CN105193962A - Traditional Chinese medicine composition for treating low back pain after lumbar discectomy - Google Patents

Abstract

The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine composition for treating low back pain after lumbar discectomy. The composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 20-30 parts of angelica sinensis, 2-4 parts of leech, 3-7 parts of radix of mirabilis jalapa, 6-14 parts of safflower carthamus, 11-19 parts of rhizoma cibotii, 4-8 parts of dockleaved knotweed herb root, 6-14 parts of myrrh, 6-14 parts of raw rhizoma atractylodis macrocephalae, 6-14 parts of liquidambar formosana hance, 4-8 parts of pseudo-ginseng powder and 5-13 parts of rhizoma corydalis, and the traditional Chinese medicinal materials are combined to achieve the effects of promoting blood circulation to remove stasis, dredging collaterals, diminishing swelling, tonifying kidneys, tonifying qi and promoting qi circulation to relieve pain. The traditional Chinese medicine composition has the advantages of high efficiency and low recurrence rate.

Description

A kind of Chinese medicine composition for the treatment of lumbago after lumbar intervertebral disc operation

Technical field

The invention belongs to medical art, be specifically related to a kind of Chinese medicine composition for the treatment of lumbago after lumbar intervertebral disc operation.

Background technology

After lumbar intervertebral disc operation, lumbago chronic back pain is clinical more common operative failure syndrome, is also face and one of open question for a long time.The all kinds pain symptom that Lumbar Disc herniation resection occurs, not only the cause of disease is complicated, difficult diagnosis, and processes thorny.Its cause the reason of pain to mainly contain discectomy is postoperative gives prominence to again, intraspinal tube epidural scarring hypertrophy, adhesion cause spinal dura mater and nerve root tractive, extruding, and spinal canal stenosis, lumbar instability, the factors such as autoimmune response, cause Lumbar pain after operation.Conventional nonsteroidal medicine and re-operation, the former clinical efficacy is not good or only have interim effect; The latter damages and misery is large and uncertain therapeutic efficacy is fixed, and patient is difficult to accept.

Summary of the invention

Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, provides a kind of Chinese medicine composition for the treatment of lumbago after lumbar intervertebral disc operation.

The present invention is achieved through the following technical solutions:

Treat a Chinese medicine composition for lumbago after lumbar intervertebral disc operation, be made up of the Chinese medicine of following weight portion:

Radix Angelicae Sinensis 20-30 part, Hirudo 2-4 part, Radix Mirabilis 3-7 part, Flos Carthami 6-14 part, Rhizoma Cibotii 11-19 part, Herba Polygoni nodosi 4-8 part, Myrrha 6-14 part, Rhizoma Atractylodis Macrocephalae 6-14 part, Fructus Liquidambaris 6-14 part, Radix Notoginseng powder 4-8 part, Rhizoma Corydalis 5-13 part.

Preferably, the Chinese medicine composition of lumbago after above-mentioned treatment lumbar intervertebral disc operation, is made up of the Chinese medicine of following weight portion:

Radix Angelicae Sinensis 23-27 part, Hirudo 2.5-3.5 part, Radix Mirabilis 4-6 part, Flos Carthami 8-12 part, Rhizoma Cibotii 13-17 part, Herba Polygoni nodosi 5-7 part, Myrrha 8-12 part, Rhizoma Atractylodis Macrocephalae 8-12 part, Fructus Liquidambaris 8-12 part, Radix Notoginseng powder 5-7 part, Rhizoma Corydalis 7-11 part.

Preferred, the Chinese medicine composition of lumbago after above-mentioned treatment lumbar intervertebral disc operation, is made up of the Chinese medicine of following weight portion:

Radix Angelicae Sinensis 25 parts, Hirudo 3 parts, Radix Mirabilis 5 parts, 10 parts, Flos Carthami, Rhizoma Cibotii 15 parts, Herba Polygoni nodosi 6 parts, Myrrha 10 parts, Rhizoma Atractylodis Macrocephalae 10 parts, Fructus Liquidambaris 10 parts, Radix Notoginseng powder 6 parts, Rhizoma Corydalis 9 parts.

The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.

The weight portion of said medicine, if in units of g, the normally consumption of 1 dose.

The indication of Chinese medicine of the present invention: be used for the treatment of lumbago after lumbar intervertebral disc operation.

The taboo item of Chinese medicine of the present invention: the fasting for the treatment of period in a medicine is greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food.

In Chinese medicine composition of the present invention,

Herba Polygoni nodosi is herb or the root of polygonaceae plant joint knotweed or campanilla knotweed." Traditional Chinese Medicine in Sichuan will ": " detumescence, dissipating blood stasis, removing blood stasis.Control innominate toxic swelling, carbuncle of yin nature, scrofula and the moon abdominal mass sick.”

Radix Mirabilis another name is spent ginseng, Steamed dumpling with pork，mushrooms and bamboo shoots root in vain, is entered DILAOSHU, pollen head, pigment head, powder head, kermes fresh idea, white lead root, white lead angle, be the root of Nyctaginaceae plant Mirabilis jalapa.Sweet in the mouth; Light; Cold nature.Function clearing away heat-damp and promoting diuresis; Removing toxic substances is invigorated blood circulation.Main pyretic stranguria; Nebulousurine; Edema; Leucorrhea with red and white discharge; Arthralgia; Carbuncle pyogenic infections from tumour or sore; Acute mastitis; Traumatic injury." Nanning City's medicine will ": antipyretic, laxation, removing blood stasis with potent drugs, regulating menstruation.Control impairment of the lung caused by overstrain hemoptysis.

In the prescription of Chinese medicine composition of the present invention, other medicines all record Chinese Pharmacopoeia 2010 editions.

The traditional Chinese medical science is thought, lumbar surgery consequential damage passages through which vital energy circulates, causes retention of blood stasis.Although can have distinguishing of the wet and cold and heat and asthenia and sthenia of folder expectorant, folder according to the body constitution of patient, stasis blocking passages through which vital energy circulates is that it is basic.Lumbar pain after operation is not from the stasis of blood, void, stagnant.Prolapse of lumbar intervertebral disc essence is that the empty natural endowment of deficiency of the kidney body is not enough, and fatigue too in addition, or weakness due to chronic disease, or worn with age, or sexual overstrain, so that deficiency of the kidney, is difficult moisten foster waist Fu Jinmai and lumbago occurs.In addition, in art, golden sword coup injury blood network, outside blood oozing from the body openings or subcuta neous tissue arteries and veins, causes obstruction of collaterals by blood stasis, fears before operation in patients to operation, postoperatively torments by pain, and how depressed feelings will is, and the stagnation of QI is obvious.Therefore, inventor thinks, blood stasis is the main pathogenesis of Lumbar Disc herniation resection lumbago, has deficiency of the kidney body concurrently empty, stagnation of QI and blood may bring about pain, treatment when subsiding a swelling with blood circulation promoting and blood stasis dispelling, dredging collateral, tonify Qi of the kidney, promoting the circulation of QI to relieve pain.

Chinese medicine composition of the present invention, its prescription mechanism is as follows: Radix Angelicae Sinensis blood circulation promoting and enriching, Hirudo, Radix Mirabilis removing blood stasis removing blood stasis with potent drugs; Flos Carthami is invigorated blood circulation; Rhizoma Cibotii invigorating the liver and kidney, except rheumatism, sharp joint; Herba Polygoni nodosi, Myrrha fall apart blood blood stasis removing, subduing swelling and relieving pain; Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI.Drying dampness to eliminate phlegm; Fructus Liquidambaris dredging collateral; The analgesic therapy of Radix Notoginseng powder dissipating blood stasis for subsidence of swelling; Rhizoma Corydalis promoting blood circulation to remove blood stasis, promoting the circulation of QI to relieve pain, full side plays blood circulation promoting and blood stasis dispelling altogether, dredging collateral is subsided a swelling, tonify Qi of the kidney, effect of promoting the circulation of QI to relieve pain.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.

Embodiment 1

Treat a Chinese medicine composition for lumbago after lumbar intervertebral disc operation, each crude drug weight proportion is as follows:

Radix Angelicae Sinensis 25g, Hirudo 3g, Radix Mirabilis 5g, Flos Carthami 10g, Rhizoma Cibotii 15g, Herba Polygoni nodosi 6g, Myrrha 10g, Rhizoma Atractylodis Macrocephalae 10g, Fructus Liquidambaris 10g, Radix Notoginseng powder 6g, Rhizoma Corydalis 9g.

Embodiment 2

Treat a Chinese medicine composition for lumbago after lumbar intervertebral disc operation, each crude drug weight proportion is as follows:

Radix Angelicae Sinensis 23 parts, Hirudo 3.5 parts, Radix Mirabilis 4 parts, 12 parts, Flos Carthami, Rhizoma Cibotii 13 parts, Herba Polygoni nodosi 7 parts, Myrrha 8 parts, Rhizoma Atractylodis Macrocephalae 12 parts, Fructus Liquidambaris 8 parts, Radix Notoginseng powder 7 parts, Rhizoma Corydalis 7 parts.

Embodiment 3

Treat a Chinese medicine composition for lumbago after lumbar intervertebral disc operation, each crude drug weight proportion is as follows:

Radix Angelicae Sinensis 27 parts, Hirudo 2.5 parts, Radix Mirabilis 6 parts, 8 parts, Flos Carthami, Rhizoma Cibotii 17 parts, Herba Polygoni nodosi 5 parts, Myrrha 12 parts, Rhizoma Atractylodis Macrocephalae 8 parts, Fructus Liquidambaris 12 parts, Radix Notoginseng powder 5 parts, Rhizoma Corydalis 11 parts.

Embodiment 4

Treat a Chinese medicine composition for lumbago after lumbar intervertebral disc operation, each crude drug weight proportion is as follows:

Radix Angelicae Sinensis 20 parts, Hirudo 4 parts, Radix Mirabilis 3 parts, 14 parts, Flos Carthami, Rhizoma Cibotii 11 parts, Herba Polygoni nodosi 8 parts, Myrrha 6 parts, Rhizoma Atractylodis Macrocephalae 14 parts, Fructus Liquidambaris 6 parts, Radix Notoginseng powder 8 parts, Rhizoma Corydalis 5 parts.

Embodiment 5

Treat a Chinese medicine composition for lumbago after lumbar intervertebral disc operation, each crude drug weight proportion is as follows:

Radix Angelicae Sinensis 30 parts, Hirudo 2 parts, Radix Mirabilis 7 parts, 6 parts, Flos Carthami, Rhizoma Cibotii 19 parts, Herba Polygoni nodosi 4 parts, Myrrha 14 parts, Rhizoma Atractylodis Macrocephalae 6 parts, Fructus Liquidambaris 14 parts, Radix Notoginseng powder 4 parts, Rhizoma Corydalis 13 parts.

Carried out clinical pharrnacokinetics test to Chinese medicine composition of the present invention, Details as Follows:

1 clinical data

1.1 case selections: 78 routine cases all have prolapse of lumbar intervertebral disc, straitness of lumbar vertebrae or lumbar spondylolisthesis and accept lumbar surgery medical history.Get rid of: 1. have other chronic diseases that can cause lumbago and skelalgia and severe cardiac, brain, liver, kidney diaseases patient; 2. other operators beyond lumbar vertebra were once accepted; 3. the obvious dyskinesia person of lower limb.

1.2 physical data: 78 routine patients are divided into 2 groups at random.Treatment group 41 example, man 17 example, female 24 example; 38-65 years old ages, average (49.2 ± 3.2) year; The course of disease May ~ 12 years.Matched group 37 example, man 16 example, female 21 example; 39 ~ 67 years old age, average (40.4 ± 2.8) year; Course of disease April ~ 10 year.2 groups of case sexes, age, course of disease difference there are no significant meaning (P>0.05).

2 Therapeutic Method

2.1 treatment groups: the extract oral giving the embodiment of the present invention 1, one day 1 dose, be decocted in water for oral dose (wherein Radix Notoginseng powder is not decocted, and directly takes after mixing it with water) one day twice, sub-service sooner or later.

2.2 matched groups: each 50mg of diclofenac sodium, every day 3 times is oral.Person notes protecting stomach gastrointestinal reaction.

2 groups equal 4 weeks be 1 course for the treatment of.

3 observation of curative effect

3.1 criterions of therapeutical effect are cured: lumbago and skelalgia transference cure, and function recovers normal substantially; Take a turn for the better: lumbago and skelalgia alleviates, and still has pain after fatigue; Invalid: symptom, sign are without improvement.

3.2 therapeutic outcome

3.2.1 two groups of short term effects compare: in table 1.

A table 1 liang group short term effect compares

Group	n	Cure	Take a turn for the better	Invalid	Cure rate (%)	Total effective rate (%)
							Treatment group	41	24	15	3	58.54*	95.12**
Matched group	37	16	8	13	43.24	64.86

Note: * and matched group P < 0.05, * * and matched group P < 0.01.

3.2.2 two groups of late results compare: carry out following up a case by regular visits to for 1 year to healing, improvement case, the results are shown in Table 2.

A table 2 liang group late result compares

Group	n	Recurrence	Relapse rate
				Treatment group	39	2	5.12
Matched group	24	10	41.67**

Note: * * and matched group P < 0.01.

Claims (3)

1. treat a Chinese medicine composition for lumbago after lumbar intervertebral disc operation, be made up of the Chinese medicine of following weight portion:

Radix Angelicae Sinensis 20-30 part, Hirudo 2-4 part, Radix Mirabilis 3-7 part, Flos Carthami 6-14 part, Rhizoma Cibotii 11-19 part, Herba Polygoni nodosi 4-8 part, Myrrha 6-14 part, Rhizoma Atractylodis Macrocephalae 6-14 part, Fructus Liquidambaris 6-14 part, Radix Notoginseng powder 4-8 part, Rhizoma Corydalis 5-13 part.

2. the Chinese medicine composition of lumbago after treatment lumbar intervertebral disc operation according to claim 2, is characterized in that, be made up of the Chinese medicine of following weight portion:

Radix Angelicae Sinensis 23-27 part, Hirudo 2.5-3.5 part, Radix Mirabilis 4-6 part, Flos Carthami 8-12 part, Rhizoma Cibotii 13-17 part, Herba Polygoni nodosi 5-7 part, Myrrha 8-12 part, Rhizoma Atractylodis Macrocephalae 8-12 part, Fructus Liquidambaris 8-12 part, Radix Notoginseng powder 5-7 part, Rhizoma Corydalis 7-11 part.

3. the Chinese medicine composition of lumbago after treatment lumbar intervertebral disc operation according to claim 2, is characterized in that, be made up of the Chinese medicine of following weight portion:

Radix Angelicae Sinensis 25 parts, Hirudo 3 parts, Radix Mirabilis 5 parts, 10 parts, Flos Carthami, Rhizoma Cibotii 15 parts, Herba Polygoni nodosi 6 parts, Myrrha 10 parts, Rhizoma Atractylodis Macrocephalae 10 parts, Fructus Liquidambaris 10 parts, Radix Notoginseng powder 6 parts, Rhizoma Corydalis 9 parts.