CN112891425A

CN112891425A - Traditional Chinese medicine composition for ascending the clear, descending the turbid and benefiting the spleen

Info

Publication number: CN112891425A
Application number: CN202110407263.4A
Authority: CN
Inventors: 张义
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-04-15
Filing date: 2021-04-15
Publication date: 2021-06-04

Abstract

The invention discloses a traditional Chinese medicine composition for ascending the clear and descending the turbid, which comprises the following components in parts by weight: 2 parts of radix bupleuri, 2 parts of rhizoma cimicifugae, 3 parts of radix astragali, 2 parts of lotus leaf, 1 part of cassia twig, 2 parts of fructus aurantii, 2 parts of rhizoma coptidis, 2 parts of rhizoma atractylodis macrocephalae, 2 parts of poria cocos, 1 part of ginseng, 1 part of liquorice, 1 part of starch and 3 parts of agar; the prescription treats the diarrhea caused by dysfunction of spleen and stomach and invasion of pathogenic factors, and the principle of treating the diarrhea is as follows: by ascending the clear and descending the turbid, namely, the spleen should ascend and the stomach should descend, the compatibility of the cassia twig and the coptis in the formula is favorable for improving the intestinal function, the cassia twig warms the channel and dredges the collaterals, the congestion and the edema of intestinal mucosa can be reduced, and the coptis clears away heat, promotes diuresis and stops diarrhea; cimicifugae rhizoma, bupleuri radix, and folium Nelumbinis have the effects of invigorating qi, fructus Aurantii is used for removing filth of gastrointestinal foul qi, and radix Ginseng, Atractylodis rhizoma, Poria, Glycyrrhrizae radix, and radix astragali with effects of invigorating spleen, replenishing qi and invigorating spleen are added.

Description

Traditional Chinese medicine composition for ascending the clear, descending the turbid and benefiting the spleen

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for ascending the clear, descending the turbid and benefiting the spleen.

Background

The diarrhea disease is a digestive tract disease which is caused by various pathogens and various factors and has the characteristics of increasing stool frequency and changing stool characters, the common treatment mode adopted by western medicine is to supplement water to prevent dehydration, and simultaneously montmorillonite powder is matched for treatment, although the corresponding treatment mode is required for diarrhea caused by special conditions, the situation is not in the discussion range of the application, the montmorillonite is a silicate body, crystals are in a layered structure, and like waffles which are frequently eaten by people, the montmorillonite has a huge surface area, 3g of montmorillonite can cover the whole gastrointestinal wall of normal adults, and can last for more than 6 hours, and the common dosage of the adults is as follows: 3g each time, 3 times a day, in addition, the montmorillonite also has uneven charge distribution, can absorb, fix and inhibit charged viruses, particularly rotavirus germs, escherichia coli, vibrio cholerae, helicobacter pylori and mould, and toxin adsorption generated by the viruses, and the montmorillonite powder also has a covering effect on the mucous membrane of the digestive tract, a layer of protective screen is manufactured for the digestive tract of people, and the defense capability of the digestive tract to attack factors is greatly improved, so that the antidiarrheal effect is exerted.

The traditional Chinese medicine for treating diarrhea is mainly characterized in that: the traditional Chinese medicine has the main effects of clearing heat and promoting diuresis, strengthening spleen and replenishing qi, warming middle-jiao and dispelling cold, warming kidney and dispelling cold, relieving diarrhea with astringents and the like, and can achieve a certain treatment effect, but the applicant finds in practice that the illness state treated by the treatment method is easy to repeat, and the traditional Chinese medicine theory considers that: the stomach governs accepting rotten food, and the spleen governs transporting and resolving water dampness and absorbing food essence, so that the ascending and descending functions of the spleen and stomach cannot be influenced: the stomach is descending and the spleen is ascending. If the spleen and stomach are affected by diseases, the spleen and stomach are disadvantaged in ascending, descending, transformation and absorption, so that after the food enters the stomach, food is not transformed, essence cannot be absorbed, turbid and clear are not separated, and diarrhea is caused by combined dirt, and the reason why the diarrhea is repeated is that: the dysfunction of spleen and stomach in ascending and descending is not treated, and the function is not radically recovered, for example, the Chinese book entitled "Su Wen Bing Ji Yi Bao Ming Ji" discloses a peony decoction, which comprises the following specific components: the formula is one of the commonly used clinical formulas, but after the formula is used, the formula has a good antidiarrheal effect, but the disease condition is easy to repeat.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition for ascending the clear, descending the turbid and benefiting the spleen, which is used for solving the acute and chronic diarrhea and the acute gastritis caused by dysfunction of the spleen and the stomach, and can simultaneously play a role in oral administration and external application to fully play the efficacy.

In order to achieve the purpose, the invention adopts the following technical scheme:

a traditional Chinese medicine composition for ascending the clear, descending the turbid and benefiting the spleen is composed of the following components in parts by weight: 2 parts of radix bupleuri, 2 parts of rhizoma cimicifugae, 3 parts of radix astragali, 2 parts of lotus leaf, 1 part of cassia twig, 2 parts of fructus aurantii, 2 parts of rhizoma coptidis, 2 parts of rhizoma atractylodis macrocephalae, 2 parts of poria cocos, 1 part of ginseng and 1 part of liquorice.

Further, still include: 1 part of starch and 3 parts of agar.

Further, crushing the medicinal materials by a crusher, putting the crushed medicinal materials into a decocting vessel, decocting for a plurality of hours, filtering out dregs of a decoction to obtain a decoction, and directly taking the decoction orally.

Further, crushing the above medicinal materials with a pulverizer, decocting in a decocting vessel for several hours, filtering to remove residues to obtain decoction, and cooling at 0-8 deg.C to obtain jelly.

The invention has at least the following beneficial effects:

(1) treats both principal and secondary aspects of diseases, breaks through the limitation of the traditional treatment, and has the function of promoting the recovery of intestinal functions while treating diarrhea by selecting medicines.

(2) Ascending the clear and descending the turbid, invigorating the spleen to arrest diarrhea, fundamentally solving the problem of diarrhea by adjusting the dysfunction of viscera, and breaking through the traditional method of mainly arresting diarrhea.

(3) The preparation can be taken orally and also used for external application, and the starch and agar powder in the preparation can improve the viscosity and the adhesive force of the preparation when being applied externally, and can effectively contact with the skin to exert the drug property.

Detailed Description

It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the disclosure; unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present application; as used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise.

In addition, the dosage referred to in this application is the dosage obtained by normal adults for example, and the dosage mentioned in the following examples and comparative examples is only an exemplary illustration, and those skilled in the art need to increase or decrease the dosage according to different conditions of patients in a specific time.

Examples

The traditional Chinese medicine composition comprises the following components in parts by weight: 2 parts of radix bupleuri, 2 parts of rhizoma cimicifugae, 3 parts of radix astragali, 2 parts of lotus leaf, 1 part of cassia twig, 2 parts of fructus aurantii, 2 parts of rhizoma coptidis, 2 parts of rhizoma atractylodis macrocephalae, 2 parts of poria cocos, 1 part of ginseng, 1 part of liquorice, 1 part of starch and 3 parts of agar;

the usage and dosage are as follows: in the example, one part by weight represents 5g, three times a day, one dose is given at a time, and the obtained liquid medicine is divided into two parts, one part is taken orally, and the other part is taken externally.

The prescription treats the diarrhea caused by dysfunction of spleen and stomach and invasion of pathogenic factors, and the principle of treating the diarrhea is as follows: by ascending the clear and descending the turbid, namely, the spleen should ascend and the stomach should descend, the compatibility of the cassia twig and the coptis in the formula is favorable for improving the intestinal function, the cassia twig warms the channel and dredges the collaterals, the congestion and the edema of intestinal mucosa can be reduced, and the coptis clears away heat, promotes diuresis and stops diarrhea; cimicifugae rhizoma, bupleuri radix, and folium Nelumbinis have the effects of invigorating qi, fructus Aurantii is used for removing filth of gastrointestinal foul qi, and radix Ginseng, Atractylodis rhizoma, Poria, Glycyrrhrizae radix, and radix astragali with effects of invigorating spleen, replenishing qi and invigorating spleen are added.

More importantly: the formula of the embodiment can be used as an external medicine under the condition of not changing the formula of the formula even though the formula is used for oral administration, and the oral administration and the external application are usually carried out simultaneously when the formula is used, so that a better using effect can be achieved.

The decoction method of the oral medicine is the same as the prior art, namely the medicinal materials are crushed by a crusher and then put into a decoction vessel for decocting for several hours, and dregs of a decoction are filtered to obtain decoction which is taken at 20-30 ℃; when the solid medicament is used as an external medicament, the solid medicament is easier to lay compared with the traditional medicament, the traditional medicament for soup can be dried after several hours, the acting time is short, the gel medicament has more water stored in the gel, the liquid medicament can exert the drug effect for a longer time, and the two coagulants can be eaten by themselves, so the external medicament for soup and the internal medicament for soup are simultaneously used for external application and internal administration, the decoction is used at the same time without separate preparation, and the combined use of the two can achieve better use effect, thereby further consolidating the curative effect.

Comparative example 1

The components of the medicine are as follows: 3g of montmorillonite, sucrose (octahedral montmorillonite fine particles as main ingredient, the powder particle size is 1-3 μm)

The usage and dosage are as follows: one dose is taken three times a day.

Comparative example 2

Respectively taking 11 parts of dry purslane, 8 parts of gordon euryale seed, 7 parts of costus root, 3 parts of platycodon root, 3 parts of radix bupleuri, 9 parts of akebia stem, 5 parts of plantain seed, 8 parts of hispid fig, 6 parts of liriope spicata and 3 parts of bitter orange according to the weight, decocting according to the prior art, and cooling the obtained decoction for taking.

Comparative example 3

The Dinggui navel paste comprises the following components: flos Caryophylli, cortex Cinnamomi, fructus Piperis Longi, and adjuvants including vaseline, laurocapram, glycerol, paraffin, and lanolin.

The usage and dosage are as follows: one patch at a time, and the patch is replaced once in 24 hours.

Experimental example 1

General data:

dividing the patients who are treated in 2017 in 9-2021 in 3 according to the four different treatment modes, randomly selecting 20 patients from the four categories to form an example group, a control example 1 group, a control example 2 group and a control example 3 group, wherein the example group selects 20 patients according to the different use modes and the patients are selected according to the pure oral administration, the pure external application and the dual use, and the total number of the patients is 120:

example set:

pure oral administration: 12 men and 8 women, with a mean age of 35.2 years and a mean course of 3.6 days;

pure external use: 9 men and 11 women, with a mean age of 20.6 years and a mean course of 4.2 days;

dual-purpose group: 10 men and 10 women, the average age is 40.2 years, and the average course is 6.3 days;

control example 1 group:

male 13, female 7, mean age: 37.6 years old, mean course of disease 5.3 days;

control example 2 group:

9 men and 11 women, with a mean age of 30.2 years and a mean course of 4.2 days;

control example 2 group:

12 men and 8 women, with an average age of 21.6 years and an average course of 3.8 days;

the sex, age, course of disease and the like of the patients in the groups have comparative differences, have no statistical significance and are comparable.

Integration of symptom signs:

the integration is carried out according to the five main symptoms of the times of attack of abdominal pain and diarrhea, weight change, hypodynamia, insomnia and appetite, and the main symptoms and the secondary symptoms are respectively counted for 0, 2, 4 and 6 points according to the absence, the mild degree, the moderate degree and the severe degree.

And (3) judging the curative effect:

(1) the clinical cure is as follows: abdominal pain and diarrhea disappear, and the patient feels insomnia and has no allergic symptoms outside the intestinal tract;

(2) the effect is shown: the total integral of symptoms and signs of abdominal pain and diarrhea is reduced by more than 70 percent compared with that before treatment;

(3) the method has the following advantages: the abdominal pain and diarrhea are reduced by half, and the total integral of accompanying symptoms and signs is reduced by more than 35 percent compared with that before treatment;

(4) and (4) invalidation: those which do not meet the above criteria.

Results of the experiment

TABLE 1 results of comparison of clinical efficacy of patients taking oral drugs

Group of	Number of examples	Recovery method	Show effect	Is effective	Invalidation	Total effective rate/%)
							Example set (internal garment)	20	5	8	3	4	80.0
Comparative example 1	20	9	6	3	2	90.0
							Comparative example 2	20	7	6	4	3	85.0
Comparative example 3	20	6	7	3	4	80.0

TABLE 2 results of comparison of clinical effects of patients taking oral drugs

Group of	Number of examples	Recovery method	Show effect	Is effective	Invalidation	Total effective rate/%)
							Example set (for external use)	20	3	8	4	5	75.0
Comparative example 3	20	6	7	3	4	80.0

TABLE 3 patient before and after treatment clinical symptom score comparison

Group of	Number of examples	Before treatment	After treatment
				Example set (internal garment)	20	18.2	8.8
Example set (for external use)	20	16.2	8.6
				Example group (Dual use)）	20	18.8	6.4
Comparative example 1	20	18.8	7.8
				Comparative example 2	20	18.2	7.6
Comparative example 3	20	16.6	8.4

Analysis of results

According to the content in table 1, it can be known that the variables in the table mainly lie in different groups, and different groups have different medicament formulas, and it can be found through the above experiments that the above medicaments can achieve better treatment effects, and the total effective rates are all 80% or more, wherein the treatment effect is the best for the patient treated by the comparative example 2, and the patient treated by the traditional Chinese medicine also has better treatment effect, relatively, the treatment effect of the external application type treatment method adopted in the comparative example 3 is poorer, mainly because the external application type administration is applied to the affected part for a longer time, the effect is poorer than the internal application type administration, but the external application type administration is better in use experience, and the taste of the medicament is not needed to be endured.

Table 2 shows that the external preparation for treating diarrhea, mainly applied, is only the external preparation of comparative example 3 and the external preparation of the examples, which have the external application function, have the same effects, and the curative ratio is different because the two preparations are applied to intestines and stomach by external administration.

Table 3 shows that the difference between different patients is reduced by referring to different symptoms of the patients in the form of an integral table, in the experiment, the clinical symptoms described by the patients are used and divided into five common symptoms of attack times, weight change, hypodynamia, insomnia and appetite, so that the disease conditions of different patients are quantified, the deviation of the experiment is reduced, all six experimental groups are put together for comparison, and the table 1-2 shows that the traditional oral Chinese medicine and western medicine represented by the comparison examples 1 and 2 always have good using effect in the actual use, the external navel patch has relatively poor treating effect, the specific using effect of the oral group in the example group is poorer than that of the comparison examples 1 and 2, and the specific using effect of the external group in the example group is equivalent to that of the comparison example 3, and is more superior to that of the comparison example 1, 2, however, the using effect of the dual-purpose group in the example group is far better than that of the single oral administration or the single external application, and is better than that of the comparative examples 1 and 2, and the difference of the three groups in the example group is only the difference of the using modes, so that the traditional Chinese medicine composition prepared by the formula in the example can obtain better using effect by matching with the two using modes of the oral administration and the external application.

Although the invention has been described in detail with respect to the general description and the specific embodiments, it will be apparent to those skilled in the art that modifications or improvements may be made thereto without departing from the spirit of the invention.

Claims

1. A traditional Chinese medicine composition for ascending the clear, descending the turbid and benefiting the spleen is characterized in that: the composition comprises the following components in parts by weight:

2 portions of bupleurum root,

2 portions of cimicifuga foetida,

3 parts of astragalus root,

2 parts of lotus leaf,

1 part of cassia twig,

2 parts of bitter orange,

2 parts of coptis root,

2 portions of white atractylodes rhizome,

2 portions of tuckahoe,

1 part of ginseng,

1 part of liquorice.

2. The traditional Chinese medicine composition for ascending the clear, descending the turbid and benefiting the spleen according to claim 1, which is characterized in that: further comprising:

1 part of starch,

And 3 parts of agar.

3. The traditional Chinese medicine composition for ascending the clear, descending the turbid and benefiting the spleen according to claim 2, which is characterized in that: pulverizing the above materials with a pulverizer, decocting in a decocting vessel for several hours, filtering to remove residues to obtain decoction, and directly administering orally.

4. The traditional Chinese medicine composition for ascending the clear, descending the turbid and benefiting the spleen according to claim 2, which is characterized in that: pulverizing the above materials with a pulverizer, decocting in a decocting vessel for several hours, filtering to remove residues to obtain decoction, and cooling at 0-8 deg.C to obtain jelly for external application.