CN112156138A - Gynecological gel - Google Patents

Gynecological gel Download PDF

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Publication number
CN112156138A
CN112156138A CN202010781251.3A CN202010781251A CN112156138A CN 112156138 A CN112156138 A CN 112156138A CN 202010781251 A CN202010781251 A CN 202010781251A CN 112156138 A CN112156138 A CN 112156138A
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gel
content range
heat
lithospermum
total
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朱平
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/756—Phellodendron, e.g. corktree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/30—Extraction of the material
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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Abstract

The invention relates to the technical field of gynecological gel, in particular to gynecological gel. The feed comprises the following raw materials: glycerin, gel, heat clearing agent, blood activating agent, the rest is water, in this gynaecology's gel, through the heat clearing agent that sets up, when the patient uses, play the effect of heat-clearing and detoxicating to the affected part for patient's health resumes, the blood activating agent that sets up plays current blood vessel, the effect of resolving hard mass and removing blood stasis, the women patient's of being convenient for use.

Description

Gynecological gel
Technical Field
The invention relates to the technical field of gynecological gel, in particular to gynecological gel.
Background
The gynecological gel is used for treating various gynecological vaginitis and cervicitis, including bacterial vaginitis, trichomonas vaginitis, mixed vaginitis, gonococcus infection, chronic cervicitis, cervical erosion and the like.
Disclosure of Invention
The present invention aims to provide a gynecological gel to solve the problems mentioned in the background art.
In order to realize the aim, the invention provides gynecological gel which comprises the following raw materials: 7.5 to 12.5 portions of glycerin, 2.5 to 3.0 portions of gel, 1.0 to 2.9 portions of heat clearing agent, 5.1 to 9.5 portions of blood activating agent, and the rest is water.
As a further improvement of the technical scheme, the raw materials of the heat clearing agent comprise lithospermum, phellodendron and borneol, and the preparation method of the heat clearing agent comprises the following steps:
s1.1, grinding borneol, mixing phellodendron and lithospermum, adding water, decocting for three times, and combining the decoctions to obtain a liquid;
s1.2, filtering to obtain a liquid, concentrating the filtrate to obtain a clear paste with the relative density of 1.10, adding ethanol, and concentrating to obtain a thick paste with the relative density of 1.36;
s1.3, drying the thick paste, crushing into fine powder, adding glycerol into the fine powder, mixing, and heating to melt;
s1.4, adding the phellodendron and lithospermum synthesized fine powder, and stirring and cooling;
the heat-clearing agent in the gynecological gel can play a role in clearing heat for the affected part in the vagina.
As a further improvement of the technical scheme, the blood activating agent comprises total matrines and catechu, and the preparation method of the blood activating agent comprises the following steps:
s2.1, smashing catechu into fine powder to form infant tea powder;
s2.2, putting the total matrine into a beaker, adding 600ml of water, heating until the total matrine is completely dissolved, and adjusting the pH value to 4-5 by using dilute hydrochloric acid to form a total matrine solution;
s2.3, pouring the catechu powder into the total matrine solution, and fully stirring and mixing;
the blood activating agent in the gynecological gel can play a role in activating blood and dissolving stasis on the affected part in the vagina of a patient.
As a further improvement of the technical scheme, the gel agent is sodium carboxymethyl cellulose which is a carboxymethylated derivative of cellulose and is the most main ionic cellulose gum, the sodium carboxymethyl cellulose is white fibrous or granular powder, is odorless, tasteless and hygroscopic, and is easy to disperse in water to form a transparent colloidal solution, and the preparation method of the gel agent comprises the following steps:
s3.1, placing sodium carboxymethylcellulose in a beaker, adding glycerol, and fully and uniformly mixing;
s3.2, standing for about 30min, slowly adding the total matrine solution while stirring to be uniform;
and S3.3, standing for 1-2 hours, adding water to the full volume, uniformly stirring, placing into an infusion bottle, sealing, and sterilizing for 30min at 100 ℃ by circulating steam.
As a further improvement of the technical scheme, the content range of the lithospermum is 5-10mg/ml, the lithospermum has the functions of clearing heat and promoting diuresis, and under the conditions of some common eczemas in life, damp-heat in liver and gallbladder and the like, the lithospermum can be used as a treatment method, staphylococcus aureus and bacillus prodigiosus can be inhibited, vulvar eczema, vaginitis and cervicitis can be treated, women urogenital fistula patients have increased vaginal discharge caused by eczema, erosion and ulcer of the pudendum and various reasons due to frequent urine leakage, the lithospermum oil can take effect after being applied for about 3-5 days, the lithospermum oil is used for treating vaginitis, and the lithospermum oil can be treated well in 4-6 days after application and has low recurrence rate; the content range of the golden cypress is 3-12mg/ml, the golden cypress has the functions of clearing heat and drying dampness, purging fire and removing steaming, detoxifying and curing sores, and is used for damp-heat diarrhea and dysentery, jaundice, leucorrhea, heat stranguria, beriberi, flaccidity { exorcism }, bone steaming and internal heat, night sweat, spermatorrhea, pyogenic infections, eczema and pruritus, the salted golden cypress has the functions of nourishing yin and reducing pathogenic fire, is used for yin deficiency and fire excess, night sweat and bone steaming, and is effective on staphylococcus aureus, pneumococcus, diphtheria bacillus, viridis streptococcus, dysentery bacillus (except Song Neisseria) and the like; the content range of the borneol is 2-7mg/ml, the borneol is used for treating sore and ulcer swelling and pain, is not healed after ulceration, also has the functions of clearing away heat and toxic materials, preventing corrosion and promoting granulation, and can also promote the absorption of medicaments, because the borneol belongs to a natural transdermal enhancer, the borneol can promote the absorption and utilization of external cortical hormone and analgesic medicaments.
As a further improvement of the technical proposal, the content range of the total matrines of the lightyellow sophora root is 50-90mg/ml, the lightyellow sophora root is used for treating heat dysentery, hematochezia, jaundice anuresis, leucorrhea with reddish discharge, vulvar swelling and pruritus vulvae, eczema, skin pruritus, scabies, tinea and leprosy, has the functions of promoting blood circulation and stopping bleeding, clearing away the lung-heat and stopping cough, resisting anoxia, fatigue and cold, can improve the strength and flexibility of the organism, can quickly recover fatigue, adjust the immune system, has the bidirectional adjusting function to the functions of the brain and organs, also has the functions of promoting urination, relieving asthma, hypnotizing, resisting arrhythmia and the like, the content range of the catechu is 1-5mg/ml, the catechu is used for treating traumatic injury, traumatic hemorrhage, hematemesis and epistaxis, unhealing sores, eczema, moist sores and cough, has the functions of promoting blood circulation and relieving pain, promoting granulation and stopping bleeding, astringing dampness and healing, clearing lung-heat and eliminating phlegm.
As a further improvement of the technical scheme, the content range of the glycerol is 75-125mg/ml, and the glycerol can moisten the mucosa of the vagina, promote the penetration of the medicament and play roles in preserving moisture, thickening and lubricating.
As a further improvement of the technical scheme, the content range of the sodium carboxymethylcellulose is 25-30mg/ml, the viscosity of the gel can be adjusted along with climate change, and the situation that the sodium carboxymethylcellulose is too high or too low and is not beneficial to patients to use is avoided.
Compared with the prior art, the invention has the beneficial effects that:
1. in the gynecological gel, the heat clearing agent is convenient for clearing heat and removing toxic substances from affected parts when being used by patients, so that the body recovery of the patients is accelerated.
2. The blood activating agent in the gynecological gel has the effects of promoting blood circulation, resolving hard mass and removing blood stasis, and is convenient for female patients.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it should be apparent that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The invention provides a gynecological gel which comprises the following raw materials: 7.5 parts of glycerin, 2.5 parts of gel, 1.0 part of heat clearing agent, 5.1 parts of blood activating agent, and the balance of water.
In this embodiment, the heat-clearing agent comprises lithospermum, phellodendron amurense and borneol as raw materials, and the preparation method of the heat-clearing agent comprises the following steps:
s1.1, grinding borneol, mixing phellodendron and lithospermum and adding water to decoct for three times, decocting the phellodendron and the lithospermum in water for three times, decocting for 2 hours for the first time, and decocting for 1 hour for the second time and the third time respectively to obtain decoction;
s1.2, filtering to obtain a liquid, concentrating the filtrate to obtain a clear paste with the relative density of 1.10, adding ethanol, and concentrating to obtain a concentrated solution
For thick paste with density of 1.36;
s1.3, drying the thick paste, crushing into fine powder, adding glycerol into the fine powder, mixing, heating to melt, and keeping the temperature at 40 DEG C
±2℃；
S1.4, adding the phellodendron and lithospermum synthesized fine powder, and stirring and cooling.
Further, the blood activating agent comprises total matrines and catechu, and the preparation method of the blood activating agent comprises the following steps:
s2.1, smashing catechu into fine powder to form infant tea powder;
s2.2, putting the total matrines into a beaker, adding 600ml of water, heating until the total matrines are completely dissolved, and adjusting the pH value by using dilute hydrochloric acid
4 to 5, forming a matrine solution;
s2.3, pouring the catechu powder into the total matrine solution, and fully stirring and mixing.
Specifically, the gel is sodium carboxymethyl cellulose, which is a carboxymethylated derivative of cellulose and is the most main ionic cellulose gum, and the sodium carboxymethyl cellulose is white fibrous or granular powder, is odorless, tasteless and hygroscopic, and is easily dispersed in water to form a transparent colloidal solution, and the preparation method of the gel comprises the following steps:
s3.1, placing sodium carboxymethylcellulose in a beaker, adding glycerol, and fully and uniformly mixing;
s3.2, standing for about 30min, slowly adding the total matrine solution while stirring to be uniform;
and S3.3, standing for 1-2 hours, adding water to the full amount, uniformly stirring, placing into an infusion bottle, sealing, and sterilizing for 30min at 100 ℃ by circulating steam.
In addition, the content range of the sodium carboxymethyl cellulose is 25mg/ml, the viscosity of the gel can be adjusted along with climate change, and the content of the sodium carboxymethyl cellulose needs to be reduced in winter, so that the viscosity of the gel is convenient to stabilize.
In addition, the content range of the lithospermum is 5mg/ml, the lithospermum has the functions of clearing heat and promoting diuresis, some common eczemas in life and damp-heat in liver and gallbladder and the like can be treated by adopting the lithospermum as a treatment method, staphylococcus aureus and bacillus prodigiosus can be inhibited, vulval eczema, vaginitis and cervicitis can be treated, vaginal discharge increase caused by eczema, erosion and ulcer of pudendum and various reasons due to frequent urine leakage of female urogenital fistula patients can be treated after being coated with the lithospermum oil for about 3-5 days, the lithospermum can be used for treating vaginitis, and the treatment effect can be well realized in 4-6 days after the application of the lithospermum oil generally, and the recurrence rate is very low; the content range of the phellodendron is 3mg/ml, the phellodendron has the effects of clearing heat and drying dampness, purging fire and removing steaming, detoxifying and curing sores, and is used for damp-heat diarrhea, jaundice, leukorrhagia, heat stranguria, beriberi, flaccidity { exorcising exorcism }, bone steaming and internal heat, night sweat, spermatorrhea, pyocutaneous disease and pyogenic infections, eczema and pruritus, and the phellodendron salina has the effects of nourishing yin and reducing fire, is used for yin deficiency and fire excess, night sweat and bone steaming, and is effective on staphylococcus aureus, pneumococcus, diphtheria bacillus, viridis streptococcus, dysentery bacillus (except sonnei) and the like; the content range of the borneol is 2mg/ml, the borneol is used for treating sore and ulcer swelling and pain, can not heal after ulceration, also has the functions of clearing away heat and toxic materials, preventing corrosion and promoting granulation, and can also promote the absorption of medicaments, because the borneol belongs to a natural transdermal enhancer, the borneol can promote the absorption and utilization of external cortical hormone and analgesic medicaments.
Furthermore, the total matrines content range of the sophora flavescens is 50mg/ml, the sophora flavescens is used for treating heat dysentery, hematochezia, jaundice anuresis, leucorrhea with reddish discharge, vulva swelling and pruritus vulvae, eczema, skin pruritus, mange and leprosy, trichomonas vaginitis is externally treated, the external medicine has the functions of activating blood and stopping bleeding, clearing away the lung-heat and relieving cough, resisting anoxia, fatigue and cold, can improve the strength and flexibility of organisms, can quickly recover fatigue, regulate the immune system, has a bidirectional regulation function on brain and organ functions, and has the functions of promoting urination, relieving asthma, hypnosis, resisting arrhythmia and the like, the content range of the catechu is 1mg/ml, and the catechu is used for treating traumatic injury pain, traumatic hemorrhage, hematemesis and clearing away the lung-heat, sores and abscess are not healed, eczema, lung heat and cough, and has the effects of activating blood and relieving pain, stopping bleeding and promoting granulation, astringing dampness and eliminating phlegm.
It is worth pointing out that the content range of the glycerol is 75mg/ml, and the glycerol can moisten vaginal mucosa, promote drug permeation and play roles in moisturizing, thickening and lubricating.
Example 2
The invention provides a gynecological gel which comprises the following raw materials: 12.5 parts of glycerin, 3.0 parts of gel, 2.9 parts of heat clearing agent and 9.5 parts of blood activating agent, and the balance of water.
In this embodiment, the heat-clearing agent comprises lithospermum, phellodendron amurense and borneol as raw materials, and the preparation method of the heat-clearing agent comprises the following steps:
s1.1, grinding borneol, mixing phellodendron and lithospermum and adding water to decoct for three times, decocting the phellodendron and the lithospermum in water for three times, decocting for 2 hours for the first time, and decocting for 1 hour for the second time and the third time respectively to obtain decoction;
s1.2, filtering to obtain a liquid, concentrating the filtrate to obtain a clear paste with the relative density of 1.10, adding ethanol, and concentrating to obtain a thick paste with the relative density of 1.36;
s1.3, drying the thick paste, crushing into fine powder, adding glycerol into the fine powder, mixing, heating and melting, and keeping the temperature at 40 +/-2 ℃;
s1.4, adding the phellodendron and lithospermum synthesized fine powder, and stirring and cooling.
Further, the blood activating agent comprises total matrines and catechu, and the preparation method of the blood activating agent comprises the following steps:
s2.1, smashing catechu into fine powder to form infant tea powder;
s2.2, putting the total matrine into a beaker, adding 600ml of water, heating until the total matrine is completely dissolved, and adjusting the pH value to 4-5 by using dilute hydrochloric acid to form a total matrine solution;
s2.3, pouring the catechu powder into the total matrine solution, and fully stirring and mixing.
Specifically, the gel is sodium carboxymethyl cellulose, which is a carboxymethylated derivative of cellulose and is the most main ionic cellulose gum, and the sodium carboxymethyl cellulose is white fibrous or granular powder, is odorless, tasteless and hygroscopic, and is easily dispersed in water to form a transparent colloidal solution, and the preparation method of the gel comprises the following steps:
s3.1, placing sodium carboxymethylcellulose in a beaker, adding glycerol, and fully and uniformly mixing;
s3.2, standing for about 30min, slowly adding the total matrine solution while stirring to be uniform;
and S3.3, standing for 1-2 hours, adding water to the full amount, uniformly stirring, placing into an infusion bottle, sealing, and sterilizing for 30min at 100 ℃ by circulating steam.
In addition, the content range of the sodium carboxymethyl cellulose is 30mg/ml, the viscosity of the gel can be adjusted along with climate change, and the content of the sodium carboxymethyl cellulose needs to be increased in summer, so that the viscosity of the gel is convenient to stabilize.
In addition, the content range of the lithospermum is 10mg/ml, the lithospermum has the functions of clearing heat and promoting diuresis, some common eczemas in life and damp-heat in liver and gallbladder and the like can be used as a treatment method, staphylococcus aureus and bacillus prodigiosus can be inhibited, vulval eczema, vaginitis and cervicitis can be treated, women patients with urogenital fistula can increase vaginal discharge caused by frequent urine leakage and eczema, erosion and ulcer of the pudendum and various reasons, the lithospermum oil can take effect after being coated for about 3 to 5 days, the lithospermum oil is used for vaginitis, generally, the vaginitis can be treated in 4 to 6 days after the application, and the recurrence rate is low; the content range of the phellodendron is 12mg/ml, the phellodendron has the effects of clearing heat and drying dampness, purging fire and removing steaming, detoxifying and curing sores, and is used for damp-heat diarrhea, jaundice, leukorrhagia, heat stranguria, beriberi, flaccidity { exorcising exorcism }, bone steaming and internal heat, night sweat, spermatorrhea, pyogenic infections, eczema and pruritus, and the phellodendron salt has the effects of nourishing yin and reducing fire, is used for yin deficiency and fire excess, night sweat and bone steaming, and is effective on staphylococcus aureus, pneumococcus, diphtheria bacillus, viridis streptococcus, dysentery bacillus (except Song Neission) and the like; the content range of the borneol is 7mg/ml, the borneol is used for treating sore and ulcer swelling and pain, can not heal after ulceration, also has the functions of clearing away heat and toxic materials, preventing corrosion and promoting granulation, and can also promote the absorption of medicaments.
Furthermore, the total matrines content range of the sophora flavescens is 90mg/ml, the sophora flavescens is used for treating heat dysentery, hematochezia, jaundice anuresis, leucorrhea with reddish discharge, vulva swelling and pruritus vulvae, eczema, skin pruritus, mange and leprosy, trichomonas vaginitis is externally treated, the external medicine has the functions of activating blood and stopping bleeding, clearing away the lung-heat and relieving cough, resisting anoxia, fatigue and cold, can improve the strength and flexibility of organisms, can quickly recover fatigue, regulate the immune system, has a bidirectional regulation function on brain and organ functions, and has the functions of promoting urination, relieving asthma, hypnosis, resisting arrhythmia and the like, the content range of the catechu is 5mg/ml, and the catechu is used for treating traumatic injury pain, traumatic hemorrhage, hematemesis and clearing away the lung-heat, sores and abscess are not healed, eczema, lung heat and cough, and has the effects of activating blood and relieving pain, stopping bleeding and promoting granulation, astringing dampness and eliminating phlegm.
It is worth pointing out that the content range of the glycerol is 125mg/ml, and the glycerol can moisten vaginal mucosa, promote drug permeation and play roles in moisturizing, thickening and lubricating.
Example 3
The invention provides a gynecological gel which comprises the following raw materials: 10 parts of glycerin, 2.7 parts of gel, 1.95 parts of heat clearing agent and 7.3 parts of blood activating agent, and the balance of water.
In this embodiment, the heat-clearing agent comprises lithospermum, phellodendron amurense and borneol as raw materials, and the preparation method of the heat-clearing agent comprises the following steps:
s1.1, grinding borneol, mixing phellodendron and lithospermum and adding water to decoct for three times, decocting the phellodendron and the lithospermum in water for three times, decocting for 2 hours for the first time, and decocting for 1 hour for the second time and the third time respectively to obtain decoction;
s1.2, filtering to obtain a liquid, concentrating the filtrate to obtain a clear paste with the relative density of 1.10, adding ethanol, and concentrating to obtain a thick paste with the relative density of 1.36;
s1.3, drying the thick paste, crushing into fine powder, adding glycerol into the fine powder, mixing, heating and melting, and keeping the temperature at 40 +/-2 ℃;
s1.4, adding the phellodendron and lithospermum synthesized fine powder, and stirring and cooling.
Further, the blood activating agent comprises total matrines and catechu, and the preparation method of the blood activating agent comprises the following steps:
s2.1, smashing catechu into fine powder to form infant tea powder;
s2.2, putting the total matrine into a beaker, adding 600ml of water, heating until the total matrine is completely dissolved, and adjusting the pH value to 4-5 by using dilute hydrochloric acid to form a total matrine solution;
s2.3, pouring the catechu powder into the total matrine solution, and fully stirring and mixing.
Specifically, the gel is sodium carboxymethyl cellulose, which is a carboxymethylated derivative of cellulose and is the most main ionic cellulose gum, and the sodium carboxymethyl cellulose is white fibrous or granular powder, is odorless, tasteless and hygroscopic, and is easily dispersed in water to form a transparent colloidal solution, and the preparation method of the gel comprises the following steps:
s3.1, placing sodium carboxymethylcellulose in a beaker, adding glycerol, and fully and uniformly mixing;
s3.2, standing for about 30min, slowly adding the total matrine solution while stirring to be uniform;
and S3.3, standing for 1-2 hours, adding water to the full amount, uniformly stirring, placing into an infusion bottle, sealing, and sterilizing for 30min at 100 ℃ by circulating steam.
In addition, the content range of the sodium carboxymethyl cellulose is 27mg/ml, the viscosity of the gel can be adjusted along with climate change, and the situation that the sodium carboxymethyl cellulose is too high or too low and is not beneficial to patients to use is avoided.
In addition, the content range of the lithospermum is 7.5mg/ml, the lithospermum has the functions of clearing heat and promoting diuresis, some common eczemas in life and damp-heat in liver and gallbladder and the like, can be used as a treatment method, can also inhibit staphylococcus aureus and bacillus prodigiosus, treat vulvar eczema, vaginitis and cervicitis, increase of vaginal discharge of female urogenital fistula patients due to frequent urine leakage and eczema, erosion and ulcer of pudendum and various reasons, can take effect after being coated with the lithospermum oil for about 3-5 days, is used for vaginitis, and can be treated well in 4-6 days after being coated generally, and the recurrence rate is low; the content range of the phellodendron is 7.5mg/ml, the phellodendron has the effects of clearing heat and drying dampness, purging fire and removing steam, detoxifying and curing sores, is used for damp-heat diarrhea and dysentery, jaundice, leucorrhea, heat stranguria, beriberi, flaccidity { dagger }, bone steaming and internal heat, night sweat, spermatorrhea, pyogenic infections, eczema and pruritus, and the salted phellodendron is used for nourishing yin and reducing fire, is used for yin deficiency and fire excess, is used for night sweat and bone steaming, and is effective on staphylococcus aureus, pneumococcus, corynebacterium diphtheriae, viridans streptococcus, dysentery bacillus (except Song Neisseria) and the like; the content range of the borneol is 4.5mg/ml, the borneol is used for sore and ulcer swelling and pain, unhealing after ulceration, has the functions of clearing away heat and toxic materials, preventing corrosion and promoting granulation, and can also promote the absorption of medicaments, and because the borneol belongs to a natural transdermal enhancer, the borneol can promote the absorption and utilization of external cortical hormone and analgesic medicaments.
Furthermore, the total matrines content range of the sophora flavescens is 70mg/ml, the sophora flavescens is used for treating heat dysentery, hematochezia, jaundice anuresis, leucorrhea with reddish discharge, vulva swelling and pruritus vulvae, eczema, skin pruritus, mange and leprosy, trichomonas vaginitis is externally treated, the external medicine has the functions of activating blood and stopping bleeding, clearing away the lung-heat and relieving cough, resisting anoxia, fatigue and cold, can improve the strength and flexibility of organisms, can quickly recover fatigue, regulate the immune system, has a bidirectional regulation function on brain and organ functions, has the functions of promoting urination, relieving asthma, hypnosis, resisting arrhythmia and the like, the content range of the catechu is 3mg/ml, and the catechu is used for treating traumatic injury pain, traumatic hemorrhage, hematemesis and clearing away the lung-heat, sores and bleeding are not healed, eczema and lung heat cough, and has the effects of activating blood and relieving pain, stopping bleeding and promoting granulation, astringing dampness and eliminating phlegm.
It is worth to say that the content range of the glycerol is 100mg/ml, and the glycerol can moisten vaginal mucosa, promote drug permeation and play roles in moisturizing, thickening and lubricating.
Comparative example 1
The invention provides a gynecological gel which comprises the following raw materials: 7.5 to 12.5 portions of glycerin, 2.5 to 3.0 portions of gel, 5.1 to 9.5 portions of blood activating agent, and the rest is water.
As a further improvement of the technical scheme, the blood activating agent comprises total matrines and catechu, and the preparation method of the blood activating agent comprises the following steps:
s2.1, smashing catechu into fine powder to form infant tea powder;
s2.2, putting the total matrine into a beaker, adding 600ml of water, heating until the total matrine is completely dissolved, and adjusting the pH value to 4-5 by using dilute hydrochloric acid to form a total matrine solution;
s2.3, pouring the catechu powder into the total matrine solution, and fully stirring and mixing.
As a further improvement of the technical scheme, the gel agent is sodium carboxymethyl cellulose which is a carboxymethylated derivative of cellulose and is the most main ionic cellulose gum, the sodium carboxymethyl cellulose is white fibrous or granular powder, is odorless, tasteless and hygroscopic, and is easy to disperse in water to form a transparent colloidal solution, and the preparation method of the gel agent comprises the following steps:
s3.1, placing sodium carboxymethylcellulose in a beaker, adding glycerol, and fully and uniformly mixing;
s3.2, standing for about 30min, slowly adding the total matrine solution while stirring to be uniform;
and S3.3, standing for 1-2 hours, adding water to the full amount, uniformly stirring, placing into an infusion bottle, sealing, and sterilizing for 30min at 100 ℃ by circulating steam.
As a further improvement of the technical scheme, the content range of the sodium carboxymethylcellulose is 25-30mg/ml, the viscosity of the gel can be adjusted along with climate change, and the situation that the sodium carboxymethylcellulose is too high or too low and is not beneficial to patients to use is avoided.
As a further improvement of the technical proposal, the content range of the total matrines of the lightyellow sophora root is 50-90mg/ml, the lightyellow sophora root is used for treating heat dysentery, hematochezia, jaundice anuresis, leucorrhea with reddish discharge, vulvar swelling and pruritus vulvae, eczema, skin pruritus, scabies, tinea and leprosy, has the functions of promoting blood circulation and stopping bleeding, clearing away the lung-heat and stopping cough, resisting anoxia, fatigue and cold, can improve the strength and flexibility of the organism, can quickly recover fatigue, adjust the immune system, has the bidirectional adjusting function to the functions of the brain and organs, also has the functions of promoting urination, relieving asthma, hypnotizing, resisting arrhythmia and the like, the content range of the catechu is 1-5mg/ml, the catechu is used for treating traumatic injury, traumatic hemorrhage, hematemesis and epistaxis, unhealing sores, eczema, moist sores and cough, has the functions of promoting blood circulation and relieving pain, promoting granulation and stopping bleeding, astringing dampness and healing, clearing lung-heat and eliminating phlegm.
As a further improvement of the technical scheme, the content range of the glycerol is 75-125mg/ml, and the glycerol can moisten the mucosa of the vagina, promote the penetration of the medicament and play roles in preserving moisture, thickening and lubricating.
Comparative example 2
The invention provides a gynecological gel which comprises the following raw materials: 7.5 to 12.5 portions of glycerin, 2.5 to 3.0 portions of gel, 5.1 to 9.5 portions of blood activating agent, and the rest is water.
As a further improvement of the technical scheme, the blood activating agent comprises total matrines, and the preparation method of the blood activating agent comprises the following steps:
s1.1, putting the total matrine into a beaker, adding 600ml of water, heating until the total matrine is completely dissolved, and adjusting the pH value to 4-5 by using dilute hydrochloric acid to form a total matrine solution.
As a further improvement of the technical scheme, the gel agent is sodium carboxymethyl cellulose which is a carboxymethylated derivative of cellulose and is the most main ionic cellulose gum, the sodium carboxymethyl cellulose is white fibrous or granular powder, is odorless, tasteless and hygroscopic, and is easy to disperse in water to form a transparent colloidal solution, and the preparation method of the gel agent comprises the following steps:
s2.1, placing sodium carboxymethylcellulose in a beaker, adding glycerol, and fully and uniformly mixing;
s2.2, standing for about 30min, slowly adding the total matrine solution while stirring to be uniform;
and S2.3, standing for 1-2 hours, adding water to the full amount, uniformly stirring, placing into an infusion bottle, sealing, and sterilizing for 30min at 100 ℃ by circulating steam.
As a further improvement of the technical scheme, the content range of the sodium carboxymethylcellulose is 25-30mg/ml, the viscosity of the gel can be adjusted along with climate change, and the situation that the sodium carboxymethylcellulose is too high or too low and is not beneficial to patients to use is avoided.
As a further improvement of the technical scheme, the content range of the total matrines is 50-90mg/ml, and the sophora flavescens is used for treating heat dysentery, hematochezia, jaundice anuresis, leucorrhea with reddish discharge, vulva swelling and pruritus vulvae, eczema, skin pruritus, scabies, tinea and leprosy, externally treating trichomonas vaginitis, has the effects of activating blood, stopping bleeding, clearing away the lung-heat, relieving cough, resisting anoxia, resisting fatigue and cold, can improve the strength and flexibility of an organism, can quickly recover fatigue, regulates an immune system, has a bidirectional regulation function on brain and organ functions, and also has the effects of promoting urination, relieving asthma, hypnotizing, resisting arrhythmia and the like.
As a further improvement of the technical scheme, the content range of the glycerol is 75-125mg/ml, and the glycerol can moisten the mucosa of the vagina, promote the penetration of the medicament and play roles in preserving moisture, thickening and lubricating.
Product performance comparison table
Heat clearing effect Effect of promoting blood circulation Bacteriostatic effect
Example 1 Good effect Good effect Good effect
Example 2 High strength High strength High strength
Example 3 High strength High strength Extremely strong
Comparative example 1 Difference (D) Good effect Difference (D)
Comparative example 2 Difference (D) Difference (D) Difference (D)
According to the table, the gynecological gel obtained by the invention is superior to the gynecological gel sold on the general market in heat clearing and blood activating effects, and the heat clearing agent and the blood activating agent are added into the gynecological gel, so that the inhibiting effect of the gynecological gel on germs can be obviously improved.
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, and the above embodiments and descriptions are only preferred examples of the present invention and are not intended to limit the present invention, and that various changes and modifications may be made without departing from the spirit and scope of the present invention, which fall within the scope of the claimed invention. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims (8)

1. The gynecological gel comprises the following raw materials: 7.5 to 12.5 portions of glycerin, 2.5 to 3.0 portions of gel, 1.0 to 2.9 portions of heat clearing agent, 5.1 to 9.5 portions of blood activating agent, and the rest is water.
2. The gynecological gel according to claim 1, characterized in that: the heat clearing agent comprises raw materials of lithospermum, phellodendron and borneol, and the preparation method of the heat clearing agent comprises the following steps:
s1.1, grinding borneol, mixing phellodendron and lithospermum, adding water, decocting for three times, and combining the decoctions to obtain a liquid;
s1.2, filtering to obtain a liquid, concentrating the filtrate to obtain a clear paste with the relative density of 1.10, adding ethanol, and concentrating to obtain a thick paste with the relative density of 1.36;
s1.3, drying the thick paste, crushing into fine powder, adding glycerol into the fine powder, mixing, and heating to melt;
s1.4, adding the phellodendron and lithospermum synthesized fine powder, and stirring and cooling.
3. The gynecological gel according to claim 1, characterized in that: the blood activating agent comprises total matrines and catechu, and the preparation method of the blood activating agent comprises the following steps:
s2.1, smashing catechu into fine powder to form infant tea powder;
s2.2, putting the total matrine into a beaker, adding 600ml of water, heating until the total matrine is completely dissolved, and adjusting the pH value to 4-5 by using dilute hydrochloric acid to form a total matrine solution;
s2.3, pouring the catechu powder into the total matrine solution, and fully stirring and mixing.
4. The gynecological gel according to claim 1, characterized in that: the gel is sodium carboxymethyl cellulose, and the preparation method of the gel comprises the following steps:
s3.1, placing sodium carboxymethylcellulose in a beaker, adding glycerol, and fully and uniformly mixing;
s3.2, standing for about 30min, slowly adding the total matrine solution while stirring to be uniform;
and S3.3, standing for 1-2 hours, adding water to the full amount, uniformly stirring, placing into an infusion bottle, sealing, and sterilizing for 30min at 100 ℃ by circulating steam.
5. The gynecological gel according to claim 2, characterized in that: the content range of the lithospermum is 5-10mg/ml, the content range of the phellodendron is 3-12mg/ml, and the content range of the borneol is 2-7 mg/ml.
6. The gynecological gel according to claim 3, characterized in that: the content range of the total matrines is 50-90mg/ml, and the content range of the catechu is 1-5 mg/ml.
7. The gynecological gel according to claim 4, characterized in that: the content of the glycerol is in the range of 75-125 mg/ml.
8. The gynecological gel according to claim 4, characterized in that: the content range of the sodium carboxymethyl cellulose is 25-30 mg/ml.
CN202010781251.3A 2020-08-06 2020-08-06 Gynecological gel Pending CN112156138A (en)

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Application publication date: 20210101