CN102920800B - Topical drug composite and application and preparation method thereof - Google Patents
Topical drug composite and application and preparation method thereof Download PDFInfo
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- CN102920800B CN102920800B CN201210445314.3A CN201210445314A CN102920800B CN 102920800 B CN102920800 B CN 102920800B CN 201210445314 A CN201210445314 A CN 201210445314A CN 102920800 B CN102920800 B CN 102920800B
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Abstract
The invention discloses a topical drug composite, and the formula comprises: by weight, 15-20 parts of rhizoma coptidis, 15-50 parts of radix scutellariae, 20-30 parts of lithospermum, 15-25 parts of safflower carthamus, 15-20 parts of myrrh, 15-50 parts of raw rhubarb, 50-100 parts of pseudo-ginseng, 15-50 parts of polygonum cuspidatum, 40-70 parts of zinc oxide, 0.8 part of anisodamine, 150 parts of borneol and 320-380 parts of sesame oil. The invention further discloses application of the topical drug composite in the preparation of drugs treating skin injury which comprises skin burn, skin scald, skin ambustion, skin lesions caused by radiation and chemotherapy, bedsore, and skin fester caused by other reasons.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of new externally-applied medicinal composition and application and preparation method.
Background technology
After burn, patient is agonizing, can make skin barrier function be damaged from pathology burn, and the slough due to burn is the good culture medium of antibacterial, and burn wound is also one of important sources causing systemic infection.Burn wound's medicine for external use can be protected wound surface, protects from infection, wound healing.People constantly seek new external use burn treating medicine for many years, to reach the therapeutic purposes of expection, fast and effeciently remove patient's misery.At present, conventional external use burn treating medicine is of a great variety both at home and abroad, has certain curative effect, but also has certain deficiency, and its therapeutic effect still can not be satisfactory.
Summary of the invention
The externally-applied medicinal composition that the object of this invention is to provide a kind of short treating period, instant effect, high safety, wound repair effect is good, the rear cicatrix of healing is few, has no side effect.Externally-applied medicinal composition of the present invention is applicable to various burnings, scald, burn, put (change) treats skin injury caused and skin ulceration, pressure ulcer etc.
The present invention solves the problems of the technologies described above taked technical scheme:
A kind of externally-applied medicinal composition, formula comprises ():
Rhizoma Coptidis 15-50 weight portion, Radix Scutellariae 15-50 weight portion, Radix Arnebiae (Radix Lithospermi) 20-30 weight portion, Flos Carthami 15-25 weight portion, Myrrha 15-20 weight portion, Radix Et Rhizoma Rhei 15-50 weight portion, Radix Notoginseng 50-100 weight portion, Rhizoma Polygoni Cuspidati 15-50 weight portion, zinc oxide 40-70 weight portion, Anisodamine 0.8 weight portion, Borneolum Syntheticum 150 weight portions, Oleum sesami 320-380 weight portion.
Preferred formula is:
Rhizoma Coptidis 15 weight portions, Radix Scutellariae 15 weight portions, Radix Arnebiae (Radix Lithospermi) 20 weight portions, Flos Carthami 15 weight portions, Myrrha 20 weight portions, Radix Et Rhizoma Rhei 15 weight portions, Radix Notoginseng 50 weight portions, Rhizoma Polygoni Cuspidati 15 weight portions, zinc oxide 40 weight portions, Anisodamine 0.8 weight portion, Borneolum Syntheticum 150 weight portions, Oleum sesami 320-380 weight portion.
Another object of the present invention is to provide the application of described externally-applied medicinal composition in the medicine of preparation treatment skin injury, and described skin injury comprises the skin ulceration that skin burn, skin scald, skin burn, caused by radiotherapy and chemotherapy skin injury, decubital ulcer, other reasons cause.
A further object of the invention, is to provide the preparation method of described externally-applied medicinal composition, and its preparation process is:
I. according to formula, get various raw materials;
II., after Rhizoma Coptidis, Radix Scutellariae, Radix Arnebiae (Radix Lithospermi), Flos Carthami, Radix Et Rhizoma Rhei, Radix Notoginseng clean up respectively, be ground into 80-100 object fine powder, stand-by; After Myrrha sterilizing, be ground into 80-100 order fine powder, stand-by; Zinc oxide, Anisodamine and Borneolum Syntheticum, be ground into 80-100 object fine powder, stand-by;
III. the fine powder of described Rhizoma Coptidis, Radix Scutellariae, Radix Arnebiae (Radix Lithospermi), Flos Carthami, Radix Et Rhizoma Rhei and Radix Notoginseng is joined in Oleum sesami oil and soaked 12 hours, then the medicine of immersion and Oleum sesami are heated to 120
oc is also incubated 20 minutes, the little fire of then converting, 80-100
oc decocts 30 minutes;
IV. treat that the fluid that Step II I obtains is cooled to 30
owhen C, put into zinc oxide and the Anisodamine pulverized, Borneolum Syntheticum, Myrrha, mix rear elimination medicinal residues, to obtain final product.
Anisodamine " weight portion " of the present invention, its measurement unit can be gram or kilogram, determine according to practical application.
The present invention's pharmaceutical properties used and pharmacological action are respectively:
Rhizoma Coptidis: property bitter cold, heat clearing and damp drying, eliminating fire and detoxication.
Radix Scutellariae: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation
Radix Arnebiae (Radix Lithospermi): property bitter cold, clearing away heat and cooling blood, detoxification and removing stasis.
Flos Carthami: warm in nature, acrid in the mouth, blood circulation promoting and blood stasis dispelling, dredging collateral, removing pathogenic heat from blood and toxic substance from the body.
Myrrha: property is bitter flat, promoting blood circulation and stopping pain, promoting tissue regeneration and ulcer healing.
Radix Et Rhizoma Rhei: property bitter cold, purging fire and cooling blood, heat-clearing and toxic substances removing, dampness blood stasis dispelling.
Radix Notoginseng: nature and flavor are micro-sweet and bitter, loose blood detumescence, blood circulation promoting and blood stasis dispelling.
Rhizoma Polygoni Cuspidati: property is bitter flat, eliminating damp-heat, move back drench invigorate blood circulation, clots absorbing removing toxic substances.
Zinc oxide: have antibacterial, the anti-inflammatory anti-itch of convergence, the effect of promotion tissue repair
Anisodamine: remove affected part arteriolospasm, expand little blood vessel, increase local blood supply, improve local microcirculation, strengthen histiocyte metabolism and repair function
Borneolum Syntheticum: property is arduous, clearing heat for detumescence, antipruritic pain relieving.
Oleum sesami: have removing toxic substances and promoting granulation effect.
The present invention compared with prior art has the following advantages: medicine of the present invention is to stick in wound surface with ointment form, and it forms a kind of oiliness isolating membrane barrier, reduces thus the water evaporates of wound surface, and can prevent that wound surface from polluting.Meanwhile, it is difficult for making wound surface incrustation, wound fluid easily with the mixing mutually of (oil preparation sand cloth), be conducive to wound surface drain, therefore greatly alleviated the misery of burned patient.Its prescription all has heat-clearing and toxic substances removing, skin ulcer, blood circulation promoting and blood stasis dispelling, convergence pain relieving are controlled in detumescence, effect of putrefaction-removing granulation-promoting, it can promote wound surface local blood circulation clinically, alleviate wound surface local swelling, therefore be conducive to the coming off of recovery, slough of wound surface blood stasis and stagnant zone, the growth of epithelial tissue, it can reach the object of healing within a short period of time, makes to greatly reduce more afterwards pathologic scar.Preparation technology is simple, with low cost, and easy to use and safety is convenient to town and country extensive use.
Detailed description of the invention
Below the present invention is described in further detail.
embodiment 1a kind of externally-applied medicinal composition 1, get 15 grams of Rhizoma Coptidis, 15 grams of Radix Scutellariaes, 20 grams of Radix Arnebiae (Radix Lithospermi)s, 15 grams, Flos Carthami, 15 grams of Radix Et Rhizoma Rhei, 50 grams of Radix Notoginseng, 15 grams of Rhizoma Polygoni Cuspidati, 40 grams of zinc oxide, 0.8 gram of Anisodamine, 150 grams of Borneolum Syntheticums, 20 grams of Myrrhas, 320 grams of Oleum sesami.
2,, after Rhizoma Coptidis, Radix Scutellariae, Radix Arnebiae (Radix Lithospermi), Flos Carthami, Radix Et Rhizoma Rhei, Radix Notoginseng clean up respectively, be ground into 100 object fine powders, stand-by.
After Myrrha sterilizing, be ground into 100 order fine powders, stand-by.
Zinc oxide, Anisodamine and Borneolum Syntheticum, be ground into 100 object fine powders, stand-by.
3, the fine powder of described Rhizoma Coptidis, Radix Scutellariae, Radix Arnebiae (Radix Lithospermi), Flos Carthami, Radix Et Rhizoma Rhei and Radix Notoginseng is joined in Oleum sesami, soak after 12 hours, then the medicine of immersion and Oleum sesami are heated to 120
oc is also incubated 20 minutes, and 80-100 then converts
othe little fire of C decocts 30 minutes.
4, above-mentioned fluid is cooled to 30
owhen C, put into the fine powder of zinc oxide, Anisodamine, Borneolum Syntheticum and Myrrha, mix rear elimination medicinal residues, subpackage, to obtain final product.
2 one kinds of externally-applied medicinal compositions of embodiment
1, get 30 grams of Rhizoma Coptidis, 30 grams of Radix Scutellariaes, 25 grams of Radix Arnebiae (Radix Lithospermi)s, 20 grams, Flos Carthami, 25 grams of Radix Et Rhizoma Rhei, 70 grams of Radix Notoginseng, 25 grams of Rhizoma Polygoni Cuspidati, 55 grams of zinc oxide, 0.8 gram of Anisodamine, 150 grams of Borneolum Syntheticums, 15 grams of Myrrhas, 350 grams of Oleum sesami.
All the other steps are identical with the step 2-4 of embodiment 1 with operation.
3 one kinds of externally-applied medicinal compositions of embodiment
1, get 50 grams of Rhizoma Coptidis, 50 grams of Radix Scutellariaes, 30 grams of Radix Arnebiae (Radix Lithospermi)s, 25 grams, Flos Carthami, 50 grams of Radix Et Rhizoma Rhei, Radix Notoginseng 100,0 gram of Rhizoma Polygoni Cuspidati, 70 grams of zinc oxide, 0.8 gram of Anisodamine, 150 grams of Borneolum Syntheticums, 20 grams of Myrrhas, 380 grams of Oleum sesami.
All the other steps are identical with the step 2-4 of embodiment 1 with operation.
4 one kinds of external Pharmaceutical compositions of embodiment
1, get 30 grams of Rhizoma Coptidis, 25 grams of Radix Scutellariaes, 30 grams of Radix Arnebiae (Radix Lithospermi)s, 15 grams, Flos Carthami, 20 grams of Radix Et Rhizoma Rhei, Radix Notoginseng 60,5 grams of Rhizoma Polygoni Cuspidati, 50 grams of zinc oxide, 0.8 gram of Anisodamine, 150 grams of Borneolum Syntheticums, 15 grams of Myrrhas, 380 grams of Oleum sesami.
All the other steps are identical with the step 2-4 of embodiment 1 with operation.
test example
Externally-applied medicinal composition prepared by the embodiment of the present invention 1, the clinical therapeutic efficacy report after the 120 routine patients of burn wound use:
In 120 routine cases, male 90 examples, female's 30 examples, the oldest 62 years old, minimum 8 months.Burn cause is: boiled water is scalded 31 examples, its foot 15 examples, trunk 11 examples, head and neck face 8 examples, hand 17 examples.Fire burn 38 examples, its trunk 8 examples, head and neck face 16 examples, hand 14 examples.Chemical burn 26 examples, head and neck face 3 examples, hand 10 examples, foot 13 examples.25 examples such as skin ulceration, pressure ulcer, its trunk 12 examples, foot 13 examples.According to the chapter 13 first segment of the 6th edition " surgery " teaching material in People's Health Publisher, burn surface area and depth standards classification in clinical manifestation and diagnosis, by burn degree be divided into gently, in, severe 3 classes.In 120 routine cases, minor burn 74 examples, moderate burn 42 examples, severe burn 4 examples.
The externally-applied medicinal composition that above-mentioned 120 routine cases are all used the embodiment of the present invention 1 to prepare is treated, and using method is after burn wound is cleaned, with the gauze external application wound surface that soaks into described externally-applied medicinal composition.Slightly change dressings 3 times, moderate is changed dressings 8 times, and the next day changes dressings.Severe is changed dressings 20 times, and first 10 times, change dressings every day 1 time, the next day of latter 10 times, change dressings.
Curative effect judging standard is: recovery from illness: wound surface heals completely, slight 6 days, moderate 16 days, severe 32 days, burn wound healing person in regulation healing time.Effective: in regulation healing time, burn wound dwindles, but healing person completely not.Invalid: the burn wound that exceeds schedule time is not any change.
By above-mentioned curative effect judging standard, 120 example treatment cases are carried out to curative effect judgement and statistics statistics, the results are shown in Table 1.
Table 1 120 examples a burn case and treat curative effect statistical table
| Burn degree | Case load | Recovery from illness | Effectively | Invalid |
| Slightly | 74 | 74 | ? | ? |
| Moderate | 42 | 34 | 6 | 2 |
| Severe | 4 | 2 | 2 | ? |
| Add up to | 120 | 110 | 8 | 2 |
Conclusion:
The cure rate of externally-applied medicinal composition treatment burn prepared by the embodiment of the present invention 1 is 90%, and its 95% confidence interval is 85-95%, and total effective rate is 98%, its 95% confidence interval 90-100%.Externally-applied medicinal composition prepared by the embodiment of the present invention 1 definite curative effect of all burning is described.
Claims (2)
1. be used for the treatment of an externally-applied medicinal composition for skin injury, its formula is:
Rhizoma Coptidis 15-50 weight portion, Radix Scutellariae 15-50 weight portion, Radix Arnebiae (Radix Lithospermi) 20-30 weight portion, Flos Carthami 15-25 weight portion, Myrrha 15-20 weight portion, Radix Et Rhizoma Rhei 15-50 weight portion, Radix Notoginseng 50-100 weight portion, Rhizoma Polygoni Cuspidati 5-50 weight portion, zinc oxide 40-70 weight portion, Anisodamine 0.8 weight portion, Borneolum Syntheticum 150 weight portions, Oleum sesami 320-380 weight portion.
2. the externally-applied medicinal composition that is used for the treatment of skin injury according to claim 1, its formula is:
Rhizoma Coptidis 15 weight portions, Radix Scutellariae 15 weight portions, Radix Arnebiae (Radix Lithospermi) 20 weight portions, Flos Carthami 15 weight portions, Myrrha 20 weight portions, Radix Et Rhizoma Rhei 15 weight portions, Radix Notoginseng 50 weight portions, Rhizoma Polygoni Cuspidati 15 weight portions, zinc oxide 40 weight portions, Anisodamine 0.8 weight portion, Borneolum Syntheticum 150 weight portions, Oleum sesami 320-380 weight portion.
3, the application of externally-applied medicinal composition according to claim 1 in the medicine of preparation treatment skin injury, described skin injury is skin burn, caused by radiotherapy and chemotherapy skin injury, decubital ulcer and skin ulceration.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210445314.3A CN102920800B (en) | 2012-11-09 | 2012-11-09 | Topical drug composite and application and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210445314.3A CN102920800B (en) | 2012-11-09 | 2012-11-09 | Topical drug composite and application and preparation method thereof |
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| CN102920800A CN102920800A (en) | 2013-02-13 |
| CN102920800B true CN102920800B (en) | 2014-06-18 |
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| CN105168625B (en) * | 2015-08-31 | 2016-04-06 | 刘海燕 | A kind of clinical care is used for the treatment of the Chinese medicine liniment of two, three phase decubital ulcers |
| CN105362437A (en) * | 2015-12-25 | 2016-03-02 | 涂发妹 | Prescription of medical ointment for treating decubitus, and preparation method for medical ointment |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2001261523A (en) * | 2000-03-22 | 2001-09-26 | Kose Corp | Skin care preparation |
| EP1495763B1 (en) * | 2002-04-15 | 2009-03-18 | Tetsuo Santo | Therapeutic cream for dermatitis |
| CN1302793C (en) * | 2005-06-14 | 2007-03-07 | 马怀斌 | Cure-all ointment for treating burns and scald |
| CN101024001A (en) * | 2007-04-13 | 2007-08-29 | 张现洪 | Burn spraying medicine preparation |
| CN101167856B (en) * | 2007-10-26 | 2010-06-02 | 郭光华 | External-applied medicinal preparation for treating burns and its preparation method |
| CN102764342B (en) * | 2012-07-17 | 2013-12-04 | 陈鼎汉 | Ointment for treating bedsore, diabetic wound and scald |
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