CN1251748C - Lotion for treating gynecological disease and its preparation process - Google Patents
Lotion for treating gynecological disease and its preparation process Download PDFInfo
- Publication number
- CN1251748C CN1251748C CN 200410040563 CN200410040563A CN1251748C CN 1251748 C CN1251748 C CN 1251748C CN 200410040563 CN200410040563 CN 200410040563 CN 200410040563 A CN200410040563 A CN 200410040563A CN 1251748 C CN1251748 C CN 1251748C
- Authority
- CN
- China
- Prior art keywords
- lotion
- water
- amounts
- herba menthae
- fructus cnidii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000006210 lotion Substances 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract description 6
- 201000010099 disease Diseases 0.000 title abstract description 5
- 239000003814 drug Substances 0.000 claims abstract description 15
- 239000002994 raw material Substances 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 29
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 24
- 239000000706 filtrate Substances 0.000 claims description 11
- 238000000605 extraction Methods 0.000 claims description 9
- 230000006837 decompression Effects 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 238000004064 recycling Methods 0.000 claims description 6
- 238000010992 reflux Methods 0.000 claims description 6
- 238000001256 steam distillation Methods 0.000 claims description 6
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims description 5
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- GYCKQBWUSACYIF-UHFFFAOYSA-N o-hydroxybenzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1O GYCKQBWUSACYIF-UHFFFAOYSA-N 0.000 claims description 5
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 5
- 235000010234 sodium benzoate Nutrition 0.000 claims description 5
- 239000004299 sodium benzoate Substances 0.000 claims description 5
- 230000000694 effects Effects 0.000 abstract description 24
- 206010046914 Vaginal infection Diseases 0.000 abstract description 16
- 201000008100 Vaginitis Diseases 0.000 abstract description 15
- 206010008323 cervicitis Diseases 0.000 abstract description 15
- 208000006374 Uterine Cervicitis Diseases 0.000 abstract description 13
- 208000003251 Pruritus Diseases 0.000 abstract description 10
- 229940079593 drug Drugs 0.000 abstract description 4
- 230000006870 function Effects 0.000 abstract description 3
- 235000013399 edible fruits Nutrition 0.000 abstract description 2
- 239000002085 irritant Substances 0.000 abstract description 2
- 231100000021 irritant Toxicity 0.000 abstract description 2
- 230000007803 itching Effects 0.000 abstract description 2
- MFYSUUPKMDJYPF-UHFFFAOYSA-N 2-[(4-methyl-2-nitrophenyl)diazenyl]-3-oxo-n-phenylbutanamide Chemical compound C=1C=CC=CC=1NC(=O)C(C(=O)C)N=NC1=CC=C(C)C=C1[N+]([O-])=O MFYSUUPKMDJYPF-UHFFFAOYSA-N 0.000 abstract 1
- 241000212948 Cnidium Species 0.000 abstract 1
- 235000006679 Mentha X verticillata Nutrition 0.000 abstract 1
- 235000002899 Mentha suaveolens Nutrition 0.000 abstract 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 abstract 1
- 241000219784 Sophora Species 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 11
- 239000007788 liquid Substances 0.000 description 9
- 210000001215 vagina Anatomy 0.000 description 7
- 125000001246 bromo group Chemical group Br* 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- XVPBINOPNYFXID-JARXUMMXSA-N 85u4c366qs Chemical compound C([C@@H]1CCC[N@+]2(CCC[C@H]3[C@@H]21)[O-])N1[C@@H]3CCCC1=O XVPBINOPNYFXID-JARXUMMXSA-N 0.000 description 4
- 206010047799 Vulvovaginitis trichomonal Diseases 0.000 description 4
- 230000009471 action Effects 0.000 description 4
- 230000003110 anti-inflammatory effect Effects 0.000 description 4
- 238000011010 flushing procedure Methods 0.000 description 4
- 238000002386 leaching Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 229930015582 oxymatrine Natural products 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- 210000003905 vulva Anatomy 0.000 description 4
- ZSBXGIUJOOQZMP-UHFFFAOYSA-N Isomatrine Natural products C1CCC2CN3C(=O)CCCC3C3C2N1CCC3 ZSBXGIUJOOQZMP-UHFFFAOYSA-N 0.000 description 3
- ZSBXGIUJOOQZMP-JLNYLFASSA-N Matrine Chemical compound C1CC[C@H]2CN3C(=O)CCC[C@@H]3[C@@H]3[C@H]2N1CCC3 ZSBXGIUJOOQZMP-JLNYLFASSA-N 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000001139 anti-pruritic effect Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000003748 differential diagnosis Methods 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 238000000386 microscopy Methods 0.000 description 3
- 210000004877 mucosa Anatomy 0.000 description 3
- 206010046901 vaginal discharge Diseases 0.000 description 3
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical group CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 208000004926 Bacterial Vaginosis Diseases 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
- 206010020565 Hyperaemia Diseases 0.000 description 2
- HPUXDMUGCAWDFW-UHFFFAOYSA-N Osthole Natural products COc1ccc2CCC(=O)Oc2c1C=CC(=O)C HPUXDMUGCAWDFW-UHFFFAOYSA-N 0.000 description 2
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 description 2
- 206010048245 Yellow skin Diseases 0.000 description 2
- 208000031971 Yin Deficiency Diseases 0.000 description 2
- 229930013930 alkaloid Natural products 0.000 description 2
- 230000001572 anti-trichomonad Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 210000003756 cervix mucus Anatomy 0.000 description 2
- 201000003988 chronic cervicitis Diseases 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 229930014456 matrine Natural products 0.000 description 2
- 229940041616 menthol Drugs 0.000 description 2
- MBRLOUHOWLUMFF-UHFFFAOYSA-N osthole Chemical compound C1=CC(=O)OC2=C(CC=C(C)C)C(OC)=CC=C21 MBRLOUHOWLUMFF-UHFFFAOYSA-N 0.000 description 2
- 208000037920 primary disease Diseases 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 235000021251 pulses Nutrition 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- ZSBXGIUJOOQZMP-BHPKHCPMSA-N sophoridine Chemical compound C1CC[C@@H]2CN3C(=O)CCC[C@@H]3[C@@H]3[C@H]2N1CCC3 ZSBXGIUJOOQZMP-BHPKHCPMSA-N 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 206010059313 Anogenital warts Diseases 0.000 description 1
- 206010003445 Ascites Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 241000522215 Dipteryx odorata Species 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000016908 Female Genital disease Diseases 0.000 description 1
- 206010016825 Flushing Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000588653 Neisseria Species 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 240000007509 Phytolacca dioica Species 0.000 description 1
- 206010067268 Post procedural infection Diseases 0.000 description 1
- 208000008350 Pruritus Vulvae Diseases 0.000 description 1
- 208000028017 Psychotic disease Diseases 0.000 description 1
- 241000517304 Pthirus pubis Species 0.000 description 1
- 206010061926 Purulence Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 208000007074 Trichomonas Vaginitis Diseases 0.000 description 1
- 208000025206 Trichomonas vaginitis urogenital infection Diseases 0.000 description 1
- 206010056530 Vulvovaginal pruritus Diseases 0.000 description 1
- 208000005946 Xerostomia Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 235000013527 bean curd Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000003679 cervix uteri Anatomy 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 229940000406 drug candidate Drugs 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- DNJIEGIFACGWOD-UHFFFAOYSA-N ethanethiol Chemical compound CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000003958 fumigation Methods 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 201000005630 leukorrhea Diseases 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 210000002640 perineum Anatomy 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000004706 scrotum Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 239000002893 slag Substances 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a lotion for treating gynecological diseases and a preparation method thereof. The lotion of the present invention comprises the following raw materials: 10 to 30 parts by weight of common cnidium fruit, 90 to 110 parts by weight of lightyellow sophora root, 40 to 60 parts by weight of rhizoma and 20 to 30 parts by weight of mint. Because of the prescription and the preparation method of the present invention, functions of effective parts of the medicines and mutual synergistic effect among the medicines can be fully exerted, and the lotion has optimum efficiency of treating diseases. The lotion of the present invention has good treating and itching relieving effect on various kinds of vaginitis and cervicitis of women, and no irritant side effect exists.
Description
Technical field
The present invention relates to treat the medicament of gynaecopathia, specifically is the lotion that raw material is made with the Chinese herbal medicine.The invention still further relates to its preparation method.
Background technology
Gynaecopathia such as vaginitis and cervicitis etc. are women's commonly encountered diseases, can cause leucorrhea abnormal, swelling of external genitals, flushing, fester, increase patient's misery, influence WomanHealth.Though traditional external sterilizing cleaning agent 1/5000 concentration bromo geramine liquid has curative effect preferably to colpitis mycotica and all the other vaginitiss and cervicitis, bromo geramine liquid has two flushings skin irritant performance to take place the back several times, and its antipruritic effect is also undesirable.
Summary of the invention
It is good that order of the present invention provides fruit a kind of better curative effect to various vaginitiss of women and cervicitis, antipruritic, and the lotion of the treatment gynaecopathia of nonirritant side effect and preparation method thereof.
Lotion of the present invention is according to traditional experience of tcm of motherland, and carry out the preparation of scientific formula and science, obtain lotion of the present invention, be used for the treatment of pruritus vulvae, women's damp-heat vaginal discharge, mycotic and trichomonal vaginitis, medicine directly contact lesions position, give full play to antibiotic, anti-trichomonal, antiinflammatory, the itching-relieving action of local application, reach improve curative effect, reduce side effect, purpose easy to use.
The lotion of treatment gynaecopathia of the present invention is the medicament of being made by following weight proportion raw material:
Fructus Cnidii 10～30, Radix Sophorae Flavescentis 90～110, Rhizoma Smilacis Glabrae 40～60, Herba Menthae 20～30.
Its preparation method is to produce according to the following steps:
1) get Fructus Cnidii and soaked 10～15 minutes with 8～9 times of amounts of 60% ethanol, the heating and refluxing extraction secondary, each 1～1.5 hour, merging filtrate filtered, and decompression recycling ethanol is standby;
2) Herba Menthae is used steam distillation, and medicinal residues and Radix Sophorae Flavescentis, Rhizoma Smilacis Glabrae decoct with water three times, adds 8～12 times of amounts of water for the first time, decocts embodiment 1:
Choose following raw material (unit of weight: kilogram):
Fructus Cnidii 20, Radix Sophorae Flavescentis 100, Rhizoma Smilacis Glabrae 50, Herba Menthae 25.
Preparation method:
1) Fructus Cnidii was soaked 10 minutes with 8 times of amounts of 60%7 alcohol, the heating and refluxing extraction secondary, each 1 hour, merging filtrate filtered, and decompression recycling ethanol is standby;
2) Herba Menthae is used steam distillation, and medicinal residues and Radix Sophorae Flavescentis, Rhizoma Smilacis Glabrae decoct with water three times, adds 10 times of amounts of water for the first time, decocted 2～2.5 hours, second and third time adds 6～10 times of amounts of water respectively, decocts 1～2 hour, collecting decoction filters, and it is 1.10～1.15 that filtrate is concentrated into relative density, add the Fructus Cnidii concentrated solution, put coldly, add Herba Menthae distillate, sodium benzoate 4.5～6 (weight portion), ethyl hydroxybenzoate 0.4～0.6 (weight portion), add water and be adjusted to total amount, mixing filters, promptly.
The physicochemical property of the contained effective ingredient of Chinese crude drug (position) of respectively distinguishing the flavor of in the lotion of the present invention and with function to cure mainly relevant pharmacological action as follows:
Radix Sophorae Flavescentis mainly contains alkaloids compositions such as matrine, oxymatrine, sophoridine, and oxymatrine accounts for more than 90% in the Radix Sophorae Flavescentis total alkaloids.Matrine alkaloid polarity is big, and is soluble in water, has antibiotic, anti-trichomonal, antiinflammatory action, is used for the treatment of vaginitis, cervicitis, pelvic inflammatory disease with matrine and Radix Sophorae Flavescentis decocting liquid vagina administration clinically, safe and effective.Rhizoma Smilacis Glabrae contains water soluble ingredients such as glycoside, organic acid, clinical with its decocting liquid part embrocate, fumigation and wash method is used for the treatment of vaginitis, the condyloma acuminatum effect is remarkable.
Herba Menthae contains volatile oil (main component is a menthol) and phenols component, and its decocting liquid has vitro antibacterial activity; The compound topical application that contains menthol has antiinflammatory, analgesic effect.
Fructus Cnidii contains tonkabean constituents such as volatile oil and Fructus Cnidii, osthole, bergapton, and its decocting liquid treatment eczema scrotum of clinical external, pudendal pruritus, pubic louse, vaginitis, cervicitis, pelvic inflammatory disease etc. are evident in efficacy.Osthole is water insoluble, can be dissolved in alcohol, chloroform, acetone and alkaline solution, has stronger antibacterial action, and trichomonas vaginitis is also had certain inhibitory action, the clinical outer treatment that is used for trichomonal vaginitis and skin fungus, and itching-relieving action is arranged.
Lotion preparation of the present invention is scientifically measured the time of Fructus Cnidii extraction time, number of times and Herba Menthae distillation extraction to obtain best yield.The screening of Radix Sophorae Flavescentis, Rhizoma Smilacis Glabrae decocting process conditions is to carry out orthogonal test by certain factor, level design, with water solublity total solid leaching rate and oxymatrine leaching rate serves as to investigate index, amount of water, extraction time and number of times have appreciable impact to the total solid leaching rate, the oxymatrine leaching rate is not made significant difference, determine the preparation method of lotion science of the present invention thus.
Prescription of the present invention and preparation method make the above-mentioned medicine of respectively distinguishing the flavor of can give full play to the mutual synergism between its effective site effect and a few flavor medicine, make this medicament have the optimum efficiency of treatment disease.
Below be that lotion of the present invention carries out clinical trial controlled observation result in gynecological of No.1 Hospital Attached to Kunming Medical College:
One, experiment purpose
Observe and estimate lotion of the present invention vaginitis, the therapeutic effect of cervicitis, and investigate its toxic and side effects.
Two, physical data
Observe case 150 examples, test group 100 examples wherein, matched group 50 examples, maximum 52 years old age in the test group, minimal ages 21 years old, 35.9 years old mean age.Maximum 51 years old age in the matched group, minimal ages 22 years old, 34.6 years old mean age.See Table 1, table 2 and table 3:
Table 1 age structure table
| Group | Age (year) | |||
| 20-29 | 30-39 | 4049 | 50-59 | |
| The test group matched group adds up to | 29 11 40 | 36 25 61 | 28 11 39 | 7 3 10 |
The no significant difference in P＞0.05
Table 2 test group and matched group are sick plants
| Group | Trichomonal vaginitis | Mould road vaginitis | Nonspecific vaginitis | Cervicitis | ||
| I° | II° | III° | ||||
| The test group matched group | 9 3 | 36 23 | 29 12 | 12 8 | 8 2 | 6 2 |
Table 3 differential diagnosis in tcm table
| Group | Ascites of liver meridian damp-heat type | Liver-kidney yin deficiency |
| The test group matched group | 76 39 | 24 11 |
Three, case choice criteria
Vaginitis in the selection female genital disease and chronic cervicitis are for observing.
1, diagnostic criteria
(1) Western medicine diagnose standard
Vaginitis patient leucorrhoea grow in quantity or pruritus discomfort, leucorrhea are purulence or bean curd slag specimen, stench, vaginal mucosa hyperemia, and conventional leucorrhea smear is looked into cleannes.Infusorian, mould road, gonococcus, look into vagina cleanness degree.
Cervicitis patient's leucorrhoea grow in quantity, cervical erosion hyperemia, conventional temporary dwelling palace neck cell learn check with except malignant change.
(2) differential diagnosis in tcm
Dampness-heat of the liver disease:
The pudendum flushing, swelling, the pain of very then itching, uneasy in either sitting or lying, profuse leukorrhea, yellow skin such as pus, or be foam water from washing rice sample, red tongue, yellow and greasy fur wiry and frequent pulse.
Hepatic and renal YIN deficiency disease:
Dry and astringent, the scorching hot pruritus of pudendum, or the few yellow skin of leukorrhagia amount, very then as blood sample, dysphoria with feverish sensation in the chest palms and soles is had a dizzy spell, the time warm sweating, xerostomia is the desire drink not, tinnitus and soreness of loins, red tongue is tongue less, thready and rapid pulse without strength.
2, test case standard
(1) includes the case standard in
Meet trichomonal vaginitis, mould road vaginitis nonspecific vaginitis and chronic cervicitis diagnosis and differential diagnosis in tcm person can include the test case in.
(2) get rid of the case standard
Age is at under-18s or more than 60 years old; Gestation or women breast-feeding their children; To the primary disease allergy sufferers; Be associated with serious primary disease such as cardiovascular, liver, kidney and hemopoietic system, the psychotic; Not treatment in accordance with regulations can't be judged not umbra sound curative effect person of curative effect or data.
Four, observation index
1, health giving quality is observed
Clinical manifestation: symptom, sign change;
Gynecologial examination: vagina, cervical secretions inspection.
2, side effect is observed
In the process of the test as toxicity occurs, drug withdrawal immediately, and record faithfully.
Five, clinical observation scheme
1, test method
Single at random blind method is adopted in this test, is in hospital and the outpatient washes treatment by outpatient service gyniatrics chamber special messenger, and strict control variable factor is observed not adding with under other medicine principle.
2, medication, consumption and curative effect
Investigational agent: lotion of the present invention, add warm water and be made into 20% concentration once a day for pudendum, vaginadouche, treating 7 days continuously is a course of treatment.
Contrast medicine: 5% bromo geramine solution, producer: the emerging pharmaceutical factory of traditional Chinese medicine in Kunming, lot number: 991201
1/5000 attempts bromo geramine liquid rinsing vulva, vagina once a day, 7 days one courses of treatment.
Six, curative effect determinate standard
1, recovery from illness: symptom, sign disappear, and check and recover I ° of normal leucorrhea cleannes.
2, produce effects: symptom, sign obviously alleviates, leucorrhea microscopy feminine gender, vagina cleanness degree I ° or II °.
3, effective: symptom, sign alleviates, and leucorrhea microscopy positive or negative, vagina cleanness degree are II °, III °.
4, invalid: symptom, sign no change, the leucorrhea microscopy positive.
Following table 4, table 5 are observation of curative effect results
Table 4 vaginitis curative effect table
| Group | The example number | Infusorian property | Mould road | Non-specific | ||||||||||||
| Pool more | The amount number | Effectively | Invalid | Effective percentage % | Cure | The amount number | Effectively | Invalid | Effective percentage % | Cure | The amount number | Effectively | Invalid | Effective percentage % | ||
| The experimental group matched group | 74 38 | 9 1 | 2 2 | 1 0 | 0 0 | 100 100 | 23 11 | 9 7 | 3 4 | 1 1 | 99 97 | 21 6 | 3 2 | 2 2 | 0 0 | 100 100 |
The no significant difference in P＞0.05.
Table 5 cervicitis curative effect table
| Group | The example number | I° | II° | III° | ||||||||||||
| Recovery from illness | Produce effects | Effectively | Invalid | Effective percentage % | Recovery from illness | Produce effects | Effectively | Invalid | Effective percentage % | Recovery from illness | Produce effects | Effectively | Invalid | Effective percentage % | ||
| The experimental group matched group adds up to | 26 12 38 | 6 4 10 | 3 2 5 | 3 2 5 | 0 0 0 | 100 100 | 1 0 1 | 4 2 6 | 3 0 3 | 0 0 0 | 100 100 | 0 0 0 | 3 1 4 | 3 1 4 | 0 0 0 | 100 100 |
Seven, untoward reaction is observed
Lotion rinsing vulva of the present invention, vaginal treatment 100 examples have no adverse reaction and anaphylaxis.
Have 2 people to feel skin of vulva twinge, pruritus after the 1/5000 bromo geramine rinsing vulva, vaginadouche 4 times, after take a turn for the better after treatment.
Eight, conclusion
According to this clinical observation experiment result lotion of the present invention perineum and vagina, cervix uteri, skin, mucosa there are cleaning, sterilization and antiinflammatory, itching-relieving action.Be used for vaginitis 74 examples in this group case, effective percentage 100%, wherein cure rate reaches 75.7%.Treatment cervicitis 26 examples, effective percentage reaches 100%, and wherein cure rate reaches 26.9%, and better to slight cervicitis therapeutic effect, cure rate reaches 50%.Cervicitis treatment back leucorrhea obviously reduces, and laser and the cold therapy healing of going again after the flushing is fast, promotes epithelial repair, and prevention naturopathy postoperative infection takes place.
Lotion of the present invention has heat-clearing and toxic substances removing, damp eliminating, the function of the wind that looses, be used for damp-heat vaginal discharge, its effects of vaginitis treatment such as the red and swollen pruritus of pudendum significantly, be used for pudendum, vaginadouche, reach the effect of antibacterial parasite killing easing pain and diminishing inflammation, and fine antipruritic effect is arranged, do not find untoward reaction in the therapeutic process, the medicinal liquid of dilution 20% is to skin, mucosa nonirritant, and is safe in utilization.
The specific embodiment
Embodiment 1:
Choose following raw material (unit of weight: kilogram):
Fructus Cnidii 20, Radix Sophorae Flavescentis 100, Rhizoma Smilacis Glabrae 50, Herba Menthae 25.
Preparation method:
1) Fructus Cnidii was soaked 10 minutes with 8 times of amounts of 60% ethanol, the heating and refluxing extraction secondary, each 1 hour, merging filtrate filtered, and decompression recycling ethanol is standby;
2) Herba Menthae is used steam distillation, and medicinal residues and Radix Sophorae Flavescentis, Rhizoma Smilacis Glabrae decoct with water three times, adds 10 times of amounts of water for the first time, decocted 2 hours, second and third time adds 8 times of amounts of water respectively, decocts 1.5 hours, collecting decoction filters, and it is 1.10～1.15 (98 ℃) that filtrate is concentrated into relative density, add the Fructus Cnidii concentrated solution, put coldly, add Herba Menthae distillate, 5 kilograms of sodium benzoate, 0.5 kilogram of ethyl hydroxybenzoate, add water and be adjusted to 1000 liters of total amounts, mixing filters, promptly.
This product be yellowish-brown to dark-brown liquid, feeble QI perfume (or spice).
Embodiment 2:
Choose following raw material (unit of weight: kilogram):
Fructus Cnidii 10, Radix Sophorae Flavescentis 90, Rhizoma Smilacis Glabrae 40, Herba Menthae 20.
Preparation method:
1) Fructus Cnidii was soaked 10 minutes with 8 times of amounts of 60% ethanol, the heating and refluxing extraction secondary, each 1 hour, merging filtrate filtered, and decompression recycling ethanol is standby;
2) Herba Menthae is used steam distillation, and medicinal residues and Radix Sophorae Flavescentis, Rhizoma Smilacis Glabrae decoct with water three times, adds 10 times of amounts of water for the first time, decocted 2 hours, second and third time adds 8 times of amounts of water respectively, decocts 1.5 hours, collecting decoction filters, and it is 1.10～1.15 (98 ℃) that filtrate is concentrated into relative density, add the Fructus Cnidii concentrated solution, put coldly, add Herba Menthae distillate, 4.5 kilograms of sodium benzoate, 0.4 kilogram of ethyl hydroxybenzoate, add water and be adjusted to 1000 liters of total amounts, mixing filters, promptly.
Embodiment 3:
Choose following raw material (unit of weight: kilogram):
Fructus Cnidii 30, Radix Sophorae Flavescentis 110, Rhizoma Smilacis Glabrae 60, Herba Menthae 30.
Preparation method:
1) Fructus Cnidii was soaked 15 minutes with 9 times of amounts of 60% ethanol, the heating and refluxing extraction secondary, each 1.5 hours, merging filtrate filtered, and decompression recycling ethanol is standby;
2) Herba Menthae is used steam distillation, and medicinal residues and Radix Sophorae Flavescentis, Rhizoma Smilacis Glabrae decoct with water three times, adds 12 times of amounts of water for the first time, decocted 2.5 hours, second and third time adds 10 times of amounts of water respectively, decocts 2 hours, collecting decoction filters, and it is 1.10～1.15 (98 ℃) that filtrate is concentrated into relative density, add the Fructus Cnidii concentrated solution, put coldly, add Herba Menthae distillate, 6 kilograms of sodium benzoate, 0.6 kilogram of ethyl hydroxybenzoate, add water and be adjusted to 1000 liters of total amounts, mixing filters, promptly.
Claims (2)
1. lotion for the treatment of gynaecopathia is characterized in that it is the medicament of being made by following weight proportion raw material:
Fructus Cnidii 10～30, Radix Sophorae Flavescentis 90～110, Rhizoma Smilacis Glabrae 40～60, Herba Menthae 20～30.
2. press the preparation method of the lotion of the described treatment gynaecopathia of claim 1, it is characterized in that producing according to the following steps:
1) get Fructus Cnidii and soaked 10～15 minutes with 8～9 times of amounts of 60% ethanol, the heating and refluxing extraction secondary, each 1～1.5 hour, merging filtrate filtered, and decompression recycling ethanol is standby;
2) Herba Menthae is used steam distillation, and medicinal residues and Radix Sophorae Flavescentis, Rhizoma Smilacis Glabrae decoct with water three times, adds 8～12 times of amounts of water for the first time, decocted 2～2.5 hours, second and third time adds 6～10 times of amounts of water respectively, decocts 1～2 hour, collecting decoction filters, and it is 1.10～1.15 that filtrate is concentrated into relative density, add the Fructus Cnidii concentrated solution, put coldly, add Herba Menthae distillate, sodium benzoate 4.5～6 (weight portion), ethyl hydroxybenzoate 0.4～0.6 (weight portion), add water and be adjusted to total amount, mixing filters, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410040563 CN1251748C (en) | 2004-08-26 | 2004-08-26 | Lotion for treating gynecological disease and its preparation process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410040563 CN1251748C (en) | 2004-08-26 | 2004-08-26 | Lotion for treating gynecological disease and its preparation process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1628771A CN1628771A (en) | 2005-06-22 |
| CN1251748C true CN1251748C (en) | 2006-04-19 |
Family
ID=34845835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410040563 Expired - Fee Related CN1251748C (en) | 2004-08-26 | 2004-08-26 | Lotion for treating gynecological disease and its preparation process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1251748C (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105125870A (en) * | 2015-09-28 | 2015-12-09 | 高辉花 | Traditional Chinese medicine for treating chronic cervicitis |
| CN106908542A (en) * | 2017-03-16 | 2017-06-30 | 云南优克制药公司 | The quality determining method of antipyretic and itching-stopping lotion |
| WO2020010919A1 (en) * | 2018-07-12 | 2020-01-16 | 江苏正阳药业有限公司 | Traditional chinese medicine composition, traditional chinese medicine compound preparation and preparation method and use thereof |
| CN108671178A (en) * | 2018-07-26 | 2018-10-19 | 贵州东仪医疗器械有限公司 | A kind of private parts is antibacterial, antipruritic, anti-inflammatory preparation and its preparation method and application |
| CN111012859A (en) * | 2019-12-30 | 2020-04-17 | 重庆宫妙生物科技有限公司 | Bacteriostatic external pill of composite biological preparation |
| CN111888408A (en) * | 2020-08-11 | 2020-11-06 | 西安浩然药业有限责任公司 | Preparation method of antibacterial gel |
| CN112316012A (en) * | 2020-11-19 | 2021-02-05 | 陕西康乐实业有限公司 | Moisturizing antibacterial gel and preparation method thereof |
| CN112999128B (en) * | 2021-03-19 | 2022-07-08 | 陕西倍康健生物科技有限公司 | Natural galenical composition with mosquito repelling and itching relieving functions |
-
2004
- 2004-08-26 CN CN 200410040563 patent/CN1251748C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1628771A (en) | 2005-06-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101195008B (en) | Cattail pollen skin cleaning agent for treating gynecology disease and technique of preparing the same thereof | |
| CN1031174C (en) | Bactericidal fabric, its producing method and use thereof | |
| CN103800772A (en) | Gynecological external lotion for preventing and treating vagina inflammatory diseases and preparation method thereof | |
| CN100586447C (en) | Chinese medicine wash liquid used for treating leucorrhea, pruritus vulvae etc. | |
| CN1251748C (en) | Lotion for treating gynecological disease and its preparation process | |
| CN1927322A (en) | Liposoluble traditional medicine bougie for treating acute and chronic prostatitis, and manufacturing technique thereof | |
| CN103041247B (en) | Traditional Chinese medicine suppository for curing colpitis and preparation method thereof | |
| CN1565550A (en) | Chinese traditional medicine for treating gynecopathy and dermatoses and preparation thereof | |
| CN1709302A (en) | Chinese medicine formulation for treating chronic pelvic inflammation and its preparing method | |
| CN100344299C (en) | Medicine for treating woman's dysmenorrhea and preparing process thereof | |
| CN1689591A (en) | Chinese medicine for treating gynopathy and its preparing process | |
| CN1197614C (en) | Chinese medicine cap sule for treating prostatic disorders | |
| CN1239185C (en) | Externally applied medical lotion for treating gynecopathy and its preparing process | |
| CN101053612A (en) | External applied traditional Chinese medicine vagina cleaning agent for curing gynecopathy and vagina cleaning ointment thereof | |
| CN1240412C (en) | Chinese medicine compound preparation for treating piles and preparing process thereof | |
| CN1876088A (en) | A medicine for treating chronic prostatitis and preparation method thereof | |
| CN1195540C (en) | Medicines for treating chronic prostatitis and preparation thereof | |
| CN1330332C (en) | Medicine for curing vaginits and dermatosis and its preparation method | |
| CN1772239A (en) | Chinese medicine prepn for treating vaginitis and cervicitis | |
| CN105232762A (en) | Prostatitis and prostatic hyperplasia treatment traditional Chinese medicine composition and preparation method thereof | |
| CN1259961C (en) | Medicination for curing kidney disease and preparation method | |
| CN1686272A (en) | Medicine for treating chronic prostatitis and its preparation method | |
| CN116832125B (en) | Traditional Chinese medicine composition, preparation method and application thereof | |
| CN1262292C (en) | Medicie composition, preparing method and use for preparing gynaecopathia medicine | |
| CN102085267A (en) | Traditional Chinese medicinal washing liquid for treating female vulvitis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20060419 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |