CN111991465A - A pharmaceutical composition for treating psoriasis and preparation method thereof - Google Patents
A pharmaceutical composition for treating psoriasis and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the field of medicines, and discloses a pharmaceutical composition for treating psoriasis and a preparation method thereof, wherein the pharmaceutical composition comprises the following raw materials: cortex Dictamni Radicis, cortex Picrasmae, radix Tripterygii Wilfordii, cortex Phellodendri, Oryza Glutinosa, herba Polygoni Hydropiperis, radix Rumicis, Indigofera tinctoria, caulis et folium Gaultheriae Yunnanensis, and water; the pharmaceutical composition has the advantages of 95 percent of cure rate for psoriasis patients, 100 percent of effective rate for treatment, high curative effect, no toxic or side effect, effectiveness for mild patients on the same day, and recovery in 10 days; the serious patient is effective on the same day, and can be cured in 25-28 days; and after treatment, the skin has no black spots outside the skin, no scars inside the skin and no relapse; the preparation method is simple and easy to operate and implement.
Description
Technical Field
The invention relates to the field of medicines, in particular to a pharmaceutical composition for treating psoriasis and a preparation method thereof.
Background
Psoriasis vulgaris, commonly known as psoriasis, is a common chronic and easily relapsing inflammatory skin disease with characteristic skin lesions. The early stage is inflammatory red papule, about millet to mung bean in size, and then gradually expands or fuses into brownish red plaque with clear boundary, inflammatory red halo around the plaque, obvious substrate infiltration, and multiple layers of dry grey-white or silvery-white scales on the surface. The surface scale is scraped off slightly, and a layer of pale red and bright semitransparent film is gradually exposed, which is called the film phenomenon. When the film is scraped off, a small bleeding spot appears, which is called a spot bleeding phenomenon. White scales, shiny films and punctate bleeding are important features for diagnosing psoriasis, called triple features. Psoriasis vulgaris lesions can be roughly divided into three periods from occurrence to eventual regression: an advance period, a rest period, and a retreat period. Wherein, 1) a run period: new rash appears continuously, old rash expands continuously, scales are thick, inflammation is obvious, itching feeling is obvious, skin sensitivity is increased, and homomorphic reaction can occur; 2) and (3) a stationary period: no new rash and no regress of old rash; 3) a return period: inflammation subsides, scaling decreases, the rash shrinks and flattens, a pale halo appears around, and finally, temporary hypopigmentation or pigmentation remains.
Psoriasis is a chronic inflammatory skin disease, is easy to repeatedly attack and is difficult to radically cure, most patients have heavy winter and light summer, a few patients have heavy summer and light winter, the existing medicament for treating psoriasis has poor effect, the patients easily relapse and are difficult to radically cure, and the physical and mental health of the patients is seriously influenced.
Disclosure of Invention
Aiming at the problems in the prior art, the invention aims to provide the pharmaceutical composition for treating psoriasis and the preparation method thereof, the pharmaceutical composition has the advantages of cure rate of 95% for psoriasis patients, effective rate of 100% for treatment, high curative effect, no toxic or side effect, effective on the same day for mild patients and recovery in 10 days; the serious patient is effective on the same day, and can be cured in 25-28 days; and after treatment, the skin has no black spots outside the skin, no scars inside the skin and no relapse; the preparation method is simple and easy to operate and implement.
In order to achieve the purpose, the invention is realized by adopting the following technical scheme.
The pharmaceutical composition for treating psoriasis comprises the following raw materials: cortex Dictamni, cortex Picrasmae, radix Tripterygii Wilfordii, cortex Phellodendri, Oryza Glutinosa, herba Polygoni Hydropiperis, radix Rumicis, caulis et folium Caulophylli, caulis et folium Gaultheriae Yunnanensis, and water.
Preferably, the raw materials are used in the following amounts: 5-10 parts of cortex dictamni, 80-120 parts of bitter bark, 200 parts of tripterygium wilfordii 150-.
Further preferably, the raw materials are used in the following amounts: 7.5 parts of dittany bark, 105 parts of bitter bark, 175 parts of tripterygium wilfordii, 25 parts of phellodendron, 20 parts of glutinous rice ball, 80 parts of ludwigia prostrata, 45 parts of rumex madaio, 22.5 parts of Indigowoad root, 40 parts of radix seu folium Gaultheriae Yunnanensis and 2500 parts of water.
(II) a preparation method of a pharmaceutical composition for treating psoriasis, which comprises the following steps:
step 1, adding cortex dictamni, cortex picrasmae, tripterygium wilfordii, cortex phellodendri, glutinous rice balls, ludwigia prostrata, rheum officinale, Indigofera tinctoria and pangolin scales into water, and soaking to obtain a soaked substance;
and 2, decocting the soaked materials while adding water, and filtering to obtain the traditional Chinese medicine.
Preferably, in step 1, the soaking time is 25 to 35 minutes.
Preferably, in step 2, the decocting time is 3-6 hours, and the decocting temperature is 100 ℃.
Further preferably, in step 2, the decoction time is 4 hours.
Preferably, in the step 2, the water is added every 1-2 hours while decocting the medicine, and 0.5kg of water is added every time.
Preferably, in step 2, the filtration is performed by using a stainless steel net.
Compared with the prior art, the invention has the beneficial effects that:
the pharmaceutical composition for treating psoriasis is an external medicine, and has the main effects that: clearing heat, eliminating dampness, removing toxic substance, killing parasite, killing bacteria, relieving inflammation, softening crust, relieving itching, relieving pain, repairing necrotic cells, killing bacteria on superficial skin, and improving blood circulation. The main treatment is as follows: psoriasis, and can be used for treating dermatitis, eczema, tinea pedis, carbuncle, scabies, and scabies. Clinical tests prove that the mild patients are effective on the same day and are healed in 10 days; the serious patient is effective in the same day, and can be cured in 25-28 days. And no black spot on the skin, no scar in the skin and no recurrence after treatment. The test treatment is 530 cases totally, 503 cases are cured, 27 cases are effective, the cure rate is 95%, and the treatment effective rate is 100%. It has high curative effect and no toxic side effect.
Drawings
The invention is described in further detail below with reference to the figures and specific embodiments.
FIG. 1 is a graph showing the effects of case 1 patients of the present invention before and after the use of the pharmaceutical composition for treating psoriasis of the present application;
FIG. 2 is a graph showing the effects of the pharmaceutical composition for treating psoriasis of the present invention on patients of case 2 after 3 days and 10 days.
Detailed Description
Embodiments of the present invention will be described in detail below with reference to examples, but it will be understood by those skilled in the art that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention.
Example 1
Step 1, adding 7.5 g of cortex dictamni, 105 g of cortex picrasmae, 175 g of tripterygium wilfordii, 25 g of golden cypress, 20 g of glutinous rice balls, 80 g of ludwigia prostrata, 45 g of rheum officinale, 22.5 g of India cochinchinensis and 40 g of pangolin scales into 1.5kg of water, and soaking for 30 minutes to obtain a soaked substance;
and 2, decocting the soaked substances at 100 ℃ for 4 hours, adding 0.5kg of water every 2 hours in the decoction process, shearing, concentrating, and filtering by adopting a stainless steel net to obtain the Chinese medicinal composition.
Example 2
Step 1, adding 5g of cortex dictamni, 120 g of cortex picrasmae, 150 g of tripterygium wilfordii, 20 g of phellodendron amurense, 10 g of glutinous rice balls, 60 g of ludwigia prostrata, 50 g of rheum officinale, 30 g of Indigofera tinctoria and 50 g of pangolin scales into 2kg of water, and soaking for 30 minutes to obtain a soaked substance;
and 2, decocting the soaked substances at 100 ℃ for 5 hours, adding 0.5kg of water every 3 hours in the decoction process, shearing to concentrate, and filtering by adopting a stainless steel net to obtain the Chinese medicinal composition.
Example 3
Step 1, adding 10 g of cortex dictamni, 90 g of bitter tree bark, 200 g of tripterygium wilfordii, 25 g of phellodendron, 20 g of glutinous rice ball, 100 g of ludwigia prostrata, 60 g of rheum officinale, 15 g of India cochinchinensis and 50 g of pangolin scales into 1.5kg of water, and soaking for 30 minutes to obtain a soaked substance;
and 2, decocting the soaked substances at 100 ℃ for 4 hours, adding 0.5kg of water every 2 hours in the decoction process, shearing, concentrating, and filtering by adopting a stainless steel net to obtain the Chinese medicinal composition.
Example 4
Step 1, adding 8 g of cortex dictamni, 110 g of cortex picrasmae, 175 g of tripterygium wilfordii, 30 g of golden cypress, 30 g of glutinous rice balls, 80 g of ludwigia prostrata, 40 g of rheum officinale, 22 g of India cochinchinensis and 50 g of pangolin scales into 1.5kg of water, and soaking for 30 minutes to obtain a soaked substance;
and 2, decocting the soaked substances at 100 ℃ for 3 hours, adding 0.5kg of water every 1 hour in the decoction process, shearing, concentrating, and filtering by adopting a stainless steel net to obtain the Chinese medicinal composition.
Example 5
Step 1, adding 6 g of cortex dictamni, 90 g of bitter tree bark, 150 g of tripterygium wilfordii, 28 g of phellodendron, 10 g of glutinous rice ball, 70 g of ludwigia prostrata, 30 g of rheum officinale, 30 g of India cochinchinensis and 50 g of pangolin scales into 1.5g of water, and soaking for 30 minutes to obtain a soaked substance;
and 2, decocting the soaked substances at 100 ℃ for 6 hours, adding 0.5kg of water every 2 hours in the decoction process, shearing to concentrate, and filtering by adopting a stainless steel net to obtain the Chinese medicinal composition.
Example 6
Step 1, adding 7.5 g of cortex dictamni, 80 g of bitter tree bark, 180 g of tripterygium wilfordii, 22 g of golden cypress, 20 g of glutinous rice ball, 90 g of ludwigia prostrata, 37 g of rumex madaio, 40 g of India cayratia and 50 g of pangolin scales into 2.5kg of water, and soaking for 30 minutes to obtain a soaked substance;
and 2, decocting the soaked substances at 100 ℃ for 4 hours, adding 0.5kg of water every 2 hours in the decoction process, shearing, concentrating, and filtering by adopting a stainless steel net to obtain the Chinese medicinal composition.
In the above embodiment, the water is added every 1-2 hours in the decoction process, so that the liquid medicine is not stuck in a pot, various raw materials can be fully melted together, and the finally prepared pharmaceutical composition for treating psoriasis has better curative effect.
In the above implementation, the specific functions of the raw materials of the pharmaceutical composition for treating psoriasis are as follows: and (3) preparing cortex dictamni: clear heat and dry dampness, dispel wind and remove toxicity. Bitter bark: clear heat and dry dampness, remove toxicity and kill parasites. Thunder god vine: killing parasites, diminishing inflammation, detoxicating and relieving itching. Phellodendron bark: clear heat and dry dampness, purge fire and remove steam, remove toxicity and cure sore. Glutinous rice ball: to invigorate spleen, promote digestion, clear heat, remove dampness, detoxify and relieve swelling. Ludwigia prostrata: clearing away heat and toxic material, inducing diuresis for treating stranguria, removing blood stasis and stopping bleeding. Rhubarb root: clear heat and remove toxicity, cool blood and stop bleeding, resolve swelling and dissipate blood stasis. And (3) wood blue: clearing away heat and toxic material. Bone penetrating and dissipating: induce diuresis to treat stranguria, clear away heat and toxic material, dissipate blood stasis and relieve swelling.
The use method of the traditional Chinese medicine composition for treating psoriasis comprises the following steps: before use, the affected part needs to be soaked in hot water for 15-30 minutes to achieve the best curative effect, and after the skin is softened, the traditional Chinese medicine composition for treating psoriasis is applied to the affected part 3 times a day (respectively in the morning, the middle and the evening) and 2-5 times each time.
The traditional Chinese medicine composition for treating psoriasis is used for 530 clinical patients, wherein 503 and 27 patients are cured, the cure rate is 95 percent, the treatment effective rate is 100 percent, the curative effect is high, and no toxic or side effect exists. The curative effect is as follows: complete regression of the skin lesion or a regression of more than 95% is a complete cure. Clinical tests show that the patient with mild symptoms is effective on the same day, and the patient can be cured in 10 days; the serious patient is effective on the same day, and can be cured in 25-28 days; and no black spot outside the skin, no scar in the skin and no recurrence. The following are partial clinical trial results:
case 1
Schroeter, male, 53 years old, and patient has no obvious incentive for appearing reddish brown patch on the neck, clear boundary, inflammatory red halo around, obvious substrate infiltration, and multiple layers of dry silvery scales on the surface. The hospital diagnoses the psoriasis, and the psoriasis is treated by oral and external medicines, and the disease condition is repeated, and is mild and severe. After the traditional Chinese medicine composition for treating psoriasis, which is obtained in the embodiment 1 of the invention, is used for the 1 st time, the symptoms are obviously relieved, the disease condition is improved after 10 days, the scales are removed, the pruritus is eliminated, and only a small amount of skin damage is left (as shown in figure 1 specifically). After one year, no relapse is seen in follow-up visits.
Case 2
Zhangqi, male, age 52, with an initial inflammatory red papule on the radial side of the back of the hand, gradually enlarged to form a brownish red plaque, a dark red base, a small amount of white scale on the surface, and itching. When the local hospital diagnoses psoriasis, the disease condition is not improved by oral and external medicine treatment. By using the traditional Chinese medicine composition for treating psoriasis, which is obtained in the embodiment 1 of the invention, after 3 days, the skin lesions are resolved by 70%, the scales are resolved, and the pruritus disappears; after 10 days, all skin lesions disappeared and healed without any scar left (as shown in fig. 2). After one year, no relapse is seen in follow-up visits.
The clinical test effect of other examples is the same as that of example 1, and the formula dosage of each raw material in example 1 is verified to be the optimal raw material formula dosage through the clinical test.
Although the present invention has been described in detail in this specification with reference to specific embodiments and illustrative embodiments, it will be apparent to those skilled in the art that modifications and improvements can be made thereto based on the present invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.
Claims (8)
1. The pharmaceutical composition for treating psoriasis is characterized by comprising the following raw materials: cortex Dictamni, cortex Picrasmae, radix Tripterygii Wilfordii, cortex Phellodendri, Oryza Glutinosa, herba Polygoni Hydropiperis, radix Rumicis, caulis et folium Caulophylli, caulis et folium Gaultheriae Yunnanensis, and water.
2. The pharmaceutical composition for treating psoriasis according to claim 1, wherein the raw materials are used in amounts of: 5-10 parts of cortex dictamni, 80-120 parts of bitter bark, 200 parts of tripterygium wilfordii 150-.
3. The pharmaceutical composition for treating psoriasis according to claim 2, wherein the raw materials are used in amounts of: 7.5 parts of dittany bark, 105 parts of bitter bark, 175 parts of tripterygium wilfordii, 25 parts of phellodendron, 20 parts of glutinous rice ball, 80 parts of ludwigia prostrata, 45 parts of rumex madaio, 22.5 parts of Indigowoad root, 40 parts of radix seu folium Gaultheriae Yunnanensis and 2500 parts of water.
4. A method for preparing a pharmaceutical composition for treating psoriasis, comprising the steps of:
step 1, adding cortex dictamni, cortex picrasmae, tripterygium wilfordii, cortex phellodendri, glutinous rice balls, ludwigia prostrata, rheum officinale, Indigofera tinctoria and pangolin scales into water, and soaking to obtain a soaked substance;
and 2, decocting the soaked materials while adding water, and filtering to obtain the traditional Chinese medicine.
5. The method for preparing a pharmaceutical composition for treating psoriasis according to claim 4, wherein the soaking time in step 1 is 25 to 35 minutes.
6. The method for preparing a pharmaceutical composition for treating psoriasis as claimed in claim 4, wherein the decoction time is 3-6 hours and the decoction temperature is 100 ℃ in step 2.
7. The method for preparing a pharmaceutical composition for treating psoriasis as claimed in claim 6, wherein the decoction time in step 2 is 4 hours.
8. The method for preparing a pharmaceutical composition for treating psoriasis according to claim 4, wherein in the step 2, the water is added every 1-2 hours while decocting, and each time, the water is added by 0.5 kg.
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| CN103520483A (en) * | 2013-10-15 | 2014-01-22 | 陈友望 | Chinese medicinal vinegar bath formula |
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