CN100344299C - Medicine for treating woman's dysmenorrhea and preparing process thereof - Google Patents
Medicine for treating woman's dysmenorrhea and preparing process thereof Download PDFInfo
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- CN100344299C CN100344299C CNB2005100259318A CN200510025931A CN100344299C CN 100344299 C CN100344299 C CN 100344299C CN B2005100259318 A CNB2005100259318 A CN B2005100259318A CN 200510025931 A CN200510025931 A CN 200510025931A CN 100344299 C CN100344299 C CN 100344299C
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Abstract
The present invention relates to a drug used for treating female dysmenorrhea and a preparation method thereof, which belongs to the technical field of medicine. The drug used for treating female dysmenorrhea has 16 to 70% of angelica, 20 to 66% of corydalis tuber and 10 to 18% of cassia. The preparation method comprises the steps: the angelica, the corydalis tuber and a cassia powder in prescription quantities are pulverized into a fine powder to be used, and the angelica is prepared into angelica oil to be used; the cassia is prepared into cassia oil to be used, and the corydalis tuber is prepared into corydalis tuber total alkali to be used; the angelica oil, the cassia oil and the corydalis tuber total alkali are added to mixed liquid of melting dripping pill matrix which is heated on a water bath, and the mixed liquid is thoroughly agitated so as to make the mixed liquid uniform; the mixed liquid is filled into the thermal insulation pot of a pill dripping machine, is prepared by dripping under the condition of a temperature of 70 to 90 DEG C, and is dripped into a glass column containing dimethyl silicon oil at a temperature of 0 to 10 DEG C so as to be condensed, and the mixed liquid is taken out after being formed; the attached dimethyl silicon oil is absorbed by oil absorption paper so as to obtain dripping pills. The drug of the present invention has the effects of analgesia, inflammation resistance and dysmenorrhea treatment, and can be used for treating female dysmenorrhea.
Description
Technical field
What the present invention relates to is medicine of a kind of medical technical field and preparation method thereof, specifically be a kind of be the medicine and preparation method thereof of the treatment dysmenorrhes of feedstock production by Chinese medicine angelica, Cortex Cinnamomi, Rhizoma Corydalis.
Background technology
Dysmenorrhea is meant between moon paramenstrum, lower abdomen and waist spasmic pain, when serious with feel sick, vomiting, cold extremities.Dysmenorrhea is one of gynecological's common disease.According to data, the dysmenorrhea incidence rate is 33.1% among China women.Chinese medicine claims that dysmenorrhea is menstrual abdominalgia, menalgia, abdominal pain during menstruation etc., thinks that mostly dysmenorrhea is six climate exopathogens invasion and attack, incoordination of seven emotions, deficient deficiency, cause dashing appoint, the uterus QI and blood is not moving capable smooth, stagnation of QI and blood may bring about pain, or dash appoint, uterus loses in moistening fosterly, not flourish also pain is served as reasons.Modern medicine study generally believes that dysmenorrhea is mainly relevant with factors such as the interior prostaglandin of body, vasopressin, oxytocin, beta-endorphins.Relevant with heredity, environment, body oneself state in addition.
Aspect TREATMENT OF DYSMENORRHOEA, clinically there is no special effective method.The western medicine dysmenorrhea has certain curative effect, but analgesic time is short, easily recurrence after the drug withdrawal, and medicine has side effect more.As aspirin, ibuprofen, acetaminophen, nimesulide.Progesterone and medroxyprogesterone acetate etc. also can be used for TREATMENT OF DYSMENORRHOEA, but dizziness, headache arranged, feel sick, side reaction such as distending pain of the breast, life-time service can cause atrophy of endometrium, side effect such as menstrual blood volume minimizing.[Ming Haixia etc., primary dysmenorrhea pathogenesis and treatment new development. the journal .2004 of the Gansu college of traditional Chinese medicine, 21 (1): 55-57]
The traditional Chinese medical science has unique therapeutic effect to primary dysmenorrhea, and " general rule is not bitterly " is its treatment criterion.YUEYUESHU CHONGJI commonly used, WUJI BAIFENG WAN, Rhizoma Corydalis tablet for alleviating pain etc., the defective that the ubiquity taking dose is bigger.Folk prescription pharmaceutical preparation such as FUTONGNING drop pill are also arranged,, act on singlely, fail to give full play to the advantage of many target spots of Chinese medicine compound comprehensive function because it is the folk prescription medicine.[Ji Yubin. " Chinese medicine compound chemistry and pharmacology " artificial satellite's version, 2003] [Dong Keling, Chinese traditional treatment dysmenorrhea side medicine applied analysis over nearly 15 years, the Henan traditional Chinese medical science, 2003,23 (6): 57].
Summary of the invention
The objective of the invention is to overcome deficiency of the prior art, a kind of medicine that is used for the treatment of dysmenorrhes and preparation method thereof is provided.It is had no side effect, each raw material synergism, many target treatments of too many levels dysmenorrhea is better than folk prescription.
The present invention is achieved by the following technical solutions, and the present invention is used for the treatment of the medicine of dysmenorrhes, and its ingredient is made with following bulk drugs: Radix Angelicae Sinensis 16%-70%, Rhizoma Corydalis 20%-66%, Cortex Cinnamomi 10%-18% part.Aforementioned proportion is weight percentage.
Preferred Radix Angelicae Sinensis 43%, Rhizoma Corydalis 43%, Cortex Cinnamomi 14%.
The medical material of respectively distinguishing the flavor of among the present invention is crude drug, according to the theory of Chinese medical science prescription, in the side Radix Angelicae Sinensis tool enrich blood invigorate blood circulation, the function of menstruction regulating and pain relieving, loosening bowel to relieve constipation; The effect of Rhizoma Corydalis rigging promoting the circulation of QI to relieve pain, blood circulation promoting and blood stasis dispelling; Cortex Cinnamomi tool dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow function are drugs for dispelling internal cold commonly used.Each medicine synergism of distinguishing the flavor of, the function of scalable human body, blood circulation promoting and blood stasis dispelling, warming the meridian and promoting blood circulation, regulating QI to relieve pain is applicable to the caused dysmenorrhes of cold blood stasis.
The present invention is used for the treatment of the preparation method of the medicine of dysmenorrhes, and concrete steps are as follows:
1. the Radix Angelicae Sinensis pulverizing medicinal materials is crossed 40 mesh sieves, put in the supercritical CO 2 extractor, 40 ℃, 25MPa extraction 3 hours, it is standby to obtain Radix Angelicae Sinensis oil; Or pulverize the back and steeped 4 hours with water logging, it is standby that steam distillation obtained Radix Angelicae Sinensis oil in 4 hours;
2. the Cortex Cinnamomi pulverizing medicinal materials is crossed 40 mesh sieves, put in the supercritical CO 2 extractor, 40 ℃, 20MPa extraction 2 hours, it is standby to obtain Oleum Cinnamomi; Or pulverize the back and steeped 4 hours with water logging, it is standby that steam distillation obtained Oleum Cinnamomi in 4 hours;
3. corydalis tuber medicinal material was pulverized 40 mesh sieves, with concentration 70% ethanol or dilute acid soln merceration or heating and refluxing extraction, sucking filtration, filtrate is passed through cation exchange resin column or macroporous adsorptive resins, with the finite concentration alcohol flushing, eluent is volatilized solvent, it is standby to get Rhizoma Corydalis total alkaloids;
4. above-mentioned Radix Angelicae Sinensis oil, Oleum Cinnamomi, Rhizoma Corydalis total alkaloids are added in water-bath in the mixed liquor of the drop pill substrate of heating and melting, the mixed liquor of described drop pill substrate is made up of one or more of polyethylene glycol 6000, Macrogol 4000, poloxamer, Tween 80 and stearic acid.Described drop pill mesostroma and ingredient weight ratio are 90: 10-50: 50;
5. mixed solution is fully stirred, make it evenly, in the insulation jar of the drop pill machine of packing into, in following system of 70-90 ℃ condition, splash into condensation in the glass column that fills 0 ℃ of-10 ℃ of dimethicone, take out after the molding, remove adherent dimethicone with the oil-Absorbing Sheets suction, promptly get drop pill.
The present invention has following useful effect: medicine of the present invention has the effect of analgesia, antiinflammatory and treatment dysmenorrhea, is made up of pure Chinese medicine ingredients, has no side effect; By the compound Chinese medicinal preparation that three flavor Chinese herbal medicine are formed, each raw material synergism, many target treatments of too many levels dysmenorrhea is better than folk prescription; Extract and concentrate active component in the medical material, can make tablet, capsule, soft gelatin capsule, drop pill etc. according to a conventional method, reduced patient's taking dose.
The specific embodiment
The inventor adopts mice acetic acid twisting pain model, mice auricle swelling inflammatory model and dysmenorrhea model in mice that medicine of the present invention has been carried out pharmacodynamic study.Experimental result shows that the present invention has the effect of analgesia, antiinflammatory and treatment dysmenorrhea.
The invention will be further described below in conjunction with embodiment.
Embodiment one
Ingredient is made (percentage by weight) with following bulk drugs: Radix Angelicae Sinensis 70%, Rhizoma Corydalis 20%, Cortex Cinnamomi 10%.
Preparation:
1. the Radix Angelicae Sinensis pulverizing medicinal materials is crossed 40 mesh sieves, steeped 4 hours with water logging, it is standby that steam distillation obtained Radix Angelicae Sinensis oil in 4 hours;
2. the Cortex Cinnamomi pulverizing medicinal materials is crossed 40 mesh sieves, put in the supercritical CO 2 extractor, 40 ℃, 20MPa extraction 2 hours, it is standby to obtain Oleum Cinnamomi;
3. corydalis tuber medicinal material was pulverized 40 mesh sieves,, be incubated 50 ℃ of reflux, extract, 3 hours with concentration 70% ethanol, sucking filtration volatilizes solvent, with the sulfuric acid solution dissolving of pH value 3-4, filters, and filtrate is passed through cation exchange resin column.With ammonia alkalization cation exchange resin, with concentration 70% alcohol flushing, eluent is volatilized solvent, get Rhizoma Corydalis total alkaloids.
4. Radix Angelicae Sinensis oil, Oleum Cinnamomi, Rhizoma Corydalis total alkaloids are added the polyethylene glycol 6000 of heating and melting in water-bath, in the mixed solution of Macrogol 4000 and Tween 80, the part by weight of ingredient and above-mentioned mixed liquor is 30: 70.Fully stir, make it evenly, to pour insulation in the drop pill organizational security temperature jar into, in following system of 80 ± 2 ℃ conditions, condensed fluid is selected dimethicone for use, and condensate temperature remains on 0 ℃.Collect drop pill, inhale and remove the dimethicone of surface adhesion, promptly get drop pill.Use for pharmacodynamic study as reagent one.
Implementation result: obtain the drop pill that the ball type is regular, hardness is moderate.The pharmacodynamic study result shows that the drop pill that this kind method makes has obvious inhibitory action to the dysmenorrhea model mouse writhing, and mice acetic acid twisting and mice caused by dimethylbenzene xylene ear swelling are had certain inhibitory action, compares no statistically-significant difference with the blank group.Show that this medical instrument has the effect of obvious treatment dysmenorrhea and certain analgesia and antiinflammatory action.
Embodiment two
Ingredient is made (percentage by weight) with following bulk drugs: Radix Angelicae Sinensis 43%, Rhizoma Corydalis 43%, Cortex Cinnamomi 14%.
Preparation:
1. the Radix Angelicae Sinensis pulverizing medicinal materials is crossed 40 mesh sieves, steeped 4 hours with water logging, it is standby that steam distillation obtained Radix Angelicae Sinensis oil in 4 hours;
2. the Cortex Cinnamomi pulverizing medicinal materials is crossed 40 mesh sieves, steeped 4 hours with water logging, it is standby that steam distillation obtained Oleum Cinnamomi in 4 hours;
3. corydalis tuber medicinal material was pulverized 40 mesh sieves, be the sulfuric acid solution merceration 12 hours of 3-4 with the pH value, filter, with filtrate with the ammonia adjust pH to neutral, be added on the macroporous adsorptive resins that the by specification requirement handles well, with about 3 times of amount deionized water eluting, 5 times of amounts of reuse, 50% ethanol elution is collected 50% ethanol elution earlier, reclaim under reduced pressure gets Rhizoma Corydalis total alkaloids.
4. Radix Angelicae Sinensis oil, Oleum Cinnamomi, Rhizoma Corydalis total alkaloids are added the polyethylene glycol 6000 of heating and melting in water-bath, in the mixed solution of Macrogol 4000 and poloxamer, the part by weight of ingredient and above-mentioned mixed liquor is 10: 90.Fully stir, make it evenly, to pour insulation in the drop pill organizational security temperature jar into, in following system of 70 ± 2 ℃ conditions, condensed fluid is selected dimethicone for use, and condensate temperature remains on 5 ℃.Collect drop pill, inhale and remove the dimethicone of surface adhesion, promptly get drop pill.Use for pharmacodynamic study as reagent two.
Implementation result: obtain the drop pill that the ball type is regular, hardness is moderate.The pharmacodynamic study result shows that the drop pill that this kind method makes all has remarkable inhibitory action to mice acetic acid twisting, mice caused by dimethylbenzene xylene ear swelling and dysmenorrhea model mouse writhing, shows that this medical instrument has the effect of tangible analgesia, antiinflammatory and treatment dysmenorrhea.
Embodiment three
Ingredient is made (percentage by weight) with following bulk drugs: Radix Angelicae Sinensis 16%, Rhizoma Corydalis 66%, Cortex Cinnamomi 18%.
Preparation:
1. the Radix Angelicae Sinensis pulverizing medicinal materials is crossed 40 mesh sieves, put in the supercritical CO 2 extractor, 40 ℃, 25MPa extraction 3 hours, it is standby to obtain Radix Angelicae Sinensis oil;
2. the Cortex Cinnamomi pulverizing medicinal materials is crossed 40 mesh sieves, put in the supercritical CO 2 extractor, 40 ℃, 20MPa extraction 2 hours, it is standby to obtain Oleum Cinnamomi;
3. corydalis tuber medicinal material was pulverized 40 mesh sieves, and be incubated 50 ℃ of reflux, extract, 3 hours with concentration 70% ethanol, sucking filtration volatilizes solvent, with the sulfuric acid solution dissolving of pH value 3-4, filters, and filtrate is passed through cation exchange resin column.With ammonia alkalization cation exchange resin, with concentration 70% alcohol flushing, eluent is volatilized solvent, promptly get Rhizoma Corydalis total alkaloids.
4. Radix Angelicae Sinensis oil, Oleum Cinnamomi, Rhizoma Corydalis total alkaloids are added the polyethylene glycol 6000 of heating and melting in water-bath, in Macrogol 4000 and the stearic mixed liquor, the part by weight of ingredient and above-mentioned mixed liquor is 50: 50.Fully stir, make it evenly, to pour insulation in the drop pill organizational security temperature jar into, in following system of 90 ± 2 ℃ conditions, condensed fluid is selected dimethicone for use, and condensate temperature remains on 10 ℃.Collect drop pill, inhale and remove the dimethicone of surface adhesion, promptly get drop pill.Use for pharmacodynamic study as reagent three.
Implementation result: it is more regular to obtain ball shape, the drop pill that hardness is poor slightly.The pharmacodynamic study result shows that the drop pill that this kind method makes all has inhibitory action to mice acetic acid twisting, mice caused by dimethylbenzene xylene ear swelling and dysmenorrhea model mouse writhing, shows that this medical instrument has the effect of analgesia, antiinflammatory and treatment dysmenorrhea.
In conjunction with pharmacodynamic study implementation result of the present invention is described further respectively below:
The influence of 4 pairs of mice acetic acid twistings of embodiment
By observing reagent to mice acetic acid twisting inhibitory action, the analgesic effect of the medicine that evaluation different formulations and preparation method are prepared into.
Method: get 50 of mices, male and female half and half, body weight 18～22g, weigh and be divided into 5 groups at random behind the labelling, every group 10 is that reagent one (embodiment one makes medicine), reagent two (embodiment two makes medicine), reagent three (embodiment three makes medicine) are carried out gastric infusion to mice with Chinese medicine preparation prepared among the embodiment 1,2,3 respectively, and positive controls gives the bamyl (aspirin) of 200mg.kg-1.d-1, matched group gives the normal saline with volume, for three days on end.After the last administration 1 hour, lumbar injection 0.6% acetum 0.2ml/ only, observe and record injection acetum after organize respectively that mice occurs the number of times of writhing response (abdominal part shrinks indent, stretches hind leg, buttocks is raised, crawling) in 30 minutes and calculate each administration group turn round the body suppression ratio.The results are shown in Table 1.
Turn round body suppression ratio=(blank group mouse writhing number of times-experimental mice is turned round the body number of times)/blank group mouse writhing number of times * 100%.
Experimental result is carried out statistical procedures, and each administration group and blank group are relatively organized a t check, and P＜0.05 is considered to have statistically-significant difference, and P＜0.01 is considered to have statistics utmost point significant difference.Experimental result shows, compares with the blank group, and two, three pairs of mice acetic acid twistings of positive drug and reagent have extremely significantly inhibitory action (P＜0.01), and are wherein stronger with reagent two inhibitory action.
The influence of table 1 pair mice acetic acid twisting (n=10 x ± S)
| Group | The mouse writhing number of times | Turn round body suppression ratio (%) |
| Blank group positive controls reagent 1 reagent 2 reagents 3 | 55.89±16.84 27.71±7.91** 42.80±12.84 9.33±3.83** 18.43±5.60** | - 50.4 55.1 83.3 67.0 |
* and blank group be p＜0.01 relatively, and * and blank group be p＜0.05 relatively
The influence of 5 pairs of mice ear of embodiment
The excessive release of inflammatory mediator reaches a standard in dysmenorrhea and the uterine cancer cell.Medicine can be treated dysmenorrhea effectively by the release that reduces inflammatory mediator.By observing the inhibitory action of reagent, the antiinflammatory action of the medicine that evaluation different formulations and preparation method are prepared into to the mice ear degree.
Method: get 50 of Kunming mouses, ♀ ♂ half and half, body weight 18～22g, be divided into 5 groups at random, be that gastric infusion is carried out in reagent one, reagent two, three pairs of mices of reagent with Chinese medicine preparation prepared among the embodiment 1,2,3 respectively, positive controls gives the bamyl (aspirin) of 200mg.kg-1.d-1, and matched group gives the normal saline with volume, for three days on end.After the last administration 1 hour, be coated with dimethylbenzene 30ul/ in the mouse right ear two sides and only cause inflammation, left ear is not painted with normal ear.Put to death animal after 30 minutes, get the disk of left and right sides ear same area, on analytical balance, weigh and calculate the swelling rate with 6 millimeters card punch.The results are shown in Table 2.
Swelling rate=(auris dextra weight-left ear weight)/left ear weight * 100%.
Experimental result is carried out statistical procedures, and each administration group and blank group are relatively organized a t check, and P＜0.05 is considered to have statistically-significant difference, and P＜0.01 is considered to have statistics utmost point significant difference.Experimental result shows, compares with the blank group, and positive drug and reagent two, three pairs of mice auricle swellings of reagent have extremely significantly inhibitory action (P＜0.01), and are wherein stronger with reagent two inhibitory action.
The influence of table 2 pair mice ear (n=10 x ± S)
| Group | Swelling rate (%) |
| The blank group | 110.36±22.96 |
| Positive controls reagent 1 reagent 2 reagents 3 | 56.42±21.47** 94.31±24.76 62.77±17.71* 45.88±5.29** |
* and blank group be p＜0.01 relatively, and * and blank group be p＜0.05 relatively
The influence of 6 pairs of dysmenorrhea model mices of embodiment
Method: get 50 of Kunming kind female mices, body weight 20～22g by the body weight layering, is divided into 5 groups, 10 every group at random.Press 2mg.kg-1 and give mouse stomach diethylstilbestrol suspension, continuous 9 days, so that the Mouse Uterus synchronization.From the 10th day, irritate the stomach diethylstilbestrol morning every day, be that gastric infusion is carried out in reagent one, reagent two, three pairs of mices of reagent with Chinese medicine preparation prepared among the embodiment 1,2,3 afternoon respectively, positive controls gives YUEYUESHU TONGJIBAO KELI, dosage is 8g.kg-1, the blank group gives the normal saline with volume, for three days on end.After the last administration 1 hour, lumbar injection oxytocin 30u.kg-1, in back 30 minutes of the record injection mouse writhing number of times and calculate each administration group turn round the body suppression ratio.The results are shown in Table 3.
Turn round body suppression ratio=(blank group mouse writhing number of times-experimental mice is turned round the body number of times)/blank group mouse writhing number of times * 100%.
Each administration group and blank group are relatively organized a t check, and P＜0.05 is considered to have statistically-significant difference, and P＜0.01 is considered to have statistics utmost point significant difference.Experimental result shows, compares with the blank group, and a pair of dysmenorrhea model mouse writhing of positive drug and reagent has remarkable inhibitory action (P＜0.05), and two, three pairs of dysmenorrhea model mouse writhings of reagent have extremely significantly inhibitory action (P＜0.01).
The influence of table 3 pair dysmenorrhea model mice (n=10 x ± S)
| Group | The mouse writhing number of times | Turn round body suppression ratio (%) |
| Blank group positive controls reagent 1 reagent 2 reagents 3 | 25.11±16.47 8.88±3.08** 16.89±4.00* 12.00±2.98** 11.88±2.84** | - 64.6 32.7 52.2 52.7 |
* and blank group be p＜0.01 relatively, and * and blank group be p＜0.05 relatively
Claims (8)
1. a medicine that is used for the treatment of dysmenorrhes is characterized in that, its ingredient is made with following bulk drugs: Radix Angelicae Sinensis 16%-70%, and Rhizoma Corydalis 20%-66%, Cortex Cinnamomi 10%-18%, aforementioned proportion is weight percentage.
2. a kind of medicine that is used for the treatment of dysmenorrhes according to claim 1 is characterized in that its ingredient is made with following bulk drugs: Radix Angelicae Sinensis 43%, and Rhizoma Corydalis 43%, Cortex Cinnamomi 14%, aforementioned proportion is weight percentage.
3. the preparation method that is used for the treatment of the medicine of dysmenorrhes according to claim 1 is characterized in that, concrete steps are:
(1) get formula ratio Radix Angelicae Sinensis, Rhizoma Corydalis, that Cortex Cinnamomi powder is broken into fine powder is standby;
(2) it is standby Radix Angelicae Sinensis to be made Radix Angelicae Sinensis oil;
(3) it is standby Cortex Cinnamomi to be made Oleum Cinnamomi;
(4) it is standby Rhizoma Corydalis to be made Rhizoma Corydalis total alkaloids;
(5) above-mentioned Radix Angelicae Sinensis oil, Oleum Cinnamomi, Rhizoma Corydalis total alkaloids are added in water-bath in the mixed liquor of the drop pill substrate of heating and melting;
(6) mixed solution is fully stirred, make it evenly, in the insulation jar of the drop pill machine of packing into, in following system of 70-90 ℃ condition, splash into condensation in the glass column that fills 0 ℃ of-10 ℃ of dimethicone, take out after the molding, remove adherent dimethicone with the oil-Absorbing Sheets suction, promptly get drop pill.
4. the preparation method that is used for the treatment of the medicine of dysmenorrhes according to claim 3 is characterized in that, described that Radix Angelicae Sinensis is made Radix Angelicae Sinensis oil is standby, and concrete grammar is: Radix Angelicae Sinensis is crossed 40 mesh sieves, put supercritical CO
2In the extractor, 40 ℃, 25MPa extraction 3 hours, it is standby to obtain Radix Angelicae Sinensis oil; Or Radix Angelicae Sinensis is pulverized the back steeped 4 hours with water logging, it is standby that steam distillation obtained Radix Angelicae Sinensis oil in 4 hours.
5. the preparation method that is used for the treatment of the medicine of dysmenorrhes according to claim 3 is characterized in that, described that Cortex Cinnamomi is made Oleum Cinnamomi is standby, and concrete grammar is: the Cortex Cinnamomi pulverizing medicinal materials is crossed 40 mesh sieves, put supercritical CO
2In the extractor, 40 ℃, 20MPa extraction 2 hours, it is standby to obtain Oleum Cinnamomi; Or pulverize the back and steeped 4 hours with water logging, it is standby that steam distillation obtained Oleum Cinnamomi in 4 hours.
6. the preparation method that is used for the treatment of the medicine of dysmenorrhes according to claim 3, it is characterized in that, it is described that Rhizoma Corydalis is made Rhizoma Corydalis total alkaloids is standby, concrete grammar is: corydalis tuber medicinal material was pulverized 40 mesh sieves, with concentration 70% ethanol or dilute acid soln merceration or heating and refluxing extraction, sucking filtration, filtrate is passed through cation exchange resin column or macroporous adsorptive resins, with alcohol flushing, eluent is volatilized solvent, promptly get Rhizoma Corydalis total alkaloids.
7. the preparation method that is used for the treatment of the medicine of dysmenorrhes according to claim 3 is characterized in that, the mixed liquor of described drop pill substrate is made up of one or more of polyethylene glycol 6000, Macrogol 4000, poloxamer, Tween 80 and stearic acid.
8. the preparation method that is used for the treatment of the medicine of dysmenorrhes according to claim 3 is characterized in that, described drop pill mesostroma and ingredient weight ratio are 90: 10-50: 50.
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| CN101569663B (en) * | 2009-06-03 | 2011-12-07 | 江苏省中医药研究院 | Chinese medicinal composition for treating primary dysmenorrheal and preparation method thereof |
| CN103127241B (en) * | 2013-01-16 | 2014-03-26 | 成都中医药大学 | Pharmaceutical composition and preparation method for treating dysmenorrhea |
| CN108420855B (en) * | 2018-06-06 | 2020-11-17 | 四川省中医药科学院 | Pharmaceutical composition for preventing and treating dysmenorrhea |
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| Title |
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| 中药治疗原发性痛经53例 金士美，陕西中医，第17卷第6期 1996 * |
| 正交设计法优选痛经平胶囊制备工艺 丁里玉等，河北医科大学学报，第23卷第1期 2002 * |
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