CN108066738B

CN108066738B - Ointment for treating gouty arthritis and preparation method thereof

Info

Publication number: CN108066738B
Application number: CN201810148445.2A
Authority: CN
Inventors: 谢晓龙; 谢忠文; 王海亮
Original assignee: Meishan Traditional Chinese Medicine Hospital
Current assignee: Meishan Traditional Chinese Medicine Hospital
Priority date: 2018-02-13
Filing date: 2018-02-13
Publication date: 2021-02-05
Anticipated expiration: 2038-02-13
Also published as: CN108066738A

Abstract

The invention discloses an ointment for treating gouty arthritis and a preparation method thereof, relates to the technical field of traditional Chinese medicines, and solves the problems that the existing western medicines are not strong in capacity of treating gouty arthritis and hard to eliminate tissue swelling. Comprises vaseline and is characterized by also comprising the following components: the traditional Chinese medicine ointment is prepared from raw kusnezoff monkshood root, pollen, golden cypress, turmeric, angelica root, officinal magnolia bark, tangerine peel, raw arisaema tuber, rhizoma atractylodis, raw liquorice, radix angelicae pubescentis, fineleaf schizonepeta herb, mint, natural indigo, Indian iphigenia bulb, rhubarb, gardenia, amur corktree bark, baical skullcap root, rhizoma paridis, kudzuvine root, turmeric root-tuber, pseudo-ginseng, borneol, magnesium sulfate, vaseline, ichthyol and ginger.

Description

Ointment for treating gouty arthritis and preparation method thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to an ointment for treating gouty arthritis and a preparation method thereof.

Background

The ointment is an important component in the Chinese medicine and is one of five Chinese medicine dosage forms, i.e., pill, powder, ointment, pellet and soup. The ointment therapy is a unique traditional Chinese medicine external therapy in traditional Chinese medicine, has two thousand years of history, is widely applied to treating various diseases, and is deeply popular with the masses. The medicament is applied to the body surface or the affected part of a patient, and the functions of promoting blood circulation, removing blood stasis, promoting granulation, relieving pain, dredging channels, inducing resuscitation, penetrating bones, expelling wind and removing cold are exerted by the absorption of the medicament by the body surface and the channels and collaterals, so that the purposes of various treatment effects are achieved.

Gouty arthritis is generally manifested as red, swollen, hot and painful, mainly because urate crystals stimulate peripheral tissues and stimulate the release of inflammatory factors, thereby causing acute attack of gout inflammation. Local tissues in the early stage of inflammation only show general congestion, edema and the like, and then the inflammatory reaction is gradually increased along with the time, and even the inflammatory reaction spreads to the whole body; the persistent exacerbation of the inflammatory reaction can form a vicious circle, thereby influencing the recovery of inflammation; the main measures of western medicine for acute attack of gout inflammation include: the application of antipyretic analgesic medicine is local cold compress, but only aims at acute red, hot and pain symptoms, and is difficult to achieve the effect of eliminating tissue swelling;

how to solve the problems that the existing western medicines are not strong in the ability to treat gouty arthritis and difficult to eliminate tissue swelling becomes the direction of research of technical personnel in the field.

Disclosure of Invention

The invention aims to: the existing western medicines are not strong in capacity of treating gouty arthritis and are difficult to eliminate the problem of tissue swelling, and the ointment for treating gouty arthritis is provided.

The invention specifically adopts the following technical scheme for realizing the purpose:

an ointment for treating gouty arthritis comprises vaseline and also comprises the following components: radix Aconiti Kusnezoffii, pollen, cortex Phellodendri, Curcuma rhizome, radix Angelicae Dahuricae, cortex Magnolia officinalis, pericarpium Citri Tangerinae, rhizoma arisaematis, rhizoma Atractylodis, Glycyrrhrizae radix, radix Angelicae Pubescentis, herba Schizonepetae, herba Menthae, indigo naturalis, Pseudobulbus Cremastrae seu pleiones, radix et rhizoma Rhei, fructus Gardeniae, cortex Phellodendri, Scutellariae radix, rhizoma paridis, radix Puerariae, radix Curcumae, Notoginseng radix, Borneolum Syntheticum, magnesium sulfate, vaseline, ichthammol and rhizoma Zingiberis recens.

Further, the ointment for treating gouty arthritis is prepared from the following raw materials in parts by weight: 210 parts of Vaseline 185-containing material, 10-15 parts of raw kusnezoff monkshood root, 20-35 parts of pollen, 12-20 parts of golden cypress, 7-12 parts of turmeric, 8-13 parts of angelica dahurica, 10-15 parts of mangnolia officinalis, 10-15 parts of dried orange peel, 10-20 parts of raw arisaema tuber, 10-15 parts of rhizoma atractylodis, 10-15 parts of raw licorice, 10-20 parts of radix angelicae pubescentis, 10-15 parts of schizonepeta, 10-18 parts of mint, 10-20 parts of indigo naturalis, 10-18 parts of Indian iphigenia bulb, 8-15 parts of rhubarb, 10-18 parts of gardenia, 10-20 parts of golden cypress, 10-16 parts of scutellaria baicalensis, 10-15 parts of rhizoma paridis, 8-15 parts of radix puerariae, 8-15 parts of radix curcumae, 15-30 parts of pseudo-ginseng, 40-60 parts of borneol, 25-40.

Further, the ointment for treating gouty arthritis is prepared from the following raw materials in parts by weight: 200 parts of vaseline 185-containing material, 10-12 parts of raw kusnezoff monkshood root, 25-35 parts of pollen, 12-16 parts of golden cypress, 7-10 parts of turmeric, 8-10 parts of angelica dahurica, 10-12 parts of mangnolia officinalis, 10-12 parts of dried orange peel, 10-15 parts of raw arisaema tuber, 10-13 parts of rhizoma atractylodis, 10-13 parts of raw liquorice, 10-15 parts of radix angelicae pubescentis, 10-13 parts of schizonepeta, 10-15 parts of mint, 10-15 parts of indigo naturalis, 10-15 parts of edible tulip, 8-12 parts of rheum officinale, 10-15 parts of cape jasmine, 10-15 parts of golden cypress, 10-15 parts of scutellaria baicalensis, 12-15 parts of paris polyphylla rhizome, 8-11 parts of radix puerariae, 8-12 parts of radix curcumae, 15-25 parts of pseudo-ginseng, 45-55 parts of borneol, 25-.

Further, the ointment for treating gouty arthritis is prepared from the following raw materials in parts by weight: 200 parts of vaseline, 12 parts of raw kusnezoff monkshood root, 30 parts of pollen, 15 parts of golden cypress, 10 parts of turmeric, 10 parts of angelica dahurica, 12 parts of mangnolia officinalis, 12 parts of dried orange peel, 12 parts of raw arisaema tuber, 12 parts of rhizoma atractylodis, 12 parts of raw liquorice, 12 parts of radix angelicae pubescentis, 12 parts of schizonepeta, 12 parts of mint, 12 parts of indigo naturalis, 12 parts of edible tulip, 10 parts of rheum officinale, 13 parts of cape jasmine, 13 parts of golden cypress, 13 parts of scutellaria baicalensis, 13 parts of rhizoma paridis, 10 parts of radix puerariae, 10 parts of radix curcumae, 20 parts of pseudo-ginseng, 50 parts of borneol.

The raw materials of the invention have the following pharmacological actions:

rhizoma arisaematis: bitter, pungent and warm; is toxic. It enters lung, liver and spleen meridians. Has the effects of eliminating dampness and phlegm, dispelling pathogenic wind and relieving spasm, and resolving hard mass and swelling.

Raw kusnezoff monkshood root: pungent, bitter and hot; it is toxic. It enters heart, liver, kidney and spleen meridians. Has the effects of dispelling pathogenic wind, removing dampness, relieving inflammation and relieving pain.

Pollen: sweet, slightly bitter and slightly cold in taste; entering lung and stomach meridians; has the effects of clearing heat, purging fire, relieving swelling and expelling pus.

Phellodendron bark: bitter and cold. Entering kidney, bladder and large intestine meridians; has the effects of clearing heat, eliminating dampness, purging fire, removing toxin, and removing bone-steaming.

Turmeric: is bitter in taste; warm in nature, entering spleen meridian; the liver meridian. Can break blood and promote qi circulation; induce menstruation to relieve menalgia.

Radix angelicae: pungent taste and warm nature; entering lung, stomach and large intestine meridians; relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, eliminating dampness, stopping leukorrhagia, and relieving swelling and pus discharge;

magnolia officinalis: bitter, pungent and warm; the spleen, stomach, lung and large intestine meridians entered; the function is to eliminate dampness and phlegm, and to lower qi and remove fullness;

dried orange peel: pungent, bitter and warm; spleen and lung meridian entered; has the functions of regulating qi, strengthening spleen, eliminating dampness and reducing phlegm;

rhizoma atractylodis: pungent, bitter and warm; spleen, stomach and liver meridians entered; the functions of eliminating dampness, strengthening spleen, dispelling wind and dispelling cold;

raw licorice root: sweet and mild; entering heart, lung, spleen and stomach meridians; has the functions of invigorating spleen and replenishing qi, eliminating phlegm and relieving cough, relieving spasm and pain, clearing away heat and toxic material and harmonizing the drugs.

Radix angelicae pubescentis: pungent, bitter and slightly warm; entering kidney and bladder meridians; has the functions of dispelling wind-damp, relieving pain and relieving exterior syndrome.

Herba schizonepetae: pungent and mild-warm; entering lung and liver meridians; expelling pathogenic wind, relieving exterior syndrome, promoting eruption, eliminating sore, and stopping bleeding.

Mint: pungent and cool; entering lung and liver meridians; has the functions of dispelling wind and heat, clearing head and eyes, relieving sore throat and promoting eruption, and soothing liver and promoting qi circulation.

Indigo naturalis: salty and sweet; entering liver and lung meridians; has the functions of clearing away heat and toxic material, cooling blood and eliminating macula, clearing liver-fire and arresting convulsion.

And (3) edible tulip: sweet, slightly pungent and cool; entering liver and spleen meridians; has the functions of clearing away heat and toxic material, eliminating carbuncle and dissipating nodulation.

Rhubarb: bitter and cold; spleen, stomach, large intestine, liver, pericardium meridian entered; has the functions of purging and eliminating accumulation, clearing heat and purging fire, cooling blood and removing toxicity, and removing blood stasis and stimulating the menstrual flow.

Gardenia: bitter and cold; heart, lung and triple energizer meridians entered; has the functions of purging fire, relieving restlessness, clearing heat, promoting diuresis, cooling blood and removing toxicity.

Scutellaria baicalensis: bitter and cold; it enters lung, gallbladder, spleen, stomach, large intestine and small intestine meridians; has the functions of clearing heat, drying dampness, purging fire, removing toxicity, stopping bleeding and preventing miscarriage.

Rhizoma paridis: bitter and slightly cold; entering liver meridian; has the functions of clearing away heat and toxic material, eliminating swelling, relieving pain, cooling liver and arresting convulsion.

Kudzu root: sweet, pungent and cool; spleen and stomach meridians entered; has the functions of expelling pathogenic factors from muscles, allaying fever, promoting eruption, promoting the production of body fluid to quench thirst, invigorating yang and relieving diarrhea.

Turmeric root-tuber: pungent, bitter and cold; it enters liver, gallbladder and heart meridians; has the functions of promoting blood circulation to arrest pain, promoting qi circulation to relieve depression, clearing away heart-fire, cooling blood, benefiting gallbladder and eliminating jaundice.

Pseudo-ginseng: sweet, slightly bitter and warm; entering liver and stomach meridians; has the functions of dispersing blood stasis, stopping bleeding, promoting blood circulation and relieving pain.

Borneol: pungent, bitter and slightly cold; it enters heart, spleen and lung meridians. Has the effects of inducing resuscitation, refreshing mind, clearing heat and relieving pain.

Magnesium sulfate: the dehydrating agent has the functions of inhibiting the center and relaxing skeletal muscles; can be used for treating swelling after limb trauma and improving rough skin.

Methyl salicylate: promoting local blood circulation, and reflectively affecting skin, muscle, nerve and joint at corresponding parts, thereby having antiinflammatory, analgesic and antipruritic effects.

Ichthyol: has effects of disinfecting, antisepticising, relieving inflammation and antisepticising, and inhibiting secretion.

Vaseline: preserving corrosion and preserving moisture.

Ginger: pungent taste and warm nature; has antibacterial, anticancer, antioxidant and antiaging effects.

The invention also aims to provide a preparation method of the ointment for treating gouty arthritis, which solves the problems that the existing western medicines are not strong in the ability of treating gouty arthritis and difficult to eliminate tissue swelling, and comprises the following steps:

(1) sun drying equal parts of radix Aconiti Kusnezoffii and rhizoma arisaematis, slicing, pulverizing into 45-55 mesh powder, mixing with succus Zingiberis recens, standing at 10-20 deg.C, removing juice, and air drying;

(2) dissolving vaseline in equal parts of boiled water, stirring uniformly, adding the mixture dried in the step (1), and stirring uniformly;

(3) respectively pulverizing Borneolum Syntheticum and magnesium sulfate to 95-105 mesh, adding into the solution obtained in step (2), and stirring;

(4) adding ichthyol and methyl salicylate into the solution obtained in step (3), maintaining the temperature at 70-80 deg.C, and stirring;

(5) mixing the raw materials of other components in proportion, grinding into fine powder to 490-510 meshes, adding the fine powder into the solution obtained in the step (4), and uniformly stirring;

(6) the medicine is placed in a special container and sealed for more than 40 hours, and the ointment for treating the gouty arthritis is obtained.

Further, the raw kusnezoff monkshood root and the raw arisaema tuber in the step (1) are ground into powder of 45-55 meshes and then mixed with ginger juice according to the proportion of 1: 3.

Further, the standing time of the mixed solution in the step (1) is 45 hours.

Further, the temperature of the mixed solution is controlled to be 80 ℃ in the process of dissolving the vaseline in equal parts of boiled water in the step (2).

The ointment prepared from the traditional Chinese medicine components plays a role through skin, on one hand, the reasonable compatibility of the traditional Chinese medicines is selected according to the treatment based on syndrome differentiation of the traditional Chinese medicine, the functions and the indications of each traditional Chinese medicine are fully utilized, and the good effect of the medicine is achieved. The ointment is directly applied to the body surface, and can penetrate into the skin to reach the channels and viscera, thereby regulating qi and blood, dredging channels and collaterals, dispelling cold and dampness, and eliminating swelling and pain. The traditional Chinese medicine surgical ointment is a large compound of a plurality of medicines by applying the channel tropism principle of traditional Chinese medicines and the efficiency of mutual coordination of the medicines, so as to exert good effects of the medicines. The ointment is used for a thin plaster on the skin surface, thick-smelled medicines are taken out from the ointment, and the medicines are introduced to lead the medicine to the group, so as to resolve the stagnation and lead the stagnation to the focus. Therefore, the medicine can permeate into the skin to produce the effects of diminishing inflammation, relieving pain, promoting blood circulation to disperse blood clots, clearing and activating the channels and collaterals, inducing resuscitation and penetrating bones, dispelling wind and cold and the like. The ointment applied on body surface stimulates nerve endings, expands blood vessels through reflection, promotes local blood circulation, improves peripheral tissue nutrition, and achieves the purposes of detumescence, antiphlogosis and analgesia. Meanwhile, the medicine permeates to subcutaneous tissues at the affected part through the skin and generates relative advantage of medicine concentration at local parts, thereby exerting stronger pharmacological action. Because water is required in the preparation of the ointment, if the prevention and treatment time of the ointment is too long, the medicine is deteriorated, and a preservative can be added in the preparation process; some highly irritant drugs in the ointment may cause strong irritation to the skin, which causes local histamine and other inflammatory mediators to induce inflammatory cells to release inflammatory factors, resulting in local skin allergy, so that some antiallergic agents are required to be added to improve the local skin antiallergic capability. The topical drug treatment can inhibit local inflammatory reaction, and can penetrate skin and mucous membrane, enter systemic circulation via blood vessel or lymphatic vessel, and generate systemic drug effect.

In summary, due to the adoption of the technical scheme, the invention has the beneficial effects that:

1. the ointment disclosed by the invention is convenient to use, safe and small in side effect, adopts an external treatment method to treat local inflammatory reaction, can be absorbed through skin, enables the effective concentration of local medicines to be obviously higher than blood concentration, and exerts obvious curative effect, adopts different components and medicinal materials with different medicinal properties to carry out scientific compatibility, and all the medicines play the effects of promoting blood circulation to remove blood stasis, dredging collaterals, relieving swelling and pain, and relaxing tendons and activating collaterals together. The formula can rapidly relieve pain symptoms caused by gouty arthritis within 1-2 hours, has an obvious inhibiting effect on inflammatory reaction around joints caused by the gouty arthritis, and achieves an obvious detumescence effect within 24-48 hours. Compared with the external preparation on the market at present, the medicine allergy probability is obviously reduced.

2. A large amount of ichthyol and methyl salicylate in the medicine belong to oily media, and the problem of reduced efficacy caused by rapid drying after the medicine is externally applied is effectively solved. The formula has good antiseptic effect and no other antiseptic is added.

3. The prescription and the preparation method promote the transdermal property of the medicine and effectively improve the medicine effect; meanwhile, borneol and magnesium sulfate in the formula cooperate to form a hypertonic state of the medicine, so that the detumescence effect is effectively improved.

4. The preparation method adopted by the invention is simple and is beneficial to industrial large-scale production. The ointment for treating gouty arthritis prepared by the method has the advantages that the ointment components are uniformly mixed, and the effect of the traditional Chinese medicine components of each component is favorably exerted.

Detailed Description

For a better understanding of the present invention by those skilled in the art, the present invention is further described in detail below with reference to the following examples:

Preferably, the ointment for treating gouty arthritis is prepared from the following raw materials in parts by weight: 210 parts of Vaseline 185-containing material, 10-15 parts of raw kusnezoff monkshood root, 20-35 parts of pollen, 12-20 parts of golden cypress, 7-12 parts of turmeric, 8-13 parts of angelica dahurica, 10-15 parts of mangnolia officinalis, 10-15 parts of dried orange peel, 10-20 parts of raw arisaema tuber, 10-15 parts of rhizoma atractylodis, 10-15 parts of raw licorice, 10-20 parts of radix angelicae pubescentis, 10-15 parts of schizonepeta, 10-18 parts of mint, 10-20 parts of indigo naturalis, 10-18 parts of Indian iphigenia bulb, 8-15 parts of rhubarb, 10-18 parts of gardenia, 10-20 parts of golden cypress, 10-16 parts of scutellaria baicalensis, 10-15 parts of rhizoma paridis, 8-15 parts of radix puerariae, 8-15 parts of radix curcumae, 15-30 parts of pseudo-ginseng, 40-60 parts of borneol, 25-40.

Preferably, the ointment for treating gouty arthritis is prepared from the following raw materials in parts by weight: 200 parts of vaseline 185-containing material, 10-12 parts of raw kusnezoff monkshood root, 25-35 parts of pollen, 12-16 parts of golden cypress, 7-10 parts of turmeric, 8-10 parts of angelica dahurica, 10-12 parts of mangnolia officinalis, 10-12 parts of dried orange peel, 10-15 parts of raw arisaema tuber, 10-13 parts of rhizoma atractylodis, 10-13 parts of raw liquorice, 10-15 parts of radix angelicae pubescentis, 10-13 parts of schizonepeta, 10-15 parts of mint, 10-15 parts of indigo naturalis, 10-15 parts of edible tulip, 8-12 parts of rheum officinale, 10-15 parts of cape jasmine, 10-15 parts of golden cypress, 10-15 parts of scutellaria baicalensis, 12-15 parts of paris polyphylla rhizome, 8-11 parts of radix puerariae, 8-12 parts of radix curcumae, 15-25 parts of pseudo-ginseng, 45-55 parts of borneol, 25-.

Preferably, the ointment for treating gouty arthritis is prepared from the following raw materials in parts by weight: 200 parts of vaseline, 12 parts of raw kusnezoff monkshood root, 30 parts of pollen, 15 parts of golden cypress, 10 parts of turmeric, 10 parts of angelica dahurica, 12 parts of mangnolia officinalis, 12 parts of dried orange peel, 12 parts of raw arisaema tuber, 12 parts of rhizoma atractylodis, 12 parts of raw liquorice, 12 parts of radix angelicae pubescentis, 12 parts of schizonepeta, 12 parts of mint, 12 parts of indigo naturalis, 12 parts of edible tulip, 10 parts of rheum officinale, 13 parts of cape jasmine, 13 parts of golden cypress, 13 parts of scutellaria baicalensis, 13 parts of rhizoma paridis, 10 parts of radix puerariae, 10 parts of radix curcumae, 20 parts of pseudo-ginseng, 50 parts of borneol.

The embodiment also provides a preparation method of the ointment for treating gouty arthritis, which comprises the following steps:

(5) mixing the raw materials of other components in proportion, grinding into fine powder of 490-510 meshes, checking the absence of running water and the absence of dripping water after stirring uniformly, adding the mixture into the solution obtained in the step (4) after the preliminary preparation is finished, and stirring uniformly;

Preferably, the raw kusnezoff monkshood root and the raw arisaema tuber in the step (1) are ground into powder of 45-55 meshes and then mixed with the ginger juice according to the proportion of 1: 3.

Preferably, the standing time of the mixed solution in the step (1) is 45 hours.

Preferably, the temperature of the mixed solution is controlled at 80 ℃ during the process of dissolving the vaseline in an equal part of boiled water in the step (2).

Example 1:

an ointment for treating gouty arthritis is prepared from the following raw materials in parts by weight: 185 parts of vaseline, 15 parts of raw kusnezoff monkshood root, 20 parts of pollen, 20 parts of golden cypress, 7 parts of turmeric, 13 parts of angelica dahurica, 10 parts of mangnolia officinalis, 15 parts of dried orange peel, 10 parts of raw arisaema tuber, 15 parts of rhizoma atractylodis, 10 parts of raw liquorice, 20 parts of radix angelicae pubescentis, 10 parts of schizonepeta, 18 parts of mint, 10 parts of indigo naturalis, 18 parts of edible tulip, 8 parts of rheum officinale, 18 parts of cape jasmine, 10 parts of golden cypress, 16 parts of scutellaria baicalensis, 10 parts of rhizoma paridis, 15 parts of radix puerariae, 8 parts of radix curcumae, 30 parts of pseudo-ginseng, 40 parts of borneol.

The embodiment also provides a preparation method of the ointment for treating gouty arthritis, which comprises the following steps of weighing the following materials in parts by weight:

(1) sun drying equal parts of radix Aconiti Kusnezoffii and rhizoma arisaematis, slicing, pulverizing into 45 mesh powder, mixing with succus Zingiberis recens, standing at 10 deg.C, removing juice, and air drying;

(3) respectively pulverizing Borneolum Syntheticum and magnesium sulfate to 105 mesh, adding into the solution obtained in step (2), and stirring;

(4) adding ichthyol and methyl salicylate into the solution obtained in the step (3), keeping the temperature at 70 ℃, and stirring uniformly;

(5) mixing the raw materials of other components in proportion, grinding into fine powder of 510 meshes, adding the fine powder into the solution obtained in the step (4), and uniformly stirring; after the mixture is uniformly stirred, checking the water-free state and the water-dripping-free state, and finishing the primary preparation;

Preferably, the raw kusnezoff monkshood root and the raw arisaema tuber in the step (1) are ground into 45 meshes and then mixed with the ginger juice according to the proportion of 1: 3.

Example 2:

an ointment for treating gouty arthritis is prepared from the following raw materials in parts by weight: 210 parts of vaseline, 10 parts of raw kusnezoff monkshood root, 35 parts of pollen, 12 parts of golden cypress, 12 parts of turmeric, 8 parts of angelica dahurica, 15 parts of mangnolia officinalis, 10 parts of dried orange peel, 20 parts of raw arisaema tuber, 10 parts of rhizoma atractylodis, 15 parts of raw liquorice, 10 parts of radix angelicae pubescentis, 15 parts of schizonepeta, 10 parts of mint, 20 parts of indigo naturalis, 10 parts of edible tulip, 15 parts of rheum officinale, 10 parts of cape jasmine, 20 parts of golden cypress, 10 parts of scutellaria baicalensis, 15 parts of rhizoma paridis, 8 parts of radix puerariae, 15 parts of radix curcumae, 15 parts of pseudo-ginseng, 60 parts of borneol.

(1) sun drying equal parts of radix Aconiti Kusnezoffii and rhizoma arisaematis, slicing, pulverizing into 55 mesh powder, mixing with succus Zingiberis recens, standing at 20 deg.C, removing juice, and air drying;

(3) respectively pulverizing Borneolum Syntheticum and magnesium sulfate to 95 mesh, adding into the solution obtained in step (2), and stirring;

(4) adding ichthyol and methyl salicylate into the solution obtained in the step (3), keeping the temperature at 80 ℃, and stirring uniformly;

(5) mixing the raw materials of other components in proportion, grinding into fine powder to 490 meshes, adding the fine powder into the solution obtained in the step (4), and uniformly stirring; after the mixture is uniformly stirred, checking the water-free state and the water-dripping-free state, and finishing the primary preparation;

(6) the medicine is placed in a special container and sealed for more than 45 hours, and the ointment for treating the gouty arthritis is obtained.

Preferably, the raw kusnezoff monkshood root and the raw arisaema tuber in the step (1) are ground into powder of 55 meshes and then mixed with the ginger juice according to the proportion of 1: 3.

Preferably, the standing time of the mixed solution in the step (1) is 48 hours.

Example 3:

an ointment for treating gouty arthritis is prepared from the following raw materials in parts by weight: 200 parts of vaseline, 10 parts of raw kusnezoff monkshood root, 35 parts of pollen, 12 parts of golden cypress, 10 parts of turmeric, 8 parts of angelica dahurica, 12 parts of mangnolia officinalis, 10 parts of dried orange peel, 15 parts of raw arisaema, 10 parts of rhizoma atractylodis, 13 parts of raw liquorice, 10 parts of radix angelicae pubescentis, 13 parts of schizonepeta, 10 parts of mint, 15 parts of indigo naturalis, 10 parts of edible tulip, 12 parts of rheum officinale, 10 parts of gardenia, 15 parts of golden cypress, 10 parts of scutellaria baicalensis, 15 parts of rhizoma paridis, 8 parts of radix puerariae, 12 parts of radix curcumae, 15 parts of pseudo-ginseng, 55 parts of borneol, 25.

(1) sun drying equal parts of radix Aconiti Kusnezoffii and rhizoma arisaematis, slicing, pulverizing into 50 mesh powder, mixing with succus Zingiberis recens, standing at 18 deg.C, removing juice, and air drying;

(3) respectively pulverizing Borneolum Syntheticum and magnesium sulfate to 100 mesh, adding into the solution obtained in step (2), and stirring;

(4) adding ichthyol and methyl salicylate into the solution obtained in the step (3), keeping the temperature at 75 ℃, and stirring uniformly;

(5) mixing the raw materials of other components in proportion, grinding into fine powder to 500 meshes, adding the fine powder into the solution obtained in the step (4), and uniformly stirring; after the mixture is uniformly stirred, checking the water-free state and the water-dripping-free state, and finishing the primary preparation;

(6) the medicine is placed in a special container and sealed for more than 48 hours, and the ointment for treating the gouty arthritis is obtained.

Preferably, the raw kusnezoff monkshood root and the raw arisaema tuber in the step (1) are ground into powder of 50 meshes and then mixed with the ginger juice according to the proportion of 1: 3.

Example 4:

an ointment for treating gouty arthritis is prepared from the following raw materials in parts by weight: 185 parts of vaseline, 12 parts of raw kusnezoff monkshood root, 25 parts of pollen, 16 parts of golden cypress, 7 parts of turmeric, 10 parts of angelica dahurica, 10 parts of mangnolia officinalis, 12 parts of dried orange peel, 10 parts of raw arisaema tuber, 13 parts of rhizoma atractylodis, 10 parts of raw liquorice, 15 parts of radix angelicae pubescentis, 10 parts of schizonepeta, 15 parts of mint, 10 parts of indigo naturalis, 15 parts of edible tulip, 8 parts of rheum officinale, 15 parts of cape jasmine, 10 parts of golden cypress, 15 parts of scutellaria baicalensis, 12 parts of paris polyphylla, 11 parts of radix puerariae, 8 parts of radix curcumae, 25 parts of pseudo-ginseng, 45 parts of.

(1) sun drying equal parts of radix Aconiti Kusnezoffii and rhizoma arisaematis, slicing, pulverizing into 50 mesh powder, mixing with succus Zingiberis recens, standing at 15 deg.C, removing juice, and air drying;

(5) mixing the raw materials of other components in proportion, grinding into fine powder to 505 meshes, adding the fine powder into the solution obtained in the step (4), and uniformly stirring; after the mixture is uniformly stirred, checking the water-free state and the water-dripping-free state, and finishing the primary preparation;

Example 5:

an ointment for treating gouty arthritis is prepared from the following raw materials in parts by weight: 200 parts of vaseline, 12 parts of raw kusnezoff monkshood root, 30 parts of pollen, 15 parts of golden cypress, 10 parts of turmeric, 10 parts of angelica dahurica, 12 parts of mangnolia officinalis, 12 parts of dried orange peel, 12 parts of raw arisaema tuber, 12 parts of rhizoma atractylodis, 12 parts of raw liquorice, 12 parts of radix angelicae pubescentis, 12 parts of schizonepeta, 12 parts of mint, 12 parts of indigo naturalis, 12 parts of edible tulip, 10 parts of rheum officinale, 13 parts of cape jasmine, 13 parts of golden cypress, 13 parts of scutellaria baicalensis, 13 parts of rhizoma paridis, 10 parts of radix puerariae, 10 parts of radix curcumae, 20 parts of pseudo-ginseng, 50 parts of borneol.

(1) sun drying equal parts of radix Aconiti Kusnezoffii and rhizoma arisaematis, slicing, pulverizing into 50 mesh powder, mixing with succus Zingiberis recens, standing at 12 deg.C, removing juice, and air drying;

(4) adding ichthyol and methyl salicylate into the solution obtained in the step (3), keeping the temperature at 72 ℃, and stirring uniformly;

The ointment for treating gouty arthritis is reasonable in formula design, adopts medicinal materials with different components and different medicinal properties to carry out scientific compatibility, has the effects of promoting blood circulation to remove blood stasis, dredging collaterals, relieving swelling and pain, relaxing tendons and activating collaterals, is convenient and safe to use, has low skin sensitivity of a patient, does not influence daily work and life when being pasted on an affected part, and solves the problem of tissue swelling caused by gouty arthritis.

The application method of the ointment for treating gouty arthritis comprises the following steps: the surface of the skin of the affected part is cleaned, the ointment is applied to the affected part, and each application is carried out for 1 day, and 3 applications are taken as a treatment course.

The therapeutic effect judgment standard is as follows:

and (3) curing: the constitution is strengthened and the movement is free; the local red, swelling, heat and pain are obviously relieved; the subcutaneous ecchymosis is obviously reduced.

Improvement: constitution enhancement and slight limitation of movement; local red, swelling, heat and pain are relieved;

and (4) invalidation: constitution enhancement and limited activity; local red, swelling, heat and pain

80 patients are treated and used clinically, wherein 30 patients have acute inflammation, 20 patients have subacute inflammation, 30 patients have chronic inflammation, 75 patients have male inflammation and 5 patients have female inflammation; the effective rate of the traditional Chinese medicine composition reaches over 90% in the minimum 18 years and the maximum 60 years, and the traditional Chinese medicine composition achieves better clinical curative effect no matter acute or non-acute inflammation.

Typical examples are:

1) in case 1, the soft tissues around the first metatarsophalangeal joint are red, swollen and painful due to acute gouty arthritis in the age of 45-year old and male, the ointment for treating gouty arthritis is applied externally and cured for more than two years, and the disease does not relapse after being cured.

2) Case 2, the soft tissues around the right knee joint are red, swollen, painful and tendering due to acute gouty arthritis and general weakness when the disease occurs, the ointment for treating gouty arthritis is applied externally and cured for more than three years, and the disease does not relapse after being cured.

3) Case 3, the soft tissues around the ankle joint of the right foot are red, swollen, painful and fever caused by some king, male and 52-year old acute gouty arthritis, and the whole body is weak when the disease occurs, after the ointment for treating gouty arthritis is externally applied, the disease is cured, the disease has been cured for two or half years, and the disease does not relapse after the disease is cured.

4) Case 3, when a certain patient or woman in the age of 46 years old in Liu and chronic gouty arthritis cause red swelling, pain and fever of soft tissues around the thumb joint of the right foot, the activity is limited, and the whole body is weak when the disease occurs, the patient is cured and moves normally after the ointment for treating gouty arthritis is externally applied, and the disease does not relapse after the patient has been cured for two or half years.

5) Case 3, when someone else, male, 28 years old, the soft tissues around the left knee joint are red and swollen, painful and fever caused by acute gouty arthritis, and the whole body is weak during the disease, the ointment for treating gouty arthritis is obviously relieved after being pasted, and the disease does not relapse within half a year at present.

Because the clinical typical treatment cases are more, the clinical typical treatment cases cannot be listed again.

The above description is an embodiment of the present invention. The present invention is not limited to the above embodiments, and any structural changes made under the teaching of the present invention shall fall within the protection scope of the present invention, which is similar or similar to the technical solutions of the present invention.

Claims

1. An ointment for treating gouty arthritis comprises vaseline and is characterized by also comprising the following components: radix Aconiti Kusnezoffii, pollen, cortex Phellodendri, Curcuma rhizome, radix Angelicae Dahuricae, cortex Magnolia officinalis, pericarpium Citri Tangerinae, rhizoma arisaematis, rhizoma Atractylodis, Glycyrrhrizae radix, radix Angelicae Pubescentis, herba Schizonepetae, herba Menthae, indigo naturalis, Pseudobulbus Cremastrae seu pleiones, radix et rhizoma Rhei, fructus Gardeniae, cortex Phellodendri, Scutellariae radix, rhizoma paridis, radix Puerariae, radix Curcumae, Notoginseng radix, Borneolum Syntheticum, magnesium sulfate, vaseline, ichthammol and rhizoma Zingiberis recens; the feed is prepared from the following raw materials in parts by weight: 210 parts of Vaseline 185-containing material, 10-15 parts of raw kusnezoff monkshood root, 20-35 parts of pollen, 12-20 parts of golden cypress, 7-12 parts of turmeric, 8-13 parts of angelica dahurica, 10-15 parts of mangnolia officinalis, 10-15 parts of dried orange peel, 10-20 parts of raw arisaema tuber, 10-15 parts of rhizoma atractylodis, 10-15 parts of raw licorice, 10-20 parts of radix angelicae pubescentis, 10-15 parts of schizonepeta, 10-18 parts of mint, 10-20 parts of indigo naturalis, 10-18 parts of Indian iphigenia bulb, 8-15 parts of rhubarb, 10-18 parts of gardenia, 10-20 parts of golden cypress, 10-16 parts of scutellaria baicalensis, 10-15 parts of rhizoma paridis, 8-15 parts of radix puerariae, 8-15 parts of radix curcumae, 15-30 parts of pseudo-ginseng, 40-60 parts of borneol, 25-40.

2. The ointment for treating gouty arthritis according to claim 1, which is prepared from the following raw materials in parts by weight: 200 parts of vaseline 185-containing material, 10-12 parts of raw kusnezoff monkshood root, 25-35 parts of pollen, 12-16 parts of golden cypress, 7-10 parts of turmeric, 8-10 parts of angelica dahurica, 10-12 parts of mangnolia officinalis, 10-12 parts of dried orange peel, 10-15 parts of raw arisaema tuber, 10-13 parts of rhizoma atractylodis, 10-13 parts of raw liquorice, 10-15 parts of radix angelicae pubescentis, 10-13 parts of schizonepeta, 10-15 parts of mint, 10-15 parts of indigo naturalis, 10-15 parts of edible tulip, 8-12 parts of rheum officinale, 10-15 parts of cape jasmine, 10-15 parts of golden cypress, 10-15 parts of scutellaria baicalensis, 12-15 parts of paris polyphylla rhizome, 8-11 parts of radix puerariae, 8-12 parts of radix curcumae, 15-25 parts of pseudo-ginseng, 45-55 parts of borneol, 25-.

3. The ointment for treating gouty arthritis according to claim 1, which is prepared from the following raw materials in parts by weight: 200 parts of vaseline, 12 parts of raw kusnezoff monkshood root, 30 parts of pollen, 15 parts of golden cypress, 10 parts of turmeric, 10 parts of angelica dahurica, 12 parts of mangnolia officinalis, 12 parts of dried orange peel, 12 parts of raw arisaema tuber, 12 parts of rhizoma atractylodis, 12 parts of raw liquorice, 12 parts of radix angelicae pubescentis, 12 parts of schizonepeta, 12 parts of mint, 12 parts of indigo naturalis, 12 parts of edible tulip, 10 parts of rheum officinale, 13 parts of cape jasmine, 13 parts of golden cypress, 13 parts of scutellaria baicalensis, 13 parts of rhizoma paridis, 10 parts of radix puerariae, 10 parts of radix curcumae, 20 parts of pseudo-ginseng, 50 parts of borneol.

4. A method of preparing an ointment for the treatment of gouty arthritis according to claim 1, comprising the steps of:

5. The method for preparing the ointment for treating gouty arthritis according to claim 4, wherein the raw kusnezoff monkshood root and the raw arisaema tuber in the step (1) are pulverized into 45-55 meshes and then mixed with the ginger juice according to a ratio of 1: 3.

6. The method for preparing an ointment for the treatment of gouty arthritis according to claim 4, wherein the mixed solution in the step (1) is left for 45 hours.

7. The method for preparing an ointment for the treatment of gouty arthritis according to claim 4, wherein the temperature of the mixed solution is controlled to 80 ℃ during the process of dissolving vaseline in equal amount of boiled water in step (2).