CN100586447C - Chinese medicine wash liquid used for treating leucorrhea, pruritus vulvae etc. - Google Patents
Chinese medicine wash liquid used for treating leucorrhea, pruritus vulvae etc. Download PDFInfo
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- CN100586447C CN100586447C CN200710029682A CN200710029682A CN100586447C CN 100586447 C CN100586447 C CN 100586447C CN 200710029682 A CN200710029682 A CN 200710029682A CN 200710029682 A CN200710029682 A CN 200710029682A CN 100586447 C CN100586447 C CN 100586447C
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Abstract
The invention provides a Chinese medicinal lotion for treating leucorrhoea disease and its preparing process, wherein the lotion is prepared from Chinaberry bark 270-350 parts, eriocarpous glochidionleaf 270-350 parts, cnidium fruit 170-220 parts, basket fern 270-350 parts, fibraurea stem 80-110 parts, broom cypress fruit 170-220 parts, baeckea 270-350 parts, flavescent sophora root 170-220 parts, borneol 0. 180. 22 part. The preparing process consists of extracting volatile oil from baeckea and cnidium fruit, mixing the dross with basket fern, fibraurea stem, flavescent sophora root, broom cypress fruit, eriocarpous glochidion leaf and chinaberry bark, watering and boiling twice, merging the grilling liquid and concentrating, depositing with alcohol and obtaining concentration liquid, charging sodium benzoate, stirring, dissolving borneol and volatile oil with ethanol and Tween-80, charging concentrated liquid, watering, homogenizing, stewing till the second day, filtering and loading.
Description
Technical field
The present invention relates to a kind of medicine for external use, refer in particular to a kind of Chinese medicine washing liquid that is used for the treatment of diseases such as leukorrhagia, pudendal pruritus, the invention still further relates to the preparation method of above-mentioned washing liquid.
Background technology
Along with the change of life style, the ill characteristics of gynaecopathia are also in continuous variation.According to hygiene department's statistics, China women suffers from the sickness rate fast rise of gynaecopathias such as leukorrheal diseases, pelvic inflammatory disease, adnexitis, and ill crowd also is extended to the young woman gradually.The name of " leukorrhagia ", head sees " interior warp ", says as " element is asked the bone empty talk ": " conception vessel is for sick ... woman's leukorrhagia abdominal mass is poly-"."Fu Qingzhu works on obstetric" is classified first volume as, and thinks " leukorrhagia all is a damp syndrome ".Leukorrheal diseases are trouble with the damp, so its disease is touching, outbreak repeatedly is difficult for speed more, and diseases such as Chang Bingfa menoxenia, amenorrhea, infertile, lump in the abdomen, are the commonly encountered diseases that is only second to menopathy in the gynecological field.The Therapeutic Principle is based on spleen invigorating, yang invigorating, dehumidifying.Women's pudendum and pruritus of vagina are felt restless, and are called " pudendal pruritus ".The cause of disease is many disturbs pudendum etc. by damp invasion of lower energizer, insufficiency of the spleen stagnation of liver-QI, worm and causes.Excess syndrome needs clearing away heat-damp and promoting diuresis, detoxifcation parasite killing, and deficiency syndrome need invigorating the liver and kidney, qi and blood invigorating, all can cooperate topical therapeutic.Chinese medicine is because its good clinical practice effect and environment-friendly and green has powerful advantage aspect the treatment gynaecopathia, and gynecological's auxiliary treatment medicine that exploitation is relevant has vast market prospect.
Summary of the invention
The technical problem that will solve of the present invention provides a kind of Chinese medicine washing liquid that is used for the treatment of diseases such as leukorrhagia, pudendal pruritus of easy to use, safe, determined curative effect.
Another technical problem that the present invention will solve provides the preparation method of above-mentioned washing liquid.
Last technical scheme of the present invention is such: a kind of Chinese medicine washing liquid that is used for the treatment of diseases such as leukorrhagia, pudendal pruritus, be the water preparation of making by the raw material of Chinese medicine of following weight parts, 270～350 parts of Cortex Meliaees, 270～350 parts of Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi)s, 170～220 parts of Fructus Cnidiis, 270～350 parts of Rhizoma Osmundae, 80～110 parts of Caulis Fibraureaes, 170～220 parts of the Fructus Kochiae, 270～350 parts of Folium Baeckeaes, 170～220 parts of Radix Sophorae Flavescentiss, 0.18～0.22 part of Borneolum Syntheticum.
The weight portion of raw material of Chinese medicine is preferably 285～335 parts of Cortex Meliaees, 285～335 parts of Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi)s, 180～210 parts of Fructus Cnidiis, 285～335 parts of Rhizoma Osmundae, 85～105 parts of Caulis Fibraureaes, 180～210 parts of the Fructus Kochiae, 285～335 parts of Folium Baeckeaes, 180～210 parts of Radix Sophorae Flavescentiss, 0.19～0.21 part of Borneolum Syntheticum described in above-mentioned a kind of Chinese medicine washing liquid that is used for the treatment of diseases such as leukorrhagia, pudendal pruritus.
Back of the present invention one technical scheme is such: a kind of preparation method that is used for the treatment of the Chinese medicine washing liquid of diseases such as leukorrhagia, pudendal pruritus, it is characterized in that comprising the steps: that (1) gets Folium Baeckeae, Fructus Cnidii extracts volatile oil, and the aqueous solution after distillation device is in addition collected; (2) Folium Baeckeae, Fructus Cnidii medicinal residues and all the other Rhizoma Osmundae, Caulis Fibraureae, Radix Sophorae Flavescentis, the Fructus Kochiae, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi), the Cortex Meliae Six-element behind the extraction volatile oil, decoct with water secondary, aqueous solution after collecting decoction and the distillation filters, and filtrate is concentrated into the concentrated solution A that relative density is about 1.20/65 ℃; (3) concentrated solution A adds ethanol and makes and contain alcohol amount and reach 70%, and standing over night filters, filtrate recycling ethanol, being concentrated into relative density is 1.10～1.20/65 ℃, and adds 2.5 parts of sodium benzoate, stir concentrated solution B; (4) Borneolum Syntheticum and volatile oil are dissolved in right amount with ethanol and tween 80, add concentrated solution B, add water, stir evenly, standing over night filters, fill, promptly.
Flooded 0.5 hour earlier before decocting with water in the described step of above-mentioned preparation method (2), add 8 times of amounts of water for the first time, add 6 times of amounts of water for the second time, boiled 2 hours at every turn.
The present invention compared with prior art has following advantage: by pharmacodynamics and clinical studies show, washing liquid of the present invention can suppress the growth of pathogenic bacterium, and the inflammation-inhibiting reaction reduces inflammation secretions, improves symptom of vagina pruritus; Its function with cure mainly: but be the external-use lotion of heat clearing and damp drying, killing parasites for relieving itching, be used for damp and hot, the worm leukorrhagia due to evil, the cloudy overworked auxiliary treatment that waits disease; Confirm its curative effect certainly by clinical practice, and, can significantly improve patients ' life quality for the patient takes like a shot.
The specific embodiment
Below in conjunction with embodiment the present invention is described in further detail, but does not constitute any limitation of the invention.
Embodiment 1
Prescription:
Cortex Meliae 270g, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 270g, Fructus Cnidii 170g, Rhizoma Osmundae 270g, Caulis Fibraureae 80g, Fructus Kochiae 170g, Folium Baeckeae 270g, Radix Sophorae Flavescentis 170g, Borneolum Syntheticum 0.18g.
Preparation method:
(1) get Folium Baeckeae, Fructus Cnidii extraction volatile oil, the aqueous solution after distillation device is in addition collected, and volatile oil and aqueous solution are standby.
(2) Folium Baeckeae, Fructus Cnidii medicinal residues and all the other Rhizoma Osmundae, Caulis Fibraureae, Radix Sophorae Flavescentis, the Fructus Kochiae, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi), the Cortex Meliae Six-element behind the extraction volatile oil, decoct with water secondary, flooded 0.5 hour earlier before decocting, add 8 times of amounts of water for the first time, for the second time add 6 times of amounts of water, boiled 2 hours at every turn; Aqueous solution after collecting decoction and the distillation filters, and filtrate is concentrated into the concentrated solution A that relative density is about 1.20/65 ℃.
(3) concentrated solution A adds ethanol and makes and contain alcohol amount and reach 70%, and standing over night filters, filtrate recycling ethanol, being concentrated into relative density is 1.10～1.20/65 ℃, and adds sodium benzoate 2.5g, stir concentrated solution B.
(4) Borneolum Syntheticum and above-mentioned volatile oil are dissolved with adequate amount of ethanol and tween 80, add concentrated solution B, add water to 1000ml, stir evenly, standing over night filters, fill, promptly.
Embodiment 2
Prescription:
Cortex Meliae 350g, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 350g, Fructus Cnidii 220g, Rhizoma Osmundae 350g, Caulis Fibraureae 110g, Fructus Kochiae 220g, Folium Baeckeae 350g, Radix Sophorae Flavescentis 220g, Borneolum Syntheticum 0.22g.
Preparation method is with embodiment 1.
Embodiment 3
Prescription:
Cortex Meliae 300g, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 300g, Fructus Cnidii 200g, Rhizoma Osmundae 300g, Caulis Fibraureae 100g, Fructus Kochiae 200g, Folium Baeckeae 300g, Radix Sophorae Flavescentis 200g, Borneolum Syntheticum 0.20g.
Preparation method is with embodiment 1.
Experimental example 1
Pharmacological research
1, antiinflammatory action: be coated with this product 2ml/kg outward for mice, can alleviate the auricle edema that Oleum Tiglii causes.The rat foot that on Carrageenan causes is swollen, and tangible antiinflammation is also arranged.
2, analgesic test: be coated with this product 10ml/kg outward for mice, the mice hot plate is caused pain tangible analgesic effect, and photo-thermal is caused pain also certain analgesia trend.
3, the Cavia porcellus due to the histamine phosphate is licked sufficient reaction, be coated with this product 10ml/kg outward, tangible itching-relieving action is arranged.
4, this product 10ml/kg can suppress SDH, and prompting may have certain curative effect to some skin hypersensitivity illness.
5, this product is external all has stronger bacteriostasis to bacterium such as golden Portugal, green pus, large intestine, typhoid fever, first chain, will he formula, white thought, aerogenesis, tetanus and pneumonia.MIC is all greater than 1: 32, and is wherein particularly responsive to typhoid fever, first chain and shigella, MIC 〉=1: 1024.
Experimental example 2
Acute toxicity
Guinea pig skin administration maximum tolerated dose greater than 15ml/kg (two times of dopes), is equivalent to plan 250 times with clinical daily dose (0.12ml/kg).Mice ig administration maximum tolerated dose is greater than 40ml (two times of dopes)/kg, is 667 times of the clinical daily dose of external.
Experimental example 3
Long term toxicity
Be coated with two times of dense medicinal liquid 10ml/kg outward for rat, for intending 167 times with clinical daily dose; Two times of solution 2ml/kg of rat vagina administration are for intending 67 times with clinical daily dose.Be and be administered once every day, continuous 21 days, all animals activity, appetite, feces, local skin nonirritant were carried out for 2 weeks in test.
Experimental example 4
Data is summed up in clinical trial
1, this strain Chinese medicine for outer use through 120 routine clinical observations, and is made positive control with FUYINJIE washing liquid 60 examples.The result proves that this product all has better therapeutic effect to damp-heat vaginal discharge and wind heat blood-heat syndrome pruritus caused by wind pathogen.Diseases such as treatment back profuse leukorrhea, yellow skin, smelly dirty, pudendum or skin pruritus are improved obviously (P＜0.01 sees Table 1), and prompting this product has heat-clearing and toxic substances removing, the effect of dehumidifying parasite killing, antalgesic-antipruritic.
2, leukorrhagia patient treatment group 60 examples, matched group 30 examples, all have clear improvement (P＜0.01, tables 2,3) such as infusorian, mycete, WBC, pyocytes point out two groups of medicines that infusorian, mycete and general antibacterial are all had inhibitory action in the vaginal secretions of treatment back.
3, this organizes 120 examples, and treatment belt total effective rate following and pruritus caused by wind pathogen is respectively 91.7% and 78.3%.Matched group 50 examples, treatment belt total effective rate following and pruritus caused by wind pathogen is respectively 96.6% and 90%.Two groups are not more all had significant difference (P＞0.05 sees Table 4), and prompting this product treatment belt is consistent with FUYINJIE with the pruritus caused by wind pathogen curative effect down.
4, this product is safe and reliable, no obvious adverse reaction and toxic and side effects.
Table 1 is seen before and after the disease integration treatment relatively (X ± SD)
The vaginal secretions anomaly ratio is than (Ridit analysis) before and after the treatment of table 2 treatment group
The vaginal secretions anomaly ratio is than (Ridit analysis) before and after table 3 treatment of control group
Table 4 treatment group and matched group curative effect be (Ridit analysis) relatively
Experimental example 5
The feature case
1, Xiao, women, 23 years old, main suit, profuse leukorrhea, 3 weeks of yellow skin.Look into: ordinary circumstance is good, red tongue, tongue fur BOHUANG, rapid pulse.Woman inspection: pudendum is normal, and the vagina cervix uteri is smooth, the uterus prosposition, and in normal big, the matter, adnexa is normal, leukorrhagia amount II level.Vaginal secretions is checked: infusorian (-), mycete (-), WBC (-), pyocyte (+).Vagina cleanness degree II °.Tcm diagnosis: leukorrhagia (damp-heat syndrome).Western medicine diagnose: nonspecific vaginitis.Give this product treatment, medicinal liquid is used the vaginal douche washing vagina for 5 times with the dilution of eliminating cold for resuscitation water, every day 1 time, logotype is checked above-mentioned each disease and is disappeared after 7 days, and the vaginal secretions inspection is normal.Efficacy evaluation: cure in the recent period.
2, revive certain, the woman, 24 years old, left elbow and 2 weeks of right leg skin pruritus, disease saw, and left elbow and right leg skin pruritus, vexed dormancy are poor, and local scratch is neat, no blood crusts, red tongue, thin white fur of tongue, thready pulse.Tcm diagnosis: pruritus caused by wind pathogen (wind heat blood-heat syndrome).Western medicine diagnose: skin pruritus card.Give this product treatment, directly put medicinal liquid on the skin affected part outward, every day 3 times.Medication after 3 days skin pruritus obviously alleviate, scratch is few and irregular, pruritus disappeared substantially in 7 days, no scratch.Efficacy evaluation: produce effects.
3, Wei so-and-so, the woman 35 years old, examines because of itching of vulva shows effect in not healing February repeatedly.Coming once to be the outer court before the institute does not always prove effective with treatments such as JIEERYIN.The equal flushing of the big nympha perineal position of gynecologial examination pudendum is dispersed in the ulcer point, the how yellow stink of secretions.Red tongue, yellow fur, rolling pulse are thin; The laboratory is checked: the secretions leukocyte ++, pyocyte+.Be diagnosed as vulvitis (ulcer).Give this product flushing and sit basin, check symptom over 3 days and be clearly better.Examine symptomatology over the 7th day and disappear, the laboratory checks that leukocyte, pyocyte are all negative.Efficacy evaluation, recovery from illness.
4, ancient so-and-so, woman, 26 years old.Because of pruritus vulvae, pain outbreak month surplus examining repeatedly.Come once to use medical herbs washout (what medicine is not clear) and condy to sit basin before the institute, not better.The equal flushing of pudendum and vaginal wall, secretions is few.The laboratory check leukocyte and pyocyte respectively have+, red tongue, yellow fur, rolling pulse.Be diagnosed as vaginitis.Give this product flushing and sit the 3rd day further consultation sx behind the basin, symptom disappeared entirely in the 7th day, and the laboratory is checked no abnormal.Efficacy evaluation is recovery from illness.
Claims (4)
1. Chinese medicine washing liquid that is used for the treatment of leukorrhagia, pudendal pruritus disease, it is characterized in that this washing liquid is the water preparation of being made by the raw material of Chinese medicine of following weight parts, 270～350 parts of Cortex Meliaees, 270～350 parts of Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi)s, 170～220 parts of Fructus Cnidiis, 270～350 parts of Rhizoma Osmundae, 80～110 parts of Caulis Fibraureaes, 170～220 parts of the Fructus Kochiae, 270～350 parts of Folium Baeckeaes, 170～220 parts of Radix Sophorae Flavescentiss, 0.18～0.22 part of Borneolum Syntheticum.
2. according to the described Chinese medicine washing liquid that is used for the treatment of leukorrhagia, pudendal pruritus disease of claim 1, the weight portion that it is characterized in that raw material of Chinese medicine is 285～335 parts of Cortex Meliaees, 285～335 parts of Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi)s, 180～210 parts of Fructus Cnidiis, 285～335 parts of Rhizoma Osmundae, 85～105 parts of Caulis Fibraureaes, 180～210 parts of the Fructus Kochiae, 285～335 parts of Folium Baeckeaes, 180～210 parts of Radix Sophorae Flavescentiss, 0.19～0.21 part of Borneolum Syntheticum.
3. according to the described preparation method that is used for the treatment of the Chinese medicine washing liquid of leukorrhagia, pudendal pruritus disease of claim 1, it is characterized in that comprising the steps: that (1) gets Folium Baeckeae, Fructus Cnidii extracts volatile oil, the aqueous solution after distillation device is in addition collected; (2) Folium Baeckeae, Fructus Cnidii medicinal residues and all the other Rhizoma Osmundae, Caulis Fibraureae, Radix Sophorae Flavescentis, the Fructus Kochiae, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi), the Cortex Meliae Six-element behind the extraction volatile oil, decoct with water secondary, aqueous solution after collecting decoction and the distillation filters, and filtrate is concentrated into the concentrated solution A that relative density is about 1.20/65 ℃; (3) concentrated solution A adds ethanol and makes and contain alcohol amount and reach 70%, and standing over night filters, filtrate recycling ethanol, being concentrated into relative density is 1.10～1.20/65 ℃, and adds 2.5 parts of sodium benzoate, stir concentrated solution B; (4) Borneolum Syntheticum and volatile oil are dissolved in right amount with ethanol and tween 80, add concentrated solution B, add water, stir evenly, standing over night filters, fill, promptly.
4. according to the described preparation method that is used for the treatment of the Chinese medicine washing liquid of leukorrhagia, pudendal pruritus of claim 3, it is characterized in that: flooded 0.5 hour earlier before decocting with water in the step (2), add 8 times of amounts of water for the first time, add 6 times of amounts of water for the second time, boiled 2 hours at every turn.
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| CN200710029682A CN100586447C (en) | 2007-08-10 | 2007-08-10 | Chinese medicine wash liquid used for treating leucorrhea, pruritus vulvae etc. |
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| CN200710029682A CN100586447C (en) | 2007-08-10 | 2007-08-10 | Chinese medicine wash liquid used for treating leucorrhea, pruritus vulvae etc. |
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| CN100586447C true CN100586447C (en) | 2010-02-03 |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101417068B (en) * | 2008-11-25 | 2010-12-22 | 山西振东制药有限公司 | Traditional Chinese medicine bacteriostatic lotion and preparation method thereof |
| CN103393750B (en) * | 2013-08-04 | 2015-01-21 | 段美玲 | Traditional Chinese medicine smoked lotion for senile vaginitis |
| CN103495053A (en) * | 2013-09-25 | 2014-01-08 | 合肥智上农业开发有限公司 | Disinfectant with lavender fragrance |
| CN103520593B (en) * | 2013-10-03 | 2015-06-24 | 青岛市市立医院 | Chinese herba preparation for treating trichomonas vaginitis and preparation method thereof |
| CN104906460A (en) * | 2015-05-31 | 2015-09-16 | 广西德联制药有限公司 | Compound herba fibraureae recisae lotion and preparation method thereof |
| CN105748827A (en) * | 2016-04-11 | 2016-07-13 | 唐家婷 | Traditional Chinese medicinal washing liquid for treating vaginitis |
| CN108704053A (en) * | 2018-07-25 | 2018-10-26 | 步源堂生物科技有限公司 | A kind of special gynaecologic washing lotion of pregnant woman |
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Address after: 510650, Condie building, 2 Yuan Gang Avenue, Guangzhou, Guangdong, Tianhe District Patentee after: Guangdong Baorui Tanzania Pharmaceutical Group Co. Ltd Address before: 510650, Condie building, 2 Yuan Gang Avenue, Guangzhou, Guangdong, Tianhe District Patentee before: Guangzhou Kadear Pharmaceutical Co., Ltd. |