CN1562142A - Chinese medicinal gels for treating vaginitis, cervicitis and cervical erosion and its preparing method - Google Patents
Chinese medicinal gels for treating vaginitis, cervicitis and cervical erosion and its preparing method Download PDFInfo
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- CN1562142A CN1562142A CN 200410014698 CN200410014698A CN1562142A CN 1562142 A CN1562142 A CN 1562142A CN 200410014698 CN200410014698 CN 200410014698 CN 200410014698 A CN200410014698 A CN 200410014698A CN 1562142 A CN1562142 A CN 1562142A
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Abstract
A Chinese medicine in the form of gel for treating vaginitis, cervicities, and cervical erosion is prepared from phellodendron bark, rhubarb, arnebia root and borneol. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of prescription for the treatment of the Chinese medicine gel of vaginitis, cervicitis, cervical erosion and form (comprising consumption) and preparation method.
Background technology
Gynecological inflammations such as vaginitis, cervicitis, cervical erosion are the women of child-bearing age's commonly encountered diseases, frequently-occurring disease, and sickness rate accounts for the women of child-bearing age's 60% to 80%.At present, there are many Western medicine to can be used for the treatment of vaginitis, cervicitis, cervical erosion, but the defective of Western medicine is apparent in view, as act on single, easily develop immunity to drugs, zest, anaphylaxis, internal organs such as Liver and kidney there is bigger toxic and side effects, being unsuitable for anemia of pregnant woman or women breast-feeding their children uses, intravaginal profitable strain (as lactobacillus) had killing action equally, easily cause the intravaginal dysbacteriosis, destroy self-cleaning system of vagina or the like, some medicine itself may be carcinogenic in addition, the potential danger of teratogenesis (as metronidazole etc.).
Many deficiencies of chemical medicine both can have been overcome by the compound Chinese medicinal preparation of theory of Chinese medical science prescription, the incomparable many-sided therapeutical effect of chemical medicine (invigorate blood circulation as putrefaction-removing granulation-promoting, dampness removing etc.) can be brought into play again, the former caused gynecological inflammation that causes a disease such as antibacterial, fungus, protozoon, chlamydia, mycoplasma can be widely used in.Modern disease Neo-Confucianism thinks that human papillomavirus, herpesvirus especially II herpes simplex virus type are one of main inducing of cervical cancer, and Chinese medicine will be better than Western medicine far away to the comprehensive inhibitory action of virus.Therefore, aspect the treatment gynecological inflammation, the exploitation determined curative effect, the pure Chinese medicinal preparation of dosage form novelty has vast market prospect.Yet, make a general survey of the Chinese medicine preparation of employed clinically treatment gynecological inflammation at present, as health woman antiinflammatory bolt, control rotten effervescence tablet etc., at the treatment vaginitis, cervicitis, all there is certain curative effect aspects such as cervical erosion, but kind is single generally, indication is narrower, and dosage form is outmoded, some medicine because of the development time early, preparation technology, quality standard is all relatively backward, dosage is bigger than normal, use inconvenience, and pharmacological basis is unsturdy, the pharmacodynamics index imperfection, what have does not reach desired therapeutic effect because of the adjuvant quality passes a test, and the performance that all these has directly influenced the Chinese medicine advantage has weakened the competitiveness of Chinese medicine on gynecological market.In view of this, be necessary that very exploitation can overcome the defective of many Western medicine, can remedy the gynecological insufficient of new generation good medicine of similar Chinese medicine again, to benefit numerous women.
Summary of the invention
In order to overcome the defective of the many Western medicine that are used for vaginitis, cervicitis, cervical erosion at present, can remedy the deficiency of similar Chinese medicine again and the prescription of having invented a kind of Chinese medicine gel is formed and preparation method.
Technical scheme of the present invention is that it consists of: Cortex Phellodendri 0.1～5g, Radix Et Rhizoma Rhei 0.1～5g, Radix Arnebiae (Radix Lithospermi) 0.1～5g, Borneolum Syntheticum 0.01～3g, heat clearing and damp drying, parasite killing diuretic 0.1～5g.
Wherein, gel-type vehicle is a carbomer; Heat clearing and damp drying, parasite killing diuretic are Radix Sophorae Flavescentis.
Preparation method is: Cortex Phellodendri granule and heat clearing and damp drying, parasite killing diuretic granule are merged, and mixing use the ethanol percolation, the collection percolate, and reclaim under reduced pressure ethanol and the relative density that is concentrated into regulation get (1); Radix Et Rhizoma Rhei granule and Radix Arnebiae (Radix Lithospermi) granule are merged, and mixing use the ethanol percolation, the collection percolate, and reclaim under reduced pressure ethanol and the relative density that is concentrated into regulation get (2); (1) and (2) be heated to respectively boil, filter, the filtrate spray drying after the precipitate dried under reduced pressure, is pulverized, and sieves, and merges with spray drying powder; Above each several part medicated powder and reducing swelling and alleviating pain medicine fine powder are merged, and mixing sieves, and adds in the gel-type vehicle and makes gel.
When Cortex Phellodendri granule and heat clearing and damp drying, parasite killing diuretic granule usefulness ethanol percolation, alcohol concentration is 50～70% (volumetric concentrations); When Radix Et Rhizoma Rhei granule and Radix Arnebiae (Radix Lithospermi) granule were used the ethanol percolation, alcohol concentration was 80～95% (volumetric concentrations); The used host material of gel is a carbomer.
Gel is a kind of ointment shape preparation of making as substrate with some water-soluble high-molecular materials, and easy to use, onset is rapid, be convenient to clean, compare with effervescent tablet with suppository, it is not subjected to the influence of body temperature or vagina humidity, can fill whole vagina, not stay the dead angle.Owing to be water-soluble base, medicine can contact closely with vaginal mucosa, and drug release rate is very fast, and can be in whole vagina and uterus neck performance drug effect.
Modern chemistry and pharmaceutical research show, main component in the Cortex Phellodendri is to be the alkaloids of representative with berberine, palmatine, jateorhizine, these compositions all have inhibitory or killing effect to antibacterial such as staphylococcus aureus, Streptococcus viridans, dysentery bacterium, trichophyton, acrothesium floccosum, trichophyton, Du Ang Shi sporidiole bacteria difficult to understand, epidermophyton inguinale and fungus, and leptospira, trichomonas vaginitis are also killed or inhibitory action.It is a series of alkaloids compositions of representative that Radix Sophorae Flavescentis mainly contains with matrine, oxymatrine, and Radix Sophorae Flavescentis total alkaloids has stronger inhibitory or killing effect to pathogen such as tubercule bacillus, vibrio cholera, leprosy bacillus, skin pathomycete and leptospira.Radix Et Rhizoma Rhei mainly contains free type and combined anthraquinone compounds, glycoside as emodin, chrysophanol, chrysophanic acid, physcione and mentioned component, in addition, also contain a certain amount of tannin constituents, the dissociated anthraquinone constituents all has stronger inhibitory or killing effect to some gram negative bacteria and fungus, simultaneously, can also significantly reduce the permeability of blood capillary, improve its fragility, exosmose and rhatannin can reduce wound surface body fluid.Radix Arnebiae (Radix Lithospermi) mainly contains the naphthoquinone constituents, as Shikonin etc., staphylococcus aureus, escherichia coli and multiple fungus is had inhibitory action, simultaneously, can significantly reduce the permeability of blood capillary, promotes wound healing.The main component of Borneolum Syntheticum is Borneolum Syntheticum and isoborneol, and staphylococcus aureus, streptococcus, escherichia coli and pathogenic dermatophytes are all had inhibitory action
The test of pesticide effectiveness result of this product is as follows:
1, the antiinflammatory result of the test shows: this product 34g/kg dosage group xylol induced mice auricle edema has certain inhibitory action, and suppression ratio is 29.9%, with the blank group significant difference (P＜0.05) is arranged relatively.17g/kg and 34g/kg dosage group can obviously reduce the effect that histamine phosphate induced mice capillary permeability increases, and with the blank group significant difference (P＜0.05, P＜0.01) are arranged relatively.3.4g/kg, on Carrageenan causes rat paw edema behind 6.8g/kg and the 13.6g/kg dosage group self administration of medication 1h to 4h that the obvious suppression effect is arranged, and with the blank group significant difference (P＜0.05, P＜0.01) is arranged relatively.
Prompting: this product xylol, histamine phosphate and carrageenin cause inflammation all antiinflammatory action preferably.
2, the analgesic test result shows: adopt hot plate method, this product 8.5g/kg, 17g/kg, 34g/kg dosage group can obviously improve the mice pain threshold, and the analgesic activity length of holding time, and with the blank group significant difference (P＜0.05, P＜0.01) are arranged relatively.Adopt writhing method, this product 8.5g/kg, 17g/kg, 34g/kg dosage group Dichlorodiphenyl Acetate be pain caused the obvious suppression effect, can make and turn round the minimizing of body number of times, turn round the body prolongation of latency, the analgesia percentage rate is respectively 34.7%, 40.4% and 43.5%, relatively has significant difference (P＜0.05, P＜0.01) with the blank group.
Prompting: this product has stronger analgesic activity.
3, the extracorporeal bacteria inhibitor test result shows: this product has stronger bacteriostasis to standard and clinical SEPARATION OF GOLD Staphylococcus aureus, staphylococcus hominis, Bacillus alcaligenes, Candida albicans, table staphylococcus etc., and MIC is between 3.125～25mg/ml.
Prompting: this product has the good in-vitro bacteriostasis
4, antipruritic result of the test shows: this product 3.4g/kg, 6.8g/kg and 13.6g/kg dosage group can obviously improve the itch-threshold that histamine phosphate causes Cavia porcellus, relatively have significant difference (P＜0.01, P＜0.001) with model group.Prompting: this product has itching-relieving action preferably.
5, the therapeutic outcome to experimental rat cervicitis model shows: this product 0.68g/kg and 1.36g/kg dosage group are to experimental rat cervicitis model due to the 25% phenol rubber cement, transvaginal administration 10 days, can obviously reduce PGE content in uterus and the vagina tissue, relatively has significant difference (P＜0.05, P＜0.01) with model group.Total white blood cells and neutrophilic granulocyte significantly reduce, and with model group significant difference (P＜0.05) are arranged relatively.The result of histopathologic examination shows that also this product has therapeutical effect preferably to rat acute vaginitis, endometritis, wherein with middle dosage and high dose group better efficacy.
The specific embodiment
Prescription is formed: Cortex Phellodendri 0.1～5g, Radix Et Rhizoma Rhei 0.1～5g, Radix Arnebiae (Radix Lithospermi) 0.1～5g, heat clearing and damp drying, Borneolum Syntheticum 0.01～3g, Radix Sophorae Flavescentis 0.1～5g.
Preparation method: Cortex Phellodendri granule and Radix Sophorae Flavescentis granule are merged, and mixing is 50～70% (volumetric concentration) ethanol percolation with concentration, the collection percolate, and reclaim under reduced pressure ethanol and the relative density that is concentrated into regulation get (1).Radix Et Rhizoma Rhei granule and Radix Arnebiae (Radix Lithospermi) granule are merged, and mixing is 80～95% (volumetric concentration) ethanol percolation with concentration, the collection percolate, and reclaim under reduced pressure ethanol and the relative density that is concentrated into regulation get (2).(1) and (2) be heated to respectively boil, filter, the filtrate spray drying after the precipitate dried under reduced pressure, is pulverized, and sieves, and merges with spray drying powder.Above each several part medicated powder and reducing swelling and alleviating pain medicine fine powder are merged, and mixing sieves, and adds to contain in the carbomer gel substrate.
Claims (6)
1, a kind of Chinese medicine gel for the treatment of vaginitis, cervicitis, cervical erosion, it consists of: Cortex Phellodendri 0.1～5g, Radix Et Rhizoma Rhei 0.1～5g, Radix Arnebiae (Radix Lithospermi) 0.1～5g, Borneolum Syntheticum 0.01～3g, heat clearing and damp drying, parasite killing diuretic 0.1～5g.
2, Chinese medicine gel according to claim 1 is characterized in that gel-type vehicle is a carbomer.
3, Chinese medicine gel according to claim 1 is characterized in that heat clearing and damp drying, parasite killing diuretic are Radix Sophorae Flavescentis.
4, a kind of Chinese medicine gel preparation method for the treatment of vaginitis, cervicitis, the erosion of official's neck: Cortex Phellodendri granule and heat clearing and damp drying, parasite killing diuretic granule are merged, mixing, use the ethanol percolation, collect percolate, reclaim under reduced pressure ethanol and the relative density that is concentrated into regulation get (1); Radix Et Rhizoma Rhei granule and Radix Arnebiae (Radix Lithospermi) granule are merged, and mixing use the ethanol percolation, the collection percolate, and reclaim under reduced pressure ethanol and the relative density that is concentrated into regulation get (2); (1) and (2) be heated to respectively boil, filter, the filtrate spray drying after the precipitate dried under reduced pressure, is pulverized, and sieves, and merges with spray drying powder; Above each several part medicated powder and reducing swelling and alleviating pain medicine fine powder are merged, and mixing sieves, and adds in the gel-type vehicle and makes gel.
5, preparation method according to claim 4, when it is characterized in that Cortex Phellodendri granule and heat clearing and damp drying, parasite killing diuretic granule with the ethanol percolation, alcohol concentration is 50～70% (volumetric concentrations).
6, preparation method according to claim 4, when it is characterized in that Radix Et Rhizoma Rhei granule and Radix Arnebiae (Radix Lithospermi) granule with the ethanol percolation, alcohol concentration is 80～95% (volumetric concentrations).
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200410014698 CN1562142A (en) | 2004-04-20 | 2004-04-20 | Chinese medicinal gels for treating vaginitis, cervicitis and cervical erosion and its preparing method |
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| CN 200410014698 CN1562142A (en) | 2004-04-20 | 2004-04-20 | Chinese medicinal gels for treating vaginitis, cervicitis and cervical erosion and its preparing method |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101095743B (en) * | 2007-07-18 | 2010-11-03 | 四川迪康科技药业股份有限公司 | Exterior-applied medicine composition for treating gynecologic diseases and method of making the same and the use thereof |
| CN102727705A (en) * | 2012-07-20 | 2012-10-17 | 杨献华 | Traditional Chinese medicine composition for preventing or treating cervical erosion |
| CN103989792A (en) * | 2014-06-17 | 2014-08-20 | 镇江市京口朝阳中医院有限公司 | Traditional Chinese medicinal composition for treating cervical erosion, as well as preparation method and treatment device thereof |
| CN104983983A (en) * | 2015-08-03 | 2015-10-21 | 买海涛 | Traditional Chinese medicine composition for treating gynecological disease and preparation thereof |
| CN110193051A (en) * | 2019-06-12 | 2019-09-03 | 广州梅彭健康科技有限公司 | Bacteriostatic gel and preparation method thereof |
| CN110755475A (en) * | 2019-11-27 | 2020-02-07 | 贵州泰尔医药研究所 | External preparation for treating cervicitis and preparation method thereof |
| CN110772571A (en) * | 2019-12-18 | 2020-02-11 | 河南中医药大学 | Yellow ginseng essential oil gel for treating cervical erosion |
| CN112156138A (en) * | 2020-08-06 | 2021-01-01 | 朱平 | Gynecological gel |
| CN113230392A (en) * | 2021-05-21 | 2021-08-10 | 山东译青春生物科技有限公司 | An antiviral Chinese medicinal composition for treating gynecological diseases, and its preparation method |
| CN114344386A (en) * | 2022-01-17 | 2022-04-15 | 河南萱康生物科技有限公司 | Traditional Chinese medicine composition for treating pruritus vulvae and application thereof |
| CN115581735A (en) * | 2022-10-28 | 2023-01-10 | 杭州瑞宇医疗用品有限公司 | Wash-free compound antibacterial liquid and preparation method thereof |
-
2004
- 2004-04-20 CN CN 200410014698 patent/CN1562142A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101095743B (en) * | 2007-07-18 | 2010-11-03 | 四川迪康科技药业股份有限公司 | Exterior-applied medicine composition for treating gynecologic diseases and method of making the same and the use thereof |
| CN102727705A (en) * | 2012-07-20 | 2012-10-17 | 杨献华 | Traditional Chinese medicine composition for preventing or treating cervical erosion |
| CN103989792A (en) * | 2014-06-17 | 2014-08-20 | 镇江市京口朝阳中医院有限公司 | Traditional Chinese medicinal composition for treating cervical erosion, as well as preparation method and treatment device thereof |
| CN104983983A (en) * | 2015-08-03 | 2015-10-21 | 买海涛 | Traditional Chinese medicine composition for treating gynecological disease and preparation thereof |
| CN110193051A (en) * | 2019-06-12 | 2019-09-03 | 广州梅彭健康科技有限公司 | Bacteriostatic gel and preparation method thereof |
| CN110755475A (en) * | 2019-11-27 | 2020-02-07 | 贵州泰尔医药研究所 | External preparation for treating cervicitis and preparation method thereof |
| CN110772571A (en) * | 2019-12-18 | 2020-02-11 | 河南中医药大学 | Yellow ginseng essential oil gel for treating cervical erosion |
| CN112156138A (en) * | 2020-08-06 | 2021-01-01 | 朱平 | Gynecological gel |
| CN113230392A (en) * | 2021-05-21 | 2021-08-10 | 山东译青春生物科技有限公司 | An antiviral Chinese medicinal composition for treating gynecological diseases, and its preparation method |
| CN114344386A (en) * | 2022-01-17 | 2022-04-15 | 河南萱康生物科技有限公司 | Traditional Chinese medicine composition for treating pruritus vulvae and application thereof |
| CN115581735A (en) * | 2022-10-28 | 2023-01-10 | 杭州瑞宇医疗用品有限公司 | Wash-free compound antibacterial liquid and preparation method thereof |
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