CN100418567C - Medicine for treating cold and cough and its prepn process - Google Patents
Medicine for treating cold and cough and its prepn process Download PDFInfo
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- CN100418567C CN100418567C CNB2006100124531A CN200610012453A CN100418567C CN 100418567 C CN100418567 C CN 100418567C CN B2006100124531 A CNB2006100124531 A CN B2006100124531A CN 200610012453 A CN200610012453 A CN 200610012453A CN 100418567 C CN100418567 C CN 100418567C
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Abstract
The present invention relates to medicine for treating child's cold and cough and a preparing process thereof. The present invention is a medicament prepared from the raw material of the following weight compounding ratio: 30 to 33 portions of gypsum, 20 to 22 portions of mulberry bark, 20 to 22 portions of snakegourd fruit, 10 to 11 portions of peppery weed seed, 20 to 22 portions of ephedra, 20 to 22 portions of liquoric root, 30 to 33 portions of Radix Peucedani, 30 to 33 portions of aster, 20 to 22 portions of common coltsfoot flower, 20 to 22 portions of unibract fritillary bulb, 30 to 33 portions of bitter apricot seed, 0.09 to 0.1056 portion of perilla oil and 0.09 to 0.11 portion of menthol. Xiebai syrup prepared by the process of the present invention has the pharmacological actions of ventilating the lung, eliminating heat, eliminating phlegm and stopping cough and has the obvious therapeutic effects on fever, cough, phlegm generation, thirst, the dry tongue and the block nose caused by child's wind heat and internal stasis. The medicine has the advantages of single dose package, good mouth feeling and convenient use, is suitable for oral taking by children and can be easily accepted.
Description
Technical field
The present invention relates to a kind of medicine and preparation technology thereof who treats infantile cough due to common cold.
Technical background
The traditional Chinese medical science is thought: the cough with copious phlegm due to the children's wind-heat invading lung stagnation of fire in the interior, and thirsty dry tongue, it is obstructed to have a stuffy nose, and is common disease in children's's period, belongs to the category of modern medicine upper respiratory tract infection.
The present oral wonderful clever ball of children's, XIAOER ZHIKE TANGJIANG, Syrupus Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae, wean quick acting cold granules or cough-relieving syrup etc. can obtain medical treatment but therapeutic effect is not very satisfied, and take also not very convenient.
Summary of the invention
Technical problem to be solved by this invention provides a kind of infantile cough due to common cold that is used for the treatment of, abundant expectoration fullness in the chest, thirsty dry tongue, the Chinese medicine preparation obstructed and that therapeutic effect is good of having a stuffy nose.
Another object of the present invention just provides the preparation technology of the above-mentioned Chinese medicine preparation of preparation.
The present invention adopts following technical scheme:
The medicament that the present invention is made by the following weight proportion raw material
Gypsum Fibrosum 30-33 Cortex Mori 20-22 Semen Trichosanthis 20-22
Semen Lepidii (Semen Descurainiae) 10-11 Herba Ephedrae 20-22 Radix Glycyrrhizae 20-22
Radix Peucedani 30-33 Radix Asteris 30-33 Flos Farfarae 20-22
Bulbus Fritillariae Cirrhosae 20-22 Semen Armeniacae Amarum 30-33 Folium perillae acutae oil 0.09-0.1056
Mentholum 0.09-0.11
The preparation technology of the medicine of the treatment cough due to common cold of the present invention:
(1) extract aqua armeniacae: with the water of 5 times of weight of Semen Armeniacae Amarum adding, reflux, extract, distillation aqua armeniacae gets aqua armeniacae 90-100 weight portion, and is standby;
(2) with Gypsum Fibrosum, Radix Peucedani, Radix Asteris, Flos Farfarae, Cortex Mori, Semen Trichosanthis, Semen Lepidii (Semen Descurainiae), Herba Ephedrae, Radix Glycyrrhizae, Bulbus Fritillariae Cirrhosae add pure water and decoct twice, add the pure water of 7 times of weight for the first time, reflux, extract, 2 hours, it is standby to collect distillate 100-120 weight portion simultaneously; The leaching medicinal liquid; Add for the second time the pure water of 6 times of weight, decocted the leaching medicinal liquid 1 hour; Merge filtrate twice, under 0.06-0.09Mpa, 50--60 ℃ condition, be evaporated to the proportion that under 40-50 ℃ of temperature, records and be the concentrated medicament 180-200 weight portion of 1.05-1.1, standby;
(3) above-mentioned concentrated medicament is put to room temperature, added its weight 1-2 95% ethanol doubly, mixing leaves standstill and got supernatant in 24-48 hour, reclaims ethanol and gets extractum, and is standby;
(5) above-mentioned distillate, extractum are merged, mixing leaves standstill, and the leaching medicinal liquid is standby;
(5) Mentholum and Folium perillae acutae oil are put into to its weight 8-16 95% alcoholic solution doubly dissolves, standby;
(6) be that 85% the simple syrup 1600-1700 weight portion and the aqua armeniacae of 90-100 weight portion join in the medicinal liquid of leaching in above-mentioned the 4th step with above-mentioned Mentholum Folium perillae acutae oil ethanol liquid, concentration, mixing, be adjusted into the 2530-2640 weight portion with pure water, measuring relative density under 25 ℃ of temperature is 1.15-1.20, fill.
Good effect of the present invention is as follows:
In medicine of the present invention:
1, Gypsum Fibrosum: sweet, hot, Great Cold.Attach to the lung and stomach meridians.
Function with cure mainly: clearing away heat-fire, relieving restlessness is quenched the thirst.Be used for fever caused by exogenous pathogenic factors.The hyperpyrexia excessive thirst, cough due to lung-heat, the high Sheng of stomach-fire, headache, toothache.
Pharmacology: the artificial fever rabbit is had tangible antipyretic effect.The amount of drinking water that can suppress experimental thirsty rat.The mice voided volume is increased.The bile of rat and cat is discharged to be increased.The phagocytic function of rabbit pulmonary alveolar macrophage can be obviously strengthened, and cytophagous maturation can be promoted white grapes ball and gold colloidal.Suppress neural stress ability, reduce the irritability of skeletal muscle, relieve muscle spasms.
2, Cortex Mori: sweet, cold.Return lung meridian.
Function with cure mainly: eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.Be used for dyspnea and cough due to lung-heat, edema distension oliguria, appearance skin edema.
Pharmacology: decocting liquid is antitussive slightly, and the rat paw edema that on Carrageenan and Fructus Vitis viniferae cause has inhibitory action.To staphylococcus aureus, shigella flexneri etc. have inhibitory action.The decoct mouse stomach has diuresis and catharsis effect.
3, Semen Fructus Trichosanthis: sweet, cold.Return lung, the stomach large intestine channel.
Function with cure mainly: moistening the lung and resolving phlegm, laxation relieving constipation.It is glutinous to be used for cough caused by dryness expectorant, the dryness of the intestine constipation.
Pharmacology: decoct mouse stomach, visible discharge function.To rats gavaged the sputum of promotion secretory action is arranged, to escherichia coli, the Song Shi dysentery bacterium, Bacillus typhi etc. have certain inhibitory action.
4, Semen Lepidii (Semen Descurainiae): suffering, hardship, Great Cold.Return lung, urinary bladder channel.
Function with cure mainly: eliminating pathogen from the lung for relieving asthma, line water detumescence is used for dyspnea and cough with excessive sputum, fullness and distention in the chest and hypochondrium must not be put down for sleeping inly, ascites pleural fluid is swollen, dysuria, pulmonary heart disease edema.
Pharmacology: contain cardiac glycoside spiritual beings matter, rabbit, proof has the effect that increases the heartbeat output on the cat heart failure model.To multiple funguses such as various bacteria and yeast, tens of kinds of other bacterial strains all have antibacterial action.Eliminate the phlegm diuresis.
5, Herba Ephedrae: hot, little hardship, temperature.Return lung, urinary bladder channel.
Function with cure mainly: diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.Be used for anemofrigid cold, uncomfortable in chest breathing with cough, edema due to wind pathogen edema, bronchial asthma.
Pharmacology: decoct and volatile oil gavage peptone heating Mus and milk heating rabbit all refrigeration function, and Herba Ephedrae water extract and ephedrine are given rats gavaged, make the diaphoresis of rat vola portion.The people at high temperature gives ephedrine visible amount of sweat increase.The antitussive of relievining asthma, Herba Ephedrae water extract 12 fat enteral administrations, Mus amine asthma or the contraction of anesthetized dog histamine trachea all there is antagonism, the total alkali of water extract and ephedrine also have same bronchiectasis and the effect of antihistamine asthma, ephedrine also has the central antitussive effect, the vinegar mouse peritoneal is closed disease, and the rat dextran has remarkable inhibitory action.Remarkable diuresis is arranged.
6, Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.
Function with cure mainly: sharp spleen QI invigorating, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the abdomen that expands, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Pharmacology: Radix Glycyrrhizae soap tongue is to CCl
4The hepatotoxicity that causes has protective effect; glycyrrhizin can reverse hepatic fibrosis and early stage liver cirrhosis; the glycyrrhizin oleanolic acid is to the pathomorphism damage effect of having clear improvement of the inferior chronic cadium poisoning gastric injury of rat, and Radix Glycyrrhizae is by regulating intestinal epithelial cell propagation performance mucous membrane protection and repair.
7, Radix Peucedani: bitter, hot, be slightly cold.Return lung meridian.
Function with cure mainly: the wind heat clearing away of loosing, lowering the adverse-rising QI to resolve phlegm.Be used for cough due to pathogenic wind-heat's abundant expectoration, the expectorant dyspnea of heat type is full, the yellow silk fabric of coughing up phlegm.
Pharmacology: can significantly increase the mucus secretion of animal breath road, and the persistent period is longer, has antibiotic and antifungic action, suppresses smooth muscle contraction, anti-allergic effects.
8, Radix Asteris: hot, bitter, warm.Return lung meridian.
Function with cure mainly: nourishing the lung to keep the adverse QI downward, stopping coughing and removing phlegm.Be used for abundant expectoration and breath with cough, the chronic cough hemoptysis.
Pharmacology: the decoct mouse stomach has remarkable phlegm-dispelling functions.The purple first of composition have antitussive action.To escherichia coli, dysentery bacterium, Bacillus proteus, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus and cholera bacteria have certain inhibitory action, and influenza virus is also had effect.
9, Flos Farfarae: hot, little hardship, temperature.Return lung meridian.
Function with cure mainly: nourishing the lung to keep the adverse QI downward, relieving cough and resolving phlegm.Be used for dyspnea and cough with excessive sputum, the chronic cough hemoptysis.
Pharmacology: significant antitussive effect is arranged, phlegm-dispelling functions is also arranged.
10, Bulbus Fritillariae Cirrhosae: bitter, sweet, be slightly cold.Return lung, heart channel.
Function with cure mainly: clearing heat and moistening lung, preventing phlegm from forming and stopping coughing.Make an uproar with lung-heat and to cough, the few expectorant of dry cough, deficiency of YIN chronic cough, cough with blood-flecked phlegm.
Pharmacology:, the antitussive effect of highly significant is arranged to the cough that the electricity irritation superior laryngeal nerve causes.Fritimine, Bulbus Fritillariae Cirrhosae saponin all make the phenol red excretion method of mice be the phlegm-dispelling functions of the different increase of degree.Can loose tracheal smooth muscle.The inhibition nocadia is arranged, staphylococcus aureus and escherichia coli effect.
11, Semen Armeniacae Amarum: hardship, tepor, slightly poisonous.Return lung, large intestine channel.
Function with cure mainly: sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation.Be used for cough and asthma, the fullness in the chest abundant expectoration, blood deficiency Tianjin is withered, the dryness of the intestine constipation.
Pharmacology: resolve into hydrocyanic acid in the amygdaloside body, can suppress respiratory center, reach the antitussive and antiasthmatic effect, can also promote the synthetic of pulmonary surfactant, help respiratory function.
12, Folium perillae acutae oil: hot, warm.Return lung, spleen channel.
Function with cure mainly: the cold expelling that induces sweat, relieving QI stagnancy in the stomach.Be used for anemofrigid cold, the cough vomiting and nausea, vomiting during pregnancy, the fish Eriocheir sinensis poisons.
13, Mentholum: aromatic drug, remedium corrigens and carminative.Can be used for skin or mucosa and produce refrigerant sense to alleviate discomfort and pain.
Pharmacology: to pathogen, various bacteria and virus have inhibitory action, and the promotion telangiectasis is arranged, and promote sweat gland secretion, accelerate heat radiation, and the sweating and heat resolving effect is arranged, and the antiinflammatory phlegm-dispelling functions is arranged.
Medicine purging pathogenic fire of the lung syrup treatment infantile cough due to common cold (upper respiratory tract infection) clinical research scheme of the present invention:
One, case choice criteria
(1) diagnostic criteria
1, tcm diagnosis standard
(1) heating, aversion to cold, nasal obstruction, watery nasal discharge, sneeze.
All had in (2) four o'clock, and be more common in the Winter-Spring, often fall ill because of the weather cataclysm.
(3) have cough concurrently more.
2, Chinese medical discrimination
Wind-heat syndrome
Heating is heavy, and aversion to cold is light, and antiperspirant is arranged, headache, and nasal obstruction, rhinorrhea, sneeze, cough, it is yellow thick to spit, red swelling of the pharynx pain, xerostomia is and thirsty, and red tongue white and thin fur or BOHUANG, floating and rapid pulse floating superficial venule of the index finger are revealed, and color is redder red.
Accompanied symptoms
Hold expectorant under the arm: cough is acute, heavy cough, gurgling with sputum, greasy, the floating-rolling pulse number of thick fur.
3, Western medicine diagnose standard and typing
Primary disease is according to heating, the nasal obstruction watery nasal discharge, and primary symptoms such as sneeze are made diagnosis easily, are divided into 3 types by its state of an illness weight:
Light-duty: generate heat 37 ℃～38 ℃, the wake tears, sneeze, headache can have slight cough, hoarseness pharyngalgia, pharyngeal hyperemia, tonsil silght enlargement, hyperemia.
Medium-sized: generate heat 38 ℃～39 ℃, the wake tears, sneeze, the nasal obstruction headache can have the moderate cough, hoarseness, pharyngeal hyperemia, antiadoncus, retropharyneal folliculosis, general malaise, loss of appetite.
Heavy: heating is accompanied general malaise more than 39 ℃, and spirit is poor, inappetence, fear of cold, headache, cough and sniffle are heavier, hoarseness can be arranged, pharyngalgia, pharyngeal hyperemia is obvious, and antiadoncus can have stigma shape exudate on isthmus faucium portion or the tonsil, pharyngeal cavity, visible canescence bubble rash ulcer on the staphyleus mucosa of soft palate, visible conjunctival congestion, edema or folliculus etc.
(2) test case standard
1, includes the case standard in
Meet primary disease diagnosis and differential diagnosis in tcm standard, the course of disease is no more than 3 days persons, can include the test case in.
2, get rid of case standard (comprising inadaptation or rejecting standard)
(1) severe malnutrition or with other cardiovascular, liver, kidney and hemopoietic system and serious systemic disease person, the psychotic is to this medicine allergy sufferers.
(2) suppurative tonsillitis, patients such as bronchitis, bronchiolitis, pneumonia.
(3) do not meet the standard of including in, do not adhere to taking medicine, change dressings or dosing midway, can't judge that curative effect or data are not congruent to affect the treatment or safety judgement person.
Two, observation index
1, safety observation
(1) general health check-up project
(2) blood, urine, just routine test
(3) heart, liver, kidney function test
2, health giving quality observation
(1) symptom: heating, aversion to cold, sniffle, cough, pharyngeal symptom, whole body situation.
(2) sign: body temperature, pharynx, tonsil inspection, picture of the tongue, pulse condition, fingerprint etc.
(3) laboratory routine examination: total white blood cells and differential counting, routine urinalysis, stool routine examination.
(4) respiratory secretions or Nasopharyngeal swabs are sent antibacterial culturing.
Three, curative effect determinate standard
1, recovery from illness: took medicine 24-48 hour in, temperature recovery is normal, and the card marquis disappears, and unusual physical and chemical index recovers normal.
2, produce effects: took medicine 24-48 hour in, temperature recovery is normal, mainly demonstrate,proves the most of disappearance of marquis, and unusual physical and chemical index is near normal.
3, effective: took medicine 48-72 hour in, temperature recovery is normal, mainly demonstrate,proves the marquis and partly disappears, and unusual physical and chemical index makes moderate progress.
4, invalid: as not meet above standard person.
Four, clinical trial medicine: medicine purging pathogenic fire of the lung syrup of the present invention, composition: the syrup that Gypsum Fibrosum, Cortex Mori, Semen Trichosanthis, Herba Ephedrae, Radix Glycyrrhizae, Radix Peucedani, Radix Asteris, Flos Farfarae, Bulbus Fritillariae Cirrhosae, Semen Armeniacae Amarum, Folium perillae acutae oil, Mentholum, sucrose are made, every 10ml.Function cures mainly: lung qi dispersing is analgesic, preventing phlegm from forming and stopping coughing.Be used for the cough due to common cold, the many fullness in the chest of disease, thirsty dry tongue, nasal obstruction is uncomfortable.Usage and consumption: oral, above each 10ml of one full year of life, following each 5ml of one full year of life, 2 times on the one.
Five, observe step: all are included case in and all fill in unified case history and observe registration form, obey trial drug purging pathogenic fire of the lung syrup every day.Above each 10ml of one full year of life, following each 5ml of one full year of life, 2 times on the one, 3 days is a course of treatment.Period in a medicine is withdrawn other cough suppressing medicine, and matched group is taken Syrupus Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae, and finish the course of treatment, does every inspection again, carries out statistical analysis respectively, writes out final report.
Medicine purging pathogenic fire of the lung syrup treatment infantile cough due to common cold (upper respiratory tract infection) of the present invention
235 routine clinical observations
In January, 2004 to 2005, year JIUYUE adopted oral medicine purging pathogenic fire of the lung syrup of the present invention to treat to the infant of the 235 routine cough due to common colds (upper respiratory tract infection), had obtained satisfied effect, now was summarized as follows:
1, physical data: infantile cough due to common cold (upper respiratory tract infection) and diagnostic criteria, select case according to " the purging pathogenic fire of the lung syrup is treated children's exogenous clinical research scheme " diagnostic criteria that the children's exogenous treatment clinical guidance of Ministry of Public Health principle is drafted.
This group is totally 235 examples, 1-2 year 85 examples, 3-6 year 150 examples, male 121 examples, women 114 examples.Other establishes 126 routine matched groups, and at the age, sex and treatment group are basic identical, between 37 ℃～39 ℃ of two groups of body temperature, go to a doctor in 2 days in heating, cough is in various degree all arranged, watery nasal discharge, pharyngalgia, headache is checked and is removed pharyngeal congestion, outside tonsil increase and the respiratory harshness, do not have other positive sign, and lower respiratory infection etc. is got rid of in Chest X-rays.
2, Therapeutic Method:
Treatment group medicine purging pathogenic fire of the lung of the present invention syrup contains composition: Gypsum Fibrosum, Cortex Mori, Semen Trichosanthis, Semen Lepidii (Semen Descurainiae), Herba Ephedrae, Radix Glycyrrhizae, Radix Peucedani, Radix Asteris, Flos Farfarae, Bulbus Fritillariae Cirrhosae, Semen Armeniacae Amarum, Folium perillae acutae oil, Mentholum.Oral: above each 10ml of one full year of life, following each 5ml of one full year of life, 2 times on the one, the oral Syrupus Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae of matched group, 3 days courses of treatment.
Criterion of therapeutical effect: (1) recovery from illness: took medicine 24-48 hour in, temperature recovery is normal, and the card marquis disappears, and unusual physical and chemical index recovers normal.(2) produce effects: took medicine 24-48 hour in, temperature recovery is normal, mainly demonstrate,proves the most of disappearance of marquis, and unusual physical and chemical index is near normal.(3) effective: took medicine 48-72 hour in, temperature recovery is normal, mainly demonstrate,proves the marquis and partly disappears, and unusual physical and chemical index has clear improvement.(4) invalid: as not meet above standard person.
3, result: the treatment group is cured 164 examples, produce effects 52 examples, effective 18 examples, invalid 1 example, total effective rate 99.6%; Matched group is cured 38 examples, produce effects 35 examples, and effective 18 examples, invalid 35 examples, total effective rate compares for 72.2%, two group, and difference has significance meaning (p＜0.01).
The results are shown in Table:
P＜0.01
4, discuss: infantile fever caused by exogenous pathogens, cough, nasal obstruction, watery nasal discharge belong to the category of modern medicine respiratory tract infection, it is modal disease in children's's period, morbidity accounts for the first place of Pediatrics Department disease, and medicine purging pathogenic fire of the lung syrup of the present invention has the pharmacological action of the analgesic preventing phlegm from forming and stopping coughing of lung qi dispersing.To children's wind-heat invading lung, the fever and cough due to the stagnation of fire in the interior, abundant expectoration, thirsty dry tongue, nasal obstruction is not connected with notable therapeutic effect, unit dose package, mouthfeel is good, and taking convenience is applicable to that children's is oral, and is willing to accept.
The specific embodiment
Embodiment 1
The medicament that a kind of medicine for the treatment of the cough due to common cold is made by the raw material of following weight
Gypsum Fibrosum 30-33g Cortex Mori 20-22g Semen Trichosanthis 20-22g
Semen Lepidii (Semen Descurainiae) 10-11g Herba Ephedrae 20-22g Radix Glycyrrhizae 20-22g
Radix Peucedani 30-33g Radix Asteris 3033g Flos Farfarae 20-22g
Bulbus Fritillariae Cirrhosae 20-22g Semen Armeniacae Amarum 30-33g Folium perillae acutae oil 0.09-0.1056g
Mentholum 0.09-0.11g
The preparation method of the medicine of the above-mentioned treatment cough due to common cold:
(1) extract aqua armeniacae, Semen Armeniacae Amarum is added water 5 amounts, reflux, extract, distillation aqua armeniacae 100ml, standby.
(2) with Gypsum Fibrosum, Radix Peucedani, Radix Asteris, Flos Farfarae, Cortex Mori, Semen Trichosanthis, Semen Lepidii (Semen Descurainiae), Herba Ephedrae, Radix Glycyrrhizae, Bulbus Fritillariae Cirrhosae add pure water and decoct secondary, add the pure water of 7 times of weight for the first time, reflux, extract, 2 hours, and it is standby to collect distillate 120ml simultaneously, the leaching medicinal liquid.For the second time add 6 times of weight pure water, decocted 1 hour, the leaching medicinal liquid merges above-mentioned twice filtrate, under 0.06-0.09Mpa 50-60 ℃ condition, is evaporated to the proportion that records and is 1.05-1.1 concentrated medicament 200ml under 40-50 ℃ of temperature, and is standby;
(3) above-mentioned concentrated medicament is put to room temperature, added 95% ethanol 200ml, mixing left standstill 24 hours, got supernatant, reclaimed ethanol, and it is standby to get extractum;
(4) with distillate 120ml, extractum merges, and mixing leaves standstill, and the leaching medicinal liquid is standby;
(5) with Mentholum, Folium perillae acutae oil is with 2ml 95% dissolve with ethanol, and is standby.
(6) above-mentioned Mentholum Folium perillae acutae oil ethanol liquid, aqua armeniacae and 85% simple syrup 1300ml are added in the medicinal liquid of leaching in above-mentioned the 4th step, mixing is 2200ml with pure water adjustment capacity, measures relative density 1.15-1.20 (25 ℃), fill, every bottle of 10ml promptly.
Embodiment 2
The medicament that a kind of medicine following weight proportion raw material for the treatment of the cough due to common cold is made
Gypsum Fibrosum 30 Cortex Mori 20 Semen Trichosanthis 21
Semen Lepidii (Semen Descurainiae) 10 Herba Ephedraes 20 Radix Glycyrrhizaes 20 Radix Peucedanis 30 Radix Asteriss 30 Flos Farfaraees 20
Bulbus Fritillariae Cirrhosae 20 Semen Armeniacae Amarums 30 Folium perillae acutae oils 0.1
Mentholum 0.09
The preparation method of the medicine of the above-mentioned treatment cough due to common cold:
(1) extract aqua armeniacae: with the water of 5 times of weight of Semen Armeniacae Amarum adding, reflux, extract, distillation aqua armeniacae gets aqua armeniacae 95 weight portions, and is standby;
(2) with Gypsum Fibrosum, Radix Peucedani, Radix Asteris, Flos Farfarae, Cortex Mori, Semen Trichosanthis, Semen Lepidii (Semen Descurainiae), Herba Ephedrae, Radix Glycyrrhizae, Bulbus Fritillariae Cirrhosae add pure water and decoct twice, add the pure water of 7 times of weight for the first time, reflux, extract, 2 hours, it is standby to collect distillate 110 weight portions simultaneously; The leaching medicinal liquid; Add for the second time the pure water of 6 times of weight, decocted the leaching medicinal liquid 1 hour; Merge filtrate twice, under 0.061Mpa, 55 ℃ of conditions, be evaporated to the proportion that under 40 ℃ of temperature, records and be 1.05 concentrated medicament 180 weight portions, standby;
(3) above-mentioned concentrated medicament is put to room temperature, added 95% ethanol of 1 times of its weight, mixing leaves standstill and got supernatant in 24 hours, reclaims ethanol and gets extractum, and is standby;
(4) above-mentioned distillate, extractum are merged, mixing leaves standstill, and the leaching medicinal liquid is standby;
(5) Mentholum and Folium perillae acutae oil are incorporated as in 95% alcoholic solution of 8 times of its weight and dissolve, standby;
(6) be that 85% simple syrup 1600 weight portions and the aqua armeniacae of 90 weight portions join in the medicinal liquid of leaching in above-mentioned the 4th step with above-mentioned Mentholum Folium perillae acutae oil ethanol liquid, concentration, mixing, be adjusted into 2530 weight portions with pure water, measuring relative density under 25 ℃ of temperature is 1.15, fill.
Embodiment 3
The medicament that a kind of medicine following weight proportion raw material for the treatment of the cough due to common cold is made
Gypsum Fibrosum 33 Cortex Mori 21 Semen Trichosanthis 20
Semen Lepidii (Semen Descurainiae) 11 Herba Ephedraes 22 Radix Glycyrrhizaes 21
Radix Peucedani 31 Radix Asteriss 33 Flos Farfaraees 21
Bulbus Fritillariae Cirrhosae 22 Semen Armeniacae Amarums 33 Folium perillae acutae oils 0.09 Mentholum 0.11
The preparation method of the medicine of the above-mentioned treatment cough due to common cold:
(1) extract aqua armeniacae: with the water of 5 times of weight of Semen Armeniacae Amarum adding, reflux, extract, distillation aqua armeniacae gets aqua armeniacae 90 weight portions, and is standby;
(2) with Gypsum Fibrosum, Radix Peucedani, Radix Asteris, Flos Farfarae, Cortex Mori, Semen Trichosanthis, Semen Lepidii (Semen Descurainiae), Herba Ephedrae, Radix Glycyrrhizae, Bulbus Fritillariae Cirrhosae add pure water and decoct twice, add the pure water of 7 times of weight for the first time, reflux, extract, 2 hours, it is standby to collect distillate 100 weight portions simultaneously; The leaching medicinal liquid; Add for the second time the pure water of 6 times of weight, decocted the leaching medicinal liquid 1 hour; Merge filtrate twice, under 0.07Mpa, 50 ℃ of conditions, be evaporated to the proportion that under 50 ℃ of temperature, records and be 1.0 concentrated medicament 200 weight portions, standby;
(3) above-mentioned concentrated medicament is put to room temperature, added 95% ethanol of 2 times of its weight, mixing leaves standstill and got supernatant in 36 hours, reclaims ethanol and gets extractum, and is standby;
(4) above-mentioned distillate, extractum are merged, mixing leaves standstill, and the leaching medicinal liquid is standby;
(5) Mentholum and Folium perillae acutae oil are incorporated as in 95% alcoholic solution of 12 times of its weight and dissolve, standby;
(6) be that 85% simple syrup 1650 weight portions and the aqua armeniacae of 95 weight portions join in the medicinal liquid of leaching in above-mentioned the 4th step with above-mentioned Mentholum Folium perillae acutae oil ethanol liquid, concentration, mixing, be adjusted into 2640 weight portions with pure water, measuring relative density under 25 ℃ of temperature is 1.17, fill.
Embodiment 4
The medicament that a kind of medicine following weight proportion raw material for the treatment of the cough due to common cold is made
Gypsum Fibrosum 31 Cortex Mori 22 Semen Trichosanthis 22
Semen Lepidii (Semen Descurainiae) 10.5 Herba Ephedraes 21 Radix Glycyrrhizaes 22
Radix Peucedani 33 Radix Asteriss 31 Flos Farfaraees 22
Bulbus Fritillariae Cirrhosae 21 Semen Armeniacae Amarums 31 Folium perillae acutae oils 0.1056
Mentholum 0.1
The preparation method of the medicine of the above-mentioned treatment cough due to common cold:
(1) extract aqua armeniacae: with the water of 5 times of weight of Semen Armeniacae Amarum adding, reflux, extract, distillation aqua armeniacae gets aqua armeniacae 100 weight portions, and is standby;
(2) with Gypsum Fibrosum, Radix Peucedani, Radix Asteris, Flos Farfarae, Cortex Mori, Semen Trichosanthis, Semen Lepidii (Semen Descurainiae), Herba Ephedrae, Radix Glycyrrhizae, Bulbus Fritillariae Cirrhosae add pure water and decoct twice, add the pure water of 7 times of weight for the first time, reflux, extract, 2 hours, it is standby to collect distillate 120 weight portions simultaneously; The leaching medicinal liquid; Add for the second time the pure water of 6 times of weight, decocted the leaching medicinal liquid 1 hour; Merge secondary filtrate, under 0.09Mpa, 60 ℃ of conditions, be evaporated to the proportion that under 45 ℃ of temperature, records and be 1.1 concentrated medicament 190 weight portions, standby;
(3) concentrated medicament is put to room temperature, added 95% ethanol of 1.5 times of its weight, mixing leaves standstill and got supernatant in 48 hours, reclaims ethanol and gets extractum, and is standby;
(4) above-mentioned distillate, extractum are merged, mixing leaves standstill, and the leaching medicinal liquid is standby;
(5) Mentholum and Folium perillae acutae oil are incorporated as in 95% alcoholic solution of 16 times of its weight and dissolve, standby;
(6) be that 85% simple syrup 1700 weight portions and the aqua armeniacae of 100 weight portions join in the medicinal liquid of leaching in above-mentioned the 4th step with above-mentioned Mentholum Folium perillae acutae oil ethanol liquid, concentration, mixing, be adjusted into 2600 weight portions with pure water, measuring relative density under 25 ℃ of temperature is 1.20, fill.
Claims (2)
1. medicine for the treatment of the cough due to common cold is characterized in that it is the medicament of being made by following raw materials by weight proportions:
Gypsum Fibrosum 30-33, Cortex Mori 20-22, Semen Trichosanthis 20-22,
Semen Lepidii (Semen Descurainiae) 10-11, Herba Ephedrae 20-22, Radix Glycyrrhizae 20-22,
Radix Peucedani 30-33, Radix Asteris 30-33, Flos Farfarae 20-22,
Bulbus Fritillariae Cirrhosae 20-22, Semen Armeniacae Amarum 30-33, Folium perillae acutae oil 0.09-0.1056,
Mentholum 0.09-0.11.
2. the preparation technology of the medicine of a treatment cough due to common cold according to claim 1:
(1) extract aqua armeniacae: with the water of 5 times of weight of Semen Armeniacae Amarum adding, reflux, extract, distillation aqua armeniacae gets aqua armeniacae 90-100 weight portion, and is standby;
(2) with Gypsum Fibrosum, Radix Peucedani, Radix Asteris, Flos Farfarae, Cortex Mori, Semen Trichosanthis, Semen Lepidii (Semen Descurainiae), Herba Ephedrae, Radix Glycyrrhizae, Bulbus Fritillariae Cirrhosae add pure water and decoct twice, add the pure water of 7 times of weight for the first time, reflux, extract, 2 hours, it is standby to collect distillate 100-120 weight portion simultaneously; The leaching medicinal liquid; Add for the second time the pure water of 6 times of weight, decocted the leaching medicinal liquid 1 hour; Merge filtrate twice, under 0.06-0.09Mpa, 50--60 ℃ condition, be evaporated to the proportion that under 40-50 ℃ of temperature, records and be the concentrated medicament 180-200 weight portion of 1.05-1.1, standby;
(3) above-mentioned concentrated medicament is put to room temperature, added its weight 1-2 95% ethanol doubly, mixing leaves standstill and got supernatant in 24-48 hour, reclaims ethanol and gets extractum, and is standby;
(4) above-mentioned distillate, extractum are merged, mixing leaves standstill, and the leaching medicinal liquid is standby;
(5) Mentholum and Folium perillae acutae oil are put into to its weight 8-16 95% alcoholic solution doubly dissolves, standby;
(6) be that 85% the simple syrup 1600-1700 weight portion and the aqua armeniacae of 90-100 weight portion join in the medicinal liquid of leaching in above-mentioned the 4th step with above-mentioned Mentholum Folium perillae acutae oil ethanol liquid, concentration, mixing, be adjusted into the 2530-2640 weight portion with pure water, measuring relative density under 25 ℃ of temperature is 1.15-1.20, fill.
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| CN101229319B (en) * | 2008-01-16 | 2010-09-01 | 严浩成 | Cold cough oral liquid |
| CN102526152A (en) * | 2012-02-17 | 2012-07-04 | 张奎昌 | Preparation method for tussilago farfara extract |
| CN106266499A (en) * | 2015-06-10 | 2017-01-04 | 葛以东 | A kind of formula controlling cough out of breath |
| CN115089670B (en) * | 2022-07-14 | 2023-10-24 | 保定中药制药股份有限公司 | Medicine for treating cold cough and preparation process thereof |
| CN115919992A (en) * | 2023-01-04 | 2023-04-07 | 张景祖 | Traditional Chinese medicine composition for treating chronic obstructive pulmonary disease and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1136885C (en) * | 2001-02-23 | 2004-02-04 | 邓万发 | Chinese medicine for treating dyspneic cough effectively |
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| CN1136885C (en) * | 2001-02-23 | 2004-02-04 | 邓万发 | Chinese medicine for treating dyspneic cough effectively |
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| 小儿肺炎的中药治疗概况. 刘淑霞等.陕西中医学院学报，第20卷第4期. 1997 |
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