CN102920800A - Topical drug composite and application and preparation method thereof - Google Patents
Topical drug composite and application and preparation method thereof Download PDFInfo
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- CN102920800A CN102920800A CN2012104453143A CN201210445314A CN102920800A CN 102920800 A CN102920800 A CN 102920800A CN 2012104453143 A CN2012104453143 A CN 2012104453143A CN 201210445314 A CN201210445314 A CN 201210445314A CN 102920800 A CN102920800 A CN 102920800A
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Abstract
The invention discloses a topical drug composite, and the formula comprises: by weight, 15-20 parts of rhizoma coptidis, 15-50 parts of radix scutellariae, 20-30 parts of lithospermum, 15-25 parts of safflower carthamus, 15-20 parts of myrrh, 15-50 parts of raw rhubarb, 50-100 parts of pseudo-ginseng, 15-50 parts of polygonum cuspidatum, 40-70 parts of zinc oxide, 0.8 part of anisodamine, 150 parts of borneol and 320-380 parts of sesame oil. The invention further discloses application of the topical drug composite in the preparation of drugs treating skin injury which comprises skin burn, skin scald, skin ambustion, skin lesions caused by radiation and chemotherapy, bedsore, and skin fester caused by other reasons.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of new externally-applied medicinal composition and application and preparation method.
Background technology
Patient is agonizing behind the burn, from the pathology burn skin barrier function is damaged, and the slough due to the burn is the good culture medium of antibacterial, and burn wound also is one of important sources that causes systemic infection.Burn wound's medicine for external use can be protected wound surface, protects from infection, wound healing.People constantly seek new external use burn treating medicine for many years, to reach the therapeutic purposes of expection, fast and effeciently remove patient's misery.At present, external use burn treating medicine commonly used is of a great variety both at home and abroad, and certain curative effect is arranged, but also has certain deficiency, and its therapeutic effect still can not be satisfactory.
Summary of the invention
The externally-applied medicinal composition that the purpose of this invention is to provide a kind of short treating period, instant effect, high safety, the wound repair effect is good, the rear cicatrix of healing is few, has no side effect.Externally-applied medicinal composition of the present invention is applicable to various burnings, scald, burn, put (change) treats skin injury caused and skin ulceration, pressure ulcer etc.
The present invention solves the problems of the technologies described above the technical scheme of taking:
A kind of externally-applied medicinal composition, prescription comprises:
Rhizoma Coptidis 15-50 weight portion, Radix Scutellariae 15-50 weight portion, Radix Arnebiae (Radix Lithospermi) 20-30 weight portion, Flos Carthami 15-25 weight portion, Myrrha 15-20 weight portion, Radix Et Rhizoma Rhei 15-50 weight portion, Radix Notoginseng 50-100 weight portion, Rhizoma Polygoni Cuspidati 15-50 weight portion, zinc oxide 40-70 weight portion, Anisodamine 0.8 weight portion, Borneolum Syntheticum 150 weight portions, Oleum sesami 320-380 weight portion.
Preferred prescription is:
Rhizoma Coptidis 15 weight portions, Radix Scutellariae 15 weight portions, Radix Arnebiae (Radix Lithospermi) 20 weight portions, Flos Carthami 15 weight portions, Myrrha 20 weight portions, Radix Et Rhizoma Rhei 15 weight portions, Radix Notoginseng 50 weight portions, Rhizoma Polygoni Cuspidati 15 weight portions, zinc oxide 40 weight portions, Anisodamine 0.8 weight portion, Borneolum Syntheticum 150 weight portions, Oleum sesami 320-380 weight portion.
Another object of the present invention provides the application of described externally-applied medicinal composition in the medicine of preparation treatment skin injury, and described skin injury comprises the skin ulceration that skin burn, skin scald, skin burn, caused by radiotherapy and chemotherapy skin injury, decubital ulcer, other reasons cause.
A further object of the invention is to provide the preparation method of described externally-applied medicinal composition, and its preparation process is:
I. according to prescription, get various raw materials;
II. after Rhizoma Coptidis, Radix Scutellariae, Radix Arnebiae (Radix Lithospermi), Flos Carthami, Radix Et Rhizoma Rhei, Radix Notoginseng clean up respectively, be ground into 80-100 purpose fine powder, stand-by; Be ground into 80-100 order fine powder after the Myrrha sterilization, stand-by; Zinc oxide, Anisodamine and Borneolum Syntheticum are ground into 80-100 purpose fine powder, and be stand-by;
III. the fine powder of described Rhizoma Coptidis, Radix Scutellariae, Radix Arnebiae (Radix Lithospermi), Flos Carthami, Radix Et Rhizoma Rhei and Radix Notoginseng is joined in the Oleum sesami oil and soaked 12 hours, again medicine and the Oleum sesami that soaks is heated to 120
oC also is incubated 20 minutes, the little fire of then migrating, 80-100
oC decocts 30 minutes;
IV. treat that the fluid that Step II I obtains is cooled to 30
oPut into zinc oxide and the Anisodamine pulverized during C, elimination medicinal residues behind Borneolum Syntheticum, Myrrha, the mixing, and get final product.
Anisodamine " weight portion " of the present invention, its measurement unit can be gram or kilogram, determine according to practical application.
The used pharmaceutical properties of the present invention and pharmacological action are respectively:
Rhizoma Coptidis: property bitter cold, heat clearing and damp drying, eliminating fire and detoxication.
Radix Scutellariae: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation
Radix Arnebiae (Radix Lithospermi): property bitter cold, clearing away heat and cooling blood, detoxification and removing stasis.
Flos Carthami: warm in nature, acrid in the mouth, blood circulation promoting and blood stasis dispelling, collateral dredging, removing pathogenic heat from blood and toxic substance from the body.
Myrrha: property is bitter flat, promoting blood circulation and stopping pain, promoting tissue regeneration and ulcer healing.
Radix Et Rhizoma Rhei: property bitter cold, purging fire and cooling blood, heat-clearing and toxic substances removing, dampness blood stasis dispelling.
Radix Notoginseng: nature and flavor are little sweet and bitter, loose blood detumescence, blood circulation promoting and blood stasis dispelling.
Rhizoma Polygoni Cuspidati: property is bitter flat, eliminating damp-heat, move back drench invigorate blood circulation, the clots absorbing detoxifcation.
Zinc oxide: antibiotic, the anti-inflammatory anti-itch of convergence, the effect of promotion tissue repair are arranged
Anisodamine: remove the affected part arteriolospasm, expand little blood vessel, increase the local blood supply, improve local microcirculation, strengthen histiocyte metabolism and repair function
Borneolum Syntheticum: property is arduous, clearing heat for detumescence, antipruritic pain relieving.
Oleum sesami: the removing toxic substances and promoting granulation effect is arranged.
The present invention compared with prior art has the following advantages: medicine of the present invention is to stick in wound surface with the ointment form, and it forms a kind of oiliness isolating membrane barrier, reduces thus the water evaporates of wound surface, and can prevent that wound surface from polluting.Simultaneously, it is difficult for making wound surface incrustation, wound fluid easily with the mixing mutually of (oil preparation sand cloth), be conducive to the wound surface drain, so greatly alleviated the misery of burned patient.Its prescription all has heat-clearing and toxic substances removing, skin ulcer, blood circulation promoting and blood stasis dispelling, convergence pain relieving are controlled in detumescence, the effect of putrefaction-removing granulation-promoting, it can promote the wound surface local blood circulation clinically, alleviate the wound surface local swelling, so be conducive to the coming off of recovery, slough of wound surface blood stasis and stagnant zone, the growth of epithelial tissue, it can reach the purpose of healing within a short period of time, greatly reduces pathologic scar after making more.Preparation technology is simple, with low cost, and easy to use and safety is convenient to the town and country extensive use.
The specific embodiment
Below the present invention is described in further detail.
Embodiment 1A kind of externally-applied medicinal composition 1, get Rhizoma Coptidis 15 gram, Radix Scutellariae 15 grams, Radix Arnebiae (Radix Lithospermi) 20 grams, Flos Carthami 15 grams, Radix Et Rhizoma Rhei 15 grams, Radix Notoginseng 50 grams, Rhizoma Polygoni Cuspidati 15 grams, zinc oxide 40 grams, Anisodamine 0.8 gram, Borneolum Syntheticum 150 grams, Myrrha 20 grams, Oleum sesami 320 grams.
2, after Rhizoma Coptidis, Radix Scutellariae, Radix Arnebiae (Radix Lithospermi), Flos Carthami, Radix Et Rhizoma Rhei, Radix Notoginseng clean up respectively, be ground into 100 purpose fine powders, stand-by.
Be ground into 100 order fine powders after the Myrrha sterilization, stand-by.
Zinc oxide, Anisodamine and Borneolum Syntheticum are ground into 100 purpose fine powders, and be stand-by.
3, the fine powder with described Rhizoma Coptidis, Radix Scutellariae, Radix Arnebiae (Radix Lithospermi), Flos Carthami, Radix Et Rhizoma Rhei and Radix Notoginseng joins in the Oleum sesami, soaks after 12 hours, again medicine and the Oleum sesami that soaks is heated to 120
oC also is incubated 20 minutes, and 80-100 then migrates
oThe little fire of C decocts 30 minutes.
4, above-mentioned fluid is cooled to 30
oPut into the fine powder of zinc oxide, Anisodamine, Borneolum Syntheticum and Myrrha during C, elimination medicinal residues behind the mixing, packing, and get final product.
2 one kinds of externally-applied medicinal compositions of embodiment
1, gets Rhizoma Coptidis 30 grams, Radix Scutellariae 30 grams, Radix Arnebiae (Radix Lithospermi) 25 grams, Flos Carthami 20 grams, Radix Et Rhizoma Rhei 25 grams, Radix Notoginseng 70 grams, Rhizoma Polygoni Cuspidati 25 grams, zinc oxide 55 grams, Anisodamine 0.8 gram, Borneolum Syntheticum 150 grams, Myrrha 15 grams, Oleum sesami 350 grams.
All the other steps are identical with the step 2-4 of embodiment 1 with operation.
3 one kinds of externally-applied medicinal compositions of embodiment
1, gets Rhizoma Coptidis 50 grams, Radix Scutellariae 50 grams, Radix Arnebiae (Radix Lithospermi) 30 grams, Flos Carthami 25 grams, Radix Et Rhizoma Rhei 50 grams, Radix Notoginseng 100, Rhizoma Polygoni Cuspidati 0 gram, zinc oxide 70 grams, Anisodamine 0.8 gram, Borneolum Syntheticum 150 grams, Myrrha 20 grams, Oleum sesami 380 grams.
All the other steps are identical with the step 2-4 of embodiment 1 with operation.
4 one kinds of external Pharmaceutical compositions of embodiment
1, gets Rhizoma Coptidis 30 grams, Radix Scutellariae 25 grams, Radix Arnebiae (Radix Lithospermi) 30 grams, Flos Carthami 15 grams, Radix Et Rhizoma Rhei 20 grams, Radix Notoginseng 60, Rhizoma Polygoni Cuspidati 5 grams, zinc oxide 50 grams, Anisodamine 0.8 gram, Borneolum Syntheticum 150 grams, Myrrha 15 grams, Oleum sesami 380 grams.
All the other steps are identical with the step 2-4 of embodiment 1 with operation.
Test example
The externally-applied medicinal composition of the embodiment of the invention 1 preparation, the clinical therapeutic efficacy report after the 120 routine patients of burn wound use:
In the 120 routine cases, male 90 examples, women 30 examples, the oldest 62 years old, minimum 8 months.Burn cause is: boiled water is scalded 31 examples, its foot 15 examples, trunk 11 examples, facial 8 examples of head and neck, hand 17 examples.Fire burn 38 examples, its trunk 8 examples, facial 16 examples of head and neck, hand 14 examples.Chemical burn 26 examples, facial 3 examples of head and neck, hand 10 examples, foot 13 examples.25 examples such as skin ulceration, pressure ulcer, its trunk 12 examples, foot 13 examples.According to the chapter 13 first segment of the 6th edition " surgery " teaching material in People's Health Publisher, burn surface area and depth standards classification in clinical manifestation and the diagnosis, with the burn degree be divided into gently, in, severe 3 classes.In the 120 routine cases, minor burn 74 examples, moderate burn 42 examples, severe burn 4 examples.
Above-mentioned 120 routine cases all use the externally-applied medicinal composition of the embodiment of the invention 1 preparation to treat, and using method is with after burn wound's cleaning, with the gauze external application wound surface that soaks into described externally-applied medicinal composition.Slightly change dressings 3 times, moderate is changed dressings 8 times, and the next day changes dressings.Severe is changed dressings 20 times, and front 10 times, change dressings every day 1 time, change dressings the next day of rear 10 times.
Curative effect judging standard is: recovery from illness: wound surface heals fully, and slight 6 days, moderate 16 days, severe 32 days, burn wound healing person in the regulation healing time.Effectively: burn wound dwindles in the regulation healing time, but complete healing person not.Invalid: the burn wound that exceeds schedule time is not any change.
By above-mentioned curative effect judging standard 120 example treatment cases are carried out curative effect judgement and statistics statistics, the results are shown in Table 1.
Table 1 120 examples a burn case and treat the curative effect statistical table
| The burn degree | Case load | Recovery from illness | Effectively | Invalid |
| Slightly | 74 | 74 | ? | ? |
| Moderate | 42 | 34 | 6 | 2 |
| Severe | 4 | 2 | 2 | ? |
| Add up to | 120 | 110 | 8 | 2 |
Conclusion:
The cure rate of the externally-applied medicinal composition treatment burn of the embodiment of the invention 1 preparation is 90%, and its 95% confidence interval is 85-95%, and total effective rate is 98%, its 95% confidence interval 90-100%.The externally-applied medicinal composition that the embodiment of the invention 1 preparation the is described definite curative effect of all burning.
Claims (4)
1. externally-applied medicinal composition, its prescription is:
Rhizoma Coptidis 15-50 weight portion, Radix Scutellariae 15-50 weight portion, Radix Arnebiae (Radix Lithospermi) 20-30 weight portion, Flos Carthami 15-25 weight portion, Myrrha 15-20 weight portion, Radix Et Rhizoma Rhei 15-50 weight portion, Radix Notoginseng 50-100 weight portion, Rhizoma Polygoni Cuspidati 5-50 weight portion, zinc oxide 40-70 weight portion, Anisodamine 0.8 weight portion, Borneolum Syntheticum 150 weight portions, Oleum sesami 320-380 weight portion.
2. externally-applied medicinal composition according to claim 1, its prescription is:
Rhizoma Coptidis 15 weight portions, Radix Scutellariae 15 weight portions, Radix Arnebiae (Radix Lithospermi) 20 weight portions, Flos Carthami 15 weight portions, Myrrha 20 weight portions, Radix Et Rhizoma Rhei 15 weight portions, Radix Notoginseng 50 weight portions, Rhizoma Polygoni Cuspidati 15 weight portions, zinc oxide 40 weight portions, Anisodamine 0.8 weight portion, Borneolum Syntheticum 150 weight portions, Oleum sesami 320-380 weight portion.
3. the application of pharmaceutical composition according to claim 1 in the medicine of preparation treatment skin injury, described skin injury comprises the skin ulceration that skin burn, skin scald, skin burn, caused by radiotherapy and chemotherapy skin injury, decubital ulcer, other reasons cause.
4. the preparation method of externally-applied medicinal composition according to claim 1 and 2, its preparation process is:
I. according to prescription, get various raw materials;
II. after Rhizoma Coptidis, Radix Scutellariae, Radix Arnebiae (Radix Lithospermi), Flos Carthami, Radix Et Rhizoma Rhei, Radix Notoginseng clean up respectively, be ground into 80-100 purpose fine powder, stand-by; Be ground into 80-100 order fine powder after the Myrrha sterilization, stand-by; Zinc oxide, Anisodamine and Borneolum Syntheticum are ground into 80-100 purpose fine powder, and be stand-by;
III. the fine powder of described Rhizoma Coptidis, Radix Scutellariae, Radix Arnebiae (Radix Lithospermi), Flos Carthami, Radix Et Rhizoma Rhei and Radix Notoginseng is joined in the Oleum sesami oil and soaked 12 hours, again medicine and the Oleum sesami that soaks is heated to 120
oC also is incubated 20 minutes, the little fire of then migrating, 80-100
oC decocts 30 minutes;
IV. treat that the fluid that Step II I obtains is cooled to 30
oPut into zinc oxide and the Anisodamine pulverized during C, elimination medicinal residues behind Borneolum Syntheticum, Myrrha, the mixing, and get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210445314.3A CN102920800B (en) | 2012-11-09 | 2012-11-09 | Topical drug composite and application and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210445314.3A CN102920800B (en) | 2012-11-09 | 2012-11-09 | Topical drug composite and application and preparation method thereof |
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| CN102920800A true CN102920800A (en) | 2013-02-13 |
| CN102920800B CN102920800B (en) | 2014-06-18 |
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| CN201210445314.3A Expired - Fee Related CN102920800B (en) | 2012-11-09 | 2012-11-09 | Topical drug composite and application and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168625A (en) * | 2015-08-31 | 2015-12-23 | 陈红 | Traditional Chinese medicine liniment for treating stage 2 and stage 3 bedsores in clinical nursing |
| CN105362437A (en) * | 2015-12-25 | 2016-03-02 | 涂发妹 | Prescription of medical ointment for treating decubitus, and preparation method for medical ointment |
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| JP2001261523A (en) * | 2000-03-22 | 2001-09-26 | Kose Corp | Skin care preparation |
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| CN1723931A (en) * | 2005-06-14 | 2006-01-25 | 马怀斌 | Cure-all ointment for treating burns and scald |
| CN101024001A (en) * | 2007-04-13 | 2007-08-29 | 张现洪 | Burn spraying medicine preparation |
| CN101167856A (en) * | 2007-10-26 | 2008-04-30 | 郭光华 | External-applied medicinal preparation for treating burns and its preparation method |
| CN102764342A (en) * | 2012-07-17 | 2012-11-07 | 陈鼎汉 | Ointment for treating bedsore, diabetic wound and scald |
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2012
- 2012-11-09 CN CN201210445314.3A patent/CN102920800B/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001261523A (en) * | 2000-03-22 | 2001-09-26 | Kose Corp | Skin care preparation |
| CA2480221A1 (en) * | 2002-04-15 | 2003-10-23 | Tetsuo Santo | Cream for therapy of dermatitis |
| CN1723931A (en) * | 2005-06-14 | 2006-01-25 | 马怀斌 | Cure-all ointment for treating burns and scald |
| CN101024001A (en) * | 2007-04-13 | 2007-08-29 | 张现洪 | Burn spraying medicine preparation |
| CN101167856A (en) * | 2007-10-26 | 2008-04-30 | 郭光华 | External-applied medicinal preparation for treating burns and its preparation method |
| CN102764342A (en) * | 2012-07-17 | 2012-11-07 | 陈鼎汉 | Ointment for treating bedsore, diabetic wound and scald |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168625A (en) * | 2015-08-31 | 2015-12-23 | 陈红 | Traditional Chinese medicine liniment for treating stage 2 and stage 3 bedsores in clinical nursing |
| CN105362437A (en) * | 2015-12-25 | 2016-03-02 | 涂发妹 | Prescription of medical ointment for treating decubitus, and preparation method for medical ointment |
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| CN102920800B (en) | 2014-06-18 |
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