CN111084842B - External traditional Chinese medicine composition for treating scapulohumeral periarthritis, cervical spondylosis, lumbar disc herniation and osteoarthritis - Google Patents

External traditional Chinese medicine composition for treating scapulohumeral periarthritis, cervical spondylosis, lumbar disc herniation and osteoarthritis Download PDF

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CN111084842B
CN111084842B CN202010096108.0A CN202010096108A CN111084842B CN 111084842 B CN111084842 B CN 111084842B CN 202010096108 A CN202010096108 A CN 202010096108A CN 111084842 B CN111084842 B CN 111084842B
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osteoarthritis
traditional chinese
cervical spondylosis
scapulohumeral periarthritis
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CN111084842A (en
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高永学
刘夔
田耀武
段峰彦
徐桃娟
徐宁宁
李鹏杰
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Gansu minzhou Kangyang Pharmaceutical Technology Co.,Ltd.
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Minxian Tiecheng Honglian Biomedical Technology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/21Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/237Notopterygium
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286Carthamus (distaff thistle)
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288Taraxacum (dandelion)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • A61K36/428Trichosanthes
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704Polygonum, e.g. knotweed
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    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708Rheum (rhubarb)
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/732Chaenomeles, e.g. flowering quince
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/889Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • A61K9/00Medicinal preparations characterised by special physical form
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

The invention discloses an external traditional Chinese medicine composition for treating scapulohumeral periarthritis, cervical spondylosis, lumbar disc herniation and osteoarthritis, which comprises the following raw materials in parts by weight: 55-65 parts of sambucus chinensis, 30-38 parts of rheum officinale, 75-85 parts of dandelion, 22-28 parts of pawpaw, 20-30 parts of angelica sinensis, 20-30 parts of lumbricus, 20-30 parts of herba lycopi, 30-38 parts of betel nut, 30-40 parts of radix achyranthis bidentatae, 30-40 parts of eupolyphaga, 30-40 parts of resina draconis, 50-60 parts of pseudo-ginseng, 33-40 parts of radix trichosanthis, 30-38 parts of polygonum cuspidatum, 30-40 parts of safflower, 50-60 parts of notopterygium root and 50-60 parts of radix angelicae pubescentis. The traditional Chinese medicine composition can effectively relieve local pain of scapulohumeral periarthritis, cervical spondylosis, lumbar disc herniation, osteoarthritis or fracture dislocation tendon injury, has the curative effects of promoting blood circulation to remove blood stasis, promoting qi circulation to remove blood stasis, and relieving swelling and pain, is quick in effect, reliable in curative effect, and capable of achieving local external application, and reduces side effects of systemic medication.

Description

External traditional Chinese medicine composition for treating scapulohumeral periarthritis, cervical spondylosis, lumbar disc herniation and osteoarthritis
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to an external traditional Chinese medicine composition for treating scapulohumeral periarthritis, cervical spondylosis, lumbar disc herniation and osteoarthritis.
Background
Scapulohumeral periarthritis, cervical spondylosis, lumbar disc herniation, osteoarthritis and the like belong to common diseases, and have high clinical morbidity and long treatment period. The scapulohumeral periarthritis is a common disease with shoulder joint pain and inconvenient movement as main symptoms, the shoulder joint is the joint with the largest moving range among all joints of the whole body of a human body, the joint capsule is loose, the shoulder joint moves frequently in life, and if the scapulohumeral periarthritis cannot be effectively treated, the functional movement of the shoulder joint is possibly seriously influenced. Cervical spondylosis is also called cervical syndrome, common symptoms of patients are migraine, dizziness, chest distress, chest pain and the like, and the current main treatment methods are traction treatment, acupuncture treatment, massage treatment, physiotherapy treatment and drug treatment. Lumbar intervertebral disc protrusion often causes pain in waist and lower extremities, is the most common clinical disease of pain department, and the currently effective treatment methods are intradiscal hyperthermia and ozone nucleus pulposus dissolving therapy. Osteoarthritis is a chronic joint disease, belongs to early joint aging, particularly joint cartilage aging, has slow onset, is frequently a multi-joint disease, has persistent dull pain in affected joints and joint stiffness, is usually treated by medicines at common parts such as hands, knees, hips, feet, vertebral bodies and the like. Although the treatment methods for the above diseases are more, the treatment period of a single treatment method is longer, and the treatment is usually performed in combination with medicines to improve the curative effect. Therefore, the externally applied traditional Chinese medicine for effectively treating scapulohumeral periarthritis, cervical spondylosis, lumbar disc herniation, osteoarthritis and fracture dislocation muscle injury is provided. The medicine is directly applied to the pathological change part by external application, has high selectivity, and does not act on the pathological change after being absorbed by gastrointestinal tract, thereby eliminating the first-pass effect of the medicine, completely eliminating the stimulation of the gastrointestinal tract of the medicine and greatly reducing the side effect of the medicine.
Disclosure of Invention
Aiming at the defects pointed out in the background technology, the invention provides an external traditional Chinese medicine composition for treating scapulohumeral periarthritis, cervical spondylosis, lumbar disc herniation and osteoarthritis, and provides a practical and effective local external treatment medicine with small toxic and side effects for patients with the diseases.
In order to achieve the purpose, the invention adopts the technical scheme that:
the external traditional Chinese medicine composition for treating scapulohumeral periarthritis, cervical spondylosis, lumbar disc herniation and osteoarthritis is composed of the following raw materials in parts by weight:
55-65 parts of sambucus chinensis, 30-38 parts of rheum officinale, 75-85 parts of dandelion, 22-28 parts of pawpaw, 20-30 parts of angelica sinensis, 20-30 parts of lumbricus, 20-30 parts of herba lycopi, 30-38 parts of betel nut, 30-40 parts of radix achyranthis bidentatae, 30-40 parts of eupolyphaga, 30-40 parts of resina draconis, 50-60 parts of pseudo-ginseng, 33-40 parts of radix trichosanthis, 30-38 parts of polygonum cuspidatum, 30-40 parts of safflower carthamus, 50-60 parts of notopterygium root and 50-60 parts of radix angelicae pubescentis.
Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight:
60-65 parts of sambucus chinensis, 35-38 parts of rheum officinale, 78-80 parts of dandelion, 25-28 parts of pawpaw, 24-28 parts of angelica sinensis, 25-30 parts of lumbricus, 25-30 parts of herba lycopi, 35-38 parts of betel nut, 30-35 parts of radix achyranthis bidentatae, 30-35 parts of eupolyphaga, 35-40 parts of resina draconis, 55-60 parts of pseudo-ginseng, 35-38 parts of radix trichosanthis, 35-38 parts of polygonum cuspidatum, 35-40 parts of safflower carthamus, 55-60 parts of notopterygium root and 55-60 parts of radix angelicae pubescentis.
Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight:
60 parts of herba sambuci chinensis, 35 parts of rheum officinale, 80 parts of dandelion, 25 parts of pawpaw, 25 parts of angelica sinensis, 25 parts of lumbricus, 25 parts of herba lycopi, 35 parts of betel nut, 35 parts of radix achyranthis bidentatae, 35 parts of eupolyphaga, 35 parts of scorpion, 55 parts of pseudo-ginseng, 35 parts of radix trichosanthis, 35 parts of polygonum cuspidatum, 35 parts of safflower carthamus, 55 parts of notopterygium root and 55 parts of radix angelicae pubescentis.
The invention further provides application of the traditional Chinese medicine composition in preparing medicines for treating scapulohumeral periarthritis, cervical spondylosis, lumbar disc herniation and osteoarthritis.
Preferably, the Chinese medicinal composition can be prepared into a plaster or a spray for external use.
Compared with the defects and shortcomings of the prior art, the invention has the following beneficial effects:
the external traditional Chinese medicine composition has the functions of promoting blood circulation to remove blood stasis, relieving swelling and pain and reuniting bones, and the Chinese elder herb contained in the composition has obvious pain relieving effect, wherein the Chinese elder herb is large in dosage, but is nontoxic; the Chinese medicinal composition has the effects of replenishing blood and tonifying qi, and activating blood and dissolving stasis by using the sambucus chinensis, the eupolyphaga and the dragon blood as monarch medicaments in the main formula, has the effects of relieving pain, removing stasis, stopping bleeding and promoting granulation, and promoting repair of cartilage and inflammatory media by using the sambucus chinensis and the dragon blood, has the effects of assisting the monarch medicaments in strengthening blood circulation and stimulating the menstrual flow, removing stasis and relieving pain, relieves peripheral vascular smooth muscle and tendon spasm, increases blood flow, improves local and peripheral circulation of pathological changes, resists thrombus, relieves pain, diminishes inflammation and enhances the immune function. The pawpaw, the herba lycopi, the radix achyranthis bidentatae and the betel nut have obvious swelling and pain relieving effects, are adjuvant drugs and can assist monarch drugs in taking care of swelling caused by pathological changes and quicken elimination of swelling, and the giant knotweed rhizome, the notopterygium root and the radix angelicae pubescentis have the effects of tonifying kidney, strengthening kidney, dispelling wind and removing dampness, and relieving arthralgia and pain. The composition has effects in replenishing blood, invigorating qi, promoting blood circulation, removing blood stasis, relieving pain, dispelling blood stasis, inducing diuresis, relieving swelling, dispelling pathogenic wind, removing dampness, relieving arthralgia, and relieving pain. And the traditional Chinese medicine for tonifying the kidney is reasonably matched to effectively relieve the local pain of scapulohumeral periarthritis, cervical spondylosis, lumbar disc herniation, osteoarthritis or fracture dislocation and muscle injury, promote blood circulation to remove blood stasis, promote qi circulation to remove blood stasis, relieve swelling and relieve pain, and has quick response and reliable curative effect.
The external traditional Chinese medicine composition can effectively relieve local pain of scapulohumeral periarthritis, cervical spondylosis, lumbar disc herniation, osteoarthritis or fracture dislocation tendon injury, has the effects of promoting blood circulation, removing blood stasis, promoting qi circulation, removing blood stasis, relieving swelling and pain, is quick in effect, has smaller side effect than a whole body medicine for local external use, and is reliable in curative effect.
The mechanism of each raw material medicine in the invention is as follows:
land English: shen nong Ben Cao Jing: sweet, slightly bitter and neutral in nature. Governing arthralgia between bones, spasm and pain of limbs, cold pain of knees and impotence. Treatise on herb Property: can smooth out wind-toxin, uprush beriberi and vexation and oppression. The chemical components comprise chlorogenic acid, alpha-amyinpalmitate, ursolic acid, beta-sitosterol, stigmasterol, campesterol, potassium nitrate, flavone, tannin, etc. Has the functions of promoting blood circulation and removing blood stasis, and can be used for treating traumatic injury, rheumatalgia, and dislocation.
Rhubarb: [ PROPERTIES, WESTERN AND GUIJING ] is bitter and cold. It enters spleen, stomach, large intestine, liver and pericardium meridians. Rhubarb, radix et rhizoma Rhei purges away pathogenic accumulation, clears heat and purges fire, cools blood and detoxifies, dispels stasis and dredges the channels, and promotes diuresis to remove jaundice. Can be used for treating constipation due to excessive heat accumulation, hematemesis, epistaxis, conjunctival congestion, pharyngeal swelling, carbuncle, furuncle, intestinal carbuncle, abdominal pain, blood stasis, amenorrhea, puerperal blood stasis, traumatic injury, damp-heat dysentery, jaundice, dark urine, stranguria, and edema; it can be used for external treatment of burn and scald.
Dandelion: nature and taste: bitter, sweet and cold. It enters liver meridian and stomach meridian. The efficacy is as follows: clearing away heat and toxic material, eliminating swelling and dissipating stagnation, inducing diuresis for treating stranguria, blackening beard and hair, and strengthening tendons and bones. Can be used for treating furuncle, pyogenic infection, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, pulmonary abscess, intestinal abscess, jaundice due to damp-heat pathogen, and stranguria with damp-heat pathogen. It can be used for treating acute mastitis, lymphadenitis, scrofula, furunculosis, acute conjunctivitis, common cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection, and insect bite.
Pawpaw: [ CHARACTERISTIC AND WEIZI JING ] is warm in nature, pungent in flavor and sour. It enters liver, spleen and stomach meridians. The pawpaw has the effects of relaxing tendons, activating collaterals, eliminating dampness, harmonizing stomach and promoting digestion. It can be used for treating rheumatism, loempe, edema, vomiting, diarrhea, spasm of muscle, and food stagnation. The pawpaw is sour, warm, fragrant in smell and mild in drug property, can relax tendons and activate collaterals, and also has the effects of resolving dampness and harmonizing stomach, and is the essential drug for treating vomiting and diarrhea, spasm of muscles, arthralgia, beriberi and edema. Flexible compatibility, various applications, and displaying the characteristics of the mechanical and round methods. For vomiting, diarrhea and spasm of tendons, it is often combined with Huo Xiang, Sha ren and mu Xiang; for swelling and pain due to beriberi, even uprush, it can be combined with Perillae herba, fructus evodiae, Arecae semen, etc.; for arthralgia due to wind-dampness and spasm of tendons and vessels, it is often combined with peony and licorice; for deficiency of qi and blood, it can be applied with radix Codonopsis, radix astragali, radix Angelicae sinensis, and radix rehmanniae Preparata; for weakness of waist and knees due to kidney deficiency, it is often combined with niu xi, xu Duan and Du Zhong; for those with weakness of spleen and stomach and indigestion, it is applied together with Massa Medicata Fermentata and fructus Hordei Germinatus; for edema due to dampness and heavy water, it is combined with Fu Ling and Zhu Ling.
Chinese angelica: shen nong Ben Cao Jing: sweet, pungent and warm, enter liver, heart, spleen and large intestine meridians. Ben Cao gang mu (compendium of materia Medica) moisten intestines, stomach, muscles and bones and skin, treat carbuncle and deep rooted carbuncle, discharge pus and alleviate pain, and nourish blood. Chemical components and pharmacological effects: the product is rich in volatile components, organic acids, saccharides, vitamins, amino acids, inorganic elements, alkaline components, stigmasterol, sitosterol, etc., and has effects of promoting the generation of hemoglobin and erythrocyte, relieving peripheral blood vessel smooth muscle and tendon spasm, increasing blood flow, improving peripheral circulation, resisting thrombi, relieving pain, diminishing inflammation, and enhancing immunity.
Earthworm: clearing away heat, arresting convulsion, calming liver, calming endogenous wind, dredging meridian passage, relieving asthma, and promoting urination. It is suitable for treating fever, mania, hyperpyrexia, unconsciousness, cough and asthma due to lung heat, convulsive epilepsy, convulsion, arthralgia, hemiplegia, numbness of limbs, oliguria, edema, and dysuria.
Herba lycopi: it is from Shen nong Ben Cao Jing. Slightly warm in nature and taste, bitter and pungent in flavor. The functions are mainly used for promoting blood circulation, removing blood stasis, promoting diuresis and relieving swelling. The chemical components comprise volatile oil, flavonoid glycoside, saponin, phenols, saccharides and tannin. The product has effect in reducing blood viscosity. In addition, it has certain effect on improving microcirculation. Promoting blood circulation to remove blood stasis; promoting diuresis and relieving swelling; remove toxicity and cure abscess. Amenorrhea of the housewife; dysmenorrhea; postpartum abdominal pain due to stasis; edema of the symptom; traumatic injury; abscess, swelling and sore.
Betel nut: bitter and pungent in flavor and warm in nature. It enters stomach meridian and large intestine meridian. [ EFFECT AND ACTION ] can expel parasites, eliminate stagnation, promote qi circulation and promote water circulation. Belongs to an anthelmintic. [ Pharmacology research ] to expel parasites; an excitatory choline receptor; resisting pathogenic microorganisms; anti-hypertension; and (4) resisting cancer.
Achyranthes root: it is from Shen nong Ben Cao Jing. [ PROPERTIES AND FLAVOUR ] bitter, sour and neutral. [ GUIJING ] enters liver and kidney meridians. [ FUNCTIONS ] can tonify liver and kidney, strengthen tendons and bones, remove blood stasis, dredge channels, and draw blood downward. Can be used for treating soreness of waist and knees, and weakness of tendons and bones; flaccidity of the lower limbs; amenorrhea due to blood stagnation; dysmenorrhea; postpartum abdominal pain due to blood stasis; abdominal mass; the cell coat is not dropped; hot spraying; blood stranguria; traumatic injury; carbuncle and swelling and malignant sore; swollen and sore throat.
According to records in Bencao gang mu, the dragon blood has warm and flat nature, sweet and salty taste, no toxicity, enters blood system, enters lung, spleen and kidney meridians, and has the obvious effects of promoting blood circulation to remove blood stasis, relieving swelling and pain, astringing to stop bleeding, softening hardness to dissipate stagnation, promoting tissue regeneration and healing sore. The function is as follows: 1. improving microcirculation and regulating endocrine. Promoting blood circulation, removing blood stasis, increasing blood coagulation factor in vivo, stopping bleeding, regulating blood circulation, promoting metabolism, and accelerating lymphatic return. 2. Contains resina Draconis saponin, and has strong antiinflammatory, analgesic and immunity improving effects. 3. Contains antibacterial antiseptic substance, plant defensin, and has effects of removing putrefaction and promoting granulation.
Pseudo-ginseng: pungent, sweet, slightly astringent and warm, entering liver and heart meridians. Compendium of materia Medica: "stop bleeding, disperse blood and relieve pain". Chemical components and pharmacological effects: the product contains notoginsenoside, acanthopanax saponin and beta-sitosterol. Can stop bleeding and shorten the blood coagulation time; has the advantages of remarkable anticoagulation, platelet aggregation inhibition, fibrinolysis promotion and blood viscosity reduction; diminishing inflammation and easing pain.
B, ground beetle: the "Ben Cao Jing Su" (the classic of the materia Medica of S): ting Chong has special effect on curing traumatic injury and reuniting bones and muscles. Herbs that are sufficient for treating yin meridians are also indicated. When considering blood, the true yin in the body also irrigates the bones and channels. If blood stagnates, meridians will not be connected, yin and yang will be well-balanced, so cold and heat should be washed and dried. Salty cold can soften hardness of blood, so it is mainly manifested as blood stagnation in the heart and abdomen, and obstruction of blood in the abdomen. Blood harmonizes ying and wei, cold and heat can be removed, and the channels are well-regulated, so that women can grow up in the morning and evening. It is also indicated for malaria. Contains volatile oil and amino acids. The total amount of the volatile oil is 22.19 percent, the main component is naphthalene, and the content of various fatty aldehydes and aromatic aldehydes is 24.95 percent. Also contains dichlorobenzene, dimethyl disulfide and other components which are not common in traditional Chinese medicines. The total content of amino acids is about 40%, and the amino acids essential to human body account for more than 30% of the total content of amino acids. And beta-sitosterol. Octacosanol, octadecyl glyceryl ether, allantoin and uracil are obtained from the raw materials; cholesterol, palmitic acid 5, 4' -dihydroxy-7-methoxyflavone.
Giant knotweed rhizome: giant knotweed rhizome, being bitter and cold in flavor, has the actions of cooling blood and dispelling blood stasis, so it is called Yi Ling Du Yao (treatise on medicine): strengthen the kidney, strengthen yang and replenish essence, strengthen tendons and bones, and strengthen strength. Applied to the affected part of traumatic injury, and can reunion of fractured tendons and bones. The root and rhizome contain free anthraquinone and anthraglycoside, mainly including emodin, physcion, chrysophanol, anthraglycoside A, emodin monomethyl ether (8-O-beta-D-glucoside B, emodin, labyrin, 6-hydroxy aloe emodin, emodin-8-methyl ether, 6-hydroxy aloe emodin-8-methyl ether, etc.), and stilbene compounds including polydatin, resveratrol 3-O-beta-D-glucoside, D-catechin 2, 5-dimethyl-7-hydroxy chromone glucoside, beta-sitosterol glucoside, etc. for treating amenorrhea, dysmenorrhea, puerperal lochiorrhea, mass accumulation, traumatic injury, rheumatalgia, damp-heat jaundice, leucorrhea, sore and pyogenic infection, venomous snake bite, scald caused by water and fire, etc.
Notopterygium root: [ PROPERTIES, WESTERN AND CHANNEL FENG ] is warm in nature, pungent and bitter in flavor. It enters bladder meridian and kidney meridian. [ EFFECT AND ACTION ] can relieve exterior syndrome, dispel cold, dispel wind, remove dampness, and alleviate pain. For wind-cold type common cold, headache, stiff neck, rheumatic arthralgia, shoulder and back ache, etc., [ pharmacological research ] has the functions of antipyresis, analgesia, anti-inflammatory, anti-allergic, anti-myocardial ischemia, anti-arrhythmia, anti-thrombosis, anti-epilepsy, anti-oxidation, anti-bacteria, prolonging sleep time, inhibiting cancer, etc.
Radix angelicae pubescentis: [ PROPERTIES, WESTERN AND CHANNEL FENG ] is slightly warm in nature, pungent and bitter in taste. It enters kidney and bladder meridians. [ EFFECT AND ACTION ] can dispel pathogenic wind, remove dampness, relieve arthralgia and alleviate pain. Belongs to wind-damp-dispelling and cold-dispersing herbs classified under wind-damp-dispelling herbs. For wind-cold-dampness pain, pain in waist and knees, and shaoyin wind-syndrome headache, animal experiments show that the alcohol extract has platelet aggregation inhibiting and antithrombotic effects, and the active ingredients are dihydrocarveol, dihydrocarveol acetate, etc. The water decoction or fluid extract has sedative, hypnotic, analgesic and antiinflammatory effects on rat. It also has blood pressure lowering and arrhythmia resisting effects; has effects in photosensitizing, relieving spasm, resisting tumor, resisting bacteria, promoting lipolysis, and exciting respiration.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Example 1
Respectively weighing the following medicinal raw materials in parts by weight: 55 parts of sambucus chinensis, 30 parts of rheum officinale, 75 parts of dandelion, 22 parts of pawpaw, 20 parts of angelica, 20 parts of earthworm, 20 parts of herba lycopi, 30 parts of betel nut, 30 parts of achyranthes bidentata, 30 parts of eupolyphaga, 30 parts of scorpion, 50 parts of pseudo-ginseng, 33 parts of trichosanthes root, 30 parts of polygonum cuspidatum, 30 parts of safflower, 50 parts of notopterygium root and 50 parts of radix angelicae pubescentis. Then the raw materials of the medicine are crushed and sieved by a 200-mesh sieve, and are added with matrixes such as 150 parts of tung oil, 800 parts of vaseline and the like to be decocted into paste, and the paste is prepared to be applied to an affected part and is replaced once a day.
Example 2
Respectively weighing the following medicinal raw materials in parts by weight: 60 parts of sambucus chinensis, 35 parts of rheum officinale, 80 parts of dandelion, 25 parts of pawpaw, 25 parts of angelica, 25 parts of earthworm, 25 parts of herba lycopi, 35 parts of betel nut, 35 parts of achyranthes bidentata, 35 parts of eupolyphaga, 35 parts of scorpion, 55 parts of pseudo-ginseng, 35 parts of trichosanthes root, 35 parts of polygonum cuspidatum, 35 parts of safflower carthamus, 55 parts of notopterygium root and 55 parts of radix angelicae pubescentis. Then the raw materials of the medicine are crushed and sieved by a 200-mesh sieve, and are added with 180 parts of tung oil, 1000 parts of vaseline and other matrixes to be decocted into paste, and then the paste is prepared to be applied to the affected part, and the application is changed once a day.
Example 3
Respectively weighing the following medicinal raw materials in parts by weight: 62 parts of herba sambuci chinensis, 32 parts of rheum officinale, 82 parts of dandelion, 25 parts of pawpaw, 28 parts of angelica sinensis, 28 parts of lumbricus, 26 parts of herba lycopi, 35 parts of betel nut, 38 parts of achyranthes bidentata, 38 parts of eupolyphaga, 38 parts of scorpion, 60 parts of pseudo-ginseng, 38 parts of trichosanthes root, 38 parts of polygonum cuspidatum, 38 parts of safflower carthamus, 58 parts of notopterygium root and 55 parts of radix angelicae pubescentis. Then the raw materials of the medicine are crushed and sieved by a 200-mesh sieve, and are added with 200 parts of tung oil, 1000 parts of vaseline and other matrixes to be decocted into paste, and then the paste is prepared to be applied to the affected part, and the application is changed once a day.
Example 4
Respectively weighing the following medicinal raw materials in parts by weight: 65 parts of Chinese elderberry, 38 parts of rhubarb, 85 parts of dandelion, 28 parts of pawpaw, 30 parts of angelica, 30 parts of earthworm, 30 parts of eupatorium japonicum, 38 parts of betel nut, 40 parts of achyranthes, 40 parts of eupolyphaga, 40 parts of scorpion, 60 parts of pseudo-ginseng, 40 parts of trichosanthes root, 38 parts of giant knotweed, 40 parts of safflower, 60 parts of notopterygium root and 60 parts of pubescent angelica root. Then the raw materials are crushed and sieved by a 200-mesh sieve, and then are put into a pot to be decocted into paste by matrixes such as 200 parts of tung oil, 1200 parts of vaseline and the like, and then the paste is prepared into a paste patch to be applied to an affected part, and the application is changed once a day.
The application method of the traditional Chinese medicine composition can be used for preparing the plaster of embodiment 1-4 and preparing the spray for treating the affected part. The invention selects specific traditional Chinese medicines and dosage through pharmacological analysis, and the prepared medicine has outstanding curative effect on treating scapulohumeral periarthritis, cervical spondylosis, lumbar disc herniation, osteoarthritis or local pain of fracture dislocation and muscle injury.
To further demonstrate the therapeutic effect of the drug of the present invention, the following clinical tests were conducted on the patches prepared in examples 1 to 4, and the results are shown in table 1:
and (3) healing: clinical symptoms disappear, and the function is normal;
the effect is shown: clinical symptoms basically disappear, the function is basically normal, and the disease symptoms are relieved by more than 90 percent;
the method has the following advantages: clinical symptoms basically disappear, the function is basically normal, and the disease symptoms are relieved by more than 80 percent;
the effect is poor: the clinical symptoms are reduced by about 50 percent.
TABLE 1 results of clinical trials conducted on plasters prepared in examples 1-4
Figure 464332DEST_PATH_IMAGE001
As can be seen from table 1, the plaster prepared from the Chinese medicinal composition of embodiments 1 to 4 of the present invention has a prominent curative effect on the local pain of scapulohumeral periarthritis, cervical spondylosis, lumbar disc herniation, osteoarthritis or fracture dislocation tendon injury.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.

Claims (5)

1. The external traditional Chinese medicine composition for treating scapulohumeral periarthritis, cervical spondylosis, lumbar disc herniation and osteoarthritis is characterized by comprising the following raw materials in parts by weight: 55-65 parts of sambucus chinensis, 30-38 parts of rheum officinale, 75-85 parts of dandelion, 22-28 parts of pawpaw, 20-30 parts of angelica sinensis, 20-30 parts of lumbricus, 20-30 parts of herba lycopi, 30-38 parts of betel nut, 30-40 parts of radix achyranthis bidentatae, 30-40 parts of eupolyphaga, 30-40 parts of resina draconis, 50-60 parts of pseudo-ginseng, 33-40 parts of radix trichosanthis, 30-38 parts of polygonum cuspidatum, 30-40 parts of safflower carthamus, 50-60 parts of notopterygium root and 50-60 parts of radix angelicae pubescentis.
2. The external traditional Chinese medicine composition for treating scapulohumeral periarthritis, cervical spondylosis, lumbar disc herniation and osteoarthritis according to claim 1, wherein the composition is prepared from the following raw materials in parts by weight: 60-65 parts of sambucus chinensis, 35-38 parts of rheum officinale, 78-80 parts of dandelion, 25-28 parts of pawpaw, 24-28 parts of angelica sinensis, 25-30 parts of lumbricus, 25-30 parts of herba lycopi, 35-38 parts of betel nut, 30-35 parts of radix achyranthis bidentatae, 30-35 parts of eupolyphaga, 35-40 parts of resina draconis, 55-60 parts of pseudo-ginseng, 35-38 parts of radix trichosanthis, 35-38 parts of polygonum cuspidatum, 35-40 parts of safflower carthamus, 55-60 parts of notopterygium root and 55-60 parts of radix angelicae pubescentis.
3. The external traditional Chinese medicine composition for treating scapulohumeral periarthritis, cervical spondylosis, lumbar disc herniation and osteoarthritis according to claim 1, wherein the composition is prepared from the following raw materials in parts by weight: 60 parts of herba sambuci chinensis, 35 parts of rheum officinale, 80 parts of dandelion, 25 parts of pawpaw, 25 parts of angelica sinensis, 25 parts of lumbricus, 25 parts of herba lycopi, 35 parts of betel nut, 35 parts of radix achyranthis bidentatae, 35 parts of eupolyphaga, 35 parts of scorpion, 55 parts of pseudo-ginseng, 35 parts of radix trichosanthis, 35 parts of polygonum cuspidatum, 35 parts of safflower carthamus, 55 parts of notopterygium root and 55 parts of radix angelicae pubescentis.
4. Use of a composition according to any one of claims 1 to 3 for the preparation of a medicament for the treatment of scapulohumeral periarthritis, cervical spondylosis, lumbar disc herniation, osteoarthritis.
5. The use of claim 4, wherein the composition is formulated as a patch or spray for external use.
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