CN115634274A - Traditional Chinese medicine preparation for treating adenoidal hypertrophy of children and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating adenoidal hypertrophy of children and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating adenoid hypertrophy of children and a preparation method thereof, belonging to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine preparation comprises the following raw materials in parts by weight: 10-30 parts of cowherb seed, 30-45 parts of selfheal, 30-45 parts of raw oyster, 30-50 parts of perilla fruit, 18-38 parts of salvia miltiorrhiza, 12-32 parts of angelica tail, 15-35 parts of rhizoma sparganii, 10-30 parts of curcuma zedoary, 12-30 parts of rhizoma paridis, 18-38 parts of cocklebur fruit, 18-30 parts of magnolia flower, 18-36 parts of lance asiabell root and 18-39 parts of radix clematidis, and the preparation method is prepared by the steps of decocting, filtering, concentrating and the like. In the formula, selfheal is the essential drug for clearing fire and dissipating stagnation; fructus Perillae is effective in lowering qi, eliminating phlegm, and dredging collaterals; raw oyster shell can soften hardness and dissipate stagnation; the lance asiabell has the functions of detumescence, pus discharge and detoxification, cowherb seed, chinese angelica tail, common burreed rhizome, zedoary, stasis removal and vein relaxing, and the Chinese artichoke has the functions of heat detoxification, detumescence and pain relief, and the clematis has the functions of dredging channels and collaterals, phlegm elimination and salivation, nodule dispersing, cocklebur fruit and magnolia flower have the functions of easing nasal obstruction.
Description
Technical Field
The invention belongs to the technical field of preparation of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine preparation for treating adenoidal hypertrophy of children and a preparation method thereof.
Background
Under normal physiological conditions, the adenoid of children 4-6 years old develops to the maximum, gradually shrinks after puberty, disappears when the adenoid grows to be large, and causes corresponding symptoms such as long-term nasal obstruction, sleep suffocation, obstructive nasal sound when speaking, and increase of nasal discharge, namely adenoid proliferation or adenoid hypertrophy. It is formed due to repeated irritation of inflammation of the nasopharynx and its adjacent parts or adenoids themselves. Adenoids are very common in clinic, and if the adenoids are not treated in time, rhinitis and tracheitis can be caused, the growth and development of children can be influenced, and the problems of slow response of the children and the like can be caused.
At present, the treatment methods for the adenoid hypertrophy of children mainly comprise two methods, namely medicine and operation. The drug therapy mainly comprises nasal glucocorticoid drugs, such as mometasone furoate nasal spray, but the drug effect is not remarkable and long-term medication is required. Surgical treatments many parents are reluctant to do so because of the risks and high surgical costs.
Disclosure of Invention
The invention provides a traditional Chinese medicine preparation for treating adenoid hypertrophy of children and a preparation method thereof, aiming at solving the technical problems.
In order to solve the technical problems, the invention adopts the following technical scheme:
a traditional Chinese medicine preparation for treating adenoid hypertrophy of children comprises the following raw materials in parts by weight: 10-30 parts of cowherb seed, 30-45 parts of selfheal, 30-45 parts of raw oyster, 30-50 parts of perilla fruit, 18-38 parts of salvia miltiorrhiza, 12-32 parts of Chinese angelica tail, 15-35 parts of rhizoma sparganii, 10-30 parts of curcuma zedoary, 12-30 parts of rhizoma spatholobi, 18-38 parts of cocklebur fruit, 18-30 parts of magnolia flower, 18-36 parts of lance asiabell root and 18-39 parts of clematis root.
The feed comprises the following raw materials in parts by weight: 25 parts of cowherb seed, 34 parts of selfheal, 35 parts of raw oyster, 40 parts of perilla fruit, 28 parts of salvia miltiorrhiza, 19 parts of angelica tail, 28 parts of rhizoma sparganii, 25 parts of curcuma zedoary, 23 parts of rhizoma spatholobi, 23 parts of cocklebur fruit, 26 parts of magnolia flower, 30 parts of lance asiabell root and 28 parts of clematis root.
The preparation is sprayed or dropped 1-2 times per day in the morning, at noon and evening, 2-4 times per time.
The preparation is used for 30-45 days.
A preparation method of a traditional Chinese medicine preparation for treating adenoid hypertrophy of children comprises the following steps:
s1, weighing 35 parts of raw oyster, adding 8 times of water, and decocting for 0.5 hour;
s2, weighing the following raw materials in parts by weight: 25 parts of cowherb seed, 34 parts of selfheal, 40 parts of perilla fruit, 28 parts of salvia miltiorrhiza, 19 parts of angelica tail, 28 parts of rhizoma sparganii, 25 parts of curcuma zedoary, 23 parts of rhizoma paridis, 23 parts of cocklebur fruit, 26 parts of magnolia flower, 30 parts of lance asiabell root and 28 parts of radix clematidis, adding 8 times of water, soaking for 30 minutes, heating and decocting for 1.5 hours, filtering, and standing and precipitating the filtrate;
s3, adding 6 times of water into the medicine dregs in the step 2, decocting for 1.5 hours, filtering, combining the filtrate with the supernatant of the filtrate in the step 2, and concentrating to 60 ℃ to obtain an extract;
and S4, filtering the extract in the step 3, adding a preservative, and filling into a watering can to obtain the preparation.
The relative density of the extract is 1.05-1.10.
The preservative comprises benzyl alcohol.
The raw materials used in the invention have the following medicinal properties:
the cowherb seed has bitter taste and mild property, belongs to liver and stomach channels, and has the effects of activating blood circulation to promote menstruation, promoting lactation to reduce swelling, inducing diuresis to treat stranguria.
Spica Prunellae, pungent and bitter in flavor and cold in nature, enters liver and gallbladder meridians, and has the effects of clearing heat and purging fire, improving eyesight, resolving hard mass and relieving swelling.
Oyster, being salty in taste and neutral in nature, has the actions of strengthening the joints, killing pathogenic factors and prolonging life.
Perilla fruit, pungent in flavor and warm in nature, enters lung and large intestine meridians and has the effects of lowering qi, resolving phlegm, relieving cough and asthma, and relaxing bowel.
Salvia miltiorrhiza, bitter in taste and slightly cold in nature, enters heart and liver meridians, and has the effects of activating blood circulation to dissipate blood stasis, clearing meridians to stop pain, clearing heart fire, relieving restlessness, cooling blood and resolving carbuncle.
The Dang Gui Tail has the actions of activating blood and resolving stasis.
Rhizoma Sparganii, pungent and bitter in flavor, neutral in nature, enters liver and spleen meridians, and has effects of removing blood stasis, activating qi-flowing, resolving food stagnation and relieving pain.
Zedoary, pungent and bitter in flavor and warm in nature, entering liver and spleen meridians, has the effects of promoting qi circulation, removing blood stasis, resolving food stagnation and relieving pain.
The rhizoma paridis is bitter in taste and cold in nature, has little toxicity, enters heart channel, liver channel, lung channel, stomach channel and large intestine channel, and has the effects of detoxifying, resisting cancer, relieving swelling and pain, clearing heat, arresting convulsion, relieving cough and relieving asthma.
Fructus Xanthii, bitter, sweet and pungent in flavor, warm in nature, entering lung and liver meridians, has the effects of dispelling wind-cold, relieving stuffy nose, dispelling wind-damp and relieving pain.
Flos Magnoliae, pungent in flavor and warm in nature, enters lung and stomach meridians, and has the effects of dispelling wind-cold and relieving stuffy nose.
The lance asiabell root, sweet and pungent in flavor, neutral in nature, enters spleen and lung channels, and has the effects of benefiting qi, nourishing yin, detoxifying, relieving swelling, expelling pus and promoting lactation.
Clematis chinensis, pungent and salty in flavor and warm in nature, enters bladder meridian and has the effects of expelling wind-damp and dredging meridians and collaterals.
The invention has the advantages that: in the formula, the selfheal is the essential medicine for clearing fire and dispersing stagnation; perilla seed, fructus perillae lowers qi, reduces phlegm and unblocks collaterals; raw oysters soften hardness and dissipate stagnation; the lance asiabell has the functions of detumescence, pus discharge and detoxification, cowherb seed, chinese angelica tail, common burreed rhizome, zedoary, stasis removal and vein relaxing, and the Chinese artichoke has the functions of heat detoxification, detumescence and pain relief, and the clematis has the functions of dredging channels and collaterals, phlegm elimination and salivation, nodule dispersing, cocklebur fruit and magnolia flower have the functions of easing nasal obstruction.
The traditional Chinese medicine spray prepared by the invention is reasonable in formula and synergistic in medicines, is used for treating adenoidal hypertrophy of children, and has obvious effect compared with the existing nasal glucocorticoid medicines.
The mechanism of the invention is as follows: through local administration, the medicine can dissipate stagnation, remove stasis and detumescence, reduce adenoids and make the nasopharynx smooth in breathing, thereby eliminating the symptom of snore of children.
Detailed Description
In order to facilitate a better understanding of the invention, reference is made to the following examples, which are included to illustrate, but not to limit the scope of the invention.
Example 1
A traditional Chinese medicine preparation for treating adenoid hypertrophy of children comprises the following raw materials in parts by weight: 10 parts of cowherb seed, 30 parts of common selfheal fruit-spike, 30-50 parts of perilla fruit, 18 parts of salvia miltiorrhiza, 12 parts of Chinese angelica tail, 15 parts of common burreed rhizome, 10 parts of zedoary, 12 parts of Chinese artichoke, 18 parts of cocklebur fruit, 18 parts of biond magnolia flower, 18 parts of lance asiabell root and 18 parts of clematis root.
A preparation method of a traditional Chinese medicine preparation for treating adenoid hypertrophy of children comprises the following steps:
s1, weighing 30 parts of raw oyster, adding 8 times of water, and decocting for 0.5 hour;
s2, weighing the following raw materials in parts by weight: 25 parts of cowherb seed, 34 parts of selfheal, 40 parts of perilla fruit, 28 parts of salvia miltiorrhiza, 19 parts of angelica tail, 28 parts of rhizoma sparganii, 25 parts of curcuma zedoary, 23 parts of rhizoma paridis, 23 parts of cocklebur fruit, 26 parts of magnolia flower, 30 parts of lance asiabell root and 28 parts of radix clematidis, adding 8 times of water, soaking for 30 minutes, heating and decocting for 1.5 hours, filtering, and standing and precipitating the filtrate;
s3, adding 6 times of water into the medicine residues in the step 2, decocting for 1.5 hours, filtering, combining the filtrate with the supernatant of the filtrate in the step 2, and concentrating to 60 ℃ to obtain an extract;
and S4, filtering the extract in the step 3, adding a preservative, and filling into a watering can to obtain the preparation.
The preparation is sprayed or dropped 2 times per day in the morning, at noon and evening, each time for 2 times.
The preparation has a service time of 40 days.
The relative density of the extract is 1.05.
The preservative comprises sodium benzoate.
Example 2
A traditional Chinese medicine preparation for treating adenoid hypertrophy of children comprises the following raw materials in parts by weight: 25 parts of cowherb seed, 34 parts of selfheal, 35 parts of raw oyster, 40 parts of perilla fruit, 28 parts of salvia miltiorrhiza, 19 parts of angelica tail, 28 parts of rhizoma sparganii, 25 parts of curcuma zedoary, 23 parts of rhizoma paridis, 23 parts of cocklebur fruit, 26 parts of magnolia flower, 30 parts of lance asiabell root and 28 parts of clematis root.
A preparation method of a traditional Chinese medicine preparation for treating adenoid hypertrophy of children comprises the following steps:
s1, weighing 35 parts of raw oysters, adding 8 times of water, and decocting for 0.5 hour;
s2, weighing the following raw materials in parts by weight: 25 parts of cowherb seed, 34 parts of selfheal, 40 parts of perilla fruit, 28 parts of salvia miltiorrhiza, 19 parts of angelica tail, 28 parts of rhizoma sparganii, 25 parts of curcuma zedoary, 23 parts of rhizoma paridis, 23 parts of cocklebur fruit, 26 parts of magnolia flower, 30 parts of lance asiabell root and 28 parts of radix clematidis, adding 8 times of water, soaking for 30 minutes, heating and decocting for 1.5 hours, filtering, and standing and precipitating the filtrate;
s3, adding 6 times of water into the medicine residues in the step 2, decocting for 1.5 hours, filtering, combining the filtrate with the supernatant of the filtrate in the step 2, and concentrating to 60 ℃ to obtain an extract;
s4, filtering the extractum in the step 3, adding a preservative, and filling into a spray can to prepare the preparation.
The preparation is sprayed or dropped 1 time every morning, evening and evening, and 2 times every day.
The preparation is used for 30 days.
The relative density of the extract was 1.08.
The preservative comprises sodium benzoate.
Example 3
A traditional Chinese medicine preparation for treating adenoid hypertrophy of children comprises the following raw materials in parts by weight: 30 parts of cowherb seed, 45 parts of selfheal, 45 parts of raw oyster, 50 parts of perilla fruit, 38 parts of salvia miltiorrhiza, 32 parts of angelica tail, 35 parts of rhizoma sparganii, 30 parts of curcuma zedoary, 30 parts of rhizoma spatholobi, 38 parts of cocklebur fruit, 30 parts of magnolia flower, 36 parts of lance asiabell root and 39 parts of clematis root.
A preparation method of a traditional Chinese medicine preparation for treating adenoid hypertrophy of children comprises the following steps:
s1, weighing 45 parts of raw oyster, adding 8 times of water, and decocting for 0.5 hour;
s2, weighing the following raw materials in parts by weight: 30 parts of cowherb seed, 45 parts of selfheal, 50 parts of perilla fruit, 38 parts of salvia miltiorrhiza, 32 parts of angelica tail, 35 parts of rhizoma sparganii, 30 parts of curcuma zedoary, 30 parts of rhizoma spatholobi, 38 parts of cocklebur fruit, 30 parts of magnolia flower, 36 parts of lance asiabell root and 39 parts of radix clematidis, 8 times of water is added, after the mixture is soaked for 30 minutes, the mixture is heated and decocted for 1.5 hours, filtered, and the filtrate is kept stand and precipitated;
s3, adding 6 times of water into the medicine dregs in the step 2, decocting for 1.5 hours, filtering, combining the filtrate with the supernatant of the filtrate in the step 2, and concentrating to 60 ℃ to obtain an extract;
s4, filtering the extractum in the step 3, adding a preservative, and filling into a spray can to prepare the preparation.
The relative density of the extract is 1.10.
Preservatives include sorbic acid.
The preparation is sprayed or dropped 1 time every morning, evening and evening, and 2 times every day.
The preparation is used for 45 days.
3. Clinical trial
1. General data
50 children with clinic diagnosis of adenoid hypertrophy are selected and randomly divided into a test group and a control group, and each group comprises 25 children. Wherein, 12 cases of boys and 13 cases of girls in the test group are aged 4-10 years, the average age is (7.4 + 2.2) years, 55-80% of nostrils are formed after adenoid obstruction of rhinoscopy, and the average age is (67 + 8.7)%; 11 cases of boys and 14 cases of girls in the control group, age 4-11 years, mean age (7.5 + 2.2) years, 50-80% of nostrils after adenoid blockage of rhinoscopy and mean (66.2 + 8.9)%. The general data comparison of two groups of patients shows that the difference is not statistically significant (P > 0.5) and is comparable.
2. Method of treatment
The test group is treated by the traditional Chinese medicine preparation of the embodiment 2 of the invention, and the traditional Chinese medicine preparation is continuously taken for 30 days by spraying or dripping 1 time in the morning and evening and 2 times each time.
The control group was sprayed with a commercially available mometasone furoate nasal spray 1 time at night for 30 consecutive days.
3. Evaluation of Effect
Observing the treatment effect and the incidence rate of adverse reaction of two groups of patients, and judging the treatment effect:
(1) the method has the following advantages: after treatment, clinical symptoms are completely eliminated, and nasal endoscopy shows that the nostril is less than 10% after adenoid blockage;
(2) the effect is shown: after treatment, clinical symptoms are obviously relieved, and the nasal endoscopy shows that the nostrils are 10-30% after the adenoid is blocked;
(3) and (4) invalidation: after treatment, the clinical symptoms are unchanged, and the nasal endoscopy shows that the proportion of nostrils is unchanged after adenoid blockage, and even the disease condition is aggravated.
4. Statistical treatment
Data processing and analysis were performed using SPSS statistical software and two sets of clinical efficacy comparisons were calculated, both expressed in% form. When P <0.05, the difference was statistically significant.
5. As a result, the
The total effective rate of the experimental group is 97%, the total effective rate of the control group is 70%, and the two groups have obvious difference, wherein P is less than 0.05. During the treatment period, no adverse reaction occurs in the two groups.
Wherein the total effective = (effective + efficacious)/(effective + efficacious + ineffective) × 100%
The clinical trial data are detailed in table 3.
TABLE 3 data summary of two clinical trials
| Group of | n | Is effective | Show effect | Invalidation | Total apparent effect |
| Test group | 25 | 32％ | 64％ | 4％ | 84％ |
| Control group | 25 | 4％ | 12％ | 84％ | 16％ |
6. Conclusion
The data in table 3 show that the effective rate of the traditional Chinese medicine preparation for treating snoring is 32%, the total significant efficiency is 84%, and the effect is particularly obvious compared with the effective rate of 4% and the total significant efficiency of 16% in the control group. Therefore, the test group has higher efficiency and efficiency than the control group, and the statistical treatment shows that the difference has statistical significance (P < 0.05), and the clinical score of the two groups of children patients after treatment and the comparison difference between the A/N ratio groups have statistical significance (P < 0.05).
In conclusion, the traditional Chinese medicine preparation for treating the adenoidal hypertrophy of the children has obvious effect compared with the existing nasal glucocorticoid medicines.
The present invention is not limited to the above preferred embodiments, and any modifications, equivalents and improvements made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (7)
1. The traditional Chinese medicine preparation for treating adenoid hypertrophy of children is characterized by comprising the following raw materials in parts by weight: 10-30 parts of cowherb seed, 30-45 parts of selfheal, 30-45 parts of raw oyster, 30-50 parts of perilla fruit, 18-38 parts of salvia miltiorrhiza, 12-32 parts of angelica tail, 15-35 parts of rhizoma sparganii, 10-30 parts of curcuma zedoary, 12-30 parts of rhizoma paridis, 18-38 parts of cocklebur fruit, 18-30 parts of magnolia flower, 18-36 parts of lance asiabell root and 18-39 parts of clematis root.
2. The traditional Chinese medicine preparation for treating adenoid hypertrophy of children according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 25 parts of cowherb seed, 34 parts of selfheal, 35 parts of raw oyster, 40 parts of perilla fruit, 28 parts of salvia miltiorrhiza, 19 parts of angelica tail, 28 parts of rhizoma sparganii, 25 parts of curcuma zedoary, 23 parts of rhizoma paridis, 23 parts of cocklebur fruit, 26 parts of magnolia flower, 30 parts of lance asiabell root and 28 parts of clematis root.
3. The traditional Chinese medicine preparation for treating adenoid hypertrophy of children as claimed in claim 2, wherein the preparation is sprayed or dripped 1-2 times per day in the morning, at noon and at night, and 2-4 times per day on the affected part.
4. The traditional Chinese medicine preparation for treating adenoidal hypertrophy of children as claimed in claim 3, wherein the preparation is used for 30-45 days.
5. A preparation method of a traditional Chinese medicine preparation for treating adenoid hypertrophy of children is characterized by comprising the following steps:
s1, weighing 35 parts of raw oysters, adding 8 times of water, and decocting for 0.5 hour;
s2, weighing the following raw materials in parts by weight: 25 parts of cowherb seed, 34 parts of selfheal, 40 parts of perilla fruit, 28 parts of salvia miltiorrhiza, 19 parts of angelica tail, 28 parts of rhizoma sparganii, 25 parts of curcuma zedoary, 23 parts of rhizoma paridis, 23 parts of cocklebur fruit, 26 parts of magnolia flower, 30 parts of lance asiabell root and 28 parts of radix clematidis, adding 8 times of water, soaking for 30 minutes, heating and decocting for 1.5 hours, filtering, and standing and precipitating the filtrate;
s3, adding 6 times of water into the medicine residues in the step 2, decocting for 1.5 hours, filtering, combining the filtrate with the supernatant of the filtrate in the step 2, and concentrating to 60 ℃ to obtain an extract;
and S4, filtering the extract in the step 3, adding a preservative, and filling into a watering can to obtain the preparation.
6. The preparation method of the traditional Chinese medicine preparation for treating adenoid hypertrophy of children as claimed in claim 5, wherein the relative density of the extract is 1.02-1.10.
7. The method for preparing a Chinese medicinal preparation for treating adenoid hypertrophy of children according to claim 5, wherein the preservative comprises sorbic acid or sodium benzoate.
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| CN116870122A (en) * | 2023-08-22 | 2023-10-13 | 长春中医药大学 | Traditional Chinese medicine composition for treating pediatric adenoid hypertrophy and application thereof |
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| CN116870122B (en) * | 2023-08-22 | 2024-04-05 | 长春中医药大学 | Traditional Chinese medicine composition for treating pediatric adenoid hypertrophy and application thereof |
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