CN104800302A - Externally applied plaster for treating thromboangiitis obliterans and preparation method - Google Patents
Externally applied plaster for treating thromboangiitis obliterans and preparation method Download PDFInfo
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Abstract
The invention discloses an externally applied plaster for treating thromboangiitis obliterans and a preparation method. The externally applied plaster is prepared from the following traditional Chinese medicine raw materials according to weight proportion: 30-80 g of carthamus tinctorius, 50-120 g of caulis impatientis, 2-12 g of rosin, 2-8 g of leeches, 2-6 g of dried bodies of scorpion, 20-40 g of pseudo-ginseng, 30-60 g of cortex moutan, 50-100 g of caulis spatholobi, 50-100 g of radix paeoniae rubra and 20-50 g of radix salviae miltiorrhizae. The externally applied plaster prepared by adopting the preparation method has the effects of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, warming channel, expelling cold, is convenient to use, obvious therapeutic effect, and capable of enhancing thromboangiitis obliterans elastic extension and shrinkage capacity and achieves the purpose of treating thromboangiitis obliterans.
Description
Technical field
The present invention relates to thromboangiitis obliterans field, particularly provide heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, dispelling cold by warming the meridian, treatment significantly, strengthen thromboangiitis obliterans elastic dilatation, the treatment thromboangiitis obliterans externally applied ointment of contractility and preparation method.
Background technology
Thromboangiitis obliterans is in a kind of rare chronic recurrent, the segmental diseases associated with inflammation of small artery and vein, and lower limb are common.Show as suffering limb ischemia, pain, intermittent claudication, pulsation of foot dorsal artery weaken or disappear and migrans Superficial phlebitis, severe patient has acra ulcer and necrosis.Primary disease is more common in person between twenty and fifty, is apt to occur in lower limb.Suffering limb presents momentary or persistence is pale, cyanosis, have scorching hot and twinge, and when sick limb is sagging, color of the leather reddens, and bleaches during upper act, and then toes are numb, and Calf muscle pain, excites during walking, disappears during rest; Often there is superficial phlebitis and edema in calf.Find during inspection that pulsation of foot dorsal artery weakens or disappears.Along with PD can there is intermittent claudication and Raynaud phenomenon, night, the pain increased, toes sharp ache, skin cyanosis, and then toe-end ulcer or gangrene and turn black, spread to proximal part gradually.Current western medicine is the dextran intravenous drip of 5000 ~ 20000 with dextran-40 molecular weight.Also has oral prednisone or intravenous drip hydrocortisone oral every day.Medicine for external use has rehabilitation new, and these medicine side effect are large, easily recur, and therapeutic effect is remarkable, this just need the externally applied ointment of pure Chinese medicine composition, safe and effective, without any side effects, formula rationally, instant effect to be to meet clinical practice.
Summary of the invention
For the deficiencies in the prior art, object of the present invention to provide exactly a kind of easy to use, economical, safe and effective, without any side effects, formula is reasonable, effect directly treats thromboangiitis obliterans externally applied ointment and preparation method.
To achieve these goals, the invention provides following technical scheme:
Treatment thromboangiitis obliterans externally applied ointment of the present invention, it is made up of following raw material of Chinese medicine weight proportion: Flos Carthami 30 ~ 80g, Herba speranskiae tuberculatae 50 ~ 120g, Colophonium 2 ~ 12g, Hirudo 2 ~ 8g, Scorpio 2 ~ 6g, Radix Notoginseng 20 ~ 40g, Cortex Moutan 30 ~ 60g, Caulis Spatholobi 50 ~ 100g, Radix Paeoniae Rubra 50 ~ 100g, Radix Salviae Miltiorrhizae 20 ~ 50g.
Treatment thromboangiitis obliterans externally applied ointment of the present invention, more preferably raw material of Chinese medicine weight proportion is made: Flos Carthami 60g, Herba speranskiae tuberculatae 100g, Colophonium 8g, Hirudo 6g, Scorpio 4g, Radix Notoginseng 40g, Cortex Moutan 50g, Caulis Spatholobi 60g, Radix Paeoniae Rubra 100g, Radix Salviae Miltiorrhizae 40g.
Medical material used in the present invention has following characteristic:
Flos Carthami: Flos Carthami, (Classification system: Carthamus tinctorius L.), another name: red indigo plant flower, thorn Flos Carthami, Compositae, Flos Carthami platymiscium, dry tubular flower, orange red, floral tube is carefully narrow, tip 5 splits, sliver is narrow linear, and flower pesticide is yellow, is unified into pipe, exceed outside sliver, its central authorities have stigma to expose.The special fragrance of tool, mildly bitter flavor.To spend, length of a film, color are scarlet, the soft person of matter is good.Nature and flavor-Xin Wen, attending effectiveness: promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving
Herba speranskiae tuberculatae: Herba speranskiae tuberculatae (formal name used at school: Phryma leptostachya L. subsp.asiatica (Hara) Kitamura) has another name called distiller’s yeast grass, Staggergrass etc.Herba speranskiae tuberculatae (formal name used at school: Phryma leptostachya L. subsp.asiatica (Hara) Kitarnura) has another name called distiller’s yeast grass, Staggergrass etc.Nature and flavor-Gan, pungent, warm, attending effectiveness: soothing the channels and quicking the network vessels, blood circulation promoting and blood stasis dispelling, diuresis removing toxic substances, deep effect of stimulating the menstrual flow.
Colophonium: Colophonium take pine resin as raw material, the non-volatile natural resin obtained by different processing modes.Solid, transparent, water insoluble, be dissolved in ethanol, matter is hard and crisp, faint yellow or brown." herbal classic " nature and flavor-bitter in the mouth, temperature, attending effectiveness: dispeiling pathogenic wind and removing dampness, granulation promoting pain relieving, is applicable to carbuncle furuncle infections, eczema, traumatic hemorrhage.
Hirudo: Hirudo, Chinese medicine name.For the drying of Hirudinidae animal whitmania Whitm.ania Pigra Whitman, Hirudo Hirudonipponica Whitman or Folium Salicis Babylonicae Hirudo Whitmania acranutata Whitman is all.Nature and flavor-salty, bitter, flat.Return Liver Channel, attending effectiveness: for blood stasis amenorrhea, addiction abdominal mass mass in the abdomen, apoplectic hemiplegia, injury from falling down.
Scorpio: Scorpio, Chinese medicine name.For the dry body of Buthidae animal Scorpio Buthus martensii Karsch.This product cephalothorax and preabdomen are flat oblong, and postabdomen is shape of tail, and shrinkage bends, and complete person's body is about 6cm.Nature and flavor-Xin Ping, attending effectiveness: endogenous wind stopping spasmolytic, removing obstruction in the collateral to relieve pain, dispersing pathogen accumulation.
Radix Notoginseng: Radix Notoginseng, Chinese medicine name.For the dry root welding technology of panax araliaceae plant Panax notoginseng (Burk.) F.H.Chen.Woody part is micro-radially to be arranged, feeble QI, bitter in the mouth Hui Tian.Nature and flavor-Gan, micro-hardship, temperature.Attending effectiveness: dissipating blood stasis stops blooding, subduing swelling and relieving pain.
Cortex Moutan: Cortex Moutan, Chinese medicine name.For the dry root bark of ranunculaceae peony.Nature and flavor-hardship, pungent, be slightly cold, attending effectiveness: thermal man's nutrient blood, maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, falls and flutters the pain of injury, carbuncle sore tumefacting virus.
Caulis Spatholobi: be the another name of the various plants such as Schisandraceae, Sargentodoxaceae, Cuscutaceae, Papilionaceae, evergreen woody climber, without hair, shoot dirty-green, base portion Su Cunyou number piece triangular shape perula.The dark violet green of stem, has canescence hole skin, main root yellowish-brown, cross section mulberry.Nature and flavor-Wen; Bitter, sweet; Return Liver Channel, attending effectiveness: invigorate blood circulation, enrich blood, dredging collateral, for blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.
Radix Paeoniae Rubra: be the dry root of ranunculaceae plant Radix Paeoniae Rubra or river Radix Paeoniae Rubra.Spring, Qiu Erji excavate, and removing rhizome, fibrous root and silt, dry.Hardship, is slightly cold.Return Liver Channel.There is clearing away heat and cooling blood, effect of blood circulation promoting and blood stasis dispelling.
Radix Salviae Miltiorrhizae: Radix Salviae Miltiorrhizae, Chinese medicine name.For the dry root welding technology of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..Spring, Qiu Erji excavate, removing silt, dry.Whole nation most area has distribution.Bitter in the mouth, be slightly cold, GUIXIN, Liver Channel, have blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, and clear away heart-fire relieving restlessness, effect of removing heat from blood eliminating carbuncle.For obstruction of qi in the chest and cardialgia, gastral cavity abdomen hypochondriac pain, abdominal mass abdominal mass is gathered, pyretic arthralgia pain, dysphoria and insomnia, menoxenia, and dysmenorrhea amenorrhea, skin infection swells and ache.
The present invention also provides the preparation method of above-mentioned externally applied ointment, and the method that the people usually adopted in the art know comprises the steps
1) each raw material weight proportioning of following Chinese medicine is taken: Flos Carthami 30 ~ 80g, Herba speranskiae tuberculatae 50 ~ 120g, Colophonium 2 ~ 12g, Hirudo 2 ~ 8g, Scorpio 2 ~ 6g, Radix Notoginseng 20 ~ 40g, Cortex Moutan 30 ~ 60g, Caulis Spatholobi 50 ~ 100g, Radix Paeoniae Rubra 50 ~ 100g, Radix Salviae Miltiorrhizae 20 ~ 50g;
2) the above-mentioned selected each raw material of Chinese medicine is put into pot low baking temperature parching to brown, is placed in after cooling in container, add medicine gross mass 3-5 Oleum Sesami sealing doubly and soak, then medicine and Oleum Sesami are fried into ?color, filter for subsequent use;
3) the medicine oil filtered out is got put into pot in right amount and decoct heat, more evenly put into Plumbum preparatium, be fried boiling to black plaster shape with fire;
4) Jian ? plaster before burning things which may cause a fire disaster cools completely, the Borneolum Syntheticum being ground into powder to be added cooling in cream and obtains externally applied ointment removing.
How using method: early, middle and late each external application 1 time every day, 30 days courses for the treatment of, took effect at 7 days after the drug of topical application, and 1 ~ 3 course for the treatment of cures.This Chinese medicine plaster feature to make patient fully recover, instant effect, and effective, toxic and side effects is little, plays the effect for the treatment of both the principal and secondary aspects of a disease, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, dispelling cold by warming the meridian, and without recurrence, cost is low, and clinic is applied.
Beneficial effect
The effect that the present invention treats thromboangiitis obliterans externally applied ointment is set forth further below by way of clinical observation on the therapeutic effect.
1, physical data
Accept out-patient for medical treatment and have 100 examples altogether, 35 ~ 70 years old age, more than the course of disease 5 ~ December.
2, criterion of therapeutical effect
Formulate with reference to " Chinese medicine Clinical Researches of New Drugs guideline ".
Cure: blood vessel dilating, alleviating vascular spasm, promote that limbs Doppler flow mapping is set up, thus improve promoting extremities blood circulation;
Effective: blood vessel dilating, alleviating vascular spasm;
Take a turn for the better: the viscid degree reducing blood, strengthen and adjust the immunologic function of body;
Invalid: without obviously changing after treatment, or after treatment, symptom and Signs increase the weight of.
3, therapeutic outcome, sees the following form:
Detailed description of the invention
Embodiment 1
Flos Carthami 60g, Herba speranskiae tuberculatae 100g, Colophonium 8g, Hirudo 6g, Scorpio 4g, Radix Notoginseng 40g, Cortex Moutan 50g, Caulis Spatholobi 60g, Radix Paeoniae Rubra 100g, Radix Salviae Miltiorrhizae 40g.
1) the above-mentioned selected each raw material of Chinese medicine is put into pot low baking temperature parching to brown, is placed in after cooling in container, add medicine gross mass 3-5 Oleum Sesami sealing doubly and soak, then medicine and Oleum Sesami are fried into ?color, filter for subsequent use;
2) the medicine oil filtered out is got put into pot in right amount and decoct heat, more evenly put into Plumbum preparatium, be fried boiling to black plaster shape with fire;
3) Jian ? plaster before burning things which may cause a fire disaster cools completely, the Borneolum Syntheticum being ground into powder to be added cooling in cream and obtains externally applied ointment removing.
How using method: early, middle and late each external application 1 time every day, 30 days courses for the treatment of, took effect at 7 days after the drug of topical application, and 1 ~ 3 course for the treatment of cures.
Embodiment 2
Flos Carthami 30g, Herba speranskiae tuberculatae 50g, Colophonium 2.2g, Hirudo 2g, Scorpio 1.8g, Radix Notoginseng 20g, Cortex Moutan 30g, Caulis Spatholobi 50g, Radix Paeoniae Rubra 50g, Radix Salviae Miltiorrhizae 20g.
Preparation method is the same manner as in Example 1.
Embodiment 3
Flos Carthami 80g, Herba speranskiae tuberculatae 120g, Colophonium 5.5g, Hirudo 5g, Scorpio 4.8g, Radix Notoginseng 40g, Cortex Moutan 60g, Caulis Spatholobi 100g, Radix Paeoniae Rubra 100g, Radix Salviae Miltiorrhizae 50g.
Preparation method is the same manner as in Example 1.
Model case
Case one poplar, male, 45 years old, patient in May, 2012 conscious right foot send out cool, numb, pain is not obvious, the hospital then on high bridge town, Yin state in 2010, and acatalepsia is true, does not go any treatment.Rear 4th toe, also there is same symptom in the 5th toe, pain increases the weight of, and night, pain was obvious, and impact is had a rest, and travel distance is about the conscious calf of 10-20 rice and suppresses swollen, remission after having a rest.Then go to a doctor in First Hospital in June, 2012, be diagnosed as right lower extremity thromboangiitis obliterans, hospitalization more than 10 sky, giving quiet Radix Salviae Miltiorrhizae and expand blood vessel class medicine, (concrete medication is not quite clear), there is right foot Isosorbide-5-Nitrae in weak effect, 5 toe blackouts.Then go to a doctor in the People's Hospital of city 113 in October, 2013, carry out two angiography of lower extremity arteries and tremulous pulse CT examination, above-mentioned diagnosis is clear and definite, and gives dead point expansion blood vessel class medicine (concrete medication is not quite clear) treatment 9 days, DeGrain, 2nd, also there is blackout in 3 toes and instep, since idiopathy, spiritual diet still can, sleep is general, and defecation is normal.For asking further diagnosis and treatment, external application plaster of the present invention, 15 days, patient body sign was clearly better, and continuous external application is 1 course for the treatment of completely, cures completely, does not recur so far.
Case two Zhang, male, 50 years old, within 2013, patient admits checked that color-Doppler ultrasound finds, right upper extremity tremulous pulse, ulnar artery, brachial artery vascular occlusion.Clarify a diagnosis " thromboangiitis obliterans III phase one-level ".According to the concrete state of an illness of patient, determine external application treatment thromboangiitis obliterans of the present invention externally applied ointment, after 7 days, the conscious skin temperature of patient starts to raise, and pain symptom alleviates, and limbs start effectively.Continuous external application 7 days again, after half course for the treatment of, skin temperature obviously raises, and night, pain disappeared.Right hand middle finger ulcer necrosis punishment secretion obviously reduces, visible fresh granulation tissue growth.Adhere to that external application amounts to 2 courses for the treatment of.Patient's skin of upper extremity temperature is substantially identical, and ulcer heals substantially.Check color-Doppler ultrasound of going to the hospital afterwards shows: right upper extremity tremulous pulse, brachial artery have a large amount of Doppler flow mapping blood vessel to set up, and patient cures at present completely.
Claims (3)
1. a treatment thromboangiitis obliterans externally applied ointment, it is characterized in that, it is made up of following raw material of Chinese medicine weight proportion: Flos Carthami 30 ~ 80g, Herba speranskiae tuberculatae 50 ~ 120g, Colophonium 2 ~ 12g, Hirudo 2 ~ 8g, Scorpio 2 ~ 6g, Radix Notoginseng 20 ~ 40g, Cortex Moutan 30 ~ 60g, Caulis Spatholobi 50 ~ 100g, Radix Paeoniae Rubra 50 ~ 100g, Radix Salviae Miltiorrhizae 20 ~ 50g.
2. treatment thromboangiitis obliterans externally applied ointment according to claim 1, it is characterized in that, it is made up of following raw material of Chinese medicine weight proportion: Flos Carthami 60g, Herba speranskiae tuberculatae 100g, Colophonium 8g, Hirudo 6g, Scorpio 4g, Radix Notoginseng 40g, Cortex Moutan 50g, Caulis Spatholobi 60g, Radix Paeoniae Rubra 100g, Radix Salviae Miltiorrhizae 40g.
3. the preparation method for the treatment of thromboangiitis obliterans externally applied ointment according to claim 1, it is characterized in that, the method comprises the steps:
1) each raw material weight proportioning of following Chinese medicine is taken: Flos Carthami 30 ~ 80g, Herba speranskiae tuberculatae 50 ~ 120g, Colophonium 2 ~ 12g, Hirudo 2 ~ 8g, Scorpio 2 ~ 6g, Radix Notoginseng 20 ~ 40g, Cortex Moutan 30 ~ 60g, Caulis Spatholobi 50 ~ 100g, Radix Paeoniae Rubra 50 ~ 100g, Radix Salviae Miltiorrhizae 20 ~ 50g;
2) the above-mentioned selected each raw material of Chinese medicine is put into pot low baking temperature parching to brown, be placed in after cooling in container, add medicine gross mass 3-5 Oleum Sesami sealing doubly and soak, then medicine is fried into black with Oleum Sesami, filter for subsequent use;
3) the medicine oil filtered out is got put into pot in right amount and decoct heat, more evenly put into Plumbum preparatium, be fried boiling to black plaster shape with fire;
4) decocting black plaster removing to add cooling in cream and obtains externally applied ointment by the Borneolum Syntheticum being ground into powder before burning things which may cause a fire disaster cools completely.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106138323A (en) * | 2016-08-14 | 2016-11-23 | 鄢海军 | A kind of scald external patch specially controlling scald |
| CN113827557A (en) * | 2021-11-18 | 2021-12-24 | 河南中医药大学 | Traditional Chinese medicine ointment for preventing and treating radiodermatitis |
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| CN1413722A (en) * | 2002-10-25 | 2003-04-30 | 岳喜杰 | Chinese patent drug for treating thrombus obliterating angiitis |
| CN101269155A (en) * | 2008-03-28 | 2008-09-24 | 丁昌荣 | Plaster for treating angitis, phlebitis rankle and preparation method |
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2015
- 2015-03-30 CN CN201510154454.9A patent/CN104800302A/en active Pending
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| CN1413722A (en) * | 2002-10-25 | 2003-04-30 | 岳喜杰 | Chinese patent drug for treating thrombus obliterating angiitis |
| CN101269155A (en) * | 2008-03-28 | 2008-09-24 | 丁昌荣 | Plaster for treating angitis, phlebitis rankle and preparation method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106138323A (en) * | 2016-08-14 | 2016-11-23 | 鄢海军 | A kind of scald external patch specially controlling scald |
| CN113827557A (en) * | 2021-11-18 | 2021-12-24 | 河南中医药大学 | Traditional Chinese medicine ointment for preventing and treating radiodermatitis |
| CN113827557B (en) * | 2021-11-18 | 2024-01-26 | 河南中医药大学 | Traditional Chinese medicine ointment for preventing and treating radiodermatitis |
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Application publication date: 20150729 |