CN108355106B - Traditional Chinese medicine formula for ventilating lung and abating fever - Google Patents
Traditional Chinese medicine formula for ventilating lung and abating fever Download PDFInfo
- Publication number
- CN108355106B CN108355106B CN201810211552.5A CN201810211552A CN108355106B CN 108355106 B CN108355106 B CN 108355106B CN 201810211552 A CN201810211552 A CN 201810211552A CN 108355106 B CN108355106 B CN 108355106B
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- traditional chinese
- lung
- fever
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003814 drug Substances 0.000 title claims abstract description 61
- 206010037660 Pyrexia Diseases 0.000 title claims abstract description 33
- 210000004072 lung Anatomy 0.000 title claims abstract description 29
- 206010035664 Pneumonia Diseases 0.000 claims abstract description 21
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 12
- 239000000203 mixture Substances 0.000 claims abstract description 12
- 244000144725 Amygdalus communis Species 0.000 claims abstract description 10
- 235000011437 Amygdalus communis Nutrition 0.000 claims abstract description 10
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 10
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 10
- 235000020224 almond Nutrition 0.000 claims abstract description 10
- 229910052602 gypsum Inorganic materials 0.000 claims abstract description 10
- 239000010440 gypsum Substances 0.000 claims abstract description 10
- 241000218671 Ephedra Species 0.000 claims abstract description 9
- 229940079593 drug Drugs 0.000 claims abstract description 9
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 9
- 235000011477 liquorice Nutrition 0.000 claims abstract description 9
- 241000255789 Bombyx mori Species 0.000 claims abstract description 8
- 206010006451 bronchitis Diseases 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 238000009835 boiling Methods 0.000 claims description 2
- 239000000706 filtrate Substances 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 2
- 239000011707 mineral Substances 0.000 claims description 2
- 239000011148 porous material Substances 0.000 claims description 2
- 238000002791 soaking Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 44
- 231100000331 toxic Toxicity 0.000 abstract description 7
- 230000002588 toxic effect Effects 0.000 abstract description 7
- 230000002829 reductive effect Effects 0.000 abstract description 6
- 239000003242 anti bacterial agent Substances 0.000 abstract description 4
- 229940088710 antibiotic agent Drugs 0.000 abstract description 4
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 3
- 241000721047 Danaus plexippus Species 0.000 abstract description 2
- 208000011580 syndromic disease Diseases 0.000 description 27
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 22
- 201000010099 disease Diseases 0.000 description 21
- 206010011224 Cough Diseases 0.000 description 20
- 208000024891 symptom Diseases 0.000 description 20
- 208000000059 Dyspnea Diseases 0.000 description 12
- 206010013975 Dyspnoeas Diseases 0.000 description 12
- 206010062717 Increased upper airway secretion Diseases 0.000 description 11
- 208000026435 phlegm Diseases 0.000 description 11
- 210000004369 blood Anatomy 0.000 description 9
- 239000008280 blood Substances 0.000 description 9
- 230000009467 reduction Effects 0.000 description 8
- 238000003745 diagnosis Methods 0.000 description 7
- 230000001754 anti-pyretic effect Effects 0.000 description 6
- 239000002221 antipyretic Substances 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 230000001717 pathogenic effect Effects 0.000 description 6
- 238000009825 accumulation Methods 0.000 description 5
- 235000009508 confectionery Nutrition 0.000 description 5
- 230000001737 promoting effect Effects 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 208000037656 Respiratory Sounds Diseases 0.000 description 4
- 230000009471 action Effects 0.000 description 4
- 208000006673 asthma Diseases 0.000 description 4
- 230000035876 healing Effects 0.000 description 4
- 210000002216 heart Anatomy 0.000 description 4
- 238000001990 intravenous administration Methods 0.000 description 4
- 210000003205 muscle Anatomy 0.000 description 4
- 206010037833 rales Diseases 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- 208000008203 tachypnea Diseases 0.000 description 4
- 206010043089 tachypnoea Diseases 0.000 description 4
- 201000004813 Bronchopneumonia Diseases 0.000 description 3
- 206010011703 Cyanosis Diseases 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 206010036790 Productive cough Diseases 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 230000000172 allergic effect Effects 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 208000010668 atopic eczema Diseases 0.000 description 3
- 210000000038 chest Anatomy 0.000 description 3
- 230000004087 circulation Effects 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 229940093181 glucose injection Drugs 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 210000000265 leukocyte Anatomy 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 230000035900 sweating Effects 0.000 description 3
- 230000035922 thirst Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 241000255791 Bombyx Species 0.000 description 2
- 241000202726 Bupleurum Species 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 241000204031 Mycoplasma Species 0.000 description 2
- 206010052319 Nasal flaring Diseases 0.000 description 2
- 206010061876 Obstruction Diseases 0.000 description 2
- 206010068319 Oropharyngeal pain Diseases 0.000 description 2
- 206010057009 Pharyngeal erythema Diseases 0.000 description 2
- 201000007100 Pharyngitis Diseases 0.000 description 2
- 241000448536 Pyrrholaemus brunneus Species 0.000 description 2
- 206010047924 Wheezing Diseases 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 239000003443 antiviral agent Substances 0.000 description 2
- 238000002555 auscultation Methods 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 238000004820 blood count Methods 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000008595 infiltration Effects 0.000 description 2
- 238000001764 infiltration Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 238000002601 radiography Methods 0.000 description 2
- 208000013220 shortness of breath Diseases 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 208000024794 sputum Diseases 0.000 description 2
- 210000003802 sputum Anatomy 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 description 1
- 206010063659 Aversion Diseases 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 108010074051 C-Reactive Protein Proteins 0.000 description 1
- 102100032752 C-reactive protein Human genes 0.000 description 1
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- URDOHUPGIOGTKV-JTBFTWTJSA-M Cefuroxime sodium Chemical compound [Na+].N([C@@H]1C(N2C(=C(COC(N)=O)CS[C@@H]21)C([O-])=O)=O)C(=O)\C(=N/OC)C1=CC=CO1 URDOHUPGIOGTKV-JTBFTWTJSA-M 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 241000606161 Chlamydia Species 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 241000576429 Forsythia suspensa Species 0.000 description 1
- 206010060891 General symptom Diseases 0.000 description 1
- 241000288140 Gruiformes Species 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 235000017443 Hedysarum boreale Nutrition 0.000 description 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 description 1
- 206010020741 Hyperpyrexia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010024264 Lethargy Diseases 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- 206010025421 Macule Diseases 0.000 description 1
- 241001481296 Malus spectabilis Species 0.000 description 1
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 description 1
- 208000007125 Neurotoxicity Syndromes Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 206010054107 Nodule Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 244000046146 Pueraria lobata Species 0.000 description 1
- 235000010575 Pueraria lobata Nutrition 0.000 description 1
- 208000004756 Respiratory Insufficiency Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 208000032023 Signs and Symptoms Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 206010044221 Toxic encephalopathy Diseases 0.000 description 1
- 231100000076 Toxic encephalopathy Toxicity 0.000 description 1
- 206010044684 Trismus Diseases 0.000 description 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000000137 annealing Methods 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 229940124350 antibacterial drug Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 229960004099 azithromycin Drugs 0.000 description 1
- MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N benzo-alpha-pyrone Natural products C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 229960004755 ceftriaxone Drugs 0.000 description 1
- VAAUVRVFOQPIGI-SPQHTLEESA-N ceftriaxone Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC1=NC(=O)C(=O)NN1C VAAUVRVFOQPIGI-SPQHTLEESA-N 0.000 description 1
- 229960000534 cefuroxime sodium Drugs 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 235000001368 chlorogenic acid Nutrition 0.000 description 1
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 1
- 229940074393 chlorogenic acid Drugs 0.000 description 1
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 description 1
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 235000001671 coumarin Nutrition 0.000 description 1
- 150000004775 coumarins Chemical class 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 description 1
- 210000003714 granulocyte Anatomy 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000020169 heat generation Effects 0.000 description 1
- 210000000777 hematopoietic system Anatomy 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 229930013686 lignan Natural products 0.000 description 1
- 235000009408 lignans Nutrition 0.000 description 1
- 150000005692 lignans Chemical class 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 238000001325 log-rank test Methods 0.000 description 1
- LRDGATPGVJTWLJ-UHFFFAOYSA-N luteolin Natural products OC1=CC(O)=CC(C=2OC3=CC(O)=CC(O)=C3C(=O)C=2)=C1 LRDGATPGVJTWLJ-UHFFFAOYSA-N 0.000 description 1
- 235000009498 luteolin Nutrition 0.000 description 1
- -1 luteolin glycoside Chemical class 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 238000004634 pharmacological analysis method Methods 0.000 description 1
- 208000008423 pleurisy Diseases 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000002633 protecting effect Effects 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 208000010540 rapid respiration Diseases 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 201000004193 respiratory failure Diseases 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 208000020029 respiratory tract infectious disease Diseases 0.000 description 1
- HEBKCHPVOIAQTA-ZXFHETKHSA-N ribitol Chemical compound OC[C@H](O)[C@H](O)[C@H](O)CO HEBKCHPVOIAQTA-ZXFHETKHSA-N 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 235000017709 saponins Nutrition 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 210000000779 thoracic wall Anatomy 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 229940126673 western medicines Drugs 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Insects & Arthropods (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a traditional Chinese medicine formula for ventilating lung and allaying fever, which is characterized in that: the traditional Chinese medicine composition comprises, by weight, 3-13 parts of honeysuckle, 1-8 parts of ephedra, 3-13 parts of almond, 12-27 parts of gypsum, 3-13 parts of fructus forsythiae, 3-13 parts of radix curcumae, 3-13 parts of stiff silkworm, 3-13 parts of radix bupleuri, 3-13 parts of radix puerariae and 2-7 parts of liquorice. The traditional Chinese medicine formula disclosed by the invention has the advantages that the compatibility of the traditional Chinese medicine accords with the principle of monarch, minister, assistant and guide of the traditional Chinese medicine, the number of the medicines is small, the pure traditional Chinese medicine is adopted for treating the infantile pneumonia, the traditional Chinese medicine has a good clinical curative effect, no toxic or side effect exists, the use of antibiotics for infants with pneumonia can be obviously reduced, and the toxic or side effect of western antibacterial medicines is avoided.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine formulas, and particularly relates to a traditional Chinese medicine formula for ventilating the lung and reducing fever.
Background
Pneumonia is one of common respiratory diseases of children, is also the most common cause of hospitalization of children, and is the leading cause of death of children under the age of 5 years old. Infantile pneumonia can occur all the year round, but is common in alternate seasons and seasons, and mainly has symptoms of fever, cough, dyspnea, chest wall air-absorbing depression and fixed moist rale of lung, and serious cases can involve nerves, circulation and digestive system to cause corresponding diseases. The children pneumonia is caused by various pathogens, bacteria, viruses, mycoplasma, chlamydia and the like are common, the treatment mainly comprises the application of antibiotics and western antiviral drugs, the application of the antibiotics is unreasonable and standard at present, the pathogenic bacteria resistance rate is obviously increased, the western antiviral drugs with definite curative effects are fewer, the specificity is lacked, and meanwhile the western antibacterial drugs have certain toxic and side effects.
Disclosure of Invention
In view of the above, the invention aims to provide a traditional Chinese medicine formula for ventilating the lung and reducing fever, which overcomes the defects of the prior art, has obvious curative effect and little side effect, and can supplement western medicines.
In order to achieve the purpose, the technical scheme of the invention is realized as follows:
a traditional Chinese medicine formula for dispersing lung qi and reducing fever comprises, by weight, 3-13 parts of honeysuckle, 1-8 parts of ephedra, 3-13 parts of almond, 12-27 parts of gypsum, 3-13 parts of fructus forsythiae, 3-13 parts of radix curcumae, 3-13 parts of stiff silkworm, 3-13 parts of radix bupleuri, 3-13 parts of radix puerariae and 2-7 parts of liquorice.
Preferably, the traditional Chinese medicine composition comprises, by weight, 6-10 parts of honeysuckle, 3-6 parts of ephedra, 6-10 parts of almond, 15-25 parts of gypsum, 6-10 parts of fructus forsythiae, 6-10 parts of radix curcumae, 6-10 parts of stiff silkworm, 6-10 parts of radix bupleuri, 6-10 parts of radix puerariae and 3-6 parts of liquorice.
Preferably, the traditional Chinese medicine composition comprises, by weight, 8 parts of honeysuckle, 4 parts of ephedra, 8 parts of almond, 20 parts of gypsum, 8 parts of fructus forsythiae, 8 parts of radix curcumae, 8 parts of stiff silkworm, 8 parts of radix bupleuri, 8 parts of radix puerariae and 5 parts of liquorice.
The invention also provides a method for preparing the traditional Chinese medicine formula for ventilating the lung and reducing fever, which comprises the following steps,
(1) putting the components into a decocting container;
(2) adding water in an amount which is 5-8 times of the weight of the non-mineral medicines, and soaking for 20-40 min;
(3) boiling with strong fire, decocting with slow fire for 30 min, filtering with filter screen with pore diameter less than 0.5mm, and collecting filtrate.
The invention also provides application of the lung ventilating and fever abating traditional Chinese medicine formula in medicines for treating infantile pneumonia or bronchitis.
Honeysuckle flower, flos Lonicerae, sweet in nature and cold in nature, is fragrant, sweet in nature and cold in nature, clears heat without hurting stomach, and is fragrant and capable of eliminating pathogenic factors. The honeysuckle can disperse wind-heat and clear away blood toxin, and has obvious effect on various heat diseases such as fever, eruption, macula, sore and carbuncle due to heat toxin, sore throat and the like. The honeysuckle contains chlorogenic acid, luteolin glycoside and other pharmacological active ingredients, and has strong inhibitory effect on hemolytic streptococcus, staphylococcus aureus and other pathogenic bacteria, upper respiratory infection pathogenic viruses and the like.
Ma Huang is pungent, slightly bitter and warm. It enters lung and bladder meridians. Induce sweating and dispel cold, ventilate lung and relieve dyspnea, induce diuresis to alleviate edema.
Almond, sweet and bitter in taste, has the actions of relieving cough and asthma and relaxing bowel, and can be used for treating diseases such as lung disease and cough.
Gypsum, Gypsum Fibrosum, is indicated for apoplexy with chills and fever, and has the functions of relieving muscles and sweating, removing dry mouth and tongue, headache and toothache, etc. Among them, sulfur and oxygen contained in the herb can be dissipated by cooling, and has the action of expelling pathogenic factors from the exterior and muscles, and the external sensation of excess heat.
Fructus forsythiae has effects in clearing away heat and toxic materials, relieving swelling, dispersing pathogen accumulation, relieving inflammation, inhibiting bacteria, and inhibiting viruses.
Radix Curcumae, pungent and bitter with the action of cooling, enters heart, lung and liver meridians, and has the effects of promoting qi circulation, relieving depression, cooling blood and removing blood stasis.
Bombyx Batryticatus has the effects of dispelling pathogenic wind, relieving spasm, dissipating phlegm and resolving masses, and is clinically used for treating tangible masses such as nodules, sore throat, scrofula, urticaria of wind sores and the like.
Radix bupleuri, being bitter and pungent in flavor and slightly cold in nature, enters liver and gallbladder meridians and has the effects of relieving exterior syndrome, relieving fever, soothing liver, relieving depression and lifting yang qi. Pharmacological research shows that the main component of bupleurum contains saikoside, and then contains phytosterol, adonitol, and a small amount of volatile oil and polysaccharide; the aerial parts mainly contain flavonoid, small amount of saponins, coumarins, lignans, etc. Has antibacterial, antiinflammatory, antiviral, antipyretic, immunity regulating, antitumor, blood lipid reducing, and liver protecting effects. Bupleurum root, radix bupleuri can strengthen the actions of relieving exterior syndrome, relieving fever, and lifting the qi of spleen and stomach to clear yang.
Kudzu root, sweet, pungent and cool. Has the functions of expelling pathogenic factors from muscles, allaying fever, promoting eruption, promoting the production of body fluid to quench thirst, invigorating yang and stopping diarrhea.
Licorice root, radix Glycyrrhizae is sweet in flavor and neutral in nature, and enters heart, lung, spleen and stomach meridians.
The pharmacological analysis of the invention: in the recipe, Ma Huang is lung-ventilating to disperse the cold on the exterior; the almond kernel is supplemented with the ephedra to ventilate the lung and play the role of lowering adverse qi to relieve cough; gypsum Fibrosum has effects of clearing lung-heat and clearing heat in the interior; the honeysuckle and the weeping forsythia disperse wind-heat, clear away heat and toxic material, avoid dirt and remove turbid; radix Curcumae and Bombyx Batryticatus have effects of promoting blood circulation, dispelling blood stasis, promoting qi circulation, and dredging collaterals; radix bupleuri and radix puerariae have the effects of relieving muscles and clearing heat; the liquorice can regulate the medicine property and also can help gypsum to promote the production of body fluid. The whole formula has the effects of freeing lung, clearing heat, removing blood stasis and dredging collaterals.
The invention is mainly used for treating diseases, such as infantile pneumonia or bronchitis, with symptoms of fever, cough, expectoration, red throat, red tongue, thin and yellow or yellow fur, rapid pulse and loose stool.
Compared with the prior art, the lung ventilating and fever abating traditional Chinese medicine formula disclosed by the invention has the following advantages:
the traditional Chinese medicine formula disclosed by the invention has the advantages that the compatibility of the traditional Chinese medicine accords with the principle of monarch, minister, assistant and guide of the traditional Chinese medicine, the number of the medicines is small, the pure traditional Chinese medicine is adopted for treating the infantile pneumonia, the traditional Chinese medicine has a good clinical curative effect, no toxic or side effect exists, the use of antibiotics for infants with pneumonia can be obviously reduced, and the toxic or side effect of western antibacterial medicines is avoided.
Drawings
FIG. 1 is a comparison of time to complete annealing KM curve.
Detailed Description
Unless defined otherwise, technical terms used in the following examples have the same meanings as commonly understood by one of ordinary skill in the art to which the present invention belongs. The test reagents used in the following examples, unless otherwise specified, are all conventional biochemical reagents; the experimental methods are conventional methods unless otherwise specified.
The present invention will be described in detail with reference to examples.
The traditional Chinese medicine formula for dispersing lung qi and bringing down fever used in the following treatment groups comprises, by weight, 8 parts of honeysuckle, 4 parts of ephedra, 8 parts of almond, 20 parts of gypsum, 8 parts of fructus forsythiae, 8 parts of radix curcumae, 8 parts of stiff silkworm, 8 parts of radix bupleuri, 8 parts of radix puerariae and 5 parts of liquorice. 1 part is 1 g.
450 children with bronchopneumonia wind-heat lung block syndrome in a pediatric ward of a first subsidiary hospital of Tianjin Chinese medicine university from 2016 to 2017 are collected. Random number tables were generated using SAS 9.1.3 and divided into 36 treatment groups and 35 control groups.
The treatment groups were 16 men and 20 women; 9 cases aged 0-1, 15 cases aged 1+ -2, 12 cases aged 2+ -3; the fever course before admission is less than or equal to 24h 14 cases and 24+ to 48h 22 cases;
control group 17 men and 18 women; 9 cases aged 0-1, 14 cases aged 1+ -2, 12 cases aged 2+ -3; the fever course before admission is less than or equal to 24h 16 cases and 24+ to 48h 19 cases. The general data comparison of two groups of patients has no statistical significance (P is more than 0.05) and is comparable.
1. Diagnostic criteria
1.1.1 Western diagnostic standards for pediatric bronchopneumonia
Reference is made to the scheme for preventing and treating four diseases in children, the scheme for preventing and treating pneumonia in children, and the 7 th edition of the Utility of Chinese flowering crabapple of China.
(1) General symptoms: the acute or delayed onset of the disease can be accompanied by symptoms such as fever, food refusal, emesis, lethargy, dysphoria, asthma, etc.
(2) Symptoms and signs of the respiratory system: cough and throat sputum, rapid respiration, frequent dyspnea, groan on expiration, nasal flaring, trismus, perioral or nail cyanosis. The early signs of the chest can be unobvious, then middle and coarse humors can be heard, and after several days, fine humors or twitch sounds can be heard; or tubular breath sounds can be heard.
(3) Chest radiography: it can be expressed as nonspecific small-spot sheet-like lung parenchyma infiltration shadow, and the two lungs have more lower wild, heart diaphragm corner area and middle and inner zone, and can be partially fused into large-sheet-like infiltration shadow.
(4) Blood picture: white blood cell count can be reduced, normal or slightly increased.
1.1.2 Chinese medicine diagnosis of pneumonia, dyspnea and cough
(1) Disease diagnosis
According to the diagnosis basis of pneumonia, asthma and cough in the 'standard of curative effect for diagnosing pediatric diseases of traditional Chinese medicine' of the State administration of traditional Chinese medicine.
a. Acute onset with fever, cough, shortness of breath, nasal flaring, wheezy phlegm, etc., or mild cyanosis.
b. In severe cases, dyspnea with restlessness, pale complexion, cyanosis with aggravation, or persistent hyperpyrexia.
c. The infant is usually suffered from congenital deficiency and the course of disease is prolonged.
d. Auscultation of lung, middle and thin moist rales, often accompanied by rales or tubular breath sounds.
e. Blood picture: white blood cell counts may be reduced, slightly increased or normal.
f. Chest radiography: the lung shows increased texture, disorder, and reduced transparency, or is in the form of small, spotted, fuzzy shadows, or uneven large shadows.
(2) Syndrome diagnosis
According to the wind-heat lung-blocking syndrome classification standard of pneumonia, asthma and cough in the national traditional Chinese medicine administration 'Standard of curative Effect for diagnosis of disease of traditional Chinese medicine, Standard of curative Effect for diagnosis of pediatric disease of traditional Chinese medicine'.
Pattern of wind-heat blocking the lung: fever with aversion to wind, slight sweating, thirst with desire for water, cough, thick and yellow sputum, shortness of breath and red throat. A red tongue tip, thin and yellow coating and a superficial and rapid pulse.
1.1.3 Chinese medicine syndrome scoring standard
Refer to the national institute of traditional Chinese medicine "guidelines for clinical research of new drugs".
1.2 inclusion criteria
(1) According with the diagnosis standard, the lung blockage syndrome caused by wind heat of bronchopneumonia is confirmed;
(2) the course of pneumonia does not exceed 48 hours;
(3) the maximum body temperature is more than or equal to 38.5 ℃ within 24 hours before the group is added;
(4) the age is 3-6 years old; the weight is more than or equal to 14 kg;
(5) the number of white blood cells is less than or equal to 10 multiplied by 109/L, and the proportion of neutral granulocytes is less than 70 percent;
(6) c-reactive protein: normal;
(7) hospitalized patients;
(8) the legal guardian of the sick child gives informed consent and signs an informed consent form;
1.3 criteria for excluded cases
(1) When the medicine is selected, patients with heart failure, respiratory failure, toxic encephalopathy, exudative pleurisy and other complications are present.
(2) Bacterial infections were specifically combined at enrollment.
(3) When the selection is performed, serious primary diseases such as heart, liver, kidney and hematopoietic system and the like are combined.
(4) At the discretion of the investigator, there are other lesions that reduce the likelihood of or complicate enrollment.
(5) The infant patient is unable to collaborate or is participating in clinical trials with other medications.
(6) Allergic constitution (allergic to more than two kinds of substances) or allergic to known components of the preparation.
(7) According to the judgment of doctors, the patients are easy to lose visit.
2 method
2.1 methods of treatment
Both groups of children were administered cefuroxime sodium (West Lixin, 0.75 g/ramus, lot No. m869, Kurarin Schker) 80 mg/(kg. d) to the clinically considered bacterial infected patients according to "guidelines for community-acquired pneumonia" 5, and 5% glucose injection was added for intravenous drip 2 times a day; or intravenous drip of ceftriaxone (Rogofen, 1 g/tube, batch number: SH1612, Shanghai Roche pharmaceutical Co., Ltd.) 80 mg/(kg. d), adding 5% glucose injection, and intravenous drip for 1 time per day. Clinical considerations A mycoplasma infected person was administered azithromycin (Shsumei, 0.5 g/ramus, Perey pharmaceutical Co., Ltd.) in an amount of 10 mg/(kg. d) by intravenous drip with 5% glucose injection 1 time a day for 5 days.
The treatment group is added with the Jinhuang antipyretic prescription, 1 dose per day and is orally taken for 3 times. Both groups were treated for 7 days.
2.2 Observation indicators and methods
2.2.1 therapeutic index
The clinical cure is as follows: firstly, fine wet rale disappears in lung auscultation; secondly, complete defervescence; thirdly, the dyspnea disappears; fourthly, cough and phlegm are reduced to I level and below.
The disease is not cured: those who do not meet the clinical recovery standard.
Note: the evaluation of the cough and phlegm congestion degree I grade is referred to the standard of '2 points in the Chinese medicine syndrome point grading quantitative standard table'.
(2) Complete defervescence time: after taking the medicine, the body temperature returns to normal (less than or equal to 37.2 ℃) and is maintained for more than 24 hours.
(3) Evaluation standard of traditional Chinese medicine syndrome curative effect
And (3) healing: the reduction rate of the syndrome score and (including the tongue pulse score) is more than or equal to 90 percent.
The effect is shown: the syndrome score is more than or equal to 67 percent and the reduction rate is less than 90 percent.
The improvement is as follows: the syndrome score is more than or equal to 33 percent and the reduction rate is less than 67 percent.
And (4) invalidation: syndrome score and reduction rate < 33%.
Note: the syndrome score is equal to fever, cough, phlegm accumulation, dyspnea, secondary symptoms (thirst, dry stool, yellow urine) and tongue coating pulse.
(4) Evaluating the curative effect of single symptom index: the treatment effect of the disease is evaluated according to the single indexes (cough, phlegm accumulation and dyspnea and tachypnea).
And (3) healing: the symptoms disappear after treatment.
The effect is shown: after treatment, the symptoms are graded by 2 grades from severe to mild.
The method has the following advantages: after treatment, the symptoms are graded by 1 grade, namely from severe to moderate, or from moderate to mild.
And (4) invalidation: there was no change before and after treatment.
2.2.2 safety indices two groups of infants were examined for blood routine, urine routine, stool routine, electrocardiogram and liver and kidney function indices before and after treatment.
2.3 Standard of the treatment Effect of TCM syndrome
According to the technical points of clinical research on traditional Chinese medicine in paediatrics diseases, the recovery rate is that the reduction rate of syndrome integral sum (including tongue pulse value) is more than or equal to 90 percent; the obvious effect is that the syndrome integral is more than or equal to 70 percent and the reduction rate is less than 90 percent; effective, the integral of the syndrome is more than or equal to 30 percent, and the reduction rate is less than 70 percent; the failure rate of the syndrome integration and reduction rate is less than 30 percent. The cure rate is (number of cure cases + number of significant cases + number of effective cases)/total number of cases × 100%.
2.4 statistical methods
SPSS 17.0 statistical software was used. Qualitative data is described in terms of frequency tables, percentages or composition ratios; quantitative data are described as mean ± standard deviation. Adopting X2 test for qualitative data; quantitative data were tested using a t-test, and hypothesis testing was performed using a two-sided test in unison.
3 results
3.1 test control group infant basic data
The demographic data (sex, ethnicity, age, height, weight), pneumonia course, etc. of the subjects before treatment are compared among groups, and the differences have no significant meaning (P is more than 0.05) and are comparable.
TABLE 1 comparison of basic data of children patients
3.2 baseline data for disease symptoms in control group of infants
The related indexes of the curative effect comprise the sum of the main symptoms, the traditional Chinese medicine syndrome score and the scores of single symptoms (fever, cough, dyspnea, phlegm congestion and the like), and the comparative difference among the indexes has no significant statistical significance (P is more than 0.05), and has comparability (shown in a table 2).
TABLE 2 comparison of disease symptom data of children patients
3.2 results of the study
3.2.1 comparison of therapeutic efficacy of diseases
3.2.1.1 comparison of efficacy of disease treatment in control group on day 7 of treatment and at the end of treatment
On day 7 of treatment, the treatment group had a recovery rate (recovery + significant) of 41.67% and the control group was 17.14% (table 3); the treatment group showed 80.56% more significant and 45.71% more significant at the end of treatment (table 4). The analysis results of the curative effect grade and the healing rate on the 7 th day of treatment and at the end of treatment show that the two groups of differences have significant statistical significance (P is less than 0.05), and the curative effect of the disease in the treatment group is better than that in the control group in combination with clinic.
TABLE 3 therapeutic Effect on day 7 disease
TABLE 4 therapeutic effects on diseases at the end of treatment
3.2.2 comparison of the therapeutic effects of the syndromes of traditional Chinese medicine
3.2.2.1 comparison of the curative effects of the TCM syndrome at the 7 th day of treatment and at the end of the treatment in the control group
On the 7 th day of treatment, the treatment group with the rate of the traditional Chinese medicine syndrome curative effect becoming more significant was 50.0%, and the control group was 28.57% (table 5); the treatment group with the rate of the treatment becoming more significant than the treatment effect of the syndrome of traditional Chinese medicine at the end of the treatment was 94.44%, and the control group was 71.43% (table 6). The analysis results of the curative effect grade and the healing rate of 7 days and 10 days after treatment show that the two groups of differences have significant statistical significance (P is less than 0.05), and the curative effect of the syndrome of the treatment group is better than that of the control group in combination with clinic.
TABLE 5 curative effects on syndrome of TCM on day 7
TABLE 6 curative effects of the Chinese medicine syndrome at the end of the treatment
3.2.3 evaluation of the efficacy of Individual symptoms
3.2.3.1 comparison of the rate of increasing fever
At the end of treatment, all children with fever symptoms are cured clinically (fever symptoms disappear), so that the improvement on fever symptoms is realized, and no significant difference exists between a treatment group and a control group. (Table 7)
TABLE 7 comparison of the heat generation increasing rates
3.2.3.2 comparison of the prevalence of cough
The curative rate of cough symptom curative effect of the 2 groups is 72.22% of the treatment group and 40.0% of the control group respectively, the difference of the two groups has significance statistical significance (P is less than 0.05), and the curative effect of cough symptom curative effect of the treatment group is better than that of the control group. (Table 8)
TABLE 8 comparison of the rate of progression of cough
3.2.3.3 comparison of the rate of increasing phlegm accumulation
The curative effect of the phlegm obstruction symptoms of the 2 groups is respectively 75.0 percent of that of the treatment group and 31.43 percent of that of the control group, the difference of the two groups has significant statistical significance (P is less than 0.05), and the curative effect of the phlegm obstruction symptoms of the treatment group is better than that of the control group. (watch 9)
TABLE 9 comparison of the curative ratio of phlegm accumulation
3.2.3.4 comparison of the incidence of wheezing
Since some of the infants did not show tachypnea at the time of onset, 25 of the 71 infants collected showed tachypnea, and the treatment groups showed no significant difference from the control group in the rate at which the therapeutic effect of the tachypnea became more significant at the end of the treatment. (watch 10)
TABLE 10 comparison of the incidence of dyspnea
3.2.4 comparison of complete antipyretic time of control group
The two groups had complete antipyretic time, median time of the treatment group was 0.5 days, that of the control group was 1.0 day, and the median time of the treatment group was shorter than that of the control group. KM profile of complete antipyretic time for both groups of whole subjects. The Log-Rank test results of the complete antipyretic time of the two groups show that the difference has significant statistical significance (P is less than 0.05). (shown in FIG. 1)
3.2.5 Security analysis
In the treatment process, the two groups of medicines have better compliance, and no adverse event occurs. (watch 11)
TABLE 11 degree of drug administration and adverse events
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (5)
1. A lung ventilating and fever abating traditional Chinese medicine composition for treating infantile pneumonia or bronchitis is characterized in that: the traditional Chinese medicine composition comprises, by weight, 3-13 parts of honeysuckle, 1-8 parts of ephedra, 3-13 parts of almond, 12-27 parts of gypsum, 3-13 parts of fructus forsythiae, 3-13 parts of radix curcumae, 3-13 parts of stiff silkworm, 3-13 parts of radix bupleuri, 3-13 parts of radix puerariae and 2-7 parts of liquorice.
2. The lung ventilating and fever abating traditional Chinese medicine composition for treating infantile pneumonia or bronchitis according to claim 1, which is characterized in that: the traditional Chinese medicine composition comprises, by weight, 6-10 parts of honeysuckle, 3-6 parts of ephedra, 6-10 parts of almond, 15-25 parts of gypsum, 6-10 parts of fructus forsythiae, 6-10 parts of radix curcumae, 6-10 parts of stiff silkworm, 6-10 parts of radix bupleuri, 6-10 parts of radix puerariae and 3-6 parts of liquorice.
3. The lung ventilating and fever abating traditional Chinese medicine composition for treating infantile pneumonia or bronchitis according to claim 1, which is characterized in that: the traditional Chinese medicine composition comprises, by weight, 8 parts of honeysuckle, 4 parts of ephedra, 8 parts of almond, 20 parts of gypsum, 8 parts of fructus forsythiae, 8 parts of radix curcumae, 8 parts of stiff silkworm, 8 parts of radix bupleuri, 8 parts of radix puerariae and 5 parts of liquorice.
4. A method for preparing the lung-ventilating and fever-abating traditional Chinese medicine composition for treating infantile pneumonia or bronchitis according to any one of claims 1 to 3, which is characterized by comprising the following steps: comprises the following steps of (a) carrying out,
(1) putting the components into a decocting container;
(2) adding water in an amount which is 5-8 times of the weight of the non-mineral medicines, and soaking for 20-40 min;
(3) boiling with strong fire, decocting with slow fire for 30 min, filtering with filter screen with pore diameter less than 0.5mm, and collecting filtrate.
5. The application of the lung ventilating and fever abating traditional Chinese medicine composition as claimed in any one of claims 1 to 3 in preparing a medicine for treating infantile pneumonia or bronchitis.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810211552.5A CN108355106B (en) | 2018-03-14 | 2018-03-14 | Traditional Chinese medicine formula for ventilating lung and abating fever |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810211552.5A CN108355106B (en) | 2018-03-14 | 2018-03-14 | Traditional Chinese medicine formula for ventilating lung and abating fever |
Publications (2)
Publication Number | Publication Date |
---|---|
CN108355106A CN108355106A (en) | 2018-08-03 |
CN108355106B true CN108355106B (en) | 2021-02-05 |
Family
ID=63000288
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201810211552.5A Expired - Fee Related CN108355106B (en) | 2018-03-14 | 2018-03-14 | Traditional Chinese medicine formula for ventilating lung and abating fever |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN108355106B (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101015616A (en) * | 2007-03-02 | 2007-08-15 | 河北(冀衡集团)华威制药有限公司 | Chinese medicine composition for treating children pneumonia and preparing method thereof |
CN103070945A (en) * | 2013-02-18 | 2013-05-01 | 李承平 | Ephedra forsythia tablet |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104013864A (en) * | 2014-05-20 | 2014-09-03 | 王伟伟 | Traditional Chinese medicine composition for treating bronchitis |
-
2018
- 2018-03-14 CN CN201810211552.5A patent/CN108355106B/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101015616A (en) * | 2007-03-02 | 2007-08-15 | 河北(冀衡集团)华威制药有限公司 | Chinese medicine composition for treating children pneumonia and preparing method thereof |
CN103070945A (en) * | 2013-02-18 | 2013-05-01 | 李承平 | Ephedra forsythia tablet |
Also Published As
Publication number | Publication date |
---|---|
CN108355106A (en) | 2018-08-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102657805B (en) | Loquat scented tea and preparation technology thereof | |
CN102940832B (en) | Medicament for treating chronic bronchitis and preparation method thereof | |
CN103211997B (en) | Antibacterial and antiviral traditional Chinese medicine composition and preparation method thereof | |
CN1843499A (en) | Traditional Chinese medicine formulation for treating bronchitis and tonsillitis | |
CN103212006A (en) | Traditional Chinese medicine for treating chronic bronchitis | |
CN101474377B (en) | Chinese medicine prescription for treating chronic bronchitis | |
CN112870268A (en) | Medicine for treating acute suppurative tonsillitis of children | |
CN109157574B (en) | Traditional Chinese medicine composition for oral care of critically ill patients and oral care solution containing traditional Chinese medicine composition | |
CN108355106B (en) | Traditional Chinese medicine formula for ventilating lung and abating fever | |
CN105497723A (en) | Traditional Chinese medicine preparation for treating bacterial pneumonia and preparation method thereof | |
CN103142733B (en) | Chinese medicine composition for treating upper respiratory infection | |
CN113559205B (en) | Traditional Chinese medicine composition for treating infantile common cold and application | |
CN104306793A (en) | Chinese herba preparation for treating lobar pneumonia | |
CN102949516A (en) | Health-care product lozenge for pharyngitis and preparation method thereof | |
CN103463400B (en) | Chinese medicine composition for treating infantile asthma | |
CN102205037B (en) | Oral medicinal composition for treating infantile bronchitis caused by bacterial infection and preparation method thereof | |
CN104288681A (en) | Traditional Chinese medicine composition for treating children virus pneumonia | |
CN104721388B (en) | The Chinese medicine composition and its preparation method and application for treating people at highest risk's influenza severe | |
CN115252724B (en) | Traditional Chinese medicine composition for treating pharyngitis, product and preparation method | |
CN103463401B (en) | Asthma medicine for infants | |
CN116966232B (en) | Traditional Chinese medicine composition for treating phlegm-heat accumulated lung syndrome community-acquired pneumonia and application thereof | |
CN108653552B (en) | Traditional Chinese medicine for clearing lung and relieving cough | |
Hua et al. | Combination of Qingfei Huayu Decoction and Targeted Nursing Care Improves the Clinical Outcomes in Pediatric Patients with Mycoplasma Pneumoniae Pneumonia | |
CN105168638A (en) | Traditional Chinese medicinal liquid band aid for preventing and treating bedsore complicated with bacterial infection | |
CN103041266B (en) | Medicine for treating pediatric postoperative pneumonia |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20210205 |
|
CF01 | Termination of patent right due to non-payment of annual fee |