CN117045745A - Traditional Chinese medicine composition for treating anal fissure - Google Patents
Traditional Chinese medicine composition for treating anal fissure Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating anal fissure, which is prepared from the following raw materials in parts by weight: 10-30 parts of coptis chinensis, 10-30 parts of rhizoma bletillae, 10-30 parts of dragon's blood, 10-30 parts of gallnut, 10-30 parts of frankincense, 10-30 parts of myrrh, 10-20 parts of catechu, 10-20 parts of radix angelicae, 10-20 parts of red paeony root, 5-10 parts of liquorice and 5-10 parts of borneol. The composition has precise and appropriate compatibility, and can effectively improve symptoms such as pain, hematochezia, long-term non-healing wound surface and the like of anal fissure, thereby improving the treatment effect of the anal fissure.
Description
Technical Field
The invention particularly relates to a traditional Chinese medicine composition for treating anal fissure.
Background
Anal fissure is first proposed by Lockhart-Mummery in 1934, is longitudinal tearing of anal canal skin layers below dentate lines, is a common anorectal disease, has prevalence of 4% -6% for people, and is clinically mainly manifested by bleeding during and after defecation and periodic pain of anus. The etiology and pathology of anal fissure are mainly that the internal sphincter of anus spasms to cause poor perianal blood circulation, and the malignant circulation of ischemia-spasms-ischemia is caused, and finally anal canal longitudinal or spindle-shaped ischemic ulcers are caused to form anal fissure.
Anal fissure traditional Chinese medicine belongs to the categories of hemorrhoids of hooked intestines, hemorrhoids of split glands and anal hemorrhoids, and each family analyzes the etiology and pathogenesis of the anal fissure from the aspects of yin and yang, essence, qi, blood, body fluid, channels and collaterals and the like, and mainly comprises constipation caused by heat of blood and dryness of intestines, defecation and struggle; or damp-heat accumulation and contamination; or the local qi and blood stasis of the long-term illness and the meridian obstruction; or yin deficiency and fluid deficiency, and skin failing to nourish the skin, which eventually leads to perianal skin lacerations. The anal fissure can be classified as acute or chronic, the symptoms of the acute anal fissure last for no more than 6-8 weeks, most of the acute anal fissure is effective in a conservation treatment, but about 50% of patients with the acute anal fissure are converted into chronic anal fissure after long-time conservation treatment, and pain and chronic anal fissure are not healed, so that physical and mental health and life quality of the patients are seriously affected.
At present, a plurality of traditional Chinese medicine formulas for treating anal fissure, such as Beijing Wanhong hemorrhoids ointment with the effects of clearing heat and detoxicating, removing blood stasis and relieving pain and astringing and stopping bleeding. Although it can treat anal fissure, the ingredients of the medicine are complex, the cost is high, and it is necessary to develop a traditional Chinese medicine composition which has more simplified medicine composition and can maintain good curative effect to treat anal fissure.
Disclosure of Invention
In order to solve the problems, the invention provides a traditional Chinese medicine composition for treating anal fissure, which is prepared from the following raw materials in parts by weight:
10-30 parts of coptis chinensis, 10-30 parts of rhizoma bletillae, 10-30 parts of dragon's blood, 10-30 parts of gallnut, 10-30 parts of frankincense, 10-30 parts of myrrh, 10-20 parts of catechu, 10-20 parts of radix angelicae, 10-20 parts of red paeony root, 5-10 parts of liquorice and 5-10 parts of borneol.
Further, the material is prepared from the following raw materials in parts by weight:
30 parts of coptis chinensis, 30 parts of rhizoma bletillae, 30 parts of dragon's blood, 30 parts of gallnut, 30 parts of frankincense, 30 parts of myrrh, 20 parts of catechu, 20 parts of radix angelicae, 20 parts of red paeony root, 10 parts of liquorice and 10 parts of borneol.
Still further, the licorice is licorice.
Further, the preparation is prepared by taking medicinal powder of the raw material medicine or water or organic solvent extract of the raw material medicine as an active ingredient and adding pharmaceutically acceptable auxiliary materials.
Further, the preparation is an external preparation; the external preparation is in form of solution, ointment, gel, patch, preferably ointment.
The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps:
(1) Weighing the raw materials according to the proportion;
(2) Grinding the raw materials into powder, or extracting with water or organic solvent, and adding pharmaceutically acceptable adjuvants or auxiliary components.
Further, adding hot melt vaseline into the powder obtained in the step (2), and uniformly mixing to obtain the product.
The invention finally provides application of the traditional Chinese medicine composition in preparing medicines for treating anal fissure.
Further, the medicine has the effects of relieving pain, stopping bleeding, healing sore and promoting granulation.
The invention starts from the theory of traditional Chinese medicine, and provides a treatment method for clearing heat and promoting diuresis, removing toxin and removing blood stasis, stopping bleeding and promoting granulation aiming at four pathogenesis of damp, heat, blood stasis and toxin under the guidance of the theory of traditional Chinese medicine integral concept, and provides a traditional Chinese medicine composition capable of rapidly relieving symptoms such as anal fissure pain, hematochezia, long-term non-healing wound surface and the like and a preparation method thereof. The clinical application achieves satisfactory clinical curative effect.
The composition takes coptis chinensis, dragon's blood, rhizoma bletillae as monarch, red paeony root, chinese gall, frankincense and myrrh as ministers, dahurian angelica root and catechu as assistants, borneol and raw licorice as guides. "Huangdi's internal channels" indicates that all pain and itch sores belong to the heart, so that coptis root in the recipe enters the heart channel to clear heat and dry dampness, purge fire and detoxify; the "Huangdi's internal channel plain question and five viscera generation" indicates that all blood-vessels belong to the heart, so the recipe is to remove blood stasis and relieve pain, stop bleeding and promote tissue regeneration with dragon's blood. The bletilla striata has good effect of astringing and stopping bleeding, and detumescence and promoting granulation, and is used for treating sore pain, and is mainly used for treating chronic ulcer without healing. The three medicines of coptis chinensis, dragon's blood and rhizoma bletillae are combined, and the medicine is directly designed for the pathogenesis of dampness, heat, blood stasis and toxin, has good effects of relieving pain, stopping bleeding, healing sore and promoting granulation, and achieves the effect of treating both principal and secondary aspects of disease.
The radix paeoniae rubra has the effects of clearing heat and cooling blood, removing stasis and relieving pain, and the radix glycyrrhizae is the radix paeoniae alba and liquorice soup, so that the radix paeoniae alba and liquorice soup has remarkable effect of relieving spasm. Galla chinensis has effects of astringing lung, lowering fire, stopping bleeding, eliminating dampness, and healing sore. The olibanum has the effects of activating blood circulation to stop pain, and the myrrh has the effects of removing blood stasis to stop pain, relieving swelling and promoting tissue regeneration, and is mainly used for treating the chronic sores without astringing the mouth. Radix angelicae can dispel wind and remove dampness, promote resuscitation and relieve pain, reduce swelling and drain pus. Catechu has the actions of astringing dampness and promoting tissue regeneration and healing sore. Borneol has the effects of inducing resuscitation and refreshing mind, and clearing heat and relieving pain. The raw licorice root has the effects of clearing heat and detoxicating, relieving spasm and pain and harmonizing medicine property. The whole formula has the effects of clearing heat and promoting diuresis, removing toxin and removing blood stasis, stopping bleeding and promoting granulation.
The composition has precise compatibility, can effectively improve symptoms such as anal fissure pain, hematochezia, long-term non-healing wound surface and the like, greatly improves the treatment effect of anal fissure, has no toxic or side effect, is a safe and effective traditional Chinese medicine composition for treating anal fissure, and has good application prospect.
It should be apparent that, in light of the foregoing, various modifications, substitutions and alterations can be made herein without departing from the spirit and scope of the invention as defined by the appended claims.
The above-described aspects of the present invention will be described in further detail below with reference to specific embodiments in the form of examples. It should not be understood that the scope of the above subject matter of the present invention is limited to the following examples only. All techniques implemented based on the above description of the invention are within the scope of the invention.
Detailed Description
EXAMPLE 1 preparation of the composition of the invention
The formula comprises the following components: 30g of coptis chinensis, 30g of rhizoma bletillae, 30g of dragon's blood, 30g of Chinese gall, 30g of frankincense, 30g of myrrh, 20g of catechu, 20g of radix angelicae, 20g of red paeony root, 10g of raw liquorice and 10g of borneol.
The preparation method comprises the following steps:
(1) weighing the traditional Chinese medicine decoction pieces according to the proportion, and crushing the decoction pieces into superfine powder for standby; heating vaseline in water bath to 70-80 deg.c to melt completely and heat the vaseline;
(2) gradually adding the powder in the step (1) into melted Vaseline matrix by using a melting method, and according to the powder: the substrates are mixed and stirred in a beaker according to the proportion of 1:2, and the temperature is kept at 70-80 ℃ until the substrates are fully mixed and condensed to form semisolid ointment. If the ointment is not fine, grinding with grinder to make it into gravel without particles to obtain ointment.
The using method comprises the following steps: the anal fissure is sterilized by local iodophor and then is dipped to dryness, the prepared ointment is evenly coated on the anal fissure wound surface by a sterile cotton swab, the medicine is changed for 2 times in 1 day, and the excrement and urine are emptied before the medicine is applied.
EXAMPLE 2 preparation of the medicament of the invention
The formula comprises the following components: 20g of coptis chinensis, 20g of rhizoma bletillae, 20g of dragon's blood, 20g of gallnut, 20g of frankincense, 20g of myrrh, 15g of catechu, 15g of radix angelicae, 10g of red paeony root, 8g of raw liquorice and 8g of borneol.
The preparation method comprises the following steps: same as in example 1
EXAMPLE 3 preparation of the medicament of the invention
The formula comprises the following components: 15g of coptis chinensis, 15g of rhizoma bletillae, 15g of dragon's blood, 15g of gallnut, 15g of frankincense, 15g of myrrh, 12g of catechu, 12g of radix angelicae, 12g of red paeony root, 6g of raw liquorice and 6g of borneol.
The preparation method comprises the following steps: same as in example 1
EXAMPLE 4 preparation of the medicament of the invention
The formula comprises the following components: 10g of coptis chinensis, 10g of rhizoma bletillae, 10g of dragon's blood, 10g of Chinese gall, 10g of frankincense, 10g of myrrh, 10g of catechu, 10g of radix angelicae, 10g of red paeony root, 5g of raw liquorice and 5g of borneol.
The preparation method comprises the following steps: same as in example 1
The beneficial effects of the present invention are described below by test examples
Test example 1 clinical study
1. Clinical data
80 acute anal fissure patients who are collected and treated by 2022, 1 month and 2023, 5 months of traditional Chinese medicine hospitals in south China are selected and randomly divided into 40 observation groups and 40 control groups. The basic data of the two groups of gender, age, disease course, stage and the like have no statistical significance (P is more than 0.05) and are comparable. The study was approved by the medical ethics committee of hospitals.
2. Therapeutic method
Before administration, the health of the patient is announced, anxiety is avoided, and the patient is guided to eat reasonably; if a patient with severe constipation is present, the patient is interfered with an oral cathartic medicine (polyethylene glycol 4000 powder) until the stool is smooth. After the anal fissure is disinfected by local iodophor and then is dipped to be dry, the observation group uses a sterile cotton swab to uniformly apply the prepared ointment on the anal fissure wound surface in a proper amount according to the embodiment 1. The control group uses sterile cotton swab to uniformly apply the right amount of Beijing Wanhong hemorrhoid ointment on anal fissure wound surface. All patients are emptied and relieve the bowels before taking medicine, and the medicine is changed for 2 times in 1 day, and 2 weeks are taken as a treatment course. Other drugs (other than cathartic) for treating anal fissure are deactivated during the treatment period. Statistical observations of 1 course of treatment.
3. Observation index and therapeutic effect determination
3.1 symptomatic control cases: pain relief time, hematochezia disappearance time, anal fissure healing time.
3.2 overall efficacy judgment: with reference to the standard of efficacy of anal fissures approved by the national medical administration:
and (3) healing: anal fissure heals and the symptoms of hematochezia and anal pain disappear;
improvement: anal fissure is reduced, hematochezia and anal pain are relieved;
the method is characterized in that: the anal fissure has no change and symptoms are not improved.
The effective rate of the two groups of treatments was calculated, the effective rate= (number of cure cases+number of improvement cases)/total number of cases, and the two groups of effective rates were compared by statistics.
4. Statistical method
Data processing and metering data using SPSS25.0 softwareIt is statistically significant that the counts are expressed as examples (n) and percent (%) using the t-test and that P < 0.05 is the difference using the χ2 test.
5. Results
5.1 comparison of total effective rates of two groups of treatments: the total effective rate of the observed group treatment is 100%, which is higher than 77.5% of that of the control group, and the difference has statistical significance (P < 0.05), as shown in Table 1.
Table 1 comparison of clinical efficacy after treatment for two groups of patients (n=40, example)
* Comparison with control group P < 0.05
5.2 comparison of two sets of symptom control conditions: the pain relief time, the blood disappearance time and the anal fissure healing time of the observation group are shorter than those of the control group, and the difference has statistical significance (P is less than 0.05), as shown in Table 2
Table 2 two sets of symptom control cases were compared (n=40,)
* Comparison with control group P < 0.05
Conclusion the results of this study showed that: the total effective rate of the observed group treatment is 100%, which is higher than 77.5% of that of the control group, and the difference has statistical significance (P < 0.05). The pain relieving time, the hematochezia disappearing time and the anal fissure healing time of the observation group are shorter than those of the control group, and the difference has statistical significance (P is less than 0.05). The traditional Chinese medicine combination medicine is used for treating, so that symptoms such as pain, hematochezia, long-term non-healing wound surface and the like of anal fissure can be effectively improved, and the treatment effect of the anal fissure is improved.
Claims (9)
1. A traditional Chinese medicine composition for treating anal fissure is characterized in that: the material is prepared from the following raw materials in parts by weight:
10-30 parts of coptis chinensis, 10-30 parts of rhizoma bletillae, 10-30 parts of dragon's blood, 10-30 parts of gallnut, 10-30 parts of frankincense, 10-30 parts of myrrh, 10-20 parts of catechu, 10-20 parts of radix angelicae, 10-20 parts of red paeony root, 5-10 parts of liquorice and 5-10 parts of borneol.
2. The traditional Chinese medicine composition according to claim 1, wherein: the material is prepared from the following raw materials in parts by weight:
30 parts of coptis chinensis, 30 parts of rhizoma bletillae, 30 parts of dragon's blood, 30 parts of gallnut, 30 parts of frankincense, 30 parts of myrrh, 20 parts of catechu, 20 parts of radix angelicae, 20 parts of red paeony root, 10 parts of liquorice and 10 parts of borneol.
3. The traditional Chinese medicine composition according to claim 2, wherein: the licorice is licorice.
4. A Chinese medicinal composition according to any one of claims 1 to 3, characterized in that: the preparation is prepared by taking medicinal powder of the raw materials or water or organic solvent extracts of the raw materials as active ingredients and adding pharmaceutically acceptable auxiliary materials.
5. The traditional Chinese medicine composition according to claim 4, wherein: the preparation is an external preparation; the external preparation is in form of solution, ointment, gel, patch, preferably ointment.
6. The method for preparing the traditional Chinese medicine composition according to any one of claims 1 to 5, which is characterized in that: it comprises the following steps:
(1) Weighing raw materials according to the proportion of claim 1;
(2) Grinding the raw materials into powder, or extracting with water or organic solvent, and adding pharmaceutically acceptable adjuvants or auxiliary components.
7. The traditional Chinese medicine composition according to claim 4, wherein: and (3) adding hot melt vaseline into the powder in the step (2), and uniformly mixing to obtain the product.
8. Use of the traditional Chinese medicine composition according to any one of claims 1-5 in the preparation of a medicament for treating anal fissure.
9. Use according to claim 8, characterized in that: the medicine has effects of relieving pain, stopping bleeding, healing sore and promoting granulation.
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