CN104983936A - Traditional Chinese medicine ointment for treating third-stage bedsore in clinical nursing - Google Patents
Traditional Chinese medicine ointment for treating third-stage bedsore in clinical nursing Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine ointment for treating third-stage bedsore in clinical nursing. The ointment is prepared from 8 medicinal raw materials: maesa perlarius, viola hamiltoniana (fresh), rosin, bark of kwangsi garcinia, leaf of barbate mallotus, murraya exotica, herb of common yellow oxalis, and radix angelicae. With mutual collaboration and interaction of all the raw materials, the ointment has the effects of clearing heat and detoxifying, removing rotten parts and expelling pus, relieving swelling and stopping pain, eliminating necrotic tissues and promoting tissue regeneration, and restraining to eliminate marks, so as to improve microcirculation around a wound surface, increase local blood flowing, relieve inflammatory edema and local tissue ischemia and hypoxia, reduce inflammatory exudation, and promote inflammation absorption and dissipation. At the same time, the traditional Chinese medicine ointment can provide a moist environment for the wound surface, promotes migration of epithelial cells, accelerates healing of the wound surface, allows crusta not to be formed; with an oily effect, a protection film is formed on the surface layer of the wound surface, not only is the wound surface protected to be moist, but also a medicinal liquid infiltration is facilitated, newly-formed granulation cannot be damaged when the ointment is changed, epithelization of the wound surface is facilitated, and healing of the wound surface is accelerated.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to the Chinese medicinal ointment a kind of clinical care being used for the treatment of three phase decubital ulcers.
Background technology
Decubital ulcer is local organization because long-time pressurized causes blood circulation to hinder, local soft tissue ischemia, anoxia, to fester and downright bad, therefore also known as pressure ulcer (Pressure Ulcear, PU), that body local skin and subcutaneous tissue are because of long-time pressurized, poor circulation, so that ischemia and necrosis is even festered.Multiple be born in have a delicate constitution, the patient of long-term bed, be that body part organizes long-term pressurized, blood circulation generation obstacle, can not supply the nutrition needed for skin and subcutaneous tissue, so that local organization loses normal function and forms ulcer and tissue necrosis.
According to the evolution of decubital ulcer, light and heavy degree is different, and the conventional method by stages of China is divided into the fourth phase: I phase: congestion ruddy phase, even if remove oppression state, local organization still persistence is rubescent or develop into erythema; II phase: the inflammatory infiltration phase, dermal tissue is impaired, there is vesicle, tissue erosion and skin ulcer; The III phase: either shallow ulcerative stage, damaged tissues reaches below skin corium deeply, involves subcutaneous layer of fat; IV phase: downright bad ulcerative stage, full thickness skin lacks.Popularity is damaged.The damage of accompanied by tissue necrosis or muscle, tendon, joint capsule and bone.
The treatment of pressure ulcer is auxiliary complex treatment measure to take topical therapeutic, whole body therapeutic.The treatment of pressure ulcer on the basis of local reduction, thoroughly must remove slough.Think that wound surface is dry and comfortable in the past and clean the healing being conducive to pressure ulcer, think that aseptically the moistening wound surface epithelial cell that is conducive to is formed at present, promote the healing of wound granulation tissue growth and wound surface, keep pressure ulcer wound surface moistening, be conducive to granulation growth and epithelial migration and healing acceleration.
In the process for the treatment of patients with decubitus, doctor trained in Western medicine is outside process skin ulcer face, except with except antibiotic, concentrated albumin, do not have other what active drugs can with (and antibiotic, concentrated albumin can not be used for a long time), and Chinese medicine be act on very large. not only can direct effect wound surface local, the active factor of whole body all can also have been mobilized, to promote wound neovascularization, collagen fiber are formed, accelerate protein synthesis and epithelization, thus accelerate pressure ulcer healing.
Summary of the invention
The object of this invention is to provide the Chinese medicinal ointment a kind of clinical care being used for the treatment of three phase decubital ulcers; it is that raw material is made by the Chinese herbal medicine of Chinese tradition; direct effect wound surface lesion; vomica can be made to be formed drill brokenly; pus is excreted early, and forms protecting film on wound surface top layer, not only protects wound surface moistening; also help the infiltration of medicinal liquid, be conducive to granulation growth and epithelial migration and healing acceleration.
In order to realize object of the present invention, the invention provides the Chinese medicinal ointment a kind of clinical care being used for the treatment of three phase decubital ulcers, it is made up of 8 taste medicinal raw materials such as Herba Maesae Prelarii, Viola arcuata (fresh), Colophonium, Cortex Garciniae schefferi, Folium Malloti barbati, Folium Et Cacumen Murrayae, Herba Oxalidis Strictae, the Radixs Angelicae Dahuricae.
Chinese medicinal ointment of the present invention is that inventor excavates the traditional Chinese medical science and enriches clinical experience, in conjunction with modern pharmacological research, carry out that lot of experiments draws, each medicinal raw material consumption all has good therapeutic effect in following weight parts scope: Herba Maesae Prelarii 11-15 part, Viola arcuata (fresh) 15-20 part, Colophonium 13-18 part, Cortex Garciniae schefferi 15-20 part, Folium Malloti barbati 18-23 part, Folium Et Cacumen Murrayae 9-15 part, Herba Oxalidis Strictae 8-13 part, Radix Angelicae Dahuricae 4-7 part.
Be preferably: Herba Maesae Prelarii 12 parts, Viola arcuata (fresh) 15 parts, Colophonium 15 parts, Cortex Garciniae schefferi 18 parts, Folium Malloti barbati 20 parts, Folium Et Cacumen Murrayae 10 parts, Herba Oxalidis Strictae 10 parts, the Radix Angelicae Dahuricae 5 parts.
Fang Zhong, Folium Malloti barbati bitter cold, heat-clearing and toxic substances removing, dampness removing to stop itchin, cooling blood for hemostasis, for controlling the key medicine of decubital ulcer; The bitter sweet temperature of Colophonium, dispeiling pathogenic wind and removing dampness, evacuation of pus is drawn out pus by applying a plaster to the affected part, granulation promoting pain relieving, two medicine compatibility heat-clearing and toxic substances removing, changes rotten evacuation of pus power strong, and antipruritic pain relieving of holding concurrently, detumescence and promoting granulation is monarch drug.Folium Et Cacumen Murrayae mildly bitter flavor temperature, promoting flow of QI and blood, eliminating stasis to stop pain, removing toxic substances and promoting subsidence of swelling; Viola arcuata heat-clearing and toxic substances removing, dissipating blood stasis stops blooding, and principal drug assistance promoting blood circulation to remove blood stasis, removing toxic substances and promoting subsidence of swelling is ministerial drug.Cortex Garciniae schefferi heat-clearing and toxic substances removing, reducing swelling and alleviating pain; Herba Oxalidis Strictae clearing heat for detumescence, stasis-dispelling and pain-killing, helps monarch-minister drug heat-clearing and toxic substances removing, reducing swelling and alleviating pain, is adjuvant drug.Herba Maesae Prelarii removing the necrotic tissue and promoting granulation, thinks adjuvant drug.Radix Angelicae Dahuricae expelling pathogenic wind from the body surface, sensible, the detumescence and apocenosis of dehumidifying are adjuvant.The application of all medicine associating compatibilities, medicine heat-clearing and toxic substances removing can be strengthened, change rotten evacuation of pus, the effect of reducing swelling and alleviating pain, holder necrotic tissue and promoting muscle growing, convergenceization trace, to improve microcirculation around wound surface, increase regional flow, the edema that reduces inflammation and local organization ischemia, anoxia, minimizing inflammatory exudation, promote absorption and the dissipation of inflammation.Simultaneously by putrefaction-removing granulation-promoting effect, activate body endogenous debridement process, promote that wound surface slough is discharged, stimulate wound granulation tissue and surrounding epithelial tissue to grow fast, to accelerate the healing of wound surface.
In side, the pharmacological property of each taste medicinal raw material is as follows:
Herba Maesae Prelarii: [nature and flavor] are bitter; Property is put down.[return through] heart; Liver Channel.[function cures mainly] synthetism is subsided a swelling; Removing the necrotic tissue and promoting granulation.Main injury and bone fracture; Knife injury; Furuncle abscess.
Viola arcuata: [nature and flavor] pungent fiber crops; Micro-acid; Cold in nature.[function cures mainly] heat-clearing and toxic substances removing; Dissipating blood stasis stops blooding.Main sore swollen toxin; Acute mastitis; Traumatic injury; Open fracture; Traumatic hemorrhage; Snakebite.
Colophonium: [nature and flavor] are bitter; Sweet; Warm in nature.[return through] liver; Spleen channel.[function cures mainly] dispeiling pathogenic wind and removing dampness; Evacuation of pus is drawn out pus by applying a plaster to the affected part; Granulation promoting pain relieving.Main carbuncle malignant boil; Scrofula; Fistula disease; Scabies; Bald in vain; Leprosy; Arthromyodynia; Incised wound; Sprain; Women leucorrhea; Thromboangiitis obliterans." book on Chinese herbal medicine converges and says ": Colophonium, as Ru Yang section applies ointment or plaster in material, can go pus to draw out pus by applying a plaster to the affected part, and decay maiden work or the person that just bursts can use, as most in ulcer pus and blood of a specified duration, deficiency of vital energy cold in blood, meat is general and do not hold back person, and with this not only can not tissue regeneration promoting flesh, anti-increasing be festered, prolong stream and meat, muscle arteries and veins of speaking sarcastically, undescribable, user is when sifting it.
Cortex Garciniae schefferi: [nature and flavor] are bitter; Puckery; Flat.[return through] lung; Liver Channel.[function cures mainly] heat-clearing and toxic substances removing; Reducing swelling and alleviating pain.Main burn; Scald; Carbuncle sore tumefacting virus
Folium Malloti barbati: [nature and flavor] are bitter; Cold.[return through] Liver Channel.[function cures mainly] heat-clearing and toxic substances removing; Dampness removing to stop itchin; Cooling blood for hemostasis.Main decubital ulcer; Ulcer of the lower limb; Eczema; Back of the body tinea; Dermatitis rhus; Traumatic hemorrhage.
Folium Et Cacumen Murrayae: [nature and flavor] acrid in the mouth; Micro-hardship; Warm in nature.[return through] heart; Liver; Lung meridian.[function cures mainly] promoting flow of QI and blood; Eliminating stasis to stop pain; Removing toxic substances and promoting subsidence of swelling.Main gastralgia; Tumbling and swelling; Carbuncle sore; Snake bite and insect sting
Herba Oxalidis Strictae: [nature and flavor] bitter in the mouth; Cold in nature.[return through] heart; Liver Channel.[function cures mainly] clearing heat for detumescence; Stasis-dispelling and pain-killing.Main flow fire; Toxic swelling; Gonorrhea; Traumatic injury; Burn due to hot liquid or fire; Scabies.
The Radix Angelicae Dahuricae: [nature and flavor] acrid in the mouth, warm in nature.[return through] returns lung, stomach, large intestine channel.[function cures mainly] expelling pathogenic wind from the body surface, dispersing cold for relieving pain, dehumidifying are sensible, detumescence and apocenosis.Cure mainly anemofrigid cold, headache, supraorbital bone pain, toothache, eye itching lacrimation, nasal obstruction, nasal sinusitis, wet Sheng chronic diarrhea, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores.Modern study shows to improve microcirculation in human body, and promote skin metabolism, and the water soluble ingredient of the Radix Angelicae Dahuricae has vasoconstrictor effects, the Coumarins composition byak-angelicin of the Radix Angelicae Dahuricae has dilating effect to coronary vasodilator.
Another aspect of the present invention, relate to the formula of Chinese medicinal ointment substrate clinical care being used for the treatment of three phase decubital ulcers, each substrates quantity all has better effects in following weight parts scope: lanoline 5-10 part, dimethyl sulfoxine 6-10 part, vaseline 20-35 part, liquid paraffin 2-5 part, Oleum sesami 20-30 part.
Be preferably: lanoline 7 parts, dimethyl sulfoxine 8 parts, 25 parts, vaseline, liquid paraffin 3 parts, Oleum sesami 25 parts.
Also invention additionally provides the preparation method of the Chinese medicinal ointment a kind of clinical care being used for the treatment of three phase decubital ulcers, it comprises the following steps: Folium Et Cacumen Murrayae, Viola arcuata (fresh), the Radix Angelicae Dahuricae are added the ethanol extraction secondary of 75%, each 1.5-2.0 hour, collect ethanol extraction filtering residue, merge extractive liquid, concentrating under reduced pressure becomes dry extract, pulverizes for subsequent use; Herba Maesae Prelarii, Cortex Garciniae schefferi, Folium Malloti barbati, Herba Oxalidis Strictae are decocted with water secondary together with ethanol extraction filtering residue, first time add water into medical material weight portion 5-8 doubly, decoct 1.5-2.0 hour, second time adds water as the 3-4 of medical material weight portion doubly decocts 1.0-1.5 hour, collecting decoction, filter, filtrate reduced in volume to relative density is 1.10-1.20 (80 DEG C of survey), adding ethanol makes alcohol content reach 50%, leave standstill 12 hours, filter, after filtrate recycling ethanol, concentrating under reduced pressure becomes dry extract, pulverizes for subsequent use; Get Colophonium drying, pulverizing, cross 100 mesh sieves for subsequent use; By above-mentioned gained fine powder mix homogeneously, add the substrate be made up of lanoline, dimethyl sulfoxine, vaseline, liquid paraffin, Oleum sesami, boil 30 ~ 60min in 70-80 DEG C, naturally cool to room temperature, Chinese medicine ointment of the present invention can be obtained.
Using method: clean wound surface with hydrogen peroxide, iodophor disinfection, remove slough as far as possible, reach that wound surface is fresh ruddyly hemorrhagely to be enriched for standard, again with normal saline cleaning, iodophor disinfection or alcohol disinfecting surrounding skin, be then applied in affected part by Chinese medicinal ointment cotton swab, then with gauze, ointment is covered, in order to avoid make dirty clothes or bedding.
Beneficial effect of the present invention is further illustrated below by way of animal experiment and clinical observation test example.
Animal experiment
The hypersensitive test of Chinese medicinal ointment of the present invention: get healthy albino guinea-pig 30, body weight 250-300g, male and female dual-purpose, reject both sides dorsal body setae before test, every side 3 × 3cm, is divided into test group, blank group and positive controls at random, often organizes 10.Blank group uses the normal saline of 1% to carry out painting hair; Positive controls DNFB, sensitization 1% concentration, excites and uses 0.1% concentration.Test group gets the Chinese medicinal ointment of the embodiment of the present invention 1, gets 0.1g and is applied to unhairing district, back, every day 1 time, totally 3 times, in latter 14 days of last contact, at back, the same area smeared this product 0.1g, at once observe after removing medicine after 6h, and in 1,12,24,48,72h observes with or without anaphylaxis.Blank group and positive controls excite by same method and contact and observe.Result of the test: namely positive controls animal skin occurs localized erythema and slight edema in sensitization after 1 hour, within 24 hours, symptoms of allergic increases the weight of, and have scleroma to be formed, sensitization rate is 100%, all there is not any symptoms of allergic in test group and blank treated animal skin, sensitization rate is 0%.Judge, Chinese medicine composition of the present invention does not have sensitization.
The acute skin irritation test of Chinese medicinal ointment of the present invention: get male 6 of Japan large ear rabbit, body weight 2kg ~ 3kg, hair process is shaved to left dorsal skin, adopt the Chinese medicinal ointment of the embodiment of the present invention 2, to be applied on the left of animal on skin, opposite side in contrast, , adopt blocking test, 5 hours application time, tested material is remained with warm water washing after off-test, 1h after removing tested material, 12h, 24h, 48h and 72h observes the dermoreaction of the tested district of animal and check plot respectively, top average is " 0 ", judge that these product are to animal skin nonirritant.Judge, Chinese medicinal ointment of the present invention does not have zest to skin.
Clinical observation is tested
1. physical data: whole 82 examples are my institute's surgery, General Medicine inpatient, are III phase decubital ulcer, are divided into 2 groups at random.Treatment group 42 example, man 22 example, female 20 example; 51 ~ 75 years old age, average (58.9 ± 6.5) year; Sacrococcygeal region 30 example, hip 12 example; Wherein neck of femur and femur intertrochanteric fracture 4 example, paraplegia 10 example, apoplectic hemiplegia 12 example, tumor 16 example; Ulcer surface 2cm × 2cm ~ 9cm × 10cm, average (54.68 ± 7.66) cm
2.Matched group 40 example, man 21 example, female 19 example; 52 ~ 77 years old age, average (60.4 ± 7.3) year; Sacrococcygeal region 28 example, hip 12 example; Wherein neck of femur and femur intertrochanteric fracture 3 example, paraplegia 9 example, apoplectic hemiplegia 13 example, tumor 15 example; Ulcer surface 2.5cm × 2cm ~ 8.5cm × 11cm, average (55.46 ± 8.34) cm
2.2 groups of physical data comparing difference not statistically significants (P > 0.05), have comparability.
2. diagnostic criteria: reference " Fundamental Nursing " (Zhou Gengsu .[M]. Xi'an: publishing house of The Fourth Military Medical University, 2009).III phase diagnostic criteria: epidermis vesicle expands gradually, ulceration, and dermal wound has yellow exudate, infecting rear surface generally has pus to cover, and cause shallow layer tissue downright bad, ulcer, pain obviously increases the weight of.
3. nursing and Therapeutic Method
3.1 care methods: in patient setup is fresh at air, sun-drenched ward, long-term bedridden patients is placed on motor-driven air-cushion air bed by timing, within every 2 hours, stands up 1 time and notes keeping body to stablize.Lean body mass, easily there is the gerontal patient of pressure ulcer, per hourly stand up 1 time.Patient all establishes and stands up registration card, itemized record bedsore, skin color etc., the position cushion steam circle, cotton pad etc. of commute generation pressure ulcer, keeps bed smooth, clean, dry.Reduce zest factor and comprise replacing incontinent clothing and bedding at any time, keep xerosis cutis, avoid rubbing, protection skin integrity.Instruct family members to like according to patient diet and increase protein-type food products absorption, need to encourage patient to supplement the food of the absorptions easy to digest such as fresh milk, fish, meat medicated porridge, vegetable according to the state of an illness.Strengthen mental nursing simultaneously, thinking clearly patient is often depressed, always think the burden in front yard of oneself getting married, add that skin ulcer face stench, defecation are out of control, inferiority complex strengthens, to this nursing staff apply warm soft intonation, expression in the eyes deeply concerned, optimism emotion carry out infected patient, have a heart-to-heart talk with it during operation, introduce the situation in skin ulcer face, increase its confidence, alleviate inferiority complex.
3.2 Therapeutic Method: two groups of equal Cure the Primary Disease, use antibiotic infection control, complication prevention if desired.
Matched group: application traditional remedies treatment.First clean wound surface with hydrogen peroxide, iodophor disinfection, remove slough as far as possible, reach that wound surface is fresh ruddyly hemorrhagely to be enriched for standard, then with normal saline cleaning, iodophor disinfection, sterile gauze covers, every day 1 time.Treatment group: on treatment of control group basis, Chinese medicinal ointment cotton swab is applied in affected part, then covers ointment with gauze, in order to avoid make dirty clothes or bedding, when exudate is more, can change dressings 1-2 time every day, when exudate is less, can the next day change dressings.
Two groups of equal 7d are 1 course for the treatment of, observe and judge curative effect 3 courses for the treatment of.
4. criterion of therapeutical effect: reference " Fundamental Nursing " (Zhou Gengsu .[M]. Xi'an: publishing house of The Fourth Military Medical University, 2009) formulate.Recovery from illness: fresh granulation tissue all grows, ulcer surface heals; Effective: wound surface reduces >=75%, granulation tissue is fresh, without purulent secretion or reduce obviously; Effective: 25% < wound surface reduces < 75%, granulation tissue comparatively fresh, and clinical symptoms has part to improve; Invalid: wound surface reduces≤25%, before and after treatment, ulcer surface is without significant change or increase the weight of.
5. statistical method application SPSS 15.00 statistical package carries out statistical analysis, measurement data mean ± standard deviation
represent, adopt t inspection; The comparison of enumeration data rate adopts X
2inspection.
6. therapeutic outcome
The comparison of 6.1 liang of group treatment clinical efficacies: as seen from Table 1, treatment group recovery from illness 10 example, effective 22 examples, effective 8 examples, total effective rate is 95.2%, and apparently higher than matched group 72.5%, difference has statistical significance (P < 0.05).
The comparative example (%) of table 1 liang group treatment clinical efficacy
Compare with matched group, * P < 0.05
6.2 liang of group wound healing times compare: treatment group wound healing (13.26 ± 4.48)) d, matched group wound healing (19.76 ± 4.50) d.Treatment group wound healing time comparatively matched group shifts to an earlier date (P < 0.05).
Wound surface Area comparison before and after 6.3 liang of group treatments: wound surface area (54.68 ± 7.66) cm before treatment group treatment
2, wound surface area (13.32 ± 4.49) cm after treatment
2; Wound surface area (55.46 ± 8.34) cm before treatment of control group
2, wound surface area (30.64 ± 8.08) cm after treatment
2.The wound surface area all comparatively front minimizing (P < 0.05) of this group treatment after two groups of treatments, and treatment group reduces more obviously (P < 0.05).
Clinical research also finds: Chinese medicine composition of the present invention can removing toxic substances and promoting tissue regeneration from inside to outside, remove slough, while removing dead crust, improve blood circulation, surrounding tissue nutrition can be improved, enhance metabolism, after promoting decrustation, wound surface newly granulates and grows and tissue regeneration, accelerates repairing ulcer tissue and reaches healing object.
Beneficial effect of the present invention:
1. in side of the present invention, 8 medical materials can be worked in coordination with mutually, interact, medicine heat-clearing and toxic substances removing can be strengthened, change rotten evacuation of pus, the effect of reducing swelling and alleviating pain, holder necrotic tissue and promoting muscle growing, convergenceization trace, to improve microcirculation around wound surface, increases regional flow, the edema that reduces inflammation and local organization ischemia, anoxia, minimizing inflammatory exudation, promote absorption and the dissipation of inflammation.
2. Chinese medicinal ointment of the present invention provides moist environment for wound surface; promote epithelial dividing a word with a hyphen at the end of a line; accelerate the healing of wound surface; do not form crust, play oiliness and act on wound surface top layer formation protecting film, not only protect wound surface moistening; also help the infiltration of medicinal liquid; the new granulation formed can not be damaged when changing dressings, be conducive to the epithelization of wound surface, accelerate the healing of wound surface.
3. clinical experiment shows, Chinese medicinal ointment curative effect of the present invention is fast, effective, safe and reliable, has no side effect.
Detailed description of the invention
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1
Prescription: Herba Maesae Prelarii 12 parts, Viola arcuata (fresh) 15 parts, Colophonium 15 parts, Cortex Garciniae schefferi 18 parts, Folium Malloti barbati 203 parts, Folium Et Cacumen Murrayae 10 parts, Herba Oxalidis Strictae 10 parts, the Radix Angelicae Dahuricae 5 parts.
Preparation method: Folium Et Cacumen Murrayae, Viola arcuata (fresh), the Radix Angelicae Dahuricae are added the ethanol extraction secondary of 75%, each 1.5-2.0 hour, collect ethanol extraction filtering residue, merge extractive liquid, concentrating under reduced pressure becomes dry extract, pulverizes for subsequent use; Herba Maesae Prelarii, Cortex Garciniae schefferi, Folium Malloti barbati, Herba Oxalidis Strictae are decocted with water secondary together with ethanol extraction filtering residue, first time add water into medical material weight portion 5-8 doubly, decoct 1.5-2.0 hour, second time adds water as the 3-4 of medical material weight portion doubly decocts 1.0-1.5 hour, collecting decoction, filter, filtrate reduced in volume to relative density is 1.10-1.20 (80 DEG C of survey), adding ethanol makes alcohol content reach 50%, leave standstill 12 hours, filter, after filtrate recycling ethanol, concentrating under reduced pressure becomes dry extract, pulverizes for subsequent use; Get Colophonium drying, pulverizing, cross 100 mesh sieves for subsequent use; By above-mentioned gained fine powder mix homogeneously, add by lanoline 7 parts, dimethyl sulfoxine 8 parts, 25 parts, vaseline, liquid paraffin 3 parts, Oleum sesami 25 parts of substrate made, boil 30 ~ 60min in 70-80 DEG C, naturally cool to room temperature, Chinese medicine ointment of the present invention can be obtained.
Embodiment 2
Prescription: Herba Maesae Prelarii 11 parts, Viola arcuata (fresh) 17 parts, Colophonium 13 parts, Cortex Garciniae schefferi 16 parts, Folium Malloti barbati 18 parts, Folium Et Cacumen Murrayae 10 parts, Herba Oxalidis Strictae 9 parts, the Radix Angelicae Dahuricae 4 parts.
Preparation method: Folium Et Cacumen Murrayae, Viola arcuata (fresh), the Radix Angelicae Dahuricae are added the ethanol extraction secondary of 75%, each 1.5-2.0 hour, collect ethanol extraction filtering residue, merge extractive liquid, concentrating under reduced pressure becomes dry extract, pulverizes for subsequent use; Herba Maesae Prelarii, Cortex Garciniae schefferi, Folium Malloti barbati, Herba Oxalidis Strictae are decocted with water secondary together with ethanol extraction filtering residue, first time add water into medical material weight portion 5-8 doubly, decoct 1.5-2.0 hour, second time adds water as the 3-4 of medical material weight portion doubly decocts 1.0-1.5 hour, collecting decoction, filter, filtrate reduced in volume to relative density is 1.10-1.20 (80 DEG C of survey), adding ethanol makes alcohol content reach 50%, leave standstill 12 hours, filter, after filtrate recycling ethanol, concentrating under reduced pressure becomes dry extract, pulverizes for subsequent use; Get Colophonium drying, pulverizing, cross 100 mesh sieves for subsequent use; By above-mentioned gained fine powder mix homogeneously, add by lanoline 7 parts, dimethyl sulfoxine 7 parts, 20 parts, vaseline, liquid paraffin 3 parts, Oleum sesami 25 parts of substrate made, boil 30 ~ 60min in 70-80 DEG C, naturally cool to room temperature, Chinese medicine ointment of the present invention can be obtained.
Embodiment 3
Prescription: Herba Maesae Prelarii 13 parts, Viola arcuata (fresh) 20 parts, Colophonium 17 parts, Cortex Garciniae schefferi 15 parts, Folium Malloti barbati 21 parts, Folium Et Cacumen Murrayae 14 parts, Herba Oxalidis Strictae 12 parts, the Radix Angelicae Dahuricae 7 parts.
Preparation method: Folium Et Cacumen Murrayae, Viola arcuata (fresh), the Radix Angelicae Dahuricae are added the ethanol extraction secondary of 75%, each 1.5-2.0 hour, collect ethanol extraction filtering residue, merge extractive liquid, concentrating under reduced pressure becomes dry extract, pulverizes for subsequent use; Herba Maesae Prelarii, Cortex Garciniae schefferi, Folium Malloti barbati, Herba Oxalidis Strictae are decocted with water secondary together with ethanol extraction filtering residue, first time add water into medical material weight portion 5-8 doubly, decoct 1.5-2.0 hour, second time adds water as the 3-4 of medical material weight portion doubly decocts 1.0-1.5 hour, collecting decoction, filter, filtrate reduced in volume to relative density is 1.10-1.20 (80 DEG C of survey), adding ethanol makes alcohol content reach 50%, leave standstill 12 hours, filter, after filtrate recycling ethanol, concentrating under reduced pressure becomes dry extract, pulverizes for subsequent use; Get Colophonium drying, pulverizing, cross 100 mesh sieves for subsequent use; By above-mentioned gained fine powder mix homogeneously, add by lanoline 8 parts, dimethyl sulfoxine 6 parts, 30 parts, vaseline, liquid paraffin 4 parts, Oleum sesami 30 parts of substrate made, boil 30 ~ 60min in 70-80 DEG C, naturally cool to room temperature, Chinese medicine ointment of the present invention can be obtained.
Embodiment 4
Prescription: Herba Maesae Prelarii 12 parts, Viola arcuata (fresh) 18 parts, Colophonium 17 parts, Cortex Garciniae schefferi 17 parts, Folium Malloti barbati 20 parts, Folium Et Cacumen Murrayae 12 parts, Herba Oxalidis Strictae 12 parts, the Radix Angelicae Dahuricae 6 parts.
Preparation method: Folium Et Cacumen Murrayae, Viola arcuata (fresh), the Radix Angelicae Dahuricae are added the ethanol extraction secondary of 75%, each 1.5-2.0 hour, collect ethanol extraction filtering residue, merge extractive liquid, concentrating under reduced pressure becomes dry extract, pulverizes for subsequent use; Herba Maesae Prelarii, Cortex Garciniae schefferi, Folium Malloti barbati, Herba Oxalidis Strictae are decocted with water secondary together with ethanol extraction filtering residue, first time add water into medical material weight portion 5-8 doubly, decoct 1.5-2.0 hour, second time adds water as the 3-4 of medical material weight portion doubly decocts 1.0-1.5 hour, collecting decoction, filter, filtrate reduced in volume to relative density is 1.10-1.20 (80 DEG C of survey), adding ethanol makes alcohol content reach 50%, leave standstill 12 hours, filter, after filtrate recycling ethanol, concentrating under reduced pressure becomes dry extract, pulverizes for subsequent use; Get Colophonium drying, pulverizing, cross 100 mesh sieves for subsequent use; By above-mentioned gained fine powder mix homogeneously, add by lanoline 7 parts, dimethyl sulfoxine 8 parts, 30 parts, vaseline, liquid paraffin 3 parts, Oleum sesami 25 parts of substrate made, boil 30 ~ 60min in 70-80 DEG C, naturally cool to room temperature, Chinese medicine ointment of the present invention can be obtained.
Embodiment 5
Prescription: Herba Maesae Prelarii 15 parts, Viola arcuata (fresh) 20 parts, Colophonium 16 parts, Cortex Garciniae schefferi 18 parts, Folium Malloti barbati 23 parts, Folium Et Cacumen Murrayae 10 parts, Herba Oxalidis Strictae 13 parts, the Radix Angelicae Dahuricae 7 parts.
Preparation method: Folium Et Cacumen Murrayae, Viola arcuata (fresh), the Radix Angelicae Dahuricae are added the ethanol extraction secondary of 75%, each 1.5-2.0 hour, collect ethanol extraction filtering residue, merge extractive liquid, concentrating under reduced pressure becomes dry extract, pulverizes for subsequent use; Herba Maesae Prelarii, Cortex Garciniae schefferi, Folium Malloti barbati, Herba Oxalidis Strictae are decocted with water secondary together with ethanol extraction filtering residue, first time add water into medical material weight portion 5-8 doubly, decoct 1.5-2.0 hour, second time adds water as the 3-4 of medical material weight portion doubly decocts 1.0-1.5 hour, collecting decoction, filter, filtrate reduced in volume to relative density is 1.10-1.20 (80 DEG C of survey), adding ethanol makes alcohol content reach 50%, leave standstill 12 hours, filter, after filtrate recycling ethanol, concentrating under reduced pressure becomes dry extract, pulverizes for subsequent use; Get Colophonium drying, pulverizing, cross 100 mesh sieves for subsequent use; By above-mentioned gained fine powder mix homogeneously, add by lanoline 8 parts, dimethyl sulfoxine 8 parts, 25 parts, vaseline, liquid paraffin 3 parts, Oleum sesami 25 parts of substrate made, boil 30 ~ 60min in 70-80 DEG C, naturally cool to room temperature, Chinese medicine ointment of the present invention can be obtained.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (6)
1. clinical care is used for the treatment of a Chinese medicinal ointment for three phase decubital ulcers, it is characterized in that it is made up of 8 taste medicinal raw materials such as Herba Maesae Prelarii, Viola arcuata (fresh), Colophonium, Cortex Garciniae schefferi, Folium Malloti barbati, Folium Et Cacumen Murrayae, Herba Oxalidis Strictae, the Radixs Angelicae Dahuricae.
2. Chinese medicinal ointment as claimed in claim 1, is characterized in that the medicinal raw material of its following preferred weight part scope is made: Herba Maesae Prelarii 11-15 part, Viola arcuata (fresh) 15-20 part, Colophonium 13-18 part, Cortex Garciniae schefferi 15-20 part, Folium Malloti barbati 18-23 part, Folium Et Cacumen Murrayae 9-15 part, Herba Oxalidis Strictae 8-13 part, Radix Angelicae Dahuricae 4-7 part.
3. Chinese medicinal ointment as claimed in claim 1, is characterized in that the medicinal raw material of its following preferred weight part is made: Herba Maesae Prelarii 12 parts, Viola arcuata (fresh) 15 parts, Colophonium 15 parts, Cortex Garciniae schefferi 18 parts, Folium Malloti barbati 20 parts, Folium Et Cacumen Murrayae 10 parts, Herba Oxalidis Strictae 10 parts, the Radix Angelicae Dahuricae 5 parts.
4. the Chinese medicinal ointment as described in claim 1-3, is characterized in that it also contains the substrate of following preferred weight part: lanoline 5-10 part, dimethyl sulfoxine 6-10 part, vaseline 20-35 part, liquid paraffin 2-5 part, Oleum sesami 20-30 part.
5. the Chinese medicinal ointment as described in claim 1-4, is characterized in that it also contains the substrate of following preferred weight part: lanoline 7 parts, dimethyl sulfoxine 8 parts, 25 parts, vaseline, liquid paraffin 3 parts, Oleum sesami 25 parts.
6. the Chinese medicinal ointment as described in claim 1-5, it is characterized in that its preparation method comprises the following steps: Folium Et Cacumen Murrayae, Viola arcuata (fresh), the Radix Angelicae Dahuricae are added the ethanol extraction secondary of 75%, each 1.5-2.0 hour, collect ethanol extraction filtering residue, merge extractive liquid, concentrating under reduced pressure becomes dry extract, pulverizes for subsequent use; Herba Maesae Prelarii, Cortex Garciniae schefferi, Folium Malloti barbati, Herba Oxalidis Strictae are decocted with water secondary together with ethanol extraction filtering residue, first time add water into medical material weight portion 5-8 doubly, decoct 1.5-2.0 hour, second time adds water as the 3-4 of medical material weight portion doubly decocts 1.0-1.5 hour, collecting decoction, filter, filtrate reduced in volume to relative density is 1.10-1.20 (80 DEG C of survey), adding ethanol makes alcohol content reach 50%, leave standstill 12 hours, filter, after filtrate recycling ethanol, concentrating under reduced pressure becomes dry extract, pulverizes for subsequent use; Get Colophonium drying, pulverizing, cross 100 mesh sieves for subsequent use; By above-mentioned gained fine powder mix homogeneously, add the substrate be made up of lanoline, dimethyl sulfoxine, vaseline, liquid paraffin, Oleum sesami, boil 30 ~ 60min in 70-80 DEG C, naturally cool to room temperature, Chinese medicine ointment of the present invention can be obtained.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022213665A1 (en) * | 2021-04-09 | 2022-10-13 | Xantho Biotechnology Co., Ltd | Use of mangosteen fruit shell extract in the preparation of a medicament for treating bedsores |
| WO2023155158A1 (en) * | 2022-02-18 | 2023-08-24 | Xantho Biotechnology Co., Ltd | Use of mangosteen fruit shell extract in the preparation of a medicament for promoting wound healing in diabetes |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104083630A (en) * | 2014-07-04 | 2014-10-08 | 青岛大学附属医院 | Traditional Chinese medicine ointment for treating bedsore and preparation method thereof |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104083630A (en) * | 2014-07-04 | 2014-10-08 | 青岛大学附属医院 | Traditional Chinese medicine ointment for treating bedsore and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022213665A1 (en) * | 2021-04-09 | 2022-10-13 | Xantho Biotechnology Co., Ltd | Use of mangosteen fruit shell extract in the preparation of a medicament for treating bedsores |
| WO2023155158A1 (en) * | 2022-02-18 | 2023-08-24 | Xantho Biotechnology Co., Ltd | Use of mangosteen fruit shell extract in the preparation of a medicament for promoting wound healing in diabetes |
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Application publication date: 20151021 |