CN117503694A - Traditional Chinese medicine ointment for promoting wound healing after anal fistula or perianal abscess operation - Google Patents
Traditional Chinese medicine ointment for promoting wound healing after anal fistula or perianal abscess operation Download PDFInfo
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- CN117503694A CN117503694A CN202311642126.4A CN202311642126A CN117503694A CN 117503694 A CN117503694 A CN 117503694A CN 202311642126 A CN202311642126 A CN 202311642126A CN 117503694 A CN117503694 A CN 117503694A
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- chinese medicine
- traditional chinese
- wound healing
- anal fistula
- promoting wound
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/44—Elemental carbon, e.g. charcoal, carbon black
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/739—Sanguisorba (burnet)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- Inorganic Chemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract
The invention relates to a traditional Chinese medicine ointment for promoting wound healing after anal fistula or perianal abscess operation, which consists of 2-5 parts by weight of traditional Chinese medicine powder and 5-8 parts by weight of matrix, wherein the formula and the weight ratio of the traditional Chinese medicine powder are mirabilite, baicao cream, dried alum, garden burnet root, and the ratio of the carbon to the ice of Hu Suo =10:3:3:4:4:1, the matrix is a mixture of an oil phase and an aqueous phase, and the whole formula has the effects of drying dampness, healing sores, stopping bleeding, promoting granulation, detumescence and relieving pain.
Description
Technical Field
The invention relates to the field of traditional Chinese medicine ointments, in particular to a traditional Chinese medicine ointment for promoting wound healing after anal fistula or perianal abscess operation and a preparation method thereof.
Background
Anal fistula is a common surgical disorder with the highest incidence among the 20-50 year old population and with a higher prevalence in men than women. Modern medicine holds that the anal gland is infected by bacteria to cause acute infection and suppuration of perianal soft tissue to form perianal abscess, and the drainage pipeline is epithelialized to form anal fistula after surgical drainage, and the obvious pathological characteristics are that the rectum and the perianal skin form an abnormal pipeline consisting of an inner port, a fistula and an outer port. The formation of the fistula hinders the normal work and life of the patient, and at the same time, brings about a heavy psychological burden.
The most main treatment means of anal fistula at present is to remove fistula by surgery on the premise of protecting anal sphincter, so as to ensure the quality of life of patients in the later period. Anal fistulae are often followed by larger open wounds and by large amounts of exudates, which slow wound healing. Therefore, a treatment method for promoting wound healing after anal fistula operation has been a topic of great concern.
Perianal abscess, also known as perianal abscess around the rectum, is called anal abscess in traditional Chinese medicine. Perianal abscess is an acute suppurative infectious disease occurring around the anus, anal canal and rectum, belongs to bacterial infection, and is the precursor of anal fistula. The disease and anal fistula are one of three diseases of anus and intestine, and the incidence rate is about 2 percent, accounting for 8 to 25 percent of the diseases of anus and intestine. Men who are 20 to 40 years old have a 3 to 4 times higher incidence than women, and children have a relatively high incidence.
Perianal abscess should be carefully treated after occurrence, and ischio-rectal fossa and pelvic rectal fossa occurring on both sides of the anus and subperineal abscess on the front side of men are most dangerous, and if not treated in time, can lead to septic shock and even endanger life. The disease belongs to bacterial infection in intestinal tracts, and intestinal bacteria are sources and pathogenic factors. The "anal sinus" is the entrance of infection, and is also the internal orifice after abscess and fistula formation. "anal glands" are the route of infection, which occurs first and then spread. The "perianal space" is the final site of onset. Intestinal bacteria enter the anal sinus to cause inflammation, block the anal gland opening, block the outflow of the anal gland fluid, cause anal gland infection, spread the infection to the perianal space through the muscular space and the lymphatic vessels, and finally form perianal abscess. The treatment of the disease has not been selected much, the cure method is only surgery, and the earlier the better. Therefore, treatment methods for wound healing are also encountered after perianal abscess surgery.
Disclosure of Invention
The invention aims to provide a mineral medicine-containing traditional Chinese medicine ointment for promoting wound healing after anal fistula or perianal abscess operation, and improving sensory experience and clinical treatment effect of patients.
The invention also aims at a preparation method of the mineral-containing traditional Chinese medicine ointment for promoting wound healing after anal fistula or perianal abscess operation, and improving the quality of the ointment.
The invention solves the technical problems by adopting the following technical scheme:
a Chinese medicinal ointment for promoting wound healing after anal fistula or perianal abscess operation comprises 2-5 parts by weight of Chinese medicinal powder and 5-8 parts by weight of matrix.
The traditional Chinese medicine ointment for promoting wound healing after anal fistula or perianal abscess operation comprises the following components by weight ratio of mirabilite, pulvis Fumi Carbonisatus, dried alum, garden burnet, hu Suo borneol=10:3:3:4:4:1.
The matrix of the traditional Chinese medicine ointment for promoting wound healing after anal fistula or perianal abscess operation is a mixture composed of an oil phase and a water phase, wherein the oil phase is composed of white vaseline, stearyl alcohol, glyceryl monostearate and beeswax, and the weight ratio of the white vaseline, the stearyl alcohol, the glyceryl monostearate and the beeswax is as follows: 5-10:20-30:2-8: 5-15.
The water phase is propylene glycol, sodium dodecyl sulfate, triethanolamine and carbomer 940, and the weight ratio of the propylene glycol, the sodium dodecyl sulfate, the triethanolamine and the carbomer 940 is as follows: 25-35:2-8:2-8: 2-5.
The matrix of the traditional Chinese medicine ointment for promoting wound healing after anal fistula or perianal abscess operation is a mixture composed of an oil phase and a water phase, wherein the oil phase is composed of white vaseline, stearyl alcohol, glyceryl monostearate and beeswax, and the weight ratio of the white vaseline, the stearyl alcohol, the glyceryl monostearate and the beeswax is as follows: 8:25:6: 10.
the water phase is propylene glycol, sodium dodecyl sulfate, triethanolamine and carbomer 940, and the weight ratio of the propylene glycol, the sodium dodecyl sulfate, the triethanolamine and the carbomer 940 is as follows: 30:5:5: 3.
the traditional Chinese medicine ointment for promoting wound healing after anal fistula or perianal abscess operation is prepared by the following steps:
(1) Weighing Natrii sulfas, pulvis Fumi Carbonisatus, alumen, radix Sanguisorbae charcoal, rhizoma corydalis, and Borneolum Syntheticum, pulverizing, sieving with No. 9 sieve specified in pharmacopoeia of the people's republic of China of 2020 edition;
(2) Weighing white vaseline, stearyl alcohol, glyceryl monostearate and beeswax, mixing, heating to melt, and maintaining temperature to obtain oil phase;
(3) Weighing propylene glycol, sodium dodecyl sulfate, triethanolamine and carbomer 940, and adding a proper amount of pure water; mixing, heating to dissolve and preserving heat to obtain a water phase;
(4) Mixing the oil phase and the water phase under vacuum condition and stirring, and stirring and cooling to about 50-60deg.C to obtain cream matrix;
(5) And (3) adding the traditional Chinese medicine powder prepared in the step (1) into the cream matrix prepared in the step (4), and stirring to obtain the traditional Chinese medicine ointment.
The application of the traditional Chinese medicine ointment for promoting the wound healing after anal fistula or perianal abscess operation in preparing the medicine for promoting the wound healing after anal fistula or perianal abscess operation.
Natrii Sulfas (Natrii Sulfas) is crystal prepared by processing and refining sulfate mineral Natrii Sulfas. Mainly contains sodium sulfate (Na) 2 SO 4 ·10H 2 O). Salty, bitter and cold. Enter stomach and large intestine meridians. Has the effects of relieving constipation, moistening dryness, softening hard mass, clearing pathogenic fire and relieving swelling. Is mainly used for excessive heat accumulation, abdominal distending pain, constipation, swelling and pain of intestinal abscess and the like; it is indicated for acute mastitis and hemorrhoids with swelling and pain.
The Plant Soot is soft coal formed under an iron pan for burning firewood or black ash in a chimney. Pungent and warm. Enters the lung, stomach and large intestine meridians. Has hemostatic and antidiarrheal effects. Is mainly used for hemoptysis, hematemesis, epistaxis and traumatic hemorrhage.
Alumen (Calcine aluminum) contains aqueous aluminum potassium sulfate [ KAl (SO) 4 ) 2 ·12H 2 O]Alum calcined product of (2). The medicinal material base is mineral alunite, and is processed and refined to obtain the crystal. Sour, astringent and cold. Enter lung, spleen, liver and large intestine meridians. Has effects of eliminating dampness, healing sore, stopping bleeding, and eliminating slough. Is mainly used for eczema, wet sore, rectocele, hemorrhoids, purulent ear, pruritus vulvae, leukorrhagia, epistaxis and meat.
The radix Sanguisorbae charcoal (Radix Sanguisorbae Carbonisata) is prepared from dried root of radix Sanguisorbae of Rosaceae. Bitter, sour, astringent and slightly cold. Enter liver and large intestine meridians. Has effects of cooling blood, stopping bleeding, removing toxic substances, and healing sore. Is mainly used for hematochezia, hemorrhoidal bleeding, bloody dysentery, metrorrhagia, burns and scalds, carbuncles, swelling and sore toxin.
Rhizoma corydalis (Corydalis Rhizoma) is dry tuber of corydalis tuber of Papaveraceae. Pungent and bitter, warm. Enter liver and spleen meridians. Has effects of promoting blood circulation, activating qi-flowing, and relieving pain. Is mainly used for chest and hypochondrium pain, epigastric pain, chest pain, amenorrhea dysmenorrhea, postpartum blood stasis and traumatic injury.
Borneol (Borneolum Syntheticum), namely synthetic borneol. Pungent, bitter and slightly cold. It enters heart, spleen and lung meridians. Has effects of inducing resuscitation, refreshing mind, clearing heat and relieving pain. It is mainly used for treating febrile diseases such as unconsciousness, convulsion, apoplexy, phlegm syncope, qi Yu Bao syncope, middle-jiao malignant coma, chest pain, conjunctival congestion, aphtha, sore throat, and ear canal purulence.
The medicinal materials all meet pharmacopoeia standards or provincial drug standards.
The beneficial effects are that:
1. as recorded in the "the theory of disease sources", sores and ulcers are all caused by wind-dampness, blood-qi and heat accumulation, and the muscles of the patients are sores, and the patients are not in charge for a long time, and have malignant flesh, protruding four sides, and good flesh is not generated. The toxic heat is not complete, the channels and collaterals are still blocked, and the blood and qi are not sufficient. Anal fistula is usually caused by pus and ulcer of anal abscess, and by pus and blood stasis, which results in difficult circulation of qi and blood, long stagnation of damp-heat pathogen, long-term non-healing wound and long-term leakage. Anal fistula can be classified into downward flow of damp-heat, deficiency of vital qi and evil, deficiency of yin fluid, and postoperative weakness, qi stagnation and blood stasis, yang deficiency and yin exuberance, manifested as postoperative pain, local congestion, swelling, chronic wound, etc. in the differentiation of symptoms of traditional Chinese medicine.
The traditional Chinese medicine Wang Yehuang teaching of the old Chinese medicine of the name of Jiangsu province of the anorectal department of the south Beijing Chinese medical university (attached to the south Beijing Chinese medical university) combines years of clinical experience to provide the treatment prescription under the guidance of the theory of traditional Chinese medicine, takes the effects of eliminating dampness, healing sore, stopping bleeding, promoting granulation, reducing swelling and relieving pain as treatment rules, can promote the healing of wound surfaces, and can also improve symptoms such as swelling and pain of wound surfaces, exudation pruritus, bleeding and the like after anal fistula or perianal abscess operation. The product is prepared from 6 traditional Chinese medicines of mirabilite, pulvis Fumi Carbonisatus, dried alum, carbonized sanguisorba root, rhizoma corydalis and borneol, wherein the medicine ratio of the prescription is 10:3:3:4:4:1. In the recipe, mirabilite is salty in taste, bitter and cold in nature, and is mainly used for relieving fever, dissipating blood stasis, and clearing heat and detumescence. Baicao frosty is pungent and warm in nature, can remove heat from delusions, stop bleeding, has the effects of astringing to stop bleeding, detoxify and dissipate fire. The two are used together as monarch drugs, and the two drugs can clear heat, dissipate fire, reduce swelling and relieve pain. The ministerial drugs are garden burnet charcoal and dried alum. The garden burnet root charcoal has bitter taste, cold property, strong astringency and hemostasis, and has the effects of cooling blood and stopping bleeding, clearing heat and detoxicating, and detumescence and healing sore; the dried alum is sour and astringent, has cold property, has the effects of astringing, drying dampness and relieving itching, and is externally used for treating epistaxis, sores on the mouth and tongue, hemorrhoids and mange. Combining the two, combining the monarch drugs to purge fire, eliminate carbuncles, stop bleeding, heal sores and also to relieve pain. Yan Hu has warm nature and bitter and pungent taste, can dispel heat and unblock, activate blood and promote qi circulation, and has strong action of relieving pain. Borneol has bitter and pungent taste and cold nature, has the effects of clearing heat and dispelling toxin, can be used for treating sore and ulcer pain, and unhealed ulcer, and also has the effects of clearing heat and detoxicating, and preventing corrosion and promoting granulation, and is used as an adjuvant drug. The medicines are combined together, and the whole formula has the effects of drying dampness, healing sore, stopping bleeding, promoting granulation, reducing swelling and relieving pain.
2. At present, the prescription is mainly applied to an affected part in clinical application by powder, the use experience of a patient is poor, and a new wound surface which is primarily healed is easy to be cracked again due to insufficient lubrication and moisture retention. The ointment prepared from the medicinal composition has the effects of lubricating and moisturizing, prevents skin adhesion and dryness, greatly improves the use experience of patients, and enhances the clinical use effect.
3. The high drug-loading traditional Chinese medicine formula ointment for treating anal fistula or perianal abscess disclosed by the invention improves the uniformity of drug use by matching the interaction of the traditional Chinese medicine formula, the oil phase and the water phase, and simultaneously increases the lubricity and the moisture retention property by the interaction of auxiliary materials, reduces the medication pain of patients and improves the treatment effect.
Drawings
FIG. 1 is a diagram of ointment
FIG. 2A is a graph showing the effect of the ointment on clinical use of patients
FIG. 3A is a graph showing the effect of the ointment on clinical use of patients
FIG. 4 is a graph showing the effect of the ointment on clinical use of patients
Detailed Description
The invention is further described below in conjunction with the detailed description. It is to be understood that these examples are illustrative of the present invention and are not intended to limit the scope of the present invention. Further, it is understood that various changes and modifications of the present invention may be made by those skilled in the art after reading the description of the present invention, and that such equivalents are intended to fall within the scope of the claims appended hereto.
Example 1
(1) Weighing Natrii sulfas, alumen, radix Sanguisorbae preparata, hu Suo Borneolum Syntheticum=10:3:3:4:4:1, pulverizing, and sieving with No. 9 sieve specified in pharmacopoeia of the people's republic of China in 2020;
(2) Weighing white vaseline according to the weight portion ratio: stearyl alcohol: glyceryl monostearate: beeswax=5:30:2: 15, mixing, heating to melt and preserving heat to obtain an oil phase;
(3) The propylene glycol is weighed according to the weight portion: sodium dodecyl sulfate: triethanolamine: carbomer 940=25:8:2: 5, adding pure water accounting for 20% of the weight of the water phase; mixing, heating to dissolve and preserving heat to obtain a water phase;
(4) Mixing the oil phase and the water phase under vacuum condition and stirring, and stirring and cooling to about 50 ℃ to obtain a cream matrix;
(5) Adding 2 parts by weight of the traditional Chinese medicine powder prepared in the step (1) into 8 parts by weight of the cream matrix prepared in the step (4), and stirring to obtain the traditional Chinese medicine ointment.
Example 2
(1) Weighing Natrii sulfas, alumen, radix Sanguisorbae preparata, hu Suo Borneolum Syntheticum=10:3:3:4:4:1, pulverizing, and sieving with No. 9 sieve specified in pharmacopoeia of the people's republic of China in 2020;
(2) Weighing white vaseline according to the weight portion ratio: stearyl alcohol: glyceryl monostearate: beeswax=10:20:8: 5, mixing, heating to melt and preserving heat to obtain an oil phase;
(3) The propylene glycol is weighed according to the weight portion: sodium dodecyl sulfate: triethanolamine: carbomer 940 = 35:2:8: 2, adding pure water accounting for 20% of the weight of the water phase; mixing, heating to dissolve and preserving heat to obtain a water phase;
(4) Mixing the oil phase and the water phase under vacuum condition and stirring, and stirring and cooling to about 60 ℃ to obtain a cream matrix;
(5) And (3) adding 5 parts by weight of the traditional Chinese medicine powder prepared in the step (1) into 5 parts by weight of the cream matrix prepared in the step (4), and stirring to obtain the traditional Chinese medicine ointment.
Example 3
(1) Weighing Natrii sulfas, alumen, radix Sanguisorbae preparata, hu Suo Borneolum Syntheticum=10:3:3:4:4:1, pulverizing, and sieving with No. 9 sieve specified in pharmacopoeia of the people's republic of China in 2020;
(2) Weighing white vaseline according to the weight portion ratio: stearyl alcohol: glyceryl monostearate: beeswax=7:25:5: 10, mixing, heating to melt and preserving heat to obtain an oil phase;
(3) The propylene glycol is weighed according to the weight portion: sodium dodecyl sulfate: triethanolamine: carbomer 940 = 30:5:5: 3, adding pure water accounting for 20% of the weight of the water phase; mixing, heating to dissolve and preserving heat to obtain a water phase;
(4) Mixing the oil phase and the water phase under vacuum condition and stirring, and stirring and cooling to about 55deg.C to obtain cream matrix;
(5) Adding 3 parts by weight of the traditional Chinese medicine powder prepared in the step (1) into 7 parts by weight of the cream matrix prepared in the step (4), and stirring to obtain the traditional Chinese medicine ointment, wherein the figure is shown in the accompanying figure 1.
Comparative example 1:
(1) Weighing Natrii sulfas, alumen, radix Sanguisorbae preparata, hu Suo Borneolum Syntheticum=10:3:3:4:4:1, pulverizing, and sieving with No. 9 sieve specified in pharmacopoeia of the people's republic of China in 2020;
(2) Weighing white vaseline according to the weight portion ratio: beeswax=7:10, mixing, heating to melt, and maintaining the temperature to obtain oil phase;
(3) The propylene glycol is weighed according to the weight portion: sodium dodecyl sulfate=30:5, adding pure water 20% by weight of the aqueous phase; mixing, heating to dissolve and preserving heat to obtain a water phase;
(4) Mixing the oil phase and the water phase under vacuum condition and stirring, and stirring and cooling to about 55deg.C to obtain cream matrix;
(5) And (3) adding 3 parts by weight of the traditional Chinese medicine powder prepared in the step (1) into 7 parts by weight of the cream matrix prepared in the step (4), and stirring to obtain the traditional Chinese medicine ointment.
Comparative example 2
(1) Weighing Natrii sulfas, alumen, radix Sanguisorbae preparata, hu Suo Borneolum Syntheticum=10:3:3:4:4:1, pulverizing, and sieving with No. 9 sieve specified in pharmacopoeia of the people's republic of China in 2020;
(2) Weighing stearyl alcohol according to the weight portion: glyceryl monostearate=25:5, mixing, heating to melt, and maintaining the temperature to obtain oil phase;
(3) Weighing triethanolamine according to the weight portion: carbomer 940 = 5:3, adding pure water accounting for 20% of the weight of the water phase; mixing, heating to dissolve and preserving heat to obtain a water phase;
(4) Mixing the oil phase and the water phase under vacuum condition and stirring, and stirring and cooling to about 55deg.C to obtain cream matrix;
(5) And (3) adding 3 parts by weight of the traditional Chinese medicine powder prepared in the step (1) into 7 parts by weight of the cream matrix prepared in the step (4), and stirring to obtain the traditional Chinese medicine ointment.
Example 4:
1. the sensory, ductility and stability of the Chinese medicinal ointment were evaluated according to the following evaluation criteria of table 1.
Table 1 evaluation method
2. The evaluation results are shown in Table 2
Table 2 sensory, ductility and stability of each group of Chinese medicinal ointments
| Group of | Sensory sense | Ductility | Stability of | Score of |
| Example 1 | 26 | 18 | 48 | 92 |
| Example 2 | 25 | 17 | 49 | 91 |
| Example 3 | 28 | 18 | 48 | 94 |
| Comparative example 1 | 24 | 15 | 36 | 75 |
| Comparative example 2 | 23 | 18 | 38 | 79 |
Conclusion: the traditional Chinese medicine ointment prepared by the invention has better sense, ductility and stability than those of the comparative examples, can play a role in lubrication and moisture retention, prevents skin adhesion and dryness, greatly improves the use experience of patients, and enhances the clinical use effect.
Example 5
Patients who had a single fistula on XX, male, age 23, had an anal fistula for one year, were examined as a low-grade simple fistula, and decided to have the fistula surgically removed. The next day after operation of the patient, the wound surface is disinfected by using 0.5% iodophor cotton balls, the traditional Chinese medicine ointment prepared in the embodiment 3 is uniformly smeared on sterilized vaseline oil gauze with the thickness of about 1-2mm, then the vaseline oil gauze dipped with the medicine is coated on the wound surface, the tightness is proper, the outside is covered and fixed by using sterile dry gauze, and the dressing is changed once in the morning and afternoon every day until the wound surface heals. The patient developed about 9.32cm post-operatively 2 Is about 5.17cm in wound area after 14 days of administration 2 The wound healing rate was 44.5%, see figure 2 for details, secretion was reduced and pain was relieved.
Example 6
Patient XX, male, age 30, had anal fistula for 7 days, and was examined as a low-grade simple anal fistula, and decided to surgically remove the fistula. The next day after operation of the patient, the wound surface is disinfected by using 0.5% iodophor cotton balls, the traditional Chinese medicine ointment prepared in the embodiment 3 is uniformly smeared on sterilized vaseline oil gauze with the thickness of about 1-2mm, then the vaseline oil gauze dipped with the medicine is coated on the wound surface, the tightness is proper, the outside is covered and fixed by using sterile dry gauze, and the dressing is changed once in the morning and afternoon every day until the wound surface heals. The patient developed about 8.57cm post-operatively 2 Is about 5.33cm in wound area after 14 days of administration 2 The wound healing rate was 37.8%, see in particular figure 3, secretion was reduced and pain was relieved.
Example 7
The patient is Lv XX, a male, 36 years old, has perianal abscess for 5 days, is checked to be pelvic rectal gap abscess, is decided to cut open and drain a hanging line in perianal abscess operation, the wound surface is conventionally disinfected by 0.5% iodophor cotton balls after the second day after operation of the patient, the traditional Chinese medicine ointment prepared in the embodiment 3 is uniformly smeared on sterilized vaseline oil gauze, the thickness of the smeared medicine is about 1-2mm, then the vaseline oil gauze dipped with the medicine is smeared on the wound surface, the tightness is proper, the outside is covered and fixed by sterile dry gauze, and the medicine is changed once in the morning and afternoon every day until the wound surface heals. The patient is operated onAfter which about 25.32cm is formed 2 Is about 19.01cm in wound area 25 days after administration 2 The wound healing rate was 24.82%, see fig. 4 in particular, secretion was reduced and pain was relieved.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (8)
1. A traditional Chinese medicine ointment for promoting wound healing after anal fistula or perianal abscess operation is characterized by comprising 2-5 parts by weight of traditional Chinese medicine powder and 5-8 parts by weight of matrix.
2. The traditional Chinese medicine ointment for promoting wound healing after anal fistula or perianal abscess operation according to claim 1, wherein the traditional Chinese medicine powder formula and the weight ratio are mirabilite, baicao cream, dried alum, garden burnet charcoal, hu Suo borneol=10:3:3:4:4:1.
3. The traditional Chinese medicine ointment for promoting wound healing after anal fistula or perianal abscess operation according to claim 1, wherein the matrix is a mixture composed of an oil phase and a water phase, the oil phase is composed of white vaseline, stearyl alcohol, glyceryl monostearate and beeswax, and the weight ratio of the white vaseline, the stearyl alcohol, the glyceryl monostearate and the beeswax is as follows: 5-10:20-30:2-8: 5-15.
4. The traditional Chinese medicine ointment for promoting wound healing after anal fistula or perianal abscess operation according to claim 3, wherein the water phase is propylene glycol, sodium dodecyl sulfate, triethanolamine, carbomer 940, and the weight ratio of the propylene glycol, the sodium dodecyl sulfate, the triethanolamine and the carbomer 940 is: 25-35:2-8:2-8: 2-5.
5. The traditional Chinese medicine ointment for promoting wound healing after anal fistula or perianal abscess operation according to claim 3, wherein the matrix is a mixture of an oil phase and a water phase, the oil phase is composed of white vaseline, stearyl alcohol, glyceryl monostearate and beeswax, and the weight ratio of the white vaseline, the stearyl alcohol, the glyceryl monostearate and the beeswax is as follows: 8:25:6: 10.
6. the traditional Chinese medicine ointment for promoting wound healing after anal fistula or perianal abscess operation according to claim 4, wherein the water phase is propylene glycol, sodium dodecyl sulfate, triethanolamine, carbomer 940, and the weight ratio of the propylene glycol, the sodium dodecyl sulfate, the triethanolamine and the carbomer 940 is: 30:5:5: 3.
7. the traditional Chinese medicine ointment for promoting wound healing after anal fistula or perianal abscess operation according to claim 2, 3 or 4, wherein the preparation method is as follows:
(1) Weighing Natrii sulfas, pulvis Fumi Carbonisatus, alumen, radix Sanguisorbae charcoal, rhizoma corydalis, and Borneolum Syntheticum, pulverizing, sieving with No. 9 sieve specified in pharmacopoeia of the people's republic of China of 2020 edition;
(2) Weighing white vaseline, stearyl alcohol, glyceryl monostearate and beeswax, mixing, heating to melt, and maintaining temperature to obtain oil phase;
(3) Weighing propylene glycol, sodium dodecyl sulfate, triethanolamine and carbomer 940, and adding a proper amount of pure water; mixing, heating to dissolve and preserving heat to obtain a water phase;
(4) Mixing the oil phase and the water phase under vacuum condition and stirring, and stirring and cooling to about 50-60deg.C to obtain cream matrix;
(5) And (3) adding the traditional Chinese medicine powder prepared in the step (1) into the cream matrix prepared in the step (4), and stirring to obtain the traditional Chinese medicine ointment.
8. The use of a traditional Chinese medicine ointment for promoting wound healing after anal fistula or perianal abscess according to claim 1 in the preparation of a medicament for promoting wound healing after anal fistula or perianal abscess.
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