CN109847015B - Traditional Chinese medicine lotion and preparation method and application thereof - Google Patents
Traditional Chinese medicine lotion and preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine lotion and a preparation method and application thereof, wherein the traditional Chinese medicine lotion is prepared by leaching the following raw materials in parts by weight with water: 15-20 parts of radix sophorae flavescentis, 15-20 parts of fructus cnidii, 15-20 parts of rhizoma smilacis glabrae, 10-15 parts of rose, 30-35 parts of buffalo horn, 6-10 parts of liquorice, 15-20 parts of cassia twig and 15-20 parts of talcum. The traditional Chinese medicine lotion fully exerts the characteristics and advantages of the traditional Chinese medicine external treatment method, directly acts on the anus part, has quick effect and small toxic and side effects, and utilizes the characteristics of minerals and plants to be ingeniously and organically combined to ensure that the proportion of the lotion is in a balanced state. The traditional Chinese medicine lotion is used for daily perianal nursing of bone marrow transplant patients, can effectively prevent infection and perianal abscess diseases, has excellent effects of cleaning anus and protecting anus diseases, and has the advantages of safety, no toxicity and the like.
Description
(I) technical field
The invention relates to the technical field of functional health products and medicines, in particular to a traditional Chinese medicine lotion and a preparation method and application thereof.
(II) background of the invention
For immunocompromised patients, prevention and treatment of infection throughout the course of treatment is an important factor in success or failure of treatment. There are many opportunities for causing infection, both with exogenous infection and infection due to foci of infection formed by potential pathogens in the body. The anus is an outlet for excreting dirt in the digestive tract of the organism, and as the anus sphincter forms a folded anatomical structure, favorable conditions are created for hiding bacteria. When the immune function of a patient is extremely low, if the patient suffers from micro-damage or improper nursing, perianal infection or perianal abscess can be caused, so that the patient can be threatened by systemic infection. Therefore, in daily perianal care, there is a need for a lotion for anal cleansing and health.
Disclosure of the invention
The invention aims to provide a traditional Chinese medicine lotion and a preparation method and application thereof, and the traditional Chinese medicine lotion is used for cleaning perianal nursing of patients with low immunity, so that cleanness around anus is ensured, infection can be effectively prevented, perianal abscess diseases are prevented, postoperative complications are reduced, and the cure rate is improved.
The technical scheme adopted by the invention is as follows:
the invention provides a traditional Chinese medicine lotion which is prepared by leaching the following raw materials in parts by weight with water: 15-20 parts of radix sophorae flavescentis, 15-20 parts of fructus cnidii, 15-20 parts of rhizoma smilacis glabrae, 10-15 parts of rose, 30-35 parts of buffalo horn, 6-10 parts of liquorice, 15-20 parts of cassia twig and 15-20 parts of talcum.
Further, the traditional Chinese medicine lotion is prepared by leaching the following raw materials in parts by weight with water: 15 parts of radix sophorae flavescentis, 15 parts of fructus cnidii, 15 parts of rhizoma smilacis glabrae, 10 parts of rose, 30 parts of buffalo horn, 6 parts of liquorice, 15 parts of cassia twig and 15 parts of talcum.
Further, the traditional Chinese medicine lotion is prepared by leaching the following raw materials in parts by weight with water: 20 parts of radix sophorae flavescentis, 20 parts of fructus cnidii, 20 parts of rhizoma smilacis glabrae, 15 parts of rose, 35 parts of buffalo horn, 10 parts of liquorice, 20 parts of cassia twig and 20 parts of talcum.
Further, the traditional Chinese medicine lotion is an extracting solution obtained by adding 1-10 times of water by weight to each raw material according to the formula amount and extracting.
The invention also provides a preparation method of the traditional Chinese medicine lotion, which comprises the following steps:
1) extracting effective components:
soaking radix Sophorae Flavescentis in 4-10 times of water at room temperature for 1-3 hr (preferably 4 times of water, 1 hr), decocting for 2-3 times (preferably 2 times), each time for 30-45 min (preferably 30 min), and filtering to obtain radix Sophorae Flavescentis extractive solution;
decocting fructus Cnidii in 2-8 times of water for 2-3 times (preferably 2 times of water for 2 times), each time for 30-45 min (preferably 30 min), and filtering to obtain fructus Cnidii extractive solution;
adding 2-8 times of water into rhizoma Smilacis Glabrae according to the formula amount, soaking at room temperature for 1-3 hr, decocting for 2-3 times (preferably 2 times of water, 1 hr, 2 times of decocting for 30min each time), and filtering to obtain rhizoma Smilacis Glabrae extractive solution;
adding 2-8 times of water into ramulus Cinnamomi, soaking at room temperature for 1-3 hr, decocting for 2-3 times (preferably 2 times of water, 1 hr, 2 times of decoction, 30min each time) for 30min-45min, and filtering to obtain ramulus Cinnamomi extractive solution;
2) preparation: mixing the extractive solutions of step 1), adding flos Rosae Rugosae, cornu Bubali, Glycyrrhrizae radix and pulvis Talci, decocting for 10-30 min for 1-2 times, filtering, collecting filtrate, bottling, sterilizing, capping, and packaging.
The invention also provides application of the traditional Chinese medicine lotion as a lotion for treating perianal inflammation.
The Chinese medicinal lotion of the invention has the following usage and dosage: for external use, 50-100ml of the liquid medicine is taken, diluted by warm boiled water by 20 times to the appropriate temperature, and washed by a flusher or locally soaked and bathed by a hip.
The immunity of the postoperative patients is reduced, and the infection chances are increased. The inventor develops the pharmaceutical composition of the invention aiming at the pathogenesis of the traditional Chinese medicine under the guidance of the traditional Chinese medicine theory and on the basis of clinical experience. The radix sophorae flavescentis in the formula has the effects of resisting bacteria and diminishing inflammation, the fructus cnidii has the effects of dispelling dampness and expelling wind, the rhizoma smilacis glabrae has the effects of detoxifying and eliminating dampness, the rose flower has strong fragrance, the buffalo horn has the effects of clearing heat and detoxifying, the liquorice has the effects of resisting inflammation and allergy, relieving the drug toxicity, the cassia twig has the effect of dispelling cold and relieving pain, and the talc has the effects of dispelling dampness and healing sore. The traditional Chinese medicine composition has the effects of clearing away heat and toxic materials, diminishing inflammation, sterilizing, relieving swelling and pain, promoting blood circulation, stopping bleeding, promoting tissue regeneration and healing sore, and is a good prescription beneficial to perianal nursing of postoperative patients.
The basic sources and the effects of the medicinal materials in the formula are as follows:
the radix Sophorae Flavescentis is dried root of radix Sophorae Flavescentis of Leguminosae, collected in spring and autumn, removed root head and branch root, cleaned, dried, or sliced and dried. It is bitter and cold. Has antibacterial and anti-inflammatory effects, and can inhibit acne bacillus, Staphylococcus aureus, and Escherichia coli.
Cnidium fruit (Cnidium monnieri (L.) cuss., named as wild carrot seed, is a dry mature fruit of Cnidium monnieri (bur.) of the family umbelliferae, is warm in nature, smells and cries, and has the effects of eliminating dampness, dispelling wind and killing insects.
Rhizoma Smilacis Glabrae is dried rhizome of Smilax scobinicaulis in Liliaceae, and has sweet, light and neutral taste, and has effects of removing toxic substance, eliminating dampness, and smoothing joint movement.
The flos Rosae Rugosae is dried flower bud of Rosa rugosa Thunb of Rosaceae, has aromatic fragrance, slightly bitter and astringent taste, and has effects of activating qi-flowing, resolving stagnation, regulating blood, and relieving pain.
Cornu Bubali is a substitute of cornu Rhinocerotis, has bitter and cold nature, and has effects of clearing heat, cooling blood, arresting convulsion, and removing toxic substance.
The Glycyrrhrizae radix is dried root and rhizome of Glycyrrhiza uralensis Fisch, Glycyrrhiza inflata Bat or Glycyrrhiza glabra L of Leguminosae, and has antiinflammatory, antiallergic, sore toxicity relieving, drug toxicity relieving, and strong effects.
Cassia twig, a dry twig of Cinnamomum cassia Presl of Lauraceae, is pungent, sweet and warm in taste. Has effects of inducing sweat, relieving exterior syndrome, dispelling cold, relieving pain, activating yang, and regulating qi-flowing.
Talcum is cold in nature, sweet and light in flavor, and has the effects of inducing diuresis for treating stranguria, clearing away summer-heat, and eliminating dampness and healing sore for external use.
Compared with the prior art, the invention has the following beneficial effects:
the traditional Chinese medicine lotion fully exerts the characteristics and advantages of the traditional Chinese medicine external treatment method, directly acts on the anus part, has quick effect and small toxic and side effects, and utilizes the characteristics of minerals and plants to be ingeniously and organically combined to ensure that the proportion of the lotion is in a balanced state. The traditional Chinese medicine lotion is used for daily perianal nursing of bone marrow transplant patients, can effectively prevent infection and perianal abscess diseases, has excellent effects of cleaning anus and protecting anus diseases, and has the advantages of safety, no toxicity and the like.
(IV) description of the drawings
FIG. 1 shows the bacteriostatic effect of the traditional Chinese medicine lotion.
(V) detailed description of the preferred embodiments
The invention will be further described with reference to specific examples, but the scope of the invention is not limited thereto:
the radix sophorae flavescentis, the fructus cnidii, the rhizoma smilacis glabrae, the rose, the buffalo horn, the liquorice, the cassia twig and the talc used in the embodiment of the invention are collected and prepared according to the 2015 edition of Chinese pharmacopoeia. The room temperature of the invention is 25-30 ℃.
Example 1:
1. formulation of
The perianal lotion is prepared by leaching the following raw materials in parts by weight with water: 15g of radix sophorae flavescentis, 15g of fructus cnidii, 15g of rhizoma smilacis glabrae, 10g of rose, 30g of buffalo horn, 6g of liquorice, 15g of cassia twig and 15g of talcum.
2. The preparation method of the traditional Chinese medicine lotion is characterized by comprising the following steps:
1) extracting effective components:
placing 15g radix Sophorae Flavescentis in a container, adding 4 times of water, soaking at room temperature for 1 hr, decocting for 2 times, each time for 30min, and filtering to obtain radix Sophorae Flavescentis extractive solution;
putting 15g of fructus cnidii into a container, adding 2 times of water by weight, decocting for 2 times, each time for 30 minutes, and filtering to obtain fructus cnidii extract for later use;
placing 15g of rhizoma smilacis glabrae in a container, adding 2 times of water by weight, soaking for 1 hour at room temperature, decocting for 2 times, each time for 30 minutes, and filtering to obtain rhizoma smilacis glabrae extract for later use;
placing 15g of cassia twig in a container, adding 2 times of water by weight, soaking for 1 hour at room temperature, decocting for 2 times, each time for 30 minutes, and filtering to obtain cassia twig extract for later use;
2) preparation: mixing the extractive solutions in step 1), adding 10g of flos Rosae Rugosae, 30g of cornu Bubali, 6g of Glycyrrhrizae radix and 15g of pulvis Talci, decocting for 1 time, each time for 10 min, and filtering;
3) bottling, sterilizing, capping and packaging the filtrate prepared in the step 2).
3. The application and dosage are as follows: for external use, 50-100ml of the liquid medicine is taken, diluted by warm boiled water by 20 times to the appropriate temperature, and washed by a flusher or locally soaked and bathed by a hip.
Example 2:
1. the formula is as follows:
the perianal lotion is prepared by leaching the following raw materials in parts by weight with water: 20g of radix sophorae flavescentis, 20g of fructus cnidii, 20g of rhizoma smilacis glabrae, 15g of rose, 35g of buffalo horn, 10g of liquorice, 20g of cassia twig and 20g of talcum.
2. The preparation method of the traditional Chinese medicine lotion comprises the following steps:
1) extracting effective components:
placing 20g radix Sophorae Flavescentis in a container, adding 10 times of water, soaking for 3 hr, decocting for 3 times (45 min each time), and filtering to obtain radix Sophorae Flavescentis extractive solution;
putting 20g of fructus cnidii into a container, adding 8 times of water by weight, decocting for 3 times, each time for 45 minutes, and filtering to obtain fructus cnidii extract for later use;
placing 20g of rhizoma smilacis glabrae in a container, adding 8 times of water, soaking for 3 hours at room temperature, decocting for 3 times, each time for 45 minutes, and filtering to obtain rhizoma smilacis glabrae extract for later use;
placing 20g of cassia twig in a container, adding 8 times of water by weight, soaking for 3 hours at room temperature, decocting for 3 times, each time for 45 minutes, and filtering to obtain a cassia twig extract for later use;
2) preparation: mixing the extractive solutions in step 1), adding 15g of flos Rosae Rugosae, 35g of cornu Bubali, 10g of Glycyrrhrizae radix and 20g of pulvis Talci, decocting for 2 times (30 min each time), and filtering;
3) bottling, sterilizing, capping and packaging the filtrate prepared in the step 2).
3. The application and dosage are as follows: for external use, 50-100ml of the liquid medicine is taken, diluted by warm boiled water by 20 times to the appropriate temperature, and washed by a flusher or locally soaked and bathed by a hip.
Example 3 study of bacteriostatic effects of perianal lotion
The Time-kit method is used for detecting the antibacterial effect of the invention, the strain is Escherichia coli ATCC (American Type Culture Collection) 25922, and the antibiotic is oxytetracycline (purity 92.4%) purchased from China pharmaceutical and biological product institute. The method comprises the following specific steps:
(1) escherichia coli ATCC25922 in logarithmic growth phase was diluted to 2X 10 with LB medium5CFU/mL bacterial liquid. LB culture medium: 10g/L of tryptone, 5g/L of yeast extract, 10g/L of sodium chloride and water as a solvent, and the pH value is 7.4.
(2) A sterile flat-bottom 96-well plate was used, and 10. mu.L of each of the bacterial suspension of step (1) was added to each well of the 96-well plate.
(3) 10 μ L of each of the Chinese medicinal lotions prepared in example 1 was added to the corresponding wells, and each material was subjected to three replicates. Under the same conditions, the washing solution prepared in example 1 was replaced with penicillin having a concentration of 200U/ml, and a control containing no bacterial solution and only medium was provided.
(4) Incubate at 37 ℃ for 24 hours in a humidified state, during which time the plates are scanned at 1, 4, 8, 16 and 24 hours, respectively, and record the OD of each well490And (3) drawing a curve according to the obtained data, wherein the result is shown in figure 1, and the result shows that the traditional Chinese medicine lotion has an obvious bacteriostatic effect.
Example 4 verification of the Effect of perianal lotion
60 patients were treated with the herbal lotion prepared in example 1, 37 men, 23 women, the greatest age 47, and the least age 6. The main symptoms comprise 36 cases of patients with hemorrhoids, 10 cases of perianal abscess, 5 cases of perianal eczema and 9 cases of anal pruritus. For external use, 50-100ml of the liquid medicine is taken, diluted by warm boiled water by 20 times to the appropriate temperature, and washed by a flusher or locally soaked and bathed by a hip. The treatment course is 1 month. After 1 week of use of the lotion, various symptoms were improved or alleviated to various degrees. The above 60 patients were used to find any adverse events.
Table 1 verification of the efficacy of the lotion of the present invention
| Chief complaints | The number of people before taking medicine | Number of effective people | Display efficiency | Number of good turning people | Good rate of conversion | High efficiency |
| Hemorrhoid treatment | 36 | 30 | 83.3％ | 6 | 16.7％ | 100％ |
| Perianal abscess | 10 | 4 | 40％ | 6 | 60％ | 100％ |
| Eczema of perianal region | 5 | 2 | 40％ | 2 | 40％ | 80％ |
| Pruritus ani | 9 | 4 | 44.4％ | 5 | 55.6％ | 100％ |
Claims (6)
1. The traditional Chinese medicine lotion for treating perianal inflammation is characterized by being prepared by leaching the following raw materials in parts by weight with water: 15-20 parts of radix sophorae flavescentis, 15-20 parts of fructus cnidii, 15-20 parts of rhizoma smilacis glabrae, 10-15 parts of rose, 30-35 parts of buffalo horn, 6-10 parts of liquorice, 15-20 parts of cassia twig and 15-20 parts of talcum.
2. The traditional Chinese medicine lotion according to claim 1, wherein the traditional Chinese medicine lotion is prepared by leaching the following raw materials in parts by weight with water: 15 parts of radix sophorae flavescentis, 15 parts of fructus cnidii, 15 parts of rhizoma smilacis glabrae, 10 parts of rose, 30 parts of buffalo horn, 6 parts of liquorice, 15 parts of cassia twig and 15 parts of talcum.
3. The traditional Chinese medicine lotion according to claim 1, wherein the traditional Chinese medicine lotion is prepared by leaching the following raw materials in parts by weight with water: 20 parts of radix sophorae flavescentis, 20 parts of fructus cnidii, 20 parts of rhizoma smilacis glabrae, 15 parts of rose, 35 parts of buffalo horn, 10 parts of liquorice, 20 parts of cassia twig and 20 parts of talcum.
4. The Chinese medicinal lotion according to any one of claims 1 to 3, wherein the Chinese medicinal lotion is an extract obtained by leaching each raw material in a prescribed amount with 1 to 10 times by weight of water.
5. A method for preparing the traditional Chinese medicine lotion of claim 1, which is characterized by comprising the following steps:
1) extracting effective components:
soaking radix Sophorae Flavescentis in 4-10 times of water at room temperature for 1-3 hr, decocting for 2-3 times (30-45 min each time), and filtering to obtain radix Sophorae Flavescentis extractive solution;
decocting fructus Cnidii in 2-8 times of water for 2-3 times (30-45 min each time), and filtering to obtain fructus Cnidii extractive solution;
adding 2-8 times of water into rhizoma Smilacis Glabrae according to the prescription amount, soaking at room temperature for 1-3 hr, decocting for 2-3 times (30 min-45min each time), and filtering to obtain rhizoma Smilacis Glabrae extractive solution;
adding 2-8 times of water into the cassia twig according to the prescription amount, soaking for 1-3 hours at room temperature, decocting for 2-3 times, 30-45 min for each time, and filtering to obtain a cassia twig extract for later use;
2) preparation: mixing the extractive solutions in step 1), adding flos Rosae Rugosae, cornu Bubali, Glycyrrhrizae radix and pulvis Talci, decocting for 10-30 min for 1-2 times, filtering, collecting filtrate, bottling, sterilizing, capping, and packaging to obtain the Chinese medicinal lotion.
6. The use of the traditional Chinese medicine lotion of claim 1 in the preparation of a medicament for the treatment of perianal inflammation.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102526694A (en) * | 2012-03-14 | 2012-07-04 | 刘晓枫 | Lotion beneficial to health of anus and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526694A (en) * | 2012-03-14 | 2012-07-04 | 刘晓枫 | Lotion beneficial to health of anus and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 六一散用于肛周湿疹的疗效观察;计晓丽;《护理研究》;20070331;第21卷(第3期);第723页，尤其是第723页左栏第1、3段，右栏第1、3段 * |
| 外用六一散预防压疮的效果观察;周红玉;《中国实用医药》;20130831;第8卷(第23期);第215-216页 * |
| 狐惑病;陈桂铭;《湖南中医杂志》;19881231(第1期);第39-40页，尤其是第39页右栏第2、5段 * |
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