CN105168638A - Traditional Chinese medicinal liquid band aid for preventing and treating bedsore complicated with bacterial infection - Google Patents
Traditional Chinese medicinal liquid band aid for preventing and treating bedsore complicated with bacterial infection Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicinal liquid band aid for preventing and treating bedsore complicated with bacterial infection. The band aid is prepared from climbing groundsel herb, green holly, calamine, radix paeoniae rubra, cocklebur fruit, vitischungii metcalf, emilia sonchifolia, scutellaria indica and angled bittersweet root which serve as active ingredients according to certain parts by weight, as well as polyvinyl acetal, dibutyl phthalate, methyl cellulose, glycerol, laurocapram, ethanol and ethyl acetate. The band aid has functions of clearing away heat and toxic materials, diminishing inflammation and relieving swelling, promoting blood circulation and removing stasis, removing necrotic tissues and promoting generation of new tissues; the band aid is capable of effectively controlling growth and propagation of infectious pathogenic bacteria, and is simultaneously capable of improving microcirculation around a wound surface, enhancing local blood flow, promoting growth of granulation tissue and accelerating healing. The band aid is convenient to use and is not limited by the shape, size and location of wound; and meanwhile, the band aid is good in water-proofing and air-permeable properties, non-sticky to clothes, and free from allergy and drug tolerance.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to the Chinese medicinal liquor bandage of a kind of prevention, treatment decubital ulcer merging bacteriological infection.
Background technology
Pressure ulcer is because body part organizes long-term pressurized, disturbance of blood circulation, histotrophic nutrition to lack, and causes skin to lose normal function and the tissue damage caused and necrosis.Pressure ulcer itself is not primary disease, is the skin injury because other primary diseases cause without nursing very well mostly.Cause the most basic, the most important factor of pressure ulcer be cause due to compressing local organization ischemia, anoxia and necrosis.
The sickness rate of decubital ulcer is in the trend risen in recent years, and decubital ulcer also exists certain difficulty in treatment.Occur decubital ulcer patient in, be mostly senile disease as cerebrovascular, senile dementia etc., especially handicapped long-term bed, have bad physiques, limbs sensation laggards in the majority.Once generation decubital ulcer, not only bring misery to patient, increase the weight of the state of an illness, delay the time of rehabilitation, time serious, also can cause septicemia and crisis life because of secondary infection.
Decubitus ulcer place is just as an open wound, and its exposes in atmosphere, and wound surface has more the mixed infection of aerobe, anaerobe and facultative anaerobe, great majority are staphylococcus aureuses, micrococcus scarlatinae.Adopt routine disinfection at present more, single antibiotic or the coating of other antibacterial, because these medicines have stronger stimulation to wound surface, be unfavorable for growth and the wound healing of granulation tissue, the course of disease is longer, and due to its irregular use, the drug resistance that current microorganism occurs, have also appeared superbacteria even now.When using these medicines simultaneously, do not cover gauze and then easily cause skin and bed etc. to form scratch, cover gauze and easily cause again dressing and wound surface adhesion, more easily cause mechanical damage when changing dressings, increase patient pain's sense, even can expand wound surface.Address these problems and the infection of prevention and corntrol decubital ulcer is seemed particularly outstanding.
Summary of the invention
In order to timely and effective control decubital ulcer can infect, alleviate patient suffering, while the Growth and reproduction of effective infection control pathogen, promote granulation tissue growth, accelerate healing, inventor provide the Chinese medicinal liquor bandage of a kind of prevention, treatment decubital ulcer merging bacteriological infection, it is easy to use, not by the restriction at shape of wound, size, residing position, simultaneously water proof, good permeability, be not stained with clothing cotton-padded mattress, do not produce anaphylaxis and drug resistance.
In order to realize object of the present invention, the invention provides the Chinese medicinal liquor bandage of a kind of prevention, treatment decubital ulcer merging bacteriological infection, being made up of following Chinese crude drug and adjuvant,
Described Chinese crude drug is: Herba Senecionis Scandentis, Ilex viridis Champ., Calamina, Radix Paeoniae Rubra, Fructus Xanthii, Radix Vitis chungii, Herba Duchesneae Indicae, Herba Scutellariae indicae, Radix Celastri Angulati;
Described adjuvant is: Pioloform, polyvinyl acetal 30-40 part, dibutyl phthalate 6-9 part, methylcellulose 2-6 part, glycerol 7.5-18 part, laurocapram 10-15 part, ethanol 150-200 part, ethyl acetate 30-50 part.
Wherein, solid constituent with the corresponding relation of liquid components is: solid part unit is liquid part unit that g is corresponding is mL, or solid part unit be liquid part unit that Kg is corresponding is L.
Preferably, the weight of Chinese crude drug described above is: Herba Senecionis Scandentis 15-30 part, Ilex viridis Champ. 15-30 part, Calamina 3-6 part, Radix Paeoniae Rubra 9-15 part, Fructus Xanthii 5-15 part, Radix Vitis chungii 9-17 part, Herba Duchesneae Indicae 6-18 part, Herba Scutellariae indicae 10-20 part, Radix Celastri Angulati 5-15 part.
Further preferably, the weight of Chinese crude drug described above is: Herba Senecionis Scandentis 20-25 part, Ilex viridis Champ. 18-23 part, Calamina 3-6 part, Radix Paeoniae Rubra 9-12 part, Fructus Xanthii 5-8 part, Radix Vitis chungii 12-15 part, Herba Duchesneae Indicae 11-15 part, Herba Scutellariae indicae 13-18 part, Radix Celastri Angulati 8-13 part.
Further preferably, the weight of Chinese crude drug described above is: Herba Senecionis Scandentis 20 parts, Ilex viridis Champ. 18 parts, Calamina 3.5 parts, Radix Paeoniae Rubra 10 parts, Fructus Xanthii 6 parts, Radix Vitis chungii 13 parts, Herba Duchesneae Indicae 12 parts, Herba Scutellariae indicae 15 parts, Radix Celastri Angulati 9 parts;
Described adjuvant is: Pioloform, polyvinyl acetal 33 parts, dibutyl phthalate 7 parts, methylcellulose 4.5 parts, glycerol 12 parts, laurocapram 12 parts, ethanol 170 parts, ethyl acetate 45 parts.
Medicine liquid bandage of the present invention is made primarily of Chinese medicine Herba Senecionis Scandentis, Ilex viridis Champ., Calamina, Radix Paeoniae Rubra, Fructus Xanthii, Radix Vitis chungii, Herba Duchesneae Indicae, Herba Scutellariae indicae, the effective Chinese medicine of Radix Celastri Angulati 9 taste, effect heat-clearing and toxic substances removing, anti-inflammation detumescence, blood circulation promoting and blood stasis dispelling, putrefaction removing and tissue regeneration promoting.In prescription, Radix Vitis chungii detumescence and drawing out poison, Herba Senecionis Scandentis has heat-clearing and toxic substances removing, removing heat from blood to subside a swelling, antipruritic effect, two medicine 5 detumescences of drawing out pus by applying a plaster to the affected part, and makes the outer row of evil poison be monarch drug; Ilex viridis Champ. has the merit of removing pathogenic heat from blood and toxic substance from the body, putrefaction removing and tissue regeneration promoting; Radix Paeoniae Rubra can purify the blood a point pathogenic heat, and dissipating blood stasis blood is detained; Herba Duchesneae Indicae heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, three medicines 5 are with can heat-clearing and toxic substances removing, and removing pathogenic heat from blood and toxic substance from the body again, dissipating blood stasis for subsidence of swelling, strengthen the merit of monarch drug heat-clearing and toxic substances removing, reducing swelling and alleviating pain, and accelerating promoting tissue regeneration by removing blood stasis, is ministerial drug; Herba Scutellariae indicae energy heat-clearing and toxic substances removing, promoting blood circulation and stopping pain, hemostasia and detumescence, Radix Celastri Angulati expelling wind and removing dampness, promoting blood circulation to restore menstrual flow, the dehumidifying of Fructus Xanthii powder wind, understand things pain-stopping, three medicine compatibilities use, can heat-clearing and toxic substances removing, and promoting blood circulation to remove blood stasis pain relieving again, expel wind to dredge collateral toxin expelling are adjuvant drug; Calamina has the merit of the antipruritic sore of removing dampness, for making medicine.Medicine closes with card, can the Growth and reproduction of effective infection control pathogen, and improve microcirculation around wound surface simultaneously, increase regional flow, promote granulation tissue growth, quickening is healed.
In side, the pharmacological property of each medical material is as follows:
Herba Senecionis Scandentis: [nature and flavor] bitter in the mouth; Pungent; Cold in nature.[function cures mainly] heat-clearing and toxic substances removing; Improving acuity of vision and removing nebula; Killing parasites for relieving itching.
Main flow sense; Upper respiratory tract infection; Pneumonia; Acute tonsillitis; Rib adenitis; Acute enteritis; Bacillary dysentery; Icterohepatitis;
Gallbladder exudative dermatitis is scorching; Acute urinary tract infection; Conjunctival congestion and swelling pain cataracta; Carbuncle furuncle poison; Erysipelas; Eczema; Dry exudative dermatitis skin ulcer; Trichomonal vaginitis; Burn and scald.Modern study shows: Herba Senecionis Scandentis decoct, stronger antibacterial action is had to will Hayes dysentery bar mattress and staphylococcus aureus, to bacillus such as typhoid fever, paratyphoid fever, paratyphoid fever, dysentery (Fu Shi, Boydii, Song Nei Shi), large intestine, distortion, cured sample anthraxs, and sarcina all has inhibitory action (in vitro doubling dilution).
Ilex viridis Champ.: [nature and flavor] are sweet; Micro-pungent; Cool in nature.[return through] heart; Liver Channel.[function cures mainly] removing pathogenic heat from blood and toxic substance from the body.Main burn and scald; Traumatic hemorrhage.[usage and dosage] external: appropriate, fresh goods is smash deposited.
Calamina: [nature and flavor] are sweet is flat.[return through] returns stomach warp.[function cures mainly] removing toxic substances improving acuity of vision and removing nebula, the antipruritic sore of removing dampness.For conjunctival congestion and swelling pain, marginal blepharitis, nebula film bulbar conjunctiva polyp, ulcer being unable to heal, pus is dripping, eczema, skin pruritus.
Radix Paeoniae Rubra: [nature and flavor] are bitter, are slightly cold.[return through] returns Liver Channel.[function cures mainly] clearing away heat and cooling blood, eliminating stasis to stop pain.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, injury from falling down, carbuncle skin infection.
Fructus Xanthii: [nature and flavor] are pungent, bitter, temperature; Poisonous.[return through] returns lung meridian.[function cures mainly] Fructus Xanthii: loose wind dehumidifying, clearing the nasal passage.For headche due to wind-cold, nasal sinusitis watery nasal discharge, rubella pruritus, arthralgia chiefly caused by damp pathogen contracture.Herba Xanthii grass: metrorrhagia, deep abscess, leprosy, skin eczema.
Radix Vitis chungii: [nature and flavor] are sweet; Puckery; Flat.[return through] Liver Channel.[function cures mainly] detumescence and drawing out poison.Main carbuncle sore furuncle and phyma." Xinhua book on Chinese herbal medicine outline ": Herb: sweet in the mouth, puckery, property are put down.There is the function of detumescence and drawing out poison.For carbuncle sore furuncle and phyma.
Herba Duchesneae Indicae: [nature and flavor] are bitter, cool.[function cures mainly] heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.Upper respiratory tract infection, laryngopharynx swelling and pain, oral ulcer, pneumonia, acute enteritis, bacillary dysentery, urinary system infection, orchitis, mastitis, furuncle and phyma skin infection, skin eczema, osteopatia sprain.[pharmacological action] bacteriostatic test: this product decoct, has inhibitory action to hemolytic staphylococcus aureus.
Herba Scutellariae indicae: [nature and flavor] acrid in the mouth; Bitter; Bosom is cold.[return through] GUIXIN; Liver; Lung meridian [function cures mainly] heat-clearing and toxic substances removing; Promoting blood circulation and stopping pain; Hemostasia and detumescence.Main carbuncle furunculosis; Lung abscess; Intestinal carbuncle; Scrofula; Venom; Lung-heat cough with asthma; Toothache; Sore throat; Pharyngalgia; Bones and muscles pain; Spit blood; Spitting of blood; Have blood in stool; Traumatic injury; Wound hemorrhage; Skin pruritus." Quanzhou book on Chinese herbal medicine ": heat-clearing and toxic substances removing, Huang is moved back in detumescence, by blood removing blood stasis with potent drugs, removing pus and relieving carbuncle, cooling blood for hemostasis, throat.Cure mainly all larynxs Huang, also control lung-fire height dyspnea of heat type and cough, spit blood, hemoptysis is spat blood, and crazy blood is had a pain, and knife injury is hemorrhage, malignant boil carbuncle, tiger, lyssodexis.
Radix Celastri Angulati: [nature and flavor] are pungent; Bitter; Cool; Mild toxicity.[return through] lung; Liver; Kidney channel.[function cures mainly] expelling wind and removing dampness; Promoting blood circulation to restore menstrual flow; Removing toxic substances parasite killing.Main air pain of dampness syndrome; Fracture is grieved; Amenorrhea; Skin infection festers; Tinea capitis; Pudendal pruritus." Guizhou medical herbs ": clearing heat for promoting eruption, relaxing muscles and tendons and activating QI and blood in the collateral, regulating menstruation.
Chinese medicinal liquor bandage of the present invention is active component by Herba Senecionis Scandentis, Ilex viridis Champ., Calamina, Radix Paeoniae Rubra, Fructus Xanthii, Radix Vitis chungii, Herba Duchesneae Indicae, Herba Scutellariae indicae, Radix Celastri Angulati or its water and/or its extractive with organic solvent, adds Pioloform, polyvinyl acetal, dibutyl phthalate, methylcellulose, glycerol, laurocapram, ethanol, ethyl acetate make.
Wherein: polyvinyl butyral resin is excellent film forming matter, there is the good transparency, elasticity, pliability, toughness; Methylcellulose can the mixture of water-soluble and organic solvent, is thickening agent, film former, emulsifying agent; Dibutyl phthalate is the most frequently used plasticizer, makes film have good flexibility; Glycerol can skin care, and prevent cracked skin, the water absorption of glycerol to film has a great impact, simultaneously very favourable to wound moisturizing; Laurocapram is the Typical Representative of transdermal enhancer.
A kind of preparation method of Chinese medicinal liquor bandage of the present invention, it comprises the steps: the ethanol extraction secondary Herba Senecionis Scandentis after pulverizing, Ilex viridis Champ., Fructus Xanthii, Herba Scutellariae indicae, Radix Celastri Angulati being added 95%, each 1.5-2.0 hour, collect ethanol extraction filtering residue, merge extractive liquid, being evaporated to ethanol content in 50-60 DEG C (preferably 55 DEG C) is less than 10% (preferably less than 5%), obtains ethanol extraction concentrated solution; Radix Paeoniae Rubra, Radix Vitis chungii, Herba Duchesneae Indicae are decocted with water secondary, collecting decoction together with Herba Senecionis Scandentis, Ilex viridis Champ., Fructus Xanthii, Herba Scutellariae indicae, Radix Celastri Angulati ethanol extraction filtering residue, and filter, concentrating under reduced pressure becomes dry extract, pulverizes and obtains water extract dry extract; Calamine stone is broken into polarity powder; Pioloform, polyvinyl acetal, ethanol are heated while stirring in 40-50 DEG C of water bath with thermostatic control, after material to be filmed dissolves completely, add laurocapram, glycerol, dibutyl phthalate and methylcellulose, mix and blend obtains film liquid; Limit agitated-film liquid, limit adds ethanol extraction concentrated solution, water extract dry extract and Calamina polarity powder with diluted ethyl acetate wherein, namely obtains product after mix homogeneously.
The present invention is further illustrated below by way of related tests.
(1) the comfortableness test of Chinese medicinal liquor bandage of the present invention
With mould, this Chinese medicinal liquor bandage is made the film of 100mm × 20mm size, the thickness surveying difference with micrometer caliper (0.01mm) gets its meansigma methods, then film is placed in the fixture of Tensile Tester, draw speed 300mm/min.Peak load (N) during recording film fracture and extended length (mm).Result of calculation is in table 1.
Table 1: the comfortableness test of the film that Chinese medicinal liquor bandage of the present invention is made
| Sample | Thickness (um) | Percentage elongation (%) | Tensile strength (N/mm 2) |
| Embodiment 1 thin film | 30.5±1.2 | 141.5±2.3 | 5.25±0.46 |
| Embodiment 1 thick film | 63.5±3.1 | 111.7±5.0 | 3.03±1.28 |
| Embodiment 2 thin film | 28.8±0.8 | 135.5±3.3 | 5.08±0.55 |
| Embodiment 3 thin film | 33.5±1.6 | 127.4±3.5 | 4.75±0.87 |
| Embodiment 3 thick film | 60.5±2.6 | 108.5±4.3 | 3.37±1.46 |
Tensile strength and percentage elongation are to film-strength and elastic sign, and result shows that the film that this Chinese medicinal liquor bandage is made can move with skin, are enough to the stress adapting to the generation of health different parts, make people feel comfortable.
(2) Chinese medicinal liquor bandage of the present invention is to the curative effect of rat three phase pressure ulcer
1 material and method
1.1 models: male and healthy SD rat 40, secondary, clean, body weight 185 ± 25g, is divided into matched group and each 20 of observation group at random.After rat abdominal cavity anesthesia, back depilation sterilization, near rat back spinal column on the right side of lower back, the skin holostrome that runs through being 2cm long is deep to fascia transverse incision, will be placed in skin incision through autoclaving magnetic sheet and sew up, magnetic sheet diameter 13cm, thick 2cm, magnetic force 1500Gs.A block external magnet was acted on rat back magnetic sheet implantation region absorption 2h in postoperative 2nd day and cause ischemia, then remove Magnet Shi Gai district SkBF Reperfu-sion 0.5h, this is a circulation, circulation every day 5, repeats 5d.Ischemia, Reperfu-sion total degree 25 times, Ischemia Time amounts to 50h.Using skin darkening, hardening, the not hemorrhage standard as judging ulcer of acupuncture, namely model is successfully prepared.From modeling success next day every day change dressings, matched group gauze carries out route dressing change, experimental group normal saline cleaning wound surface after with the embodiment of the present invention 1 preparation Chinese medicinal liquor bandage change dressings.The single cage of period every rat is raised, and freely drinks water and feed.
1.2 observation index and detection method: observe wound surface area, healing time, wound surface amount of bacteria change.
Within after modeling the 3rd, 7,14,21 day, detect respectively: draw wound surface with copper sulfate paperboard, record wound surface area change, wound healing time (with wound healing 95% for healing standard);
Detect two and form face amount of bacteria change, within the 3rd, 7,14,21 day after modeling, put to death rat wound surface central tissue, extract respectively, weigh under sterile working and add normal saline grinding after, remake 10 times of serial dilutions and get 10ul in culture medium, in 37 DEG C of environment, cultivate 24-48h, using formula calculates every gram of tissue bacterial number.
1.3 statistical methods: measurement data independent samples t-test, ranked data rank test, all statistics are all carried out in SPSS16.0 software.
2 results
2.1 liang of group Rat Wound Healing times compare: often organize each 20 wound surface, observation group's wound healing time (6.67 ± 1.58) d is significantly shorter than matched group (13.46 ± 2.73) d, and difference has statistical significance (P < 0.05).
The change of 2.2 liang of group rat wound surface amount of bacteria is compared: after observation group's modeling, under different time wound surface, amount of bacteria compares with matched group, and difference has statistical significance (P < 0.05).In table 2.
Table 2: amount of bacteria under different time wound surface after two groups of rat modelings (
n=20)
Compare with matched group, * P < 0.05.
Through observation shows that: liquid bandage of the present invention can provide moistening, warm, an airtight low-oxygen environment for wound surface, serves barrier action, effectively can stop bacterial invasion, reduces and infects; And forms the airtight moist environment that applicable granulation tissue grows after contacting with wound surface, can effective wound healing; Good permeability, can the moist degree of active balance wound surface.
(3) clinical observation experiment
1 data and method
1.1 diagnostic criterias: the formulation according to " People's Republic of China's traditional Chinese medicine industry standard--Chinese medical disease Standardization of diagnosis and curative effect (YZ/T001.1-94) " decubital ulcer: be apt to occur in the apophysis such as tail sacrum, ridge, elbow ankle and easily suffer oppression and the position that rubs; From the beginning of skin occurring brown erythema, micro-swollen, purple dark edema then, necrosis is festered; During secondary contamination, tissue necrosis is rapid, and pus is dripping, corresponding site Bing Fa Xing core pain; Be more common in the patient of the prolonged illness beds such as stupor, paralysis, fracture, large-area burns.
1.2 physical data: select III degree, IV degree patients with bedsore 124 example that my institute in December, 2013 in December ,-2014 is accepted for medical treatment, male 74 example, women 50 example, 55 ~ 88 years old age, average (66.4 ± 11.2) year.Decubital ulcer classification: III degree of 84 example, IV degree of 40 example.Symptom: infecting, having pus all appears in wounds.Site of pathological change: tail sacrum portion 64 example, hip 29 example, heel portion 16 example, other position 15 example.Be divided into treatment group and matched group to treat at random, often organize 62 examples, when entering to organize, 2 groups of cases are without significant difference (P > 0.05) in sex, age, decubital ulcer classification, have comparability.
1.3 Therapeutic Method: the equal Cure the Primary Disease of all patients, remove wound surface slough, and clean wound surface, adopts 0.5% iodophor disinfection.The even external application bedsore wound of matched group moist expose burn ointment, exposes treatment; The Chinese medicinal liquor bandage that treatment group is prepared by the embodiment of the present invention 1.2 groups of equal every days change dressings 1 time.All treat two weeks for two groups.
1.4 observation index: all cases are all observed and treated front and treatment the 3rd, 7,14 wound surface areas, wound secretion situation, wound secretion antibacterial culturing.Wherein wound secretion situation is divided into 3 grades: 1 grade of wound surface to heal completely, without secretions according to wound surface feature; 2 grades of wound surface large portion healings, secretions is few, and purulent secretion is few; 3 grades of wound healings are bad, and secretions is more, and based on purulent secretion.
1.5 criterions of therapeutical effect: " Chinese medical disease Standardization of diagnosis and curative effect " evaluation criteria that criterion of therapeutical effect is formulated with reference to State Administration of Traditional Chinese Medicine for 1994 is evaluated: recovery from illness: wound surface all healed, without false healing phenomenons such as empyemas under crust.Effective: wound surface area reduces the scope > 75%, and without purulent secretion, granulation tissue is fresh, and color is scarlet.Effective: wound surface area reduces the scope > 25%, and obviously reduce without purulent secretion or purulent secretion, granulation tissue color is red.Invalid: wound surface area reduces the scope < 25%, wound surface purulent secretion is without obvious minimizing, and granulation tissue color is dark, and wound surface is without obviously reducing trend.Effective percentage=(recovery from illness+effective)/total number of cases × 100%.
1.6 statistical procedures application SPSS16.0 statistical softwares.Measurement data with
represent, and t inspection is adopted to data.P < 0.05 has statistical significance for difference.
2 results
After 2.1 liang of group treatments, effective percentage compares: treatment group effective percentage is 80.6%, apparently higher than 48.4% (P < 0.05) of matched group.In table 3.
Table 3: after two groups of treatments, effective percentage compares, example (%)
Compare with matched group, * P < 0.05.
After 2.2 liang of group treatments, wound surface area change compares: after result display treatment group treats the 3rd, the 7th, the 14th, wound surface area is all less than matched group (P < 0.05).In table 4.
Table 4: two groups treatment after wound surface area change compare (cm2,
)
Compare with matched group, * P < 0.05.
After 2.3 liang of group treatments, secretions situation compares: result shows treatment the 3rd, and treatment group compares with matched group, wound secretions indifference (P > 0.05); After treating the 7th, 14, treatment group secretions reduces situation and is obviously better than matched group (P < 0.05).In table 5.
Table 5: secretions situation and antibacterial culturing situation after two groups of treatments
Compare with matched group, * P < 0.05.
After 2.4 liang of group treatments, secretions antibacterial culturing situation compares: result shows that treatment is after the 3rd, the 7th, 14, and treatment group secretions positive rate of bacteria is starkly lower than matched group (P < 0.05).In table 5.
Clinical practice confirms, liquid wound of the present invention is attached to treatment decubital ulcer concurrent infection aspect and has greater advantages, and it can form protective layer at wound surface, effectively can isolate the contact of wound surface and external environment, destroys the environment of bacterial growth, breeding; Antimicrobial component containing multiple wide spectrum, can play anti-infectious function: improve microcirculation and histanoxia simultaneously, accelerates tissue repair, thus wound healing time is shortened dramatically.
In a word, the present invention has following beneficial effect: the present invention 9 taste Chinese medicine promotes mutually, interacts, effect of heat-clearing and toxic substances removing, anti-inflammation detumescence, blood circulation promoting and blood stasis dispelling, putrefaction removing and tissue regeneration promoting is had combined into it, can the Growth and reproduction of effective infection control pathogen, improve microcirculation around wound surface simultaneously, increase regional flow, promote granulation tissue growth, accelerate healing.Its use is comfortable, convenient, not by the restriction at shape of wound, size, residing position, simultaneously water proof, good permeability, be not stained with clothing cotton-padded mattress, do not produce anaphylaxis and drug resistance.
Detailed description of the invention
Further describe the present invention below by way of detailed description of the invention, but the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the present invention is suitably improved, replaces the identical component of effect, will become apparent to those skilled in the art that they are all deemed to be included within scope of the present invention.
Embodiment 1
Prescription:
Medical material: Herba Senecionis Scandentis 20 parts, Ilex viridis Champ. 18 parts, Calamina 3.5 parts, Radix Paeoniae Rubra 10 parts, Fructus Xanthii 6 parts, Radix Vitis chungii 13 parts, Herba Duchesneae Indicae 12 parts, Herba Scutellariae indicae 15 parts, Radix Celastri Angulati 9 parts;
Adjuvant: Pioloform, polyvinyl acetal 33 parts, dibutyl phthalate 7 parts, methylcellulose 4.5 parts, glycerol 12 parts, laurocapram 12 parts, ethanol 170 parts, ethyl acetate 45 parts.
Preparation method: the Herba Senecionis Scandentis after pulverizing, Ilex viridis Champ., Fructus Xanthii, Herba Scutellariae indicae, Radix Celastri Angulati are added the ethanol extraction secondary of 95%, each 1.5-2.0 hour, collects ethanol extraction filtering residue, merge extractive liquid, being evaporated to ethanol content in 55 DEG C is 4.5%, obtains ethanol extraction concentrated solution; Radix Paeoniae Rubra, Radix Vitis chungii, Herba Duchesneae Indicae are decocted with water secondary, collecting decoction together with Herba Senecionis Scandentis, Ilex viridis Champ., Fructus Xanthii, Herba Scutellariae indicae, Radix Celastri Angulati ethanol extraction filtering residue, and filter, concentrating under reduced pressure becomes dry extract, pulverizes and obtains water extract dry extract; Calamine stone is broken into polarity powder; Pioloform, polyvinyl acetal, ethanol are heated while stirring in 45 DEG C of waters bath with thermostatic control, after material to be filmed dissolves completely, add laurocapram, glycerol, dibutyl phthalate and methylcellulose, mix and blend obtains film liquid; Limit agitated-film liquid, limit adds ethanol extraction concentrated solution, water extract dry extract and Calamina polarity powder with diluted ethyl acetate wherein, namely obtains product after mix homogeneously.
Embodiment 2
Prescription:
Medical material: Herba Senecionis Scandentis 23 parts, Ilex viridis Champ. 20 parts, Calamina 4.0 parts, Radix Paeoniae Rubra 10 parts, Fructus Xanthii 5 parts, Radix Vitis chungii 15 parts, Herba Duchesneae Indicae 14 parts, Herba Scutellariae indicae 15 parts, Radix Celastri Angulati 10 parts;
Adjuvant: Pioloform, polyvinyl acetal 35 parts, dibutyl phthalate 8 parts, methylcellulose 4.5 parts, glycerol 10 parts, laurocapram 10 parts, ethanol 180 parts, ethyl acetate 45 parts.
Preparation method: the Herba Senecionis Scandentis after pulverizing, Ilex viridis Champ., Fructus Xanthii, Herba Scutellariae indicae, Radix Celastri Angulati are added the ethanol extraction secondary of 95%, each 1.5-2.0 hour, collects ethanol extraction filtering residue, merge extractive liquid, being evaporated to ethanol content in 50 DEG C is 4.0%, obtains ethanol extraction concentrated solution; Radix Paeoniae Rubra, Radix Vitis chungii, Herba Duchesneae Indicae are decocted with water secondary, collecting decoction together with Herba Senecionis Scandentis, Ilex viridis Champ., Fructus Xanthii, Herba Scutellariae indicae, Radix Celastri Angulati ethanol extraction filtering residue, and filter, concentrating under reduced pressure becomes dry extract, pulverizes and obtains water extract dry extract; Calamine stone is broken into polarity powder; Pioloform, polyvinyl acetal, ethanol are heated while stirring in 47 DEG C of waters bath with thermostatic control, after material to be filmed dissolves completely, add laurocapram, glycerol, dibutyl phthalate and methylcellulose, mix and blend obtains film liquid; Limit agitated-film liquid, limit adds ethanol extraction concentrated solution, water extract dry extract and Calamina polarity powder with diluted ethyl acetate wherein, namely obtains product after mix homogeneously.
Embodiment 3
Prescription:
Medical material: Herba Senecionis Scandentis 30 parts, Ilex viridis Champ. 15 parts, Calamina 5 parts, Radix Paeoniae Rubra 12 parts, Fructus Xanthii 8 parts, Radix Vitis chungii 15 parts, Herba Duchesneae Indicae 15 parts, Herba Scutellariae indicae 13 parts, Radix Celastri Angulati 12 parts;
Adjuvant: Pioloform, polyvinyl acetal 40 parts, dibutyl phthalate 7 parts, methylcellulose 4.5 parts, glycerol 12 parts, laurocapram 12 parts, ethanol 180 parts, ethyl acetate 45 parts.
Preparation method: the Herba Senecionis Scandentis after pulverizing, Ilex viridis Champ., Fructus Xanthii, Herba Scutellariae indicae, Radix Celastri Angulati are added the ethanol extraction secondary of 95%, each 1.5-2.0 hour, collects ethanol extraction filtering residue, merge extractive liquid, being evaporated to ethanol content in 60 DEG C is 4.5%, obtains ethanol extraction concentrated solution; Radix Paeoniae Rubra, Radix Vitis chungii, Herba Duchesneae Indicae are decocted with water secondary, collecting decoction together with Herba Senecionis Scandentis, Ilex viridis Champ., Fructus Xanthii, Herba Scutellariae indicae, Radix Celastri Angulati ethanol extraction filtering residue, and filter, concentrating under reduced pressure becomes dry extract, pulverizes and obtains water extract dry extract; Calamine stone is broken into polarity powder; Pioloform, polyvinyl acetal, ethanol are heated while stirring in 42 DEG C of waters bath with thermostatic control, after material to be filmed dissolves completely, add laurocapram, glycerol, dibutyl phthalate and methylcellulose, mix and blend obtains film liquid; Limit agitated-film liquid, limit adds ethanol extraction concentrated solution, water extract dry extract and Calamina polarity powder with diluted ethyl acetate wherein, namely obtains product after mix homogeneously.
Embodiment 4
Prescription:
Medical material: Herba Senecionis Scandentis 15 parts, Ilex viridis Champ. 20 parts, Calamina 3.5 parts, Radix Paeoniae Rubra 10 parts, Fructus Xanthii 6 parts, Radix Vitis chungii 15 parts, Herba Duchesneae Indicae 10 parts, Herba Scutellariae indicae 10 parts, Radix Celastri Angulati 9 parts;
Adjuvant: Pioloform, polyvinyl acetal 30 parts, dibutyl phthalate 7 parts, methylcellulose 3.5 parts, glycerol 8 parts, laurocapram 10 parts, ethanol 150 parts, ethyl acetate 30 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 5
Prescription:
Medical material: Herba Senecionis Scandentis 20 parts, Ilex viridis Champ. 20 parts, Calamina 4.5 parts, Radix Paeoniae Rubra 12 parts, Fructus Xanthii 8 parts, Radix Vitis chungii 13 parts, Herba Duchesneae Indicae 15 parts, Herba Scutellariae indicae 10 parts, Radix Celastri Angulati 10 parts;
Adjuvant: Pioloform, polyvinyl acetal 35 parts, dibutyl phthalate 9 parts, methylcellulose 3 parts, glycerol 10 parts, laurocapram 10 parts, ethanol 170 parts, ethyl acetate 35 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 6
Prescription:
Medical material: Herba Senecionis Scandentis 25 parts, Ilex viridis Champ. 15 parts, Calamina 4.5 parts, Radix Paeoniae Rubra 12 parts, Fructus Xanthii 10 parts, Radix Vitis chungii 13 parts, Herba Duchesneae Indicae 15 parts, Herba Scutellariae indicae 14 parts, Radix Celastri Angulati 10 parts;
Adjuvant: Pioloform, polyvinyl acetal 35 parts, dibutyl phthalate 8 parts, methylcellulose 4.0 parts, glycerol 15 parts, laurocapram 12 parts, ethanol 175 parts, ethyl acetate 40 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 7
Prescription:
Medical material: Herba Senecionis Scandentis 30 parts, Ilex viridis Champ. 25 parts, Calamina 6 parts, Radix Paeoniae Rubra 15 parts, Fructus Xanthii 12 parts, Radix Vitis chungii 16 parts, Herba Duchesneae Indicae 15 parts, Herba Scutellariae indicae 20 parts, Radix Celastri Angulati 12 parts;
Adjuvant: Pioloform, polyvinyl acetal 37 parts, dibutyl phthalate 9 parts, methylcellulose 5.5 parts, glycerol 15 parts, laurocapram 15 parts, ethanol 195 parts, ethyl acetate 50 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 8
Prescription:
Medical material: Herba Senecionis Scandentis 25 parts, Ilex viridis Champ. 20 parts, Calamina 3 parts, Radix Paeoniae Rubra 9 parts, Fructus Xanthii 5 parts, Radix Vitis chungii 12 parts, Herba Duchesneae Indicae 11 parts, Herba Scutellariae indicae 15 parts, Radix Celastri Angulati 12 parts;
Adjuvant: Pioloform, polyvinyl acetal 33 parts, dibutyl phthalate 7 parts, methylcellulose 4.5 parts, glycerol 12 parts, laurocapram 12 parts, ethanol 170 parts, ethyl acetate 45 parts.
Preparation method: carry out with reference to embodiment 1.
Claims (7)
1. a prevention, treatment decubital ulcer merge the Chinese medicinal liquor bandage of bacteriological infection, it is characterized in that being made up of following Chinese crude drug and adjuvant, described Chinese crude drug is: Herba Senecionis Scandentis, Ilex viridis Champ., Calamina, Radix Paeoniae Rubra, Fructus Xanthii, Radix Vitis chungii, Herba Duchesneae Indicae, Herba Scutellariae indicae, Radix Celastri Angulati;
Described adjuvant is: Pioloform, polyvinyl acetal 30-40 part, dibutyl phthalate 6-9 part, methylcellulose 2-6 part, glycerol 7.5-18 part, laurocapram 10-15 part, ethanol 150-200 part, ethyl acetate 30-50 part.
Wherein, solid constituent with the corresponding relation of liquid components is: solid part unit is liquid part unit that g is corresponding is mL, or solid part unit be liquid part unit that Kg is corresponding is L.
2. Chinese medicinal liquor bandage as claimed in claim 1, is characterized in that the weight of described Chinese crude drug is: Herba Senecionis Scandentis 15-30 part, Ilex viridis Champ. 15-30 part, Calamina 3-6 part, Radix Paeoniae Rubra 9-15 part, Fructus Xanthii 5-15 part, Radix Vitis chungii 9-17 part, Herba Duchesneae Indicae 6-18 part, Herba Scutellariae indicae 10-20 part, Radix Celastri Angulati 5-15 part.
3. Chinese medicinal liquor bandage as claimed in claim 2, is characterized in that the weight of described Chinese crude drug is: Herba Senecionis Scandentis 20-25 part, Ilex viridis Champ. 18-23 part, Calamina 3-6 part, Radix Paeoniae Rubra 9-12 part, Fructus Xanthii 5-8 part, Radix Vitis chungii 12-15 part, Herba Duchesneae Indicae 11-15 part, Herba Scutellariae indicae 13-18 part, Radix Celastri Angulati 8-13 part.
4. Chinese medicinal liquor bandage as claimed in claim 3, is characterized in that the weight of described Chinese crude drug is preferably: Herba Senecionis Scandentis 20 parts, Ilex viridis Champ. 18 parts, Calamina 3.5 parts, Radix Paeoniae Rubra 10 parts, Fructus Xanthii 6 parts, Radix Vitis chungii 13 parts, Herba Duchesneae Indicae 12 parts, Herba Scutellariae indicae 15 parts, Radix Celastri Angulati 9 parts;
5. Chinese medicinal liquor bandage as claimed in claim 4, is characterized in that the weight of described adjuvant is preferably: Pioloform, polyvinyl acetal 33 parts, dibutyl phthalate 7 parts, methylcellulose 4.5 parts, glycerol 12 parts, laurocapram 12 parts, ethanol 170 parts, ethyl acetate 45 parts.
6. the Chinese medicinal liquor bandage as described in claim 1-5, it is characterized in that by Herba Senecionis Scandentis, Ilex viridis Champ., Calamina, Radix Paeoniae Rubra, Fructus Xanthii, Radix Vitis chungii, Herba Duchesneae Indicae, Herba Scutellariae indicae, Radix Celastri Angulati or its water and/or its extractive with organic solvent be active component, add Pioloform, polyvinyl acetal, dibutyl phthalate, methylcellulose, glycerol, laurocapram, ethanol, ethyl acetate make.
7. the Chinese medicinal liquor bandage as described in claim 1-6, it is characterized in that preparation method comprises the steps: the Herba Senecionis Scandentis after pulverizing, Ilex viridis Champ., Fructus Xanthii, Herba Scutellariae indicae, Radix Celastri Angulati to add the ethanol extraction secondary of 95%, each 1.5-2.0 hour, collect ethanol extraction filtering residue, merge extractive liquid, being evaporated to ethanol content in 50-60 DEG C (preferably 55 DEG C) is less than 10% (preferably less than 5%), obtains ethanol extraction concentrated solution; Radix Paeoniae Rubra, Radix Vitis chungii, Herba Duchesneae Indicae are decocted with water secondary, collecting decoction together with Herba Senecionis Scandentis, Ilex viridis Champ., Fructus Xanthii, Herba Scutellariae indicae, Radix Celastri Angulati ethanol extraction filtering residue, and filter, concentrating under reduced pressure becomes dry extract, pulverizes and obtains water extract dry extract; Calamine stone is broken into polarity powder; Pioloform, polyvinyl acetal, ethanol are heated while stirring in 40-50 DEG C of water bath with thermostatic control, after material to be filmed dissolves completely, add laurocapram, glycerol, dibutyl phthalate and methylcellulose, mix and blend obtains film liquid; Limit agitated-film liquid, limit adds ethanol extraction concentrated solution, water extract dry extract and Calamina polarity powder with diluted ethyl acetate wherein, namely obtains product after mix homogeneously.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510562683.4A CN105168638A (en) | 2015-09-07 | 2015-09-07 | Traditional Chinese medicinal liquid band aid for preventing and treating bedsore complicated with bacterial infection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510562683.4A CN105168638A (en) | 2015-09-07 | 2015-09-07 | Traditional Chinese medicinal liquid band aid for preventing and treating bedsore complicated with bacterial infection |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105816908A (en) * | 2016-04-29 | 2016-08-03 | 哈尔滨乾佰纳生物药业有限公司 | Waterproof liquid wound protection film and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101920042A (en) * | 2010-07-16 | 2010-12-22 | 四川理工学院 | Liquid bandage and preparation method |
-
2015
- 2015-09-07 CN CN201510562683.4A patent/CN105168638A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101920042A (en) * | 2010-07-16 | 2010-12-22 | 四川理工学院 | Liquid bandage and preparation method |
Non-Patent Citations (1)
| Title |
|---|
| 李特，等。: ""中西医治疗褥疮的研究进展"", 《中国老年保健医学》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105816908A (en) * | 2016-04-29 | 2016-08-03 | 哈尔滨乾佰纳生物药业有限公司 | Waterproof liquid wound protection film and preparation method thereof |
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Application publication date: 20151223 |