CN115252743B - Traditional Chinese medicine composition and traditional Chinese medicine preparation for treating or preventing arthralgia - Google Patents
Traditional Chinese medicine composition and traditional Chinese medicine preparation for treating or preventing arthralgia Download PDFInfo
- Publication number
- CN115252743B CN115252743B CN202210994843.2A CN202210994843A CN115252743B CN 115252743 B CN115252743 B CN 115252743B CN 202210994843 A CN202210994843 A CN 202210994843A CN 115252743 B CN115252743 B CN 115252743B
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- traditional chinese
- radix
- treating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 53
- 239000000203 mixture Substances 0.000 title claims abstract description 50
- 208000006820 Arthralgia Diseases 0.000 title claims abstract description 39
- 238000002360 preparation method Methods 0.000 title claims abstract description 30
- 244000223760 Cinnamomum zeylanicum Species 0.000 claims abstract description 20
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 20
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 20
- 235000017803 cinnamon Nutrition 0.000 claims abstract description 20
- 240000004980 Rheum officinale Species 0.000 claims abstract description 19
- 235000008081 Rheum officinale Nutrition 0.000 claims abstract description 19
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 19
- 235000011477 liquorice Nutrition 0.000 claims abstract description 19
- 244000150195 Cyperus longus Species 0.000 claims abstract description 17
- 241000972672 Phellodendron Species 0.000 claims abstract description 17
- 244000111489 Gardenia augusta Species 0.000 claims abstract 5
- 240000004534 Scutellaria baicalensis Species 0.000 claims description 5
- 235000017089 Scutellaria baicalensis Nutrition 0.000 claims description 5
- 239000011505 plaster Substances 0.000 claims description 3
- 229940040145 liniment Drugs 0.000 claims description 2
- 239000000865 liniment Substances 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 239000002131 composite material Substances 0.000 claims 3
- 230000000694 effects Effects 0.000 abstract description 27
- 235000018109 Cyperus longus Nutrition 0.000 abstract 1
- 244000075634 Cyperus rotundus Species 0.000 abstract 1
- 235000005010 Scirpus paludosus Nutrition 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 26
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 19
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 16
- 229940116269 uric acid Drugs 0.000 description 16
- 241000157835 Gardenia Species 0.000 description 14
- 229940079593 drug Drugs 0.000 description 12
- 208000002193 Pain Diseases 0.000 description 11
- 230000036407 pain Effects 0.000 description 10
- 201000005569 Gout Diseases 0.000 description 8
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 230000003993 interaction Effects 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 6
- 241000218691 Cupressaceae Species 0.000 description 5
- 239000002671 adjuvant Substances 0.000 description 5
- 230000017531 blood circulation Effects 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 241000721047 Danaus plexippus Species 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 238000002791 soaking Methods 0.000 description 4
- 230000004087 circulation Effects 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
- 241000112528 Ligusticum striatum Species 0.000 description 2
- 241000219061 Rheum Species 0.000 description 2
- 235000009411 Rheum rhabarbarum Nutrition 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- NAFSTSRULRIERK-UHFFFAOYSA-M monosodium urate Chemical class [Na+].N1C([O-])=NC(=O)C2=C1NC(=O)N2 NAFSTSRULRIERK-UHFFFAOYSA-M 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 241001260012 Bursa Species 0.000 description 1
- 241000037740 Coptis chinensis Species 0.000 description 1
- 244000164480 Curcuma aromatica Species 0.000 description 1
- 235000003398 Curcuma aromatica Nutrition 0.000 description 1
- 241000099774 Cuscuta salina Species 0.000 description 1
- 235000017443 Hedysarum boreale Nutrition 0.000 description 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 description 1
- 201000001431 Hyperuricemia Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000972673 Phellodendron amurense Species 0.000 description 1
- 244000234609 Portulaca oleracea Species 0.000 description 1
- 235000001855 Portulaca oleracea Nutrition 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 241000207929 Scutellaria Species 0.000 description 1
- 241001369613 Stephania tetrandra Species 0.000 description 1
- 208000026816 acute arthritis Diseases 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 239000000571 coke Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 201000006334 interstitial nephritis Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 210000001258 synovial membrane Anatomy 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/237—Notopterygium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
- A61K36/8905—Cyperus (flatsedge)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine composition and a traditional Chinese medicine preparation for treating or preventing joint pain, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 15-30 parts of phellodendron, 10-25 parts of rheum officinale, 10-25 parts of radix scutellariae, 10-25 parts of gardenia, 4-10 parts of radix saposhnikoviae, 4-10 parts of notopterygium root, 4-10 parts of cinnamon, 10-25 parts of nutgrass galingale rhizome, 4-10 parts of radix curcumae and 4-10 parts of liquorice. The composition can effectively relieve joint pain and other problems caused by damp-heat blockage, and effectively solves the problems of numerous formula components and poor treatment effect of the existing composition.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition and a traditional Chinese medicine preparation for treating or preventing joint pain.
Background
Gout is a recurrent inflammatory disease caused by increased purine biosynthesis and metabolism, excessive uric acid production or elevated uric acid in blood due to poor uric acid excretion, and deposition of urate crystals in joint synovium, bursa, cartilage and other tissues. It is a group of heterologous diseases caused by the precipitation of monosodium urate crystals (MSU) or uric acid in the extracellular fluid in a supersaturated state, causing the crystals to deposit in tissues. The disease is characterized in that single-water sodium urate crystals with double refraction can be found in joint fluid and tophus. The clinical characteristics are as follows: hyperuricemia, characteristic acute arthritis, tophus and interstitial nephritis caused by urate crystallization and deposition, joint deformity and dysfunction are serious, and uric acid urinary tract calculus is often accompanied.
Gout belongs to the category of traditional Chinese medicine heat arthralgia, and heat arthralgia with local red swelling and heat pain as main symptoms is the common medicine components for treating rheumatic heat arthralgia on the market at present, and the medicine components mainly have the effects of diminishing inflammation and easing pain, so that the medicine has an unsatisfactory treatment effect on gout.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides a traditional Chinese medicine composition and a traditional Chinese medicine preparation for treating or preventing joint pain, which can effectively relieve the problems of joint pain and the like caused by damp-heat blockage and effectively solve the problems of numerous formula components and poor treatment effect of the traditional composition.
In order to achieve the above purpose, the technical scheme adopted by the invention for solving the technical problems is as follows:
A traditional Chinese medicine composition for treating or preventing joint pain comprises the following components in parts by weight: 15-30 parts of phellodendron, 10-25 parts of rheum officinale, 10-25 parts of radix scutellariae, 10-25 parts of gardenia, 4-10 parts of radix saposhnikoviae, 4-10 parts of notopterygium root, 4-10 parts of cinnamon, 10-25 parts of nutgrass galingale rhizome, 4-10 parts of radix curcumae and 4-10 parts of liquorice.
Further, the composition comprises the following components in parts by weight: 20-25 parts of phellodendron, 14-18 parts of rheum officinale, 14-18 parts of radix scutellariae, 14-18 parts of gardenia, 7-9 parts of radix sileris, 7-9 parts of notopterygium root, 7-9 parts of cinnamon, 14-18 parts of nutgrass galingale rhizome, 7-9 parts of radix curcumae and 7-9 parts of liquorice.
Further, the composition comprises the following components in parts by weight: 24 parts of phellodendron, 16 parts of rheum officinale, 16 parts of radix scutellariae, 16 parts of gardenia, 8 parts of radix sileris, 8 parts of notopterygium root, 8 parts of cinnamon, 16 parts of nutgrass galingale rhizome, 8 parts of radix curcumae and 8 parts of liquorice.
A Chinese medicinal preparation for treating or preventing arthralgia is prepared from the above Chinese medicinal composition.
Further, the Chinese medicinal preparation is an external preparation.
Further, the external preparation is a plaster, a liniment or a spray.
Further, the preparation method of the external preparation comprises the following steps: soaking the above Chinese medicinal materials in cold water in a marmite, preferably soaking the decoction pieces for about 2cm, boiling with strong fire for 30min, maintaining with slow fire for 15-20 min, filtering to obtain decoction, decocting with water for 2 times again, mixing the decoctions, and mixing with adjuvants to obtain topical preparation.
The beneficial effects of the invention are as follows:
the cortex phellodendri is reused as a monarch drug in the composition, and the composition has the effects of clearing heat, drying dampness, purging fire, removing toxin and treating sore and has the characteristic of walking down the coke; the rhubarb and the baical skullcap root are compatible as ministerial drugs, and the two drugs are used for clearing heat, drying dampness and detoxifying to assist the monarch drug amur corktree bark in dispelling pathogenic factors of damp-heat limb arthralgia; but also can promote blood circulation and remove blood stasis by using rhubarb to promote blood circulation and quickly improve pain symptoms. The gardenia, the radix sileris, the notopterygium root, the cinnamon, the nutgrass galingale rhizome, the radix curcumae and other medicines are added, wherein the gardenia is good at removing triple energizer, and the effects of clearing heat and purging fire, cooling blood and detoxifying remove damp-heat toxin accumulated in viscera and blood vessels are achieved, so that the monarch and ministerial medicine effect is comprehensively enhanced, and diseases caused by excessive pathogenic qi are prevented; wind-dispelling and dampness-removing effects of radix Saposhnikoviae and Notopterygii rhizoma can enhance arthralgia-relieving and pain-relieving effects; cinnamon is combined with rheum officinale and curcuma aromatica which activate blood to warm and dredge channels and collaterals to dredge the channels and relieve pain, and is combined with warm wind-proof, notopterygium root, nutgrass galingale rhizome and other medicines which are warm in nature, and auxiliary and ministerial medicines are adjunctively prepared to remove cold and stagnation and ice and stay evil, so that the Chinese medicine is prepared by dredging collaterals and removing arthralgia and relieving pain; the nutgrass galingale rhizome can promote qi circulation, not only can dissipate arthralgia and block qi stagnation, but also can promote qi circulation to promote blood circulation and remove arthralgia; radix Curcumae has effects of promoting blood circulation and relieving pain for blood heat stasis, cooling blood, dispelling blood stasis. The above 6 medicines or adjuvants or adjuvant systems are combined with each other as the adjuvant medicines in the prescription. The liquorice regulates all the medicines in the whole formula, so that cold and heat are suitable and the synergy is achieved; rou Gui, xiang Fu and Yu jin are all fragrant, so they can promote transdermal effect when used for external treatment, and Licorice root can be used as the guiding drug in the recipe. The whole formula is compatible, has the main effects of clearing heat, drying dampness, removing toxicity, promoting blood circulation, promoting qi circulation and dredging channels, and has the effects of relieving and promoting health and rehabilitation for inadaptation such as pain, swelling, joint movement limitation and the like caused by damp-heat blockage of joints.
Detailed Description
Example 1
A traditional Chinese medicine composition for treating or preventing joint pain comprises the following components in parts by weight: 17 parts of phellodendron, 13 parts of rheum officinale, 13 parts of radix scutellariae, 13 parts of gardenia, 6 parts of radix sileris, 6 parts of notopterygium root, 4 parts of cinnamon, 8 parts of nutgrass galingale rhizome, 6 parts of radix curcumae and 7 parts of liquorice.
The preparation method of the external preparation prepared from the composition comprises the following steps: soaking the above Chinese medicinal materials in cold water in a marmite, preferably soaking the decoction pieces for about 2cm, boiling with strong fire for 30min, maintaining with slow fire for 15-20 min, filtering to obtain decoction, decocting with water for 2 times again, mixing the decoctions, and mixing with adjuvants to obtain topical plaster.
Example 2
A traditional Chinese medicine composition for treating or preventing joint pain comprises the following components in parts by weight: 27 parts of phellodendron, 20 parts of rheum officinale, 14 parts of radix scutellariae, 20 parts of gardenia, 6 parts of radix saposhnikoviae, 6 parts of notopterygium root, 9 parts of cinnamon, 20 parts of nutgrass galingale rhizome, 9 parts of radix curcumae and 8 parts of liquorice.
The preparation method is the same as in example 1.
Example 3
A traditional Chinese medicine composition for treating or preventing joint pain comprises the following components in parts by weight: 22 parts of phellodendron, 18 parts of rheum officinale, 18 parts of scutellaria baicalensis, 12 parts of gardenia, 8 parts of radix sileris, 9 parts of notopterygium root, 10 parts of cinnamon, 22 parts of nutgrass galingale rhizome, 10 parts of radix curcumae and 7 parts of liquorice.
The preparation method is the same as in example 1.
Example 4
A traditional Chinese medicine composition for treating or preventing joint pain comprises the following components in parts by weight: 24 parts of phellodendron, 16 parts of rheum officinale, 16 parts of radix scutellariae, 16 parts of gardenia, 8 parts of radix sileris, 8 parts of notopterygium root, 8 parts of cinnamon, 16 parts of nutgrass galingale rhizome, 8 parts of radix curcumae and 8 parts of liquorice.
The preparation method is the same as in example 1.
Comparative example 1
A traditional Chinese medicine composition for treating or preventing joint pain comprises the following components in parts by weight: 24 parts of coptis chinensis, 16 parts of rheum officinale, 16 parts of scutellaria baicalensis, 16 parts of gardenia, 8 parts of radix saposhnikoviae, 8 parts of notopterygium root, 8 parts of cinnamon, 16 parts of rhizoma cyperi, 8 parts of radix curcumae and 8 parts of liquorice.
The preparation method is the same as in example 1.
Comparative example 2
A traditional Chinese medicine composition for treating or preventing joint pain comprises the following components in parts by weight: 24 parts of phellodendron, 16 parts of ligusticum wallichii, 16 parts of radix scutellariae, 16 parts of gardenia, 8 parts of radix sileris, 8 parts of notopterygium root, 8 parts of cinnamon, 16 parts of rhizoma cyperi, 8 parts of radix curcumae and 8 parts of liquorice.
The preparation method is the same as in example 1.
Comparative example 3
A traditional Chinese medicine composition for treating or preventing joint pain comprises the following components in parts by weight: 24 parts of phellodendron, 16 parts of rheum officinale, 16 parts of scutellaria baicalensis, 16 parts of purslane, 8 parts of radix sileris, 8 parts of notopterygium root, 8 parts of cinnamon, 16 parts of rhizoma cyperi, 8 parts of radix curcumae and 8 parts of liquorice.
The preparation method is the same as in example 1.
Comparative example 4
A traditional Chinese medicine composition for treating or preventing joint pain comprises the following components in parts by weight: 24 parts of phellodendron, 16 parts of rheum officinale, 16 parts of radix scutellariae, 16 parts of gardenia, 8 parts of radix saposhnikoviae, 8 parts of radix angelicae pubescentis, 8 parts of cinnamon, 16 parts of rhizoma cyperi, 8 parts of radix curcumae and 8 parts of liquorice.
The preparation method is the same as in example 1.
Comparative example 5
A traditional Chinese medicine composition for treating or preventing joint pain comprises the following components in parts by weight: 24 parts of phellodendron, 16 parts of rheum officinale, 16 parts of radix scutellariae, 16 parts of gardenia, 8 parts of stephania tetrandra, 8 parts of notopterygium root, 8 parts of cinnamon, 16 parts of nutgrass galingale rhizome, 8 parts of radix curcumae and 8 parts of liquorice.
The preparation method is the same as in example 1.
Comparative example 6
A traditional Chinese medicine composition for treating or preventing joint pain comprises the following components in parts by weight: 10 parts of phellodendron, 25 parts of rheum officinale, 25 parts of scutellaria baicalensis, 10 parts of gardenia, 8 parts of radix sileris, 8 parts of notopterygium root, 5 parts of cinnamon, 16 parts of nutgrass galingale rhizome, 12 parts of radix curcumae and 8 parts of liquorice.
The preparation method is the same as in example 1.
Test examples
1. Treatment of gout
1. Clinical data
1.1 Patients 200 persons in the period of onset of gout, with the age between 35 and 66 years, with the average age of 46.3 years, were collected for clinical diagnosis in the period of time 2020-2022, were randomized into 10 groups of 20 persons each, were comparable between each group of patients, uric acid levels of each group of patients were measured and uric acid averages of the group of patients were calculated, uric acid averages of each group of patients were used as uric acid data of the group of patients, and then the patches of examples 1-4 and comparative examples 1-6 were used for each group of patients, respectively, one patch per day for 3 consecutive days, and uric acid levels of each group of patients were continuously measured and uric acid averages of each group of patients were calculated, with specific results shown in table 1.
Table 1: uric acid content
| Uric acid content (umol/L) before use | Uric acid content after use (umol/L) | |
| Example 1 | 582.1 | 298.4 |
| Example 2 | 548.3 | 284.2 |
| Example 3 | 542.2 | 279.6 |
| Example 4 | 576.8 | 251.2 |
| Comparative example 1 | 539.8 | 487.2 |
| Comparative example 2 | 551.7 | 445.7 |
| Comparative example 3 | 566.3 | 444.1 |
| Comparative example 4 | 541.5 | 435.7 |
| Comparative example 5 | 568.6 | 429.2 |
| Comparative example 6 | 547.5 | 401.3 |
As can be seen from the data in the above table, the Chinese medicinal compositions in examples 1-4 can effectively reduce uric acid content in hematuria and relieve pain of patients; however, the effect of reducing uric acid content of patients is not as obvious as that of the composition in examples after the formulas of the traditional Chinese medicine compositions in comparative examples 1-6 are changed, namely, the traditional Chinese medicine composition claimed in the application has obvious effect of treating pains caused by gout.
2. Treatment of joint pain without explicit cause
200 Patients with joint pain, who had undergone hospital visit in the clinic between 2020 and 2022 years, were collected, the ages of the patients were between 30 and 66 years, all patients were excluded from the possibility of gout, the patients were randomly divided into 10 groups of 20 persons, the patches in examples 1 to 4 and comparative examples 1 to 6 were used for 10 groups of patients, respectively, 1 time a day for 3 days, and the conditions of the patients were observed and recorded, and the specific results are shown in table 2.
Diagnostic criteria:
the method is effective: the symptoms of joint pain of the patient are reduced;
Invalidation: the symptoms of the joint pain of the patient have no obvious change;
and (3) healing: the symptoms of the joint pain of the patient completely disappear;
effective rate = (effective number + healed number)/total number × 100%
Table 2: treatment of joint pain
| Headcount (person) | Effective number of people (people) | The number of people (people) healed | Invalid person number (person) | Cure rate (%) | |
| Example 1 | 20 | 10 | 10 | 0 | 100 |
| Example 2 | 20 | 8 | 12 | 0 | 100 |
| Example 3 | 20 | 7 | 13 | 0 | 100 |
| Example 4 | 20 | 5 | 15 | 0 | 100 |
| Comparative example 1 | 20 | 12 | 1 | 7 | 65 |
| Comparative example 2 | 20 | 14 | 2 | 4 | 80 |
| Comparative example 3 | 20 | 14 | 1 | 5 | 75 |
| Comparative example 4 | 20 | 15 | 2 | 3 | 85 |
| Comparative example 5 | 20 | 15 | 2 | 3 | 85 |
| Comparative example 6 | 20 | 14 | 1 | 5 | 75 |
From the results in the above tables, it is known that the Chinese medicinal compositions in examples 1 to 4 also have a better therapeutic effect on joint pain caused by non-gout, and the therapeutic effect is far higher than that of the Chinese medicinal compositions in comparative examples 1 to 6.
Clinical application shows that the external preparation of the traditional Chinese medicine composition has a good treatment effect on the arthralgia in the attack stage, and can effectively relieve the pain symptoms of patients.
Comparing the traditional Chinese medicine composition in comparative example 1 with the traditional Chinese medicine composition in example 4, the golden cypress is replaced by the golden thread with similar action, and the treatment effect of the replaced golden cypress is obviously deteriorated although the action of the golden cypress is similar, and the fact that the golden cypress used in the application has interaction with other medicines proves that the whole treatment effect of the prescription can be improved, and the interaction between the prescriptions disappears after the golden cypress is replaced, so that the treatment effect is poor.
Comparing the traditional Chinese medicine composition in comparative example 2 with the traditional Chinese medicine composition in example 4, the rheum officinale is replaced by ligusticum wallichii with similar effect, but the result shows that the treatment effect of the replaced formula is poor, and the traditional Chinese medicine composition has interaction relationship with other components, so that the interaction relationship in the replaced formula disappears to cause the poor treatment effect.
The traditional Chinese medicine compositions in comparative examples 3-5 also respectively replace components in the compositions, and the results show that the treatment effect of the replaced compositions is poor, and the results prove that the interaction relationship between the replaced compositions is changed, so that the treatment effect is poor, and further prove that the compositions have interaction synergistic effect and have better treatment effect when being matched.
Comparing the traditional Chinese medicine composition of comparative example 6 with example 4, the composition has unchanged components, but the dosage of the components changes, and the result shows that the treatment effect of the changed composition also becomes poor, which proves that the monarch, minister, assistant and guide relationship in the composition with changed dosage changes correspondingly, so that the treatment effect of the composition changes.
Claims (4)
1. The traditional Chinese medicine composition for treating or preventing joint pain is characterized by comprising the following components in parts by weight: 17 parts of phellodendron, 13 parts of rheum officinale, 13 parts of radix scutellariae, 13 parts of gardenia, 6 parts of radix sileris, 6 parts of notopterygium root, 4 parts of cinnamon, 8 parts of nutgrass galingale rhizome, 6 parts of radix curcumae and 7 parts of liquorice; or (b)
The composite material consists of the following components in parts by weight: 27 parts of phellodendron, 20 parts of rheum officinale, 14 parts of radix scutellariae, 20 parts of gardenia, 6 parts of radix saposhnikoviae, 6 parts of notopterygium root, 9 parts of cinnamon, 20 parts of nutgrass galingale rhizome, 9 parts of radix curcumae and 8 parts of liquorice; or (b)
The composite material consists of the following components in parts by weight: 22 parts of phellodendron, 18 parts of rheum officinale, 18 parts of scutellaria baicalensis, 12 parts of gardenia, 8 parts of radix sileris, 9 parts of notopterygium root, 10 parts of cinnamon, 22 parts of nutgrass galingale rhizome, 10 parts of radix curcumae and 7 parts of liquorice; or (b)
The composite material consists of the following components in parts by weight: 24 parts of phellodendron, 16 parts of rheum officinale, 16 parts of radix scutellariae, 16 parts of gardenia, 8 parts of radix sileris, 8 parts of notopterygium root, 8 parts of cinnamon, 16 parts of nutgrass galingale rhizome, 8 parts of radix curcumae and 8 parts of liquorice.
2. A traditional Chinese medicine preparation for treating or preventing joint pain, which is characterized by being prepared from the traditional Chinese medicine composition of claim 1.
3. The Chinese medicinal preparation for treating or preventing joint pain according to claim 2, wherein the preparation is an external preparation.
4. The Chinese medicinal preparation for treating or preventing joint pain according to claim 3, wherein the external preparation is a plaster, a liniment or a spray.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210994843.2A CN115252743B (en) | 2022-08-18 | 2022-08-18 | Traditional Chinese medicine composition and traditional Chinese medicine preparation for treating or preventing arthralgia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210994843.2A CN115252743B (en) | 2022-08-18 | 2022-08-18 | Traditional Chinese medicine composition and traditional Chinese medicine preparation for treating or preventing arthralgia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115252743A CN115252743A (en) | 2022-11-01 |
| CN115252743B true CN115252743B (en) | 2024-04-19 |
Family
ID=83753490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210994843.2A Active CN115252743B (en) | 2022-08-18 | 2022-08-18 | Traditional Chinese medicine composition and traditional Chinese medicine preparation for treating or preventing arthralgia |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115252743B (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988558A (en) * | 2012-11-29 | 2013-03-27 | 王萍 | Healthful traditional Chinese medicine composition for gouty arthritis |
| CN105664056A (en) * | 2016-03-17 | 2016-06-15 | 孙绍裘 | Traditional Chinese medicine composition for treating orthopedic diseases, preparing method of traditional Chinese medicine composition and preparation |
-
2022
- 2022-08-18 CN CN202210994843.2A patent/CN115252743B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988558A (en) * | 2012-11-29 | 2013-03-27 | 王萍 | Healthful traditional Chinese medicine composition for gouty arthritis |
| CN105664056A (en) * | 2016-03-17 | 2016-06-15 | 孙绍裘 | Traditional Chinese medicine composition for treating orthopedic diseases, preparing method of traditional Chinese medicine composition and preparation |
Non-Patent Citations (2)
| Title |
|---|
| 三黄散内服外敷治疗急性痛风性关节炎;彭育新;《中国中医急症》;第21卷(第7期);1156 * |
| 金黄栀子散外敷治疗急性扭挫伤86例;王运太 等;《中医外治杂志》(第2期);47 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN115252743A (en) | 2022-11-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110721219A (en) | Traditional Chinese medicine for treating allergic rhinitis | |
| CN103735927B (en) | A kind of Chinese medicine composition for the treatment of acute stage of gout and preparation method thereof | |
| CN107854683A (en) | A kind of plaster for treating damp and hot numbness type knee osteoarthritis | |
| CN115252743B (en) | Traditional Chinese medicine composition and traditional Chinese medicine preparation for treating or preventing arthralgia | |
| CN104689132A (en) | Traditional Chinese medicine composition for treating psoriasis | |
| CN102784343B (en) | External use traditional Chinese medicine preparation for treating psoriasis | |
| CN102357215B (en) | Ointment for treating right hypochondriac distention and pain caused by acute and chronic cholecystitis | |
| CN103877462A (en) | External liniment for treating psoriasis and preparation method thereof | |
| CN114028511A (en) | Traditional Chinese medicine composition for treating intractable gout and application thereof | |
| CN108619427B (en) | Pain-relieving and acid-reducing herb tea for preventing and treating gouty arthritis | |
| CN105031596A (en) | Ointment for treating nummular eczema and preparing method thereof | |
| CN110893206B (en) | Externally applied medicine for treating rheumatic arthritis and preparation method thereof | |
| CN104398910B (en) | A kind of Chinese medicine preparation for being used to treat synovitis | |
| CN115054644B (en) | Traditional Chinese medicine composition for treating diabetic foot and preparation method thereof | |
| CN101983681A (en) | Medicament for treating abnormal leucorrhea | |
| CN114886959B (en) | Pharmaceutical composition, preparation and application thereof | |
| CN108578549B (en) | Medicine for treating acne and application thereof | |
| CN110448601B (en) | Traditional Chinese medicine composition for treating migraine | |
| CN103479822B (en) | Traditional Chinese unguent capable of preventing and treating wound infection and preparation method of traditional Chinese unguent | |
| CN110496199B (en) | Medicine for treating psoriasis and preparation method thereof | |
| CN117045745A (en) | Traditional Chinese medicine composition for treating anal fissure | |
| CN118078896A (en) | Traditional Chinese medicine fumigation lotion for auxiliary treatment of internal hemorrhoids | |
| CN116726107A (en) | Externally applied traditional Chinese medicine for treating acute gouty arthritis and preparation method thereof | |
| CN104306734A (en) | Plaster preparation for external use for treating diabetic gangrene and preparation method thereof | |
| CN104257967A (en) | Traditional Chinese medicine for treating sports injury |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |