CN108272960B - Traditional Chinese medicine composition for treating hemorrhoidal disease and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating hemorrhoidal disease and preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition for treating hemorrhoidal disease, and a preparation method and application thereof, wherein the Chinese medicinal composition comprises the following raw material medicaments in part by weight: 10-20 parts of rheum officinale, 10-20 parts of coptis chinensis, 12-20 parts of scutellaria baicalensis, 23-35 parts of frankincense, 20-38 parts of myrrh, 6-14 parts of angelica sinensis, 6-14 parts of salvia miltiorrhiza, 23-40 parts of mirabilite, 10-20 parts of gallnut, 10-20 parts of bletilla, 6-14 parts of alum and 3-7 parts of borneol. The traditional Chinese medicine composition has the advantages of obvious curative effect on patients with hemorrhoidal disease, small toxic and side effect, simple preparation process, convenient use, unique advantage of quick response by external application and better clinical application prospect.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating hemorrhoidal disease, and a preparation method and application thereof.
Background
Hemorrhoidal disease is a common disease affecting human health, has extremely high morbidity, obvious symptoms and great pain, and has the main symptoms of hemafecia, pain, prolapse, local secretion increase, difficult defecation and the like. The pathogenesis is caused by the imbalance of yin and yang of human body, and the factors of exogenous wind, heat, dryness and dampness, internal injury of six excesses and seven emotions and the like.
The common methods for treating hemorrhoidal diseases are to take medicinal decoction, suppository, ointment or operation, and because the surgical excision has great pain and the current medicinal preparation for treating hemorrhoidal diseases cannot meet the clinical requirement, an external preparation for effectively treating hemorrhoidal diseases is urgently needed to treat the hemorrhoidal diseases and improve the life quality of patients.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for treating hemorrhoidal disease and a preparation method and application thereof.
The invention provides a traditional Chinese medicine composition which is prepared from the following raw materials in parts by weight:
10-20 parts of rheum officinale, 10-20 parts of coptis chinensis, 12-20 parts of scutellaria baicalensis, 23-35 parts of frankincense, 20-38 parts of myrrh, 6-14 parts of angelica sinensis, 6-14 parts of salvia miltiorrhiza, 23-40 parts of mirabilite, 10-20 parts of gallnut, 10-20 parts of bletilla, 6-14 parts of alum and 3-7 parts of borneol.
Preferably, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight:
12-17 parts of rheum officinale, 12-18 parts of coptis chinensis, 14-18 parts of scutellaria baicalensis, 25-33 parts of frankincense, 25-35 parts of myrrh, 8-12 parts of angelica sinensis, 8-12 parts of salvia miltiorrhiza, 25-35 parts of mirabilite, 12-18 parts of gallnut, 12-18 parts of bletilla, 8-12 parts of alum and 4-6 parts of borneol.
Further preferably, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight:
15 parts of rhubarb, 15 parts of coptis chinensis, 15 parts of scutellaria baicalensis, 30 parts of frankincense, 30 parts of myrrh, 10 parts of angelica, 10 parts of salvia miltiorrhiza, 30 parts of mirabilite, 15 parts of gallnut, 15 parts of rhizoma bletillae, 10 parts of alum and 5 parts of borneol.
The traditional Chinese medicine composition is prepared by taking raw medicinal materials, aqueous extracts or organic solvent extracts of rhubarb, coptis chinensis, scutellaria baicalensis, frankincense, myrrh, angelica sinensis, salvia miltiorrhiza, mirabilite, gallnut, rhizoma bletillae, alum and borneol as active ingredients and adding pharmaceutically acceptable auxiliary materials.
Further, the preparation is an external preparation.
Further, the external preparation is lotion, plastics, liniment, cataplasm, decoction, powder, ointment, aerosol or spray.
Preferably, the external preparation is a lotion.
The invention provides a method for preparing the traditional Chinese medicine composition, which comprises the following steps:
(1) weighing the raw material medicines in the weight ratio;
(2) drying, pulverizing, and sieving.
Wherein in the step (2), the sieving is 120-mesh sieving.
The application of the traditional Chinese medicine composition in preparing a medicine for treating hemorrhoidal disease.
Preferably, the hemorrhoidal disease is internal hemorrhoid, external hemorrhoid or mixed hemorrhoid.
The traditional Chinese medicine composition is prepared from twelve medicines of rhubarb, coptis chinensis, scutellaria baicalensis, frankincense, myrrh, angelica sinensis, salvia miltiorrhiza, mirabilite, gallnut, rhizoma bletillae, alum and borneol.
The recipe is prepared from modified Xiexin decoction and Huoluo effective Lingdan. The Suwen, Zhizhen important theory records that the sores and pains all belong to the heart, and the rhubarb, the coptis and the scutellaria in the prescription have the functions of clearing away heat and toxic materials, purging the heart and curing sores, and relieving swelling and pain; frankincense, myrrh, angelica and salvia miltiorrhiza which are named as 'Huoluo Xiaolingdan' for activating blood circulation and removing blood stasis, and dredging collaterals and relieving pain; natrii sulfas softens hardness and dissipates nodulation, and Galla chinensis stops bleeding, astringes and relieves depletion; rhizoma Bletillae has astringent, hemostatic, repercussive, and granulation promoting effects; alum eliminates dampness and stops bleeding; relieve swelling and pain, clear heat and remove toxicity. The medicines are combined to play the effects of clearing heat and promoting diuresis, healing sores and stopping bleeding, and relieving swelling and pain.
The traditional Chinese medicine composition has the advantages of obvious curative effect on patients with hemorrhoidal disease, small toxic and side effect, simple preparation process, convenient use, unique advantage of quick response by external application and better clinical application prospect.
According to the above-mentioned aspects of the present invention, many other modifications, substitutions, or alterations can be made without departing from the basic technical concept of the present invention as defined by the general technical knowledge and common practice in the field relevant to the present invention.
The present invention will be described in further detail with reference to the following examples. This should not be understood as limiting the scope of the above-described subject matter of the present invention to the following examples. All the technologies realized based on the above contents of the present invention belong to the scope of the present invention.
Detailed Description
EXAMPLE 1 preparation of the Chinese medicinal composition of the present invention
1. Raw materials: 15g of rheum officinale, 15g of coptis chinensis, 15g of scutellaria baicalensis, 30g of frankincense, 30g of myrrh, 10g of angelica sinensis, 10g of salvia miltiorrhiza, 30g of mirabilite, 15g of gallnut, 15g of rhizoma bletillae, 10g of alum and 5g of borneol.
2. The preparation method comprises the following steps: weighing the raw material medicines according to the weight ratio; pulverizing into fine powder, and sieving with 120 mesh sieve.
EXAMPLE 2 preparation of the Chinese medicinal composition of the present invention
1. Raw materials: 17g of rhubarb, 18g of coptis chinensis, 20g of scutellaria baicalensis, 35g of frankincense, 35g of myrrh, 14g of angelica, 12g of salvia miltiorrhiza, 35g of mirabilite, 18g of gallnut, 18g of rhizoma bletillae, 12g of alum and 7g of borneol.
2. The preparation method comprises the following steps: weighing the raw material medicines according to the weight ratio; the same as in example 1.
EXAMPLE 3 preparation of the Chinese medicinal composition of the present invention
1. Raw materials: 12g of rhubarb, 12g of coptis chinensis, 12g of scutellaria baicalensis, 23g of frankincense, 25g of myrrh, 6g of angelica, 8g of salvia miltiorrhiza, 23g of mirabilite, 12g of gallnut, 10g of rhizoma bletillae, 8g of alum and 3g of borneol.
2. The preparation method comprises the following steps: weighing the raw material medicines according to the weight ratio; the same as in example 1.
EXAMPLE 4 preparation of the Chinese medicinal composition of the present invention
1. Raw materials: 20g of rheum officinale, 20g of coptis chinensis, 18g of scutellaria baicalensis, 33g of frankincense, 38g of myrrh, 12g of angelica sinensis, 14g of salvia miltiorrhiza, 40g of mirabilite, 20g of gallnut, 20g of rhizoma bletillae, 14g of alum and 6g of borneol.
2. The preparation method comprises the following steps: weighing the raw material medicines according to the weight ratio; the same as in example 1.
EXAMPLE 5 preparation of the Chinese medicinal composition of the present invention
1. Raw materials: 10g of rheum officinale, 10g of coptis chinensis, 14g of scutellaria baicalensis, 25g of frankincense, 20g of myrrh, 8g of angelica sinensis, 6g of salvia miltiorrhiza, 25g of mirabilite, 10g of gallnut, 12g of rhizoma bletillae, 6g of alum and 4g of borneol.
2. The preparation method comprises the following steps: weighing the raw material medicines according to the weight ratio; the same as in example 1.
The beneficial effects of the present invention are demonstrated by specific clinical trials below.
Test example 1 clinical efficacy of the composition of the present invention
1. Clinical data
The experimental group selects 50 patients with mixed hemorrhoids from outpatient clinic of the hospital in 2017 and 1-12 months, and all the patients are confirmed to be the mixed hemorrhoids after examination. 26 men and 24 women; the age is 25-65 years, and the average age is 38.25 +/-10.15 years.
1.1 diagnostic criteria:
the anal diseases are diagnosed according to the hemorrhoid diagnosis standard formulated by the anal and intestinal subcontract of the Chinese medical society in 2006, the rectal and anal surgical science group of the Chinese medical society, and the large intestine and anal diseases professional committee of the Chinese medical society of Chinese traditional and western medicine.
1. Internal hemorrhoid
The main clinical manifestations are bleeding and prolapse, complicated with thrombus, incarceration, strangulation and difficult defecation. The severity of the symptoms of internal hemorrhoids is 4 degrees.
I degree: bloody when defecating, blood dripping, bleeding can stop automatically after defecating; no hemorrhoid prolapse.
II degree: hematochezia is frequent; during defecation, hemorrhoids may be prolapsed and the patient can be returned to the stool.
And (3) III degree: optionally hematochezia; defecation or long standing, cough, fatigue and hemorrhoid coming out when bearing load, and need to be taken back by hand.
IV degree: optionally hematochezia; the hemorrhoids are prone to prolapse continuously or after reduction.
2. External hemorrhoid
The main clinical manifestations are anus soft tissue mass, discomfort, pruritus or foreign body sensation, such as thrombosis and inflammation.
3. Mixed hemorrhoid
The main clinical manifestations are that the symptoms of internal hemorrhoid and external hemorrhoid exist simultaneously, and the serious manifestations are that the annular hemorrhoid is prolapsed.
1.2 inclusion criteria
Cases meeting the diagnosis criteria of section 1.1 were included.
2. Method of treatment
Experimental groups: the drug of example 1 of the present invention was administered.
The specific administration method comprises the following steps:
adding 800ml of boiled water into the medicine powder in the embodiment 1, wherein the volume mass ratio of the boiled water to the medicine powder is 800: 100mL/g, soaking for 10 minutes, then hip bathing for 15 minutes at proper temperature for 2 times in 1 day. The weight of the medicine soaked in each time is equivalent to 100g of crude drugs.
3. Observation of therapeutic effects
3.1 therapeutic effect standard:
(1) and (3) healing: symptoms (hematochezia, prolapse, or pain) disappeared, and the hemorrhoids were checked to have disappeared.
(2) Improvement: the symptoms are obviously improved after the treatment, and the hemorrhoids are obviously reduced after the examination.
(3) And (4) invalidation: the symptoms and the forms are unchanged from before treatment.
3.2 therapeutic results
As shown in table 1:
| group of | Recovery method | Improvement of life | Invalidation | Rate of recovery | High efficiency |
| Experimental group (50 persons) | 20 | 30 | 0 | 40％ | 100％ |
And (4) experimental conclusion: the 50 patients treated by the traditional Chinese medicine composition disclosed by the invention are cured for 20 patients and improved for 30 patients, the cure rate reaches 40%, the effective rate reaches 100%, and the results show that the traditional Chinese medicine composition disclosed by the invention is reasonable in formula, remarkable in curative effect on hemorrhoids and worthy of clinical popularization and application.
4. Typical cases
4.1 classical case 1
When a certain male is in age of 48 years, the anal lump appears for 3 years repeatedly, and the disease is aggravated with hematochezia for 1 week.
The symptoms are as follows: prolapse of anal swelling, anal pendulous pain, no pruritus, no tenesmus, no intolerance of cold, no fever, no abdominal pain and diarrhea, poor sleep, poor appetite, normal urine, and unsmooth defecation for 1-2 times per day. The mixed hemorrhoid with thrombus type external hemorrhoid is confirmed and diagnosed by the special examination.
The treatment method comprises the following steps: the medicine and the preparation method of the invention in the embodiment 1 are taken, 100g of fine powder is added with 800ml of boiled water, the mixture is soaked for 10 minutes and then is subjected to hip bath at proper temperature for 15 minutes, and the medicine and the preparation method are respectively taken once in the morning and at night every day for continuous treatment for 2 weeks. The curative effect is as follows: after the patient is treated for 2 weeks, the hematochezia, prolapse and pain disappear, and the clinical cure is realized.
In conclusion, the traditional Chinese medicine composition has the advantages of obvious curative effect on patients with hemorrhoidal diseases, small toxic and side effects, simple preparation process, convenient use, unique advantage of quick response by external application and better clinical application prospect.
Claims (7)
1. A traditional Chinese medicine composition for treating hemorrhoidal disease is characterized in that: the traditional Chinese medicine is prepared from the following raw materials in parts by weight: 15 parts of rhubarb, 15 parts of coptis chinensis, 15 parts of scutellaria baicalensis, 30 parts of frankincense, 30 parts of myrrh, 10 parts of angelica, 10 parts of salvia miltiorrhiza, 30 parts of mirabilite, 15 parts of gallnut, 15 parts of rhizoma bletillae, 10 parts of alum and 5 parts of borneol.
2. The traditional Chinese medicine composition according to claim 1, characterized in that: the preparation is prepared by taking raw medicinal materials, aqueous extracts or organic solvent extracts of rhubarb, coptis, scutellaria, frankincense, myrrh, angelica, salvia, mirabilite, gallnut, rhizoma bletillae, alum and borneol as active ingredients and adding pharmaceutically acceptable auxiliary materials.
3. The traditional Chinese medicine composition according to claim 2, characterized in that: the preparation is an external preparation.
4. The traditional Chinese medicine composition according to claim 3, wherein: the external preparation is lotion, plastics, liniment, cataplasm, decoction, powder, ointment, aerosol or spray.
5. The traditional Chinese medicine composition according to claim 4, wherein: the external preparation is lotion.
6. A method of preparing the Chinese medicinal composition of any one of claims 1 to 5, wherein: it comprises the following steps:
(1) weighing the raw material medicines in the weight ratio;
(2) drying, pulverizing, and sieving;
in the step (2), the sieving is performed by a 120-mesh sieve.
7. Use of the Chinese medicinal composition of any one of claims 1 to 5 in the preparation of a medicament for treating mixed hemorrhoids.
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|---|---|---|---|---|
| KR20060033070A (en) * | 2004-10-14 | 2006-04-19 | 김태균 | Hip-bath compositions for treatment of herorrhoids or gynecological diseases, and hip-bath bag containing it |
| CN102370815A (en) * | 2010-08-11 | 2012-03-14 | 郁锋 | Hemorrhoid external treatment powder |
| CN105233180A (en) * | 2015-11-16 | 2016-01-13 | 庄小侃 | Drug for treating internal hemorrhoid due to damp-heat pouring downward syndrome |
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2018
- 2018-03-29 CN CN201810272996.XA patent/CN108272960B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060033070A (en) * | 2004-10-14 | 2006-04-19 | 김태균 | Hip-bath compositions for treatment of herorrhoids or gynecological diseases, and hip-bath bag containing it |
| CN102370815A (en) * | 2010-08-11 | 2012-03-14 | 郁锋 | Hemorrhoid external treatment powder |
| CN105233180A (en) * | 2015-11-16 | 2016-01-13 | 庄小侃 | Drug for treating internal hemorrhoid due to damp-heat pouring downward syndrome |
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| Title |
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| 加味四黄膏治疗肛门急性炎症253例;董耀林;《中国农村医学》;19921231(第8期);第8页 * |
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