
(1) fetch earth respectively rheum officinale, kuh-seng, mother chrysanthemum, smilax, operculate cleistocalyx bark, Mosla dianthera, golden cypress, clean, be dried；
(2) weigh by weight：Rumex madaio 10-40 parts, kuh-seng 10-20 parts, mother chrysanthemum 10-30 parts, smilax 10-20 parts, water
Father-in-law's skin 10-20 parts, Mosla dianthera 10-20 parts, golden cypress 10-20 parts；
(3) by load weighted above-mentioned 7 taste Chinese medicine, plus 8-10 times is measured 50%-70% ethanol and is soaked 30 days, every stirring in 6 days once,
Filtration, adds borneol, turpentine oil to stir evenly, obtain final product.
7. it is a kind of to treat the preparation method that psoriatic pharmaceutical composition is prepared into tincture as claimed in claim 6, its feature
It is that the step (2) weighs by weight：25 parts of Rumex madaio, 15 parts of kuh-seng, 20 parts of mother chrysanthemum, 15 parts of smilax, operculate cleistocalyx bark
15 parts, 15 parts of Mosla dianthera, 15 parts of golden cypress.
8. it is a kind of to treat the preparation method that psoriatic pharmaceutical composition is prepared into tincture as claimed in claim 6, its feature
It is that the amount of the ethanol added by the step (3) is 9 times of amounts.
9. it is a kind of to treat the preparation method that psoriatic pharmaceutical composition is prepared into tincture as claimed in claim 6, its feature
It is that the concentration of ethanol added by the step (3) is 60%.
10. according to the psoriatic pharmaceutical composition of arbitrary treatment in claim 1-7, it is characterised in that the medicine group
Purposes of the compound in treatment psoriasis are prepared.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201611064596.7A CN106620158A (en) | 2016-11-28 | 2016-11-28 | Medicine composition for treating psoriasis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201611064596.7A CN106620158A (en) | 2016-11-28 | 2016-11-28 | Medicine composition for treating psoriasis and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115040600A (en) * | 2022-06-27 | 2022-09-13 | 天津市中医药研究院附属医院 | Traditional Chinese medicine composition for treating scalp psoriasis |
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2016
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115040600A (en) * | 2022-06-27 | 2022-09-13 | 天津市中医药研究院附属医院 | Traditional Chinese medicine composition for treating scalp psoriasis |
| CN115040600B (en) * | 2022-06-27 | 2023-11-24 | 天津市中医药研究院附属医院 | Traditional Chinese medicine composition for treating scalp psoriasis |
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