CN115300562A - Granulation promoting ointment for treating diabetic foot and preparation method thereof - Google Patents
Granulation promoting ointment for treating diabetic foot and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention belongs to the field of diabetic foot treatment, and particularly relates to a granulation promoting ointment for treating diabetic foot and a preparation method thereof, wherein the granulation promoting ointment is prepared from the following raw materials in parts by weight: 100-130 parts of cuttlebone, 30-50 parts of tortoise shell, 30-50 parts of ground beetle, 50-70 parts of radix rehmanniae recen, 50-70 parts of angelica, 80-100 parts of gypsum, 80-100 parts of calamine, 250-350 parts of beeswax and 1500-2500 parts of sesame oil. The invention has the advantages of quick curative effect, good antibacterial effect, good curative effect and no irritation and pain when being applied.
Description
Technical Field
The invention belongs to the field of treatment of diabetic feet, and particularly relates to a granulation promoting ointment for treating diabetic feet and a preparation method thereof.
Background
The whole life cycle of the diabetic foot patient is prolonged, the treatment difficulty is large, the cost burden is heavy, the prognosis is poor, the disability rate is high, the method is one of the important reasons for disability and death of the diabetic foot patient, and the method is also a public health problem which causes remarkable social problems.
The diabetic foot is easy to have a wound and the wound is delayed and not healed, the important reason is that peripheral neuropathy is divided into motor neuropathy, sensory neuropathy and autonomic neuropathy, the motor neuropathy can cause foot deformity such as claw-shaped toes and hammer-shaped toes, the sensory neuropathy can cause the loss of protective sensation such as pain, temperature and touch of a patient to easily cause trauma, the autonomic neuropathy is easy to ignore, the dysfunction of visceral plant nerve can also cause the reduction of secretion of sebaceous glands and sweat glands, so that skin dryness, desquamation and rhagadia occur, the possibility of aggravation or death of local ulcer, inflammation propagation and protraction and the like is caused under the multiple actions of skin barrier function reduction, the wound healing and the like of a diabetic foot patient, and the like, even the amputation or death of limbs is caused, and the like, the existing granulation promoting ointment is prepared by angelica, lithospermum, beeswax and sesame oil, the wound is applied to treat the diabetic foot slowly after being applied, the wound is not healed for a long time, the albumin and the wound even has poor bacteriostatic effect, the septic shock occurs in the existing wound healing process, and the septic shock is further required to be improved.
Disclosure of Invention
The invention aims to provide a tissue regeneration promoting paste for treating diabetic foot, which has the advantages of quick curative effect, good antibacterial effect, good curative effect, no irritation and pain after being applied and applied, and a preparation method thereof.
In order to solve the technical problems, the technical scheme adopted by the invention is as follows:
cuttlebone: the channels entering spleen and kidney channels, salty, astringent and warm in nature and taste, and mainly has the functions of astringing to stop bleeding, arresting seminal emission and leucorrhea, relieving hyperacidity and healing sore, and is used for treating stomachache, acid regurgitation, hematemesis, epistaxis, metrorrhagia, hematochezia, spermatorrhea, leucorrhea and leucorrhea; ulcer disease. It is used externally to treat wound bleeding, sore with pus.
Tortoise shell: the traditional Chinese medicine composition has salty and sweet taste and slightly cold nature, enters liver, kidney and heart channels, has the effects of nourishing yin and suppressing hyperactive yang, tonifying kidney and strengthening bone, nourishing blood and tonifying heart, and strengthening channels and stopping metrorrhagia, and is mainly used for treating yin deficiency and hectic fever, bone steaming and night sweat, dizziness, asthenic wind and internal movement, flaccidity of bones and muscles, heart deficiency and amnesia, and metrorrhagia and metrostaxis.
And (3) Eupolyphaga sinensis Walker: nature, taste, salty, cold; has little toxicity, enters liver meridian, has the functions of removing blood stasis and reuniting bones and muscles, and is mainly used for treating fracture of bones and muscles, amenorrhea due to blood stasis and abdominal mass.
Dried rehmannia root: nature and taste, fresh rehmannia root, sweet, bitter and cold, meridian tropism: it has effects of nourishing yin, invigorating kidney, nourishing blood, replenishing blood, and cooling blood. .
Chinese angelica root: sweet, pungent and warm, entering meridians, entering liver, heart and spleen meridians, and having the function of enriching blood; promoting blood circulation; regulating menstruation and relieving pain; moistening dryness and smoothing intestine, mainly treating blood deficiency syndrome; menoxenia; amenorrhea; dysmenorrhea; the accumulation of symptoms; (ii) metrorrhagia and metrostaxis; abdominal pain due to deficiency-cold; flaccidity and paralysis; numbness of the skin; intestinal dryness and difficult defecation; severe dysentery with diarrhea; carbuncle, cellulitis, sore and ulcer; injury from falling.
Raw gypsum: it enters lung and stomach meridians, and is sweet, pungent and cold in nature and flavor. Has the functions of clearing heat and purging fire, relieving restlessness and quenching thirst, and is mainly used for treating exogenous febrile disease, hyperpyrexia and polydipsia, lung heat and cough with dyspnea, excessive stomach fire, headache and toothache.
Calamine: the medicine has sweet taste, mild nature, meridian tropism, liver and spleen meridians entering, and functions of detumescence and granulation promotion, gypsum heat clearing and fire purging, rehmannia root for dispelling blood arthralgia, detoxification, eyesight improvement and nebula removal, dampness astringing and itching relieving and sore healing, and is mainly used for treating conjunctival congestion, swelling and pain, eyelid chord red rot, nebula covering eyes, pterygium climbing eyes, unhealed ulcer, dripping pus and sore itching.
Sesame oil: the properties and flavor of the herbs enter meridians, are sweet and cool, and have the functions of moistening dryness, relaxing bowels, detoxifying and promoting tissue regeneration. It can be used for treating constipation due to intestinal dryness, ascariasis, abdominal pain due to dyspepsia, sore, ulcer, scabies, tinea, and chapped skin.
The invention uses cuttlebone as monarch drug, calamine as ministerial drug, can remove the necrotic tissue and promote granulation and detoxify and astringe, angelica and ground beetle as adjuvant drug, beeswax is used for shaping, and provides moist healing environment for the wound surface, and the invention has the functions of protecting the wound surface, stopping bleeding, resisting inflammation and easing pain, and can promote the growth of tissue cells; calamine mainly contains zinc carbonate, and has effects of astringing wound and absorbing wound secretion; gypsum Fibrosum can act on amino acids of pathogenic bacteria to inhibit its reproduction, and can be used for treating unhealed ulcer; rehmannia root, radix rehmanniae is effective in promoting blood circulation. The medicines are used together to play the roles of inhibiting bacteria and killing bacteria, removing necrotic tissue and promoting granulation, detoxifying and astringing, promote wound healing, and promote tissue regeneration and repair. The invention has the advantages of lubrication, no stimulation, creation of a wet environment, contribution to local application, little side effect, good bacteriostatic effect, heat preservation, moisture preservation, absorption of seepage, infection resistance, pain relief, healing promotion, reasonable price, reduction of dressing change times, easy cleaning and reduction of workload.
Drawings
FIGS. 1-5 are graphs comparing the therapeutic effect of clinical treatment with the case history 1;
FIGS. 6-9 are graphs comparing the therapeutic effect of clinical treatment with the case history 2;
FIGS. 10-14 are graphs comparing the therapeutic effect of clinical treatment with the case history 3.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and do not limit the invention.
Example 1:
a granulation promoting ointment for treating diabetic foot comprises the following raw materials in parts by weight: 100 parts of cuttlebone, 30 parts of tortoise shell, 30 parts of ground beetle, 50 parts of radix rehmanniae recen, 50 parts of angelica, 80 parts of gypsum, 80 parts of calamine, 250 parts of beeswax and 1500 parts of sesame oil.
The preparation method of the granulation promoting ointment for treating diabetic foot comprises the following steps of (1) respectively grinding gypsum and calamine into fine powder, removing impurities from angelica sinensis, ground beetle, radix rehmanniae and tortoise shell, cleaning, and feeding decoction pieces; (2) Heating oleum Sesami to 200 deg.C, refining for 1h, sequentially adding carapax et Plastrum Testudinis, radix Angelicae sinensis, radix rehmanniae, and Eupolyphaga Seu Steleophaga, frying, removing residue, filtering to obtain medicinal oil; (3) Heating the filtered medicinal oil to 200 deg.C, sequentially adding Gypsum Fibrosum and Calamina, and heating for 10min to obtain mixed medicinal oil. (4) Heating and melting beeswax, filtering impurities, mixing with the medicinal oil mixed in the step (2), cooling to 70 ℃, adding cuttlebone, and stirring to obtain a paste to obtain a finished product. The fine powder after grinding in the step (1) is 100 meshes.
The using method comprises the following steps: (1) wound surface preparation: necrotic tissue at the base of wound surface (bleeding) is removed as far as possible, and is disinfected by iodophor and the like, and finally, the ointment is washed clean by normal saline to ensure the ointment to be fully absorbed. (2) ointment preparation: the absorbent cotton with the area equivalent to the area of the wound surface is selected, the ointment is evenly spread on the absorbent cotton by a tongue depressor, is pasted on the wound surface, and is fixed by gauze or bandage and the like. (3) dressing change frequency: changing the medicine every 2-3 days. If the wound surface is shallow and has chap or desquamation, the ointment is applied on the wound surface uniformly for 2-3 times per day without dressing.
Example 2:
a granulation promoting ointment for treating diabetic foot comprises the following raw materials in parts by weight: 130 parts of cuttlebone, 50 parts of tortoise shell, 50 parts of ground beetle, 70 parts of radix rehmanniae recen, 70 parts of angelica, 100 parts of gypsum, 100 parts of calamine, 350 parts of beewax and 2500 parts of sesame oil.
The preparation method of the granulation promoting ointment for treating diabetic foot comprises the following steps of (1) respectively grinding gypsum and calamine into fine powder, removing impurities from angelica sinensis, ground beetle, radix rehmanniae and tortoise shell, cleaning, and feeding decoction pieces; (2) Heating oleum Sesami to 300 deg.C, refining for 2 hr, sequentially adding carapax et Plastrum Testudinis, radix Angelicae sinensis, radix rehmanniae, and Eupolyphaga Seu Steleophaga, frying, removing residue, filtering to obtain medicinal oil; (3) Heating the filtered medicinal oil to 300 deg.C, sequentially adding Gypsum Fibrosum and Calamina, and heating for 20min to obtain mixed medicinal oil. (4) Heating and melting beeswax, filtering impurities, mixing with the medicinal oil mixed in the step (2), cooling to 90 ℃, adding cuttlebone, and stirring to obtain a paste to obtain a finished product. The fine powder after grinding in the step (1) is 200 meshes.
Example 3:
a granulation promoting ointment for treating diabetic foot comprises the following raw materials in parts by weight: 120 parts of cuttlebone, 45 parts of tortoise shell, 45 parts of ground beetle, 60 parts of radix rehmanniae recen, 60 parts of angelica, 90 parts of gypsum, 90 parts of calamine, 300 parts of beeswax and 2000 parts of sesame oil.
The preparation method of the muscle regeneration promoting ointment for treating diabetic foot comprises the following steps of (1) respectively grinding gypsum and calamine into fine powder, removing impurities from angelica sinensis, ground beetle, radix rehmanniae and tortoise shell, cleaning, and feeding decoction pieces; (2) Heating oleum Sesami to 250 deg.C, refining for 1.5h, sequentially adding carapax et Plastrum Testudinis, radix Angelicae sinensis, radix rehmanniae, and Eupolyphaga Seu Steleophaga, frying, removing residue, filtering to obtain medicinal oil; (3) And continuously heating the filtered medicinal oil to 250 ℃, sequentially adding gypsum and calamine, and heating for 15min to obtain the mixed medicinal oil. (4) Heating and melting beeswax, filtering impurities, mixing the beeswax with the medicinal oil mixed in the step (2), cooling to 80 ℃, adding cuttlebone, and stirring into paste to obtain a finished product. The fine powder after grinding in the step (1) is 150 meshes.
1, medical record:
name li chi, gender: male, age: age 36, case number: department: vascular surgery center two disease areas; a chief complaint: the skin necrosis of the left foot is broken for more than two months, and the left foot is admitted to the hospital for 2 weeks in 2020, 10 months and 23 days. And others: the hospital transfers in and amputates. And (3) diagnosis: type 1 diabetes mellitus foot disease, type 1 diabetes mellitus nephropathy IV, hypoproteinemia, anemia.
The wound surface condition and treatment comprises the following steps:
the left foot had extensive swelling and pain, with two 2 x 3cm ulcerations at the medial malleolus of the left foot, and pterygium proliferation, basal redness and purulent exudation. Medial left forefoot 1 x 1cm ulcer with purulent exudation, necrosis of basal tissue, marked yellow rot, and multiple lesions on medial left plantar aspect (fig. 1). After the patient is admitted, the treatment of infection resistance, blood sugar control, debridement, dressing change and the like is performed, the wound surface is slowly developed (figure 2), partial opening drainage is performed, the dressing change is performed by applying the granulation promoting ointment (formula in example 1) in 2 months and 11 days (figure 3), the wound surface is obviously improved in 2 months and 15 days (figure 4), the yellow rot tissues in the basal wound cavity are removed, and the dressing change is continued. The patient healed at the wound surface at 3 months and 1 day (fig. 5). When dressing change is carried out, patients do not have irritant pain, and no infection phenomenon exists after the tissue regeneration promoting ointment is used. And (3) medical record 2:
name: certain old, sex: male, age: age 64, department: vascular surgery center two disease areas; the main complaints are: the cold and numb lower limbs are half a year, and the patient is admitted to the hospital 10, 12 days and 12 days in 2020 with aggravation accompanied by rupture of the left foot for half a month. And others: ischemic gangrene, tendon exsertion, and artificial dermis is used. And (3) diagnosis: lower limb arteriosclerosis obliterans Routerford 5 grade type 2 diabetes mellitus hypertension 3 grade coronary heart disease.
The wound surface condition and treatment comprises the following steps:
after the patient is treated by the intracavitary vascular intervention and the artificial dermis and the blade cortex transplantation operation, part of wound still remains, and tendon still exposes and seeps out and is tender (+) (figure 6) after 12 months and 11 days of 2020. There was no significant progress by day 25 of 12 months (fig. 7). After 12 months and 27 days, the ointment is applied for changing the dressing, the tissue regeneration promoting ointment (the formula in the embodiment 2) is coated on the alginate dressing, the dressing is changed once every 2 to 3 days (figure 8), the obvious improvement is achieved, the dressing change lasts for 3 weeks, and the wound surface heals after 1 month and 10 days in 2021 (figure 9). When dressing change is carried out, patients do not have irritant pain, and no infection phenomenon exists after the tissue regeneration promoting ointment is used.
And (3) medical record 3:
name: certain piece, sex: male, age: age 64, case No.: department: vascular surgery center two disease areas, chief complaints: left foot ulcer is 1 year, gangrene is admitted to hospital in 2021 year, 10 month and 25 day. And others: sepsis was transferred to my hospital due to foot infections. And (3) diagnosis: foot gangrene caused by type 2 diabetes, diabetic peripheral vasculopathy, neuropathy, retinopathy, diabetic nephropathy, lower limb arteriosclerosis obliterans, coronary heart disease, hyperlipidemia, cerebral ischemia, emphysema, gallstone and prostatic hyperplasia.
The wound surface condition and treatment comprises the following steps:
the wound surface remained after the intraluminal vascular intervention and medium thickness skin graft (26/10/2021, fig. 10). The ointment is applied for changing the dressing, the tissue regeneration promoting ointment (the formula in the embodiment 3) is coated on the alginate dressing, the dressing is changed once every 2 to 3 days, fresh granulation is seen on the wound surface in 11 months and 10 days (figure 11), the wound surface in 12 months and 2 days is obviously reduced (figure 12), only the linear wound surface is seen on the wound surface in 12 months and 10 days (figure 13), and the wound surface in 12 months and 23 days is healed (figure 14). When dressing change is carried out, patients do not have irritation and pain, and no infection phenomenon exists after the tissue regeneration promoting ointment is used.
The tissue regeneration promoting ointment disclosed by the invention is good in wound healing condition and quick in curative effect, and is prepared from the medical records 1-3. The medical records selected by the invention are all serious medical records, and the effect is proved to be good.
Claims (6)
1. The muscle regeneration promoting ointment for treating diabetic foot is characterized by comprising the following raw materials in parts by weight: 100-130 parts of cuttlebone, 30-50 parts of tortoise shell, 30-50 parts of ground beetle, 50-70 parts of radix rehmanniae recen, 50-70 parts of angelica, 80-100 parts of gypsum, 80-100 parts of calamine, 250-350 parts of beeswax and 1500-2500 parts of sesame oil.
2. The tissue regeneration promoting paste for treating diabetic foot according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 100 parts of cuttlebone, 30 parts of tortoise shell, 30 parts of ground beetle, 50 parts of radix rehmanniae recen, 50 parts of angelica, 80 parts of gypsum, 80 parts of calamine, 250 parts of beeswax and 1500 parts of sesame oil.
3. The tissue regeneration promoting paste for treating diabetic foot according to claim 2, which is characterized by comprising the following raw materials in parts by weight: 130 parts of cuttlebone, 50 parts of tortoise shell, 50 parts of ground beetle, 70 parts of radix rehmanniae recen, 70 parts of angelica, 100 parts of gypsum, 100 parts of calamine, 350 parts of beeswax and 2500 parts of sesame oil.
4. The tissue regeneration promoting paste for treating diabetic foot according to claim 3, which is characterized by comprising the following raw materials in parts by weight: 120 parts of cuttlebone, 45 parts of tortoise shell, 45 parts of ground beetle, 60 parts of radix rehmanniae recen, 60 parts of angelica, 90 parts of gypsum, 90 parts of calamine, 300 parts of beeswax and 2000 parts of sesame oil.
5. The method for preparing muscle-regenerating ointment for treating diabetic foot according to claim 4, wherein (1) gypsum and calamine are respectively ground into fine powder, angelica, ground beetle, radix rehmanniae and tortoise shell are cleaned, and the decoction pieces are put into the ointment; (2) Heating oleum Sesami to 200-300 deg.C, refining for 1-2h, sequentially adding carapax et Plastrum Testudinis, radix Angelicae sinensis, radix rehmanniae, and Eupolyphaga Seu Steleophaga, frying, removing residue, filtering to obtain medicinal oil, and filtering to obtain filtered medicinal oil; (3) Heating the filtered medicinal oil at 200-300 deg.C, sequentially adding Gypsum Fibrosum and Galamina, and heating for 10-20min to obtain mixed medicinal oil; (4) Heating and melting beeswax, filtering impurities, mixing with the medicinal oil mixed in the step (2), cooling to 70-90 ℃, adding cuttlebone, and stirring to obtain paste to obtain a finished product.
6. The muscle-regenerating ointment for treating diabetic foot according to claim 1, wherein the fine powder after grinding in step (1) is 100-200 mesh.
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CN105878547A (en) * | 2015-01-14 | 2016-08-24 | 天津盛兰生物科技有限公司 | Skin-aging preventing active substance composition and preparation method thereof |
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