CN101049349A - Chinese traditional medicine preparation in use for treating liver and gall disease, and preparation method - Google Patents
Chinese traditional medicine preparation in use for treating liver and gall disease, and preparation method Download PDFInfo
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Abstract
A Chinese medicine for treating hepatobiliary diseases, such as acute or chronic cholecystitis, biliary tract infection and cholelithiasis, is prepared from 8 raw materials including artificial bezoar, silymarinum, rhubarb, dandelion herb, etc. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation that is used for liver and gall diseases and preparation method thereof, belong to technical field of Chinese medicine.
Technical background
Cholelithiasis such as cholelithiasis, cholecystitis is current frequently-occurring disease, commonly encountered diseases, and often follows generation, is one of China's common frdquently encountered disease.Raising along with living standards of the people, the ratio that high-cholesterol diet is taken in the diet obviously increases, bile cholesterol concentration increases or hypersaturated state makes cholesterol be easy to separate out and form calculus, so the sickness rate of diseases such as cholecystitis and cholelithiasis has the trend of continuous rising.Show according to interrelated data: cholelithiasis is 1%-10% at China nature crowd's sickness rate.With age, sickness rate obviously increases, and reaches the peak to morbidity in 45 years old, and the people's sickness rate more than 60 years old is 28%.The men and women all can fall ill, and the women is more than the male, and M-F is 1: 3～1: 4.Cholelithiasis accounts for the 3rd or the 4th in China's acute abdomen morbidity.Though therapeutic modality is various at present, Chinese medicine is more and more brought into play significant effect in this field.
Cholelithiasis belongs to the traditional Chinese medical science " hypochondriac pain ", " blocked-up chest ", " jaundice " category more.The traditional Chinese medical science is thought the gallbladder being attached to the liver, with liver the exterior and the interior mutually, liver and gallbladder close relation on meridians.Liver property bar reaches, main catharsis, bile be " borrow gas after the liver; overflow in gallbladder; gather form ", gallbladder be " fu-viscera with clear juice ", its function is suitable to lead to the behavior of falling, all feelings will is not smooth, cold temperature is uncomfortable, and eating and drinking without temperance, surfeit is greasy or malnutrition due to parasitic infestation etc. all can cause QI stagnation of the liver and galibladder, damp and hot heap soil or fertilizer over and around the roots resistance, influence catharsis and cholic logical the falling of liver, make bile excretion not smooth.Order tired out in long-pending month, experienced all sorts of decocting, and was agglomerated into stone.DANNING PIAN merit master clearing away heat and eliminating dampness, depressed liver-energy dispersing and function of gallbladder promoting is mainly used in damp-heat type cholelithiasis such as acute and chronic cholecystitis, biliary tract infection, diseases such as cholelithiasis.Treatment.Since this medicine listing, because of its determined curative effect, no obvious toxic-side effects is subjected to numerous doctors and patients' welcome deeply, but because of said preparation is a coated tablet, art for coating is loaded down with trivial details, and finished product chaps, occurs mottle easily, and stability is bad, and the disintegration time of coated tablet is longer.Still this is further studied, be intended to clinical effective prescription is carried out more deep research, improve the quality of this medicine, better to benefit extensive patients.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine preparation that is used for liver and gall diseases and preparation method thereof, said preparation mainly is made up of artificial Calculus Bovis, silymarin, berberine hydrochloride, Rhizoma Corydalis, Radix Et Rhizoma Rhei, Herba Taraxaci, Herba Lysimachiae, Herba Menthae wet goods medicine; Have clearing away heat and eliminating dampness, the effect of depressed liver-energy dispersing and function of gallbladder promoting is used for acute and chronic cholecystitis, biliary tract infection, cholelithiasis etc.Artificial Calculus Bovis's nature and flavor bitter cold has heat-clearing and toxic substances removing in the side, the endogenous wind stopping relieving convulsion, and arresting convulsion function such as clear away heart-fire, modern pharmacological research proof artificial Calculus Bovis has effects such as analgesic calmness, antiinflammatory, antibiotic, antiviral and resisting pathogenic microbes; Berberine hydrochloride has heat-clearing and toxic substances removing, anti-inflammation, function of gallbladder promoting, blood pressure lowering and antipyretic effect, is the spectrum antimicrobial drug, and various bacteria is all had stronger inhibitory action, and two medicines share, and is total to main clearing away heat and eliminating dampness, the merit of detoxicating, relieving inflammation.Silymarin is natural flavanolignan's compounds, and pharmacological evaluation proves that it has significant protective effect to the hepar damnification that multiple hepatotoxic agent causes, can improve various hepatopaths' liver function, thereby has the hepatic cholagogic effect.Rhizoma Corydalis is hot without hesitation, warm, and bitter in the mouth is doublely gone into QI and blood, can promoting flow of QI and blood and blood stasis dispelling is used for multiple treatment of pain such as breast side of body gastral cavity abdomen.Radix Et Rhizoma Rhei can rush down the internal organs heat clearing away, and cholagogue and eliminating inflammation, modern study show that it has effects such as very strong analgesic, antibiotic, antiinflammatory, function of gallbladder promoting.Cold in nature, the sweet-bitter flavor of Herba Taraxaci, the effect that heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dampness removing jaundice eliminating are arranged, pharmacological research shows, Herba Taraxaci extract can increase the choleresis of anesthetized rat, have choleretic effect, help the recovery of liver function, reduce transaminase, decoct has tangible reduction serum paddy third transaminase and the effect that alleviates hepatic cell fattydegeneration to the hepatic injury due to the rat carbon tetrachloride, thereby is used for the treatment of diseases such as chronic gallbladder spasmolytic, calculosis and anicteric hepatitis clinically.Herba Lysimachiae property hardship, cold, sour in the mouth is gone into liver and gall kidney urinary bladder channel, the effect that clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling are arranged, merit is arrogated to oneself heat clearing away, diuretic, Tonglin Paishi, and modern study proves the bile secretion of its energy hepatocyte, and bile increases in the stones in intrahepatic bile duct, intrinsic pressure increasing, sphincter muscle of bile duct is lax, and bile is discharged, and can also make urine become acidity, and impel the litholysis that is present under the alkali condition, show that it has choleretic effect.Oleum menthae can increase the bile output, and lasting choleretic effect is arranged.Therefore, all medicines share, and play the effect of clearing heat secreting bile, purging FU-organs function of gallbladder promoting, antiinflammatory calculus altogether.This medicine is through clinical verification, and is evident in efficacy.For this reason, in order to enrich the dosage form kind, better bring into play the curative effect of this medicine, the applicant further studies it, developed the capsule of this medicine, not only kept the curative effect of former tablet preferably, and preparation technology is comparatively simple, disintegrate is also improved a lot than former preparation.
The present invention is achieved through the following technical solutions:
A kind of Chinese medicine preparation that is used for liver and gall diseases is characterized in that, it is mainly to be made up of active ingredient and/or adjuvant.Count by weight percentage, it is mainly to be made up of active ingredient 40-60% and adjuvant 60-40%.Calculate by weight, described active ingredient is mainly made by following raw materials according: 2.4 parts of artificial Calculus Boviss, 1.4 parts of silymarin, 1 part of berberine hydrochloride, 10 parts of Rhizoma Corydalis, 1 part of Radix Et Rhizoma Rhei, 12 parts of Herba Taraxacis, 16 parts of Herba Lysimachiaes, 0.16 part of Oleum menthae.
Described adjuvant includes but not limited to one or more in starch, dextrin, lactose, pregelatinized Starch, magnesium stearate, Pulvis Talci, the micropowder silica gel.
Preferred adjuvant is meant starch, micropowder silica gel.
Said preparation is preparation like this: get Rhizoma Corydalis, Radix Et Rhizoma Rhei is suitably pulverized, and makes solvent with 60% ethanol, floods to shine under fluid extract and the extractum item after 24 hours to carry out percolation, collects percolate, is concentrating below 70 ℃; Herba Taraxaci, Herba Lysimachiae decoct with water, and filter, and incorporate being condensed into the thick paste shape in the above-mentioned concentrated solution, dry, powder process after filtrate concentrates into; With artificial Calculus Bovis, silymarin, berberine hydrochloride mixing, add or do not add right amount of auxiliary materials again, granulate, drying sprays into Oleum menthae, and prepared becomes required preparation routinely.
Preferred preparation is a capsule.
This capsule is preparation like this: get Rhizoma Corydalis, Radix Et Rhizoma Rhei is suitably pulverized, and makes solvent with 60% ethanol, floods to shine under fluid extract and the extractum item after 24 hours to carry out percolation, collects percolate, is concentrating below 70 ℃; Herba Taraxaci, Herba Lysimachiae decoct with water 2-4 time, and amount of water 6-10 doubly measures, and decocting time 1.0-2.0 hour, filter, after concentrating, filtrate incorporates being condensed into the thick paste shape in the above-mentioned concentrated solution, dry, powder process into; With artificial Calculus Bovis, silymarin, berberine hydrochloride and right amount of auxiliary materials, mixing is granulated again, and drying sprays into Oleum menthae, and mixing incapsulates, promptly.
The preferred method for making of capsule is: get Rhizoma Corydalis, Radix Et Rhizoma Rhei is suitably pulverized, and makes solvent with 2 times of amount 60% ethanol, floods to shine under fluid extract and the extractum item after 24 hours and carries out percolation, collects percolate, is concentrating below 70 ℃; Herba Taraxaci, Herba Lysimachiae decoct with water 3 times, add 8 times of water gagings at every turn and decoct 1.5 hours, filter, and incorporate being condensed into the thick paste shape in the above-mentioned concentrated solution, dry, powder process after filtrate concentrates into; An amount of with artificial Calculus Bovis, silymarin, berberine hydrochloride and starch again, mixing is granulated, and drying sprays into Oleum menthae, adds 1.0% micropowder silica gel, and mixing incapsulates, promptly.
At prior art, former preparation determined curative effect is subjected to the welcome of doctor and patient deeply.But former coated tablet, art for coating is loaded down with trivial details, and finished product chaps, occurs mottle easily, and stability is bad, and disintegration time is longer.For this reason, the inventor carries out secondary development to it, has developed and has been developed to capsule, has both kept former preparation determined curative effect, and advantage easy to carry greatly provide disintegration time again, and preparation technology is simple.The present invention has carried out a large amount of tests to its supplementary product kind and consumption, the adjuvant of screening and principal agent reasonable mixture ratio, and technology is rationally feasible through lab scale, pilot scale, and is stable and controllable for quality, and suitable the amplification produces, and meets the modern requirement of Chinese medicine preparation.
The inventor has carried out a series of experiments, and is rationally feasible, stable and controllable for quality with proof technology of the present invention, to guarantee the beneficial effect of medicine.
Experimental example 1: extraction process examination
1, Rhizoma Corydalis, Radix Et Rhizoma Rhei percolation condition optimization
1.1 the alcohol adding amount optimization test during dipping
It is evenly moistening to add appropriate solvent before the medical material percolation, carry out percolation behind the airtight placement certain hour, alcohol adding amount when now flooding with regard to medical material carries out preferably, and concrete grammar and result are as follows: take by weighing Rhizoma Corydalis 125g, Radix Et Rhizoma Rhei 12.5g for a according to prescription, nominal is got three parts, be ground into coarse powder, 60% ethanol that adds 1,2,3 times of amount respectively floods after 24 hours and to filter, measure the volume of impregnation liquid, and the theoretical residual alcohol amount in the calculating medicinal residues, result such as following table.
Pure consumption preference data table during the table dipping
| Inventory (g) | 60% alcoholic acid addition (ml) | Dipping back gained alcohol liquid measure (ml) | Residual alcohol amount (ml) in the medicinal residues |
| 137.5 137.5 137.5 | 138 275 413 | 0 25 152 | 138 250 261 |
Show that according to The above results dipping back Rhizoma Corydalis, the residual alcohol amount of Radix Et Rhizoma Rhei medicinal residues are about 1.8 times of medical material amount, are 2 times of amounts of medical material so selection adds the amount of 60% alcohol dipping.
1.2 determining of percolation speed
Be percolation slowly during general medical material percolation, with reference to pertinent literature, the flow velocity when determining Rhizoma Corydalis and Radix Et Rhizoma Rhei percolation is per minute 1～3ml.
1.3 the screening of percolate volume
According to above-mentioned optimization test, determine pulverizing medicinal materials is become coarse powder, add 2 times of amount 60% alcohol dipping 24 hours, carry out percolation with the speed of per minute 1～3ml, existing volume to the collection percolate carries out optimization test.
Take by weighing Rhizoma Corydalis 125g, Radix Et Rhizoma Rhei 12.5g for a by prescription, be ground into coarse powder, add 2 times of amount 60% alcohol dipping after 24 hours, carry out percolation with the speed of per minute 1～3ml, every 100ml collects once, collects seven parts of continuous liquid of filtering altogether; With emodin and chrysophanol is evaluation index.
Almost do not had the chromatographic peak of emodin and chrysophanol to detect in the 6th part of continuous liquid of filtering of collection, illustrated that this moment, percolation was complete, the percolate of promptly collecting 500ml gets final product.This moment is complete in order to guarantee percolation, determines that the volume of collected percolate is about 550ml, promptly about 4 of the medical material total amount times of amounts.
In sum, the condition that can determine Rhizoma Corydalis and Radix Et Rhizoma Rhei percolation is: Rhizoma Corydalis, Radix Et Rhizoma Rhei powder are broken into coarse powder, add 2 times of amount 60% alcohol dipping and carry out percolation according under fluid extract and the extractum item with the speed of per minute 1～3ml after 24 hours, collect about 4 times of medical material amount percolates, promptly.
2, Herba Taraxaci, Herba Lysimachiae decocting condition are preferred
Because of the main component caffeic acid in the Herba Taraxaci is a water soluble ingredient, so be index with caffeinic total amount, the influence condition that decocting is boiled carries out preferably.
Take by weighing Herba Taraxaci 75g, Herba Lysimachiae 100g for a according to prescription, nominal is got nine parts, tests by the condition of factor level harmony in the exterior L9 (34) orthogonal table, get 9 dry extracts, according to high performance liquid chromatography, caffeic acid is carried out assay, measurement result is as follows.
Table caffeic acid measurement result tables of data
| Sample number | Inventory (g) | Paste volume (g) | Caffeic acid total amount (mg) |
| 1 2 3 4 5 6 7 8 9 | 175.0 175.0 175.0 175.0 175.0 175.0 175.0 175.0 175.0 | 12.2 14.1 13.2 15.3 17.6 14.1 17.5 15.7 17.1 | 2.80 4.58 4.24 4.88 4.98 4.43 3.60 3.98 4.47 |
Table water boiling and extraction technological factor water-glass
| Factor level | A (amount of water) | B (extraction time) | C (extraction time) |
| 1 2 3 | 6 times 8 | 1 hour 1.5 hours 2 hours | 2 times 3 times 4 times |
Table water boiling and extraction technology orthogonal test statistical table
| Tested number | The A amount of water | B extraction time | The C extraction time | The D blank | Caffeic acid total amount (mg) |
| 1 2 3 4 5 6 7 8 9 I II III SSj | 1 1 1 2 2 2 3 3 3 11.63 14.30 12.05 1.3752 | 1 2 3 1 2 3 1 2 3 11.28 13.55 13.15 0.9727 | 1 2 3 2 3 1 3 1 2 11.22 13.94 12.82 1.2514 | 1 2 3 3 1 2 2 3 1 12.26 12.62 13.10 0.1193 | 2.80 4.58 4.24 4.88 4.98 4.43 3.60 3.98 4.47 CT＝160.25 |
Table water boiling and extraction technology orthogonal test analysis of variance table
| Soruces of variation | Sum of deviation square | Degree of freedom | Variance | The F ratio | Significance |
| A B C D | 1.3752 0.9727 1.2514 0.1193 | 2 2 2 2 | 0.6876 0.4864 0.6257 0.0596 | 11.5318 8.1565 10.4935 |
*F
1-0.05(2，2)＝19.00 **F
1-0.01(2，2)＝99.00
The comprehensive The results of analysis of variance that goes up table, but master factor A, B, C there are no significant difference, so amount of water 6-10 times, decocting time 1-2 hour, decoct 2-4 time, all most of extracts active ingredients can be come out.But taking all factors into consideration, is A according to the selection process of producing actual decocting herbs
2B
2C
2, promptly decoct with water 3 times, add 8 times of water gagings at every turn, decocted 1.5 hours.
Experimental example 2 preparations shaping technical studies
1, the selection of filler
The diluent that Chinese medicine preparation is commonly used is starch, dextrin, lactose, pregelatinized Starch etc.Below it is tested, the result is as follows.
The screening of table filler kind
| Principal agent (g) | Starch (g) | Dextrin (g) | Lactose (g) | Pregelatinized Starch | Compressibility |
| 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 | 1.3 - - - 0.7 - 0.4 0.4 | - 1.3 - - - 0.5 0.4 0.25 | - - 1.3 - 0.6 - 0.3 0.25 | - - - 1.3 - 0.8 - 0.4 | Good general better better better |
Result of the test shows, no matter above-mentioned adjuvant uses separately still to mix is used, substantially can both molding, but test finds to use separately above-mentioned adjuvant gained granule compressibility, disintegrative all better, and the every index of the tablet that makes also meets the requirements.Higher because of lactose, dextrin price, starch not only price is low, and has disintegration, and from cost with produce and actually consider that preferred starch is a filler, its consumption is approximately suitable with principal agent, according to paste-forming rate, adds to total amount and gets final product.
2, the investigation of lubricant
Lubricant commonly used has magnesium stearate, micropowder silica gel, Pulvis Talci, according to trial test, above-mentioned any adjuvant or any and all the other one or more can both satisfy the preparation requirement when being used, but especially with micropowder silica gel for well, not only can increase particulate flowability, also have moisture-proof role.So preferred micropowder silica gel is a lubricant; According to the usual amounts of micropowder silica gel, its consumption is examined or check: the result is as follows below.
The table lubricant quantity is preferably shown
| Numbering | The consumption of micropowder silica gel (%) | The result | Angle of repose |
| 1 2 3 | 1.0 2.0 3.0 | The good mobility of particle of the general mobility of particle of mobility of particle is good | 38.2 31.5 31.1 |
According to above-mentioned result of the test, determine that the granule that the consumption of micropowder silica gel makes can both satisfy the preparation requirement between 1.0-3.0, to take all factors into consideration, the consumption of preferred micropowder silica gel is 2.0%.
3, method of granulating determines
Get dried cream powder, be divided into 3 parts, granulate, compare with Different concentrations of alcohol.Because of the medicated powder hygroscopicity is strong, has certain viscosity, so select the ethanol of high concentration to test (23 ℃ of room temperatures; Humidity 50%), its result such as following table.
Table granulating efficiency comparison sheet
| Sequence number | Concentration of alcohol (%) | Granulating efficiency |
| 1 2 3 | 90 95 dehydrated alcohol | Made soft material is more sticking, and the general made soft material of granulating efficiency is more sticking; The general made soft material soft durometer of grain forming effect is moderate; Grain forming is effective |
As seen from the above table, this granule used wetting agent of granulating is more than 95% ethanol, preferred dehydrated alcohol.
Experimental example 3: the mensuration of practical physical characteristics
1, the mensuration of mobility of particle
Whether satisfy the encapsulated requirement of production in order to investigate the particulate flowability that makes, so to measuring particulate angle of repose:
Adopt the fixed funnel method, with 3 funnel series connection, lowermost end is apart from horizontal positioned graph paper 1.5cm place, it is an amount of to get dried granule (water content is about 4%～5%), mixing is poured granule in the funnel of going up most carefully till the medicated powder cone tip that bottom funnel forms touches the funnel end opening along hopper walls, measured the diameter of conical base by graph paper, (tg α=H/R), the result is as follows to calculate angle of repose.
Show the granule mensuration of angle of repose
| Numbering | Angle of repose | x |
| 1 3 4 | 32.35 32.57 31.83 | 32.25 |
The result shows, the requirement of tabletting is satisfied in particulate angle of repose＜40 °.
2, the mensuration of granule critical relative humidity
Test method is as follows: it is an amount of to get granule, be ground into fine powder, after being dried to constant weight, get about 1g, the accurate title, decide, and is tiled in the weighing botle bottom that is dried to constant weight, accurately weighing is placed on the constant exsiccator of the formed relative humidity of supersaturated aqueous solution interior (the weighing bottle cap is opened) of the listed different salt of following table, in 25 ℃ of constant incubators, keep weighing after 48 hours, calculate the moisture absorption percentage rate.The result is as follows.
Particulate relative moisture absorption percentage rate (%) under the table different humidity
| The saturated salt solution kind | Relative humidity (%) | Moisture absorption percentage rate (%) |
| CH3COOK.1.5H2O MgCl2.6H2O K2CO3.2H2O NaBr.2H2O NaCl KCl KNO3 | 22.45 33.00 42.76 57.70 75.28 84.26 92.48 | 2.11 4.81 8.98 15.97 26.27 37.35 43.86 |
More than the hydroscopicity in the table is a vertical coordinate, and relative humidity (RH%) is the abscissa mapping, and figure sees Figure of description 1.
Accompanying drawing 1 explanation: the hydroscopicity in the above table is a vertical coordinate, and relative humidity (RH%) is mapped for abscissa, and accompanying drawing 1 shows, envionmental humidity is 73% when following, and particulate hydroscopicity is lower; And greater than 73%, hydroscopicity sharply increases.When packing was described, envionmental humidity should be controlled at below 73%.
Concrete embodiment
Embodiment 1:
Artificial Calculus Bovis 30g silymarin 17.5g berberine hydrochloride 12.5g Rhizoma Corydalis 125g
Radix Et Rhizoma Rhei 12.5g Herba Taraxaci 150g Herba Lysimachiae 200g Oleum menthae 2g
More than eight flavors, get Rhizoma Corydalis, Radix Et Rhizoma Rhei is suitably pulverized, and makes solvent with 2 times of amount 60% ethanol, flood after 24 hours according to (appendix IO of Chinese Pharmacopoeia version in 2005) under fluid extract and the extractum item and carries out percolation, the collection percolate is concentrated below 70 ℃; Herba Taraxaci, Herba Lysimachiae decoct with water three times, add 8 times of water gagings at every turn and decoct 1.5 hours, filter, and incorporate being condensed into the thick paste shape in the above-mentioned concentrated solution, dry, powder process after filtrate concentrates into; An amount of with artificial Calculus Bovis, silymarin, berberine hydrochloride and starch again, mixing is granulated, and drying sprays into Oleum menthae, adds micropowder silica gel 5g, and mixing incapsulates, and makes 1000, promptly.
Embodiment 2:
Artificial Calculus Bovis 30g silymarin 17.5g berberine hydrochloride 12.5g Rhizoma Corydalis 125g
Radix Et Rhizoma Rhei 12.5g Herba Taraxaci 150g Herba Lysimachiae 200g Oleum menthae 2g
More than eight flavors, get Rhizoma Corydalis, Radix Et Rhizoma Rhei is suitably pulverized, and makes solvent with 60% ethanol, flood after 24 hours according to (appendix IO of Chinese Pharmacopoeia version in 2005) under fluid extract and the extractum item to carry out percolation, the collection percolate is concentrated below 70 ℃; Herba Taraxaci, Herba Lysimachiae decoct with water 2 times, add 8 times of amounts of water for the first time, decoct 2 hours, add 6 times of amounts of water for the second time, decoct 1.5 hours; Filter, incorporate being condensed into the thick paste shape in the above-mentioned concentrated solution, dry, powder process after filtrate concentrates into; An amount of with artificial Calculus Bovis, silymarin, berberine hydrochloride and dextrin again, mixing is granulated, and drying sprays into Oleum menthae, adds magnesium stearate 2.5g, and mixing incapsulates, and makes 1000, promptly.
Embodiment 3:
Artificial Calculus Bovis 30g silymarin 17.5g berberine hydrochloride 12.5g Rhizoma Corydalis 125g
Radix Et Rhizoma Rhei 12.5g Herba Taraxaci 150g Herba Lysimachiae 200g Oleum menthae 2g
More than eight flavors, get Rhizoma Corydalis, Radix Et Rhizoma Rhei is suitably pulverized, and makes solvent with 60% ethanol, flood after 24 hours according to (appendix IO of Chinese Pharmacopoeia version in 2005) under fluid extract and the extractum item to carry out percolation, the collection percolate is concentrated below 70 ℃; Herba Taraxaci, Herba Lysimachiae decoct with water 4 times, add 8 times of water gagings at every turn and decoct 1 hour, filter, and incorporate being condensed into the thick paste shape in the above-mentioned concentrated solution, dry, powder process after filtrate concentrates into; An amount of with artificial Calculus Bovis, silymarin, berberine hydrochloride and lactose again, mixing is granulated, and drying sprays into Oleum menthae, adds Pulvis Talci 5g, and mixing incapsulates, and makes 1000, promptly.
Embodiment 4:
Artificial Calculus Bovis 30g silymarin 17.5g berberine hydrochloride 12.5g Rhizoma Corydalis 125g
Radix Et Rhizoma Rhei 12.5g Herba Taraxaci 150g Herba Lysimachiae 200g Oleum menthae 2g
More than eight flavors, get Rhizoma Corydalis, Radix Et Rhizoma Rhei is suitably pulverized, and makes solvent with 60% ethanol, flood after 24 hours according to (appendix IO of Chinese Pharmacopoeia version in 2005) under fluid extract and the extractum item to carry out percolation, the collection percolate is concentrated below 70 ℃.Herba Taraxaci, Herba Lysimachiae decoct with water 3 times, add 10 times of water gagings for the first time and decoct 1.5 hours, and second and third time adds 8,6 times of water gagings respectively and respectively decocted 1 hour, filters, and incorporate being condensed into the thick paste shape in the above-mentioned concentrated solution, dry, powder process after filtrate concentrates into; An amount of with artificial Calculus Bovis, silymarin, berberine hydrochloride and pregelatinized Starch again, mixing is granulated, and drying sprays into Oleum menthae, adds Pulvis Talci 2.5g, micropowder silica gel 2.5g, and mixing incapsulates, and makes 1000, promptly.
Embodiment 5:
Artificial Calculus Bovis 30g silymarin 17.5g berberine hydrochloride 12.5g Rhizoma Corydalis 125g
Radix Et Rhizoma Rhei 12.5g Herba Taraxaci 150g money grass 200g Oleum menthae 2g
More than eight flavors, get Rhizoma Corydalis, Radix Et Rhizoma Rhei is suitably pulverized, and makes solvent with 60% ethanol, flood after 24 hours according to (appendix IO of Chinese Pharmacopoeia version in 2005) under fluid extract and the extractum item to carry out percolation, the collection percolate is concentrated below 70 ℃; Herba Taraxaci, Herba Lysimachiae decoct with water three times, add 8 times of water gagings at every turn and decoct 1.5 hours, filter, and incorporate being condensed into the thick paste shape in the above-mentioned concentrated solution, dry, powder process after filtrate concentrates into; An amount of with artificial Calculus Bovis, silymarin, berberine hydrochloride and starch, dextrin, lactose (1: 1: 1) again, mixing is granulated drying; spray into Oleum menthae, add magnesium stearate 2.5g, micropowder silica gel 2.5g, Pulvis Talci 2.5g, mixing; incapsulate, make 1000, promptly.
Embodiment 6:
Artificial Calculus Bovis 30g silymarin 17.5g berberine hydrochloride 12.5g Rhizoma Corydalis 125g
Radix Et Rhizoma Rhei 12.5g Herba Taraxaci 150g Herba Lysimachiae 200g Oleum menthae 2g
More than eight flavors, get Rhizoma Corydalis, Radix Et Rhizoma Rhei is suitably pulverized, and makes solvent with 60% ethanol, flood after 24 hours according to (appendix IO of Chinese Pharmacopoeia version in 2005) under fluid extract and the extractum item to carry out percolation, the collection percolate is concentrated below 70 ℃; Herba Taraxaci, Herba Lysimachiae decoct with water three times, and amount of water is respectively 10,8,6 times of amounts, and decocting time was respectively 2.0 hours, 1.5 hours, 1.0 hours, filter, and incorporate being condensed into the thick paste shape in the above-mentioned concentrated solution, dry, powder process after filtrate concentrates into; An amount of with artificial Calculus Bovis, silymarin, berberine hydrochloride and pregelatinized Starch and dextrin again, mixing is granulated, and drying sprays into Oleum menthae, adds micropowder silica gel 5g, and mixing incapsulates, and makes 1000, promptly.
Embodiment 7:
Artificial Calculus Bovis 30g silymarin 17.5g berberine hydrochloride 12.5g Rhizoma Corydalis 125g
Radix Et Rhizoma Rhei 12.5g Herba Taraxaci 150g Herba Lysimachiae 200g Oleum menthae 2g
More than eight flavors, get Rhizoma Corydalis, Radix Et Rhizoma Rhei is suitably pulverized, and makes solvent with 3 times of amount 60% ethanol, flood after 24 hours according to (appendix IO of Chinese Pharmacopoeia version in 2005) under fluid extract and the extractum item and carries out percolation, the collection percolate is concentrated below 70 ℃; Herba Taraxaci, Herba Lysimachiae decoct with water 2 times, and amount of water is respectively 8,6 times of amounts, and decocting time was respectively 2.0 hours, 1.0 hours, filter, and incorporate being condensed into the thick paste shape in the above-mentioned concentrated solution, dry, powder process after filtrate concentrates into; With artificial Calculus Bovis, silymarin, berberine hydrochloride, mixing is granulated again, and drying sprays into Oleum menthae, and mixing incapsulates, and makes 1000, promptly.
Claims (9)
1, a kind of Chinese medicine preparation that is used for liver and gall diseases is characterized in that, it is mainly to be made up of active ingredient and/or adjuvant.
2, a kind of Chinese medicine preparation that is used for liver and gall diseases according to claim 1 is characterized in that, counts by weight percentage, and it is mainly to be made up of active ingredient 40-60% and adjuvant 60-40%.
3, according to claim 1,2 described a kind of Chinese medicine preparation that are used for liver and gall diseases; it is characterized in that; calculate by weight, described active ingredient is mainly made by following raw materials according: 2.4 parts of artificial Calculus Boviss, 1.4 parts of silymarin, 1 part of berberine hydrochloride, 10 parts of Rhizoma Corydalis, 1 part of Radix Et Rhizoma Rhei, 12 parts of Herba Taraxacis, 16 parts of Herba Lysimachiaes, 0.16 part of Oleum menthae.
4, according to claim 1,2 described a kind of Chinese medicine preparation that are used for liver and gall diseases, it is characterized in that described adjuvant includes but not limited to one or more in starch, dextrin, lactose, pregelatinized Starch, magnesium stearate, Pulvis Talci, the micropowder silica gel.
5, according to claim 2,4 described a kind of Chinese medicine preparation that are used for liver and gall diseases, it is characterized in that adjuvant is meant starch, micropowder silica gel.
6, according to claim 1,3 described a kind of preparation methoies that are used for the Chinese medicine preparation of liver and gall diseases, it is characterized in that, this tablet is preparation like this: get Rhizoma Corydalis, Radix Et Rhizoma Rhei is suitably pulverized, make solvent with 60% ethanol, flood to shine under fluid extract and the extractum item after 24 hours and carry out percolation, collect percolate, concentrating below 70 ℃; Herba Taraxaci, Herba Lysimachiae decoct with water, and filter, and incorporate being condensed into the thick paste shape in the above-mentioned concentrated solution, dry, powder process after filtrate concentrates into; With artificial Calculus Bovis, silymarin, berberine hydrochloride mixing, add or do not add right amount of auxiliary materials again, granulate, drying sprays into Oleum menthae, and prepared becomes required preparation routinely.
7, according to claim 1,6 described a kind of preparation methoies that are used for the Chinese medicine preparation of liver and gall diseases, it is characterized in that described preparation is a capsule.
8, a kind of preparation method that is used for the Chinese medicine preparation of liver and gall diseases according to claim 7, it is characterized in that, this capsule is preparation like this: get Rhizoma Corydalis, Radix Et Rhizoma Rhei is suitably pulverized, make solvent with 60% ethanol, flood to shine under fluid extract and the extractum item after 24 hours and carry out percolation, collect percolate, concentrating below 70 ℃; Herba Taraxaci, Herba Lysimachiae decoct with water 2-4 time, and amount of water 6-10 doubly measures, and decocting time 1.0-2.0 hour, filter, after concentrating, filtrate incorporates being condensed into the thick paste shape in the above-mentioned concentrated solution, dry, powder process into; With artificial Calculus Bovis, silymarin, berberine hydrochloride and right amount of auxiliary materials, mixing is granulated again, and drying sprays into Oleum menthae, and mixing incapsulates, promptly.
9, a kind of preparation method that is used for the Chinese medicine preparation of liver and gall diseases of stating according to Claim 8, it is characterized in that, this capsule is preparation like this: get Rhizoma Corydalis, Radix Et Rhizoma Rhei is suitably pulverized, make solvent with 2 times of amount 60% ethanol, flood to shine under fluid extract and the extractum item after 24 hours and carry out percolation, collect percolate, concentrating below 70 ℃; Herba Taraxaci, Herba Lysimachiae decoct with water 3 times, add 8 times of water gagings at every turn and decoct 1.5 hours, filter, and incorporate being condensed into the thick paste shape in the above-mentioned concentrated solution, dry, powder process after filtrate concentrates into; An amount of with artificial Calculus Bovis, silymarin, berberine hydrochloride and starch again, mixing is granulated, and drying sprays into Oleum menthae, adds 1.0% micropowder silica gel, and mixing incapsulates, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100669196A CN101049349A (en) | 2006-04-03 | 2006-04-03 | Chinese traditional medicine preparation in use for treating liver and gall disease, and preparation method |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2006100669196A CN101049349A (en) | 2006-04-03 | 2006-04-03 | Chinese traditional medicine preparation in use for treating liver and gall disease, and preparation method |
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| CN101049349A true CN101049349A (en) | 2007-10-10 |
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| CNA2006100669196A Pending CN101049349A (en) | 2006-04-03 | 2006-04-03 | Chinese traditional medicine preparation in use for treating liver and gall disease, and preparation method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20081403A1 (en) * | 2008-07-29 | 2010-01-30 | Velleja Res Srl | COMPOSITIONS INCLUDING BERBERINA AND / OR ITS ANALOGUES OR EXTRACTS THAT CONTAIN IT, FOR THE PREVENTION AND TREATMENT OF THE LIPID AND GLUCID FRAMEWORK ALTERATIONS |
| CN102357215A (en) * | 2011-11-16 | 2012-02-22 | 河南中医学院 | Ointment for treating right hypochondriac distention and pain caused by acute and chronic cholecystitis |
| CN104000886A (en) * | 2014-05-07 | 2014-08-27 | 马文泉 | Externally applied Chinese herbal application plaster for treating cholecystitis |
-
2006
- 2006-04-03 CN CNA2006100669196A patent/CN101049349A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20081403A1 (en) * | 2008-07-29 | 2010-01-30 | Velleja Res Srl | COMPOSITIONS INCLUDING BERBERINA AND / OR ITS ANALOGUES OR EXTRACTS THAT CONTAIN IT, FOR THE PREVENTION AND TREATMENT OF THE LIPID AND GLUCID FRAMEWORK ALTERATIONS |
| EP2149377A1 (en) * | 2008-07-29 | 2010-02-03 | Velleja Research SRL | Compositions containing berberine and/or analogues thereof or extracts containing it, for the prevention and treatment of alterations of the lipid and carbohydrate balance |
| WO2010012434A1 (en) * | 2008-07-29 | 2010-02-04 | Velleja Research S.R.L. | Compositions containing berberine and/or analogues thereof or extracts containing it, for the prevention and treatment of alterations of the lipid and carbohydrate balance |
| CN102357215A (en) * | 2011-11-16 | 2012-02-22 | 河南中医学院 | Ointment for treating right hypochondriac distention and pain caused by acute and chronic cholecystitis |
| CN102357215B (en) * | 2011-11-16 | 2013-01-02 | 河南中医学院 | Ointment for treating right hypochondriac distention and pain caused by acute and chronic cholecystitis |
| CN104000886A (en) * | 2014-05-07 | 2014-08-27 | 马文泉 | Externally applied Chinese herbal application plaster for treating cholecystitis |
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