CN104784634A

CN104784634A - Traditional Chinese medicine preparation for treating diffuse systemic scleroderma

Info

Publication number: CN104784634A
Application number: CN201510147294.5A
Authority: CN
Inventors: 刘凤伟; 张丽
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-03-31
Filing date: 2015-03-31
Publication date: 2015-07-22
Anticipated expiration: 2035-03-31
Also published as: CN104784634B

Abstract

The invention discloses a traditional Chinese medicine preparation for treating diffuse systemic scleroderma. The traditional Chinese medicine preparation selects the following raw material medicines by weight: 20-30 g of astragalus membranaceus, 10-20 g of Chinese yam, 10-20 g of angelica sinensis, 10-20 g of pericarpium citri reticulatae, 10-20 g of agilawood, 10-20 g of tangerine, 10-20 g of curcuma zedoary, 10-20 g of radix linderae, 10-20 g of fructus liquidambaris, 8-15 g of cassia twig, 8-12 g of Chinese honeylocust spine, 8-12 g of pangolin scales, 8-12 g of sargent gloryvine, 8-12 g of rhizoma pinelliae, 8-12 g of asarum and 8-12 g of monkshood. The traditional Chinese medicine preparation has the main function of tonifying and benefiting qi in spleens and lungs and the auxiliary functions of promoting blood circulation to remove blood stasis, and warming meridians and expelling cold, a human body is abundant in vital qi, blood circulation is smoothed, defensive qi and nutrient blood are filled and reconciled, skin viscera is warmed, moistened and nourished, yin and yang are interactive, and both the qi and the blood are abundant and active; therefore, the efficacies of benefiting qi and removing blood stasis, softening hard mass and eliminating rheumatism are achieved.

Description

A kind of Chinese medicine preparation for the treatment of diffusivity systemic sclerosis

Technical field

The invention belongs to the field of Chinese medicines, specifically a kind of Chinese medicine preparation can treating diffusivity systemic sclerosis.

Background technology

Systemic sclerosis (SSc) is a kind of disease turning to feature with multiple organ inflammation and fiber, now thinks and comprises two Main Subtypes, i.e. limitation skin-type (former CREST syndrome) and diffuse scleroderma.The main distinction of the two is to be in progress speed, the former often has long-term Raynaud phenomenon medical history before system pathological changes occurs, pachyderma is confined to hand and face, often there is acra ulcer and esophageal dysmotility, also can occur the fatal complication such as intestinal motility decline and pulmonary hypertension, impaired heart and kidney is rare; The latter is acute onset, occurs General Symptoms in the short time, arthritis, carpal tunnel syndrome, and hands and lower limb obvious tumefaction, thicken to body skin Progressive symmetric erythrokeratodermia from hands, and cardio-renal disease becomes serious, and anti-Scl-70 is positive.

Existing remedy measures mainly based on primary disease fall ill three fundamental mechanisms relating to and tissue fibering, autoimmune response and vascular function abnormal.Concrete measure is as warming, physical therapy, vasodilation, antacid, antiarrhythmic drug, angiotensin converting enzyme inhibitor (ACEI) etc.Some comparatively traditional Therapeutic Method and medicine are as calcium channel blocker, corticosteroid, Beracilline, NSAID (non-steroidal anti-inflammatory drug), plasmapheresis etc. at present, most curative effect affirmative or not obvious.Therefore, debate the principle of disease treating, treating both the principal and secondary aspects of a disease according to the traditional Chinese medical science, in recent years, we provide and a kind ofly mix fried Chinese medicine preparation hair growth disease by multiple Chinese herbal medicine and achieve good efficacy.

Summary of the invention

Instant invention overcomes the technical deficiency existed in treatment diffusivity systemic sclerosis at present, provide a kind of evident in efficacy, have no side effect, the high and Chinese medicine preparation of the treatment diffusivity systemic sclerosis not easily recurred of cure rate.

The technical solution adopted in the present invention is:

Treat a Chinese medicine preparation for diffusivity systemic sclerosis, it is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:

Radix Astragali 20-30 gram, Rhizoma Dioscoreae 10-20 gram, Radix Angelicae Sinensis 10-20 gram, Pericarpium Citri Reticulatae 10-20 gram, Lignum Aquilariae Resinatum 10-20 gram, Exocarpium Citri Rubrum 10-20 gram, Rhizoma Curcumae 10-20 gram, Radix Linderae 10-20 gram, Fructus Liquidambaris 10-20 gram, Ramulus Cinnamomi 8-15 gram, Spina Gleditsiae 8-12 gram, Squama Manis 8-12 gram, Caulis Sargentodoxae 8-12 gram, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8-12 gram, Herba Asari 8-12 gram, Radix Aconiti Lateralis Preparata 8-12 gram.

As this kind of prioritization scheme:

Described Chinese medicine preparation is made up of the raw material of following weight portion:

The Radix Astragali 20 grams, Rhizoma Dioscoreae 10 grams, Radix Angelicae Sinensis 10 grams, Pericarpium Citri Reticulatae 10 grams, Lignum Aquilariae Resinatum 10 grams, Exocarpium Citri Rubrum 10 grams, Rhizoma Curcumae 10 grams, the Radix Linderae 10 grams, Fructus Liquidambaris 10 grams, Ramulus Cinnamomi 8 grams, Spina Gleditsiae 8 grams, Squama Manis 8 grams, Caulis Sargentodoxae 8 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 grams, Herba Asari 8 grams, Radix Aconiti Lateralis Preparata 8 grams.

As this kind of prioritization scheme:

The Radix Astragali 22 grams, Rhizoma Dioscoreae 12 grams, Radix Angelicae Sinensis 12 grams, Pericarpium Citri Reticulatae 12 grams, Lignum Aquilariae Resinatum 12 grams, Exocarpium Citri Rubrum 12 grams, Rhizoma Curcumae 12 grams, the Radix Linderae 12 grams, Fructus Liquidambaris 12 grams, Ramulus Cinnamomi 9 grams, Spina Gleditsiae 9 grams, Squama Manis 9 grams, Caulis Sargentodoxae 9 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 9 grams, Herba Asari 9 grams, Radix Aconiti Lateralis Preparata 9 grams.

As this kind of prioritization scheme:

The Radix Astragali 24 grams, Rhizoma Dioscoreae 14 grams, Radix Angelicae Sinensis 14 grams, Pericarpium Citri Reticulatae 14 grams, Lignum Aquilariae Resinatum 14 grams, Exocarpium Citri Rubrum 14 grams, Rhizoma Curcumae 14 grams, the Radix Linderae 14 grams, Fructus Liquidambaris 14 grams, Ramulus Cinnamomi 11 grams, Spina Gleditsiae 9 grams, Squama Manis 8 grams, Caulis Sargentodoxae 9 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 grams, Herba Asari 9 grams, Radix Aconiti Lateralis Preparata 8 grams.

As this kind of prioritization scheme:

The Radix Astragali 26 grams, Rhizoma Dioscoreae 16 grams, Radix Angelicae Sinensis 16 grams, Pericarpium Citri Reticulatae 16 grams, Lignum Aquilariae Resinatum 16 grams, Exocarpium Citri Rubrum 16 grams, Rhizoma Curcumae 16 grams, the Radix Linderae 16 grams, Fructus Liquidambaris 16 grams, Ramulus Cinnamomi 13 grams, Spina Gleditsiae 10 grams, Squama Manis 10 grams, Caulis Sargentodoxae 10 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 10 grams, Herba Asari 10 grams, Radix Aconiti Lateralis Preparata 10 grams.

As this kind of prioritization scheme:

The Radix Astragali 28 grams, Rhizoma Dioscoreae 18 grams, Radix Angelicae Sinensis 18 grams, Pericarpium Citri Reticulatae 18 grams, Lignum Aquilariae Resinatum 18 grams, Exocarpium Citri Rubrum 18 grams, Rhizoma Curcumae 18 grams, the Radix Linderae 18 grams, Fructus Liquidambaris 18 grams, Ramulus Cinnamomi 14 grams, Spina Gleditsiae 11 grams, Squama Manis 11 grams, Caulis Sargentodoxae 11 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 11 grams, Herba Asari 11 grams, Radix Aconiti Lateralis Preparata 11 grams.

As this kind of prioritization scheme:

The Radix Astragali 30 grams, Rhizoma Dioscoreae 20 grams, Radix Angelicae Sinensis 20 grams, Pericarpium Citri Reticulatae 20 grams, Lignum Aquilariae Resinatum 20 grams, Exocarpium Citri Rubrum 20 grams, Rhizoma Curcumae 20 grams, the Radix Linderae 20 grams, Fructus Liquidambaris 20 grams, Ramulus Cinnamomi 15 grams, Spina Gleditsiae 12 grams, Squama Manis 8-12 gram, Caulis Sargentodoxae 12 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 12 grams, Herba Asari 12 grams, Radix Aconiti Lateralis Preparata 12 grams.

The instructions of taking of Chinese medicine preparation of the present invention is: after being mixed by the raw material Chinese medicine of above-mentioned weight proportion, traditionally medicine decocting method adds water fried, extracting juice 300ml, takes for 2 times, every day 1 dose respectively at morning, evening point.Within 30 days, be 1 course for the treatment of, 3 courses for the treatment of of general treatment.

The raw material Chinese medicine of above-mentioned Chinese medicine preparation:

The Radix Astragali, sweet in the mouth, slightly warm in nature; Return spleen, lung meridian.There is benefiting QI for strengthening the superficies, tonifying Qi and lifting yang, promoting pus discharge and tissue regeneration strengthening, effect of inducing diuresis to remove edema.

Rhizoma Dioscoreae, sweet in the mouth, property is put down; Return spleen, lung, kidney channel.There is supplementing QI and nourishing YIN, mend strengthening spleen and lung, effect of tonifying the kidney to consolidate the essence.

Radix Angelicae Sinensis, acrid in the mouth, warm in nature; Return liver, the heart, spleen channel.Having enriches blood invigorates blood circulation, effect of pain relieving intestine moistening.

Pericarpium Citri Reticulatae, acrid in the mouth, hardship, warm in nature; Return spleen, stomach, lung meridian.There is regulating the flow of Qi and the middle Jiao, drying dampness to eliminate phlegm, effect of diuretic relieving constipation.

Lignum Aquilariae Resinatum, acrid in the mouth, hardship, slightly warm in nature; Return spleen, stomach, kidney channel.There are promoting the circulation of QI to relieve pain, warming middle-JIAO to arrest vomiting, effect of the kidney warming improving inspiration by invigorating kidney-QI.

Exocarpium Citri Rubrum, bitter in the mouth, pungent, warm in nature; Return lung, spleen channel.There is regulating qi-flowing for strengthening spleen, effect of drying dampness to eliminate phlegm.

Rhizoma Curcumae, acrid in the mouth, hardship, warm in nature; Return liver, spleen channel.There is removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving, effect of expelling wind and removing dampness.

The Radix Linderae, acrid in the mouth, warm in nature; Return lung, spleen, kidney, urinary bladder channel.There are promoting the circulation of QI to relieve pain, effect of warming kidney for dispelling cold.

Fructus Liquidambaris, bitter in the mouth, property is put down; Return liver, kidney channel.There is dispelling wind and removing obstruction in the collateral, effect of diuretic dehumidifying.

Ramulus Cinnamomi, acrid in the mouth, sweet, warm in nature; GUIXIN, spleen, urinary bladder channel.There is expelling pathogenic factors from muscles by diaphoresis, warming the meridian for promoting the flow of YANG QI, effect of expelling wind and removing dampness.

Spina Gleditsiae, acrid in the mouth, warm in nature; Return liver, stomach warp.There is evacuation of pus of drawing out pus by applying a plaster to the affected part, effect of promoting blood circulation and detumescence.

Squama Manis, salty in the mouth, cold nature; Return liver, stomach warp.There is stimulating milk secretion of stimulating the menstrual flow, detumescence and apocenosis, effect of expel wind to dredge collateral.

Caulis Sargentodoxae, bitter in the mouth, property is put down; Return large intestine channel.There is heat-clearing and toxic substances removing, effect of promoting blood circulation and stopping pain.

Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), acrid in the mouth, warm in nature; Return spleen, stomach, lung meridian.There is stopping nausea and vomiting by lowering the adverse flow of QI, damp eliminating clears phlegm.

Herba Asari, acrid in the mouth, warm in nature; Return lung, kidney channel.There is wind-expelling pain-stopping, expelling cold and relieving exterior syndrome, warming the lung to resolve fluid-retention, effect of a surname's clearing the nasal passage.

Radix Aconiti Lateralis Preparata, taste great Xin, extremely hot in nature; GUIXIN, spleen, kidney channel.There is recuperating depleted YANG and rescuing the patient from collapse, warming and recuperating the spleen and kidney, effect of dispersing cold for relieving pain.

Diffusivity systemic sclerosis belongs to Chinese medical ' arthralgia syndrome ', " BI-syndrome related to skin ", " deficient " category.It is generally acknowledged, this disease is mainly due to deficiency of both the splenic and pulmonary QI, and deficiency of kidney-essence, interspaces of skin and muscles being loose, weakened defensive QI, wind-cold damp pathogen is taken advantage of a weak point in opponent's defence and attacked, and hinders between skin, muscle, fascia, so that disharmony of nutrient QI with defensive QI, and meridians impatency, coagulation of QI-blood, numbness plug is obstructed to be formed.End-stage disease is along with healthy energy day by day loss, and progressively deeply, viscera function is badly damaged pathogen, can occur the internal organs pathological changes such as uncomfortable in chest, tachypnea, cough with asthma, cardiopalmus, vomiting and diarrhoea, the cancer of the esophagus.On the whole, " void " and " stasis of blood " two aspect is be unable to do without.Wherein the deficiency of vital energy is this, and blood stasis promotes unable for mark, the deficiency of vital energy, causes the sluggish stasis blocking of blood, can not moisten foster extremity bones of the body collectively, internal organs skin and flesh, then occurs the symptoms such as skin sclerosis atrophy, joint stiffness deformity, viscera function go down.Therefore, should based on QI invigorating warming YANG in treatment, blood circulation promoting and blood stasis dispelling is laid equal stress on.

In Chinese medicine preparation of the present invention, the Radix Astragali, Radix Aconiti Lateralis Preparata, Rhizoma Dioscoreae energy kidney and spleen invigorating, QI invigorating warming YANG are monarch drug; Radix Angelicae Sinensis, Lignum Aquilariae Resinatum, Exocarpium Citri Rubrum, Rhizoma Curcumae, Fructus Liquidambaris can enrich blood invigorate blood circulation, removing blood stasis circulation of qi promoting, expelling wind and removing dampness; Spina Gleditsiae, Squama Manis, Caulis Sargentodoxae energy heat-clearing and toxic substances removing, detumescence and apocenosis, be all ministerial drug; Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Herba Asari, Pericarpium Citri Reticulatae energy regulating the flow of Qi and the middle Jiao, drying dampness to eliminate phlegm, benefit strengthening spleen and lung kidney are adjuvant drug; Ramulus Cinnamomi, Radix Linderae energy dispersing wind-cold, warming the meridian and promoting blood circulation, and abnormal smells from the patient is all light, can enter flesh table, row space between skin and muscles, draw all medicines and to go directly disease institute, think and make medicine.Full side is to mend the gas of strengthening spleen and lung, and blood circulation promoting and blood stasis dispelling, dispelling cold by warming the meridian are auxiliary, makes body healthy energy abundant, blood is unobstructed, battalion Wei Zhiqi fill contain be in harmonious proportion, skin internal organs be able to warm moisten foster, make negative and positive make mutual Ji mutually, QI and blood abundance is active, thus reach QI invigorating clots absorbing, effect that softening the hard mass exempts from numbness.

For investigating the clinical efficacy of medicine of the present invention further, we have selected 76 routine diffuse scleroderma out-patients and carry out clinical trial, wherein man 41 example, female 35 example; 12 ~ 79 years old age, average 45 years old; The course of disease half a year ~ 18 years, average 3.6 years.Be divided into treatment group and matched group at random, wherein treatment group 40 example, matched group 36 example.Two groups of patients compare in age, sex, the state of an illness, the course of disease etc., and no significant difference (P > 0.05), has comparability.

Diagnostic criteria: the sclerderm change of metacarpophalangeal joints near-end, can involve whole limbs, face, whole body and trunk.Minor criteria: 1. point scleroderma: above-mentioned skin change is only limitted to hands and refers to; 2. finger tip has depressed scar and thumb pad to disappear; 3. two lung basilar fibers.All have 1 main standard or 2 minor criterias and diagnosable.Other contribute to the performance diagnosed: Raynaud phenomenon, polyarthritis or arthralgia, and esophageal peristalsis is abnormal, the swelling of dermatopathology collagen fiber and fibrosis, immunologic test ANA, Anti-Scl-70 and centromere antibody (ACA) positive.

Criterion of therapeutical effect:

Cure: transference cure, skin deliquescing, the pathological changes basic controlling of each organ systems, the every Testing index of laboratory recovers normal.

Effective: cardinal symptom disappears, the basic deliquescing of skin, the pathological changes major part of each organ systems controls, and laboratory parameters major part recovers normal.

Effective: partial symptoms, sign disappear, the basic deliquescing of skin, the lesion portion of each organ systems controls, and laboratory parameters some projects are recovered normally or to some extent to take a turn for the better.

Invalid: the pathological changes of symptom, sign, each organ systems, various laboratory parameters are all without improvement.

Therapeutic Method:

Treatment group takes Chinese medicine preparation of the present invention, get the Radix Astragali 22 grams, Rhizoma Dioscoreae 12 grams, Radix Angelicae Sinensis 12 grams, Pericarpium Citri Reticulatae 12 grams, Lignum Aquilariae Resinatum 12 grams, Exocarpium Citri Rubrum 12 grams, Rhizoma Curcumae 12 grams, the Radix Linderae 12 grams, Fructus Liquidambaris 12 grams, Ramulus Cinnamomi 9 grams, Spina Gleditsiae 9 grams, Squama Manis 9 grams, Caulis Sargentodoxae 9 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 9 grams, Herba Asari 9 grams, Radix Aconiti Lateralis Preparata 9 grams, traditionally medicine decocting method adds water fried, extracting juice 300ml, take for 2 times respectively at morning, evening point, every day 1 dose.The low dose of incremental treatment of matched group penicillamine, originally every day 0.15g, add dosage according to conditions of patients, give dexamethasone hormone, compound fruit acid, vitamin and benzazoline etc. simultaneously.Two groups was all 1 course for the treatment of with 1 month, judged curative effect after treating 3 courses for the treatment of.

Efficacy result:

1. clinical efficacy results contrast:

After treatment, treatment group cures 8 examples, effective 12 examples, effective 15 examples, invalid 5 examples, and cure rate is 20.0%, and effective percentage is 87.5%; Matched group cures 2 examples, effective 11 examples, effective 10 examples, invalid 13 examples, cure rate 5.60%, effective percentage 63.9%.The cure rate for the treatment of group, effective percentage are apparently higher than matched group, and between group, significantly (P < 0.05), have statistical significance, detailed results is in table 1 for comparing difference.

Table 1: clinical efficacy result synopsis after two groups of treatments

Group	Number of cases	Cure n (%)	Effective n (%)	Effective n (%)	Invalid n (%)	Total effective rate (%)
							Treatment group	40	8(20.0)	12(30.0)	15(37.5)	5(12.5)	87.5
Matched group	36	2(5.6)	11(30.60)	10(27.8)	13(36.1)	63.9

2. after liang group treatment, laboratory examination results compares:

After two groups of treatments, skin hardnesses and Raynaud phenomenon total score all decline to some extent than before treatment, and wherein to treat this sick curative effect more obvious for treatment group, and two groups of data are compared, and difference has significance (P < 0.05), and detailed results is in table 2.

Table 2: laboratory examination results comparison sheet after two groups of treatments

3. side effect performance:

Adding up two groups of patients side effect performance over the course for the treatment of, there is not obvious adverse reaction in treatment group, and matched group has 10 examples to occur xerostomia, drowsiness, dizzy, weak, and erythra appears in 5 examples, all after anti symptom treatment, does not affect treatment.

Result shows, Chinese medicine preparation of the present invention can debate disease treating, effectively hit pathogenesis, therefore compared with traditional western medicine method, treatment diffusivity systemic sclerosis has that instant effect, short treating period, cure rate are high, the advantage such as have no side effect, clinic promotion and application.

Detailed description of the invention

Embodiment 1: a kind of Chinese medicine preparation for the treatment of diffusivity systemic sclerosis, chooses the Radix Astragali 20 grams, Rhizoma Dioscoreae 10 grams, Radix Angelicae Sinensis 10 grams, Pericarpium Citri Reticulatae 10 grams, Lignum Aquilariae Resinatum 10 grams, Exocarpium Citri Rubrum 10 grams, Rhizoma Curcumae 10 grams, the Radix Linderae 10 grams, Fructus Liquidambaris 10 grams, Ramulus Cinnamomi 8 grams, Spina Gleditsiae 8 grams, Squama Manis 8 grams, Caulis Sargentodoxae 8 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 grams, Herba Asari 8 grams, Radix Aconiti Lateralis Preparata 8 grams.

Embodiment 2: a kind of Chinese medicine preparation for the treatment of diffusivity systemic sclerosis, chooses the Radix Astragali 22 grams, Rhizoma Dioscoreae 12 grams, Radix Angelicae Sinensis 12 grams, Pericarpium Citri Reticulatae 12 grams, Lignum Aquilariae Resinatum 12 grams, Exocarpium Citri Rubrum 12 grams, Rhizoma Curcumae 12 grams, the Radix Linderae 12 grams, Fructus Liquidambaris 12 grams, Ramulus Cinnamomi 9 grams, Spina Gleditsiae 9 grams, Squama Manis 9 grams, Caulis Sargentodoxae 9 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 9 grams, Herba Asari 9 grams, Radix Aconiti Lateralis Preparata 9 grams.

Embodiment 3: a kind of Chinese medicine preparation for the treatment of diffusivity systemic sclerosis, chooses the Radix Astragali 24 grams, Rhizoma Dioscoreae 14 grams, Radix Angelicae Sinensis 14 grams, Pericarpium Citri Reticulatae 14 grams, Lignum Aquilariae Resinatum 14 grams, Exocarpium Citri Rubrum 14 grams, Rhizoma Curcumae 14 grams, the Radix Linderae 14 grams, Fructus Liquidambaris 14 grams, Ramulus Cinnamomi 11 grams, Spina Gleditsiae 9 grams, Squama Manis 8 grams, Caulis Sargentodoxae 9 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 grams, Herba Asari 9 grams, Radix Aconiti Lateralis Preparata 8 grams.

Embodiment 4: a kind of Chinese medicine preparation for the treatment of diffusivity systemic sclerosis, chooses the Radix Astragali 26 grams, Rhizoma Dioscoreae 16 grams, Radix Angelicae Sinensis 16 grams, Pericarpium Citri Reticulatae 16 grams, Lignum Aquilariae Resinatum 16 grams, Exocarpium Citri Rubrum 16 grams, Rhizoma Curcumae 16 grams, the Radix Linderae 16 grams, Fructus Liquidambaris 16 grams, Ramulus Cinnamomi 13 grams, Spina Gleditsiae 10 grams, Squama Manis 10 grams, Caulis Sargentodoxae 10 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 10 grams, Herba Asari 10 grams, Radix Aconiti Lateralis Preparata 10 grams.

Embodiment 5: a kind of Chinese medicine preparation for the treatment of diffusivity systemic sclerosis, chooses the Radix Astragali 28 grams, Rhizoma Dioscoreae 18 grams, Radix Angelicae Sinensis 18 grams, Pericarpium Citri Reticulatae 18 grams, Lignum Aquilariae Resinatum 18 grams, Exocarpium Citri Rubrum 18 grams, Rhizoma Curcumae 18 grams, the Radix Linderae 18 grams, Fructus Liquidambaris 18 grams, Ramulus Cinnamomi 14 grams, Spina Gleditsiae 11 grams, Squama Manis 11 grams, Caulis Sargentodoxae 11 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 11 grams, Herba Asari 11 grams, Radix Aconiti Lateralis Preparata 11 grams.

Embodiment 6: a kind of Chinese medicine preparation for the treatment of diffusivity systemic sclerosis, chooses the Radix Astragali 30 grams, Rhizoma Dioscoreae 20 grams, Radix Angelicae Sinensis 20 grams, Pericarpium Citri Reticulatae 20 grams, Lignum Aquilariae Resinatum 20 grams, Exocarpium Citri Rubrum 20 grams, Rhizoma Curcumae 20 grams, the Radix Linderae 20 grams, Fructus Liquidambaris 20 grams, Ramulus Cinnamomi 15 grams, Spina Gleditsiae 12 grams, Squama Manis 8-12 gram, Caulis Sargentodoxae 12 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 12 grams, Herba Asari 12 grams, Radix Aconiti Lateralis Preparata 12 grams.

Below by concrete case, Chinese medicine preparation curative effect of the present invention is verified further:

Case 1

Fourth, man, 51 years old.Patient started before 2 years to occur both hands and forearm swelling, rear whole skin turns black gradually, hardening, the winter plays both hands and meets and coldly to turn white, send out cool, obtains hot flush, examination in hospital is examined as " systemic sclerosis ", and patient once oral skin health sheet, Glucosidorum Tripterygll Totorum, penicillamine etc. is invalid.Since morbidity, spiritlessness and weakness, cough, inappetence, labour or have palpitation after climbing building, breathe hard, skin pruritus, sleeps poor.Under friend recommendation, take Chinese medicine preparation of the present invention treatment, get the Radix Astragali 24 grams, Rhizoma Dioscoreae 14 grams, Radix Angelicae Sinensis 14 grams, Pericarpium Citri Reticulatae 14 grams, Lignum Aquilariae Resinatum 14 grams, Exocarpium Citri Rubrum 14 grams, Rhizoma Curcumae 14 grams, the Radix Linderae 14 grams, Fructus Liquidambaris 14 grams, Ramulus Cinnamomi 11 grams, Spina Gleditsiae 9 grams, Squama Manis 8 grams, Caulis Sargentodoxae 9 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 grams, Herba Asari 9 grams, Radix Aconiti Lateralis Preparata 8 grams, take after decocting, 2 times on the 1st, treat 3 months altogether, whole skin is completely softening, the colour of skin recovers normal, each joint motion is (but articulations digitorum manus still flexion deformity) freely, Raynaud's phenomenon disappears substantially, in high spirits, food is received good, uncomfortable without other, blood Visfatin, erythrocyte sedimentation rate, the check of every lab index such as skin hardness is normal, clinical cure.Effect of follow-up visit by telephone has no recurrence in 1 year.

Case 2

Neat certain, man, 35 years old, without obvious cause, patient occurred that both hands were met cold or excited rear appearance is pale, livid purple rear rubescent before 1 year, companion's finger-joint pain, numbness, once treated 1 month DeGrain at local hospital, the rear state of an illness increases the weight of gradually, both hands meet the cold livid purple exacerbation of symptoms that loses color, and attack times is also more and more frequent.And engender that whole body skin is swollen, firmly accompany pigmentation.Upon somebody's introduction, have exploratory psychology in arms to take Chinese medicine preparation of the present invention treatment, get the Radix Astragali 20 grams, Rhizoma Dioscoreae 10 grams, Radix Angelicae Sinensis 10 grams, Pericarpium Citri Reticulatae 10 grams, Lignum Aquilariae Resinatum 10 grams, Exocarpium Citri Rubrum 10 grams, Rhizoma Curcumae 10 grams, the Radix Linderae 10 grams, Fructus Liquidambaris 10 grams, Ramulus Cinnamomi 8 grams, Spina Gleditsiae 8 grams, Squama Manis 8 grams, Caulis Sargentodoxae 8 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8 grams, Herba Asari 8 grams, Radix Aconiti Lateralis Preparata 8 grams, take after decocting, 2 times on the 1st, treat 3 months, entire patient's cutaneous pigmentation and depigmentation obviously reduce, to dehisce and both hands limitation of activity symptom is significantly improved, skin comparatively treats front deliquescing, and skin elasticity increases.Patient cures after continuing to strengthen 1 course for the treatment of of treatment.Follow up a case by regular visits to so far, have no recurrence.

Case 3

Zheng, female, 44 years old, patient was hardening without the skin diffusivity blackening of the obvious inducement whole body before 1 year, and atrophy appearred in skin afterwards, and finger meets cold variable color, and local hospital gives treatment 1 month with " systemic lupus erythematosus (sle) ", has no positive effect.So take Chinese medicine preparation of the present invention treatment under friend recommendation, get the Radix Astragali 26 grams, Rhizoma Dioscoreae 16 grams, Radix Angelicae Sinensis 16 grams, Pericarpium Citri Reticulatae 16 grams, Lignum Aquilariae Resinatum 16 grams, Exocarpium Citri Rubrum 16 grams, Rhizoma Curcumae 16 grams, the Radix Linderae 16 grams, Fructus Liquidambaris 16 grams, Ramulus Cinnamomi 13 grams, Spina Gleditsiae 10 grams, Squama Manis 10 grams, Caulis Sargentodoxae 10 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 10 grams, Herba Asari 10 grams, Radix Aconiti Lateralis Preparata 10 grams, take after decocting, 2 times on the 1st, through bimestrial treatment, conditions of patients is controlled, tighten the skin hardened and slowly recover normal, the colour of skin is normal, dietary, face is gradually ruddy.Following the service 1 course for the treatment of, in addition after after treatment, patient fully recovered.Effect of follow-up visit by telephone has no recurrence half a year.

Claims

1. treat a Chinese medicine preparation for diffusivity systemic sclerosis, it is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:

2. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the raw material of following weight portion:

3. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the raw material of following weight portion:

4. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the raw material of following weight portion:

5. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the raw material of following weight portion:

6. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the raw material of following weight portion:

7. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the raw material of following weight portion: