CN102357215B - Ointment for treating right hypochondriac distention and pain caused by acute and chronic cholecystitis - Google Patents
Ointment for treating right hypochondriac distention and pain caused by acute and chronic cholecystitis Download PDFInfo
- Publication number
- CN102357215B CN102357215B CN 201110362407 CN201110362407A CN102357215B CN 102357215 B CN102357215 B CN 102357215B CN 201110362407 CN201110362407 CN 201110362407 CN 201110362407 A CN201110362407 A CN 201110362407A CN 102357215 B CN102357215 B CN 102357215B
- Authority
- CN
- China
- Prior art keywords
- bletillae
- pseudobulbus
- rhizoma
- add
- myrrha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to an ointment for treating right hypochondriac distention and pain caused by acute and chronic cholecystitis, which effectively solves the treatment problems of right hypochondriac distention and pain caused by acute and chronic cholecystitis; the technical scheme solved by the invention is that the ointment is prepared by the following raw materials: 5-15 g of bletilla striata, 5-15 g of rhizoma corydalis, 3-7 g of borneol, 5-15 g of desmodium, 5-15 g of frankincense, 5-15 g of myrrh, 3-7 g of rhizoma pleionis, 5-15 g of spina gleditsiae, 5-15 g of coix seeds, 3-5 g ofhydrogel matrix, 0.5-1 ml of glycerol, and 1-1.5 g of polyethylene glycol 400; the invention has the efficacy of clearing heat, activating blood, rectifying qi and relieving pain, and is mainly used to treat symptoms of right hypochondriac distention and pain caused by cholecystitis and cholelithiasis; the invention has good curative effect, low cost, is easy to produce, is convenient for carrying, is easy to use, can relieve pain rapidly, and mitigate pain of patients.
Description
Technical field
The present invention relates to field of medicaments, particularly a kind of right flank distension that acute and chronic cholecystitis causes, ointment of pain for the treatment of.
Background technology
Cholecystitis is the gallbladder inflammatory lesion that bacterial infection or chemical irritation (bile component change) cause, cardinal symptom is that upper right abdomen aches, feels sick, vomits and heating.Cholecystitis has acute and chronic dividing.Acute cholecystitis refer to by antibacterial infect, highly concentrated bile or the anti-caused acute cholecystitis disease of chemical stimulation that flows into the pancreatic juice of gallbladder.Clinical symptoms is heating, right hypochondrial region and tenderness, vomiting, leucocytosis etc.Chronic cholecystitis is gallbladder chronic inflammation pathological changes, and many and cholelithiasis exists simultaneously, and minority is non-calcareous cholecystitis, sometimes can be the rear something lost disease of acute cholecystitis.Primary disease belongs to the category of the traditional Chinese medical science " hypochondriac pain " and " gallbladder-distention ", and sickness rate is high among the crowd, easily repeatedly outbreak, and obstinate has a strong impact on Quality of Life.Treatment cholecystitis Chinese medicine is more at present, comprises oral formulations, externally applied ointment etc.Prepared slices of Chinese crude drugs treatments mainly with the differentiation of symptoms and signs for classification of syndrome opinion control, the treatment of classical prescription plus-minus, certainly plans side treatment plus-minus treatment, but clinical efficacy differs greatly, and inconvenient timely the treatment; The Chinese patent drugs for treatment kind is more, such as XIAOYAN LIDAN PIAN, DANNING PIAN, cholagogic tablet etc., the local points acupuncture of application and moxibustion treatment method is arranged also.But curative effect is all not too sure.The Drug therapy Different therapeutical effect is larger generally, and uses inconvenience, and many patients do not have good treatment means and aggravate disease when morbidity.
Summary of the invention
For above-mentioned situation, the present invention's purpose just provides a kind of right flank distension that acute and chronic cholecystitis causes for the treatment of, and the ointment of pain can effectively solve the right flank distension that acute and chronic cholecystitis causes, the treatment problem of pain.
The technical scheme that the present invention solves is: this ointment be by: Pseudobulbus Bletillae (Rhizoma Bletillae) 5-15g, Rhizoma Corydalis 5-15g, Borneolum Syntheticum 3-7g, Herba Lysimachiae 5-15g, Olibanum 5-15g, Myrrha 5-15g, Pseudobulbus cremastrae seu pleiones 3-7g, Spina Gleditsiae 5-15g, Semen Coicis 5-15g, hydrogel matrix 3-5g, glycerol 0.5-1ml and PEG400 1-1.5g make as raw material, wherein: the 1) preparation of hydrogel matrix: carbopol 940 3g are added in the 30ml distilled water, swelling, add again ethyl hydroxybenzoate 0.05g and azone 3.6ml, stir and get final product; 2) Pseudobulbus Bletillae (Rhizoma Bletillae) powder is broken into fine powder, crosses 200 mesh sieves, get Pseudobulbus Bletillae (Rhizoma Bletillae) powder; Olibanum and Myrrha mix, be ground into granule, add Olibanum and Myrrha weight and 8 times of water gagings, distilled 6 hours, collect volatile oil, medical filtration gets filtering solution, and is for subsequent use, medicinal residues and Rhizoma Corydalis and Semen Coicis merge, get hybrid medicine, hybrid medicine adds Olibanum at every turn, Myrrha, the mass concentration of Rhizoma Corydalis and Semen Coicis weight and 6 times of amounts is 85% ethanol, reflux, extract, 2 times, each 1.5 hours, filter merging filtrate, decompression recycling ethanol, get mixed liquor, Pseudobulbus cremastrae seu pleiones, Spina Gleditsiae and Herba Lysimachiae add Pseudobulbus cremastrae seu pleiones at every turn, Spina Gleditsiae and Herba Lysimachiae weight and 8 times of water gagings, decoct each 1.5 hours 2 times, filter, merging filtrate, and merge with filtering solution and mixed liquor behind the above-mentioned collection volatile oil, be evaporated to 60 ℃ of thick extractum of measuring relative density 1.2-1.3; 3) get Pseudobulbus Bletillae (Rhizoma Bletillae) powder, add glycerol, ground 8-10 minute, Pseudobulbus Bletillae (Rhizoma Bletillae) cream, it is 95% dissolve with ethanol that Borneolum Syntheticum adds mass concentration, gets lysate, volatile oil adds polyoxyethylene sorbitan monoleate 0.2g and grinds well, Pseudobulbus Bletillae (Rhizoma Bletillae) cream, lysate and add volatile oil that polyoxyethylene sorbitan monoleate 0.2g grinds well and thick extractum and hydrogel matrix mix grind well, and get compound; Then with PEG400, oil bath is heated to 90-100 ℃ of melting, add in the compound, and mixing, and get final product.
The present invention has the effect of heat clearing and blood circulation promoting, regulating QI to relieve pain, cures mainly the right flank distension that cholecystitis and cholelithiasis cause, the symptoms such as pain, and good effect of the present invention, cost is low, is easy to produce, and is easy to carry, is easy to use, and rapidly pain relieving alleviates the patient suffering.
The specific embodiment
Below in conjunction with embodiment the specific embodiment of the present invention is elaborated.
Embodiment 1:
The present invention is made as raw material by Pseudobulbus Bletillae (Rhizoma Bletillae) 10g, Rhizoma Corydalis 10g, Borneolum Syntheticum 5g, Herba Lysimachiae 10g, Olibanum 5g, Myrrha 5g, Pseudobulbus cremastrae seu pleiones 5g, Spina Gleditsiae 10g, Semen Coicis 5g, hydrogel matrix 5g, glycerol 1ml and PEG400 1.5g, wherein: the 1) preparation of hydrogel matrix: carbopol 940 3g are added in the 30ml distilled water, swelling, add again ethyl hydroxybenzoate 0.05g and azone 3.6ml, stir and get final product; 2) Pseudobulbus Bletillae (Rhizoma Bletillae) powder is broken into fine powder, crosses 200 mesh sieves, get Pseudobulbus Bletillae (Rhizoma Bletillae) powder; Olibanum and Myrrha mix, be ground into granule, add Olibanum and Myrrha weight and 8 times of water gagings, distilled 6 hours, collect volatile oil, medical filtration gets filtering solution, and is for subsequent use, medicinal residues and Rhizoma Corydalis and Semen Coicis merge, get hybrid medicine, hybrid medicine adds Olibanum at every turn, Myrrha, the mass concentration of Rhizoma Corydalis and Semen Coicis weight and 6 times of amounts is 85% ethanol, reflux, extract, 2 times, each 1.5 hours, filter merging filtrate, decompression recycling ethanol, get mixed liquor, Pseudobulbus cremastrae seu pleiones, Spina Gleditsiae and Herba Lysimachiae add Pseudobulbus cremastrae seu pleiones at every turn, Spina Gleditsiae and Herba Lysimachiae weight and 8 times of water gagings, decoct each 1.5 hours 2 times, filter, merging filtrate, and merge with filtering solution and mixed liquor behind the above-mentioned collection volatile oil, be evaporated to 60 ℃ of thick extractum of measuring relative densities 1.2; 3) get Pseudobulbus Bletillae (Rhizoma Bletillae) powder, add glycerol, ground 9 minutes, Pseudobulbus Bletillae (Rhizoma Bletillae) cream, it is 95% dissolve with ethanol that Borneolum Syntheticum adds mass concentration, gets lysate, volatile oil adds polyoxyethylene sorbitan monoleate 0.2g and grinds well, Pseudobulbus Bletillae (Rhizoma Bletillae) cream, lysate and add volatile oil that polyoxyethylene sorbitan monoleate 0.2g grinds well and thick extractum and hydrogel matrix mix grind well, and get compound; Then with PEG400, oil bath is heated to 95 ℃ of meltings, add in the compound, and mixing, and get final product.
Embodiment 2:
The present invention be by: Pseudobulbus Bletillae (Rhizoma Bletillae) 5g, Rhizoma Corydalis 5g, Borneolum Syntheticum 3g, Herba Lysimachiae 5g, Olibanum 5g, Myrrha 5g, Pseudobulbus cremastrae seu pleiones 3g, Spina Gleditsiae 5g, Semen Coicis 5g, hydrogel matrix 3g, glycerol 0.5ml and PEG400 1g make as raw material, wherein: the 1) preparation of hydrogel matrix: carbopol 940 3g are added in the 30ml distilled water, swelling, add again ethyl hydroxybenzoate 0.05g and azone 3.6ml, stir and get final product; 2) Pseudobulbus Bletillae (Rhizoma Bletillae) powder is broken into fine powder, crosses 200 mesh sieves, get Pseudobulbus Bletillae (Rhizoma Bletillae) powder; Olibanum and Myrrha mix, be ground into granule, add Olibanum and Myrrha weight and 8 times of water gagings, distilled 6 hours, collect volatile oil, medical filtration gets filtering solution, and is for subsequent use, medicinal residues and Rhizoma Corydalis and Semen Coicis merge, get hybrid medicine, hybrid medicine adds Olibanum at every turn, Myrrha, the mass concentration of Rhizoma Corydalis and Semen Coicis weight and 6 times of amounts is 85% ethanol, reflux, extract, 2 times, each 1.5 hours, filter merging filtrate, decompression recycling ethanol, get mixed liquor, Pseudobulbus cremastrae seu pleiones, Spina Gleditsiae and Herba Lysimachiae add Pseudobulbus cremastrae seu pleiones at every turn, Spina Gleditsiae and Herba Lysimachiae weight and 8 times of water gagings, decoct each 1.5 hours 2 times, filter, merging filtrate, and merge with filtering solution and mixed liquor behind the above-mentioned collection volatile oil, be evaporated to 60 ℃ of thick extractum of measuring relative densities 1.3; 3) get Pseudobulbus Bletillae (Rhizoma Bletillae) powder, add glycerol, ground 8 minutes, Pseudobulbus Bletillae (Rhizoma Bletillae) cream, it is 95% dissolve with ethanol that Borneolum Syntheticum adds mass concentration, gets lysate, volatile oil adds polyoxyethylene sorbitan monoleate 0.2g and grinds well, Pseudobulbus Bletillae (Rhizoma Bletillae) cream, lysate and add volatile oil that polyoxyethylene sorbitan monoleate 0.2g grinds well and thick extractum and hydrogel matrix mix grind well, and get compound; Then with PEG400, oil bath is heated to 90 ℃ of meltings, add in the compound, and mixing, and get final product.
Embodiment 3:
The present invention be by: Pseudobulbus Bletillae (Rhizoma Bletillae) 15g, Rhizoma Corydalis 15g, Borneolum Syntheticum 7g, Herba Lysimachiae 15g, Olibanum 15g, Myrrha 15g, Pseudobulbus cremastrae seu pleiones 7g, Spina Gleditsiae 15g, Semen Coicis 15g, hydrogel matrix 5g, glycerol 1ml and PEG400 1.5g make as raw material, wherein: the 1) preparation of hydrogel matrix: carbopol 940 3g are added in the 30ml distilled water, swelling, add again ethyl hydroxybenzoate 0.05g and azone 3.6ml, stir and get final product; 2) Pseudobulbus Bletillae (Rhizoma Bletillae) powder is broken into fine powder, crosses 200 mesh sieves, get Pseudobulbus Bletillae (Rhizoma Bletillae) powder; Olibanum and Myrrha mix, be ground into granule, add Olibanum and Myrrha weight and 8 times of water gagings, distilled 6 hours, collect volatile oil, medical filtration gets filtering solution, and is for subsequent use, medicinal residues and Rhizoma Corydalis and Semen Coicis merge, get hybrid medicine, hybrid medicine adds Olibanum at every turn, Myrrha, the mass concentration of Rhizoma Corydalis and Semen Coicis weight and 6 times of amounts is 85% ethanol, reflux, extract, 2 times, each 1.5 hours, filter merging filtrate, decompression recycling ethanol, get mixed liquor, Pseudobulbus cremastrae seu pleiones, Spina Gleditsiae and Herba Lysimachiae add Pseudobulbus cremastrae seu pleiones at every turn, Spina Gleditsiae and Herba Lysimachiae weight and 8 times of water gagings, decoct each 1.5 hours 2 times, filter, merging filtrate, and merge with filtering solution and mixed liquor behind the above-mentioned collection volatile oil, be evaporated to 60 ℃ of thick extractum of measuring relative densities 1.3; 3) get Pseudobulbus Bletillae (Rhizoma Bletillae) powder, add glycerol, ground 10 minutes, Pseudobulbus Bletillae (Rhizoma Bletillae) cream, it is 95% dissolve with ethanol that Borneolum Syntheticum adds mass concentration, gets lysate, volatile oil adds polyoxyethylene sorbitan monoleate 0.2g and grinds well, Pseudobulbus Bletillae (Rhizoma Bletillae) cream, lysate and add volatile oil that polyoxyethylene sorbitan monoleate 0.2g grinds well and thick extractum and hydrogel matrix mix grind well, and get compound; Then with PEG400, oil bath is heated to 100 ℃ of meltings, add in the compound, and mixing, and get final product.
Embodiment 4:
The present invention be by: Pseudobulbus Bletillae (Rhizoma Bletillae) 10g, Rhizoma Corydalis 10g, Borneolum Syntheticum 5g, Herba Lysimachiae 10g, Olibanum 10g, Myrrha 10g, Pseudobulbus cremastrae seu pleiones 5g, Spina Gleditsiae 10g, Semen Coicis 10g, hydrogel matrix 4g, glycerol 0.8ml and PEG400 1.3g make as raw material, wherein: the 1) preparation of hydrogel matrix: carbopol 940 3g are added in the 30ml distilled water, swelling, add again ethyl hydroxybenzoate 0.05g and azone 3.6ml, stir and get final product; 2) Pseudobulbus Bletillae (Rhizoma Bletillae) powder is broken into fine powder, crosses 200 mesh sieves, get Pseudobulbus Bletillae (Rhizoma Bletillae) powder; Olibanum and Myrrha mix, be ground into granule, add Olibanum and Myrrha weight and 8 times of water gagings, distilled 6 hours, collect volatile oil, medical filtration gets filtering solution, and is for subsequent use, medicinal residues and Rhizoma Corydalis and Semen Coicis merge, get hybrid medicine, hybrid medicine adds Olibanum at every turn, Myrrha, the mass concentration of Rhizoma Corydalis and Semen Coicis weight and 6 times of amounts is 85% ethanol, reflux, extract, 2 times, each 1.5 hours, filter merging filtrate, decompression recycling ethanol, get mixed liquor, Pseudobulbus cremastrae seu pleiones, Spina Gleditsiae and Herba Lysimachiae add Pseudobulbus cremastrae seu pleiones at every turn, Spina Gleditsiae and Herba Lysimachiae weight and 8 times of water gagings, decoct each 1.5 hours 2 times, filter, merging filtrate, and merge with filtering solution and mixed liquor behind the above-mentioned collection volatile oil, be evaporated to 60 ℃ of thick extractum of measuring relative densities 1.3; 3) get Pseudobulbus Bletillae (Rhizoma Bletillae) powder, add glycerol, ground 9 minutes, Pseudobulbus Bletillae (Rhizoma Bletillae) cream, it is 95% dissolve with ethanol that Borneolum Syntheticum adds mass concentration, gets lysate, volatile oil adds polyoxyethylene sorbitan monoleate 0.2g and grinds well, Pseudobulbus Bletillae (Rhizoma Bletillae) cream, lysate and add volatile oil that polyoxyethylene sorbitan monoleate 0.2g grinds well and thick extractum and hydrogel matrix mix grind well, and get compound; Then with PEG400, oil bath is heated to 95 ℃ of meltings, add in the compound, and mixing, and get final product.
The above medicine, wherein:
The Pseudobulbus Bletillae (Rhizoma Bletillae): claim again Pseudobulbus Bletillae (Rhizoma Bletillae), choose decontamination, be soaked in water, pull out, dry in the air suitable to humidity, section, drying, function: tonifying the lung, hemostasis, detumescence, granulation promoting, sore cures mainly lung and hinders hemoptysis, epistaxis, incised wound is hemorrhage, swollen ulcer drug, ulcer pain;
Rhizoma Corydalis claims again Rhizoma Corydalis, removes impurity, cleaning, drying, coarse crushing; Function: invigorate blood circulation circulation of qi promoting, the effect of pain relieving.Cure mainly all pains of trusted subordinate, colic, extremity stasis pain;
Borneolum Syntheticum: the master contains volatile oil, L-Borneol, eucalyptole etc.; Function: the refreshment of having one's ideas straightened out, clearing away heat to alleviate pain cures mainly the calentura coma, convulsion is fainted, the apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, the attacked by pestiferous factors stupor, conjunctival congestion, aphtha, laryngopharynx swelling and pain, auditory meatus is suppurated;
Herba Lysimachiae: remove earth, clean, dry; Function: heat clearing away, diuresis, antitussive, detumescence, detoxifcation cures mainly jaundice, edema, vesical calculus, malaria, rheumatic arthralgia;
Olibanum: choose the sub-impurity of shakeout; Function: regulating qi and activating blood, analgesic therapy is controlled coagulation of QI-blood, trusted subordinate's pain, the carbuncle pyogenic infections from tumour or sore;
Myrrha: choose decontamination, break into fragment, function: loose blood blood stasis removing, subduing swelling and relieving pain cures mainly all Tong ， of trusted subordinate mass in the abdomen, ulcer sore pain;
Pseudobulbus cremastrae seu pleiones: eliminate fibrous root, clean, clear water soaked 2～4 hours, and taking-up runs through, and section is dried; Function: detumescence, eliminating stagnation is reduced phlegm, and detoxifcation cures mainly the carbuncle furuncle swollen, scrofula, sore throat swells and ache;
Spina Gleditsiae: claiming again Spina Gleditsiae, is the Spina jujubae on the pulse family deciduous tree Fructus Gleditsia branch, chooses decontamination, is soaked in water, and runs through rear section, dries; Function: the pus of sterilizing, search wind, cure mainly swollen ulcer drug; Scrofula; Skin ulcer rash stubborn dermatitis;
Semen Coicis: remove cot and impurity, sieve dedust bits, function: inducing diuresis to remove edema, eliminating dampness by diuresis, spleen invigorating, Chu Paralysis, clearing away heat and discharging pus; Cure mainly the carbuncle furuncle swollen, scrofula, sore throat swells and ache;
Hydrogel matrix: character is soft, and the water blockoff that is applicable in defervescence plaster used, pain easing plaster, agricultural film, conditioning agent, the petrochemical industry is adjusted the antistaling agent in the food, thickening agent, the pharmaceutical carrier in the medical treatment etc.;
Glycerol: the another name glycerol, the analysis, solvent, the tolerance that are applicable to aqueous solution are taken into account hydraulic press bradyseism liquid, softening agent, antibiotic fermentation nutrient, desiccant, lubricant, pharmaceuticals industry;
PEG400: be colourless or almost colourless thick liquid; Slightly little smelly, be applicable to plasticizer, softening agent, humidizer, and be used for pharmacy cream and medicine.
The present invention is directed to the cholecystitis basic pathology and be the stagnation of QI, blood stasis, the excess pathogen impatency side of body flank passages through which vital energy circulates such as damp and hot, therefore adopting heat clearing and blood circulation promoting, regulating QI to relieve pain is main method for the treatment of, collection medicine and the meridians combined effect of invigorating blood circulation, stimulate the menstrual flow, regulating the flow of vital energy, the heat clearing away of invigorating blood circulation, regulating QI to relieve pain make through ruton and hypochondriac pain only.The present invention is applied to the clinical good effect of receiving, concrete clinical data of the present invention is as follows:
One, diagnostic criteria
Have acute or the chronic cholecystitis medical history; Upper abdomen or right flank position feeling of distension and oppression discomfort or dull pain, pain is back or right omoplate district radiation to the right sometimes, and abdominal distention after meal, belch, nauseating, dyspepsia are more obvious after the greasy food of oil-feed especially; Gallbladder area has tenderness, and Murphy's sign is positive; Gallbladder size, form, wall thickness, wall smoothness and bile entrant sound are observed in the gall bladder B mode ultrasound imaging inspection; Chronic cholecystitis symptom and diagnostic sign and gall bladder B mode ultrasound imaging check that weight classification and the score standard document that sees reference gets rid of cholelithiasis, liver cirrhosis, severe cardiac disease of ZANG-organs and patients with hypertension are arranged.
Two, clinical data
Observe altogether treatment 320 examples, be outpatient service and inpatient.Be divided at random two groups: in treatment group 160 examples, male 90 examples, women 70 examples; 20-62 years old ages, average 37.1 years old; The course of disease 3～7 years, average 4.1 years; In matched group 160 examples, male 88 examples, women 72 examples; 18-62 years old ages, average 40.1 years old; The course of disease 2 ~ 7 years, average 4.5 years.Two groups of sexes, age, medical history no significant difference (
P〉0.05), have comparability.
Two, therapeutic scheme
1, matched group: each 4 of oral DANNING PIAN (with the xanthate industry), oral every day 3 times, be 2 weeks the course for the treatment of;
2, treatment group: add on the matched group basis that to use ointment of the present invention, the course for the treatment of be 2 weeks;
1. master point: Ashi point, knee joint four, gallbladder cave.Adjunct acupuncture points: Qimen, gb 34, Guan Yuan;
When 2. using, ointment of the present invention is put into the middle band of material of non-woven fabrics adhesive plaster, fill band of material, the ointment surface is flushed with band of material, medicine is aimed at the acupuncture point, fix the non-woven fabrics adhesive plaster, the one-tenth diameter is 5cm, and thickness is the circular patch of 1-2cm approximately, and master point and adjunct acupuncture points acupuncture point respectively one stick, 12h changes once, the part occurs such as the patient and burns pain or erythra and in time remove and apply ointment or plaster.
Three, efficacy assessment standard
Cure: clinical symptoms and sign disappear, and the ultrasound diagnosis gallbladder is normal, follow up a case by regular visits to not recurrence in 1 year;
Produce effects: clinical symptoms and sign obviously alleviate, and the ultrasound diagnosis gallbladder inflammation obviously alleviates;
Effectively: clinical symptoms and sign take a favorable turn, and attack times reduces;
Invalid: clinical symptoms and sign, ultrasound diagnosis are all without changing.
Four, statistical procedures
Use SPSS statistics software data processing, measurement data is checked with t, enumeration data x
2Check,
P＜0.05 expression difference has statistical significance.
Five, result
The table 1 liang clinical comparison of group
| Grouping | ｎ | Cure | Produce effects | Effectively | Invalid | Total effective rate |
| Treatment group | 160 | 42 * | 88 | 29 | 1 | 99.3% * |
| Matched group | 160 | 12 | 68 | 49 | 31 | 80.6% |
Annotate: compare with matched group
* P＜0.05
B ultrasonic changes (example) before and after the table 2 liang group patient treatment
| Grouping | ? | Normally | Gently | In | Heavy |
| Treatment group | Before the treatment | 0 | 71 | 48 | 41 |
| ? | After the treatment | 42 ▲ | 51 | 31 | 36 |
| Matched group | Before the treatment | 0 | 69 | 50 | 41 |
| ? | After the treatment | 12 | 61 | 40 | 47 |
With comparison after the treatment of control group
▲ P＜0.05
Five, conclusion
Cholecystitis is many to be delayed due to the outbreak repeatedly by chronic infection, chemical stimulation and acute cholecystitis.Can show as the symptoms such as epigastrium dull pain, dyspepsia clinically.Chronic cholecystitis belongs to motherland's medical science hypochondriac pain category.Motherland's medical science thinks, primary disease is many to cause liver and gall pent-up, functional activity of QI being not smooth because eating and drinking without temperance, feelings will are uncomfortable, courage is unfavorable causes.The clinical treatment cholecystitis is often taked traditional function of gallbladder promoting and anti-inflammatory treatment, though can improve clinical symptoms and sign, the Histological change of gallbladder chronic inflammatory disease is relatively poor, and easily repeatedly outbreak, and the sickness rate of formation cholelithiasis is higher.
According to Chinese medicine meridian theory, viscera theory, meridians Yu cave theory, can make the rhythmic contraction of gallbladder, bile duct and sphincter diastole thereof in conjunction with local excitation, with function of gallbladder promoting, antiinflammatory, pain relieving, and pathological tissues is in time recovered.Reuse the pain relieving of Rhizoma Corydalis depressed liver-energy dispersing and QI regulating in the side; Pseudobulbus cremastrae seu pleiones, Myrrha, the pain relieving of Olibanum blood stasis-eliminating and stagnation-dissipating; Spina Gleditsiae, the pain relieving of Semen Coicis detoxicating and resolving stagnation of pathogens, Borneolum Syntheticum, the Pseudobulbus Bletillae (Rhizoma Bletillae), the pain relieving of Herba Lysimachiae clearing away heat and cooling blood.Full side altogether the long memorial liver, regulate the flow of vital energy, the effect of blood stasis dispelling, suit not bitterly understanding of traditional Chinese medical science general rule, meet the basic pathology of cholecystitis.While medicament plaster acupuncture point, scalable meridian qi and blood and relevant internal organs pass through local penetration, discharge medicine and play a role, meet the mechanism of the traditional Chinese medical science " inner disease outer treat ", curative effect is sure, actual clinical meaning is arranged, and is this sick comparatively ideal medicine of a kind for the treatment of, and economic and social benefit is huge.
Claims (5)
1. treat the right flank distension that acute and chronic cholecystitis causes, the ointment of pain for one kind, it is characterized in that, made as raw material by Pseudobulbus Bletillae (Rhizoma Bletillae) 5-15g, Rhizoma Corydalis 5-15g, Borneolum Syntheticum 3-7g, Herba Lysimachiae 5-15g, Olibanum 5-15g, Myrrha 5-15g, Pseudobulbus cremastrae seu pleiones 3-7g, Spina Gleditsiae 5-15g, Semen Coicis 5-15g, hydrogel matrix 3-5g, glycerol 0.5-1ml and PEG400 1-1.5g, wherein: the 1) preparation of hydrogel matrix: carbopol 940 3g are added in the 30ml distilled water, swelling, add again ethyl hydroxybenzoate 0.05g and azone 3.6ml, stir; 2) Pseudobulbus Bletillae (Rhizoma Bletillae) powder is broken into fine powder, crosses 200 mesh sieves, get Pseudobulbus Bletillae (Rhizoma Bletillae) powder; Olibanum and Myrrha mix, be ground into granule, add Olibanum and Myrrha weight and 8 times of water gagings, distilled 6 hours, collect volatile oil, medical filtration gets filtering solution, and is for subsequent use, medicinal residues and Rhizoma Corydalis and Semen Coicis merge, get hybrid medicine, hybrid medicine adds Olibanum at every turn, Myrrha, the mass concentration of Rhizoma Corydalis and Semen Coicis weight and 6 times of amounts is 85% ethanol, reflux, extract, 2 times, each 1.5 hours, filter merging filtrate, decompression recycling ethanol, get mixed liquor, Pseudobulbus cremastrae seu pleiones, Spina Gleditsiae and Herba Lysimachiae add Pseudobulbus cremastrae seu pleiones at every turn, Spina Gleditsiae and Herba Lysimachiae weight and 8 times of water gagings, decoct each 1.5 hours 2 times, filter, merging filtrate, and merge with filtering solution and mixed liquor behind the above-mentioned collection volatile oil, be evaporated to 60 ℃ of thick extractum of measuring relative density 1.2-1.3; 3) get Pseudobulbus Bletillae (Rhizoma Bletillae) powder, add glycerol, ground 8-10 minute, Pseudobulbus Bletillae (Rhizoma Bletillae) cream, it is 95% dissolve with ethanol that Borneolum Syntheticum adds mass concentration, gets lysate, volatile oil adds polyoxyethylene sorbitan monoleate 0.2g and grinds well, Pseudobulbus Bletillae (Rhizoma Bletillae) cream, lysate and add volatile oil that polyoxyethylene sorbitan monoleate 0.2g grinds well and thick extractum and hydrogel matrix mix grind well, and get compound; Then with PEG400, oil bath is heated to 90-100 ℃ of melting, adds in the compound mixing.
2. the right flank distension that causes of the acute and chronic cholecystitis for the treatment of according to claim 1, the ointment of pain, it is characterized in that, made as raw material by Pseudobulbus Bletillae (Rhizoma Bletillae) 10g, Rhizoma Corydalis 10g, Borneolum Syntheticum 5g, Herba Lysimachiae 10g, Olibanum 5g, Myrrha 5g, Pseudobulbus cremastrae seu pleiones 5g, Spina Gleditsiae 10g, Semen Coicis 5g, hydrogel matrix 5g, glycerol 1ml and PEG400 1.5g, wherein: the 1) preparation of hydrogel matrix: carbopol 940 3g are added in the 30ml distilled water, swelling, add again ethyl hydroxybenzoate 0.05g and azone 3.6ml, stir; 2) Pseudobulbus Bletillae (Rhizoma Bletillae) powder is broken into fine powder, crosses 200 mesh sieves, get Pseudobulbus Bletillae (Rhizoma Bletillae) powder; Olibanum and Myrrha mix, be ground into granule, add Olibanum and Myrrha weight and 8 times of water gagings, distilled 6 hours, collect volatile oil, medical filtration gets filtering solution, and is for subsequent use, medicinal residues and Rhizoma Corydalis and Semen Coicis merge, get hybrid medicine, hybrid medicine adds Olibanum at every turn, Myrrha, the mass concentration of Rhizoma Corydalis and Semen Coicis weight and 6 times of amounts is 85% ethanol, reflux, extract, 2 times, each 1.5 hours, filter merging filtrate, decompression recycling ethanol, get mixed liquor, Pseudobulbus cremastrae seu pleiones, Spina Gleditsiae and Herba Lysimachiae add Pseudobulbus cremastrae seu pleiones at every turn, Spina Gleditsiae and Herba Lysimachiae weight and 8 times of water gagings, decoct each 1.5 hours 2 times, filter, merging filtrate, and merge with filtering solution and mixed liquor behind the above-mentioned collection volatile oil, be evaporated to 60 ℃ of thick extractum of measuring relative densities 1.2; 3) get Pseudobulbus Bletillae (Rhizoma Bletillae) powder, add glycerol, ground 9 minutes, Pseudobulbus Bletillae (Rhizoma Bletillae) cream, it is 95% dissolve with ethanol that Borneolum Syntheticum adds mass concentration, gets lysate, volatile oil adds polyoxyethylene sorbitan monoleate 0.2g and grinds well, Pseudobulbus Bletillae (Rhizoma Bletillae) cream, lysate and add volatile oil that polyoxyethylene sorbitan monoleate 0.2g grinds well and thick extractum and hydrogel matrix mix grind well, and get compound; Then with PEG400, oil bath is heated to 95 ℃ of meltings, adds in the compound mixing.
3. the right flank distension that causes of the acute and chronic cholecystitis for the treatment of according to claim 1, the ointment of pain, it is characterized in that, made as raw material by Pseudobulbus Bletillae (Rhizoma Bletillae) 5g, Rhizoma Corydalis 5g, Borneolum Syntheticum 3g, Herba Lysimachiae 5g, Olibanum 5g, Myrrha 5g, Pseudobulbus cremastrae seu pleiones 3g, Spina Gleditsiae 5g, Semen Coicis 5g, hydrogel matrix 3g, glycerol 0.5ml and PEG400 1g, wherein: the 1) preparation of hydrogel matrix: carbopol 940 3g are added in the 30ml distilled water, swelling, add again ethyl hydroxybenzoate 0.05g and azone 3.6ml, stir; 2) Pseudobulbus Bletillae (Rhizoma Bletillae) powder is broken into fine powder, crosses 200 mesh sieves, get Pseudobulbus Bletillae (Rhizoma Bletillae) powder; Olibanum and Myrrha mix, be ground into granule, add Olibanum and Myrrha weight and 8 times of water gagings, distilled 6 hours, collect volatile oil, medical filtration gets filtering solution, and is for subsequent use, medicinal residues and Rhizoma Corydalis and Semen Coicis merge, get hybrid medicine, hybrid medicine adds Olibanum at every turn, Myrrha, the mass concentration of Rhizoma Corydalis and Semen Coicis weight and 6 times of amounts is 85% ethanol, reflux, extract, 2 times, each 1.5 hours, filter merging filtrate, decompression recycling ethanol, get mixed liquor, Pseudobulbus cremastrae seu pleiones, Spina Gleditsiae and Herba Lysimachiae add Pseudobulbus cremastrae seu pleiones at every turn, Spina Gleditsiae and Herba Lysimachiae weight and 8 times of water gagings, decoct each 1.5 hours 2 times, filter, merging filtrate, and merge with filtering solution and mixed liquor behind the above-mentioned collection volatile oil, be evaporated to 60 ℃ of thick extractum of measuring relative densities 1.3; 3) get Pseudobulbus Bletillae (Rhizoma Bletillae) powder, add glycerol, ground 8 minutes, Pseudobulbus Bletillae (Rhizoma Bletillae) cream, it is 95% dissolve with ethanol that Borneolum Syntheticum adds mass concentration, gets lysate, volatile oil adds polyoxyethylene sorbitan monoleate 0.2g and grinds well, Pseudobulbus Bletillae (Rhizoma Bletillae) cream, lysate and add volatile oil that polyoxyethylene sorbitan monoleate 0.2g grinds well and thick extractum and hydrogel matrix mix grind well, and get compound; Then with PEG400, oil bath is heated to 90 ℃ of meltings, adds in the compound mixing.
4. the right flank distension that causes of the acute and chronic cholecystitis for the treatment of according to claim 1, the ointment of pain, it is characterized in that, made as raw material by Pseudobulbus Bletillae (Rhizoma Bletillae) 15g, Rhizoma Corydalis 15g, Borneolum Syntheticum 7g, Herba Lysimachiae 15g, Olibanum 15g, Myrrha 15g, Pseudobulbus cremastrae seu pleiones 7g, Spina Gleditsiae 15g, Semen Coicis 15g, hydrogel matrix 5g, glycerol 1ml and PEG400 1.5g, wherein: the 1) preparation of hydrogel matrix: carbopol 940 3g are added in the 30ml distilled water, swelling, add again ethyl hydroxybenzoate 0.05g and azone 3.6ml, stir; 2) Pseudobulbus Bletillae (Rhizoma Bletillae) powder is broken into fine powder, crosses 200 mesh sieves, get Pseudobulbus Bletillae (Rhizoma Bletillae) powder; Olibanum and Myrrha mix, be ground into granule, add Olibanum and Myrrha weight and 8 times of water gagings, distilled 6 hours, collect volatile oil, medical filtration gets filtering solution, and is for subsequent use, medicinal residues and Rhizoma Corydalis and Semen Coicis merge, get hybrid medicine, hybrid medicine adds Olibanum at every turn, Myrrha, the mass concentration of Rhizoma Corydalis and Semen Coicis weight and 6 times of amounts is 85% ethanol, reflux, extract, 2 times, each 1.5 hours, filter merging filtrate, decompression recycling ethanol, get mixed liquor, Pseudobulbus cremastrae seu pleiones, Spina Gleditsiae and Herba Lysimachiae add Pseudobulbus cremastrae seu pleiones at every turn, Spina Gleditsiae and Herba Lysimachiae weight and 8 times of water gagings, decoct each 1.5 hours 2 times, filter, merging filtrate, and merge with filtering solution and mixed liquor behind the above-mentioned collection volatile oil, be evaporated to 60 ℃ of thick extractum of measuring relative densities 1.3; 3) get Pseudobulbus Bletillae (Rhizoma Bletillae) powder, add glycerol, ground 10 minutes, Pseudobulbus Bletillae (Rhizoma Bletillae) cream, it is 95% dissolve with ethanol that Borneolum Syntheticum adds mass concentration, gets lysate, volatile oil adds polyoxyethylene sorbitan monoleate 0.2g and grinds well, Pseudobulbus Bletillae (Rhizoma Bletillae) cream, lysate and add volatile oil that polyoxyethylene sorbitan monoleate 0.2g grinds well and thick extractum and hydrogel matrix mix grind well, and get compound; Then with PEG400, oil bath is heated to 100 ℃ of meltings, adds in the compound mixing.
5. the right flank distension that causes of the acute and chronic cholecystitis for the treatment of according to claim 1, the ointment of pain, it is characterized in that, made as raw material by Pseudobulbus Bletillae (Rhizoma Bletillae) 10g, Rhizoma Corydalis 10g, Borneolum Syntheticum 5g, Herba Lysimachiae 10g, Olibanum 10g, Myrrha 10g, Pseudobulbus cremastrae seu pleiones 5g, Spina Gleditsiae 10g, Semen Coicis 10g, hydrogel matrix 4g, glycerol 0.8ml and PEG400 1.3g, wherein: the 1) preparation of hydrogel matrix: carbopol 940 3g are added in the 30ml distilled water, swelling, add again ethyl hydroxybenzoate 0.05g and azone 3.6ml, stir; 2) Pseudobulbus Bletillae (Rhizoma Bletillae) powder is broken into fine powder, crosses 200 mesh sieves, get Pseudobulbus Bletillae (Rhizoma Bletillae) powder; Olibanum and Myrrha mix, be ground into granule, add Olibanum and Myrrha weight and 8 times of water gagings, distilled 6 hours, collect volatile oil, medical filtration gets filtering solution, and is for subsequent use, medicinal residues and Rhizoma Corydalis and Semen Coicis merge, get hybrid medicine, hybrid medicine adds Olibanum at every turn, Myrrha, the mass concentration of Rhizoma Corydalis and Semen Coicis weight and 6 times of amounts is 85% ethanol, reflux, extract, 2 times, each 1.5 hours, filter merging filtrate, decompression recycling ethanol, get mixed liquor, Pseudobulbus cremastrae seu pleiones, Spina Gleditsiae and Herba Lysimachiae add Pseudobulbus cremastrae seu pleiones at every turn, Spina Gleditsiae and Herba Lysimachiae weight and 8 times of water gagings, decoct each 1.5 hours 2 times, filter, merging filtrate, and merge with filtering solution and mixed liquor behind the above-mentioned collection volatile oil, be evaporated to 60 ℃ of thick extractum of measuring relative densities 1.3; 3) get Pseudobulbus Bletillae (Rhizoma Bletillae) powder, add glycerol, ground 9 minutes, Pseudobulbus Bletillae (Rhizoma Bletillae) cream, it is 95% dissolve with ethanol that Borneolum Syntheticum adds mass concentration, gets lysate, volatile oil adds polyoxyethylene sorbitan monoleate 0.2g and grinds well, Pseudobulbus Bletillae (Rhizoma Bletillae) cream, lysate and add volatile oil that polyoxyethylene sorbitan monoleate 0.2g grinds well and thick extractum and hydrogel matrix mix grind well, and get compound; Then with PEG400, oil bath is heated to 95 ℃ of meltings, adds in the compound mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110362407 CN102357215B (en) | 2011-11-16 | 2011-11-16 | Ointment for treating right hypochondriac distention and pain caused by acute and chronic cholecystitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110362407 CN102357215B (en) | 2011-11-16 | 2011-11-16 | Ointment for treating right hypochondriac distention and pain caused by acute and chronic cholecystitis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102357215A CN102357215A (en) | 2012-02-22 |
| CN102357215B true CN102357215B (en) | 2013-01-02 |
Family
ID=45582632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110362407 Expired - Fee Related CN102357215B (en) | 2011-11-16 | 2011-11-16 | Ointment for treating right hypochondriac distention and pain caused by acute and chronic cholecystitis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102357215B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9480747B2 (en) * | 2012-01-24 | 2016-11-01 | Bvw Holding Ag | Class of anti-adhesion hydrogels with healing aspects |
| CN103536876B (en) * | 2012-12-03 | 2015-09-09 | 杨燕 | A kind of preparation method for the treatment of the Chinese medicine composition of acute cholecystitis |
| CN106074730A (en) * | 2016-07-29 | 2016-11-09 | 河南中医学院 | A kind of ointment treating cirrhotic ascites and preparation method thereof |
Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1106678A (en) * | 1994-08-23 | 1995-08-16 | 路良宇 | Medicine for treatment of gastroenteritis and gastroenteritic ulcer and preparing process thereof |
| CN1476884A (en) * | 2003-07-09 | 2004-02-25 | 大连鸿宇药业有限公司 | Inflammation-relieving plaster and its production method |
| CN1537599A (en) * | 2003-04-20 | 2004-10-20 | 毛友昌 | Danshi Tongli granule for discharging biliary calculus, and its prepn. method |
| CN1857672A (en) * | 2006-03-08 | 2006-11-08 | 江西青春康源制药有限公司 | Cholelithiasis treating Danshitongli tablet and its preparing method |
| CN1935237A (en) * | 2005-09-23 | 2007-03-28 | 吕程 | Emplastrum for injury, bone, flatulence relieving and inflammation and its use |
| CN101049349A (en) * | 2006-04-03 | 2007-10-10 | 北京因科瑞斯生物制品研究所 | Chinese traditional medicine preparation in use for treating liver and gall disease, and preparation method |
| CN101066421A (en) * | 2007-05-21 | 2007-11-07 | 李君� | Plaster for treating cholecystitis, cholangitis and bile gastritis |
| CN101229268A (en) * | 2007-07-27 | 2008-07-30 | 黄素文 | Retinervus-smoothing regeneration ointment |
| CN101584767A (en) * | 2009-06-16 | 2009-11-25 | 林艳 | Compound traditional Chinese medicine ointment for treating acute cholecystitis |
| CN101698066A (en) * | 2009-11-05 | 2010-04-28 | 广西万通制药有限公司 | Chinese medicine preparation capable of diminishing inflammation, relieving pains, resisting bacteria, expelling stone and benefiting gallbladder, and preparation method and applications thereof |
| CN101766718A (en) * | 2008-12-26 | 2010-07-07 | 北京天科仁祥医药科技有限公司 | Drug combination for treating chronic cholecystitis and preparation method thereof |
| CN102188665A (en) * | 2010-03-18 | 2011-09-21 | 山东步长制药有限公司 | Application of medicinal composition in preparation of medicaments for treating alimentary system inflammation diseases |
| CN102188671A (en) * | 2011-06-01 | 2011-09-21 | 山东省中医药研究院 | Chinese medicinal preparation for treating chronic cholecystitis |
-
2011
- 2011-11-16 CN CN 201110362407 patent/CN102357215B/en not_active Expired - Fee Related
Patent Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1106678A (en) * | 1994-08-23 | 1995-08-16 | 路良宇 | Medicine for treatment of gastroenteritis and gastroenteritic ulcer and preparing process thereof |
| CN1537599A (en) * | 2003-04-20 | 2004-10-20 | 毛友昌 | Danshi Tongli granule for discharging biliary calculus, and its prepn. method |
| CN1476884A (en) * | 2003-07-09 | 2004-02-25 | 大连鸿宇药业有限公司 | Inflammation-relieving plaster and its production method |
| CN1935237A (en) * | 2005-09-23 | 2007-03-28 | 吕程 | Emplastrum for injury, bone, flatulence relieving and inflammation and its use |
| CN1857672A (en) * | 2006-03-08 | 2006-11-08 | 江西青春康源制药有限公司 | Cholelithiasis treating Danshitongli tablet and its preparing method |
| CN101049349A (en) * | 2006-04-03 | 2007-10-10 | 北京因科瑞斯生物制品研究所 | Chinese traditional medicine preparation in use for treating liver and gall disease, and preparation method |
| CN101066421A (en) * | 2007-05-21 | 2007-11-07 | 李君� | Plaster for treating cholecystitis, cholangitis and bile gastritis |
| CN101229268A (en) * | 2007-07-27 | 2008-07-30 | 黄素文 | Retinervus-smoothing regeneration ointment |
| CN101766718A (en) * | 2008-12-26 | 2010-07-07 | 北京天科仁祥医药科技有限公司 | Drug combination for treating chronic cholecystitis and preparation method thereof |
| CN101584767A (en) * | 2009-06-16 | 2009-11-25 | 林艳 | Compound traditional Chinese medicine ointment for treating acute cholecystitis |
| CN101698066A (en) * | 2009-11-05 | 2010-04-28 | 广西万通制药有限公司 | Chinese medicine preparation capable of diminishing inflammation, relieving pains, resisting bacteria, expelling stone and benefiting gallbladder, and preparation method and applications thereof |
| CN102188665A (en) * | 2010-03-18 | 2011-09-21 | 山东步长制药有限公司 | Application of medicinal composition in preparation of medicaments for treating alimentary system inflammation diseases |
| CN102188671A (en) * | 2011-06-01 | 2011-09-21 | 山东省中医药研究院 | Chinese medicinal preparation for treating chronic cholecystitis |
Non-Patent Citations (6)
| Title |
|---|
| "消炎止痛膏外用四则";黄朝阳等;《中国民间疗法》;20040531;第12 卷(第5 期);26 * |
| "穴位贴敷治疗慢性胆囊炎急性发作200 例疗效观察";阴建军;《新中医》;20101130;第42 卷(第11 期);97-98 * |
| "胁痛膏贴敷治疗慢性胆囊炎56例";张 军;《中医外治杂志》;20061031;第15卷(第5期);39 * |
| 张 军."胁痛膏贴敷治疗慢性胆囊炎56例".《中医外治杂志》.2006,第15卷(第5期), |
| 阴建军."穴位贴敷治疗慢性胆囊炎急性发作200 例疗效观察".《新中医》.2010,第42 卷(第11 期), |
| 黄朝阳等."消炎止痛膏外用四则".《中国民间疗法》.2004,第12 卷(第5 期),26. |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102357215A (en) | 2012-02-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102302565B (en) | Stasis eliminating powder for treating soft tissue injury and cervical spondylosis | |
| CN1190217C (en) | Medicine for treating dematosis | |
| CN103316315B (en) | Cooling paste | |
| CN104623331A (en) | Traditional Chinese medicine preparation for treating migraine | |
| CN102357215B (en) | Ointment for treating right hypochondriac distention and pain caused by acute and chronic cholecystitis | |
| CN102178817B (en) | Chinese medicinal composition for treating multiple lipomas | |
| CN104524247B (en) | One treats migrainous medical composition and its use | |
| CN102716210A (en) | Traditional Chinese medicine for treating rheumatism and production method thereof | |
| CN102166272B (en) | Medicament for treating hemorrhoids and preparation method thereof | |
| CN101703655B (en) | Chinese medicinal linimentum for treating psoriasis | |
| CN103705632A (en) | Application of mammary aggregation dispersing tablets in preparation of medicines for treating penis hardening disease | |
| CN103877462A (en) | External liniment for treating psoriasis and preparation method thereof | |
| CN101085046A (en) | External-applied medicine for treating pruritus skin diseases and its preparation method | |
| CN103920076A (en) | Traditional Chinese medicine for treating tinea of feet and hands as well as eczema | |
| CN102652772A (en) | Chinese herbal medicine pill for treating psoriasis and neurodermatitis | |
| CN102727801B (en) | Orally-taken traditional Chinese drug for treating psoriasis vulgaris | |
| CN103585273B (en) | Traditional Chinese medicine composition for treating local swelling and pain | |
| CN102266435A (en) | Traditional Chinese medicine for treating psoriasis | |
| CN105079332A (en) | Traditional Chinese medicine composition for treating perianal abscess caused by fire toxin accumulation | |
| CN104127827A (en) | Traditional Chinese medicine for treating biliary calculi | |
| CN101554432B (en) | Fumigating and washing medicine for curing hemorrhoids | |
| CN104523942B (en) | One treats colpitic external preparation | |
| CN101732606B (en) | Oral medicinal composition for treating psoriasis | |
| CN101607069B (en) | Chinese traditional medicine for treating phlebitis, old lower extremity venous ulcer and venous purpura disease | |
| CN102846750A (en) | Fengtongning composite preparation and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130102 Termination date: 20131116 |