CN105106304A - Traditional Chinese medicine compound preparation for treating gynecological inflammations and preparation method thereof - Google Patents
Traditional Chinese medicine compound preparation for treating gynecological inflammations and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine compound preparation for treating gynecological inflammations, made with red-rooted Salvia root and lightyellow Sophora root. The traditional Chinese medicine compound preparation comprises red-rooted Salvia root extract and lightyellow Sophora root extract; the red-rooted Salvia root extract includes effective ingredients, salvianolic acid b and tanshinone IIA; the lightyellow Sophora root includes an effective ingredient, oxymatrine; the content of the salvianolic acid b is not less than 5%, and the content of the tanshinone IIA is not less than 0.2%; the content of the oxymatrine is at least 2%. The traditional Chinese medicine compound preparation is applicable to treating gynecological diseases such as wart, cervicitis, vaginitis or the like, and has the functions of promoting subsidence of inflammations and erosion areas, killing HPV virus, killing germs to stop itching and the like, thereby achieving curing; the traditional Chinese medicine compound preparation is convenient to use and has no any bad effect; a formula of the traditional Chinese medicine compound preparation is simple, the cost is low, and the traditional Chinese medicine compound preparation is suitable for large-scale production and convenient to use and has outstanding therapeutic effect; the traditional Chinese medicine compound preparation has a stable quality system and clear effective ingredients.
Description
Technical field
The present invention relates to a kind of compound Chinese medicinal preparation, especially relate to one and be used for the treatment of various gynaecopathia, as the medicine and preparation method thereof of the prevention of vaginitis, cervical erosion, HPV virus, tumor.
Background technology
At present, gynaecopathia such as pelvic inflammatory disease, adnexitis, endometritis, cervicitis, vaginitis and hysteromyoma etc. are all frequently-occurring diseases of comparatively commonly encountered diseases on gynecological clinic, chronic cervicitis refers to the Lymph nodes that woman cervix uteri occurs, acute cervicitis is comparatively rare, but treat not in time, just may become chronic cervicitis.Clinical cardinal symptom is patient uterine's cervical region redness, pain, cervical erosion, cervical hypertrophy, cervical polyp, Naboth's cysts, inflammation of cervical canal etc.Clinical treatment chronic cervicitis is comparatively thorny, and existing drug treatment, as oral anti-inflammatory drug or Western medicine transfusion, is cured the symptoms, not the disease, do not reached the object for the treatment of; Existing physical therapy modalities, as leep knife treatment, LEEP cutter less invasive techniques and laser therapy etc., though cure rate is high, having very large side effect, giving birth to as affected patient in the future.And herbal treatment is China's civilization transfer for thousands of years, fundamentally cure diseases.And Radix Salviae Miltiorrhizae, be the root of Chun Xing section herbaceos perennial Radix Salviae Miltiorrhizae.According to effect, being usually used in: blood circulation promoting and blood stasis dispelling, is the disease suffered from for multiple blood stasis; Removing heat from blood eliminating carbuncle, demonstrate,proves for carbuncle sore tumefacting virus; Relieving restlessness is calmed the nerves, and enters nutrient blood, the cards such as dysphoria and insomnia for epidemic febrile disease heat.Radix Sophorae Flavescentis is the plant that pulse family Radix Sophorae Flavescentis belongs to.Another name: matrine, Chinese scholartree, water Chinese scholartree, Tu Chinese scholartree, proud Chinese scholartree, wild Chinese scholartree or white stem.Be distributed in the ground such as each provinces and regions, north and south of Russia, Japan, India, Korea and China's Mainland, be grown on height above sea level 1, the area of 500 meters, how raw in hillside, sand ground, Cao Po, spinney and near field, at present not yet by artificial introducing and planting.Function cures mainly: heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.
Also the Chinese drugs agentia of many treatment gynaecopathias is had at present, but current Chinese drugs agentia types of medicines is many, and effect decreases on the contrary, therefore, require further improvement Chinese drugs agentia now, the compound Chinese medicinal preparation of simple, the eutherapeutic treatment gynecological inflammation of a kind of formula is provided.
Summary of the invention
The technical problem to be solved in the present invention is, for existing deficiency, provide that a kind of formula is simple, good effect have promote inflammation, rotten to the corn face disappears, and kills the compound Chinese medicinal preparation of the treatment gynecological inflammation of the functions such as hpv virus, sterilizing and itch-relieving.
In order to solve the problems of the technologies described above, the technical solution used in the present invention is, the raw material of the compound Chinese medicinal preparation of this treatment gynecological inflammation is Radix Salviae Miltiorrhizae and Radix Sophorae Flavescentis, and its composition comprises Radix Salviae Miltiorrhizae extract and Radix Sophorae Flavescentis extract, and the effective ingredient of described Radix Salviae Miltiorrhizae extract is salvianolic acid b and tanshinone ⅡA; The effective ingredient of described Radix Sophorae Flavescentis extract is oxymatrine; Content >=5% of described salvianolic acid b, content >=0.2% of described tanshinone ⅡA; The content of described oxymatrine is at least 2%.
Inventor is through repeatedly studying discovery, Radix Salviae Miltiorrhizae acid b has sterilization, blood circulation promoting and blood stasis dispelling, improves the function such as microcirculation, scavenging free radicals, tanshinone ⅡA has bactericidal antiphlogistic effect, blood circulation promoting and blood stasis dispelling function can be produced and the blood circulation in wound portion can be improved, promoting the metabolic effect of affected skin; Radix Sophorae Flavescentis has heat clearing and damp drying, parasite killing, the functions such as diuresis; For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.Three is made composite drug according to suitable ratio, not only have and promote to disappear in inflammation, rotten to the corn face, kill the functions such as hpv virus, sterilizing and itch-relieving, and Radix Salviae Miltiorrhizae Radix Sophorae Flavescentis two medicine share and has synergism, thus effect of blood circulation promoting and blood stasis dispelling, dispersing swelling and dissipating binds, heat-clearing and toxic substances removing improves greatly, thus reach the object of recovery from illness, and this Chinese medicine preparation uses simple operation, without any untoward reaction.
The present invention improves further and is, the parts by weight proportioning of described Radix Salviae Miltiorrhizae and Radix Sophorae Flavescentis is 9 ~ 1:1 ~ 5.
As preferred version of the present invention, the parts by weight proportioning of described Radix Salviae Miltiorrhizae and Radix Sophorae Flavescentis is 3:1.
The present invention improves further and is, the compound Chinese medicinal preparation of this treatment gynecological inflammation is external preparation.For skin mucosa; Also medicine, medical instruments product or sterile products can be made.
As preferred version of the present invention, the compound Chinese medicinal preparation of this treatment gynecological inflammation makes lyophilized powder or ointment or ointment or paste or gel or suppository or tablet or capsule or liquid agent or membrane.
As preferred version of the present invention, the compound Chinese medicinal preparation of this treatment gynecological inflammation makes tablet or suppository or membrane or powder or liquid agent or gel.Making tablet or suppository or membrane or powder or liquid agent or gel uses more convenient.
The compound Chinese medicinal preparation of this treatment gynecological inflammation is applied to the prevention for the treatment of vaginitis or cervical erosion or HPV virus or tumor.
The technical problem that the present invention also will solve is, for existing deficiency, provides a kind of and has the preparation method that the low and formula of cost simply treats the compound Chinese medicinal preparation of gynecological inflammation.
In order to solve the problems of the technologies described above, the technical solution used in the present invention is, the preparation method of the compound Chinese medicinal preparation of this treatment gynecological inflammation, comprises the following steps:
(1) clean container: first use ethanol purge distil container, redistilled water cleaning distil container, for subsequent use;
(2) preparation of crude extract: put in distil container by after formula proportion Homogeneous phase mixing by Radix Salviae Miltiorrhizae, Radix Sophorae Flavescentis, with ethanol three heating eluting, collects effective ingredient, processing after filtration, obtaining crude extract by extracting the effective ingredient collected;
(3) purify centrifugal: crude extract in step (2) is added in the distil container after cleaning, adds solvent and distill, then purified by ethanol, finally obtain brown color effluent, and after reclaiming the solvent in effluent, centrifugal, the aqueous solution stayed, through lyophilization, obtains pressed powder; The effective ingredient of the pressed powder obtained is salvianolic acid b content >=5%, tanshinone ⅡA content >=0.2%, oxymatrine concentration >=2%.
As preferred version of the present invention, the described solvent in described step (3) is ethanol, and the ethanol being undertaken using in purification step by ethanol is the alcoholic solution of content 50 ~ 100%.
The present invention improves further and is, also comprises after the purification and increase backflow or purification step in described step (3), and then brown color effluent, centrifugal, backflow or purification time are 2 hours, and backflow or purification number of times 3 times, adding amount of alcohol is 10 times of medical material amounts.Can to purify further like this this medicament, thus to improve drug effect.
Adopt the technical scheme of the compound Chinese medicinal preparation of production for treating gynecological inflammation of the present invention, its beneficial effect produced is: compound Chinese medicinal preparation of the present invention comprises Radix Salviae Miltiorrhizae and Radix Sophorae Flavescentis, wherein salvianolic acid b content >=5%, tanshinone ⅡA content >=0.2%, oxymatrine, content >=2%; This compound Chinese medicinal preparation is used for the treatment of wart or the gynaecopathia such as cervicitis or vaginitis, have and promote to disappear in inflammation, rotten to the corn face, kill the functions such as hpv virus, sterilizing and itch-relieving, thus reach the object of recovery from illness, and this Chinese medicine preparation uses simple operation, without any untoward reaction; Radix Salviae Miltiorrhizae Radix Sophorae Flavescentis two medicine share and plays synergism, thus effect of blood circulation promoting and blood stasis dispelling, dispersing swelling and dissipating binds, heat-clearing and toxic substances removing improves greatly; .Simultaneously this compound Chinese medicinal preparation formula simplify, with low cost, be applicable to large-scale production, easy to use, curative effect is given prominence to; This compound Chinese medicinal preparation is that quality system is stable, active ingredient is clear and definite.
Accompanying drawing explanation
Further describe below in conjunction with accompanying drawing and embodiments of the present invention:
Fig. 1 is the colposcope photo before and after the patient treatment of model case 3; Wherein before A-treatment; After B-treatment;
Fig. 2 is the colposcope photo before and after the patient treatment of model case 4; Wherein before C-treatment; After D-treatment;
Fig. 3 is the colposcope photo before and after the patient treatment of model case 5; Wherein before E-treatment; After F-treatment;
Fig. 4 is the colposcope photo before and after the patient treatment of model case 6; Wherein before G-treatment; After H-treatment;
Fig. 5 is the colposcope photo before and after the patient treatment of model case 7; Wherein before I-treatment; After J-treatment;
Fig. 6 is the colposcope photo before and after the patient treatment of model case 8; Wherein before K-treatment; After L-treatment;
Fig. 7 is the colposcope photo before and after the patient treatment of model case 9; Wherein before M-treatment; After N-treatment;
Fig. 8 is the colposcope photo before and after the patient treatment of model case 10; Wherein before O-treatment; After P-treatment;
Fig. 9 is the colposcope photo before and after the patient treatment of model case 11; Wherein before Q-treatment; After R-treatment.
Detailed description of the invention
embodiment 1:the raw material that the compound Chinese medicinal preparation for the treatment of gynecological inflammation comprises is Radix Salviae Miltiorrhizae and Radix Sophorae Flavescentis, and the parts by weight proportioning of Radix Salviae Miltiorrhizae and Radix Sophorae Flavescentis is 3:1; Its composition comprises Radix Salviae Miltiorrhizae extract and Radix Sophorae Flavescentis extract, and the effective ingredient of Radix Salviae Miltiorrhizae extract is salvianolic acid b and tanshinone ⅡA; The effective ingredient of Radix Sophorae Flavescentis extract is oxymatrine.
The preparation method of the compound Chinese medicinal preparation of above-mentioned treatment gynecological inflammation, comprises the following steps:
(1) clean container: first use ethanol purge distil container, redistilled water cleaning distil container, for subsequent use;
(2) preparation of crude extract: raw material Radix Salviae Miltiorrhizae and Radix Sophorae Flavescentis are all worn into 200 object powder, put in distil container by after formula proportion mixing, then with ethanol three heating eluting, collect effective ingredient, processing extracting the effective ingredient collected after filtration, obtaining crude extract;
(3) purify centrifugal: crude extract in step (2) is added in the distil container after cleaning, add solvent to distill, purified by ethanol again, obtain brown color effluent, and after reclaiming the solvent in effluent, then increase backflow or purify, obtain brown color effluent again, then centrifugal, the aqueous solution stayed, through lyophilization, obtains pressed powder and is this compound Chinese medicinal preparation; Wherein backflow or purification time are 2 hours, and backflow or purification number of times are 3 times, and the amount adding ethanol is 10 times of medical material amounts, and the solvent adopted is ethanol, and the ethanol used when being purified by ethanol is the alcoholic solution of content 75%.
The pressed powder obtained is detected as through prescription quality and is divided into salvianolic acid b content to be 15%, tanshinone ⅡA content 1%, oxymatrine concentration 5%.
By above-mentioned obtained pressed powder conveniently technique to make on pharmaceutics suitable lyophilized powder or ointment or ointment or paste or gel or suppository or tablet or capsule or liquid agent or membrane for patient.
embodiment 2:the raw material that the compound Chinese medicinal preparation for the treatment of gynecological inflammation comprises is Radix Salviae Miltiorrhizae and Radix Sophorae Flavescentis, and the parts by weight proportioning of Radix Salviae Miltiorrhizae and Radix Sophorae Flavescentis is 9:1; Its composition comprises Radix Salviae Miltiorrhizae extract and Radix Sophorae Flavescentis extract, and the effective ingredient of Radix Salviae Miltiorrhizae extract is salvianolic acid b and tanshinone ⅡA; The effective ingredient of Radix Sophorae Flavescentis extract is oxymatrine.
Preparation method is with embodiment 1.The pressed powder obtained is detected as through prescription quality and is divided into salvianolic acid b content to be 20%, tanshinone ⅡA content 2%, oxymatrine concentration 0.5%.
embodiment 3:the raw material that the compound Chinese medicinal preparation for the treatment of gynecological inflammation comprises is Radix Salviae Miltiorrhizae and Radix Sophorae Flavescentis, and the parts by weight proportioning of Radix Salviae Miltiorrhizae and Radix Sophorae Flavescentis is 3:2; Its composition comprises Radix Salviae Miltiorrhizae extract and Radix Sophorae Flavescentis extract, and the effective ingredient of Radix Salviae Miltiorrhizae extract is salvianolic acid b and tanshinone ⅡA; The effective ingredient of Radix Sophorae Flavescentis extract is oxymatrine.
Preparation method is with embodiment 1.The pressed powder obtained is detected as through prescription quality and is divided into salvianolic acid b content to be 10%, tanshinone ⅡA content 0.5%, oxymatrine concentration 8%.
Prove through a large amount of experiments, to be 3:1 treating the optimum of drug effect of compound Chinese medicinal preparation of gynecological inflammation for the parts by weight proportioning of Radix Salviae Miltiorrhizae and Radix Sophorae Flavescentis.
Do to prove further to externally applied formulation effect of product of the present invention below in conjunction with some concrete model cases.
model case 1:liu, female, 40 years old.Main suit: leucorrhea amount is many at ordinary times, is creamy white more, comparatively thickness, time and with bean curd slag specimen or curdled milk sample, and pudendum is very itched; Body of the tongue is light red, white and thin fur, thready and rolling pulse.
Vaginal secretions detects: cleannes (3), infusorian (1), clues cell (1), and mycete (X is fine), is diagnosed as colpitis mycotica.
Side's medicine: clean pudendum after using every day the liquid agent made by compound Chinese medicinal preparation of the present invention to dilute, and use the suppository made by compound Chinese medicinal preparation of the present invention, every vaginal suppository on the 2nd, seven days courses for the treatment of.
This patient cures for 7 days.
model case 2:journey, female, 39 years old, main suit: menstruation shifts to an earlier date sometimes, nearly March, amount in the period increased, and had clot, each lasting more than 7 days; Companion's vulva pruritus, light purplish tongue, white and thin fur, thready and rolling pulse;
B ultrasonic: uterus 8.1 × 6 × 4.1 in utero echo is owed all, and the visible 2.3x1.6 echo in rear wall place subtracts slightly group, and behind uterus visible 4.3x2.8 no echo area, and border is clear.Prompting: hysteromyoma;
Inside examine: pudendum, vagina (-), cervical hypertrophy, light, anteversion of uterus, increase as pregnant 8 weeks sizes, matter is hard, movable good, bilateral adnexa (-);
Vaginal secretions detects: cleannes (2), mycete (-), infusorian (-);
Side's medicine: the powder made by external application compound Chinese medicinal preparation of the present invention.Once-a-day.Method: with cloth bag medicament, steams after 30 minutes, is put in abdominal part 35 minutes, once-a-day.
After this patient 2 half menstrual cycle, all diseases disappear.
model case 3:lee, 32 years old, there was contact hemorrhage of cervix in main suit: leucorrhea amount is many at ordinary times, yellow skin, suffered from cervical erosion 1 year, occasionally had pudendal pruritus; Body of the tongue is light red, white and thin fur, thready and rolling pulse.
Gynecologial examination: moderate and severe cervical;
Vaginal secretions detects: cleannes (4), infusorian (-), mycete (-);
Cervix cells smears examination: prompting moderate inflammation;
Side's medicine: clean pudendum after using every day the liquid agent made by compound Chinese medicinal preparation of the present invention to dilute, and use this liquid agent, the medicine-feeding of absorbent cotton cervix uteri is adopted every 3 days, the drug application time is 15 minutes, the liquid agent made by compound Chinese medicinal preparation of the present invention is adopted to dilute 20 times of afterflush pudendums, seven days courses for the treatment of before medicine-feeding.
This patient medication is after 30 days, and symptom has had obvious improvement, uses the suppository vaginal suppository made by compound Chinese medicinal preparation of the present invention instead, and after turunda 3 menstrual cycle, check, the smooth pinkiness of cervix uteri, points out all diseases to disappear; Colposcope photo before and after this patient treatment, as Fig. 1.
model case 4:chen, 29 years old, main suit: leucorrhea amount is many at ordinary times, yellow skin, contactless property hemorrhage of cervix, suffers from cervical erosion half a year, occasionally has pudendal pruritus; Body of the tongue is light red, white and thin fur, thready and rolling pulse.
Gynecologial examination: moderate cervical erosion;
Vaginal secretions detects: cleannes (4), infusorian (2), mycete (-);
Cervix cells smears examination: prompting moderate inflammation;
Side's medicine: clean pudendum after using every day the liquid agent made by compound Chinese medicinal preparation of the present invention to dilute, and use the suppository made by compound Chinese medicinal preparation of the present invention, every vaginal suppository on the 2nd, the liquid agent made by compound Chinese medicinal preparation of the present invention is adopted to dilute 20 times of afterflush pudendums, seven days courses for the treatment of before turunda.
After this patient medication 1 menstrual cycle, symptom has had obvious improvement, and after medication 2 menstrual cycle, check, the smooth pinkiness of cervix uteri, points out all diseases to disappear; Colposcope photo before and after this patient treatment, as Fig. 2.
model case 5:wear certain, 35 years old, main suit: leucorrhea amount is many at ordinary times, yellow skin, contactless property hemorrhage of cervix, suffers from cervical erosion 8 months, occasionally has pudendal pruritus; Body of the tongue is light red, white and thin fur, thready and rolling pulse.
Gynecologial examination: moderate cervical erosion;
Vaginal secretions detects: cleannes (3), infusorian (-), mycete (-);
Cervix cells smears examination: prompting mild inflammation;
Side's medicine: clean pudendum after using every day the liquid agent made by compound Chinese medicinal preparation of the present invention to dilute, and use the suppository made by compound Chinese medicinal preparation of the present invention, every vaginal suppository on the 2nd, the liquid agent made by compound Chinese medicinal preparation of the present invention is adopted to dilute 20 times of afterflush pudendums, seven days courses for the treatment of before turunda.
This patient medication is after 20 days, and symptom has had obvious improvement, and after medication 2 menstrual cycle, check, the smooth pinkiness of cervix uteri, points out all diseases to disappear; Colposcope photo before and after this patient treatment, as Fig. 3.
model case 6:wang, 26 years old, main suit: leucorrhea amount is many at ordinary times, and color is yellowish, contactless property hemorrhage of cervix, suffers from cervical erosion 5 months; Body of the tongue is light red, white and thin fur, thready and rolling pulse.
Gynecologial examination: slight cervical erosion;
Vaginal secretions detects: cleannes (2), infusorian (-), mycete (-);
Side's medicine: clean pudendum after using every day the liquid agent made by compound Chinese medicinal preparation of the present invention to dilute, and use the suppository made by compound Chinese medicinal preparation of the present invention, every vaginal suppository on the 3rd, seven days courses for the treatment of.
This patient medication is after one week, and symptom has had obvious improvement, and after medication menstrual cycle, check, the smooth pinkiness of cervix uteri, points out all diseases to disappear; Colposcope photo before and after this patient treatment, as Fig. 4.
model case 7:lee, 32 years old, occasionally there was bean curd slag specimen in main suit: leucorrhea amount is many at ordinary times, yellow skin, has contact hemorrhage of cervix, suffer from cervical erosion 2 years, with pudendal pruritus; Body of the tongue is light red, white and thin fur, thready and rolling pulse.
Gynecologial examination: moderate and severe cervical;
Vaginal secretions detects: cleannes (4), infusorian (-), mycete (+), BV(+)
Cervix cells smears examination: suggest severe inflammation;
Colposcopy: moderate and severe cervical is steeped with pus;
Side's medicine: the liquid agent made by compound Chinese medicinal preparation of the present invention and suppository with the use of, pudendum is cleaned after using every day the liquid agent made by compound Chinese medicinal preparation of the present invention to dilute, and use this liquid agent, the medicine-feeding of absorbent cotton cervix uteri is adopted every 3 days, the drug application time is 15 minutes, the liquid agent made by compound Chinese medicinal preparation of the present invention is adopted to dilute 20 times of afterflush pudendums, seven days courses for the treatment of before medicine-feeding; Use the suppository vaginal suppository made by compound Chinese medicinal preparation of the present invention, every 1 day once, and drug application liquid agent interval uses, seven days courses for the treatment of.
This patient medication is after 40 days, and symptom has had obvious improvement, and after matching medication 4 menstrual cycle, check, the smooth pinkiness of cervix uteri, points out all diseases to disappear; Colposcope photo before and after this patient treatment, as Fig. 5.
model case 8:grandson, 28 years old, occasionally there was contact hemorrhage of cervix in main suit: leucorrhea amount is many at ordinary times, yellow skin, suffers from cervical erosion 15 months; Body of the tongue is light red, white and thin fur, thready and rolling pulse.
Gynecologial examination: moderate cervical erosion;
Vaginal secretions detects: cleannes (4), infusorian (+), mycete (+);
Cervix cells smears examination: prompting moderate inflammation;
Colposcopy: moderate cervical erosion is steeped with pus;
Side's medicine: clean pudendum after using every day the liquid agent made by compound Chinese medicinal preparation of the present invention to dilute, and use the suppository made by compound Chinese medicinal preparation of the present invention, every vaginal suppository on the 2nd, the liquid agent made by compound Chinese medicinal preparation of the present invention is adopted to dilute 20 times of afterflush pudendums, seven days courses for the treatment of before turunda.
This patient medication is after 38 days, and symptom has had obvious improvement, and after medication 3 menstrual cycle, check, the smooth pinkiness of cervix uteri, points out all diseases to disappear; Colposcope photo before and after this patient treatment, as Fig. 6.
model case 9:lee, 25 years old, main suit: leucorrhea amount is many at ordinary times, colour cast is yellow, contactless property hemorrhage of cervix, suffers from cervical erosion half a year; Body of the tongue is light red, white and thin fur, thready and rolling pulse.
Gynecologial examination: light moderate cervical erosion;
Vaginal secretions detects: cleannes (2), infusorian (-), mycete (-);
Side's medicine: clean pudendum after using every day the liquid agent made by compound Chinese medicinal preparation of the present invention to dilute, and use the suppository made by compound Chinese medicinal preparation of the present invention, every vaginal suppository on the 3rd, the liquid agent made by compound Chinese medicinal preparation of the present invention is adopted to dilute 20 times of afterflush pudendums, seven days courses for the treatment of before turunda.
This patient medication is after 15 days, and symptom has had obvious improvement, and after medication 2 menstrual cycle, check, the smooth pinkiness of cervix uteri, points out all diseases to disappear; Colposcope photo before and after this patient treatment, as Fig. 7.
model case 10:liu, 30 years old, main suit: leucorrhea amount is many at ordinary times, colour cast is yellow, and contactless property hemorrhage of cervix, suffers from cervical erosion 14 months; Body of the tongue is light red, white and thin fur, thready and rolling pulse.
Gynecologial examination: moderate cervical erosion;
Vaginal secretions detects: cleannes (3), infusorian (-), mycete (-);
Cervix cells smears examination: prompting mild inflammation;
Side's medicine: clean pudendum after using every day the liquid agent made by compound Chinese medicinal preparation of the present invention to dilute, and use the suppository made by compound Chinese medicinal preparation of the present invention, every vaginal suppository on the 2nd, the liquid agent made by compound Chinese medicinal preparation of the present invention is adopted to dilute 20 times of afterflush pudendums, seven days courses for the treatment of before turunda.
This patient medication is after 25 days, and symptom has had obvious improvement, and medication is after 70 days, and check, the smooth pinkiness of cervix uteri, points out all diseases to disappear; Colposcope photo before and after this patient treatment, as Fig. 8.
model case 11:zhao, 45 years old, main suit: leucorrhea amount is many at ordinary times, yellow skin, purulence, contactless property hemorrhage of cervix, body of the tongue was light red, white and thin fur, thready and rolling pulse.
Vaginal secretions detects: cleannes (3), infusorian (-), mycete (-);
Colposcopy: cervix uteri Nabothian cyst;
Side's medicine: the liquid agent made by compound Chinese medicinal preparation of the present invention and suppository with the use of, pudendum is cleaned after using every day the liquid agent made by compound Chinese medicinal preparation of the present invention to dilute, and use this liquid agent, the medicine-feeding of absorbent cotton cervix uteri is adopted every 3 days, the drug application time is 15 minutes, the liquid agent made by compound Chinese medicinal preparation of the present invention is adopted to dilute 20 times of afterflush pudendums, seven days courses for the treatment of before medicine-feeding; Use the suppository vaginal suppository made by compound Chinese medicinal preparation of the present invention, every 1 day once, and drug application liquid agent interval uses, seven days courses for the treatment of.
This patient medication is after 45 days, and symptom has had obvious improvement, and after medication 3 half menstrual cycle, check, the smooth pinkiness of cervix uteri, points out all diseases to disappear; Colposcope photo before and after this patient treatment, as Fig. 9.
Finally, it is also to be noted that what enumerate above is only several specific embodiments of the present invention.Obviously, the invention is not restricted to above embodiment, many distortion can also be had.All distortion that those of ordinary skill in the art can directly derive from content disclosed by the invention or associate, all should think protection scope of the present invention.
Claims (10)
1. treat the compound Chinese medicinal preparation of gynecological inflammation for one kind, it is characterized in that, the raw material of the compound Chinese medicinal preparation of this treatment gynecological inflammation is Radix Salviae Miltiorrhizae and Radix Sophorae Flavescentis, and its composition comprises Radix Salviae Miltiorrhizae extract and Radix Sophorae Flavescentis extract, and the effective ingredient of described Radix Salviae Miltiorrhizae extract is salvianolic acid b and tanshinone ⅡA; The effective ingredient of described Radix Sophorae Flavescentis extract is oxymatrine; Content >=5% of described salvianolic acid b, content >=0.2% of described tanshinone ⅡA; The content of described oxymatrine is at least 2%.
2. the compound Chinese medicinal preparation for the treatment of gynecological inflammation as claimed in claim 1, it is characterized in that, the parts by weight proportioning of described Radix Salviae Miltiorrhizae and Radix Sophorae Flavescentis is 9 ~ 1:1 ~ 5.
3. the compound Chinese medicinal preparation for the treatment of gynecological inflammation as claimed in claim 2, it is characterized in that, the parts by weight proportioning of described Radix Salviae Miltiorrhizae and Radix Sophorae Flavescentis is 3:1.
4. the compound Chinese medicinal preparation of the treatment gynecological inflammation as described in any one of claim 1-3, is characterized in that, the compound Chinese medicinal preparation of this treatment gynecological inflammation is external preparation.
5. the compound Chinese medicinal preparation for the treatment of gynecological inflammation as claimed in claim 4, it is characterized in that, the compound Chinese medicinal preparation of this treatment gynecological inflammation makes lyophilized powder or ointment or ointment or paste or gel or suppository or tablet or capsule or liquid agent or membrane.
6. the compound Chinese medicinal preparation for the treatment of gynecological inflammation as claimed in claim 5, is characterized in that, the compound Chinese medicinal preparation of this treatment gynecological inflammation makes tablet or suppository or membrane or powder or liquid agent or gel.
7. the compound Chinese medicinal preparation for the treatment of gynecological inflammation as claimed in claim 6, the compound Chinese medicinal preparation of this treatment gynecological inflammation is applied to the prevention for the treatment of vaginitis or cervical erosion or HPV virus or tumor.
8. prepare a method for the compound Chinese medicinal preparation of the treatment gynecological inflammation described in any one of claim 2-7, comprise the following steps:
(1) clean container: first use ethanol purge distil container, redistilled water cleaning distil container, for subsequent use;
(2) preparation of crude extract: put in distil container by after formula proportion Homogeneous phase mixing by Radix Salviae Miltiorrhizae, Radix Sophorae Flavescentis, with ethanol three heating eluting, collects effective ingredient, processing after filtration, obtaining crude extract by extracting the effective ingredient collected;
(3) purify centrifugal: crude extract in step (2) is added in the distil container after cleaning, adds solvent and distill, then purified by ethanol, finally obtain brown color effluent, and after reclaiming the solvent in effluent, centrifugal, the aqueous solution stayed, through lyophilization, obtains pressed powder; The effective ingredient of the pressed powder obtained is salvianolic acid b content >=5%, tanshinone ⅡA content >=0.2%, oxymatrine concentration >=2%.
9. the method for the compound Chinese medicinal preparation of preparation treatment gynecological inflammation as claimed in claim 8, it is characterized in that, the described solvent in described step (3) is ethanol, and the ethanol being undertaken using in purification step by ethanol is the alcoholic solution of content 50 ~ 100%.
10. the method for the compound Chinese medicinal preparation of preparation treatment gynecological inflammation as claimed in claim 9, it is characterized in that, also comprise after the purification in described step (3) and increase backflow or purification step, and then obtain brown color effluent, centrifugal, backflow or purification time are 2 hours, backflow or purification number of times 3 times, and adding amount of alcohol is 10 times of medical material amounts.
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Application publication date: 20151202 |