CN114681551B - Traditional Chinese medicine composition for treating arthralgia and myalgia, preparation and application thereof - Google Patents

Traditional Chinese medicine composition for treating arthralgia and myalgia, preparation and application thereof Download PDF

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CN114681551B
CN114681551B CN202011594344.1A CN202011594344A CN114681551B CN 114681551 B CN114681551 B CN 114681551B CN 202011594344 A CN202011594344 A CN 202011594344A CN 114681551 B CN114681551 B CN 114681551B
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rhizoma
radix
weight
chinese medicine
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CN114681551A (en
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王卫平
李梦玲
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Li Mengling
Wang Weiping
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Abstract

The invention relates to a traditional Chinese medicine composition for treating arthralgia and myalgia, a preparation and application thereof, wherein the traditional Chinese medicine composition comprises the following raw material components: rhizoma homalomenae, radix Tripterygii Wilfordii, radix Angelicae Pubescentis, rhizoma Et radix Notopterygii, rhizoma corydalis, flos Carthami, herba speranskiae tuberculatae, rhizoma Drynariae, fructus Lipuidambaris, herba asari, rhizoma Cibotii, rhizoma Dioscoreae Septemlobae, rhizoma Chuanxiong, radix Angelicae sinensis, caulis Spatholobi, herba Lycopodii, ramulus Mori, radix Angelicae Dahuricae, semen Persicae, radix Dipsaci, radix Gentianae Macrophyllae, cortex Eucommiae, radix Paeoniae Rubra, folium Artemisiae Argyi, radix Achyranthis bidentatae, herba Taxilli, radix aucklandiae, lignum Pini nodi, fructus Chaenomelis, radix Glycyrrhizae, myrrha, olibanum, scorpio, borneolum Syntheticum, pheretima, zaocys, agkistrodon, eupolyphaga Seu Steleophaga, hirudo, scorpio. The traditional Chinese medicine composition is prepared by combining multiple medicinal materials according to the external treatment principle of the traditional Chinese medicine for promoting blood circulation to remove blood stasis, promoting qi circulation to stop pain and clearing and activating the channels and collaterals, can effectively improve the local qi and blood circulation of the bone joint disease symptom part, has the characteristics of strong permeability, quick response, high cure rate, convenient use and difficult recurrence, and is suitable for relieving various pains caused by various reasons of wind-cold-dampness arthralgia.

Description

Traditional Chinese medicine composition for treating arthralgia and myalgia, preparation and application thereof
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating arthralgia and myalgia, a preparation and application thereof.
Background
Osteoarthropathy such as cervical spondylosis, lumbar spondylosis, scapulohumeral periarthritis, hyperosteogeny, degenerative arthritis, bursitis, synovitis, rheumatic arthritis, rheumatoid arthritis, femur head necrosis, etc. Pain associated with bone joint disease is a common pain symptom in daily life caused by various internal and external factors. At present, the method for treating the bone joint diseases and the medicines for relieving the pain are more and have certain effects, but the problems of slow effect, unobvious treatment effect, easy recurrence after healing and difficult radical cure exist.
Disclosure of Invention
The first aim of the invention is to provide a traditional Chinese medicine composition for treating arthralgia and myalgia, which is prepared by combining multiple medicinal materials according to the principle of external treatment of meridian along the meridian, wherein the traditional Chinese medicine composition has the advantages of promoting blood circulation, removing blood stasis, promoting qi circulation, relieving pain, clearing and activating the channels and collaterals, can effectively improve local qi and blood circulation of the bone joint disease symptom part, has the characteristics of strong permeability, quick response, high cure rate and convenient use, and is not easy to relapse, and is suitable for relieving various pains caused by various reasons of wind-cold-dampness arthralgia.
The second aim of the invention is to provide a traditional Chinese medicine preparation containing the traditional Chinese medicine composition.
The third object of the invention is to provide the application of the traditional Chinese medicine composition, in particular to the application in preparing medicines for treating bone joint diseases and traumatic injuries.
In order to achieve the above object, the present invention adopts the following technical scheme:
a Chinese medicinal composition for treating arthralgia and myalgia comprises the following raw materials:
2-8 parts of obscured homalomena rhizome, 2-8 parts of tripterygium wilfordii, 1-5 parts of radix angelicae pubescentis, 1-5 parts of notopterygium root, 1-5 parts of rhizoma corydalis, 1-5 parts of safflower, 1-5 parts of garden balsam stem, 0.5-5 parts of drynaria rhizome, 0.5-5 parts of fructus liquidambaris, 0.5-5 parts of asarum, 0.5-5 parts of rhizoma cibotii, 0.5-5 parts of rhizoma dioscoreae, 0.5-5 parts of ligusticum wallichii, 0.5-5 parts of angelica sinensis, 0.5-5 parts of spatholobus stem, 0.5-5 parts of lycopodium clavatum, 0.3-3 parts of mulberry twig, 0.3-3 parts of radix angelicae, 0.3-3 parts of peach seed, 0.3-3 parts of radix dipsaci, 0.3-3 parts of large-leaved gentian root, 0.3-3 parts of large-leaved gentian 0.3-3 parts of eucommia ulmoides, 0.3-3 parts of red paeony root, 0.3-3 parts of mugwort leaf, 0.3-3 parts of achyranthes root, 0.3-3 parts of Chinese taxillus twig, 0.3-3 parts of costustoot, 0.3-3 parts of pine node, 0.3-3 parts of papaya, 0.3-3 parts of liquorice, 0.5-5 parts of myrrh, 0.5-5 parts of frankincense, 0.5-5 parts of blood scorpion, 0.5-5 parts of borneol, 0.2-2 parts of earthworm, 0.2-2 parts of black-tail snake, 0.1-1 parts of long-noded pit viper, 0.1-1 parts of ground beetle, 0.1-1 part of leech, 0.1-1 part of scorpion and 0.1-1 part of centipede.
Preferably, the raw material components of the traditional Chinese medicine composition for treating arthralgia and myalgia comprise:
3-5 parts of obscured homalomena rhizome, 3-5 parts of tripterygium wilfordii, 2-4 parts of radix angelicae pubescentis, 2-4 parts of notopterygium root, 2-4 parts of rhizoma corydalis, 2-4 parts of safflower, 2-4 parts of garden balsam stem, 1-3 parts of rhizoma drynariae, 1-3 parts of fructus liquidambaris, 1-3 parts of asarum, 1-3 parts of rhizoma cibotii, 1-3 parts of rhizoma dioscoreae, 1-3 parts of ligusticum wallichii, 1-3 parts of angelica sinensis, 1-3 parts of spatholobus stem, 1-3 parts of lycopodium clavatum, 0.5-1.5 parts of mulberry twig, 0.5-1.5 parts of angelica dahurica, 0.5-1.5 parts of peach seed, 0.5-1.5 parts of teasel root, 0.5-1.5 parts of large-leaved gentian, 1.5 parts of rhizoma dioscoreae 0.5 to 1.5 weight parts of eucommia bark, 0.5 to 1.5 weight parts of red paeony root, 0.5 to 1.5 weight parts of mugwort leaf, 0.5 to 1.5 weight parts of achyranthes root, 0.5 to 1.5 weight parts of Chinese taxillus twig, 0.5 to 1.5 weight parts of costustoot, 0.5 to 1.5 weight parts of pine node, 0.5 to 1.5 weight parts of papaya, 0.5 to 1.5 weight parts of liquorice, 1 to 3 weight parts of myrrh, 1 to 3 weight parts of frankincense, 1 to 3 weight parts of blood scorpion, 1 to 3 weight parts of borneol, 0.5 to 1.5 weight parts of earthworm, 0.5 to 1.5 weight parts of black-tail snake, 0.3 to 0.8 weight parts of long-noded pit viper, 0.3 to 0.8 weight parts of ground beetle, 0.3 to 0.8 weight parts of leech, 0.3 to 0.8 weight parts of scorpion and 0.3 to 0.8 weight part of centipede.
Preferably, the raw material components of the traditional Chinese medicine composition for treating arthralgia and myalgia comprise:
4 parts of obscured homalomena rhizome, 4 parts of tripterygium wilfordii, 3 parts of radix angelicae pubescentis, 3 parts of notopterygium root, 3 parts of rhizoma corydalis, 3 parts of safflower, 3 parts of garden balsam stem, 2 parts of rhizoma drynariae, 2 parts of fructus liquidambaris, 2 parts of asarum herb, 2 parts of rhizoma cibotii, 2 parts of rhizoma dioscoreae, 2 parts of rhizoma ligustici wallichii, 2 parts of angelica sinensis, 2 parts of caulis spatholobi, 2 parts of lycopodium clavatum, 1 part of ramulus mori, 1 part of radix angelicae, 1 part of peach kernel, 1 part of radix dipsaci, 1 part of gentianae macrophylla, 1 part of eucommia bark, 1 part of radix paeoniae rubra, 1 part of folium artemisiae argyi, 1 part of achyranthes bidentata, 1 part of herba taxilli, 1 part of elecampane, 1 part of radix aucklandiae, 1 part of pine, 1 part of papaya, 1 part of liquorice, 2 parts of myrrh, 2 parts of frankincense, 2 parts of blood scorpion, 2 parts of borneol, 1 part of earthworm, 1 part of black-tail, 0.5 part of snake, 0.5 part of ground beetle, 0.5 part of white leech, 0.5 part of centipede and 0.5 part of centipede.
The traditional Chinese medicine composition for treating arthralgia and myalgia disclosed by the invention has the effects of dispelling wind and removing dampness, relieving swelling and pain and strengthening tendons and bones; tripterygium wilfordii wind-dispelling dampness-removing, vein relaxing pain-relieving, heat-clearing swelling-reducing, detoxifying and insect-killing, both of which are monarch drugs. Radix Angelicae Pubescentis, notopterygii rhizoma, herba asari, fructus Lipuidambaris, rhizoma corydalis, carthami flos, herba Speranskiae Tuberculatae, rhizoma Dioscoreae Septemlobae, rhizoma Ligustici Chuanxiong, herba Lycopodii, lignum Pini nodi, radix Angelicae Dahuricae, radix aucklandiae together with strengthening monarch drug effects of dispelling pathogenic wind, removing dampness, dredging collaterals and relieving pain, olibanum, myrrha, sanguis Draxonis, borneolum Syntheticum, semen Persicae for removing blood stasis, dredging channels, detumescence and promoting granulation; zaocys, agkistrodon, eupolyphaga Seu Steleophaga, hirudo, scolopendra, scorpio, lumbricus for dispelling pathogenic wind, calming endogenous wind, dispelling pathogenic wind, relieving spasm, removing scurrying, relieving pain, penetrating tendons and bones, and relieving convulsion, and all the herbs are mutually combined and mutually supplemented to be ministerial drugs. Teasel root, eucommia bark, mistletoe, drynaria rhizome, east Asian tree fern rhizome and papaya have the functions of nourishing liver and kidney and strengthening tendons and bones; chinese angelica, red paeony root, suberect spatholobus stem and twotooth achyranthes root are used as adjuvant drugs for nourishing blood and activating blood. Ramulus Mori, radix Gentianae Marcrophyllae, glycyrrhrizae radix, radix Angelicae sinensis, and radix Glycyrrhizae are used as guiding drugs for relieving swelling and benefiting joint. The medicines are compatible, and have the effects of dispelling wind and removing dampness, dredging collaterals and relieving pain, activating blood and dissolving stasis, detumescence and promoting granulation, calming endogenous wind and relieving spasm, strengthening tendons and tonifying kidney.
The traditional Chinese medicine composition for treating arthralgia and myalgia has large compatibility because of the cold and toxic nature of tripterygium wilfordii, and is effective for reducing toxicity and enhancing efficiency. The auxiliary medicines for nourishing and supplementing multiple auxiliary medicines are used for restricting the repair of the severe drug effect. The medicines are used for harmonizing the guiding and penetrating end points of the medicines, and Rong Jingu is advantageous for the joints to combine flexibly.
In order to facilitate understanding of the present invention, the crude drugs and the efficacy of the present invention will now be further described.
Obscured homalomena rhizome, rhizoma homalomenae, bitter and pungent in taste and warm in nature. Enter liver meridian and kidney meridian. Dispelling wind-dampness and strengthening tendons and bones. It is indicated for wind-cold-dampness arthralgia, cold pain in waist and knee, contracture and numbness of lower limbs.
Lei Gong Teng is bitter and pungent in flavor and cool in nature. It enters liver and kidney meridians. Dispelling wind and removing dampness, promoting blood circulation and removing obstruction in collaterals, relieving swelling and pain, killing parasites and detoxicating. Is used for treating rheumatoid and rheumatic arthritis, glomerulonephritis, nephrotic syndrome, intractable headache, body pain, lupus erythematosus, behcet's disease, psoriasis, leprosy, eczema, scabies, tinea, and venomous snake bite.
Du Huo is pungent and bitter in flavor and slightly warm in nature. Enter kidney and bladder meridians. Dispelling wind and removing dampness, and relieving arthralgia and pain. Can be used for treating arthralgia due to wind-cold-dampness, lumbago, gonalgia, headache due to wind-damp evil, and headache due to wind-cold-dampness.
Qiang Huo is pungent and bitter in flavor and warm in nature. Enter the urinary bladder and kidney meridians. Relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, eliminating dampness, and relieving pain. Wind-cold common cold, arthralgia due to wind-cold-dampness, strong and acute muscles and tendons, bone and joint pain, edema due to wind-water, carbuncle, and sore.
Yan Hu is pungent, bitter and warm in nature. Enter liver and spleen meridians. Promoting blood circulation, promoting qi circulation, and relieving pain. Can be used for treating chest pain, hypochondrium pain, abdominal pain, chest pain, amenorrhea, dysmenorrhea, puerperal stagnation, and traumatic injury.
Safflower, pungent in flavor and warm in nature. It enters heart and liver meridians. Promoting blood circulation to remove blood stasis and dredging channels. Can be used for treating amenorrhea due to blood stagnation, puerperal stagnation, abdominal mass, traumatic injury, and measles.
Speranskia herb, herba speranskiae tuberculatae, pungent in flavor and warm in nature. Enter the liver and kidney meridians. Dispelling wind and removing dampness, relaxing tendons and activating blood circulation, removing blood stasis and detumescence, detoxication and relieving pain. Wind-damp arthralgia, contracture of tendons and bones, cold-dampness beriberi, lumbar sprain, paralysis, amenorrhea, eczema of scrotum, sore and furuncle.
Rhizoma Drynariae, bitter in taste and warm in nature. It enters liver and kidney meridians. Promoting blood circulation to remove blood stasis. Tonify kidney, strengthen bone, continue injury and relieve pain. For the purpose of: lumbago due to kidney deficiency, tinnitus, deafness, loose teeth, traumatic injury, sprain, and tendons and bones injury; it is used for treating alopecia areata and vitiligo.
Liu Tong is bitter in taste and neutral in nature. Liver and kidney meridians. Dispelling wind and activating collaterals, promoting diuresis and dredging channels. Can be used for treating arthralgia, numbness, spasm, edema, distention, hypogalactia, and amenorrhea.
Asarum, pungent in flavor and warm in nature. It enters heart, lung and kidney meridians. Relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, inducing resuscitation, warming lung, and resolving fluid retention. Can be used for treating common cold due to wind-cold, headache, toothache, rheumatalgia, nasosinusitis, and cough due to lung cold.
Cibotium rhizome, rhizoma Cibotii, bitter in taste, sweet in flavor and warm in nature. It enters liver and kidney meridians. Dispelling wind-damp, tonifying liver and kidney, strengthening waist and knee. Can be used for treating rheumatalgia, soreness of waist and knees, and weakness of lower limbs.
Di Xie is bitter in taste and flat in nature. Enter kidney and stomach meridians. Remove dampness and turbid pathogen, dispel wind and remove arthralgia. Can be used for treating stranguria due to plaster, turbid urine, leukorrhagia, rheumatalgia, joint disorder, and lumbago and gonalgia.
Chuan Xiong, is pungent in flavor and warm in nature. Enter liver, gallbladder and pericardium meridians. Promoting blood circulation, activating qi-flowing, dispelling pathogenic wind and relieving pain. Can be used for treating menoxenia, hypochondriac pain, thoracic obstruction, sore pain, traumatic injury, headache, and rheumatalgia.
Dang Gui is sweet and pungent in flavor and warm in nature. It enters liver, heart and spleen meridians. Replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, and loosening bowel to relieve constipation. Can be used for treating sallow complexion due to blood deficiency, dizziness, palpitation, menoxenia, amenorrhea, dysmenorrhea, abdominal pain due to deficiency-cold, rheumatalgia, traumatic injury, carbuncle, skin ulcer, and constipation due to intestinal dryness.
Spatholobus stem, caulis Spatholobi, bitter in taste, slightly sweet in flavor and warm in nature. Enter liver meridian. Promoting blood circulation, replenishing blood, relaxing tendons, and activating collaterals. It can be used for treating menoxenia, amenorrhea due to blood deficiency, rheumatalgia, and apoplexy.
Lycopodium clavatum is bitter, slightly pungent and warm in nature. Dispelling wind and removing dampness, relaxing tendons and activating collaterals. Can be used for treating joint pain and difficulty in flexing and extending.
Ramulus Mori, slightly bitter in taste and flat in nature. Enter liver meridian. Dispel wind-damp, promote articulation. Can be used for treating rheumatalgia, and soreness and numbness of shoulder and arm and joint.
Bai Zhi is pungent in flavor and warm in nature. Enter lung, spleen and stomach meridians. Relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, relieving stuffy nose, eliminating dampness, stopping leukorrhagia, relieving swelling, expelling pus, dispelling pathogenic wind, and relieving itching. Can be used for treating common cold due to wind-cold, headache, toothache, rheumatalgia, nasosinusitis, leukorrhagia, sore, carbuncle, and toxic swelling.
Peach kernel, semen Persicae, bitter in taste, sweet in flavor and neutral in nature. It enters heart, liver and large intestine meridians. Promoting blood circulation, removing blood stasis, loosening bowel to relieve constipation, relieving cough and asthma. Can be used for treating amenorrhea dysmenorrhea, abdominal mass, pulmonary abscess, acute appendicitis, traumatic injury, constipation due to intestinal dryness, cough and asthma.
Dipsaci radix, bitter, sweet and pungent in flavor and slightly warm in nature. It enters liver and kidney meridians. Liver and kidney nourishing, blood circulation promoting, and tendons and bones strengthening effects. Can be used for treating soreness of waist and knees, rheumatalgia, traumatic injury, and fracture swelling and pain.
Qin jiao is bitter and pungent in flavor and slightly cold in nature. It enters stomach, liver and gallbladder meridians. Dispelling wind-damp, relaxing muscles and tendons, expelling collateral obstruction, and clearing away deficiency-heat. Can be used for treating rheumatalgia, joint contracture, hand and foot paralysis, hectic fever due to bone steaming, and jaundice due to damp-heat.
Du Zhong is sweet and slightly pungent in flavor and warm in nature. Enter the liver and kidney meridians. Liver and kidney tonifying, tendons and bones strengthening, miscarriage preventing. For soreness and pain of waist and knees, weakness of feet and knees, dribbling urine, itching of yin, abortion, fetal movement, and hypertension.
Red peony root, radix Paeoniae Rubra, bitter in taste and slightly cold in nature. Enter liver meridian. Clear heat and cool blood, dissipate blood stasis and relieve pain. Can be used for treating heat-induced ying blood, toxic heat, speckle, hematemesis, epistaxis, conjunctival congestion, liver Yu Xie pain, amenorrhea, dysmenorrhea, abdominal pain, traumatic injury, carbuncle, swelling, and pyocutaneous disease.
Ai Ye is pungent and bitter in flavor and warm in nature. It enters liver, spleen and kidney meridians. Warming channels to stop bleeding, dispelling cold and relieving pain; for external use, it can dispel dampness and relieve itching. Can be used for treating hematemesis, epistaxis, metrorrhagia, menorrhagia, metrostaxis, lower abdomen cold pain, cold menstruation, infertility due to cold womb; it is used for treating skin pruritus. Vinegar Ai Tanwen is used for stopping bleeding due to deficiency-cold.
Achyranthes root, radix Achyranthis bidentatae, bitter, sweet, sour and neutral in nature. It enters liver and kidney meridians. Removing blood stasis, dredging channels, nourishing liver and kidney, strengthening tendons and bones, inducing diuresis, treating stranguria, and guiding blood downward. Can be used for treating amenorrhea, dysmenorrhea, soreness of waist and knees, weakness of tendons and bones, stranguria, edema, headache, dizziness, toothache, solar sore, hematemesis, and epistaxis.
Loranthus mulberry mistletoe, bitter and sweet in flavor, and flat in nature. It enters liver and kidney meridians. Dispelling wind-dampness, tonifying liver and kidney, strengthening tendons and bones, and tranquilizing the fetus. Can be used for treating rheumatalgia, soreness of waist and knees, weakness of tendons and bones, metrorrhagia, metrostaxis, blood leakage during pregnancy, fetal irritability, and dizziness.
Mu Xiang is pungent and bitter in flavor and warm in nature. It enters spleen, stomach, large intestine and gallbladder meridians. Promoting qi circulation, relieving pain, regulating middle energizer and dispersing stagnated food. Can be used for treating abdominal distention and pain, diarrhea, spleen deficiency, anorexia, hypochondriac pain, and jaundice.
Pine section, bitter taste and warm nature. It enters liver and kidney meridians. Dispelling wind and eliminating dampness, relaxing tendons and dredging collaterals, promoting blood circulation and relieving pain. Wind-cold-dampness arthralgia, wind-cold-pain in the joints, paralysis of the feet, and traumatic injury.
Papaya, acid, warm. Enter liver and spleen meridians. Relaxing tendons, activating collaterals, resolving dampness and harmonizing stomach. Can be used for treating rheumatalgia, spasm of tendons and vessels, tinea pedis, swelling and pain, vomiting and diarrhea, and tendons transfer.
Licorice root, radix Glycyrrhizae, sweet in taste and neutral in nature. It enters heart, lung, spleen and stomach meridians. Spleen invigorating, qi replenishing, heat and toxic materials clearing away, phlegm eliminating, cough relieving, pain relieving, and medicines regulating. Can be used for treating weakness of spleen and stomach, listlessness, debilitation, palpitation, short breath, cough with excessive phlegm, abdominal pain, limb spasm, carbuncle, swelling, sore and toxic materials, and relieving drug toxicity and intensity.
Myrrh is pungent and bitter in taste and neutral in nature. It enters heart, liver and spleen meridians. Removing blood stasis, relieving pain, detumescence and promoting granulation. Can be used for treating chest pain, gastralgia, dysmenorrhea, amenorrhea, puerperal stagnation, abdominal mass, abdominal pain, rheumatalgia, traumatic injury, carbuncle, swelling, and skin infection.
Boswellia is pungent and bitter in flavor and warm in nature. It enters heart, liver and spleen meridians. Promoting blood circulation, relieving pain, detumescence and promoting granulation. Can be used for treating dysmenorrhea, amenorrhea, gastralgia, rheumatalgia, traumatic injury, carbuncle, swelling and ulcer.
XueXie is sweet, salty and neutral in nature. It enters heart meridian and liver meridian. Remove blood stasis, relieve pain, stop bleeding and promote the production of body fluid. Can be used for treating traumatic injury, internal injury, blood stasis, traumatic hemorrhage, skin ulcer abscess, and chronic ulcer.
Borneol, pungent and bitter in flavor, slightly cold in nature. It enters heart, spleen and lung meridians. Inducing resuscitation and refreshing mind, and clearing heat and relieving pain. Can be used for treating fever, unconsciousness, convulsion, apoplexy, phlegm syncope, qi stagnation syncope, middle-jiao coma, chest pain, conjunctival congestion, aphtha, laryngopharynx swelling and pain, and ear canal purulence.
Lu Di is salty in taste and cold in nature. Enter liver, spleen and bladder meridians. Clear heat, calm wind, relieve dyspnea, dredge collaterals and induce diuresis. Can be used for treating infantile convulsion, tetany, cough and asthma due to lung heat, arthralgia, hemiplegia, and infantile malnutrition due to heat accumulation.
Zaocys is sweet in taste and neutral in nature. Enters the lung, spleen and liver meridians. Dispel wind-damp, unblock collaterals and stop spasm. Wind-damp arthralgia, numbness of skin, spasm of tendons and vessels, paralysis of limbs, tetanus, leprosy, rubella and mange.
Long-noded pit viper, sweet and salty in taste and warm in nature. Enter the liver and spleen meridians. Dispel wind, unblock collaterals and stop spasm. Can be used for treating rheumatism, numbness, contracture, apoplexy, hemiplegia, convulsion, tetanus, leprosy, scabies, scrofula, and malignant sore.
Eupolyphaga Seu Steleophaga is salty in taste and cold in nature. Breaking blood and removing stasis, and promoting reunion of fractured bones. Can be used for treating amenorrhea, abdominal mass, puerperal stagnation, fracture, and pain.
Leech is salty and bitter in taste and neutral in nature. Enter liver meridian. Break blood and promote menstruation, remove blood stasis and relieve symptoms. Can be used for treating amenorrhea due to blood stasis, addiction, abdominal mass, apoplexy, hemiplegia, and traumatic injury.
Scorpio, pungent in flavor and flat in nature. Is toxic. Enter liver meridian. Calm wind and stop spasm, detoxify and dissipate nodulation, dredge collaterals and relieve pain. Can be used for treating acute and chronic infantile convulsion, facial distortion, tetanus, sore, scrofula, tuberculosis, migraine, and rheumatalgia.
Scolopendra, pungent in flavor and warm in nature. Enter liver meridian. Wind-extinguishing and spasm-relieving, vein-relaxing and pain-relieving, toxin-eliminating and stagnation-dissipating. Can be used for treating internal movement of liver wind, convulsion, infantile convulsion, apoplexy, wry mouth, hemiplegia, tetanus, rheumatism, migraine, sore, scrofula, and snake and insect bite.
The traditional Chinese medicine composition provided by the invention can be prepared into external dosage forms suitable for medicines according to the conventional pharmaceutical technology by adding pharmaceutically conventional auxiliary materials or carriers, including but not limited to paste, tincture and powder. Preferably, the invention also provides a traditional Chinese medicine preparation taking the traditional Chinese medicine composition as a medicine active ingredient.
The invention also provides a preparation method of the external ointment taking the traditional Chinese medicine composition as an active ingredient, which comprises the following steps:
(1) Weighing the raw materials respectively, drying and crushing the raw materials respectively to obtain fine powder of the raw materials, wherein the particle size of the fine powder of the raw materials is preferably 80-120 meshes, more preferably 100 meshes; uniformly mixing the raw material fine powder to obtain mixed medicinal powder;
(2) Adding Chinese liquor into the mixed powder, stirring, standing, adding melted Vaseline, and stirring to paste. Preferably, the white spirit is white spirit with the alcohol content of more than 60 degrees, the standing is carried out under a sealing condition, and the standing time is 5-9 days; the ratio of the mass of the mixed powder to the volume of the white spirit to the mass of the vaseline is preferably 1.5-2.5:1:0.3, more preferably 2:1:0.3.
The invention also provides application of the traditional Chinese medicine composition, in particular application in preparing medicines for treating bone joint diseases and traumatic injuries, wherein the bone joint diseases comprise but are not limited to cervical spondylosis, lumbar spondylosis, scapulohumeral periarthritis, knee joint diseases and tenosynovitis.
The beneficial effects of the invention are as follows:
according to the traditional Chinese medicine composition for treating arthralgia and myalgia, the obscured homalomena rhizome, tripterygium wilfordii, radix angelicae pubescentis, notopterygium root, rhizoma corydalis, safflower, garden balsam stem, rhizoma drynariae, fructus liquidambaris, asarum, rhizoma cibotii, rhizoma dioscoreae, ligusticum wallichii, angelica sinensis, caulis spatholobi, lycopodium clavatum, ramulus mori, radix angelicae, peach kernel, radix dipsaci, gentiana macrophylla, eucommia ulmoides, radix paeoniae rubrathe, folium artemisiae argyi, achyranthes bidentata, mistletoe, elecampane, pine node, papaya, liquorice, myrrh, frankincense, scorpion, borneol, earthworm, zaocys dhumnade, long-noded pit viper, ground beetle, leech, scorpion and centipede are adopted as raw materials and are subjected to a proper weight ratio, so that the raw materials are mutually matched and act together, and the effects of resisting inflammation and relieving pain, dispelling wind and removing dampness, activating blood stasis, promoting the swelling, calming wind and relieving spasm, dredging meridians and activating collaterals, and tonifying kidney are used for treating various arthralgia and myalgia such as cervical vertebra lumbar vertebra and lumbar vertebra pain, and the curative effect is high.
The preparation method of the external ointment for treating arthralgia and myalgia comprises the following steps: (1) The equipment cost is low, the social benefit is large, the popularization is easy to grasp, and the miniaturization is realized; (2) The required medicinal materials can be fully utilized, the residue is avoided, the energy is saved, the environment is protected, the pure traditional Chinese medicine is not added, the medicinal materials do not need a leaching link, the production period is obviously shortened, the production cost is reduced, and the preparation method has obvious competitive advantages and wide application prospects; (3) The preparation method has the advantages of saving investment, reducing labor, high efficacy and less toxic and side effects, and is suitable for popularization and application.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It will be apparent that the described embodiments are only some, but not all, embodiments of the invention. All other embodiments, based on the examples herein, which are within the scope of the invention as defined by the claims, will be within the scope of the invention as defined by the claims. In the following examples, 1g was represented by 1 part by weight.
Example 1
The embodiment provides a traditional Chinese medicine composition for treating arthralgia and myalgia, which comprises the following raw materials in parts by weight:
2 parts of obscured homalomena rhizome, 2 parts of tripterygium wilfordii, 1 part of radix angelicae pubescentis, 1 part of notopterygium root, 1 part of rhizoma corydalis, 1 part of safflower, 1 part of garden balsam stem, 0.5 part of rhizoma drynariae, 0.5 part of fructus liquidambaris, 0.5 part of asarum herb, 0.5 part of rhizoma cibotii, 0.5 part of rhizoma dioscoreae, 0.5 part of ligusticum wallichii, 0.5 part of angelica sinensis, 0.5 part of caulis spatholobi, 0.5 part of lycopodium clavatum, 0.3 part of mulberry twig, 0.3 part of angelica dahurica, 0.3 part of peach kernel, 0.3 part of teasel root, 0.3 part of gentiana macrophylla, 0.3 part of eucommia bark, 0.3 part of red paeony root, 0.3 part of mugwort leaf, 0.3 part of achyranthes root, 0.3 part of mulberry mistletoe, 0.3 part of Chinese taxillus twig, 0.3 part of costustoot, 0.5 part of pine, 0.3 part of papaya, 0.3 part of liquorice, 0.5 part of frankincense, 0.5 part of blood-long-noded pit viper, 0.1 part of centipede, 1.1 part of scorpion, 1 part of centipede, 1.1 part of scorpion and 1 part of scorpion.
Example 2
The embodiment provides a traditional Chinese medicine composition for treating arthralgia and myalgia, which comprises the following raw materials in parts by weight:
8 parts of obscured homalomena rhizome, 8 parts of tripterygium wilfordii, 5 parts of radix angelicae pubescentis, 5 parts of notopterygium root, 5 parts of rhizoma corydalis, 5 parts of safflower, 5 parts of garden balsam stem, 5 parts of rhizoma drynariae, 5 parts of fructus liquidambaris, 5 parts of asarum herb, 5 parts of rhizoma cibotii, 5 parts of rhizoma dioscoreae, 5 parts of rhizoma ligustici wallichii, 5 parts of angelica sinensis, 5 parts of caulis spatholobi, 5 parts of lycopodium clavatum, 3 parts of ramulus mori, 3 parts of radix angelicae, 3 parts of peach kernel, 3 parts of radix dipsaci, 3 parts of gentianae macrophylla, 3 parts of eucommia bark, 3 parts of radix paeoniae rubra, 3 parts of folium artemisiae argyi, 3 parts of achyranthes bidentata, 3 parts of herba taxilli, 3 parts of elecampane, 3 parts of radix sophorae, 3 parts of pine, 3 parts of papaya, 3 parts of liquorice, 5 parts of myrrh, 5 parts of frankincense, 5 parts of blood scorpion, 5 parts of borneol, 2 parts of earthworm, 2 parts of black-tail snake, 1 part of leech, 1 part of ground beetle, 1 part of scorpion, 1 part of whole centipede, 1 part of centipede, and 1 part of centipede.
Example 3
The embodiment provides a traditional Chinese medicine composition for treating arthralgia and myalgia, which comprises the following raw materials in parts by weight:
3 parts of obscured homalomena rhizome, 3 parts of tripterygium wilfordii, 2 parts of radix angelicae pubescentis, 2 parts of notopterygium root, 2 parts of rhizoma corydalis, 2 parts of safflower, 2 parts of garden balsam stem, 1 part of drynaria rhizome, 1 part of fructus liquidambaris, 1 part of asarum herb, 1 part of rhizoma cibotii, 1 part of rhizoma dioscoreae, 1 part of szechuan lovage rhizome, 1 part of angelica, 1 part of suberect spatholobus stem, 1 part of lycopodium clavatum, 0.5 part of mulberry twig, 0.5 part of dahurian angelica root, 0.5 part of peach seed, 0.5 part of teasel root, 0.5 part of gentiana macrophylla, 0.5 part of eucommia bark, 0.5 part of red paeony root, 0.5 part of mugwort leaf, 0.5 part of achyranthes root, 0.5 part of mistletoe, 0.5 part of costustoot, 0.5 part of pine node, 0.5 part of papaya, 0.5 part of liquorice, 1 part of myrrh, 1 part of scorpion, 1 part of blood, 1 part of borneol, 0.5 part of earthworm, 0.5 part of zaocys dhumnade, 0.3 part of centipede, 3.3 parts of centipede, and 3 parts of ground beetle.
Example 4
The embodiment provides a traditional Chinese medicine composition for treating arthralgia and myalgia, which comprises the following raw materials in parts by weight:
5 parts of obscured homalomena rhizome, 5 parts of tripterygium wilfordii, 4 parts of radix angelicae pubescentis, 4 parts of notopterygium root, 4 parts of rhizoma corydalis, 4 parts of safflower, 4 parts of garden balsam stem, 3 parts of rhizoma drynariae, 3 parts of fructus liquidambaris, 3 parts of asarum herb, 3 parts of rhizoma cibotii, 3 parts of rhizoma dioscoreae, 3 parts of rhizoma ligustici wallichii, 3 parts of angelica sinensis, 3 parts of caulis spatholobi, 3 parts of lycopodium clavatum, 1.5 parts of ramulus mori, 1.5 parts of radix angelicae, 1.5 parts of peach kernel, 1.5 parts of radix dipsaci, 1.5 parts of gentianae macrophylla, 1.5 parts of eucommia ulmoides, 1.5 parts of radix paeoniae rubra, 1.5 parts of mugwort leaf, 1.5 parts of achyranthes bidentata, 1.5 parts of herba taxilli, 1.5 parts of costus root, 1.5 parts of pine, 1.5 parts of pawpaw, 3 parts of liquorice, 3 parts of myrrh, 3 parts of scorpio, 3 parts of blood, 3 parts of borneol, 1.5 parts of radix ophiopogonis, 1.5 parts of earthworm, 1.5 parts of Zaocys, 1.8.8, 0.8 parts of centipede and 0.0 part of scorpion.
Example 5
The embodiment provides a traditional Chinese medicine composition for treating arthralgia and myalgia, which comprises the following raw materials in parts by weight:
4 parts of obscured homalomena rhizome, 4 parts of tripterygium wilfordii, 3 parts of radix angelicae pubescentis, 3 parts of notopterygium root, 3 parts of rhizoma corydalis, 3 parts of safflower, 3 parts of garden balsam stem, 2 parts of rhizoma drynariae, 2 parts of fructus liquidambaris, 2 parts of asarum herb, 2 parts of rhizoma cibotii, 2 parts of rhizoma dioscoreae, 2 parts of rhizoma ligustici wallichii, 2 parts of angelica sinensis, 2 parts of caulis spatholobi, 2 parts of lycopodium clavatum, 1 part of ramulus mori, 1 part of radix angelicae, 1 part of peach kernel, 1 part of radix dipsaci, 1 part of gentianae macrophylla, 1 part of eucommia bark, 1 part of radix paeoniae rubra, 1 part of folium artemisiae argyi, 1 part of achyranthes bidentata, 1 part of herba taxilli, 1 part of elecampane, 1 part of radix aucklandiae, 1 part of pine, 1 part of papaya, 1 part of liquorice, 2 parts of myrrh, 2 parts of frankincense, 2 parts of blood scorpion, 2 parts of borneol, 1 part of earthworm, 1 part of black-tail, 0.5 part of snake, 0.5 part of ground beetle, 0.5 part of white leech, 0.5 part of centipede and 0.5 part of centipede.
Example 6
The present embodiment provides an external ointment using the traditional Chinese medicine composition of embodiment 5 as a pharmaceutical active ingredient, and the preparation method is as follows:
(1) Weighing the raw materials, respectively drying and pulverizing to obtain 100 mesh fine powder; uniformly mixing the raw material fine powder to obtain mixed medicinal powder;
(2) Adding 60% (v/v) Chinese liquor into the mixed powder, stirring, standing under sealed condition for 7 days, adding melted vaseline, and stirring to paste (mixed powder: chinese liquor: vaseline=2:1:0.3).
Example 7
The present embodiment provides an external ointment using the traditional Chinese medicine composition of embodiment 4 as a pharmaceutical active ingredient, and the preparation method is as follows:
(1) Weighing the raw materials, respectively drying and pulverizing to obtain fine powder with particle diameter of 80 mesh; uniformly mixing the raw material fine powder to obtain mixed medicinal powder;
(2) Adding 60% (v/v) Chinese liquor into the mixed powder, stirring, standing under sealed condition for 5 days, adding melted vaseline, and stirring to paste (mixed powder: chinese liquor: vaseline=1.5:1:0.3).
Example 8
The present embodiment provides an external ointment using the traditional Chinese medicine composition of embodiment 3 as a pharmaceutical active ingredient, and the preparation method is as follows:
(1) Weighing the raw materials, respectively drying and pulverizing to obtain fine powder with particle diameter of 120 mesh; uniformly mixing the raw material fine powder to obtain mixed medicinal powder;
(2) Adding 60% (v/v) Chinese liquor into the mixed powder, stirring, standing under sealed condition for 9 days, adding melted vaseline, and stirring to paste (mixed powder: chinese liquor: vaseline=2.5:1:0.3).
Comparative example
The difference from example 6 is that the yam rhizome of the traditional Chinese medicine composition is removed, and specifically, the raw material components of the traditional Chinese medicine composition of the comparative example comprise: 4 parts of obscured homalomena rhizome, 4 parts of tripterygium wilfordii, 3 parts of radix angelicae pubescentis, 3 parts of notopterygium root, 3 parts of rhizoma corydalis, 3 parts of safflower, 3 parts of garden balsam stem, 2 parts of rhizoma drynariae, 2 parts of fructus liquidambaris, 2 parts of asarum, 2 parts of rhizoma cibotii, 2 parts of ligusticum wallichii, 2 parts of angelica sinensis, 2 parts of caulis spatholobi, 2 parts of lycopodium clavatum, 3 parts of ramulus mori, 1 part of radix angelicae, 1 part of peach kernel, 1 part of radix dipsaci, 1 part of gentianae macrophylla, 1 part of eucommia ulmoides, 1 part of radix paeoniae rubra, 1 part of folium artemisiae argyi, 1 part of achyranthes bidentata, 1 part of herba taxilli, 1 part of costustoot, 1 part of pine, 1 part of papaya, 1 part of liquorice, 2 parts of myrrh, 2 parts of scorpion, 2 parts of blood scorpion, 2 parts of borneol, 1 part of earthworm, 1 part of zaocys dhumnade, 0.5 part of long-nodus, 0.5 part of ground beetle, 0.5 part of leech, 0.5 part of whole body, 0.5 part of centipede and 0.5 part of centipede.
The clinical overall treatment effect test and research of the invention
1. The general data selects 208 cases of patients with bone joint pain, and the patients are randomly divided into 106 cases of test groups, including 50 cases of men, 56 cases of women and ages 55-70 years old, wherein the cervical vertebra pain is 12 cases, the lumbar vertebra pain is 48 cases and the knee joint pain is 46 cases; 52 cases of control 1 group, including 24 cases of men, 28 cases of women, ages 53-65 years, wherein 6 cases of cervical pain, 24 cases of lumbar pain, 22 cases of knee joint pain; the control group 2 had 50 cases, including 23 men, 27 women, and ages 55-70, with 6 cases of cervical pain, 22 cases of lumbar pain, and 22 cases of knee joint pain.
2. Treatment methods test group and control group 1 were respectively given the external ointment (appropriate amount of the ointment is filled into the medicinal ointment patch and applied to the affected part, one patch each day) of the invention example 6 and comparative example, and the musk rheumatalgia-relieving ointment is given to control group 2, one patch each day, and each group is continuously treated for 7 days.
3. Curative effect standard cure: the local pain is completely eliminated, and the exercise function is recovered to be normal; the effect is shown: the local pain is obviously relieved, the swelling disappears, and the exercise function is basically recovered; the method is effective: the local pain is relieved, the swelling is relieved, and the exercise function is limited; invalidation: symptoms are the same as before.
4. The therapeutic effect is shown in Table 1.
TABLE 1 statistics of overall therapeutic effect
The results show that the total effective rates of the test group, the control 1 group and the control 2 group are 100%, 92.31% and 82.00%, respectively, and the test group is obviously better than the other groups, namely, the plaster adopting the traditional Chinese medicine composition of the embodiment 5 of the invention has obviously better treatment effect than the plaster adopting the traditional Chinese medicine composition of the embodiment 5 without yam rhizome, and has outstanding advantages compared with the commercial products, which indicates that the embodiment 5 of the invention has scientific raw material compatibility, reasonable proportion, can obviously relieve pain of patients with osteoarthropathy, and has the characteristics of quick response and obvious curative effect.
The invention can effectively relieve bone joint pain, has better treatment effect on pain caused by traumatic injury and the like, and is a representative specific case.
TABLE 2 typical treatment cases
The foregoing is merely illustrative of the present invention, and the present invention is not limited thereto, and any person skilled in the art will readily recognize that variations or substitutions are within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims (7)

1. The externally-applied traditional Chinese medicine composition for treating arthralgia and myalgia is characterized by comprising the following raw materials in parts by weight:
3-5 parts of obscured homalomena rhizome, 3-5 parts of tripterygium wilfordii, 2-4 parts of radix angelicae pubescentis, 2-4 parts of notopterygium root, 2-4 parts of rhizoma corydalis, 2-4 parts of safflower, 2-4 parts of garden balsam stem, 1-3 parts of rhizoma drynariae, 1-3 parts of fructus liquidambaris, 1-3 parts of asarum, 1-3 parts of rhizoma cibotii, 1-3 parts of rhizoma dioscoreae, 1-3 parts of ligusticum wallichii, 1-3 parts of angelica sinensis, 1-3 parts of spatholobus stem, 1-3 parts of lycopodium clavatum, 0.5-1.5 parts of mulberry twig, 0.5-1.5 parts of angelica dahurica, 0.5-1.5 parts of peach seed, 0.5-1.5 parts of teasel root, 0.5-1.5 parts of large-leaved gentian, 1.5 parts of rhizoma dioscoreae 0.5 to 1.5 weight parts of eucommia bark, 0.5 to 1.5 weight parts of red paeony root, 0.5 to 1.5 weight parts of mugwort leaf, 0.5 to 1.5 weight parts of achyranthes root, 0.5 to 1.5 weight parts of Chinese taxillus twig, 0.5 to 1.5 weight parts of costustoot, 0.5 to 1.5 weight parts of pine node, 0.5 to 1.5 weight parts of papaya, 0.5 to 1.5 weight parts of liquorice, 1 to 3 weight parts of myrrh, 1 to 3 weight parts of frankincense, 1 to 3 weight parts of blood scorpion, 1 to 3 weight parts of borneol, 0.5 to 1.5 weight parts of earthworm, 0.5 to 1.5 weight parts of black-tail snake, 0.3 to 0.8 weight parts of long-noded pit viper, 0.3 to 0.8 weight parts of ground beetle, 0.3 to 0.8 weight parts of leech, 0.3 to 0.8 weight parts of scorpion and 0.3 to 0.8 weight part of centipede.
2. The external traditional Chinese medicine composition for treating arthralgia and myalgia according to claim 1, wherein the external traditional Chinese medicine composition comprises the following raw materials in parts by weight:
4 parts of obscured homalomena rhizome, 4 parts of tripterygium wilfordii, 3 parts of radix angelicae pubescentis, 3 parts of notopterygium root, 3 parts of rhizoma corydalis, 3 parts of safflower, 3 parts of garden balsam stem, 2 parts of rhizoma drynariae, 2 parts of fructus liquidambaris, 2 parts of asarum herb, 2 parts of rhizoma cibotii, 2 parts of rhizoma dioscoreae, 2 parts of rhizoma ligustici wallichii, 2 parts of angelica sinensis, 2 parts of caulis spatholobi, 2 parts of lycopodium clavatum, 1 part of ramulus mori, 1 part of radix angelicae, 1 part of peach kernel, 1 part of radix dipsaci, 1 part of gentianae macrophylla, 1 part of eucommia bark, 1 part of radix paeoniae rubra, 1 part of folium artemisiae argyi, 1 part of achyranthes bidentata, 1 part of herba taxilli, 1 part of elecampane, 1 part of radix aucklandiae, 1 part of pine, 1 part of papaya, 1 part of liquorice, 2 parts of myrrh, 2 parts of frankincense, 2 parts of blood scorpion, 2 parts of borneol, 1 part of earthworm, 1 part of black-tail, 0.5 part of snake, 0.5 part of ground beetle, 0.5 part of white leech, 0.5 part of centipede and 0.5 part of centipede.
3. A Chinese medicinal preparation for external use for treating arthralgia and myalgia, which is characterized by comprising the Chinese medicinal composition according to any one of claims 1-2 and a pharmaceutically acceptable carrier.
4. The external-use Chinese medicinal preparation for treating arthralgia and myalgia of claim 3, wherein the dosage form of the Chinese medicinal preparation is an external-use ointment.
5. The external-use Chinese medicinal preparation for treating arthralgia and myalgia of claim 4, wherein the preparation method of the external-use ointment comprises the following steps:
(1) Weighing the raw materials respectively, and drying and crushing the raw materials respectively to obtain fine powder of the raw materials; uniformly mixing the raw material fine powder to obtain mixed medicinal powder;
(2) Adding Chinese liquor into the mixed powder, stirring, standing, adding melted Vaseline, and stirring to paste.
6. The method for preparing a topical paste for treating bone and muscle pain according to claim 5, wherein in the step (1), the particle size of each of the raw material fine powders is 80-120 mesh.
7. The method for preparing an external ointment for treating arthralgia and myalgia according to claim 5, wherein in the step (2), the white spirit is 60 ° or more white spirit, the standing is performed under a sealed condition, and the standing time is 5 to 9 days; the ratio of the mass of the mixed powder to the volume of the white wine to the mass of the Vaseline is 1.5-2.5:1:0.3.
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