CN105232888A - Traditional Chinese medicine combination for treating itchy skin after hemodialysis - Google Patents

Abstract

Disclosed is a traditional Chinese medicine combination for treating itchy skin after hemodialysis. The active pharmaceutical ingredients of the traditional Chinese medicine include Blumea megacephala, Japanese coniogramme rhizome, Tribulus terrestris, Chinese lizardtail rhizome, Eucommia bark, Buddleja asiatica, northern radix sileris, feather cockscomb seed, Sapium discolor root, multiflower knotweed vine, Scutellaria indica, gentian root, oriental wormwood, human placenta, Paris polyphylla, cnidium fruit, paniculate swallowwort root, parslane herb, mint, Rhizoma fagopyri cymosi, Chinese angelica root, giant knotweed rhizome, indigowoad leaf, sophora flower bud, astragalus root, Ventilago leiocarpa benth, Solanum vine, cicada shell and licorice root. The traditional Chinese medicine combination has medicine compatibility, thereby having efficacies of activating and nourishing blood, clearing heat and removing toxicity and dispelling wind and stopping itching; the traditional Chinese medicine combination has a remarkable treatment effect in itching after renal dialysis and is safe and free of toxic and side effects; and with the traditional Chinese medicine combination, the living quality of a patient after going through renal dialysis can be improved remarkably.

Description

A kind of Chinese medicine composition for the treatment of skin pruritus after hemodialysis

Technical field

The invention belongs to medical art, relate to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition for the treatment of skin pruritus after hemodialysis.

Background technology

Chronic renal failure enters the patient of hemodialysis latter stage in cumulative year after year end, occur that skin pruritus is the common skin symptom of Maintenance Hemodialysis Patients after hemodialysis, the reason of chronic kidney hypofunction skin pruritus is still not exclusively clear at present, Recent study show may with blood urea nitrogen during renal failure, flesh liver, the metabolite retentions such as uric acid, to skin irritation, smegma reduces and sweat gland atrophy causes xerosis cutis relevant, also likely with secondary hyperparathyroidism, calcium and phosphorus metabolism disorder, hypervitaminosis A, the allergy of heparin and dialyzer composition, and the middle molecule toxins accumulation in vivo that conventional hemodialysis is difficult to appear is relevant, therefore how plain coefficient result is thought.

Along with the development of blood purification technology and the increasing uremic patient of the improvement of living condition obtain effective treatment.Dialysis ages extends gradually washes one's hair several growing with each passing day, and related complication of simultaneously dialysing also constantly occurs that this has had a strong impact on the quality of life of uremic patient.Skin pruritus is that a kind of complication that is common and that be difficult to tolerate has had a strong impact on the life quality of patient.Before having bibliographical information to dialyse, the incidence rate of pruritus is 36%, and the incidence rate after dialysis then up to 60%--90%, and 10% is wherein obstinate pruritus.If can not timely and effectively carry out treatment serious complication may be caused to add scratch, have a sleepless night, depressed etc. and medical expense may be increased because of concurrent skin infection.Therefore analyzing skin pruritus Producing reason takes measure timely and effectively to have important meaning to the life quality improving patient.

Domestic Nephrology doctor has carried out 20 years of researches around the generation mechanism of Uremia skin pruritus.

The reason of dialysis patient skin pruritus:

1. detoxifying function: vivotoxin savings adds dialysis and insufficiently easily causes skin pruritus.Dialysis patient skin exists multiple pathological change makes skin lesion cause microangiopathies and produce corresponding skin pruritus.

2. calcium and phosphorus metabolism disorder: patients of chronic renal failure due to row phosphorus reduce answer phosphorus level repeatedly raise blood ionized calcium level decline may affect skin cylindrical cell release histamine and 5-hydroxy tryptamine etc. cause material of itching.

3. secondary hyperparathyroidism: parathyroid hormone (PTH) is a kind of endocrine hormone of pth secretion is regulate the key factor of alcium and phosphor metabolization in human body to wash one's hair nearly all organ in body to be the target organ of PTH effect.Secondary hyperparathyroidism plays an important role in uremic pruritus to have scholar to think, can cause calcareous infarct in skin histology and increase, and blood middle and high concentration PTH can discharge histamine and cause skin pruritus by chafe mastocyte simultaneously.Simultaneously PTH be in, the little weak effect removed by disperse of plasma concentration Concentraton gradient on the low side of macromolecular substances this kind of material is so simple dialysis easily causes pruritus to lower the opening of its clearance rate.

4. to dialyse correlative factor: hemodialysis can only play excretion micromolecule poisonous substance and moisture effect and in can not degrading or drain, macromolecular substances the latter easily accumulation thus cause or increase the weight of the pruritus of maintenance hemodialysis uremic patient in vivo.Dialysis adds patient and the contact causing material of itching.The dialyser of extracorporeal circulation, vascular access, puncture plastics needle handle and anticoagulant used, as heparin; The ethylene oxide gas, iodine tincture, ethanol etc. of adhesive plaster, sterilization all can cause allergy and skin pruritus occur in addition.In blood dialysis, kind dialyzer in Lip river all can produce the performance that head syndrome anaphylactic type patient can have skin pruritus by activating complement to some extent.

5. xerosis cutis: xerosis cutis is one of common cutaneous manifestations of uremic patient.In the perspiration of patient skin secretion, the concentration of carbamide is up to 50 times of serum-concentration, and occurs the dry skewer gland of the dehydration outward appearance of keratodermatitis, sebaceous gland atrophy secretion is low thus causes skin Secondary cases pruritus.

6. malnutrition: though patient often occurs that the dialysis of the symptom such as anorexia, Nausea and vomiting can increase breaks down proteins when can alleviate hemodialysis when can not eliminate completely thus cause loss of appetite nutrition intake deficiency to watch and aminoacid is lost, easily cause malnutrition and vitamin Deficiency of Intake Keratoderma obviously to cause xerosis cutis in the course of time.

7. underlying diseases: diabetes, malignant lymphoma, uremia's companion's hypercalcemia and secondary hyperparathyroidism patient Yi Yinqi skin pruritus.

8. Personal hygiene: uremic patient body constitution is more weak opens easy catching a cold.The patient putting pipe inconvenience of taking action maybe dare not have a bath, change underwear and cause skin pruritus.

Skin pruritus a kind ofly all brings painful common complication to Maintenance Hemodialysis Patients at physiology and psychology but the reason occurred due to pruritus and mechanism are still not clear, and still solves this difficult problem without special effective method and measure clinically at present.Doctor trained in Western medicine is often with Loratadine treatment or the treatment of change dialysis mode, but unsatisfactory curative effect, and Loratadine often has side effect.

Summary of the invention

The present invention is directed to weak point of the prior art, provide a kind of Chinese medicine composition for the treatment of skin pruritus after hemodialysis, this Chinese medicine composition has effect of nourishing blood and promoting blood circulation, heat-clearing and toxic substances removing, dispelling wind for relieving itching, and safety has no side effect.

For achieving the above object, present invention employs following technical scheme:

Treat a Chinese medicine composition for skin pruritus after hemodialysis, the crude drug of described Chinese medicine composition is made up of Herba Blumeae clarkei, Coniogramme japonica (Thunb.) Diels, Fructus Atriplicis Sibiricae, Rhizoma Saururi (Herba Saururi), Cortex Eucommiae, Buddleja asiatica, Radix Saposhnikoviae, Semen Celosiae, Radix Sapii Discoloris, Caulis Polygoni Multiflori, Herba Scutellariae indicae, Radix Gentianae, Herba Artemisiae Scopariae, Placenta Hominis, Rhizoma Paridis, Fructus Cnidii, Radix Cynanchi Paniculati, Herba Portulacae, Herba Menthae, Rhizoma Fagopyri Dibotryis, Radix Angelicae Sinensis, Rhizoma Polygoni Cuspidati, Folium Isatidis, the Flos Sophorae Immaturus, the Radix Astragali, Radix seu Caulis Verntilaginis Leiocarpae, Herba Solani Lyrati, Periostracum Cicadae, Radix Glycyrrhizae.

Further, crude drug composition and the parts by weight of making described Chinese medicine composition are: Herba Blumeae clarkei 4-6 part, Coniogramme japonica (Thunb.) Diels 8-12 part, Fructus Atriplicis Sibiricae 3-4 part, Rhizoma Saururi (Herba Saururi) 12-15 part, Cortex Eucommiae 5-9 part, Buddleja asiatica 3-4 part, Radix Saposhnikoviae 5-8 part, Semen Celosiae 12-20 part, Radix Sapii Discoloris 10-16 part, Caulis Polygoni Multiflori 3-8 part, Herba Scutellariae indicae 5-12 part, Radix Gentianae 12-17 part, Herba Artemisiae Scopariae 7-12 part, Placenta Hominis 4-9 part, Rhizoma Paridis 15-20 part, Fructus Cnidii 10-15 part, Radix Cynanchi Paniculati 8-12 part, Herba Portulacae 2-5 part, Herba Menthae 3-7 part, Rhizoma Fagopyri Dibotryis 11-14 part, Radix Angelicae Sinensis 9-15 part, Rhizoma Polygoni Cuspidati 3-6 part, Folium Isatidis 8-13 part, Flos Sophorae Immaturus 3-5 part, Radix Astragali 1-3 part, Radix Glycyrrhizae 5-10 part, Radix seu Caulis Verntilaginis Leiocarpae 9-15 part, Herba Solani Lyrati 3-7 part, Periostracum Cicadae 8-12 part.

Further, crude drug composition and the parts by weight of making described Chinese medicine composition are: Herba Blumeae clarkei 6 parts, Coniogramme japonica (Thunb.) Diels 8 parts, Fructus Atriplicis Sibiricae 3 parts, Rhizoma Saururi (Herba Saururi) 15 parts, Cortex Eucommiae 5 parts, Buddleja asiatica 3 parts, Radix Saposhnikoviae 5 parts, Semen Celosiae 12 parts, Radix Sapii Discoloris 16 parts, Caulis Polygoni Multiflori 3 parts, Herba Scutellariae indicae 12 parts, Radix Gentianae 12 parts, Herba Artemisiae Scopariae 10 parts, Placenta Hominis 9 parts, Rhizoma Paridis 15 parts, Fructus Cnidii 15 parts, Radix Cynanchi Paniculati 8 parts, Herba Portulacae 5 parts, Herba Menthae 3 parts, Rhizoma Fagopyri Dibotryis 14 parts, Radix Angelicae Sinensis 9 parts, Rhizoma Polygoni Cuspidati 6 parts, Folium Isatidis 8 parts, the Flos Sophorae Immaturus 5 parts, the Radix Astragali 1 part, 10 parts, Radix Glycyrrhizae, Radix seu Caulis Verntilaginis Leiocarpae 15 parts, Herba Solani Lyrati 3 parts, Periostracum Cicadae 8 parts.

Further, crude drug composition and the parts by weight of making described Chinese medicine composition are: Herba Blumeae clarkei 4 parts, Coniogramme japonica (Thunb.) Diels 10 parts, Fructus Atriplicis Sibiricae 4 parts, Rhizoma Saururi (Herba Saururi) 13 parts, Cortex Eucommiae 6 parts, Buddleja asiatica 4 parts, Radix Saposhnikoviae 8 parts, Semen Celosiae 20 parts, Radix Sapii Discoloris 10 parts, Caulis Polygoni Multiflori 8 parts, Herba Scutellariae indicae 5 parts, Radix Gentianae 17 parts, Herba Artemisiae Scopariae 12 parts, Placenta Hominis 4 parts, Rhizoma Paridis 20 parts, Fructus Cnidii 10 parts, Radix Cynanchi Paniculati 12 parts, Herba Portulacae 2 parts, Herba Menthae 7 parts, Rhizoma Fagopyri Dibotryis 11 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Polygoni Cuspidati 3 parts, Folium Isatidis 13 parts, the Flos Sophorae Immaturus 3 parts, the Radix Astragali 3 parts, 5 parts, Radix Glycyrrhizae, Radix seu Caulis Verntilaginis Leiocarpae 9 parts, Herba Solani Lyrati 7 parts, Periostracum Cicadae 10 parts.

Further, crude drug composition and the parts by weight of making described Chinese medicine composition are: Herba Blumeae clarkei 5 parts, Coniogramme japonica (Thunb.) Diels 12 parts, Fructus Atriplicis Sibiricae 3 parts, Rhizoma Saururi (Herba Saururi) 12 parts, Cortex Eucommiae 9 parts, Buddleja asiatica 4 parts, Radix Saposhnikoviae 7 parts, Semen Celosiae 13 parts, Radix Sapii Discoloris 11 parts, Caulis Polygoni Multiflori 4 parts, Herba Scutellariae indicae 6 parts, Radix Gentianae 13 parts, Herba Artemisiae Scopariae 7 parts, Placenta Hominis 5 parts, Rhizoma Paridis 18 parts, Fructus Cnidii 11 parts, Radix Cynanchi Paniculati 9 parts, Herba Portulacae 4 parts, Herba Menthae 6 parts, Rhizoma Fagopyri Dibotryis 12 parts, Radix Angelicae Sinensis 13 parts, Rhizoma Polygoni Cuspidati 4 parts, Folium Isatidis 9 parts, the Flos Sophorae Immaturus 4 parts, the Radix Astragali 2 parts, 6 parts, Radix Glycyrrhizae, Radix seu Caulis Verntilaginis Leiocarpae 10 parts, Herba Solani Lyrati 5 parts, Periostracum Cicadae 12 parts.

Further, described Chinese medicine composition is prepared according to following method:

(1) pulverized by pulverizer after each crude drug of described components by weight percent proportionally being mixed, be ground into 100 order ~ 200 object powder, adding determining alcohol is 85% ~ 90% alcohol reflux 2.5 ~ 4 hours, the ethanol quality added is 3.5 ~ 5 times of mixture quality, filter, obtain filtering liquid medicine;

(2) medicinal liquid obtained for step (1) is passed through intermediate-polarity macroporous adsorption resin or low polar macroporous adsorption resin, first with water or concentration lower than 20% ethanol be colourless as elution to eluent, 1 ~ 1.5 times of the mixture quality that the water used or concentration obtain for step (1) lower than the quality of the ethanol of 20%, be the ethanol elution of 90% ~ 95% by concentration again, collect ethanol elution, the concentration used is 4 ~ 5 times of the mixture quality that the quality of the ethanol of 90% ~ 95% is step (1) Raw medicine, the pH value regulating ethanol elution with 0.5mol/L sodium hydroxide aqueous slkali is 6.5 ~ 7.5, place, filter, concentration and recovery ethanol, obtaining ethanol content is the solution of 10% ~ 15%, pass through polyamide resin column, first wash with water to eluent in closely colourless, 1.2 ~ 1.5 times of the mixture quality that the quality of the water used is step (1) Raw medicine, be the ethanol elution of 90% ~ 95% with determining alcohol again, collect ethanol elution, the concentration used is 1.3 ~ 1.5 times of the mixture quality that the quality of the ethanol of 90% ~ 95% is step (1) Raw medicine, reclaim ethanol, concentrated, drying under reduced pressure, obtain and get dry extract,

(3) dry cream obtained for step (2) is placed in super micron mill pulverizes 1.5-2 hour, pulverize, sieve, obtain 350-400 object micropowders;

(4) micropowders that step (3) is obtained is added appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule.

Further, described Chinese medicine composition is prepared according to following method:

(1) pulverized by pulverizer after each crude drug of described components by weight percent proportionally being mixed, be ground into 100 order ~ 200 object powder, adding determining alcohol is 85% ~ 90% alcohol reflux 2.5 ~ 4 hours, the ethanol quality added is 3.5 ~ 5 times of mixture quality, filter, obtain filtering liquid medicine;

(2) medicinal liquid obtained for step (1) is passed through intermediate-polarity macroporous adsorption resin or low polar macroporous adsorption resin, first with water or concentration lower than 20% ethanol be colourless as elution to eluent, 1 ~ 1.5 times of the mixture quality that the water used or concentration obtain for step (1) lower than the quality of the ethanol of 20%, be the ethanol elution of 90% ~ 95% by concentration again, collect ethanol elution, the concentration used is 4 ~ 5 times of the mixture quality that the quality of the ethanol of 90% ~ 95% is step (1) Raw medicine, the pH value regulating ethanol elution with 0.5mol/L sodium hydroxide aqueous slkali is 6.5 ~ 7.5, place, filter, concentration and recovery ethanol, obtaining ethanol content is the solution of 10% ~ 15%, pass through polyamide resin column, first wash with water to eluent in closely colourless, 1.2 ~ 1.5 times of the mixture quality that the quality of the water used is step (1) Raw medicine, be the ethanol elution of 90% ~ 95% with determining alcohol again, collect ethanol elution, the concentration used is 1.3 ~ 1.5 times of the mixture quality that the quality of the ethanol of 90% ~ 95% is step (1) Raw medicine, reclaim ethanol, concentrated, drying under reduced pressure, obtain and get dry extract,

(3) dry cream obtained for step (2) is placed in super micron mill pulverizes 1.5-2 hour, pulverize, sieve, obtain 350-400 object micropowders;

(4) micropowders that step (3) is obtained is added suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet.

Further, described Chinese medicine composition is prepared according to following method:

(1) pulverized by pulverizer after each crude drug of described components by weight percent proportionally being mixed, be ground into 100 order ~ 200 object powder, adding determining alcohol is 85% ~ 90% alcohol reflux 2.5 ~ 4 hours, the ethanol quality added is 3.5 ~ 5 times of mixture quality, filter, obtain filtering liquid medicine;

(2) medicinal liquid obtained for step (1) is passed through intermediate-polarity macroporous adsorption resin or low polar macroporous adsorption resin, first with water or concentration lower than 20% ethanol be colourless as elution to eluent, 1 ~ 1.5 times of the mixture quality that the water used or concentration obtain for step (1) lower than the quality of the ethanol of 20%, be the ethanol elution of 90% ~ 95% by concentration again, collect ethanol elution, the concentration used is 4 ~ 5 times of the mixture quality that the quality of the ethanol of 90% ~ 95% is step (1) Raw medicine, the pH value regulating ethanol elution with 0.5mol/L sodium hydroxide aqueous slkali is 6.5 ~ 7.5, place, filter, concentration and recovery ethanol, obtaining ethanol content is the solution of 10% ~ 15%, pass through polyamide resin column, first wash with water to eluent in closely colourless, 1.2 ~ 1.5 times of the mixture quality that the quality of the water used is step (1) Raw medicine, be the ethanol elution of 90% ~ 95% with determining alcohol again, collect ethanol elution, the concentration used is 1.3 ~ 1.5 times of the mixture quality that the quality of the ethanol of 90% ~ 95% is step (1) Raw medicine, reclaim ethanol, concentrated, drying under reduced pressure, obtain and get dry extract,

(3) dry cream obtained for step (2) is placed in super micron mill pulverizes 1.5-2 hour, pulverize, sieve, obtain 350-400 object micropowders;

(4), after the micropowders that step (3) is obtained being added suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, obtained granule.

The Chinese medicine composition that the invention still further relates to described treatment skin pruritus is after hemodialysis treating the application in skin pruritus disease drug after hemodialysis.

The Chinese medicine composition for the treatment of provided by the present invention skin pruritus after hemodialysis, it for raw material, gives full play to the property of medicine of each component with common Chinese herbal medicine:

Herba Blumeae clarkei: bitter in the mouth; Micro-pungent; Cool in nature; Clearing away heat to improve acuity of vision; Dispelling wind for relieving itching; Removing toxic substances and promoting subsidence of swelling.Main conjunctival congestion and swelling pain; Pterygium; Rubella; Scabies; Skin pruritus; Carbuncle furuncle; Traumatic injury is red and swollen.

Coniogramme japonica (Thunb.) Diels: another name Farfugium japonicum (L) Kitam.Liguaria Kaempferi Kino.; Pungent, sweet, micro-hardship, cool.Promoting blood circulation and hemostasis, mass dissipating and swelling eliminating.For spitting of blood of coughing, have blood in stool, menoxenia, traumatic injury, mastitis, carbuncle furuncle and phyma poison.

Fructus Atriplicis Sibiricae is the mature fruit of the annual or herbaceos perennial Fructus Tribuli Tribuluster-restrisL. of zygophyllaceae.Whole nation most area is all produced, but more with North of Yangtze River.Its bitter in the mouth, property are pungent, flat, enter Liver Channel.There is suppressing the hyperactive liver resolving depression, dispelling pathogenic wind for improving eyesight.For dizziness due to hyperactivity of liver-YANG headache, hypochondriac pain due to stagnation of liverQI, headache due to pathogenic wind-heat, conjunctival congestion and swelling pain, the diseases such as skin pruritus.Modern pharmacy research confirms, it is containing volatile oil, Saponin, fatty oil, Nitrates, resin, flavone compound and Alkaloid etc.Tribulus terrestris, has nature to promote testosterone, increases strength, improve overall competitive state, have no side effect.

Rhizoma Saururi (Herba Saururi): sweet, pungent, cold.There is inducing diuresis to remove edema, effect of heat-clearing and toxic substances removing.For edema, dysuria, drenches the puckery pain of drop, leukorrhagia; External treatment sore swollen toxin, eczema.

Cortex Eucommiae, Gan Weixin, temperature.Invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Control spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination is itched, vaginal bleeding during pregnancy for falling, frequent fetal movement, hypertension.

Buddleja asiatica: pungent, bitter, temperature.Slightly poisonous.Expelling wind and removing dampness, promoting flow of QI and blood.Have a pain for women's wind syndrome of head in puerperal pain, cold syndrome of the stomach, rheumatic arthritis, traumatic injury, fracture; Skin pruritus, eczema scrotum, innominate toxic swelling are controlled in external.

Radix Saposhnikoviae, nature and flavor: acrid in the mouth, sweet, slightly warm in nature, have effect that expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion are jerked surely, are used for the treatment of diseases caused by exogenous pathogenic factor exterior syndrome, rubella pruritus, rheumatic arthralgia, tetanus.

Semen Celosiae: bitter in the mouth, cold in nature; Return Liver Channel.To dispel people's heat, clearing away liver-fire, improving acuity of vision and removing nebula.Main conjunctival congestion and swelling pain, nebula of looking unfamiliar film, blurring of vision, hypertension, epistaxis, skin wind heat pruritus, skin ulcer tinea." property of medicine opinion " carries: " the dirty pyretic toxicity dotting punch for the treatment of the liver, red barrier, optic atrohic blindness, nebula are swollen.Main malignant boil scabies scabies, controls the inferior portion's worm dew skin ulcer.”

Radix Sapii Discoloris: bitter, cold, there is micro-poison.Diuretic relieving constipation, blood stasis removing is subsided a swelling.Control constipation, nebulousurine, traumatic injury, venom, hemorrhoid, skin pruritus.

Caulis Polygoni Multiflori: sweet in the mouth, property is put down, and GUIXIN, Liver Channel, have nourishing blood to tranquillize the mind, and effect of dispelling wind and removing obstruction in the collateral, cures mainly insomnia and dreamful sleep, blood deficiency general pain, rheumatic arthralgia; The cards such as skin pruritus, Caulis Polygoni Multiflori can be invigorated blood circulation, stimulate the menstrual flow, the detumescence of blood vessel dilating, blood circulation promoting, stimulating milk secretion.

Herba Scutellariae indicae: acrid in the mouth, hardship, cold in nature.GUIXIN, liver, lung meridian.For the herb of labiate Herba Scutellariae indicae.There is heat-clearing and toxic substances removing; Promoting blood circulation and stopping pain; Effect of hemostasia and detumescence.For carbuncle furunculosis; Lung abscess; Intestinal carbuncle; Scrofula; Venom; Lung-heat cough with asthma; Toothache; Sore throat; Pharyngalgia; Bones and muscles pain; Spit blood; Spitting of blood; Have blood in stool; Traumatic injury; Wound hemorrhage; Skin pruritus.

Radix Gentianae, bitter, cold.Return liver, gallbladder meridian.Be used as medicine part for gentianaceae plant Radix Gentianae, Gentiana manshurica, G. triflora and Yunnan Radix Gentianae, root welding technology.Heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire.For jaundice due to damp-heat, swelling of the vulva pudendal pruritus, leukorrhagia, persistent erection of the penis, eczema pruritus, conjunctival congestion, deaf, hypochondriac pain, bitter taste, convulsion with spasms." detailed outline ": treat throat pain, wind heat night sweat.Fire is posted in liver and gall mutually, have rush down of no help, therefore the gas of the liver benefiting gallbladder of Radix Gentianae, just with its can eliminating pathogen in the liver gallbladder pathogenic heat also.But in large bitter Great Cold, cross clothes and probably to injure one's stomach the gas of middle hair growth promoting, instead help pathogenic fire, also take Rhizoma Coptidis for a long time instead from the justice of cremate." book on Chinese herbal medicine is newly organized ": Radix Gentianae, its merit, specially in diuretic, disappears wet, and except jaundice, all the other are controlled order, dysentery relieving, detumescent, bring down a fever, and the speech of all popularizations also.But this kind too divides profit, rather consume gas deteriorated blood, water goes and blood also goes, wet disappearing and gas also disappears, from the beginning of water to wet jaundice, have to urgently with it, the water of prolonged illness wets jaundice, with must delay, just cannot not entirely rely on for diuretic god red, disappearing the wet miraculous cure removing illness also.Or meaning Radix Gentianae is controlled damp and hot, the most sharp illness is sick, just damp and hot disease also, so with Radix Gentianae with subcutaneous ulcer of harnessing the Yellow River, have not effect person, how also more? the real incessantly damp and hot one of jaundice also, have not hot and also become jaundice person, can control also by non-Radix Gentianae.Outstanding Radix Gentianae rushes down the heat in wetting, and can not rush down not hot wetting also.

Herba Artemisiae Scopariae: bitter in the mouth, pungent, cold nature.Return spleen, stomach, liver, gallbladder meridian.Function cures mainly: clearing away damp-heat, jaundice eliminating subcutaneous ulcer.For jaundice oliguria, eczema pruritus; Infectious jaundice type hepatitis." herbal classic ": the raw pathogenic heat gas of main air, accumulation of heat jaundice." not Lu ": control the whole body jaundice, dysuria, except feverish sensation in the head, removes mass in the large intestine.Supplement to the Herbal: get round by bribery, go stagnant heat, typhoid fever uses it." medical center bun is wanted ": hard kidney, dry spleen wets, and goes strongly fragrant, antipyretic." book on Chinese herbal medicine is new again ": pathogenic fire purging, suppressing the hyperactive liver, reduces phlegm, cough-relieving diaphoresis, dampness removing, detumescence, treats all poison of skin ulcer fire.

Placenta Hominis: sweet, salty, warm, mend, feel at ease to nourish blood, QI invigorating, benefit essence, removing toxic substances etc., cure mainly deficient, weakness and emaciation, hemoptysis asthma, consumptive fever hectic fever due to YIN-deficiency, seminal emission etc.

Rhizoma Paridis: cold nature, bitter in the mouth; Slightly poisonous.Enter Liver Channel.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain, cool liver arresting convulsion.Do in furuncle swell carbuncle, laryngopharynx swelling and pain, venom, fall and flutter the pain of injury, convulsion with spasms.Compendium of Material Medica is carried: " poison of snakeworm, namely what obtain that this controls stops, therefore has Rhizoma Paridis, stings not all names.Chong Tai, three layers, because it is also lobate.”

Fructus Cnidii is the fruit of samphire cnidium monnieri.Another name: Serpentis rice, Serpentis pearl, Serpentis foxtail millet, cnidium monnieri core, cnidium monnieri reality, gas fruit, Radix Habenariae Dentatae, favus-infected head beggar, wild Fructus Foeniculi.There is warming the kidney to invigorate YANG; Removing dampness and killing parasites; Effect of dispelling wind for relieving itching.Control impotence in male; Scrotum pruritus due to damp pathogen; Woman's infertility; Cold-damp leukorrhagia; Pudendal pruritus swells and ache; Rheumatic arthralgia; Eczema scabies.The Tang Dynasty be used for sexual impotence and cold womb infertile.Fructus Cnidii has the merit of warming the kidney to activate YANG, the impotence in male that treatment deficiency of kidney yin causes, and woman's cold womb is infertile, can be equal to use with Fructus Lycii, Semen Cuscutae, Fructus Schisandrae Chinensis, Cortex Cinnamomi, mends fire, supporing yang emerging flaccidity with kidney tonifying; " prescriptions worth thousand gold " controls kidney yang deficiency and coldness, and the Radix Aconiti ball that sexual impotence does not rise, namely forms with this product compatibility.For man's scrotum pruritus due to damp pathogen, woman's pudendal pruritus leukorrhagia, eczema scabies.Fructus Cnidii can dampness dispel the wind, killing parasites for relieving itching.Control eczema scrotum, woman's pudendal pruritus band is many, can be alone or decoct soup washout with Radix Sophorae Flavescentis, Cortex Phellodendri, Alumen etc.

Radix Cynanchi Paniculati, cures mainly: analgesia, cough-relieving, inducing diuresis to remove edema, promoting blood circulation and detoxication.Treat for stomachache, toothache, rheumatalgia, abdominal pain in menstruation, chronic tracheitis, ascites, edema, dysentery, enteritis, traumatic injury, eczema, urticaria, venom.1, for various pain diseases such as rheumatic arthralgia, lumbago, traumatic injury pain, abdominal pain, toothache.Radix Cynanchi Paniculati has good wind-expelling pain-stopping effect, is widely used for the various pain diseases caused by rheumatism, cold coagulation, the stagnation of QI, blood stasis.In recent years also for postoperative pain and cancerous protuberance pain, there is certain analgesic effect.Can apply by single, or with demonstrate,proving the relevant medicine of compatibility.2, by dermatosiss such as eczema, rubella wheal, stubborn dermatitis.This product has dispelling wind for relieving itching effect.Can be alone for oral administration or decoct soup washout, also can the medicine of the eliminating damp-heat such as compatibility Radix Sophorae Flavescentis, the Fructus Kochiae, Cortex Dictamni.In addition, this product can also antidote against snake bite, and controls venom.Can with Herba Lobeliae Chinensis with using for oral administration or external.

Herba Portulacae: cold in nature, sweet in the mouth, acid; Enter the heart, liver, spleen, large intestine channel.Removing dampness is antipruritic, heat-clearing and toxic substances removing, and diuretic dries, loose blood detumescence, dust-collection sterilization, anti-inflammatory analgetic.Modern medicine study confirms, Herba Portulacae has stronger inhibitory action to dysentery bacterium, Bacillus typhi and escherichia coli, can be used for the auxiliary treatment of various inflammation, have the title of " natural antibiotics ".

Herba Menthae: acrid in the mouth, cool in nature.Return lung, Liver Channel, have and disperse wind heat, clearing throat, rash is detoxified, dispersing the stagnated live-QI to relieve the stagnation of QI and the effect such as antipruritic, be applicable to the disease such as cold, fever, headache, laryngopharynx swelling and pain, lossless, wind-fire acute conjunctivitis, rubella, skin are itched, colic, dysentery and scrofula, external has slight analgesic effect, for neuralgia etc.

Rhizoma Fagopyri Dibotryis: cool in nature, acrid in the mouth, hardship.Energy heat-clearing and toxic substances removing, eliminating carbuncle of invigorating blood circulation, expelling wind and removing dampness sore, snake bite and insect sting.Main lung abscess, lung-heat cough with asthma, laryngopharynx swelling and pain, dysentery, rheumatism arthromyodynia, traumatic injury, carbuncle cancer.

Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelicasinensis (Oliv.) Diels.Meridian distribution of property and flavor is warm in nature, hides sweet, pungent.Return liver, the heart, spleen channel.Function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.

Rhizoma Polygoni Cuspidati: dispel the wind, dampness removing, removing blood stasis with potent drugs, stimulates the menstrual flow.Dispelling the wind and dampness pathogens bones and muscles pain, jaundice due to damp-heat, stranguria with turbid discharge leukorrhagia, women's amenorrhea, lochiostasis, lump in the abdomen, anal fistula hematochezia.Injury from falling down, scalds, malignant boil tinea disease.Arrhythmia and anti-cardiac muscle are lost blood blood circulation promoting and blood stasis dispelling.

Folium Isatidis: bitter in the mouth, cold in nature.Return liver, the heart, stomach, spleen channel.Heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.For the high hot excessive thirst of calentura; Coma; Macule; Spit blood; Epistaxis; Jaundice; Dysentery; Erysipelas; Sore throat; Aphtha; Mumps.

The Flos Sophorae Immaturus: bitter in the mouth, cold nature, enters liver, lung, the heart, large intestine channel.Cooling blood for hemostasis, liver heat removing and eyesight improving.Cure mainly discharging fresh blood stool, hemorrhoid hematochezia, dysentery, hematuria, stranguria with blood, metrorrhagia, spit blood, epistaxis, liver-heat is had a headache, conjunctival congestion and swelling pain, carbuncle skin infection." book on Chinese herbal medicine just " carries: " cool large intestine kills infantile malnutrition worm.Control skin sore, erosion of vulva pruritus due to damp pathogen, anal fistula, separate Fructus Myricae rubrae malignant boil, primary sore volt poison." modern medicine study confirms, the globulariacitrin contained by the Flos Sophorae Immaturus can strengthen capillary resistance, improves blood vessel wall fragility, has blood pressure lowering, edema, prevents effect of rupture of blood vessel in brain, also have antiinflammatory action in addition.

The Radix Astragali: sweet in the mouth, warm in nature, return lung, spleen channel.Invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.Modern medicine study confirms, the Radix Astragali can be strengthened normal heart and shrink, and has cardiotonic to the heart of exhaustion.

Radix seu Caulis Verntilaginis Leiocarpae, sweet; Temperature.Return lung, spleen channel.Function cures mainly: fill blood; Bone and muscle strengthening; Relax meridians.Main deficient qi and blood; Have through uncomfortable; Blood deficiency amenorrhea; Rheumatalgia; Traumatic injury; Lumbar muscle strain.

Herba Solani Lyrati: sweet in the mouth, hardship, cold in nature; Return liver, gallbladder, kidney channel.Clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Main jaundice due to damp-heat, cholecystitis, cholelithiasis, oedema due to nephritis, rheumatic arthritis, women's damp-heat vaginal discharge, infantile hyperpyrexia is frightened jerks, carbuncle scrofula, eczema pruritus, herpes zoster.Modern medicine study confirms, Herba Solani Lyrati and Fructus Jujubae are mixed and made into decoct with 1:1, syrup has inhibitory action to the solid type of the empty ehrlich ascites carcinoma of white mice Ai Li and spindle cell sarcoma and ascitic type.

Periostracum Cicadae: sweet in the mouth; Salty; Cool in nature.Enter lung; Liver Channel.Dispelling wind-heat; Rash sore-throat relieving; Removing nebula to improve visual acuity; Expelling wind and relieving convulsion.Cure mainly anemopyretic cold; Laryngopharynx swelling and pain; Cough hoarseness; Stupid rash is not saturating; Rubella pruritus; Cataract; Infantile convulsion is twitched; Tetanus." detailed outline " carries: " control phlegm-accumulating vertigo, skin wind heat, varioliform exanthema is had an itch, tetanus and treatment toxic swelling tumor, and adult's aphonia, children's's lockjaw sky hangs, frightened night cry of crying, swelling of the vulva." modern medicine study confirmation; Periostracum Cicadae has obvious convulsion, sedation, can block parasympathetic conduction on neck, is widely used in treatment tetanus, chronic Herba Urticae Cannabinae is examined, suppurative otitis media, vasodilation; also have cough-relieving to cough in addition, the particularly effect coughed of itching of the throat.

Radix Glycyrrhizae: sweet in the mouth, property is put down, GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Pharmacological evaluation surface, Radix Glycyrrhizae has the effect of anti-liver injury, and can strengthen adrenergic cardiotonic.

" itch next from wind " from motherland's medical angle, Skin Itch in Uremia Patients take wind syndrome due to blood-deficiency as this, and noxious dampness is strongly fragrant in space between skin and muscles, and skin loses supports as mark in moistening, and with heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, liver and kidney tonifying, dispelling wind for relieving itching is the rule for the treatment of.The all medicine compatibilities of this Chinese medicine composition, have effect of nourishing blood and promoting blood circulation, heat-clearing and toxic substances removing, dispelling wind for relieving itching, and remarkable for the pruritus therapeutic effect occurred after Rend dialysis, safe without toxic side effect, can significantly improve Rend dialysis patients ' life quality.

Detailed description of the invention:

For making the object of the embodiment of the present invention, technical scheme and advantage clearly, below in conjunction with embodiment, technical scheme of the present invention is clearly and completely described.Obviously, described embodiment is a part of the present invention, instead of whole embodiments.Based on described embodiments of the invention, the every other embodiment that those of ordinary skill in the art obtain under without the need to the prerequisite of creative work, all belongs to the scope of protection of the invention.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume.

Embodiment 1:

A kind of Chinese medicine composition for the treatment of skin pruritus after hemodialysis of the present invention, comprise the raw material of Chinese medicine medicine of following weight: Herba Blumeae clarkei 6 grams, Coniogramme japonica (Thunb.) Diels 8 grams, Fructus Atriplicis Sibiricae 3 grams, Rhizoma Saururi (Herba Saururi) 15 grams, Cortex Eucommiae 5 grams, Buddleja asiatica 3 grams, Radix Saposhnikoviae 5 grams, Semen Celosiae 12 grams, Radix Sapii Discoloris 16 grams, Caulis Polygoni Multiflori 3 grams, Herba Scutellariae indicae 12 grams, Radix Gentianae 12 grams, Herba Artemisiae Scopariae 10 grams, Placenta Hominis 9 grams, Rhizoma Paridis 15 grams, Fructus Cnidii 15 grams, Radix Cynanchi Paniculati 8 grams, Herba Portulacae 5 grams, Herba Menthae 3 grams, Rhizoma Fagopyri Dibotryis 14 grams, Radix Angelicae Sinensis 9 grams, Rhizoma Polygoni Cuspidati 6 grams, Folium Isatidis 8 grams, the Flos Sophorae Immaturus 5 grams, the Radix Astragali 1 gram, 10 grams, Radix Glycyrrhizae, Radix seu Caulis Verntilaginis Leiocarpae 15 grams, Herba Solani Lyrati 3 grams, Periostracum Cicadae 8 grams.

Described Chinese medicine composition is prepared according to following method:

(1) pulverized by pulverizer after each crude drug of described components by weight percent proportionally being mixed, be ground into 100 order ~ 200 object powder, adding determining alcohol is 85% ~ 90% alcohol reflux 2.5 ~ 4 hours, the ethanol quality added is 3.5 ~ 5 times of mixture quality, filter, obtain filtering liquid medicine;

(2) medicinal liquid obtained for step (1) is passed through intermediate-polarity macroporous adsorption resin or low polar macroporous adsorption resin, first with water or concentration lower than 20% ethanol be colourless as elution to eluent, 1 ~ 1.5 times of the mixture quality that the water used or concentration obtain for step (1) lower than the quality of the ethanol of 20%, be the ethanol elution of 90% ~ 95% by concentration again, collect ethanol elution, the concentration used is 4 ~ 5 times of the mixture quality that the quality of the ethanol of 90% ~ 95% is step (1) Raw medicine, the pH value regulating ethanol elution with 0.5mol/L sodium hydroxide aqueous slkali is 6.5 ~ 7.5, place, filter, concentration and recovery ethanol, obtaining ethanol content is the solution of 10% ~ 15%, pass through polyamide resin column, first wash with water to eluent in closely colourless, 1.2 ~ 1.5 times of the mixture quality that the quality of the water used is step (1) Raw medicine, be the ethanol elution of 90% ~ 95% with determining alcohol again, collect ethanol elution, the concentration used is 1.3 ~ 1.5 times of the mixture quality that the quality of the ethanol of 90% ~ 95% is step (1) Raw medicine, reclaim ethanol, concentrated, drying under reduced pressure, obtain and get dry extract,

(3) dry cream obtained for step (2) is placed in super micron mill pulverizes 1.5-2 hour, pulverize, sieve, obtain 350-400 object micropowders;

(4) micropowders that step (3) is obtained is added appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule.

Embodiment 2:

A kind of Chinese medicine composition for the treatment of skin pruritus after hemodialysis of the present invention, comprise the raw material of Chinese medicine medicine of following weight: Herba Blumeae clarkei 4 grams, Coniogramme japonica (Thunb.) Diels 10 grams, Fructus Atriplicis Sibiricae 4 grams, Rhizoma Saururi (Herba Saururi) 13 grams, Cortex Eucommiae 6 grams, Buddleja asiatica 4 grams, Radix Saposhnikoviae 8 grams, Semen Celosiae 20 grams, Radix Sapii Discoloris 10 grams, Caulis Polygoni Multiflori 8 grams, Herba Scutellariae indicae 5 grams, Radix Gentianae 17 grams, Herba Artemisiae Scopariae 12 grams, Placenta Hominis 4 grams, Rhizoma Paridis 20 grams, Fructus Cnidii 10 grams, Radix Cynanchi Paniculati 12 grams, Herba Portulacae 2 grams, Herba Menthae 7 grams, Rhizoma Fagopyri Dibotryis 11 grams, Radix Angelicae Sinensis 15 grams, Rhizoma Polygoni Cuspidati 3 grams, Folium Isatidis 13 grams, the Flos Sophorae Immaturus 3 grams, the Radix Astragali 3 grams, 5 grams, Radix Glycyrrhizae, Radix seu Caulis Verntilaginis Leiocarpae 9 grams, Herba Solani Lyrati 7 grams, Periostracum Cicadae 10 grams.

Described Chinese medicine composition is prepared according to following method:

(1) pulverized by pulverizer after each crude drug of described components by weight percent proportionally being mixed, be ground into 100 order ~ 200 object powder, adding determining alcohol is 85% ~ 90% alcohol reflux 2.5 ~ 4 hours, the ethanol quality added is 3.5 ~ 5 times of mixture quality, filter, obtain filtering liquid medicine;

(2) medicinal liquid obtained for step (1) is passed through intermediate-polarity macroporous adsorption resin or low polar macroporous adsorption resin, first with water or concentration lower than 20% ethanol be colourless as elution to eluent, 1 ~ 1.5 times of the mixture quality that the water used or concentration obtain for step (1) lower than the quality of the ethanol of 20%, be the ethanol elution of 90% ~ 95% by concentration again, collect ethanol elution, the concentration used is 4 ~ 5 times of the mixture quality that the quality of the ethanol of 90% ~ 95% is step (1) Raw medicine, the pH value regulating ethanol elution with 0.5mol/L sodium hydroxide aqueous slkali is 6.5 ~ 7.5, place, filter, concentration and recovery ethanol, obtaining ethanol content is the solution of 10% ~ 15%, pass through polyamide resin column, first wash with water to eluent in closely colourless, 1.2 ~ 1.5 times of the mixture quality that the quality of the water used is step (1) Raw medicine, be the ethanol elution of 90% ~ 95% with determining alcohol again, collect ethanol elution, the concentration used is 1.3 ~ 1.5 times of the mixture quality that the quality of the ethanol of 90% ~ 95% is step (1) Raw medicine, reclaim ethanol, concentrated, drying under reduced pressure, obtain and get dry extract,

(3) dry cream obtained for step (2) is placed in super micron mill pulverizes 1.5-2 hour, pulverize, sieve, obtain 350-400 object micropowders;

(4) micropowders that step (3) is obtained is added suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet.

Embodiment 3:

A kind of Chinese medicine composition for the treatment of skin pruritus after hemodialysis of the present invention, comprise the raw material of Chinese medicine medicine of following weight: Herba Blumeae clarkei 5 grams, Coniogramme japonica (Thunb.) Diels 12 grams, Fructus Atriplicis Sibiricae 3 grams, Rhizoma Saururi (Herba Saururi) 12 grams, Cortex Eucommiae 9 grams, Buddleja asiatica 4 grams, Radix Saposhnikoviae 7 grams, Semen Celosiae 13 grams, Radix Sapii Discoloris 11 grams, Caulis Polygoni Multiflori 4 grams, Herba Scutellariae indicae 6 grams, Radix Gentianae 13 grams, Herba Artemisiae Scopariae 7 grams, Placenta Hominis 5 grams, Rhizoma Paridis 18 grams, Fructus Cnidii 11 grams, Radix Cynanchi Paniculati 9 grams, Herba Portulacae 4 grams, Herba Menthae 6 grams, Rhizoma Fagopyri Dibotryis 12 grams, Radix Angelicae Sinensis 13 grams, Rhizoma Polygoni Cuspidati 4 grams, Folium Isatidis 9 grams, the Flos Sophorae Immaturus 4 grams, the Radix Astragali 2 grams, 6 grams, Radix Glycyrrhizae, Radix seu Caulis Verntilaginis Leiocarpae 10 grams, Herba Solani Lyrati 5 grams, Periostracum Cicadae 12 grams.

Described Chinese medicine composition is prepared according to following method:

(1) pulverized by pulverizer after each crude drug of described components by weight percent proportionally being mixed, be ground into 100 order ~ 200 object powder, adding determining alcohol is 85% ~ 90% alcohol reflux 2.5 ~ 4 hours, the ethanol quality added is 3.5 ~ 5 times of mixture quality, filter, obtain filtering liquid medicine;

(2) medicinal liquid obtained for step (1) is passed through intermediate-polarity macroporous adsorption resin or low polar macroporous adsorption resin, first with water or concentration lower than 20% ethanol be colourless as elution to eluent, 1 ~ 1.5 times of the mixture quality that the water used or concentration obtain for step (1) lower than the quality of the ethanol of 20%, be the ethanol elution of 90% ~ 95% by concentration again, collect ethanol elution, the concentration used is 4 ~ 5 times of the mixture quality that the quality of the ethanol of 90% ~ 95% is step (1) Raw medicine, the pH value regulating ethanol elution with 0.5mol/L sodium hydroxide aqueous slkali is 6.5 ~ 7.5, place, filter, concentration and recovery ethanol, obtaining ethanol content is the solution of 10% ~ 15%, pass through polyamide resin column, first wash with water to eluent in closely colourless, 1.2 ~ 1.5 times of the mixture quality that the quality of the water used is step (1) Raw medicine, be the ethanol elution of 90% ~ 95% with determining alcohol again, collect ethanol elution, the concentration used is 1.3 ~ 1.5 times of the mixture quality that the quality of the ethanol of 90% ~ 95% is step (1) Raw medicine, reclaim ethanol, concentrated, drying under reduced pressure, obtain and get dry extract,

(3) dry cream obtained for step (2) is placed in super micron mill pulverizes 1.5-2 hour, pulverize, sieve, obtain 350-400 object micropowders;

(4), after the micropowders that step (3) is obtained being added suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, obtained granule.

Toxicity test:

Application NIH mice 60, SPF level, male and female half and half, body weight 18 ~ 22g, carries out acute toxicity testing.Mice is divided into two groups at random, i.e. matched group and administration group, fasting 12 hours before experiment, Chinese medicine composition tablet prepared by embodiments of the invention 2 is dissolved in water, (concentration is 6.28g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 31.4g crude drug/kg), matched group gives normal saline, administration in 1 day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice, specifically refer to table 1.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, experiment Continuous Observation 14 days, mouse systemic situation, ingest, drink water, body weight increases all normal.Mouse oral gavage capsule LD of the present invention ₅₀> 31.4g crude drug/kg, every day, maximum dosage-feeding was 62.8g crude drug/kg/ day.Chinese medicine composition clinical application amount of the present invention be 2.1g crude drug/day/people, adult body weight in 60kg, average dosage is 0.035g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 20g) oral administration gavage Chinese medicine composition of the present invention is 897 times of quantity.Therefore Chinese medicine composition acute toxicity of the present invention is low, clinical drug safety.

Clinical reasoning:

In April ,-2015 in January, 2014, Maintenance Hemodialysis Patients 88 example is randomly drawed in outpatient service place, all has refractory pruritus and xerosis cutis in various degree, desquamation, erythra etc., companion hypertension, anemia and electrolyte disturbance in various degree.Be divided into two groups at random, treatment group 44 example, man 22 example, female 22 example; Age 25-78 year, average (47.1 ± 14.3) year, protopathy comprises chronic glomerulonephritis 19 example, diabetic nephropathy 7 example, hypertensive renal damage 6 example, lupus nephritis 4 example, Adult Polycystic Kidney 8 example, average dialysis 3 years.Light-duty 24 examples of skin pruritus, medium-sized 13 examples, heavy 7 examples; The skin pruritus course of disease is the shortest 1.3 months, the longest 7 months, average 2.9 months.Matched group 44 example, man 23 example, female 21 example; Age 22-79 year, average (46.2 ± 15.7) year.Protopathy comprises chronic glomerulonephritis 20 example, diabetic nephropathy 6 example, hypertensive cerebral renal damage 8 example, lupus nephritis 4 example, Adult Polycystic Kidney 4 example, drug-induced renal impairment: 2 example.Light-duty 25 examples of skin pruritus, medium-sized 11 examples, heavy 8 examples; The skin pruritus course of disease is the shortest 1.3 months, the longest 5.4 months, average 2.8 months.

Diagnostic criteria:

Selection meets following condition:

1. the diagnostic criteria of chronic renal failure in " nephrology " is met and the patient of serum creatinine > 700I μm of ol/L maintenance conventional hemodialysis (CHD);

2. " modern dermatological " skin pruritus diagnostic criteria is met: have skin pruritus, but without the dermatosis of former skin lesion;

3. skin pruritus caused by other reasons is got rid of and eliminating is associated with serious cardio cerebrovascular affection person.

Therapeutic Method:

Treatment group: patient takes the tablet of the embodiment of the present invention 2, sooner or later take at twice, each 2 10 days is 1 course for the treatment of, treats 2-3 the course for the treatment of altogether.

Matched group: patient gives 1% Calamine Lotion, every day is coated with skin outward 2-3 time, within 10 days, is 1 course for the treatment of, treats 2-3 the course for the treatment of altogether.

Curative effect determinate standard

Cure: pruritis disappears, and Secondary cases skin lesion disappears;

Effective: pruritis obviously alleviates, Secondary cases skin lesion disappears 80%;

Take a turn for the better: pruritis alleviates, and Secondary cases skin lesion disappears about 50%;

Invalid: pruritis is without alleviating or increasing the weight of, and Secondary cases skin lesion disappears < 50%.

Result

Clinical efficacy comparison, the results are shown in Table 1.

Table 1 liang group patient effective percentage relative analysis

Group

Number of cases

Cure

Effective

Take a turn for the better

Invalid

Effectively total

Treatment group

44

27(61.4％)

11(25％)

5(11.4％)

1(2.3％)

43(97.7％)

Matched group

44

14(31.8％)

11(25％)

6(13.6％)

13(29.5％)

31(70.5％)

Wherein, total effective rate=cure rate+obvious effective rate.

Table 1 result shows: tablet total effective rate prepared by the embodiment of the present invention 2 is 97.7%; matched group total effective rate 70.5%; result shows, illustrates that medicine of the present invention achieves better therapeutic effect than traditional therapy in curative effect, is suitable for scale clinical practice.

Model case:

Case 1

Zhao, man, 62 years old, Qingdao City Laoshan District people, uremic patient, after repeatedly carrying out Rend dialysis, there is skin pruritus, cause skin lesion, take the tablet of the embodiment of the present invention 2, one day twice, each two panels, sooner or later one after each meal, within 10 days, be a course for the treatment of, after using 2 courses for the treatment of, pruritis alleviates, skin lesion disappears 50%, and continue between dialysis period to take, during Rend dialysis, above-mentioned symptom is without recurrence.

Case 2

Money, man, 35 years old, Qingdao Jimo people, uremic patient, after carrying out Rend dialysis, there is skin pruritus, cause skin lesion, take the capsule of the embodiment of the present invention 1, one day twice, each two, one after each meal sooner or later, within 10 days, be a course for the treatment of, after 1 course for the treatment of, pruritis alleviates, skin lesion disappears 80%, and continue between dialysis period to take, during Rend dialysis, above-mentioned symptom is without recurrence.

Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the scope of various embodiments of the present invention technical scheme.

Claims (9)

1. treat a Chinese medicine composition for skin pruritus after hemodialysis, it is characterized in that: the crude drug of described Chinese medicine composition is made up of Herba Blumeae clarkei, Coniogramme japonica (Thunb.) Diels, Fructus Atriplicis Sibiricae, Rhizoma Saururi (Herba Saururi), Cortex Eucommiae, Buddleja asiatica, Radix Saposhnikoviae, Semen Celosiae, Radix Sapii Discoloris, Caulis Polygoni Multiflori, Herba Scutellariae indicae, Radix Gentianae, Herba Artemisiae Scopariae, Placenta Hominis, Rhizoma Paridis, Fructus Cnidii, Radix Cynanchi Paniculati, Herba Portulacae, Herba Menthae, Rhizoma Fagopyri Dibotryis, Radix Angelicae Sinensis, Rhizoma Polygoni Cuspidati, Folium Isatidis, the Flos Sophorae Immaturus, the Radix Astragali, Radix seu Caulis Verntilaginis Leiocarpae, Herba Solani Lyrati, Periostracum Cicadae, Radix Glycyrrhizae.

2. the Chinese medicine composition for the treatment of according to claim 1 skin pruritus after hemodialysis, it is characterized in that: crude drug composition and the parts by weight of making described Chinese medicine composition are: Herba Blumeae clarkei 4-6 part, Coniogramme japonica (Thunb.) Diels 8-12 part, Fructus Atriplicis Sibiricae 3-4 part, Rhizoma Saururi (Herba Saururi) 12-15 part, Cortex Eucommiae 5-9 part, Buddleja asiatica 3-4 part, Radix Saposhnikoviae 5-8 part, Semen Celosiae 12-20 part, Radix Sapii Discoloris 10-16 part, Caulis Polygoni Multiflori 3-8 part, Herba Scutellariae indicae 5-12 part, Radix Gentianae 12-17 part, Herba Artemisiae Scopariae 7-12 part, Placenta Hominis 4-9 part, Rhizoma Paridis 15-20 part, Fructus Cnidii 10-15 part, Radix Cynanchi Paniculati 8-12 part, Herba Portulacae 2-5 part, Herba Menthae 3-7 part, Rhizoma Fagopyri Dibotryis 11-14 part, Radix Angelicae Sinensis 9-15 part, Rhizoma Polygoni Cuspidati 3-6 part, Folium Isatidis 8-13 part, Flos Sophorae Immaturus 3-5 part, Radix Astragali 1-3 part, Radix Glycyrrhizae 5-10 part, Radix seu Caulis Verntilaginis Leiocarpae 9-15 part, Herba Solani Lyrati 3-7 part, Periostracum Cicadae 8-12 part.

3. the Chinese medicine composition for the treatment of according to claim 2 skin pruritus after hemodialysis, it is characterized in that, crude drug composition and the parts by weight of making described Chinese medicine composition are: Herba Blumeae clarkei 6 parts, Coniogramme japonica (Thunb.) Diels 8 parts, Fructus Atriplicis Sibiricae 3 parts, Rhizoma Saururi (Herba Saururi) 15 parts, Cortex Eucommiae 5 parts, Buddleja asiatica 3 parts, Radix Saposhnikoviae 5 parts, Semen Celosiae 12 parts, Radix Sapii Discoloris 16 parts, Caulis Polygoni Multiflori 3 parts, Herba Scutellariae indicae 12 parts, Radix Gentianae 12 parts, Herba Artemisiae Scopariae 10 parts, Placenta Hominis 9 parts, Rhizoma Paridis 15 parts, Fructus Cnidii 15 parts, Radix Cynanchi Paniculati 8 parts, Herba Portulacae 5 parts, Herba Menthae 3 parts, Rhizoma Fagopyri Dibotryis 14 parts, Radix Angelicae Sinensis 9 parts, Rhizoma Polygoni Cuspidati 6 parts, Folium Isatidis 8 parts, the Flos Sophorae Immaturus 5 parts, the Radix Astragali 1 part, 10 parts, Radix Glycyrrhizae, Radix seu Caulis Verntilaginis Leiocarpae 15 parts, Herba Solani Lyrati 3 parts, Periostracum Cicadae 8 parts.

4. the Chinese medicine composition for the treatment of according to claim 2 skin pruritus after hemodialysis, it is characterized in that, crude drug composition and the parts by weight of making described Chinese medicine composition are: Herba Blumeae clarkei 4 parts, Coniogramme japonica (Thunb.) Diels 10 parts, Fructus Atriplicis Sibiricae 4 parts, Rhizoma Saururi (Herba Saururi) 13 parts, Cortex Eucommiae 6 parts, Buddleja asiatica 4 parts, Radix Saposhnikoviae 8 parts, Semen Celosiae 20 parts, Radix Sapii Discoloris 10 parts, Caulis Polygoni Multiflori 8 parts, Herba Scutellariae indicae 5 parts, Radix Gentianae 17 parts, Herba Artemisiae Scopariae 12 parts, Placenta Hominis 4 parts, Rhizoma Paridis 20 parts, Fructus Cnidii 10 parts, Radix Cynanchi Paniculati 12 parts, Herba Portulacae 2 parts, Herba Menthae 7 parts, Rhizoma Fagopyri Dibotryis 11 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Polygoni Cuspidati 3 parts, Folium Isatidis 13 parts, the Flos Sophorae Immaturus 3 parts, the Radix Astragali 3 parts, 5 parts, Radix Glycyrrhizae, Radix seu Caulis Verntilaginis Leiocarpae 9 parts, Herba Solani Lyrati 7 parts, Periostracum Cicadae 10 parts.

5. the Chinese medicine composition for the treatment of according to claim 2 skin pruritus after hemodialysis, it is characterized in that, crude drug composition and the parts by weight of making described Chinese medicine composition are: Herba Blumeae clarkei 5 parts, Coniogramme japonica (Thunb.) Diels 12 parts, Fructus Atriplicis Sibiricae 3 parts, Rhizoma Saururi (Herba Saururi) 12 parts, Cortex Eucommiae 9 parts, Buddleja asiatica 4 parts, Radix Saposhnikoviae 7 parts, Semen Celosiae 13 parts, Radix Sapii Discoloris 11 parts, Caulis Polygoni Multiflori 4 parts, Herba Scutellariae indicae 6 parts, Radix Gentianae 13 parts, Herba Artemisiae Scopariae 7 parts, Placenta Hominis 5 parts, Rhizoma Paridis 18 parts, Fructus Cnidii 11 parts, Radix Cynanchi Paniculati 9 parts, Herba Portulacae 4 parts, Herba Menthae 6 parts, Rhizoma Fagopyri Dibotryis 12 parts, Radix Angelicae Sinensis 13 parts, Rhizoma Polygoni Cuspidati 4 parts, Folium Isatidis 9 parts, the Flos Sophorae Immaturus 4 parts, the Radix Astragali 2 parts, 6 parts, Radix Glycyrrhizae, Radix seu Caulis Verntilaginis Leiocarpae 10 parts, Herba Solani Lyrati 5 parts, Periostracum Cicadae 12 parts.

6., according to the Chinese medicine composition of the arbitrary described treatment of claim 3-5 skin pruritus after hemodialysis, it is characterized in that: described Chinese medicine composition is prepared according to following method:

(1) pulverized by pulverizer after each crude drug of described components by weight percent proportionally being mixed, be ground into 100 order ~ 200 object powder, adding determining alcohol is 85% ~ 90% alcohol reflux 2.5 ~ 4 hours, the ethanol quality added is 3.5 ~ 5 times of mixture quality, filter, obtain filtering liquid medicine;

(2) medicinal liquid obtained for step (1) is passed through intermediate-polarity macroporous adsorption resin or low polar macroporous adsorption resin, first with water or concentration lower than 20% ethanol be colourless as elution to eluent, 1 ~ 1.5 times of the mixture quality that the water used or concentration obtain for step (1) lower than the quality of the ethanol of 20%, be the ethanol elution of 90% ~ 95% by concentration again, collect ethanol elution, the concentration used is 4 ~ 5 times of the mixture quality that the quality of the ethanol of 90% ~ 95% is step (1) Raw medicine, the pH value regulating ethanol elution with 0.5mol/L sodium hydroxide aqueous slkali is 6.5 ~ 7.5, place, filter, concentration and recovery ethanol, obtaining ethanol content is the solution of 10% ~ 15%, pass through polyamide resin column, first wash with water to eluent in closely colourless, 1.2 ~ 1.5 times of the mixture quality that the quality of the water used is step (1) Raw medicine, be the ethanol elution of 90% ~ 95% with determining alcohol again, collect ethanol elution, the concentration used is 1.3 ~ 1.5 times of the mixture quality that the quality of the ethanol of 90% ~ 95% is step (1) Raw medicine, reclaim ethanol, concentrated, drying under reduced pressure, obtain and get dry extract,

(3) dry cream obtained for step (2) is placed in super micron mill pulverizes 1.5-2 hour, pulverize, sieve, obtain 350-400 object micropowders;

(4) micropowders that step (3) is obtained is added appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule.

7., according to the Chinese medicine composition of the arbitrary described treatment of claim 3-5 skin pruritus after hemodialysis, it is characterized in that: described Chinese medicine composition is prepared according to following method:

(1) pulverized by pulverizer after each crude drug of described components by weight percent proportionally being mixed, be ground into 100 order ~ 200 object powder, adding determining alcohol is 85% ~ 90% alcohol reflux 2.5 ~ 4 hours, the ethanol quality added is 3.5 ~ 5 times of mixture quality, filter, obtain filtering liquid medicine;

(2) medicinal liquid obtained for step (1) is passed through intermediate-polarity macroporous adsorption resin or low polar macroporous adsorption resin, first with water or concentration lower than 20% ethanol be colourless as elution to eluent, 1 ~ 1.5 times of the mixture quality that the water used or concentration obtain for step (1) lower than the quality of the ethanol of 20%, be the ethanol elution of 90% ~ 95% by concentration again, collect ethanol elution, the concentration used is 4 ~ 5 times of the mixture quality that the quality of the ethanol of 90% ~ 95% is step (1) Raw medicine, the pH value regulating ethanol elution with 0.5mol/L sodium hydroxide aqueous slkali is 6.5 ~ 7.5, place, filter, concentration and recovery ethanol, obtaining ethanol content is the solution of 10% ~ 15%, pass through polyamide resin column, first wash with water to eluent in closely colourless, 1.2 ~ 1.5 times of the mixture quality that the quality of the water used is step (1) Raw medicine, be the ethanol elution of 90% ~ 95% with determining alcohol again, collect ethanol elution, the concentration used is 1.3 ~ 1.5 times of the mixture quality that the quality of the ethanol of 90% ~ 95% is step (1) Raw medicine, reclaim ethanol, concentrated, drying under reduced pressure, obtain and get dry extract,

(3) dry cream obtained for step (2) is placed in super micron mill pulverizes 1.5-2 hour, pulverize, sieve, obtain 350-400 object micropowders;

(4) micropowders that step (3) is obtained is added suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet.

8., according to the Chinese medicine composition of the arbitrary described treatment of claim 3-5 skin pruritus after hemodialysis, it is characterized in that: described Chinese medicine composition is prepared according to following method:

(1) pulverized by pulverizer after each crude drug of described components by weight percent proportionally being mixed, be ground into 100 order ~ 200 object powder, adding determining alcohol is 85% ~ 90% alcohol reflux 2.5 ~ 4 hours, the ethanol quality added is 3.5 ~ 5 times of mixture quality, filter, obtain filtering liquid medicine;

(2) medicinal liquid obtained for step (1) is passed through intermediate-polarity macroporous adsorption resin or low polar macroporous adsorption resin, first with water or concentration lower than 20% ethanol be colourless as elution to eluent, 1 ~ 1.5 times of the mixture quality that the water used or concentration obtain for step (1) lower than the quality of the ethanol of 20%, be the ethanol elution of 90% ~ 95% by concentration again, collect ethanol elution, the concentration used is 4 ~ 5 times of the mixture quality that the quality of the ethanol of 90% ~ 95% is step (1) Raw medicine, the pH value regulating ethanol elution with 0.5mol/L sodium hydroxide aqueous slkali is 6.5 ~ 7.5, place, filter, concentration and recovery ethanol, obtaining ethanol content is the solution of 10% ~ 15%, pass through polyamide resin column, first wash with water to eluent in closely colourless, 1.2 ~ 1.5 times of the mixture quality that the quality of the water used is step (1) Raw medicine, be the ethanol elution of 90% ~ 95% with determining alcohol again, collect ethanol elution, the concentration used is 1.3 ~ 1.5 times of the mixture quality that the quality of the ethanol of 90% ~ 95% is step (1) Raw medicine, reclaim ethanol, concentrated, drying under reduced pressure, obtain and get dry extract,

(3) dry cream obtained for step (2) is placed in super micron mill pulverizes 1.5-2 hour, pulverize, sieve, obtain 350-400 object micropowders;

(4), after the micropowders that step (3) is obtained being added suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, obtained granule.

9. the Chinese medicine composition of the skin pruritus after hemodialysis of the treatment as described in as arbitrary in claim 1-8 is treating the application in skin pruritus disease drug after hemodialysis.