CN104436109A

CN104436109A - Traditional Chinese medicine preparation for treating scleroderma

Info

Publication number: CN104436109A
Application number: CN201410636945.2A
Authority: CN
Inventors: 景东旭
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-10-31
Filing date: 2014-10-31
Publication date: 2015-03-25

Abstract

The invention provides a traditional Chinese medicine preparation for treating scleroderma. The traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight: 15 parts of herba epimedii, 15 parts of baked ginger, 30 parts of semen cuscutae, 15 parts of radix aconiti lateralis preparata, 15 parts of angelica, 10 parts of red peony root, 15 parts of radix paeoniae alba, 30 parts of caulis spatholobi, 18 parts of myrrh, 15 parts of cassia twig, 10 parts of notopterygium root, 12 parts of radix angelicae tuhuo, 60 parts of adlay, 30 parts of astragalus membranaceus and 15 parts of codonopsis pilosula. The medicinal effects of the selected raw material medicines are complementary, the mutual inhibition, mutual restraint and mutual detoxication of the medicines are avoided, the mutual promotion and mutual assistance effects of the medicines are significant, the traditional Chinese medicine preparation has the functions of promoting blood circulation to remove meridian obstruction, invigorating spleen and supplementing qi, and dispelling cold and tonifying kidney, and is an internal pure Chinese herbal medicine preparation for treating scleroderma.

Description

Treat sclerodermatous Chinese medicine preparation

Technical field

The invention belongs to the field of Chinese medicines, be specifically related to one and treat sclerodermatous Chinese medicine preparation.The sclerodermatous Chinese medicine preparation for the treatment of of the present invention, has effect of promoting blood circulation to remove obstruction in the collateral, invigorating the spleen and benefiting QI, cold expelling the kidney invigorating, is used for the treatment of scleroderma determined curative effect.

Background technology

Scleroderma is a kind of with dermal inflammatory, degeneration, connective tissue disease that to thicken with fibrosis and then sclerosis and atrophy be feature, and this disease can cause Multisystem damage.Wherein systemic sclerosis except skin, synovial membrane, refer to (toe) tremulous pulse and occur degeneration except, the internal organs such as digestive tract, lung, heart and kidney also can be got involved.The sclerodermatous cause of disease may under the factor effects such as heredity, environmental factors (viral infection, chemical substance are as silicon etc.), estrogen, cell and humoral immunization exception, fibroblast is synthesized and secretes collagen to be increased, and causes the fibrosis of skin and internal organs.Chemical substance or viral infection are the environmental factorss affecting disease susceptibility.The crowd being often exposed to silicon dioxide in work suffers from this sick relative risk and increases.Main clinical manifestation: onset symptom is nonspecific often, comprises Raynaud phenomenon, weak, musculoskeletal pain, just occurs other indications after these Symptoms last a few weeks or months.Having specific scleroderma early clinical manifestation is that skin turgor thickens, and starts from finger and hands.There is diversified performance subsequently, mainly at skin, lung, heart, digestive tract or kidney.Without in the patient of Raynaud phenomenon, the danger of renal involvement increases.According to the degree that skin is invaded, scleroderma can be divided into several hypotype: the 1. patient of local scleroderma only distal limb pachyderma, trunk is inviolable.2. diffuse scleroderma patients thickens for far-end of limb and near-end and/or body skin.

Summary of the invention

One is the object of the present invention is to provide to treat sclerodermatous Chinese medicine preparation.The sclerodermatous Chinese medicine preparation for the treatment of of the present invention, has effect of promoting blood circulation to remove obstruction in the collateral, invigorating the spleen and benefiting QI, cold expelling the kidney invigorating, is used for the treatment of scleroderma determined curative effect.

The technical solution used in the present invention: the sclerodermatous Chinese medicine preparation of described treatment, the raw medicinal material selected and components by weight percent respectively: Herba Epimedii 15 parts, Rhizoma Zingiberis Preparatum 15 parts, Semen Cuscutae 30 parts, Radix Aconiti Lateralis Preparata 15 parts, Radix Angelicae Sinensis 15 parts, Radix Paeoniae Rubra 10 parts, the Radix Paeoniae Alba 15 parts, Caulis Spatholobi 30 parts, Myrrha 18 parts, Ramulus Cinnamomi 15 parts, Rhizoma Et Radix Notopterygii 10 parts, Radix Angelicae Pubescentis 12 parts, Semen Coicis 60 parts, the Radix Astragali 30 parts, Radix Codonopsis 15 parts.

In the raw materials of traditional Chinese medicinal materials that the present invention chooses, its effect and pharmacological action respectively: Herba Epimedii: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension.Herba Epimedii stem and leaf contains icariine and volatile oil.Verified, Herba Epimedii has the effect of androgen sample, and its effect is better than Gecko and Hippocampus.Clinical display, it is by promoting gonepoiesis, after making seminal vesicle be full of seminal fluid, conversely again can sensation neural, thus excitability for and cause erection.Meanwhile, Herba Epimedii can also suppress vasomotor center, and expansion peripheral vessels, makes blood pressure drops, and can antitussive, eliminate the phlegm, relieving asthma, also have significant inhibitory action to poliovirus, Staphylococcus albus, staphylococcus aureus etc.

Rhizoma Zingiberis Preparatum: [effect] warming the meridian for stopping bleeding; Warming middle-JIAO to relieve pain.[effect classification] warming middle-JIAO to relieve pain medicine; Meridian-warming hemostatic.[meridian distribution of property and flavor] nature and flavor are bitter, puckery, temperature.Pungent, hot.Return spleen, stomach, kidney, the heart, lung meridian.[function cures mainly] warming spleen and stomach for dispelling cold, warming the meridian for stopping bleeding.For Deficiency and coldness of spleen and stomach, stomachache is vomited and diarrhoea, and tell nosebleed metrorrhagia, yang deficiency is lost blood.

Semen Cuscutae: Semen Cuscutae acrid in the mouth, sweet, slightly warm in nature; Return liver,kidney,spleen warp; Gas and property are delayed, and can float and can sink.There is the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, the solid tire of spleen invigorating.Cure mainly lumbago tinnitus, impotence and seminal emission, quench one's thirst, sterile, enuresis incontinence, stranguria with turbid discharge leukorrhagia, the head is dim, and lack of appetite is had loose bowels, frequent fetal movement.

Radix Aconiti Lateralis Preparata: [nature and flavor with return through] are pungent, sweet, hot greatly; Poisonous.GUIXIN, kidney, spleen channel.[function with cure mainly] recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang, by wind-cold damp pathogen.For YANG-depletion collapse, cold extremities faint pulse, sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, arthralgia due to cold-dampnes.

Radix Angelicae Sinensis: [chemical composition] is containing basic lactone, n-butene acyl lactone, ferulic acid, nicotinic acid, sucrose and several amino acids, and sesquiterpenoids etc.[meridian distribution of property and flavor] is warm in nature, hides sweet, pungent.Return liver, the heart, spleen channel.[function cures mainly] is enriched blood and is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.

Radix Paeoniae Rubra: function, clots absorbing, pain relieving, removing heat from blood, detumescence.Cure mainly: control the stagnant amenorrhea of the stasis of blood, hernia abdominal mass is gathered, suffer from abdominal pain, hypochondriac pain, epistaxis, dysentery, discharging fresh blood stool, conjunctival congestion, carbuncle, injury from falling down.

The Radix Paeoniae Alba: chemical composition: paeoniflorin, paeonol, paeoniflorin, still containing benzoic acid, volatile oil, fatty oil, resin, tannin, sugar, starch, phlegmatic temperament, protein, cupreol and triterpenes etc.Property of medicine effect: the Radix Paeoniae Alba is cool in nature, bitter in the mouth acid, is slightly cold, has the effects such as blood-supplementing blood-nourishing, suppressing liver-YANG, easing the affected liver to relieve pain, astringing YIN to stop sweating, be applicable to fever due to yin deficiency, menoxenia, the breast abdomen pain over the hypochondriac region, extremity contraction suddenly, dysentery stomachache, spontaneous sweating, metrorrhagia, the inferior disease of band.Paeoniflorin has antibacterial, antipyretic, antiinflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjustment blood glucose.Radix Paeoniae Alba decoct can suppress dysentery bacterium, streptococcus pneumoniae, escherichia coli, Bacillus typhi, Hemolytic streptococcus, bacillus pyocyaneus etc.

Caulis Spatholobi: rattan contains epifriedelanol, daucosterol, cupreol, 7-ketone group-cupreol (7-oxo-β-sitosterol); formoononetin, ononin, prunusetin., afromosin; Dai, 3,7-dihydroxy-6-melonia flavonol, epicatechin; Isoliquiritigenin 3,4,2 '; 4 '-tetrahydroxy chalcone derivative, Licochalcone A, lucerne pig phenol; protocatechuic acid, 9-methoxyl group coumestrol, Semen Cajani isoflavone.Bitter but slightly sweet taste, warm in nature, return liver, the heart, kidney channel; Red complexion enters blood, and matter profit row is loose; There is relaxing muscles and tendons to promote blood circulation, effect of nourishing blood for regulating menstruation; Cure mainly rheumatic arthralgia, numb hand and foot, quadriplegia, menoxenia, blockage of menstruation, dysmenorrhea, amenorrhea, leukopenia.

Myrrha: nature and flavor: bitter, pungent is flat.Enter liver, spleen, the heart, kidney channel.[effect]: loose blood blood stasis removing, subduing swelling and relieving pain.Cure mainly: raw property or lymphatic temperament disease, as raw property arthralgia, sciatica, oral cavity pain, has sore throat, cold cough, moist abundant expectoration, bronchiectasis, eczema abscess, menoxenia, dysuria.

Ramulus Cinnamomi: [curing mainly] expelling cold and relieving exterior syndrome; Promoting the flow of QI-blood by warming the meridian; Activating YANG and prormoting functioning of QI.Main exterior syndrome due to wind-cold; Arthralgia due to cold-dampnes; Extreme cold of the limbs; Amenorrhea dysmenorrhea; Lump in the abdomen lumps; The thoracic obstruction; Cardiopalmus; Phlegm retention; Dysuria.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.[effect] diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, dispersing cold for relieving pain.

Rhizoma Et Radix Notopterygii: [effect]: loose exterior cold; Wind-damp dispelling; Profit joint; Pain relieving.Main affection of exogenous wind-cold; Have a headache lossless; Mimeograph cold-damp numbness; Edema due to wind pathogen edema; Sore swollen toxin.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.Induce sweat cold expelling, expelling wind and dampness, pain relieving.

Radix Angelicae Pubescentis: meridian distribution of property and flavor: pungent, bitter, tepor.Return liver, kidney, urinary bladder channel.Function cures mainly expelling wind and dampness; Dispersing cold for relieving pain.For anemofrigid-damp arthralgia; Lumbocrural pain; Few cloudy volt wind headache, headache toothache.

Semen Coicis: sweet in the mouth, light, cold nature.There are invigorating spleen to remove dampness, clearing away heat and discharging pus function.For the disease such as diarrhea due to hypofunction of the spleen edema beriberi, leucorrhea, wet, arthralgia, acute appendicitis, consumptive lung disease.Still for cancer and multiple warts such as gastric cancer, cervical cancer, chorionic epithelioma.[chemical composition] leaf is containing alkaloid, and seed contains much starch and multivitamin.The main main component also contained is sterin, several amino acids, Semen Coicis oil, Semen Coicis fat, carbohydrate, vitamin B group etc.; [curing mainly]: control cold syndrome of the stomach pain, deficient qi and blood.[meridian distribution of property and flavor]: sweet, warming the spleen, stomach warp.

The Radix Astragali: have 1, an exterior deficiency spontaneous perspiration, is used for the weak caused spontaneous perspiration of body void table.2, night sweat due to yin deficiency; 3, acute nephritis edema, for the void edema caused by YANG QI deficiency; 4, oedema due to chronic nephritis, spleen person who suffer from deficiency of kidney Yang; 5, yang-energy is weak, caves in, have and promote diabrosis and limitation effect for skin infection not diabrosis for a long time.6, skin infection is burst for a long time and is not healed, and after skin infection diabrosis, does not close up for a long time, has the effect of promoting tissue regeneration and wound healing; 7, syndrome of deficiency of spleen qi, weak asthenia, has loose bowels, sinking of QI of middle-JIAO, and internal organs prolapse, the indigestion and loss of appetite all diseases of lack of appetite.8, syndrome of deficiency of lung qi.With the passing of time, shortness of breath and tired spirit, expectorant harmony brings up in lung is unable cough with asthma.9, hyperhidrosis and edema.10, weak for the deficiency of vital energy, fatigue and weakness, or sinking of QI of middle-JIAO, proctoptosis, uterine prolapse.Nature and flavor: sweet, tepor.Gui Jing: return lung, spleen, liver, kidney channel; Have enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.

Radix Codonopsis: there is invigorating the spleen and replenishing QI, effect of spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.Meridian distribution of property and flavor: property is put down, sweet in the mouth, micro-acid.Return spleen, lung meridian.Chemical composition: Radix Codonopsis is containing triterpenoid compound freidelin (friedelin), alnulin acetas, bessisterol and glycoside thereof, Δ 7-stigmastenol and glycoside, spinach sterone (spinesterone).Another containing atractylenoide Ⅲ (atractylenolide III), atractyloide II (atractylenolide II), syringic aldehyde (syringaldehyde), Syringin (syringin), vanillic acid (vanillic acid), 5-hydroxyl-2-piconol (5-hydroxy-2-pyridinemethanol), α-furyl carboxylic acid (α-furancarboxylic acid), n-hexyl-glycoside (n-hexyl-β-D-glucopyranoside), ethyl-α-D-fructofuranoside (ethyl-α-D-fructofuranoside), and nicotinic acid, 4 kinds of heteropolysaccharide and monosaccharide etc.Still containing tangshenoside I, codonolactone and codopiloic acid.

Complementary with the raw medicinal material property of medicine effect selected by top, evade the choosing of the mutual inhibition of compatibility between medicine, mutual restraint between two drugs, the mutual-detoxication, making medicine mutual reinforcement between, mutual-assistance effect significantly, have effect of promoting blood circulation to remove obstruction in the collateral, invigorating the spleen and benefiting QI, cold expelling the kidney invigorating, is the sclerodermatous pure Chinese herbal medicine composition preparation for oral administration for the treatment of.There is during clinical practice good precise effects.

Sclerodermatous treatment is inquired at present and is differed, and I am according to many decades in recent years " clinical experience, know from experience in conjunction with original medication, application modern medicines preparation technology develops the sclerodermatous pure Chinese medicinal preparation for oral administration for the treatment of, has definite curative effect.Because its effect is good, and not easily predicted by the compound of prior art, doctor trained in Western medicine curative effect also not as Chinese herbal medicine curative effect, therefore effectively will cure sclerodermatous pure Chinese herbal medicine composition formulation development for oral administration out, can be applied to clinical, for more patient removes misery.

Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations.Such as these crude drug pulverize mix homogeneously powder can be taken after mixing it with water; Can by these crude drug together decocting, then concentrated decocting liquid is taken, or concentrated decocting liquid is condensed into cream is processed into pill and takes; In order to make each raw material of this medicine play drug effect better, carry out special extraction for certain crude drug, as ethanol extraction, these can not be used for limiting the scope of the invention.

Medicine of the present invention has effect of promoting blood circulation to remove obstruction in the collateral, invigorating the spleen and benefiting QI, cold expelling the kidney invigorating, is used for the treatment of scleroderma.The present inventor through repeatedly studying, and passes through the checking repeatedly of clinical trial, finally have found the endo-medicine of better curative effect, thus completes the present invention.

Clinical test of pesticide effectiveness material and model case:

1. Lee XX, female, 39 years old.August 29 2007 first visit date.

Find after patient catches a cold within 2004 8,9, to work below the moon that two finger ends feel cold, pale or livid purple, with low grade fever, extremities joint is ached, general malaise.Winter in 2005 finds that nocturia increases, and brothers' cold type of pain is serious, even if it is ice-cold also to feel brothers in the summer of sweltering heat.Limbs skin is hardening, solid as leather, and in plank sample, the cool and gloss touched, has not easily seized.Facial area skin is wax sample gloss simultaneously, and wrinkle disappears, and hypomimia is as visor sample.In July, 2007, exacerbation of symptoms, anorexia, conscious difficulty in opening mouth, it is unfavorable to swallow.The large hypothenar of hands and both legs amyotrophy.Western medicine is diagnosed as systemic sclerosis.Patient's scleroderma 3 or four years, skin lesion is based on face, extremity, and nocturia increases, cold limbs, and general joint is aching and tired, dysphagia, anorexia, pale tongue, white and thin fur, deep-thready pulse.This belongs to insufficiency of kidney-YANG, weakened defensive QI, and cold-evil stagnates, and hinders caused by the skin meridians, should warming kidney for dispelling cold, promoting blood circulation to remove obstruction in the collateral.After clothes we 6 doses, finger pain disappears, but still sense cold limbs, indigestion and loss of appetite.After continuing to take we 30 doses, face and limbs skin softness, wrinkle occurs, acra spasm phenomenon disappears, the positive normal pulse of tongue.Continue to take we 20 with consolidate curative effect.

Method and effective dose: Herba Epimedii 15 parts, Rhizoma Zingiberis Preparatum 15 parts, Semen Cuscutae 30 parts, Radix Aconiti Lateralis Preparata 15 parts, Radix Angelicae Sinensis 15 parts, Radix Paeoniae Rubra 10 parts, the Radix Paeoniae Alba 15 parts, Caulis Spatholobi 30 parts, Myrrha 18 parts, Ramulus Cinnamomi 15 parts, Rhizoma Et Radix Notopterygii 10 parts, Radix Angelicae Pubescentis 12 parts, Semen Coicis 60 parts, the Radix Astragali 30 parts, Radix Codonopsis 15 parts.Get prescription ormal weight tcm and herbal slice, put in suitable decocting device, add clear water appropriate, soak suitable time, be heated to boil, keep slight boiling condition certain hour (about 25 ~ 30 minutes), be separated fried liquid, medicinal residues add water and decoct in right amount, after regulation decoction 2 ~ 3 times, merge fried liquid, filter or settlement separate fried liquid for.

Decoction oral is main, and every day takes orally for 2 times sooner or later, each 150ml decoction being taken warmly.Decoction then acts on fast and power is high, is adapted to the more anxious severe one of the state of an illness.As lighter in the state of an illness or slow person, is preferably that pill is for oral administration asks its merit.

Detailed description of the invention

The sclerodermatous Chinese medicine preparation of described treatment, the raw medicinal material selected and components by weight percent respectively: Herba Epimedii 15 parts, Rhizoma Zingiberis Preparatum 15 parts, Semen Cuscutae 30 parts, Radix Aconiti Lateralis Preparata 15 parts, Radix Angelicae Sinensis 15 parts, Radix Paeoniae Rubra 10 parts, the Radix Paeoniae Alba 15 parts, Caulis Spatholobi 30 parts, Myrrha 18 parts, Ramulus Cinnamomi 15 parts, Rhizoma Et Radix Notopterygii 10 parts, Radix Angelicae Pubescentis 12 parts, Semen Coicis 60 parts, the Radix Astragali 30 parts, Radix Codonopsis 15 parts.

The sclerodermatous Chinese medicine preparation for the treatment of of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations.Get prescription ormal weight tcm and herbal slice, put in suitable decocting device, add clear water appropriate, soak suitable time, be heated to boil, keep slight boiling condition certain hour (about 25 ~ 30 minutes), be separated fried liquid, medicinal residues add water and decoct in right amount, after regulation decoction 2 ~ 3 times, merge fried liquid, filter or settlement separate fried liquid for.

Claims

1. the sclerodermatous Chinese medicine preparation for the treatment of, it is characterized in that, the raw medicinal material selected and components by weight percent respectively: Herba Epimedii 15 parts, Rhizoma Zingiberis Preparatum 15 parts, Semen Cuscutae 30 parts, Radix Aconiti Lateralis Preparata 15 parts, Radix Angelicae Sinensis 15 parts, Radix Paeoniae Rubra 10 parts, the Radix Paeoniae Alba 15 parts, Caulis Spatholobi 30 parts, Myrrha 18 parts, Ramulus Cinnamomi 15 parts, Rhizoma Et Radix Notopterygii 10 parts, Radix Angelicae Pubescentis 12 parts, Semen Coicis 60 parts, the Radix Astragali 30 parts, Radix Codonopsis 15 parts;

Its preparation method: get Herba Epimedii 15 parts, Rhizoma Zingiberis Preparatum 15 parts, Semen Cuscutae 30 parts, Radix Aconiti Lateralis Preparata 15 parts, Radix Angelicae Sinensis 15 parts, Radix Paeoniae Rubra 10 parts, the Radix Paeoniae Alba 15 parts, Caulis Spatholobi 30 parts, Myrrha 18 parts, Ramulus Cinnamomi 15 parts, Rhizoma Et Radix Notopterygii 10 parts, Radix Angelicae Pubescentis 12 parts, Semen Coicis 60 parts, the Radix Astragali 30 parts, Radix Codonopsis 15 parts; Prescription ormal weight tcm and herbal slice, put in suitable decocting device, add clear water appropriate, soak suitable time, be heated to boil, keep slight boiling condition certain hour (about 25 ~ 30 minutes), be separated fried liquid, medicinal residues add water and decoct in right amount, after regulation decoction 2 ~ 3 times, merge fried liquid, filter or settlement separate fried liquid for.