CN100444889C - Chinese medicinal composition for treating mastopathy - Google Patents

Chinese medicinal composition for treating mastopathy Download PDF

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Publication number
CN100444889C
CN100444889C CNB2007100538226A CN200710053822A CN100444889C CN 100444889 C CN100444889 C CN 100444889C CN B2007100538226 A CNB2007100538226 A CN B2007100538226A CN 200710053822 A CN200710053822 A CN 200710053822A CN 100444889 C CN100444889 C CN 100444889C
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citri reticulatae
radix
treatment
chinese medicine
cyclomastopathy
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CN100998845A (en
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姚静
邢泽田
张志平
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TAILONG PHARMACEUTICAL CO Ltd HENAN
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TAILONG PHARMACEUTICAL CO Ltd HENAN
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Abstract

A Chinese medicine for treating mastoplasia and breast edema is prepared from 10 Chinese-medicinal materials including turtle shell, curcuma root, bupleurum root, prunella spike, etc.

Description

A kind of Chinese medicine composition that is used for the treatment of cyclomastopathy
Technical field
The present invention relates to the field of Chinese medicines, relate to a kind of Chinese medicine composition for the treatment of cyclomastopathy specifically.
Background technology
Cyclomastopathy is commonly encountered disease and frequently-occurring disease, and its sickness rate accounts for the first place of mastopathy.Sickness rate rose year by year in the last few years, and the age also more and more becomes younger.According to the market survey analysis, there is the women of 70%-80% that in various degree cyclomastopathy is all arranged approximately.There is report to think that in the women of city, per 20 people just have 1 people may suffer from this disease before menopause.Its main clinical characteristics is breast caking and mastalgia, and the characteristics that change with menstrual cycle or feelings will, serious harm women's physical and mental health are arranged.
Chinese medicine thinks that cyclomastopathy belongs to the traditional Chinese medical science " nodules of the breast " category, and this sick pathogeny is a hormone imbalances and by stagnation of QI due to depression of the liver, Chong and Ren channel disorder, and the expectorant stasis of blood is condensed and the dissimilar lump in breasies and the pain that form.The Therapeutic Principle of utilization hard masses softening and resolving, liver-smoothing, qi-regulating, resolving depression all can reach the purpose of fundamentally eliminating lump in breast in the treatment.
At present, doctor trained in Western medicine versatility hormone and operative treatment.Common Western medicine has hormone antagonist medicine (tamoxifen etc.), androgens medicine and prolactin antagonist medicine, but side effect is big, and medicining cycle is long, unsuitable conventional the use; And operative treatment is too big to women's strike, is difficult for being accepted by patient, only solves superficial phenomenon, and the relapse rate height.And Chinese medicine has outstanding advantage and clinical efficacy to the control of cystic hyperplasia of breast.The Chinese patent medicine of at present commercially available treatment cyclomastopathy has much, but is subjected to the restriction of research level at that time, mostly exists uncertain therapeutic efficacy fixed, and it is slow to take effect, and dose is big, and the course of treatment is long, the shortcoming that cure rate is low, and how not ideal enough clinical use is.
In addition, the Chinese medicine preparation that many description treatment cyclomastopathy are arranged in the Chinese patent, but these prescriptions or fill a prescription unreasonable, uncertain therapeutic efficacy is cut, cost an arm and a leg, preparation is complicated, does not also see that these prescriptions produce the report of good result in actual applications simultaneously, and particularly some prescriptions are not seen to be committed at all and produced or market sale.
Summary of the invention
Purpose of the present invention is just at the stagnation of QI due to depression of the liver that causes cyclomastopathy, feelings will internal injury, the stagnation of QI cause of disease such as do not relax, according to the women's physiological pathological characteristic, for the patient provides a kind of Chinese medicine composition for the treatment of cyclomastopathy.This medicine is to develop summing up on the basis of clinical experience for many years, focus on conditioning Liver and kidney, soothing liver-QI for relieving depression, hard masses softening and resolving, eleminating phlegm and freeing channels with dissipation Ruzhong addiction piece, can well overcome the weak point of present listing with veriety, be a kind of modern Chinese medicine compound preparation with better curative effect.
Purpose of the present invention can realize by following technique measures:
Raw materials of effective components composition and weight ratio thereof are in the Chinese medicine composition of treatment cyclomastopathy of the present invention: Nidus Vespae 3-20%, Pseudobulbus Cremastrae Seu Pleiones 3-20%, Carapax Trionycis 5-35%, Radix Curcumae 3-20%, Pericarpium Citri Reticulatae Viride 3-15%, Bulbus Fritillariae Thunbergii 10-25%, Radix Bupleuri 10-25%, Semen Citri Reticulatae 3-15%, Radix Rhapontici 4-16%, Spica Prunellae 10-25%.
Preferred weight proportion is as follows:
Nidus Vespae 8-15%, Pseudobulbus Cremastrae Seu Pleiones 8-15%, Carapax Trionycis 5-15%, Radix Curcumae 8-15%, Pericarpium Citri Reticulatae Viride 5-10%, Bulbus Fritillariae Thunbergii 8-15%, Radix Bupleuri 10-20%, Semen Citri Reticulatae 5-10%, Radix Rhapontici 5-10%, Spica Prunellae 10-20%.
Most preferred weight proportion is as follows:
Nidus Vespae 10-12%, Pseudobulbus Cremastrae Seu Pleiones 10-12%, Carapax Trionycis 6-8%, Radix Curcumae 10-12%, Pericarpium Citri Reticulatae Viride 6-8%, Bulbus Fritillariae Thunbergii 10-12%, Radix Bupleuri 10-14%, Semen Citri Reticulatae 6-8%, Radix Rhapontici 6-8%, Spica Prunellae 10-12%.
The Chinese medicine composition of treatment cyclomastopathy of the present invention can be made by common process and be fit to medicinal various dosage forms, and specifically described various dosage forms are any one in oral liquid, tablet, capsule, granule, pill, suspensoid, solution or the drop pill.
Its preparation method can adopt following step to realize: get above-mentioned raw materials by weight, water or aquiferous ethanol extract in the lump, and wherein Carapax Trionycis is fried in shallow oil in addition or is decocted first or pulverizes directly and is used as medicine; Perhaps earlier with Radix Bupleuri, Radix Curcumae and the Radix Rhapontici ethanol extraction with 50-90%, extracting solution reclaims ethanol to an amount of, must receive pure cream; With all the other all medicinal water extraction, the water liquid of concentration extraction merges with above-mentioned receipts alcohol cream to an amount of, obtains Chinese medicine extract again.This extract can directly be made preparation, as adds the water mixing, leaves standstill, and gets supernatant, and the adding correctives is an amount of, adds water to the preparation full dose, must treat the oral solution of cyclomastopathy.Or be mixed and made into preparation with the medicine acceptable carrier, as above-mentioned Chinese medicine extract can with mixing acceptable accessories, be prepared into various oral formulations commonly used, as tablet, capsule, granule etc.
Nodules of the breast, in originating from, young women, how because of worry impairing spleen, disgruntled damage liver, so that stagnation of QI expectorant coagulates, blood stasis checks, disharmony of Chong and Conception Channels, or with the passing of time due to the heat-transformation.Use Radix Bupleuri, Radix Curcumae dispersing the stagnated live-QI to relieve the stagnation of QI in the event side, the circulation of qi promoting removing blood stasis with potent drugs, promoting blood circulation and stopping pain is a monarch drug; Nidus Vespae dispels the wind, counteracting toxic substances, pain relieving, the Semen Citri Reticulatae promoting the circulation of QI to relieve pain, and Radix Rhapontici, Pseudobulbus Cremastrae Seu Pleiones heat-clearing and toxic substances removing, the detumescence lactogenesis, Bulbus Fritillariae Thunbergii removing heat-phlegm, powder detoxifcation are accessory drugs altogether; With Carapax Trionycis hard masses softening and resolving, YIN nourishing is moved back steaming again, Spica Prunellae clearing away liver-fire, Disperse hepatic depression, and the soothing the liver dispelling the stagnated QI of Pericarpium Citri Reticulatae Viride, change stagnate to assistant makes, long memorial liver and qi, pain relieving altogether, the merit of hard masses softening and resolving, eleminating phlegm and freeing channels.Be applicable to treatment depression of liver-QI, stagnation of QI phlegm stagnation type cyclomastopathy.
Modern pharmacy studies have shown that: the Nidus Vespae master contains compositions such as Cera Flava resin and a kind of " Nidus Vespae oil ", protein, calcium, ferrum, has antiinflammatory, antibiotic, analgesia, reduces effect such as body temperature, and clinical practice is in acute mastitis, pyogenic infection etc.; Radix Bupleuri contains multiple compositions such as saikoside, volatile oil, Radix Bupleuri polysaccharide and flavonoid, has effects such as antiinflammatory, analgesic, calm, analgesia and raise immunity; Pseudobulbus Cremastrae Seu Pleiones contains compositions such as mucus, glucomannan, colchicine, has anticancer, radiation resistance, and the spasmolytic effect has certain inhibitory action to staphylococcus and tubercule bacillus; Carapax Trionycis contains main components such as animal glue, keratin, ossein, calcium carbonate, iodine, vitamin D, has raise immunity, effect such as anticancer; Radix Curcumae contains volatile oil, curcumin etc., the effect that has blood fat reducing, cholesterol effect and suppress various pathogens; Pericarpium Citri Reticulatae Viride contains compositions such as volatile oil, Hesperidin and flavone compound, have eliminate the phlegm, antiasthmatic effect, antivirus action; Bulbus Fritillariae Thunbergii contains multiple alkaloid, has the effect of significant relieving cough and reducing sputum; Semen Citri Reticulatae contains multiple compositions such as limonene, ammidin, has the effect of analgesia, inhibition cyclomastopathy; Radix Rhapontici contains volatile oil and phenolic constituent, the immunologic function that it has remarkable antioxidation and improves cell; The Spica Prunellae master contains triterpene saponin, also contains oleanolic acid, ursolic acid, alkaloid etc., has antiinflammatory, effect such as antibiotic, the clinical cyclomastopathy that are applied to more.
Medicine of the present invention has dispersing the stagnated live-QI to relieve the stagnation of QI, hard masses softening and resolving, regulating QI to relieve pain, eleminating phlegm and freeing channels; Be used for the treatment of diseases such as depression of liver-QI, stagnation of QI phlegm stagnation type cyclomastopathy, lump in breast; The treatment cyclomastopathy there is specially good effect.Through clinical observation, this medicine to improve symptom, eliminate lump, pain palliation efficacy is definite, do not find toxicity and untoward reaction, and relapse rate is low.
The specific embodiment
The present invention is described in further detail below with reference to embodiment:
Embodiment 1
Present embodiment adopts following proportioning and processing step to realize:
Get Carapax Trionycis 6% by weight and pulverize, decoct with water twice, each 2 hours, decocting liquid device was in addition collected; Nidus Vespae 13%, Pseudobulbus Cremastrae Seu Pleiones 10%, Radix Curcumae 10%, Pericarpium Citri Reticulatae Viride 6%, Bulbus Fritillariae Thunbergii 13%, Radix Bupleuri 13%, Semen Citri Reticulatae 8%, Radix Rhapontici 8%, Spica Prunellae 13% and Carapax Trionycis medicinal residues decoct with water twice, each 1.5 hours, filter, merging filtrate, the medicinal liquid that filtrate and above-mentioned device are in addition collected merges, and is concentrated into relative density and is about 1.10-1.15 (60 ℃), left standstill 24 hours, supernatant is got in centrifugalize, it is an amount of to add correctives, add water to 1000ml, filter embedding, sterilization promptly gets oral solution.
Embodiment 2
Present embodiment adopts following proportioning and processing step to realize:
By weight Radix Bupleuri 12%, Pericarpium Citri Reticulatae Viride 8%, Radix Curcumae 10% and Radix Rhapontici 8% are pulverized, add 80% alcohol reflux 3 times, each 1 hour, reclaim ethanol to there not being the alcohol flavor, be evaporated to an amount of; Be that Nidus Vespae 12%, Pseudobulbus Cremastrae Seu Pleiones 14%, Carapax Trionycis 8%, Bulbus Fritillariae Thunbergii 10%, Semen Citri Reticulatae 8%, Spica Prunellae 10% decoct with water (wherein Carapax Trionycis is pulverized, and is decocted first 30 minutes) 3 times again with medicinal residues and all the other medicines, each 1 hour, filter merging filtrate, be evaporated in right amount, merge, add the water mixing with above-mentioned concentrated solution, leave standstill, get supernatant, the adding correctives is an amount of, add water to the preparation full dose, embedding, sterilization promptly gets oral solution.
Embodiment 3
Present embodiment adopts following proportioning and processing step to realize:
Carapax Trionycis 7% is utilized superfine communication technique, pulverize, fine powder is standby; Radix Bupleuri 12%, Radix Curcumae 12% and Radix Rhapontici 7% are pulverized, and add 75% alcohol reflux 3 times, and each 1 hour, reclaim ethanol to there not being the alcohol flavor, be evaporated to an amount of; Be that Nidus Vespae 12%, Pseudobulbus Cremastrae Seu Pleiones 12%, Pericarpium Citri Reticulatae Viride 7%, Bulbus Fritillariae Thunbergii 12%, Semen Citri Reticulatae 7%, Spica Prunellae 12% decoct with water 3 times again with medicinal residues and all the other medicines, each 1 hour, filter, merging filtrate is evaporated in right amount, merges with above-mentioned concentrated solution, dry, pulverize, add Carapax Trionycis fine powder and an amount of dextrin, the system granule, dry, incapsulate, make 1000, promptly get capsule.
The present invention is following further to set forth the beneficial effect that Chinese medicine composition of the present invention had by the clinical observation on the therapeutic effect test.
1, physical data
Accept female patient 60 examples for medical treatment, the age is at 25-55 between year.
2, diagnostic criteria
Western medicine diagnose (cyclomastopathy), Chinese medical discrimination (stagnation of QI due to depression of the liver, Chong and Ren channel disorder card); Primary symptom: mastalgia, lump in breast, inferior disease: uncomfortable in chestly do not relax, susceptible to lose temper due to restlessness, weak, the menoxenia of the soreness of waist.
3, Therapeutic Method
Oral 3 times of every day, each 20ml, 20 is a course of treatment.
4, efficacy assessment standard
Recovery from illness: mastalgia disappears, lump in breast disappears; Effectively: mastalgia alleviates, lump in breast deliquescing or dwindle; Invalid: mastalgia alleviates or no change, and lump does not dwindle the person.
5, therapeutic outcome
The lighter: pain is light, and lump is little, and half course of treatment cures, and weight person: pain is obvious, and the lump area is bigger, and the half improvement course of treatment is cured to one and half courses of treatment for one.
In a word, cured person 57 examples, 3 examples take a turn for the better.Cure rate 95%, total effective rate are 100%.

Claims (5)

1, a kind of Chinese medicine composition for the treatment of cyclomastopathy is characterized in that: raw materials of effective components composition and weight ratio thereof are in this medicine: Nidus Vespae 3-20%, Pseudobulbus Cremastrae Seu Pleiones 3-20%, Carapax Trionycis 5-35%, Radix Curcumae 3-20%, Pericarpium Citri Reticulatae Viride 3-15%, Bulbus Fritillariae Thunbergii 10-25%, Radix Bupleuri 10-25%, Semen Citri Reticulatae 3-15%, Radix Rhapontici 4-16%, Spica Prunellae 10-25%.
2, the Chinese medicine composition of treatment cyclomastopathy according to claim 1 is characterized in that: raw materials of effective components composition and weight ratio thereof are in this medicine: Nidus Vespae 8-15%, Pseudobulbus Cremastrae Seu Pleiones 8-15%, Carapax Trionycis 5-15%, Radix Curcumae 8-15%, Pericarpium Citri Reticulatae Viride 5-10%, Bulbus Fritillariae Thunbergii 8-15%, Radix Bupleuri 10-20%, Semen Citri Reticulatae 5-10%, Radix Rhapontici 5-10%, Spica Prunellae 10-20%.
3, the Chinese medicine composition of treatment cyclomastopathy according to claim 2 is characterized in that: raw materials of effective components composition and weight ratio thereof are in this medicine: Nidus Vespae 10-12%, Pseudobulbus Cremastrae Seu Pleiones 10-12%, Carapax Trionycis 6-8%, Radix Curcumae 10-12%, Pericarpium Citri Reticulatae Viride 6-8%, Bulbus Fritillariae Thunbergii 10-12%, Radix Bupleuri 10-14%, Semen Citri Reticulatae 6-8%, Radix Rhapontici 6-8%, Spica Prunellae 10-12%.
4, according to the Chinese medicine composition of claim 1 or 2 or 3 described treatment cyclomastopathies, it is characterized in that: technology is made and is fit to medicinal various dosage forms routinely.
5, the Chinese medicine composition of treatment cyclomastopathy according to claim 4 is characterized in that: described various dosage forms are any one in oral liquid, tablet, capsule, granule, pill, suspensoid, solution or the drop pill.
CNB2007100538226A 2007-01-10 2007-01-10 Chinese medicinal composition for treating mastopathy Active CN100444889C (en)

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Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101224290B (en) * 2007-12-28 2010-07-14 李显成 Chinese traditional medicine for treating breast nodules and preparing method thereof
CN106138144A (en) * 2015-02-17 2016-11-23 钟森 The new application of Radix Rhapontici seu Radix Echinopsis
CN105381392A (en) * 2015-11-09 2016-03-09 王多全 Traditional Chinese medicine composition for treating breast glands lobular hyperplasia of females
CN105311283A (en) * 2015-11-30 2016-02-10 潘素荣 Preparation for treating hyperplasia of mammary glands and preparation method
CN109276684A (en) * 2017-07-19 2019-01-29 邓泽潭 A kind of oral traditional Chinese medicine composition for treating the proliferation of mammary gland

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Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
CN1248465A (en) * 1999-09-03 2000-03-29 聂翠新 Method for producing Anruneixiao medicinal liquid
CN1709288A (en) * 2004-06-17 2005-12-21 成都地奥制药集团有限公司 Medicinal composition, and its preparing method and use

Non-Patent Citations (4)

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