CN113209253B - Traditional Chinese medicine composition for treating burn and scald wound surfaces, traditional Chinese medicine preparation and preparation method - Google Patents
Traditional Chinese medicine composition for treating burn and scald wound surfaces, traditional Chinese medicine preparation and preparation method Download PDFInfo
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Abstract
The application discloses a traditional Chinese medicine composition for treating burn and scald wounds, a traditional Chinese medicine preparation and a preparation method, belongs to the field of traditional Chinese medicines for treating burn and scald wounds, and solves the technical problems of wound infection, dressing change pain and healed scars in deep burn and scald treatment. The traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 24-36 parts of astragalus; 8-12 parts of rheum officinale; 16-24 parts of angelica; 8-12 parts of safflower; 8-12 parts of rhizoma sparganii; 8-12 parts of curcuma zedoary; 12-18 parts of Chinese redbud bark; 8-12 parts of radix angelicae; 8-12 parts of divaricate saposhnikovia root; 16-24 parts of endothelium corneum gigeriae galli. The traditional Chinese medicine composition for treating burn and scald wounds is clinically determined as follows: the wound repairing and healing can be promoted, and the liquefaction and separation of necrotic tissues can be accelerated; can prevent the progressive necrosis of normal tissues, thereby relieving the pain of patients caused by conventional dressing change; and can inhibit and/or kill bacteria on the wound surface, prevent wound surface infection, and after healing, the wound surface skin is soft and flat, has good elasticity and rarely has contracture deformity.
Description
Technical Field
The application belongs to the field of traditional Chinese medicines for treating burn and scald wounds, and particularly relates to a traditional Chinese medicine composition for treating burn and scald wounds, a traditional Chinese medicine preparation and a preparation method.
Background
Burns and scalds are tissue damages caused by factors such as thermal substances, current, radioactive rays and the like, the damaged parts are mainly on skin and mucous membranes, and the serious part can injure subcutaneous or/and submucosal tissues, so the burns and scalds are common multiple surgical diseases. The burn and scald treatment can be divided into I degree burn and scald, superficial II degree burn and scald, deep II degree burn and scald, III degree burn and IV degree burn and scald according to the degree of the burn and scald, wherein the I degree burn and scald refers to the damage of cuticle, stratum lucidum and stratum granulosum of epidermis, and the desquamation can be cured in a short period (3-5 days) without leaving scar; superficial second degree burn and scald comprises the whole epidermis till the injury of the germinal layer or dermal papilla layer, if no infection heals for 1-2 weeks, no scar is left; the deep II degree burn and scald comprises dermal injury below a papillary layer, but partial dermis is remained, if no infection is caused, the dermal injury is healed for 3-4 weeks, scars are remained after healing, if infection is caused, the healing time is prolonged, skin appendages or epithelial islets can be damaged in serious cases, and the wound surface can be healed by a skin grafting method; III degree burn and scald refers to the damage of the whole layer of skin, and the damage of the epidermis, the dermis and the accessories thereof; the IV degree burn and scald means the damage of deep muscles, even bones, internal organs and the like, which endangers the life of a patient. Therefore, effective treatment should be given in time after the occurrence of the burn and scald, so as to prevent the infection of the burn and scald wound and the cicatrization.
At present, the traditional Chinese medicine for treating burns and scalds is generally externally treated by adopting heat-clearing and detoxifying medicines, but the medicines generally have the problems of wound infection susceptibility, wound pain during medicine replacement, healed scars and the like in the process of treating deep burns and scalds.
In view of the above, there is a need for improvement of the existing traditional Chinese medicine for treating burns and scalds, so as to solve the problems of wound infection, dressing change pain and cicatrix after healing in deep burn and scald treatment.
Disclosure of Invention
The application solves the problems of wound infection, wound pain and healed scar when the existing traditional Chinese medicine is used for treating deep burns and scalds through providing the traditional Chinese medicine composition for treating the burns and scalds, the traditional Chinese medicine preparation and the preparation method.
In a first aspect, the embodiment of the application provides a traditional Chinese medicine composition for treating burn and scald wounds, which is prepared from the following raw materials in parts by mass: 24-36 parts of astragalus; 8-12 parts of rheum officinale; 16-24 parts of angelica; 8-12 parts of safflower; 8-12 parts of rhizoma sparganii; 8-12 parts of curcuma zedoary; 12-18 parts of Chinese redbud bark; 8-12 parts of radix angelicae; 8-12 parts of divaricate saposhnikovia root; 16-24 parts of endothelium corneum gigeriae galli.
With reference to the first aspect, in some alternatives of embodiments of the present application, the traditional Chinese medicine composition for treating burn and scald wounds is prepared from the following raw materials in parts by mass: 29-32 parts of astragalus; 9-12 parts of rhubarb; 19-22 parts of angelica; 9-12 parts of safflower; 9-12 parts of rhizoma sparganii; 9-12 parts of curcuma zedoary; 14-16 parts of Chinese redbud bark; 9-12 parts of radix angelicae; 9-12 parts of divaricate saposhnikovia root; 19-22 parts of endothelium corneum gigeriae galli.
With reference to the first aspect, in some alternatives of embodiments of the present application, the traditional Chinese medicine composition for treating burn and scald wounds is prepared from the following raw materials in parts by mass: 30 parts of astragalus; 10 parts of rhubarb; 20 parts of angelica; 10 parts of safflower; 10 parts of rhizoma sparganii; 10 parts of curcuma zedoary; 15 parts of Chinese redbud bark; 10 parts of radix angelicae; 10 parts of divaricate saposhnikovia root; 20 parts of chicken's gizzard-membrane.
The formula mechanism of the traditional Chinese medicine composition for treating burn and scald wounds provided by the embodiment of the application is as follows: radix astragali has the effects of invigorating spleen qi, promoting sore discharge, removing pus, cooling blood, removing toxic substances, removing blood stasis, promoting blood circulation, and inhibiting and killing bacteria, and is used as principal drug; safflower promotes blood circulation, clears the channels, removes blood stasis, relieves pain, inhibits platelet aggregation and enhances fibrinolysis, and angelica sinensis enriches blood, promotes blood circulation, expels pus and promotes granulation, promotes blood circulation, improves skin temperature and promotes wound healing and is a ministerial drug; the rhizoma sparganii and the curcuma zedoary are used for promoting qi circulation, activating blood circulation and removing blood stasis, and the combination of the rhizoma sparganii and the curcuma zedoary can obviously inhibit platelet aggregation and thrombus in vivo and promote local blood circulation; cortex Cercis chinensis has effects of promoting blood circulation, activating qi-flowing, relieving swelling, and removing toxic substances; radix Angelicae Dahuricae has effects of promoting blood circulation, expelling pus, promoting granulation, and relieving pain; wind-proof, wind-dispelling and itching-relieving; endothelium corneum Gigeriae Galli with granulation promoting and wound healing effects is used as adjuvant drug. The medicines are used together to play the efficacies of clearing away heat and toxic material, removing putrefaction and promoting tissue regeneration, and promoting blood circulation and relieving pain, and can not only generate mild stimulation on wound tissues, thereby expanding local blood vessels, promoting capillary circulation, increasing the exudation of local immune bodies, but also strengthen local nutrition, help the absorption of inflammatory products, and promote the regeneration of body tissues and the wound healing.
On the basis of the research, the embodiment of the application also provides the application of the traditional Chinese medicine composition for treating the burn and scald wound in the preparation of the medicine for treating the burn and scald wound.
In a second aspect, the embodiment of the application also provides a medicament for treating burn and scald wounds, which is prepared from the traditional Chinese medicine composition and pharmaceutically acceptable auxiliary materials.
In combination with the second aspect, in some alternatives of embodiments of the present application, the dosage form of the drug includes an ointment, a gel, a film, an emulsion, a powder, and a patch.
In some alternatives of embodiments of the present application in combination with the second aspect, the pharmaceutical dosage form is a paste, and the raw materials for preparing the paste further include a sesame oil.
In a third aspect, an embodiment of the present application further provides a preparation method of a traditional Chinese medicine ointment for treating burn and scald wounds, including:
ball milling radix astragali, radix et rhizoma Rhei, Carthami flos, radix Angelicae sinensis, rhizoma Sparganii, Curcumae rhizoma, cortex Cercis chinensis, radix Angelicae Dahuricae, radix Saposhnikoviae and endothelium corneum Gigeriae Galli to powder particle diameter of 15-50 μm, soaking in appropriate amount of oleum Sesami for 7 days;
heating the soaked sesame oil containing the medicinal powder at 50-75 deg.C until the medicinal powder is slightly charred, and cooling to obtain the medicinal ointment for treating burn and scald.
On the basis of the research of the medicinal ointment, the embodiment of the application also provides a medicinal patch for treating the burn and scald wound surfaces, which comprises the steps of quantitatively and uniformly coating the medicinal ointment on non-woven fabrics and drying at low temperature.
Compared with the prior art, the beneficial effects or advantages of the embodiment of the application include:
the traditional Chinese medicine composition for treating the burn and scald wound surface provided by the embodiment of the application is clinically determined to be capable of accelerating liquefaction and separation of necrotic tissues while promoting wound surface repair and healing and also capable of preventing progressive necrosis of normal tissues, so that pain brought to a patient by conventional dressing change is relieved; the traditional Chinese medicine composition can also inhibit and/or kill wound bacteria, prevent wound infection, and has the advantages of soft and smooth wound skin, good elasticity, less contracture deformity after healing, and good treatment effect on burn and scald wound.
Detailed Description
In order to make those skilled in the art better understand the technical solutions of the embodiments of the present application, the technical solutions of the embodiments of the present application will be clearly and completely described below. It should be apparent that the embodiments described below are only a part of the embodiments of the present application, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
The traditional Chinese medicine raw materials referred to in the description of the following examples are all commercially available medicinal materials, and the examples are not limited.
The embodiment provides a traditional Chinese medicine composition for treating burn and scald wounds, which is prepared from the following raw materials in parts by mass: 24-36 parts of astragalus; 8-12 parts of rheum officinale; 16-24 parts of angelica; 8-12 parts of safflower; 8-12 parts of rhizoma sparganii; 8-12 parts of curcuma zedoary; 12-18 parts of Chinese redbud bark; 8-12 parts of radix angelicae; 8-12 parts of divaricate saposhnikovia root; 16-24 parts of endothelium corneum gigeriae galli.
As an improvement of the embodiment, the traditional Chinese medicine composition for treating burn and scald wounds is prepared from the following raw materials in parts by mass: 29-32 parts of astragalus; 9-12 parts of rhubarb; 19-22 parts of angelica; 9-12 parts of safflower; 9-12 parts of rhizoma sparganii; 9-12 parts of curcuma zedoary; 14-16 parts of Chinese redbud bark; 9-12 parts of radix angelicae; 9-12 parts of divaricate saposhnikovia root; 19-22 parts of endothelium corneum gigeriae galli.
The traditional Chinese medicine composition provided by the embodiment of the application has the following pharmacological effects:
astragalus root: tonifying spleen qi, promoting wound healing and expelling pus.
Rhubarb: cold in nature and bitter in taste; has the effects of cooling blood, removing toxic substances, dispelling blood stasis and dredging channels, and has obvious inhibiting and killing effects on Staphylococcus aureus, enterococcus and the like on the wound surface of burn and scald.
The common burreed rhizome and the zedoary have the effects of breaking blood and promoting qi circulation, removing blood stasis and relieving pain, can obviously inhibit platelet aggregation and thrombus in vivo and can also obviously promote local blood circulation by combining the common burreed rhizome and the zedoary, and the blood circulation is good, so that granulation tissue growth is facilitated, and the effect of promoting wound healing is achieved.
Chinese angelica: warm in nature and sweet in taste; has effects of replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, expelling pus, promoting granulation, promoting blood circulation, increasing skin temperature, and promoting wound healing.
Safflower: warm in nature and pungent in flavor; has effects of promoting blood circulation, dredging channels, removing blood stasis, relieving pain, inhibiting platelet aggregation and enhancing fibrinolysis.
Chinese redbud bark: promoting blood circulation, activating qi-flowing, relieving swelling, removing toxic substances, and inhibiting viruses and bacilli.
Radix angelicae: promoting blood circulation, expelling pus, promoting granulation, relieving pain, inhibiting Escherichia coli, and relieving pain.
Wind prevention: dispel wind and relieve itching, can inhibit various bacteria, and also has obvious antipyretic and analgesic effects.
Endothelium corneum gigeriae galli: promoting tissue regeneration and healing wound, and promoting the regeneration of body tissues due to the abundant protein.
The medicines are combined to play roles of clearing away heat and toxic materials, removing putrefaction, promoting granulation, activating blood circulation and relieving pain. Aiming at treating both principal and secondary aspects of the burn and scald wound surface, and performing purgation and reinforcement simultaneously, thereby accelerating the liquefaction and separation of necrotic tissues while promoting the healing of the wound surface; can prevent the progressive necrosis of normal tissues, thereby relieving the pain of patients caused by conventional dressing change; can also inhibit and/or kill bacteria on the wound surface, prevent wound surface infection, and after healing, the wound surface skin is soft and flat, has good elasticity and rarely has contracture deformity.
In some embodiments provided in the present application, the traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 30 parts of astragalus; 10 parts of rhubarb; 20 parts of angelica; 10 parts of safflower; 10 parts of rhizoma sparganii; 10 parts of curcuma zedoary; 15 parts of Chinese redbud bark; 10 parts of radix angelicae; 10 parts of divaricate saposhnikovia root; 20 parts of chicken's gizzard-membrane.
In some embodiments provided in the present application, the traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 32 parts of astragalus; 12 parts of rhubarb; 22 parts of angelica; 12 parts of safflower; 12 parts of rhizoma sparganii; 12 parts of curcuma zedoary; 16 parts of Chinese redbud bark; 12 parts of radix angelicae; 12 parts of divaricate saposhnikovia root; 22 parts of endothelium corneum gigeriae galli.
In some embodiments provided in the present application, the traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 29 parts of astragalus; 9 parts of rhubarb; 19 parts of Chinese angelica; 9 parts of safflower; 9 parts of rhizoma sparganii; 9 parts of curcuma zedoary; 14 parts of Chinese redbud bark; 9 parts of radix angelicae; 9 parts of divaricate saposhnikovia root; 19 parts of chicken's gizzard-membrane.
In some embodiments provided in the present application, the traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 36 parts of astragalus; 12 parts of rhubarb; 24 parts of angelica; 12 parts of safflower; 12 parts of rhizoma sparganii; 12 parts of curcuma zedoary; 18 parts of Chinese redbud bark; 12 parts of radix angelicae; 12 parts of divaricate saposhnikovia root; 24 parts of chicken's gizzard-membrane.
In some embodiments provided in the present application, the traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 24 parts of astragalus; 8 parts of rhubarb; 16 parts of Chinese angelica; 8 parts of safflower; 8 parts of rhizoma sparganii; 8 parts of curcuma zedoary; 12 parts of Chinese redbud bark; 8 parts of radix angelicae; 8 parts of divaricate saposhnikovia root; 16 parts of chicken's gizzard-membrane.
The traditional Chinese medicine composition for treating burn and scald wounds provided by the embodiment of the application is determined clinically: in the treatment of shallow burns and scalds above II degree, the liquefaction separation of necrotic tissues can be accelerated while the healing of wound surface is promoted; can prevent the progressive necrosis of normal tissues, thereby relieving the pain of patients caused by conventional dressing change; and can also inhibit and/or kill wound bacteria, prevent wound infection, especially after healing, the wound skin is soft and flat, has good elasticity, rarely has contracture deformity, and has remarkable treatment effect on burn and scald wound.
The clinical verification shows that the traditional Chinese medicine composition for treating burn and scald wounds provided by the embodiment of the application is as follows: has obvious effect on treating superficial II degree burn and scald, and short treatment time. Specifically, when the traditional Chinese medicine composition provided by the embodiment of the application is used for treating 3-5 days, the number of wound surface components is increased; when the wound is treated for 6-10 days, the necrotic tissue is liquefied to a peak and is purulent and sticky, and the wound surface has a healing trend; when the treatment is carried out for 15-20 days, granulation tissues of the wound surface are fresh, white epithelium appears around the wound surface, the wound surface gradually shrinks or a skin island appears in the middle of the wound surface, and the synthetic sheet is gradually enlarged to seal the wound surface, or sinus tracts are concavely healed.
The clinical verification shows that the traditional Chinese medicine composition for treating burn and scald wounds provided by the embodiment of the application is as follows: the Chinese medicinal composition can be used for treating burn and scald with soft and smooth skin, good elasticity, and little contracture deformity.
The invention will be further illustrated with reference to specific examples.
Example 1
The embodiment 1 provides a traditional Chinese medicine patch for treating burn and scald wounds, which comprises the following steps:
s1: 30 g of astragalus, 10 g of rhubarb, 10 g of safflower, 20 g of angelica, 10 g of rhizoma sparganii, 10 g of curcuma zedoary, 15 g of Chinese redbud bark, 10 g of angelica dahurica, 10 g of divaricate saposhnikovia root and 20 g of chicken's gizzard-membrane are ball-milled until the particle size of the powder is 15-50 mu m, and then the powder is put into 2000 g of sesame oil to be soaked for 7 days;
s2: heating the soaked sesame oil containing the medicinal powder at 50-75 deg.C until the medicinal powder is slightly charred, and cooling to obtain medicinal paste for treating burn and scald;
s3: and (5) quantitatively and uniformly coating the medicinal paste obtained in the step (S3) on non-woven fabrics, and drying at low temperature to obtain the medicinal paste.
Example 2
The embodiment 2 provides a traditional Chinese medicine patch for treating burn and scald wounds, which comprises the following steps:
s1: grinding 32 g of astragalus, 12 g of rhubarb, 12 g of safflower, 22 g of angelica, 12 g of rhizoma sparganii, 12 g of curcuma zedoary, 16 g of kadsura root-bark, 12 g of angelica dahurica, 12 g of divaricate saposhnikovia root and 22 g of endothelium corneum gigeriae galli into powder with the particle size of 15-50 mu m by a ball mill, and then soaking the powder in 2200 g of sesame oil for 7 days;
s2: heating the soaked sesame oil containing the medicinal powder at 50-75 deg.C until the medicinal powder is slightly charred, and cooling to obtain medicinal paste for treating burn and scald;
s3: and (5) quantitatively and uniformly coating the medicinal paste obtained in the step (S3) on non-woven fabrics, and drying at low temperature to obtain the medicinal paste.
Example 3
The embodiment 3 provides a traditional Chinese medicine patch for treating burn and scald wounds, which comprises the following steps:
s1: grinding 29 g of astragalus, 9 g of rhubarb, 9 g of safflower, 19 g of angelica, 9 g of rhizoma sparganii, 9 g of curcuma zedoary, 14 g of kadsura root-bark, 9 g of angelica dahurica, 9 g of divaricate saposhnikovia root and 19 g of chicken's gizzard-membrane into powder with the particle size of 15-50 mu m by a ball mill, and then soaking the powder in 1800 g of sesame oil for 7 days;
s2: heating the soaked sesame oil containing the medicinal powder at 50-75 deg.C until the medicinal powder is slightly charred, and cooling to obtain medicinal paste for treating burn and scald;
s3: and (5) quantitatively and uniformly coating the medicinal paste obtained in the step (S3) on non-woven fabrics, and drying at low temperature to obtain the medicinal paste.
Example 4
The embodiment 4 provides a traditional Chinese medicine patch for treating burn and scald wounds, which comprises the following steps:
s1: grinding 36 g of astragalus, 12 g of rhubarb, 12 g of safflower, 24 g of angelica, 12 g of rhizoma sparganii, 12 g of curcuma zedoary, 18 g of kadsura root-bark, 12 g of angelica dahurica, 12 g of divaricate saposhnikovia root and 24 g of chicken's gizzard-membrane into powder with the particle size of 15-50 mu m by a ball mill, and then soaking in 2400 g of sesame oil for 7 days;
s2: heating the soaked sesame oil containing the medicinal powder at 50-75 deg.C until the medicinal powder is slightly charred, and cooling to obtain medicinal paste for treating burn and scald;
s3: and (5) quantitatively and uniformly coating the medicinal paste obtained in the step (S3) on non-woven fabrics, and drying at low temperature to obtain the medicinal paste.
Example 5
The embodiment 5 provides a traditional Chinese medicine patch for treating burn and scald wounds, which includes the following steps:
s1: ball-milling 24 g of astragalus, 8 g of rhubarb, 8 g of safflower, 16 g of angelica, 8 g of rhizoma sparganii, 8 g of curcuma zedoary, 12 g of kadsura root-bark, 8 g of angelica dahurica, 8 g of divaricate saposhnikovia root and 16 g of chicken's gizzard-membrane until the particle size of the powder is 15-50 mu m, and soaking in 1500 g of sesame oil for 7 days;
s2: heating the soaked sesame oil containing the medicinal powder at 50-75 deg.C until the medicinal powder is slightly charred, and cooling to obtain medicinal paste for treating burn and scald;
s3: and (5) quantitatively and uniformly coating the medicinal paste obtained in the step (S3) on non-woven fabrics, and drying at low temperature to obtain the medicinal paste.
Example 6
This example 6 provides the application effect of the Chinese medicinal patch prepared in the above examples 1 to 5 in clinical treatment of burns and scalds.
1. Clinical data
The patient data was reviewed by retrospective studies between 1 month 1997 and 12 months 2020. The statistics of the burn and scald cases include 11353 cases, 6265 cases for men and 3821 cases for women.
1.1 age and gender distribution of the statistical cases are shown in Table 1.
TABLE 1 age and sex profiles of statistical cases
1.2 statistical cases the causes of burns and scalds are shown in Table 2.
TABLE 2 statistics of the causes of burns and scalds
1.3 sites of burn and scald in the statistical cases are shown in Table 3.
TABLE 3 statistical cases of burn and scald sites
1.4 burn and scald scores and degrees of the statistical cases are shown in Table 4.
TABLE 4 statistics of the degree and degree of scale of burn and scald
2. Wound surface pretreatment and medication method
2.1 wound surface pretreatment: the burn and scald wound can be cleaned by using decoction of honeysuckle, coptis root or liquorice, and colored liquid medicines such as purple liquid medicine and red liquid medicine are avoided so as not to influence the judgment of the wound degree.
2.2 the medication method comprises the following steps:
2.2.1 superficial second degree burn: when the wound surface has blisters and the blisters are not broken, draining the blister skin of the wound surface and then pasting the drug patch prepared in the example 1; when the skin of the wound is torn off, the wound surface needs to be washed by decoction of honeysuckle, coptis or liquorice, and the like, dry gauze is wiped dry, and then the medicine patch prepared in the example 1 is applied. The dressing change is carried out every 3-5 days.
2.2.2 deep scald of II degrees: when the wound blister is kept complete, draining the wound blister skin and then applying the drug patch prepared in example 1; when the wound-face skin was peeled off, the dry gauze was wiped dry, and the drug patch prepared in example 1 was applied. The dressing change is carried out every 3-5 days.
2.2.3 degree III burn and scald: when the skin of the wound is torn off and the wound surface is white wax, the dry gauze is wiped dry, the medicine patch prepared in the example 1 is applied, and 2-3 layers of gauze are covered to protect the wound surface so as to prevent eschar from forming; when the wound surface is scorched or carbonized, wiping the dry gauze, applying the medicinal patch prepared in the example 1, and covering 2-3 layers of gauze to protect the wound surface; when the eschar liquefied, the drug patch prepared in example 1 was applied. The dressing change is carried out every 3-5 days.
3. Evaluation of therapeutic Effect and adverse reactions
3.1 therapeutic effect standard:
3.1.1 healing: the wound surface is completely healed within 65 days, and no scar is proliferated or scars are not obvious;
3.1.2 effective: the burn wound surface is obviously reduced within 65 days, the symptoms are obviously improved, but the patient is not completely cured;
3.1.3 invalid: the burn wound surface has no change within 65 days.
3.2 wound healing time: the complete healing time of the wound is taken as a time point to evaluate the healing conditions of various wounds.
3.3 pain conditions: inflammatory infiltration of the wound margin was determined by the maximum red swelling and hot pain range of the wound margin and the size (cm) was recorded. In the treatment of pain, the international general method Visual Analogue Scale (VAS) is adopted, a line with the length of 10cm is used, the characters of 0 and 10 are arranged at two ends, 0 represents no pain, 10 represents the most pain, the patient marks the position of the pain at present, and the length of the distance is measured to represent the pain degree. Parents of children judge the position of the pain scale according to the response before and after the dressing change of the children.
4. Therapeutic results
4.1 the results of the treatment are shown in Table 5.
TABLE 5 therapeutic results
Number of examples | Cure of disease | Is effective | Invalidation | Total effective rate | |
Degree I | 729 | 729(100%) | - | - | 100% |
Superficial second degree burn and scald | 3748 | 3249(86.7%) | 492(13.1%) | 7(0.2%) | 99.8% |
Deep second degree burn and scald | 6074 | 5215(85.9%) | 835(13.7%) | 24(0.4%) | 99.6% |
III degree burn and scald | 802 | 684(85.3%) | 107(13.3%) | 11(1.4%) | 98.6% |
Total up to | 11353 | 9877(87.0%) | 1434(12.6%) | 42(0.4%) | 99.6% |
As can be seen from table 5 above, the traditional Chinese medicine composition provided in the embodiment of the present application has a significant effect in treating burn and scald wounds, wherein the cure rate in treating first-degree burns and scalds is as high as 100%, the cure rate in treating superficial second-degree burns and scalds is as high as more than 85.3%, the total effective rate is as high as 98.6%, the total cure rate is 87.0%, and the total effective rate is as high as 99.6%.
4.2 wound healing time is shown in Table 6.
TABLE 6 wound healing time
Degree I | Superficial second degree burn | Deep second degree scald | III degree burn and scald | |
Mean number of dressing changes | 1-3 times | 3-5 times | 7-10 times | 15-20 times |
Maximum healing time | 10 days | 16 days | For 38 days | 63 days |
As can be seen from table 2, in the treatment of burns and scalds, the total healing time of the wound surface is shortest to 10 days and longest to 63 days, so that the treatment of burns and scalds by using the traditional Chinese medicine composition provided by the embodiment of the application has the characteristics of short time and high speed.
4.3 post-treatment day 1, 3 pain scores, detailed in Table 7.
TABLE 7 pain scores on days 1 and 3 post-treatment
As can be seen from table 3, the traditional Chinese medicine composition provided in the embodiment of the present application has a slight pain on the wound surface in days 1 and 3 after administration in the treatment of superficial burns and scalds above ii degree, and the pain is obviously relieved along with the treatment.
The traditional Chinese medicine composition prepared in the examples 2-5 has the same curative effect and comparability with the example 1 in treating burns and scalds.
In addition, by clinical observation records: the traditional Chinese medicine composition provided by the embodiment of the application is used for treating burns and scalds: the medicine is used for 3 to 5 days, the wound surface has more substances, the necrotic tissue is liquefied to a peak after the medicine is used for 6 to 10 days, and the ground granulation tissue begins to be granular, bright red and lustrous and has no edema; gradually reducing the materials in 15-25 days, making the granulation tissue fresh and filling the whole wound surface, and simultaneously making the wound edge epithelial tissue grow and cover the whole wound surface in a creeping manner, and completely healing the wound surface in about 40 days. Therefore, the traditional Chinese medicine composition provided by the embodiment of the application has definite effect on treating burns and scalds, good recovery from infection, less excitation of infection and short hospitalization time.
The examples of the present application also provide the following typical cases to further illustrate the technical effects of the examples of the present application.
Case 1: jiang in some, men and 33 years old mainly caused by 'flame burn and general pain with 40 minutes'. The hospital was admitted at 58 in 2018, 04, 13, 09. The total area of the wound surface of the patient is about 24 percent after the wound surface is positioned on the head, the face, the two upper limbs and the trunk, blisters with different sizes can be seen on the wound surface, the exudation is obvious, and the skin of part of the wound surface blisters is torn off and the tenderness is obvious. The red and white of the wound surface of the upper limbs are mainly white. The porcelain of part wound surface is white, and is dry without seepage. The whole wound surface is mainly deep II degree and III degree burns and scalds. After admission, the drug patch prepared in example 1 was applied for treatment, and the wound surface was completely healed and slightly pigmented for a total of 20 days of admission.
Case 2: in the case of a regular male, the age of 4 years, the main cause of "burn with flame involving pain in many parts of the body for 30 minutes". The hospital was admitted at 14 days 03, 27 and 2018, 21 points. The wound surface of the infant patient is positioned on the face, the two hands, the back of the trunk, the buttocks and the feet, the total area is about 14 percent, blisters with different sizes can be seen on the wound surface, the exudation is obvious, the skin of part of the wound surface blister is torn off, red and white alternative wound bottoms are mainly white, and the tenderness is obvious. The whole wound surface is mainly deep II degree burn and scald. The face edema of the infant patient is obvious, the eyes can not be closed freely, and the infant patient is in a mild shock state. After admission, the drug patch prepared in example 1 was applied for 30 days in total, and the wound surface was completely healed with slight pigmentation.
Case 3: liji, male, 4 years old, from Hubei province, Jingmen, due to "hot liquid scald with pain at many sites of the body for 1 hour". The wound surfaces of the children are positioned on the face neck, the two upper limbs, the trunk, the two hips, the perineum and the two lower limbs, the total area is about 40 percent, blisters with different sizes can be seen on the wound surfaces, most of the skin of the wound face blisters is torn off, and the tenderness is obvious. The whole wound surface is mainly deep II degree burn and scald. After hospitalization, the drug patch prepared in example 1 was administered for 50 days, and the wound surface of the infant patient was well healed.
Case 4: in Shi, men, 35 years old, were burned by electric arc in the two lower limbs, buttocks and other parts of the body in 2017, 05 and 16 days, and were diagnosed in Min Hospital of Gansu province. Patients and family members refuse to receive the skin grafting operation treatment due to high operation cost and intolerable pain of wound surfaces. Referral to my hospital on 19.06/2017. After admission, the wound surface was healed by administering the drug patch prepared in example 1 for a total of 47 days of hospitalization.
Case 5: yang Shi, male, 19 years old, is mainly caused by "flaming burn with pain in many parts of the body for 3 days". The patient was admitted 51 at 20, 03 and 08 in 2018. The wound surface of the patient is positioned on about 35 percent of the total area of the face, the two upper limbs, the two hands, the front part of the trunk, the two lower limbs and the two feet. The wound surface has different sizes of blisters, obvious exudation, and obvious tenderness due to the fact that part of the blisters are torn off. The hands are wax yellow, the local wound surfaces are even carbonized, the dryness is free from exudation, the upper limb wound surface blister skin is torn off, the red and white parts of the wound surface are mainly white, the wound periphery is reddish and dizzy, and the exudation is obvious. The front, the lower limbs and the feet of the trunk are completely torn off, are carbonized and hard like leather, and are dry and free of seepage. The whole wound surface is mainly deep II degree and III degree burns and scalds. After admission, the wound surface was healed up to 35 days after the administration of the drug patch treatment prepared in example 1.
The foregoing is only a preferred embodiment of the present invention, and it will be apparent to those skilled in the art that various modifications and improvements can be made without departing from the principle of the present invention, and such modifications and improvements should be considered as the protection scope of the present invention.
Claims (9)
1. The traditional Chinese medicine composition for treating burn and scald wounds is characterized by being prepared from the following raw materials in parts by mass: 24-36 parts of astragalus; 8-12 parts of rheum officinale; 16-24 parts of angelica; 8-12 parts of safflower; 8-12 parts of rhizoma sparganii; 8-12 parts of curcuma zedoary; 12-18 parts of Chinese redbud bark; 8-12 parts of radix angelicae; 8-12 parts of divaricate saposhnikovia root; 16-24 parts of endothelium corneum gigeriae galli.
2. The traditional Chinese medicine composition for treating burn and scald wounds is characterized by being prepared from the following raw materials in parts by mass: 29-32 parts of astragalus; 9-12 parts of rhubarb; 19-22 parts of angelica; 9-12 parts of safflower; 9-12 parts of rhizoma sparganii; 9-12 parts of curcuma zedoary; 14-16 parts of Chinese redbud bark; 9-12 parts of radix angelicae; 9-12 parts of divaricate saposhnikovia root; 19-22 parts of endothelium corneum gigeriae galli.
3. The traditional Chinese medicine composition for treating burn and scald wounds is characterized by being prepared from the following raw materials in parts by mass: 30 parts of astragalus; 10 parts of rhubarb; 20 parts of angelica; 10 parts of safflower; 10 parts of rhizoma sparganii; 10 parts of curcuma zedoary; 15 parts of Chinese redbud bark; 10 parts of radix angelicae; 10 parts of divaricate saposhnikovia root; 20 parts of chicken's gizzard-membrane.
4. The use of a Chinese medicinal composition for the treatment of burn and scald wounds as claimed in any one of claims 1 to 3 in the preparation of a medicament for the treatment of burn and scald wounds.
5. A medicament for treating burn and scald wounds, which is characterized by comprising the traditional Chinese medicine composition of any one of claims 1 to 3 and pharmaceutically acceptable auxiliary materials.
6. The medicament of claim 5, wherein the medicament is in a dosage form selected from the group consisting of an ointment, a gel, a film, an emulsion, a powder, and a patch.
7. The medicament of claim 6, wherein the medicament is in the form of a paste, and the raw materials for preparing the paste further comprise sesame oil.
8. A method for preparing the paste according to claim 7, comprising:
ball milling radix astragali, radix et rhizoma Rhei, Carthami flos, radix Angelicae sinensis, rhizoma Sparganii, Curcumae rhizoma, cortex Cercis chinensis, radix Angelicae Dahuricae, radix Saposhnikoviae and endothelium corneum Gigeriae Galli to powder particle diameter of 15-50 μm, soaking in appropriate amount of oleum Sesami for 7 days;
heating the soaked sesame oil containing the medicinal powder at 50-75 deg.C until the medicinal powder is slightly charred, and cooling to obtain medicinal paste for treating burn and scald wound.
9. A medicinal patch for treating burn and scald wound, which is characterized in that the medicinal paste prepared according to claim 8 is quantitatively and uniformly applied on non-woven fabrics, and is dried at low temperature.
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