CN108403721B - Water stone haemorrhoids ointment and preparation method thereof - Google Patents
Water stone haemorrhoids ointment and preparation method thereof Download PDFInfo
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- CN108403721B CN108403721B CN201810366756.6A CN201810366756A CN108403721B CN 108403721 B CN108403721 B CN 108403721B CN 201810366756 A CN201810366756 A CN 201810366756A CN 108403721 B CN108403721 B CN 108403721B
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/413—Gall bladder; Bile
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Vascular Medicine (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Abstract
A water stone hemorrhoids ointment and a preparation method thereof belong to the field of hemorrhoids treatment medicines. The paste is prepared from 2400-2600 parts of fresh pig bile, 28-32 parts of calcite and 18-22 parts of calamine by weight, the weighed fresh pig bile is poured into an earthen pot, the earthen pot is placed on a stove and is boiled with fire, when the color of the fresh pig bile is brown, the mixed medicinal powder obtained in the step (2) is quickly poured into the earthen pot, boiling is continued under stirring, when the color of the fresh pig bile is black and bubbles, a stirring rod is used for dipping the bile and dripping the bile into cold water, when the bile does not disperse in the water and is coagulated into a whole, the boiling is immediately stopped, and the earthen pot is taken off from the fire to prepare the water-stone hemorrhoid paste. The invention has mild action, no toxic or side effect, direct effect on focus of infection by the administration of the affected part, low cost, quick effect and high cure rate.
Description
Technical Field
The invention belongs to the field of medicaments for treating hemorrhoids; in particular to a water stone hemorrhoids ointment and a preparation method thereof.
Background
Hemorrhoid is a chronic disease of one or more soft vein masses formed by expansion and flexion of venous plexus at the lower end of anorectum and under the skin of anal canal, and the vein masses are commonly called hemorrhoids and are divided into three types, namely internal hemorrhoid, external hemorrhoid and mixed hemorrhoid according to the generation parts. The traditional Chinese medicine considers that hemorrhoids are mostly affected by turbid qi and blood stasis flowing into anus caused by damp-heat accumulation, sedentary, long standing, spicy food or labor force in parturition, constipation and the like. Internal hemorrhoids are characterized by hemafecia as the main clinical characteristic, while external hemorrhoids are characterized by abdominal pain and foreign body sensation. In the process of suffering from hemorrhoids, the blood is congested and injected into the anus to cause hematochezia and thrombus due to dry stool, anal fissure abrasion, forced defecation or weight bearing and air intake. Bleeding often occurs in hemorrhoids, blood loss gradually occurs, blood deficiency can be caused, swelling and pain can occur locally due to rupture of hemorrhoid mucosa and infection of damp-heat toxin, hemorrhoid gradually grows to block anus, and the hemorrhoid can be taken out of anus during defecation. For patients with chronic hemorrhoids, the old and weak patients can not lift the hemorrhoids due to anal relaxation and qi deficiency, and the hemorrhoids especially drop out of solution and are not easy to recover by themselves, which seriously affects the work and life of the patients.
Disclosure of Invention
The invention aims to provide a water stone hemorrhoids ointment and a preparation method thereof.
The invention is realized by the following technical scheme:
the calcite hemorrhoid ointment is prepared from 2400-2600 parts by weight of fresh pig bile, 28-32 parts by weight of calcite and 18-22 parts by weight of calamine.
The water stone hemorrhoid ointment of the invention comprises 2500 parts of fresh pig bile, 30 parts of gypsum rubrum and 20 parts of calamine.
According to the water stone hemorrhoid ointment, the weight parts of fresh pig bile in the water stone hemorrhoid ointment are 2400 parts, the weight parts of gypsum rubrum are 28 parts, and the weight parts of calamine are 18 parts.
The weight parts of fresh pig bile in the aqueous stone hemorrhoid ointment are 2600 parts, the weight parts of gypsum rubrum are 32 parts, and the weight parts of calamine are 22 parts.
According to the gypsum hemorrhoid ointment, the gypsum rubrum is gypsum rubrum powder, and the particle size of the gypsum rubrum powder is 100-200 meshes.
The calcite hemorrhoid ointment provided by the invention is prepared from calamine powder, and the particle size of the calamine powder is 100-200 meshes.
The preparation method of the water stone hemorrhoids ointment comprises the following steps:
step 1, 2400-2600 parts of fresh pig bile, 28-32 parts of calcite and 18-22 parts of calamine are respectively weighed according to parts by weight for later use;
step 2, uniformly mixing the weighed calcite and the calamine to obtain mixed medicinal powder for later use;
step 3, pouring the weighed fresh pig bile into an earthen pot, placing the earthen pot on a stove, decocting on fire, dipping bile into cold water by using a stirring rod when the color of the fresh pig bile is brown, quickly pouring the mixed medicinal powder in the step 2 when the bile is in a state of slightly dispersing to be coagulated in the water, continuing decocting under the stirring condition, dipping the bile into the cold water by using the stirring rod when the color of the fresh pig bile is black and bubbling, stopping decocting immediately when the bile is not dispersed in the water and coagulated into a lump, and taking the earthen pot away from the fire to prepare the water stone hemorrhoid ointment;
and 4, subpackaging the gypsum hemorrhoid ointment prepared in the step 3, cooling to room temperature, and sealing for storage.
According to the preparation method of the water-stone hemorrhoid ointment, stirring conditions in the step 3 are that the stirring rotating speed is 50-100 r/min.
The preparation method of the water stone hemorrhoid ointment comprises the steps of 3, dipping the stirring rod into the bile for the first time, dripping the bile into cold water, continuously boiling the bile when the bile is scattered in the water, repeating the step of dipping the bile into the bile by using the stirring rod and dripping the bile into the cold water for observation at intervals of 1-2 minutes, and adding the medicinal powder mixed in the step 2 until the bile is slightly scattered to be coagulated in the water.
According to the invention, the fresh pig bile is a thick colored liquid with bitter taste, is bitter and cold, enters liver and gallbladder channels, is considered by traditional Chinese medicine to have the functions of dredging the upper and lower parts, inducing diuresis to alleviate edema, clearing heat and removing toxicity, and healing sore and swelling, is an excellent medicinal material and clears heat; moistening dryness; and (5) detoxifying. It can be used for treating fever, constipation, cough, asthma, conjunctival congestion, nebula, dysentery, jaundice, pharyngitis, purulent otitis media, carbuncle, cellulitis, furuncle, fistula, eczema, and tinea capitis.
The calcite hemorrhoid ointment is prepared from calcite which is an ore traditional Chinese medicinal material, is a heat-clearing and fire-purging agent, is also called as travertine, water stone and magpie, and is natural sedimentary mineral monoclinic calcium sulfate or trigonal calcium carbonate ore. Pungent, salty and cold in flavor. It enters heart, stomach and kidney meridians to clear heat and purge fire, induce resuscitation and relieve swelling. Can be used for treating fever, polydipsia, erysipelas, and scald. The Shen nong Ben Cao Jing discusses that the body heat, pathogenic qi accumulation in the abdomen, and fire, restlessness and water retention in the skin. The book Jing Jie Yuan (the meeting Source of the book) discusses that the cold water stone treats the upper-aspect drugs of heart and kidney heat accumulation, and the book Jing treats abdominal accumulation and salty flavor can soften hardness; when the body heat is hot, salty can lower fire if it is burnt. In Feng Chi Tang from jin Kui, Zi Xue from He Ji Ju Fang, it is indicated for excess pathogenic heat.
In the water stone hemorrhoids ointment, calamine is carbonate mineral Calcite family calamine which mainly contains zinc carbonate. After picking, cleaning, drying in the sun and removing miscellaneous stones. The product is a block-shaped aggregate, and is in the form of irregular block, gray white or light red. The surface is powdery, matt, uneven, porous and cellular. Light weight and easy to break. No odor, slightly astringent taste. The functional indications are as follows: detoxify, improve vision, remove nebula, astringe dampness, relieve itching, heal wound, astringe dampness, promote granulation and prevent ulcer from astringing. Can be used for treating conjunctival congestion, swelling and pain, conjunctival congestion, corneal pterygium, unhealed ulcer, dribbling pus, eczema, and skin pruritus.
According to the water-stone hemorrhoid ointment, 2500g of bile needs 28-35 fresh pig gall.
The brucite hemorrhoids ointment is prepared by compounding and decocting fresh pig bile, calcite and calamine, has good synergistic effect on treatment of hemorrhoids, can achieve curative effect in a short time, is uniformly applied to focus when in use, is applied twice a day and once in the morning and at night, and is cleaned by light saline before application. The water stone hemorrhoid ointment takes effect 10-20min after being smeared on a focus, can immediately relieve pain, and completely eliminates symptoms in 3-5 days; the water stone hemorrhoids ointment has the functions of diminishing inflammation, relieving pain, removing swelling, stopping bleeding and promoting wound repair and healing, and has obvious treatment effect on the symptoms of inflammation, swelling, bleeding and the like of hemorrhoids.
The water stone hemorrhoid ointment has mild action and no toxic or side effect, can be directly applied to affected parts to focus, and has the advantages of low cost, quick response, high cure rate and the like.
Detailed Description
The first embodiment is as follows:
the water stone hemorrhoid ointment is prepared from 2600 parts of fresh pig bile, 32 parts of cold water stone and 22 parts of calamine.
In the gypsum hemorrhoid ointment of the present embodiment, the gypsum rubrum is gypsum rubrum powder, and the particle size of the gypsum rubrum powder is 100 meshes.
In the aqueous stone hemorrhoid ointment according to the present embodiment, the calamine is calamine powder, and the particle size of the calamine powder is 100 meshes.
The one-time damaged skin irritation test is carried out by selecting 3 healthy white rabbits with the weight of 20-25kg, shearing off hairs on two sides of the spinal column of the rabbits 24 hours before the test, wiping and disinfecting the skin at a hair removal part by using 75% alcohol for about 3cm × 3 cm. days after the hair removal range is left and right, scratching a 'well' -shaped damaged wound in a skin area by using an injection needle, smearing 1g of the water stone hemorrhoid ointment on the skin at the damaged part, covering 4 layers of gauze, covering with a layer of oiled paper, fixing by using a non-irritant adhesive plaster, using equal amount of sterilized distilled water as a control for the other side of the hair-removed damaged skin, carrying out the same treatment as before, removing residual water stone hemorrhoid ointment by using distilled water after 8 hours of application, and observing the local reaction of the skin 1 hour, 24 hours and 48 hours after removing a test object.
After observation, the one-time irritation test of the aqueous stone haemorrhoids ointment to the damaged skin of the rabbit shows that the skin of the rabbit has no obvious change, and the aqueous stone haemorrhoids ointment is judged to have no irritation to the skin.
The second embodiment is as follows:
the preparation method of the water stone hemorrhoid ointment according to the specific embodiment comprises the following steps:
step 1, respectively weighing 2600 parts of fresh pig bile, 32 parts of calcite and 22 parts of calamine according to parts by weight for later use;
step 2, uniformly mixing the weighed calcite and the calamine to obtain mixed medicinal powder for later use;
step 3, pouring the weighed fresh pig bile into an earthen pot, placing the earthen pot on a stove, decocting with fire, when the color of the fresh pig bile is brown, quickly pouring the mixed medicinal powder obtained in the step 2, continuously decocting under the condition of stirring, when the color of the fresh pig bile is black and bubbles, dipping the bile by using a stirring rod, dripping the bile into cold water, when the bile is not dispersed in the water and is aggregated into a mass, immediately stopping decocting, and taking the earthen pot out of the fire to obtain the water-stone hemorrhoid ointment;
and 4, subpackaging the gypsum hemorrhoid ointment prepared in the step 3, cooling to room temperature, and sealing for storage.
In the method for preparing the water stone hemorrhoid ointment according to the embodiment, the stirring condition in the step 3 is the stirring rotating speed of 100 r/min.
The preparation method of the water stone hemorrhoid ointment comprises the following steps of dipping the stirring rod into the bile in step 3, dripping the bile into cold water, dispersing the bile in the water, continuously decocting the bile at an interval of 2-5 minutes, and dipping the bile into the cold water again by using the stirring rod for observation.
The third concrete implementation mode:
the brucite hemorrhoids ointment is prepared from 2500 parts by weight of fresh pig bile, 30 parts by weight of calcite and 20 parts by weight of calamine.
In the gypsum hemorrhoid ointment of the present embodiment, the gypsum rubrum is gypsum rubrum powder, and the particle size of the gypsum rubrum powder is 200 meshes.
In the hemorrhoid ointment of the present embodiment, the calamine is calamine powder, and the particle size of the calamine powder is 200 meshes.
500 patients are selected from the aqueous gypsum hemorrhoid ointment of the embodiment, the age is 18-65 years old, 150 men and 150 women are randomly divided into 3 groups, the group is the aqueous gypsum hemorrhoid ointment group, the control group 1 is a bile-gypsum rubrum control group, and the control group 2 is a bile-calamine control group. After 3 groups of patients clean and dry the focus, uniformly applying the gypsum hemorrhoid ointment, the comparison group 1 ointment and the comparison group 2 ointment on the focus respectively twice a day, once in the morning and at night, cleaning the affected part with light saline before applying, and recording the symptoms of the patients after applying for 10min, 20min, 30min, 1D, 3D and 5D, wherein the effects are obvious: no bleeding and bleeding, obviously reduced pain, obviously shortened wound healing time and complete wound healing; the method has the following advantages: bleeding and bleeding do not exist, pain is relieved, the healing time of the wound surface is shortened, and the wound surface is basically healed; and (4) invalidation: little bleeding or little bleeding, no pain relief and no obvious shortening of the healing time of the wound surface. The records are as in tables 1-6:
TABLE 110 min patient after-treatment Effect control Table
TABLE 220 min patient after-treatment Effect control Table
TABLE 330 min patient after-treatment Effect control Table
TABLE 41D comparison of post-treatment efficacy of patients
TABLE 53 post-treatment efficacy of patients
TABLE 65D comparative Table of post-treatment efficacy of patients
As can be seen from tables 1 to 6, with the adoption of the gypsum hemorrhoid ointment of the embodiment, the pain of a patient is remarkably relieved after 30min, the effective rate reaches 100%, the wound surface is remarkably and gradually improved after 1d, the complete healing rate of the wound surface reaches 93% after 5d, most of the healing rate of the wound surface reaches 100%, compared with the independent combination of bile-gypsum rubrum and the combination of bile-calamine, the ointment prepared by compounding and decocting fresh pig bile, gypsum rubrum and calamine has a good synergistic effect on the treatment of hemorrhoids, the curative effect can be achieved in a short time, the gypsum hemorrhoid ointment can take effect after being smeared on a focus for 10-20min, pain can be immediately relieved, and symptoms can be completely eliminated in 3-5 days; the water stone hemorrhoids ointment has the functions of diminishing inflammation, relieving pain, removing swelling, stopping bleeding and promoting wound repair and healing, and has obvious treatment effect on the symptoms of inflammation, swelling, bleeding and the like of hemorrhoids.
The fourth concrete implementation mode:
the brucite hemorrhoids ointment is prepared from 2400 parts by weight of fresh pig bile, 28 parts by weight of calcite and 18 parts by weight of calamine.
In the gypsum hemorrhoid ointment of the present embodiment, the gypsum rubrum is gypsum rubrum powder, and the particle size of the gypsum rubrum powder is 200 meshes.
In the hemorrhoid ointment of the present embodiment, the calamine is calamine powder, and the particle size of the calamine powder is 200 meshes.
The rhinestone hemorrhoid ointment has the advantages that pain of a patient is relieved remarkably after 30min, the effective rate reaches 100%, the wound surface is good gradually after 1d, the complete healing rate of the wound surface reaches 93% after 5d, most of the healing rate of the wound surface reaches 100%, and compared with a single bile-rhinestone combination and a bile-calamine combination, the ointment prepared by compounding and decocting fresh pig bile, calcite and calamine has a good synergistic effect on hemorrhoid treatment, can achieve a curative effect in a short time, acts 10-20min after the rhinestone hemorrhoid ointment is smeared on a focus, pain can be relieved immediately, and symptoms are completely eliminated in 3-5 days; the water stone hemorrhoids ointment has the functions of diminishing inflammation, relieving pain, removing swelling, stopping bleeding and promoting wound repair and healing, and has obvious treatment effect on the symptoms of inflammation, swelling, bleeding and the like of hemorrhoids.
The water stone hemorrhoid ointment has the advantages of mild action, no toxic or side effect, direct effect on focus of infection by administration at affected parts, low cost, quick response, high cure rate and the like.
Claims (9)
1. The water stone hemorrhoids ointment is characterized in that: the calcite hemorrhoid ointment is prepared from 2400-2600 parts by weight of fresh pig bile, 28-32 parts by weight of calcite and 18-22 parts by weight of calamine;
pouring weighed fresh pig bile into an earthen pot, placing the earthen pot on a stove, decocting on fire, when the color of the fresh pig bile is brown, dipping the bile into cold water by using a stirring rod, when the bile is in a state of slightly dispersing to be condensed in the water, quickly pouring mixed medicinal powder obtained by uniformly mixing calcite and calamine, continuously decocting under the condition of stirring, when the color of the fresh pig bile is black and bubbles, dipping the bile into the cold water by using the stirring rod, when the bile is not dispersed in the water and is condensed into a mass, immediately stopping decocting, and taking the earthen pot away from the fire to prepare the water stone hemorrhoid ointment; the gypsum hemorrhoid ointment takes effect 10-20min after being smeared on a focus, can immediately relieve pain, and completely eliminates symptoms in 3-5 days;
the fresh pig bile, calcite and calamine are compounded and decocted into paste, so that the paste has a good synergistic effect on the treatment of the hemorrhoids, the curative effect can be achieved within a short time, the calcite hemorrhoid paste is uniformly applied to the focus when in use, the focus is coated twice every day and once in the morning and at night, and the affected part is cleaned by light saline before being coated.
2. The aqueous stone hemorrhoid ointment of claim 1, characterized in that: the weight portion of fresh pig bile in the brucite hemorrhoids ointment is 2500 portions, the weight portion of calcite is 30 portions, and the weight portion of calamine is 20 portions.
3. The aqueous stone hemorrhoid ointment of claim 1, characterized in that: the weight parts of fresh pig bile in the brucite hemorrhoid ointment are 2400 parts, the weight parts of calcite are 28 parts, and the weight parts of calamine are 18 parts.
4. The aqueous stone hemorrhoid ointment of claim 1, characterized in that: the weight parts of fresh pig bile in the calcite hemorrhoid ointment are 2600 parts, the weight parts of calcite are 32 parts, and the weight parts of calamine are 22 parts.
5. The aqueous stone hemorrhoid ointment according to claim 1 or 2, characterized in that: the gypsum rubrum is gypsum rubrum powder, and the particle size of the gypsum rubrum powder is 100-200 meshes.
6. The aqueous stone hemorrhoid ointment according to claim 1 or 2, characterized in that: the calamine is calamine powder, and the grain size of the calamine powder is 100-200 meshes.
7. A method for preparing the water stone hemorrhoid ointment of claim 1, which is characterized in that: the method comprises the following steps:
step 1, 2400-2600 parts of fresh pig bile, 28-32 parts of calcite and 18-22 parts of calamine are respectively weighed according to parts by weight for later use;
step 2, uniformly mixing the weighed calcite and the calamine to obtain mixed medicinal powder for later use;
step 3, pouring the weighed fresh pig bile into an earthen pot, placing the earthen pot on a stove, decocting on fire, dipping bile into cold water by using a stirring rod when the color of the fresh pig bile is brown, quickly pouring the mixed medicinal powder in the step 2 when the bile is in a state of slightly dispersing to be coagulated in the water, continuing decocting under the stirring condition, dipping the bile into the cold water by using the stirring rod when the color of the fresh pig bile is black and bubbling, stopping decocting immediately when the bile is not dispersed in the water and coagulated into a lump, and taking the earthen pot away from the fire to prepare the water stone hemorrhoid ointment;
and 4, subpackaging the gypsum hemorrhoid ointment prepared in the step 3, cooling to room temperature, and sealing for storage.
8. The method for preparing the water stone hemorrhoid ointment according to claim 7, wherein: in the step 3, the stirring condition is that the stirring speed is 50-100 r/min.
9. The method for preparing the water stone hemorrhoid ointment according to claim 7, wherein: and 3, dipping the bile into the cold water by using the stirring rod for the first time, dispersing the bile in the water, continuously decocting the bile, and repeatedly dipping the bile into the cold water by using the stirring rod after 1-2 minutes to observe.
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