CN102949516A - Health-care product lozenge for pharyngitis and preparation method thereof - Google Patents
Health-care product lozenge for pharyngitis and preparation method thereof Download PDFInfo
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- CN102949516A CN102949516A CN 201210455194 CN201210455194A CN102949516A CN 102949516 A CN102949516 A CN 102949516A CN 201210455194 CN201210455194 CN 201210455194 CN 201210455194 A CN201210455194 A CN 201210455194A CN 102949516 A CN102949516 A CN 102949516A
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Abstract
The invention discloses a health-care product lozenge for pharyngitis and a preparation method thereof. The health-care product lozenge for the pharyngitis comprises the following components by weight part: 20 parts of honeysuckle extractives, 20 parts of fructus forsythiae extractives, 20 parts of scaphium scaphigerum extractives, 15 parts of chrysanthemum extractives, 10 parts of tenuifolia extractives, 10 parts of caulis perllae extractives, 15 parts of scutellaria baicalensis extractives, 20 parts of radix scrophulariae extractives, 75 parts of taurine, 68 parts of mannitol, 48 parts of aspartame, 72 parts of menthol and 12 parts of magnesium stearate. The health-care product lozenge for the pharyngitis provided by the invention is a lozenge composed of pure traditional Chinese medicine ingredients, has the effects of nourishing yin and removing heat as well as relieving sore-throat and relieving pain, and is suitable for chronic pharyngitis patients who suffer dry throat, scorching and pain, dry tickle and dumbness, dry mouth and tongue or bucking. Meanwhile, the health-care product lozenge for the pharyngitis tastes good, is convenient to carry and take and is dependency-free. The preparation method for the health-care product lozenge for the pharyngitis provided by the invention is simple and a conventional device can be used for preparing the health-care product lozenge for the pharyngitis.
Description
Technical field
The invention belongs to the health care medicine technical field, relate to a kind of health-care product buccal tablet, particularly a kind of health-care product buccal tablet for pharyngitis and preparation method thereof.
Background technology
Pharyngitis is pharyngeal mucosa, and the inflammation of submucous tissue often is the part of upper respiratory tract infection.Different according to the length of the course of disease and pathological change character are divided into acute pharyngitis, chronic pharyngitis two large classes.
Chronic pharyngitis (Chronicpharyngitis) is mainly pharynx mucosa chronic inflammatory disease, and diffuse inflammation often is the part of chronic other property inflammation of upper respiratory tract, and the limitation inflammation is many inflammation with the pharynx lymphoid tissue then.Chronic pharyngitis is a kind of commonly encountered diseases, frequently-occurring disease clinically, and is relatively more obstinate in the Drug therapy of routine, and repeatedly outbreak, and flu increases the weight of, and is common with middle age.Show as pharyngeal mucosa chronic congestion.Pathological changes mainly concentrates on pharyngeal mucous layer, has more lymphoid tissue to infiltrate around its blood vessel, also visible leukocyte and plasmocyte infiltrating.Connective tissue proliferation under mucosa and the mucosa can be loose with mucous gland, glandular secretion hyperfunctioning, mucus secretion increasing and than thickness.Chronic pharyngitis is more common in the adult, and the child also can occur.General Symptoms is all not obvious, take local symptom as main.Various chronic pharyngitis symptom is roughly similar and varied, as pharyngeal sense of discomfort, foreign body sensation, pharyngeal secretions be difficult for bringing up, pharyngeal gargalesthesia, burn feeling, dry sensation or excitement, also the hypodynia sense can be arranged.Because the pharynx rear wall adheres to because pharyngeal chronic inflammatory disease causes than thick secretions usually, and because nose, nasal sinuses, nasopharynx pathological changes cause the mouth breathing at night, the morning time-out of being everlasting irritable cough occurs and feels sick.Because the foreign body in pharynx sense can show as frequently and swallow.Pharyngeal secretions is few and be difficult for expectoration person and often show as habitually dry cough and the action of coughing up phlegm of clearing one's throat, and can cause pharyngeal mucosa hemorrhage if firmly cough or clear one's throat, and causes and is with blood in the secretions.
The traditional Chinese medical science thinks that the pathological changes of pharyngitis is throat, but its pathology formation and lung, liver, stomach, kidney have substantial connection.Therefore pharyngitis can not be anxious for success and with the Western medicine of some anti-inflammatory types.The chronic pharyngitis etiology and pathogenesis often is that internal organs are deficient, and the consumption impairment of YIN is divided, and hyperactivity of deficient fire causes in throat, or repeatedly shows effect because of acute pharyngitis due to wind-heat, remaining evil delay the, or dust, foul smell stimulates, and the hobby tobacco and wine are pungent, impairment caused by overstrain excessively waits and causes, deficiency of lung-YIN is deficiency of body fluid then, and it is foster that throat loses in moistening, and furthermore asthenic fire is followed through upper inflammation; Deficiency of the kidney yin, network is in lung on the passages through which vital energy circulates of kidney, and deficiency of the kidney yin whenever causes the also deficiency of YIN of lung, and hyperactivity of deficient fire is satisfied to sore throat.In addition, steam on the asthenic fire, bright Tianjin becomes expectorant, in addition venation numbness resistance, and disorder of QI movement causes stagnation of QI expectorant solidifying, phlegm-fire pent-up.Throat is the door of lung stomach, such as the lung stomach intrinsic heat is arranged, and is burning hot scorching, and QI and blood is tied in throat, visible local chronic congestion, and mucosa is dry and fall ill.Other deficiency of kidney-YIN, hyperactivity of deficient fire, dry laryngopharynx, snoring can be sent out for a long time and also and is pharyngitis.
Whether can the Chinese traditional treatment method very cure pharyngitis? in current clinical medicine, using the treatment by Chinese herbs pharyngitis is take the Chinese medical discrimination theory as the basis, and take YIN nourishing increase liquid, nourishing the lung and kidney, removing heat-phlegm, the sore-throat relieving that wets one's whistle is as the primary treatment purpose.In pharyngitis patient's clinical treatment, the treatment by Chinese herbs method has progressively represented powerful development potentiality.At present, now the kind of various health care medicines is a lot of on the market, but has replenishing YIN and removing heat, relieving sore throat and pain, alleviates dry laryngopharynx, scorching hot pain, the dried hoarseness of itching, dry mouth and parching tongue or cough the health care medicine of this comprehensive nourishing and therapeutic efficiency with choking few; Even the efficiency health-care medicine that has some to have this comprehensive nourishing and treatment, but be not pure Chinese medicinal preparation, simultaneously mouthfeel bad, carry and take inconvenience.
Summary of the invention
Purpose of the present invention aims to provide a kind of health-care product buccal tablet for pharyngitis and preparation method thereof, the health-care product buccal tablet that should be used for pharyngitis is the buccal tablet that a kind of pure Chinese medicinal ingredients forms, it has replenishing YIN and removing heat, relieving sore throat and pain, alleviation dry laryngopharynx, scorching hot pain, the dried hoarseness of itching, dry mouth and parching tongue or the effect of coughing with choking; Simultaneously, its mouthfeel is good, onset rapid, carry taking convenience, no dependence.
Technical scheme of the present invention is: design a kind of health-care product buccal tablet for pharyngitis, it is characterized in that composition and weight proportion thereof that it contains are: 20 parts of Flos Lonicerae extracts, 20 parts of Fructus Forsythiae extracts, 20 parts of Semen Sterculiae Lychnophorae extracts, 15 parts of Flos Chrysanthemi extracts, 10 parts of Herba Schizonepetae extracts, 10 parts of Caulis Perillae extracts, 15 parts of Radix Scutellariae extracts, 20 parts of first conopsea extractions, 75 parts of taurines, 68 parts in mannitol, 48 parts of aspartames, 72 parts of Mentholums, 12 parts of magnesium stearate.
The preparation method of described a kind of health-care product buccal tablet for pharyngitis is characterized in that it may further comprise the steps:
1) takes by weighing raw material by following weight ratio: 20 parts of Flos Lonicerae extracts, 20 parts of Fructus Forsythiae extracts, 20 parts of Semen Sterculiae Lychnophorae extracts, 15 parts of Flos Chrysanthemi extracts, 10 parts of Herba Schizonepetae extracts, 10 parts of Caulis Perillae extracts, 15 parts of Radix Scutellariae extracts, 20 parts of first conopsea extractions, 75 parts of taurines, 68 parts in mannitol, 48 parts of aspartames, 72 parts of Mentholums, 12 parts of magnesium stearate;
2) above-mentioned recipe quantity Flos Lonicerae extract, Fructus Forsythiae extract, Semen Sterculiae Lychnophorae extract, Flos Chrysanthemi extract, Herba Schizonepetae extract, Caulis Perillae extract, Radix Scutellariae extract, first conopsea extraction, taurine, mannitol, aspartame are crossed respectively 100 mesh sieves, mix homogeneously sieves.
3) with said mixture with 85% ethanol soft material processed, soft material is granulated with 16 mesh sieves;
4) will make 55 ℃ of forced air dryings of granule 25 minutes;
5) take by weighing above-mentioned recipe quantity Mentholum and be dissolved in the dehydrated alcohol, for subsequent use;
6) get the dried particles of half step 3, the Mentholum alcoholic solution evenly be sprayed on the dried particles, 40 ℃ dry 5-10 minute;
7) with the granule of second half dried particles of step 4 and step 6, add above-mentioned recipe quantity magnesium stearate mix homogeneously, 16 mesh sieve granulate;
8) tabletting gets final product.
Advantage of the present invention is: the health-care product buccal tablet for pharyngitis of the present invention has replenishing YIN and removing heat, relieving sore throat and pain, alleviation dry laryngopharynx, scorching hot pain, the dried hoarseness of itching, dry mouth and parching tongue or the effect of coughing with choking; This invention forms in conjunction with the modern Chinese medicine theory according to the Chinese medicine principles of formulating prescriptions, wherein the monarch drug Flos Lonicerae extract has effect antibiotic and the enhancing immunologic function in the prescription, and test shows that Flos Lonicerae all has inhibitory action to Bacillus typhi, Salmonella paratyphi, escherichia coli, Bacillus proteus, bacillus pyocyaneus, bordetella pertussis, vibrio cholera, staphylococcus, streptococcus, Diplococcus pneumoniae, meningococcus etc.Fructus Forsythiae extract has the town to be told, anti-liver injury treatment hepatitis, the effects such as heart tonifying, diuresis.The diseases such as the acute anemopyretic cold of forsythia fruit for treating commonly used, carbuncle sore tumefacting virus, tuberculous lymphadenitis, urinary tract infection.Semen Sterculiae Lychnophorae extract has clearing heat and moistening lung, liyan jiedu, the effect of loosening bowel to relieve constipation.Be used for the lung-heat celostomia, dry cough without phlegm, pharyngodynia with dryness, accumulation of heat just closes, the headache conjunctival congestion.Flos Chrysanthemi extract cures mainly loose wind heat clearing away, and suppressing the hyperactive liver makes eye bright.Be used for anemopyretic cold, have a headache dizzy, conjunctival congestion and swelling pain, eyes is dim-sighted.The Herba Schizonepetae extract experiment in vitro proves, the Herba Schizonepetae decoct has stronger antibacterial action to staphylococcus aureus and diphtheria corynebacterium. in addition, anthrax bacillus, group B streptococcus, Bacillus typhi, dysentery bacterium, bacillus pyocyaneus and Bacillus tuberculosis etc. there are certain inhibitory action. Herba Schizonepetae decoct and Herba Schizonepetae mix decoct with Radix Saposhnikoviae all has obvious inhibition mice auricle swelling effect, mixes decoct and fries in shallow oil effective than singly. and the inflammation that the Herba Schizonepetae Dichlorodiphenyl Acetate causes has obvious antiinflammatory action.Taurine has strong liver function of gallbladder promoting, analgesic, antiinflammatory, blood pressure lowering, hypoglycemic effect.Simultaneously, it is pure Chinese medicinal preparation, and mouthfeel is good, onset is rapid, carry taking convenience, no dependence.The preparation method of the health-care product buccal tablet for pharyngitis of the present invention is simple, and conventional equipment just can prepare to be finished.
The specific embodiment
The invention will be further described below in conjunction with specific embodiment, but not as limitation of the present invention.The part that is not described in detail in the present embodiment is to adopt prior art, and industry standard or known approaches.
Embodiment 1
Health-care product buccal tablet that is used for pharyngitis and preparation method thereof adopts following steps to make:
1) takes by weighing raw material by following weight ratio: 20 parts of Flos Lonicerae extracts, 20 parts of Fructus Forsythiae extracts, 20 parts of Semen Sterculiae Lychnophorae extracts, 15 parts of Flos Chrysanthemi extracts, 10 parts of Herba Schizonepetae extracts, 10 parts of Caulis Perillae extracts, 15 parts of Radix Scutellariae extracts, 20 parts of first conopsea extractions, 75 parts of taurines, 68 parts in mannitol, 48 parts of aspartames, 72 parts of Mentholums, 12 parts of magnesium stearate;
2) above-mentioned recipe quantity Flos Lonicerae extract, Fructus Forsythiae extract, Semen Sterculiae Lychnophorae extract, Flos Chrysanthemi extract, Herba Schizonepetae extract, Caulis Perillae extract, Radix Scutellariae extract, first conopsea extraction, taurine, mannitol, aspartame are crossed respectively 100 mesh sieves, mix homogeneously sieves.
3) with said mixture with 85% ethanol soft material processed, soft material is granulated with 16 mesh sieves;
4) will make 55 ℃ of forced air dryings of granule 25 minutes;
5) take by weighing above-mentioned recipe quantity Mentholum and be dissolved in the dehydrated alcohol, for subsequent use;
6) get the dried particles of half step 3, the Mentholum alcoholic solution evenly be sprayed on the dried particles, 40 ℃ dry 5-10 minute;
7) with the granule of second half dried particles of step 4 and step 6, add above-mentioned recipe quantity magnesium stearate mix homogeneously, 16 mesh sieve granulate;
8) tabletting gets final product.
The below be a kind of health-care product buccal tablet treatment pharyngitis for pharyngitis of the embodiment of the invention clinical observation:
1 data and method
1.1 physical data
Pharyngitis patient's 100 examples of selecting outpatient service to receive treatment voluntarily, male's 50 examples, women's 50 examples are divided into treatment group 1, treatment group 2, treatment group 3 at random, and matched group, every group of 25 examples; Each is organized the patient age symptom and consists of without significant difference disease time 1-7 days.Has comparability (P〉0.05).
1.2 Therapeutic Method
The treatment group Primary Care is consistent, and matched group is not taken medicine.The treatment group 1 usefulness embodiment of the invention 1, every day three times, an a slice, 7d is a course for the treatment of.The cydiodine of the plain pharmaceutical manufacturing for the treatment of group 2 usefulness Beijing China, each 1～2,4 times on the 1st; Treatment group 3 is used throat moistening and cleaning tablet, (Shanxi Ren Yuantang pharmaceutcal corporation, Ltd), a 4-6 sheet, 2 times on the one.
2 results
2.1 curative effect determinate standard
Recovery from illness: clinical symptom disappearance, check that red swelling of the pharynx disappears, pharynx rear wall lymph follicle recovers normal; Produce effects: transference cure, pharyngeal hyperemia alleviates, but curative effect do not consolidate, and the accidental cause Changes in weather speaks that too much flue dust stimulates and symptom slightly recurs, and the short-term medication is namely healed; Take a turn for the better: symptom is obviously improved, and irritable cough reduces, and checks that the pharyngeal inflammation that still has changes; Invalid: medication treatment state of an illness symptom is without improvement.
2.2 therapeutic outcome
| Cure | Produce effects | Take a turn for the better | Invalid | Effective percentage | |
| Contrast | ? | ? | ? | 25 | 0 |
| Treatment group 1 | 11 | 8 | 4 | 2 | 92% |
| Treatment group 2 | 9 | 8 | 5 | 5 | 80% |
| Treatment group 3 | 6 | 6 | 3 | 4 | 84% |
3 discuss
Chronic pharyngitis belongs to Chinese medicine " sore throat " category, and pathogenic factor mostly is acute pharyngitis and repeatedly shows effect, in the adjacent tissue chronic inflammatory disease be owing to the stimulation that is subjected to for a long time tobacco and wine, chemical gas, dust and excessively the reasons such as sounding, digestive disorder, rheumatic fever cause.Main manifestations is discomfort, hypodynia, foreign body sensation in the pharynx. the noise made in coughing or vomiting of often uttering a sound or a word action etc.This course of disease is touching, the Chang Fanfu outbreak.Adopt pure Chinese medicine composition diffusing lung, relieving exterior syndrome, promoting QI to circulate and dispersing the agglomeration of the pathogens, lowering the adverse-rising QI and eliminating phlegm reaches the healing purpose.And then illustrate that embodiment 1 affiliated prescription is reliably effective in this invention.
Claims (2)
1. be used for the health-care product buccal tablet of pharyngitis, it is characterized in that composition and weight proportion thereof that it contains are: 20 parts of Flos Lonicerae extracts, 20 parts of Fructus Forsythiae extracts, 20 parts of Semen Sterculiae Lychnophorae extracts, 15 parts of Flos Chrysanthemi extracts, 10 parts of Herba Schizonepetae extracts, 10 parts of Caulis Perillae extracts, 15 parts of Radix Scutellariae extracts, 20 parts of first conopsea extractions, 75 parts of taurines, 68 parts in mannitol, 48 parts of aspartames, 72 parts of Mentholums, 12 parts of magnesium stearate.
2. the preparation method of the described health-care product buccal tablet for pharyngitis of claim 1 is characterized in that it may further comprise the steps:
1) takes by weighing raw material by following weight ratio: 20 parts of Flos Lonicerae extracts, 20 parts of Fructus Forsythiae extracts, 20 parts of Semen Sterculiae Lychnophorae extracts, 15 parts of Flos Chrysanthemi extracts, 10 parts of Herba Schizonepetae extracts, 10 parts of Caulis Perillae extracts, 15 parts of Radix Scutellariae extracts, 20 parts of first conopsea extractions, 75 parts of taurines, 68 parts in mannitol, 48 parts of aspartames, 72 parts of Mentholums, 12 parts of magnesium stearate;
2) above-mentioned recipe quantity Flos Lonicerae extract, Fructus Forsythiae extract, Semen Sterculiae Lychnophorae extract, Flos Chrysanthemi extract, Herba Schizonepetae extract, Caulis Perillae extract, Radix Scutellariae extract, first conopsea extraction, taurine, mannitol, aspartame are crossed respectively 100 mesh sieves, mix homogeneously sieves;
3) with said mixture with 85% ethanol soft material processed, soft material is granulated with 16 mesh sieves;
4) will make 55 ℃ of forced air dryings of granule 25 minutes;
5) take by weighing above-mentioned recipe quantity Mentholum and be dissolved in the dehydrated alcohol, for subsequent use;
6) get the dried particles of half step 3, the Mentholum alcoholic solution evenly be sprayed on the dried particles, 40 ℃ dry 5-10 minute;
7) with the granule of second half dried particles of step 4 and step 6, add above-mentioned recipe quantity magnesium stearate mix homogeneously, 16 mesh sieve granulate;
8) tabletting gets final product.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210455194 CN102949516A (en) | 2012-11-14 | 2012-11-14 | Health-care product lozenge for pharyngitis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201210455194 CN102949516A (en) | 2012-11-14 | 2012-11-14 | Health-care product lozenge for pharyngitis and preparation method thereof |
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| CN102949516A true CN102949516A (en) | 2013-03-06 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103285230A (en) * | 2013-06-13 | 2013-09-11 | 西安新通药物研究有限公司 | Pharmaceutical composition for treating pharyngitis and preparation method thereof |
| CN106389445A (en) * | 2016-11-17 | 2017-02-15 | 郑州郑先医药科技有限公司 | Western medicine compound preparation for treating chronic pharyngitis |
| CN106421137A (en) * | 2016-11-17 | 2017-02-22 | 郑州郑先医药科技有限公司 | Compound preparation for treating chronic pharyngitis |
-
2012
- 2012-11-14 CN CN 201210455194 patent/CN102949516A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103285230A (en) * | 2013-06-13 | 2013-09-11 | 西安新通药物研究有限公司 | Pharmaceutical composition for treating pharyngitis and preparation method thereof |
| CN106389445A (en) * | 2016-11-17 | 2017-02-15 | 郑州郑先医药科技有限公司 | Western medicine compound preparation for treating chronic pharyngitis |
| CN106421137A (en) * | 2016-11-17 | 2017-02-22 | 郑州郑先医药科技有限公司 | Compound preparation for treating chronic pharyngitis |
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Application publication date: 20130306 |