CN111840383A - Targeted spray moxibustion composition for treating rheumatic arthritis and preparation and use methods thereof - Google Patents

Targeted spray moxibustion composition for treating rheumatic arthritis and preparation and use methods thereof Download PDF

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Publication number
CN111840383A
CN111840383A CN202010853302.9A CN202010853302A CN111840383A CN 111840383 A CN111840383 A CN 111840383A CN 202010853302 A CN202010853302 A CN 202010853302A CN 111840383 A CN111840383 A CN 111840383A
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Prior art keywords
moxibustion
pot
root
composition
radix
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Chinese (zh)
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刘东泰
王奎荣
张小炎
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Individual
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    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents

Abstract

The invention relates to a targeted moxibustion composition for treating rheumatic arthritis, which comprises a pot A and a pot B, wherein the pot A comprises Kunlun Muyu powder, radix angelicae pubescentis, pseudo-ginseng and the like, and the pot B comprises cassia twig, eupolyphaga, medicinal cyathula root and the like. Adding auxiliary materials into the traditional Chinese medicine components, stirring uniformly, adding the mixture into a specific container, sealing with yellow mud, baking at 35-65 ℃, then carrying out low-temperature ultra-micro nano-nano pulverization, diluting with high-boron deuterium-depleted water, pressurizing, filling and preparing into spray. The invention firstly sprays A pot on Shenshu, Zhongwan and Shenque acupoints, adopts sparrow pecking moxibustion and mild moxibustion to carry out moxibustion alternately, and then sprays B pot on the pain position for moxibustion. The Kunlun Muyu powder is specially added, so that the cell microcirculation can be improved, the nutrient absorption is promoted, other nano-scale traditional Chinese medicine particles are directly absorbed through skin penetration, the effective components of the medicine are quickly permeated through the spray moxibustion therapy, and the traditional Chinese medicine composition has a good treatment effect on the rheumatic arthritis.

Description

Targeted spray moxibustion composition for treating rheumatic arthritis and preparation and use methods thereof
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to a targeted moxibustion composition for treating rheumatic arthritis and preparation and use methods thereof.
Background
Rheumatoid arthritis is a common acute or chronic inflammation of connective tissue characterized by wandering soreness and redness and swelling of joints and muscles. The joint is characterized in that phalanges are tightly connected with each other by virtue of dense fibrous connective tissues, joint surfaces at the joint of the phalanges are generally a convex surface and a concave surface, a closed joint cavity is formed in the middle of the phalanges, joint liquid is contained in the joint cavity, and when the joint is diseased, the liquid in the joint cavity is increased to form joint effusion and swelling. The closed structure of the joint makes traditional medicines difficult to enter, which is the root cause of stubborn and intractable rheumatoid arthritis. Most western medicines relieve pain through paralysis, and have no specific effect on treating symptoms and root causes, and the treatment of the rheumatoid arthritis is not available.
Therefore, the treatment medicine and the treatment method thereof which solve the root problems, have good effects and no side effects are urgently needed by the majority of patients with the rheumatic arthritis.
Disclosure of Invention
Aiming at the technical background, the technical problem to be solved by the invention is to provide a targeted moxibustion spraying composition for treating rheumatic arthritis, which adopts a direct transdermal absorption mode, Kunlun Cuiyu powder in a tank A can improve cell microcirculation and promote drug absorption, is matched with nano-scale traditional Chinese medicine particles in a tank B to directly act on pain parts in a targeted mode, and combines the moxibustion spraying therapy to quickly permeate active ingredients of the medicine, enhance the drug effect and achieve better effect.
In order to solve the technical problems, the invention adopts the technical scheme that:
a targeted spray moxibustion composition for treating rheumatic arthritis comprises jar A and jar B, wherein jar A comprises Kunlun Muyu powder, radix Angelicae Pubescentis, radix Notoginseng, radix Angelicae sinensis, flos Carthami, ramulus Cinnamomi, radix Clematidis, herba Taxilli, cortex Eucommiae, radix Angelicae Dahuricae, herba asari, radix Paeoniae alba, and radix astragali, jar B comprises ramulus Cinnamomi, Eupolyphaga Seu Steleophaga, radix Cyathulae, radix Achyranthis bidentatae, rhizoma Atractylodis, herba Ephedrae, Bombyx Batryticatus, Olibanum, Myrrha, Pyritum preparata, radix Angelicae sinensis, flos Carthami, rhizoma Ligustici Chuanxiong, cortex Schizophragmatis Integrifolii Radicis, rhizoma Notopterygii, rhizoma Zingiberis, radix Stephaniae Tetrandrae, radix Clematidis, fructus Lycii, cortex Eucommiae, radix Gentianae Macrophyllae, rhizoma homalomenae, rhizoma arisaematis, Siegesbeckiae herba, fructus Chaenomelis, Lumbricus, radix Angelicae Pubescentis, radix Dipsaci.
Preferably, the components are mixed according to the parts by weight:
and (4) tank A:
Figure BDA0002645537540000011
Figure BDA0002645537540000021
and (4) tank B:
Figure BDA0002645537540000022
a preparation method of a targeted moxibustion composition for treating rheumatoid arthritis comprises the following steps:
s01: baking with slow fire: weighing the components of the composition according to the weight part ratio, cleaning, adding auxiliary materials, stirring uniformly, adding into a container fired by adding clay, medical stone powder and jasper powder, sealing with yellow mud, and baking in a baking room at 35-65 ℃;
s02: nano-crushing: adding high-boron deuterium-depleted water, and micronizing at 25 deg.C to obtain suspension containing Chinese medicinal particles with nanometer particle size;
s03: and (3) sterilization and filling: short-time microwave sterilization, high-boron deuterium-depleted water dilution, pressurization filling and spray preparation.
Preferably, the auxiliary materials in the S01 include one or more of honey, yellow wine, bran, salt and vinegar.
A targeted spray moxibustion composition for treating rheumatic arthritis is prepared by spraying pot A on Shenshu, Zhongwan and Shenque acupoints, alternately performing moxibustion by sparrow pecking and mild moxibustion for 10-30 min, and spraying pot B on the pain area for 10-30 min.
The invention has the advantages that:
(1) the specially added Kunlun jasper powder has the effect of improving cell microcirculation and promotes the absorption capacity of cells to medicinal components;
(2) the traditional Chinese medicine components are baked by slow fire to increase the drug effect, and then are pulverized at low temperature to be nano-scale particle size, so that the traditional Chinese medicine components can be directly absorbed through skin;
(3) the invention adopts the combination of the pot A and the pot B, which can cure and maintain the disease, consolidate the curative effect and prevent the recurrence.
Detailed Description
The technical solution of the present invention is described below clearly and completely with reference to specific embodiments, and it is obvious that the described embodiments are only some embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention provides a technical scheme that: a targeted spray moxibustion composition for treating rheumatic arthritis comprises jar A and jar B, wherein jar A comprises Kunlun Muyu powder, radix Angelicae Pubescentis, radix Notoginseng, radix Angelicae sinensis, flos Carthami, ramulus Cinnamomi, radix Clematidis, herba Taxilli, cortex Eucommiae, radix Angelicae Dahuricae, herba asari, radix Paeoniae alba, and radix astragali, jar B comprises ramulus Cinnamomi, Eupolyphaga Seu Steleophaga, radix Cyathulae, radix Achyranthis bidentatae, rhizoma Atractylodis, herba Ephedrae, Bombyx Batryticatus, Olibanum, Myrrha, Pyritum preparata, radix Angelicae sinensis, flos Carthami, rhizoma Ligustici Chuanxiong, cortex Schizophragmatis Integrifolii Radicis, rhizoma Notopterygii, rhizoma Zingiberis, radix Stephaniae Tetrandrae, radix Clematidis, fructus Lycii, cortex Eucommiae, radix Gentianae Macrophyllae, rhizoma homalomenae, rhizoma arisaematis, Siegesbeckiae herba, fructus Chaenomelis, Lumbricus, radix Angelicae Pubescentis, radix Dipsaci.
The components are mixed according to the parts by weight:
and (4) tank A:
Figure BDA0002645537540000031
and (4) tank B:
Figure BDA0002645537540000041
the main components have the following functions in the system:
kunlun black jade powder: through scientific detection, the Kunlun Muyu powder contains more than thirty mineral substances and trace elements which are beneficial to the human body, and can permeate into cells of the human body for a long time, keep the balance of various elements in the human body and achieve the effects of removing diseases and building the body; the far infrared microwave emission can improve cell microcirculation, enhance cell activity, promote cell metabolism and promote absorption of medicinal components by cells.
Radix angelicae pubescentis: pungent, bitter and slightly warm. It enters liver, kidney and bladder meridians. It has the effects of wind-cold-dampness arthralgia, is pungent, bitter and dry in property, fragrant and warm in smell, good in dispelling wind-damp and relieving arthralgia, is a main drug for treating rheumatic arthralgia, and can be applied to arthralgia syndrome caused by wind-cold-dampness for any time; it enters kidney meridian and descends, so it is indicated for arthralgia due to wind-cold-dampness in lower part of waist, knee, leg and foot due to its good property, and it is indicated for arthralgia due to wind-cold-dampness.
Chinese angelica: sweet, pungent and warm, enter liver, heart and spleen meridians. It has antiinflammatory and analgesic effects, and can inhibit acute capillary permeability increase, tissue edema and chronic injury caused by various inflammatory agents, and inhibit granulation tissue hyperplasia in late stage of inflammation without affecting weight of adrenal gland and thymus, and its antiinflammatory effect is independent of pituitary-adrenal gland system. The water extract of angelica shows analgesic effect on writhing reaction caused by intraperitoneal injection of acetic acid, and the analgesic effect strength is 1.7 times of that of sodium acetylsalicylate.
Asarum: pungent and warm. It enters heart, lung and kidney meridians. Relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, dredging orifices, warming lung, and eliminating phlegm. Can be used for treating common cold due to wind-cold, headache, toothache, nasal obstruction, nasal discharge, allergic rhinitis, nasosinusitis, rheumatic arthralgia, phlegm and fluid retention, and cough and asthma.
Achyranthes bidentata: ganmaosuan, cool, enter heart, liver and large intestine meridians. Promoting blood circulation, removing blood stasis, eliminating dampness, promoting urination, and relieving inflammation and pain.
Rhizoma atractylodis: bran rhizoma atractylodis, pungent and bitter with warm nature. It enters spleen, stomach and liver meridians. Dry dampness and invigorate spleen, dispel wind and cold, improve vision. Can be used for treating abdominal distention, diarrhea, edema, rheumatalgia, and wind-cold type common cold.
Stiff silkworm: is a common traditional Chinese medicine, has the efficacies of dispelling wind, relieving spasm, reducing phlegm and resolving masses, and is clinically used for treating tangible masses, such as nodules, sore throat, scrofula, urticaria and the like, and the effect of dredging and dispersing the masses is achieved.
Myrrh: bitter and mild in taste, non-toxic, entering liver, spleen, heart and kidney meridians. Can be used for treating blood stasis and pain in chest and abdomen, dysmenorrhea, amenorrhea, abdominal mass, traumatic injury, carbuncle, skin ulcer, intestinal carbuncle, conjunctival congestion, and swelling and pain; has effects in promoting blood circulation, relieving pain, eliminating swelling, and promoting granulation; blood-activating and stasis-resolving herbs.
Calcining Pyritum: when used together, Ru Xiang can promote blood circulation and dissipate blood stasis, and relieve swelling and pain, and can be used for treating blood stasis and swelling pain due to traumatic injury.
Large-leaved gentian: pungent, bitter and mild. It enters stomach, liver and gallbladder meridians. It is mainly used for dispelling wind-damp, clearing damp-heat and stopping arthralgia.
Obscured homalomena rhizome: being pungent in property and warm in nature, it enters liver, kidney and stomach meridians. Has effects in dispelling pathogenic wind and dampness, relaxing muscles and tendons, activating collateral flow, relieving pain, and relieving swelling. It can be used for treating rheumatalgia, soreness of limbs, flaccidity of bones and muscles, traumatic injury, gastralgia, superficial infection, sore, and swelling.
Radix aconiti: pungent, bitter and hot in flavor, enter heart, liver, kidney and spleen meridians. It is used for treating arthralgia due to wind-cold-dampness, arthralgia, psychroalgia of heart and abdomen, and cold hernia. Can be used for treating arthralgia due to wind-cold-dampness and arthralgia.
Kusnezoff monkshood root: pungent and bitter in flavor and warm in nature, enter heart, liver, kidney and spleen meridians, dispel wind and dampness, warm meridians and relieve pain.
Licorice root: the famous Chinese medicine ceramic carries a landscape which is given as follows: for the old, Licorice is also called as the beauty. Licorice root, radix Glycyrrhizae harmonizes with other herbs to make it dispute, it is known as "Shi Fang Ji Cao" . Licorice, sweet in taste, has the effects of invigorating spleen, benefiting qi, moistening lung, relieving cough, relieving spasm and pain, can harmonize the medicines and alleviate the side effects of the violent medicines, and is widely used in clinical formulas.
A preparation method of a targeted moxibustion composition for treating rheumatoid arthritis comprises the following steps:
s01: baking with slow fire: weighing the components of the composition according to the weight part ratio, cleaning, adding auxiliary materials, stirring uniformly, adding into a container fired by adding clay, medical stone powder and jasper powder, sealing with yellow mud, and baking in a baking room at 35-65 ℃;
s02: nano-crushing: adding high-boron deuterium-depleted water, and micronizing at 25 deg.C to obtain suspension containing Chinese medicinal particles with nanometer particle size;
s03: and (3) sterilization and filling: short-time microwave sterilization, high-boron deuterium-depleted water dilution, pressurization filling and spray preparation.
S01 the adjuvants include one or more of Mel, yellow wine, testa Tritici, salt, and vinegar.
The traditional Chinese medicine components are baked by slow fire to increase the drug effect, and then are subjected to an ultramicro nano-pulverization technology, a high-speed air vortex is utilized to form an air knife, substances are subjected to ultramicro-granulation at a low temperature below 25 ℃, the original molecular structure of the substances is not damaged, the effect of the substances is retained to the greatest extent, the obtained traditional Chinese medicine particles are nano-sized and can be completely suspended in spray liquid, the diameter of pores is about 20-50 microns, the nano-sized traditional Chinese medicine particles can be directly absorbed through the skin, the permeability is good, and the problem that the common traditional Chinese medicine components are large in particle size and are not easy to absorb is solved. The obtained nanoscale Kunlun Muyu powder can effectively improve cell microcirculation, promote metabolism, promote absorption of cells to other traditional Chinese medicine components, directly target the pain part, and radically solve the problem of rheumatoid arthritis.
The high-boron deuterium-depleted water is adopted for dilution, researches show that the deuterium-depleted water can promote the activity of enzymes in the body, enhance the immunity of the body, effectively remove acidic waste in blood, improve the internal environment, enhance the cell activity, promote the cell metabolism and promote the absorption of nutrient substances, meanwhile, boron ions have the bacteriostatic effect, the boron ions can effectively enhance the drug effect when being used as a diluent of the moxibustion spraying composition, and the high-boron deuterium-depleted water is used for dilution and is beneficial to filling and spraying.
A targeted spray moxibustion composition for treating rheumatic arthritis is prepared by spraying pot A on Shenshu, Zhongwan and Shenque acupoints, alternately performing moxibustion by sparrow pecking and mild moxibustion for 10-30 min, and spraying pot B on the pain area for 10-30 min.
Shenshu points: kidneys are the innate root, store essence, govern bones, strengthen sense organs and have the function of strengthening adrenal glands. Moxibustion for treating the acupoints has therapeutic effects on nephropathy, osteopathia, endocrine diseases, immune system diseases and the like, and is a necessary choice for physiotherapy for treating rheumatism.
Zhongwan acupoint: the spleen and stomach are involved in the coordination of the stomach meridian. The transportation and transformation not only refers to the transportation and application of the food essence, but also includes the absorption and removal of pathological substances in the body. If the area is frequently moxibustion, the absorption and digestion functions of people are vigorous, the metabolism capability is improved, and the pathological tissues are rapidly repaired.
The Shenque point: it is the Shenqi point and the root of the disease. The acupuncture points are treated by moxibustion, have the functions of promoting and regulating the functions of internal organs, and are indispensable to treat diseases such as endocrine system, autoimmune system, deficiency, weakness and the like.
The nanometer Kunlun jasper powder in the tank A acts on the acupuncture points in a transdermal manner, so that microcirculation can be improved, cell activity can be enhanced, cell metabolism can be promoted, and absorption of cells to other traditional Chinese medicine components can be promoted, so that the active ingredients of the traditional Chinese medicine in the tank B can be effectively exerted, absorbed in a transdermal manner and directly acted on pain parts in a targeted manner; after the two times of spraying, alternate moxibustion treatment is carried out by adopting sparrow pecking moxibustion and mild moxibustion, so that the effective components of the medicine can quickly permeate to the action part, the medicine effect is enhanced, and the effect is better.
Example 1
A targeted spray moxibustion composition for treating rheumatic arthritis comprises jar A and jar B, wherein jar A comprises Kunlun Muyu powder, radix Angelicae Pubescentis, radix Notoginseng, radix Angelicae sinensis, flos Carthami, ramulus Cinnamomi, radix Clematidis, herba Taxilli, cortex Eucommiae, radix Angelicae Dahuricae, herba asari, radix Paeoniae alba, and radix astragali, jar B comprises ramulus Cinnamomi, Eupolyphaga Seu Steleophaga, radix Cyathulae, radix Achyranthis bidentatae, rhizoma Atractylodis, herba Ephedrae, Bombyx Batryticatus, Olibanum, Myrrha, Pyritum preparata, radix Angelicae sinensis, flos Carthami, rhizoma Ligustici Chuanxiong, cortex Schizophragmatis Integrifolii Radicis, rhizoma Notopterygii, rhizoma Zingiberis, radix Stephaniae Tetrandrae, radix Clematidis, fructus Lycii, cortex Eucommiae, radix Gentianae Macrophyllae, rhizoma homalomenae, rhizoma arisaematis, Siegesbeckiae herba, fructus Chaenomelis, Lumbricus, radix Angelicae Pubescentis, radix Dipsaci.
The components are mixed according to the parts by weight:
and (4) tank A:
Figure BDA0002645537540000071
and (4) tank B:
Figure BDA0002645537540000072
the composition is prepared by adopting the following steps:
s01: baking with slow fire: weighing the components of the composition according to the weight part ratio, cleaning, adding auxiliary materials, stirring uniformly, adding into a container fired by adding clay, medical stone powder and jasper powder, sealing with yellow mud, and baking in a baking room at 35-65 ℃;
s02: nano-crushing: adding high-boron deuterium-depleted water, and micronizing at 25 deg.C to obtain suspension containing Chinese medicinal particles with nanometer particle size;
s03: and (3) sterilization and filling: short-time microwave sterilization, high-boron deuterium-depleted water dilution, pressurization filling and spray preparation.
S01 the adjuvants include one or more of Mel, yellow wine, testa Tritici, salt, and vinegar.
The application method of the spray moxibustion composition comprises the steps of firstly spraying the pot A to act on Shenshu, Zhongwan and Shenque acupoints, carrying out moxibustion by adopting sparrow pecking moxibustion and mild moxibustion alternately, treating each acupoint for 10-30 minutes, and then uniformly spraying the pot B on the pain part for 10-30 minutes.
Example 2
A targeted spray moxibustion composition for treating rheumatic arthritis comprises jar A and jar B, wherein jar A comprises Kunlun Muyu powder, radix Angelicae Pubescentis, radix Notoginseng, radix Angelicae sinensis, flos Carthami, ramulus Cinnamomi, radix Clematidis, herba Taxilli, cortex Eucommiae, radix Angelicae Dahuricae, herba asari, radix Paeoniae alba, and radix astragali, jar B comprises ramulus Cinnamomi, Eupolyphaga Seu Steleophaga, radix Cyathulae, radix Achyranthis bidentatae, rhizoma Atractylodis, herba Ephedrae, Bombyx Batryticatus, Olibanum, Myrrha, Pyritum preparata, radix Angelicae sinensis, flos Carthami, rhizoma Ligustici Chuanxiong, cortex Schizophragmatis Integrifolii Radicis, rhizoma Notopterygii, rhizoma Zingiberis, radix Stephaniae Tetrandrae, radix Clematidis, fructus Lycii, cortex Eucommiae, radix Gentianae Macrophyllae, rhizoma homalomenae, rhizoma arisaematis, Siegesbeckiae herba, fructus Chaenomelis, Lumbricus, radix Angelicae Pubescentis, radix Dipsaci.
The components are mixed according to the parts by weight:
and (4) tank A:
Figure BDA0002645537540000081
and (4) tank B:
Figure BDA0002645537540000082
Figure BDA0002645537540000091
the preparation and use methods are the same as above.
Example 3
A targeted spray moxibustion composition for treating rheumatic arthritis comprises jar A and jar B, wherein jar A comprises Kunlun Muyu powder, radix Angelicae Pubescentis, radix Notoginseng, radix Angelicae sinensis, flos Carthami, ramulus Cinnamomi, radix Clematidis, herba Taxilli, cortex Eucommiae, radix Angelicae Dahuricae, herba asari, radix Paeoniae alba, and radix astragali, jar B comprises ramulus Cinnamomi, Eupolyphaga Seu Steleophaga, radix Cyathulae, radix Achyranthis bidentatae, rhizoma Atractylodis, herba Ephedrae, Bombyx Batryticatus, Olibanum, Myrrha, Pyritum preparata, radix Angelicae sinensis, flos Carthami, rhizoma Ligustici Chuanxiong, cortex Schizophragmatis Integrifolii Radicis, rhizoma Notopterygii, rhizoma Zingiberis, radix Stephaniae Tetrandrae, radix Clematidis, fructus Lycii, cortex Eucommiae, radix Gentianae Macrophyllae, rhizoma homalomenae, rhizoma arisaematis, Siegesbeckiae herba, fructus Chaenomelis, Lumbricus, radix Angelicae Pubescentis, radix Dipsaci.
The components are mixed according to the parts by weight:
Figure BDA0002645537540000092
and (4) tank B:
Figure BDA0002645537540000093
Figure BDA0002645537540000101
the preparation and use methods are the same as above.
Comparative example 1
Tank a contained no kunlun topaz powder, and the rest was the same as in example 2.
Comparative example 2
The composition in the example 2 is directly and commonly ground without being baked by slow fire, sieved by a 100-mesh sieve, sterilized and filled, and the rest are the same.
Comparative example 3
The composition of example 2 was applied to the human body in both tank A and tank B, and the rest were the same.
The compositions for moxibustion according to the invention are further described below by means of animal tests and tests of clinical effectiveness.
First, animal experiment
(one) detumescence Effect test
1. Preparation of mouse pinna swelling model: 70 adult mice weighing 200-300 g were randomly divided into seven groups, each group corresponding to the test of the above-mentioned spray moxibustion composition prepared in examples 1-3 and the spray moxibustion composition prepared in comparative examples 1-3, and the remaining group was a control group. A microinjector was used to drop 0.02mL of xylene into the right ear of the mouse and the xylene was allowed to saturate both sides of the mouse ear, and the left ear was used as a control. Except for a control group, the other groups are treated by adopting corresponding moxibustion spraying compositions, the mouse is killed by pulling the neck after 2h, two ears are cut along the base line of the auricle, ear sheets are punched at the symmetrical parts of the left ear and the right ear by adopting a 6 mm-diameter puncher, the mass of each mouse ear is weighed by using a precise electronic balance, and the swelling rate and the inhibition rate of the mouse ear are calculated by the following calculation formula:
swelling rate ═ mass of right ear-mass of left ear)/mass of left ear × 100%
Inhibition rate ═ degree of control group auricle swelling-degree of experimental group auricle swelling)/degree of control group auricle swelling × 100%
2. Statistics of results
Group of n Degree of auricle swelling (mg) Inhibition ratio (%)
Control group 10 32.79±10.11 ——
Example 1 10 12.08±8.53 63.16
Example 2 10 8.36±6.98 74.50
Example 3 10 10.28±6.37 68.65
Comparative example 1 10 20.37±6.42 37.88
Comparative example 2 10 22.38±11.58 31.74
Comparative example 3 10 18.66±15.71 43.09
The higher the inhibition value, the more effective the elimination effect on the swelling of mouse auricle. As can be seen from the above table, the moxibustion spray compositions prepared in the examples have higher inhibition rate and more obvious detumescence effect compared with the comparative examples.
(II) analgesic Activity test
1. Mouse acetic acid writhing experiment: 70 adult mice weighing 200-300 g were randomly divided into seven groups, each group corresponding to the test of the above-mentioned spray moxibustion composition prepared in examples 1-3 and the spray moxibustion composition prepared in comparative examples 1-3, and the remaining group was a control group. Injecting 0.7% HAC normal saline 0.2mL into abdominal cavity of each mouse, treating the rest groups except the control group with corresponding moxibustion spraying composition, recording the times of mouse writhing reaction within 20min, and calculating the percentage of analgesic inhibition, wherein the calculation formula is as follows:
percent (%) pain (number of writhing response in control group-number of writhing response in experimental group)/number of writhing response in control group × 100%
2. Statistics of results
Group of n Number of wriggling reactions Inhibition ratio (%)
Control group 10 60.3±6.3 ——
Example 1 10 20.6±8.4 65.8
Example 2 10 16.5±7.9 72.6
Example 3 10 18.9±6.7 68.7
Comparative example 1 10 40.7±6.2 32.5
Comparative example 2 10 42.8±10.5 29.0
Comparative example 3 10 38.6±11.1 36.0
The higher the percentage analgesic value, the more obvious the analgesic effect. As can be seen from the above table, the moxibustion spray compositions prepared in the examples have higher inhibition rate and better analgesic effect than the comparative examples.
Second, clinical efficacy testing
The effect test was carried out on the above-mentioned spray moxibustion compositions prepared in examples 1 to 3 and the spray moxibustion compositions prepared in comparative examples 1 to 3.
300 patients with rheumatoid arthritis were randomly assigned into six groups, and the moxibustion composition prepared in examples 1 to 3 and the moxibustion composition prepared in comparative examples 1 to 3 were used 2 times a day for 1 month continuously, and the statistical results of the therapeutic effects were shown in the following table.
The judgment standard of the curative effect condition is as follows:
obvious effect-ache and red swelling are obviously relieved or healed, and the value of O resistance is greatly reduced or recovered to be normal;
effective-ache and red swelling are relieved, and the anti-O value is reduced;
ineffectiveness, pain, redness and swelling did not change significantly or tended to worsen, and the anti "O" value did not decrease or tended to increase.
Group of n Show effect Is effective Invalidation Total effective rate
Example 1 50 40 6 4 92％
Example 2 50 45 5 0 100％
Example 3 50 42 6 2 96％
Comparative example 1 50 26 8 16 68％
Comparative example 2 50 15 10 25 50％
Comparative example 3 50 28 9 13 74％
As can be seen from the above table, compared with the comparative examples, the effective rates of the moxibustion spray compositions prepared in the examples are higher in terms of rheumatoid arthritis, all of which are above 90%, and no adverse reaction occurs in the test period of the moxibustion spray composition, which indicates that the moxibustion spray composition has a significant effect in terms of treating rheumatoid arthritis.
Typical cases are:
1. in the case of a certain Liangqi, male, 55 years old, more than three years old of joint and muscle wandering ache and red swelling, inconvenient movement and serious influence on daily life, the spraying moxibustion composition of the invention is firstly sprayed on the A pot to act on Shenshu, Zhongwan and Shenque acupoints, sparrow pecking moxibustion and mild moxibustion are alternately adopted for moxibustion, each acupoint is used for moxibustion for 10-30 minutes, and then the B pot is uniformly sprayed on the pain part for moxibustion for 10-30 minutes. After continuous use for 2 months, the symptoms are improved, and after continuous use for 4 months, the patient can move freely without relapse in follow-up visit at later stage.
2. A certain bear, a woman in the age of 60, swollen double knee joints, deformed bones and pain which are severe when encountering cold, test resistance of a hospital is 800 units, the spraying moxibustion composition is firstly sprayed into the A pot to act on Shenshu, Zhongwan and Shenque acupoints, sparrow pecking moxibustion and mild moxibustion are alternately used for moxibustion, each acupoint is used for moxibustion for 10-30 minutes, and then the B pot is uniformly sprayed on the pain part for moxibustion for 10-30 minutes. After 1 month of use, the pain is relieved, after 3 months of continuous use, the pain is cured, the anti-O is reduced to 400 units, and the disease does not relapse after follow-up at the later stage.
3. The symptoms of a male, 51 years old are manifested as pain in joints of various parts of the whole body, especially the deformity of joints of both hands is accompanied by numbness and stiffness, oral administration of the anti-inflammatory analgesic drug has no fruits, the spray moxibustion composition disclosed by the invention is firstly sprayed on the A pot to act on Shenshu, Zhongwan and Shenque acupoints, sparrow pecking moxibustion and mild moxibustion are alternately used for moxibustion, each acupoint is used for moxibustion for 10-30 minutes, and then the B pot is uniformly sprayed on the pain part for moxibustion for 10-30 minutes. After 2 months of continuous use, the joint pain is relieved, the symptoms are obviously improved, after 3 months of continuous use, the joint pain basically returns to normal, and the disease does not relapse after follow-up visit in the later period.
Although the present invention has been described in detail with reference to the above description, the design concept of the present invention is not limited thereto. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. The present invention is not limited to the above embodiments, and various modifications and changes may be made without departing from the spirit and scope of the present invention.

Claims (5)

1. A targeted moxibustion composition for treating rheumatoid arthritis is characterized in that: comprises a pot A and a pot B, wherein the pot A comprises Kunlun Muyu powder, pubescent angelica root, notoginseng, angelica, safflower, cassia twig, clematis root, Loranthus mulberry mistletoe, eucommia bark, dahurian angelica root, asarum, white peony root and astragalus root, the pot B comprises cassia twig, dried body of ground beetle, cyathula root, achyranthes root, atractylodes rhizome, ephedra, batryticated silkworm, frankincense, myrrh, calcined pyrite, angelica, safflower, Ligusticum wallichii, rhizome of rehmannia, notopterygium root, dried ginger, tetrandra root, clematis root, medlar, eucommia bark, large-leaf gentian root, homalomena rhizome, arisaema tuber, siegesbeckia herb, pawpaw, earthworm, pubescent angelica root, dipsacus root.
2. The targeted moxibustion composition for treating rheumatoid arthritis according to claim 1, wherein the composition comprises: the components are mixed according to the parts by weight:
and (4) tank A:
Figure FDA0002645537530000011
and (4) tank B:
Figure FDA0002645537530000012
Figure FDA0002645537530000021
3. the preparation method of the targeted moxibustion composition for treating rheumatoid arthritis according to any one of claims 1 to 2, which is characterized by comprising the following steps: the method comprises the following steps:
s01: baking with slow fire: weighing the components of the composition according to the weight part ratio, cleaning, adding auxiliary materials, stirring uniformly, adding into a container fired by adding clay, medical stone powder and jasper powder, sealing with yellow mud, and baking in a baking room at 35-65 ℃;
s02: nano-crushing: adding high-boron deuterium-depleted water, and micronizing at 25 deg.C to obtain suspension containing Chinese medicinal particles with nanometer particle size;
s03: and (3) sterilization and filling: short-time microwave sterilization, high-boron deuterium-depleted water dilution, pressurization filling and spray preparation.
4. The preparation method of the targeted moxibustion composition for treating rheumatoid arthritis according to claim 3, wherein the preparation method comprises the following steps: s01 the adjuvants include one or more of Mel, yellow wine, testa Tritici, salt, and vinegar.
5. The use method of the targeted moxibustion composition for treating rheumatoid arthritis according to any one of claims 1 to 2, wherein the composition comprises the following components: firstly spraying the pot A to act on Shenshu, Zhongwan and Shenque acupoints, performing moxibustion alternately by sparrow pecking moxibustion and mild moxibustion for 10-30 minutes, and then uniformly spraying the pot B on the pain part for 10-30 minutes.
CN202010853302.9A 2020-08-23 2020-08-23 Targeted spray moxibustion composition for treating rheumatic arthritis and preparation and use methods thereof Pending CN111840383A (en)

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CN111840318A (en) * 2020-08-23 2020-10-30 刘东泰 Targeted moxibustion composition for treating male sexual dysfunction and preparation and use methods thereof
CN111840317A (en) * 2020-08-23 2020-10-30 刘东泰 Targeted spray moxibustion composition for treating hypertension and preparation and use methods thereof
CN111939173A (en) * 2020-08-23 2020-11-17 刘东泰 Targeted spray moxibustion composition for treating skin diseases and preparation and use methods thereof

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CN111840318A (en) * 2020-08-23 2020-10-30 刘东泰 Targeted moxibustion composition for treating male sexual dysfunction and preparation and use methods thereof
CN111905088A (en) * 2020-08-23 2020-11-10 刘东泰 Targeted spray moxibustion composition for treating alopecia and preparation and use methods thereof

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CN101306003A (en) * 2008-04-15 2008-11-19 天津市尖峰天然产物研究开发有限公司 Use of cyaniding 3-0 glucoside in preparing medicament or food for preventing and curing atrophic arthritis
CN111840318A (en) * 2020-08-23 2020-10-30 刘东泰 Targeted moxibustion composition for treating male sexual dysfunction and preparation and use methods thereof
CN111905088A (en) * 2020-08-23 2020-11-10 刘东泰 Targeted spray moxibustion composition for treating alopecia and preparation and use methods thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111840318A (en) * 2020-08-23 2020-10-30 刘东泰 Targeted moxibustion composition for treating male sexual dysfunction and preparation and use methods thereof
CN111840317A (en) * 2020-08-23 2020-10-30 刘东泰 Targeted spray moxibustion composition for treating hypertension and preparation and use methods thereof
CN111939173A (en) * 2020-08-23 2020-11-17 刘东泰 Targeted spray moxibustion composition for treating skin diseases and preparation and use methods thereof

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