CN102228485A - Composition for burn rehabilitation and preparation method thereof - Google Patents
Composition for burn rehabilitation and preparation method thereof Download PDFInfo
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- CN102228485A CN102228485A CN201110154431XA CN201110154431A CN102228485A CN 102228485 A CN102228485 A CN 102228485A CN 201110154431X A CN201110154431X A CN 201110154431XA CN 201110154431 A CN201110154431 A CN 201110154431A CN 102228485 A CN102228485 A CN 102228485A
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Abstract
The invention provides a composition for burn rehabilitation and a preparation method thereof. The composition comprises pine needle and pharmaceutical excipients. The composition has remarkable effects of treating scars, pigmentation and the like of burned patients, and can remarkably remove scars, pigmentation and the like caused by burns to ensure that the skin of the patients is basically recovered.
Description
Technical field
The present invention relates to a kind of composition and method of making the same that is used for burn rehabilitation.
Background technology
In the burn treating field, the success rate of large-area burns treatment is in the leading level in the world all the time in China.But the burn disability rate is in continuous increase.
It is reported that annual about 1,200,000 burn patients of China need hospitalization.
Burn is often left over different scar hyperplasia of degree and pigmentation after curing, and severe patient causes dysfunction, joint deformity, even permanent disbility.Make the patient not only bear the body misery, simultaneously the psychic trauma that also brought by dysfunction.Therefore, the burn rehabilitation treatment has become a great problem of world's medical profession, developed countries combines early treatment of burn, physical therapy, physical exercise therapy, occupational therapy together at present, become conventional therapy, professional and equipment are arranged, sound system and look previous tretament and the later stage rehabilitation of equal importance, make the body and mind of burn patient all obtain rehabilitation to greatest extent.
China's burn rehabilitation treatment at present obviously lags behind, from China's burn treating development, the factor that rehabilitation is carried out in restriction has: 1, understanding is not enough inwardly, most medical institutions and family numbers of patients are still the sole purpose of help as burn treating of curing the disease, even if think as long as wound healing is cured.2, lack professional and equipment.Though 3 recognize the importance of rehabilitation, are ignorant of rehabilitation technique, therefore, the best opportunity that much needs the patient of rehabilitation to lose rehabilitation.
Therefore, still need at present and want a kind of effective burn rehabilitation medicine, carry out symptomatic treatment, improve patient's quality of life at sequela such as scar hyperplasia after the burn and pigmentations.
Summary of the invention
In order to address the above problem, burn patient is carried out rehabilitation, solve sequela such as scar hyperplasia and pigmentation, the inventor has studied a kind of compositions that is used for burn rehabilitation, wherein comprises Folium Pini and pharmaceutically useful adjuvant.Behind the said composition applying clinical, problems such as the scar hyperplasia of burn patient and pigmentation have been reduced.This has not only alleviated patient's body and mind misery, greatly reduce disability rate, and reduced later stage plastic operation number of times scope, make patient can not only recover to take care of oneself, and most patients reintegrate into society, recover original right, status and dignity, improved patient's quality of life greatly, for social patient in family reduces the heavy burdens.
Folium Pini can be the Folium Pini of Pinus tabuliformis, Pinus sylvestnis var. mongolica Litv., Pinus densiflora, Pinus koraiensis etc.Century-old above Age-old pine trees pin curative effect the best.The above Age-old pine trees of numerous mountains a century are wild plant, and pollution-free, nontoxic is that the occurring in nature vitality is the most vigorous, life-prolonging seeds, and the winter defies severe cold, and the summer is not afraid of heat, is antidotal evergreen tree.Folium Pini is the representative medicinal part of pinaster.Folium Pini is to contain fragrant volatile oil, and the material of bioflavonoids also contains amounts of protein, aminoacid, multivitamin, trace element and chlorophyll and oligomeric proanthocyanidin simultaneously.
The inventor is surprised to find that Folium Pini has unexpected effect for the rehabilitation of burn patient.Generally speaking, Folium Pini and optional pharmaceutically useful adjuvant can play good burn rehabilitation effect.On this basis, in order to realize the rehabilitation of burn patient better, the drug matching of Folium Pini and selection can also be obtained being used for the compositions of burn rehabilitation.
In one embodiment, the invention provides a kind of compositions that is used for burn rehabilitation, wherein comprise Folium Pini and pharmaceutically useful adjuvant.Mainly utilize the effect of Folium Pini, can play the effect that promotes burn rehabilitation.Under the preferable case, the content of Folium Pini accounts for the 50%-90% of described composition total weight, more preferably 70%-90%.Folium Pini is the main component in the present composition, and Folium Pini content can obtain more effectively therapeutic effect in this scope.
In one embodiment, the invention provides the compositions that is used for burn rehabilitation, said composition can be prepared into unguentum, is used for massaging the affected part, reaches required curative effect by skin absorbs.Can select different compatibility Chinese medicine and Folium Pini further to make up at patient's concrete condition, so that the compositions that makes can be treated patient's disease pointedly.When described compositions is used to prepare unguentum, can earlier described Folium Pini and Chinese medicine ingredients be crushed to 100-120 order at least, 120-200 order at least for example, or thinner.
One preferred embodiment in, described unguentum comprises following ingredient: Folium Pini, Olibanum, Myrrha, Radix Notoginseng, Sanguis Draxonis, Radix Ampelopsis, the Radix Angelicae Dahuricae, Cortex Phellodendri, Radix Sophorae Flavescentis, Radix Arnebiae (Radix Lithospermi), Moschus, Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Calamina, Margarita powder, Cortex Dictamni, Radix Salviae Miltiorrhizae and Radix Angelicae Sinensis.This unguentum mainly has the effect of blood activating and promoting tissue regeneration, is mainly used in the burns rear wound healing initial stage, and cardinal symptom is with residual wound, and ulceration infects, is difficult for healing, the patient of vein obstruction of lymphatic return, swelling repeatedly.Wherein: Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Olibanum, Radix Notoginseng and Radix Angelicae Sinensis have the effect of blood circulation promoting and blood stasis dispelling, can alleviate the pain sensation reaction of cicatrix wound surface greatly; The Radix Angelicae Dahuricae, Sanguis Draxonis, Radix Ampelopsis, Radix Arnebiae (Radix Lithospermi), Myrrha, Calamina have promoting tissue regeneration and ulcer healing, detumescence dissipating blood stasis, the effect of heat-clearing and toxic substances removing; Rhizoma Et Radix Notopterygii has antiinflammatory, antiallergic, and antioxidation especially has the obvious suppression effect to various negative bacillus and staphylococcus aureus.Above-mentioned all medicines and Folium Pini share, and by blood circulation promoting and blood stasis dispelling, regulate local blood circulation, promote wound healing and epithelial tissue maturation, thereby have accelerated the rehabilitation of burn patient.
Second preferred embodiment in, described unguentum comprises following ingredient: Folium Pini, Concha Ostreae, Thallus Laminariae (Thallus Eckloniae), Periostracum Cicadae, Galla Chinensis, Spica Prunellae, Bombyx Batryticatus, Carapax Trionycis, Radix Et Rhizoma Rhei, Fructus Atriplicis Sibiricae, Rhizoma Curcumae Longae, big gun Squama Manis (processed).This unguentum mainly has the effect of softening cicatrix, is mainly used in scar hyperplasia behind the burn wound healing, sufferings unbearably, symptom such as xerosis cutis, crowfoot cracks, the patient of cicatrix demand is arranged.Wherein, Concha Ostreae, Thallus Laminariae (Thallus Eckloniae), Sargassum, Carapax Trionycis, Spica Prunellae has drastically removing blood stasis and resolving static blood, hard masses softening and resolving, the effect of dispersing swelling and dissipating binds; Periostracum Cicadae has the effect of diffusing wind heat extraction; Galla Chinensis has acid and holds back astringent therapy, subduing swelling and detoxicating, and vasoconstrictive, the effect of coagulated protein can make fibroblast to antioxidant radical, collagen protein, new vessels is received to compress and is contracted, and breaks off blood flow, and the absorption of cicatrix is calmed down; Radix Et Rhizoma Rhei has removing pathogenic heat from blood and toxic substance from the body, the effect of heat clearing away blood stasis dispelling; Rhizoma Curcumae Longae has the circulation of qi promoting removing blood stasis with potent drugs, the effect of inducing menstruation to relieve menalgia; Squama Manis has the tolerance that improves cicatrix, suppresses mutation, detumescence collateral dredging, antiphlogistic effect; The Fructus Kochiae, Herba Menthae, Radix Saposhnikoviae, Radix Glycyrrhizae has antiinflammatory, antiallergic, clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching, effects such as removing damp and stopping pain.Above-mentioned all medicines and Folium Pini of the present invention share and can improve the cicatrix sufferings effectively, irritated and infection, and the specificity that is suppressed to fibrocyte collagen protein new capillary vessel effectively increases, and blocking blood flow absorbs scar tissue, and softening, maturation is calmed down.
The 3rd preferred embodiment in, described unguentum comprises following ingredient: Folium Pini, Poria, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Semen Persicae, Radix Arnebiae (Radix Lithospermi), Aloe, Sargassum, Herba Menthae.This unguentum has the effect of eliminating spots and moisturizing skin.These medicines share has skin moistening and itch stopping, and skin moistening is analgesic, pore refining, brightening, dispelling spots, dispelling, wrinkle resistantly wait effect, the back pigmentation of burning is improved significantly and repair, be mainly used in pigmentation, depigmentation, xerosis cutis behind the burn wound healing, the patient of skin moistening and whitening demand is arranged.
The above-mentioned various compositionss that are used to prepare unguentum also can be prepared into powder, powder or medicated bag, and when just being prepared into powder, described Folium Pini and Chinese medicine ingredients can be crushed to 80-100 order at least, for example 100-200 order or thinner at least; When being prepared into powder, described Folium Pini and Chinese medicine ingredients can be crushed to 40-60 order at least, for example 60-200 order or thinner at least; When being prepared into medicated bag, described Folium Pini and Chinese medicine ingredients can be crushed to 20-40 order at least, for example 40-200 order or thinner at least.Under the situation that does not influence the drug regimen amount, the fineness of above-mentioned powder, powder or medicated bag also can be thinner, and concrete fineness can be regulated according to concrete performance.For example, when described compositions is used as facial mask powder, it can be crushed to 40-200 order, 200-1000 order even thinner, if working condition allows, even can be crushed to nanoscale, to strengthen the availability of its medicine.
For the patient of state of an illness more complicated, also can aforementioned pharmaceutical compositions be used in combination, or use stage by stage, to reach optimum therapeuticing effect according to its concrete condition.
In addition, in yet another embodiment of the present invention, provide the compositions that is used for burn rehabilitation, said composition can be prepared into powder, this powder is coated on the affected part after, by to the affected part package, reach the pigment of dispelling, the effect of softening cicatrix.Described powder can comprise: Folium Pini, Sargassum, Poria, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Bombyx Batryticatus, Radix Et Rhizoma Rhei, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, the Fructus Kochiae, Semen Persicae, Radix Arnebiae (Radix Lithospermi), Aloe, Radix Angelicae Sinensis and Margarita powder.One preferred embodiment in, described powder comprises: by weight, account for 75% Folium Pini; Account for 10% Sargassum; Account for 15% Poria, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Bombyx Batryticatus, Radix Et Rhizoma Rhei, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, the Fructus Kochiae, Semen Persicae, Radix Arnebiae (Radix Lithospermi), Aloe, Radix Angelicae Sinensis and Margarita powder altogether.This powder has that blood circulation promoting and blood stasis dispelling, skin moistening and itch stopping, skin moistening pain relieving, skin moistening are analgesic, skin moistening granulation promoting, whitening and speckle dispelling, wrinkle resistant effect, and the back pigmentation improves significantly and repair to burning.Compositions of the present invention is when being prepared into powder, and described Folium Pini and Chinese medicine ingredients can be crushed to 80-100 order at least.
In another embodiment of the present invention, compositions of the present invention can also provide with the form of powder, by Chinese medicine hot spring dipping bath, plays the promotion wound healing, the remollescent effect of cicatrix.One preferred embodiment in, described powder can comprise: Folium Pini, Poria, Herba Menthae, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, the Fructus Kochiae, Radix Arnebiae (Radix Lithospermi), Cortex Dictamni, Cortex Phellodendri, Rhizoma Et Radix Notopterygii and Radix Et Rhizoma Rhei.Compositions of the present invention is when being prepared into powder, and described Folium Pini and Chinese medicine ingredients can be crushed to 40-60 order at least.
In another embodiment of the present invention, compositions of the present invention can also be prepared into medicated bag, is used for acting on skin by the ionspray device, increases the effect of speckle dispelling, softening cicatrix.Its composition can be identical with the composition of powder embodiment.Compositions of the present invention is when being prepared into medicated bag, and described Folium Pini and Chinese medicine ingredients can be crushed to 20-40 order at least.
Description of drawings
Fig. 1 is patient treatment front and back skin contrast photo: the A that adopts the combination treatment of embodiments of the present invention preparation in the model case 1: before the rehabilitation; B: after the rehabilitation;
Fig. 2 is patient treatment front and back skin contrast photo: the A that adopts the combination treatment of embodiments of the present invention preparation in the model case 2: before the rehabilitation; B: after the rehabilitation;
Fig. 3 is patient treatment front and back skin contrast photo: the A that adopts the combination treatment of embodiments of the present invention preparation in the model case 3: before the rehabilitation; B: in the rehabilitation; C: after the rehabilitation;
Fig. 4 is patient treatment front and back skin contrast photo: the A that adopts the combination treatment of embodiments of the present invention preparation in the model case 4: before the rehabilitation; B: in the rehabilitation; C: after the rehabilitation;
Fig. 5 is patient treatment front and back skin contrast photo: the A that adopts the combination treatment of embodiments of the present invention preparation in the model case 5: before the rehabilitation; B: in the rehabilitation; C: after the rehabilitation;
Fig. 6 is patient treatment front and back skin contrast photo: the A that adopts the combination treatment of embodiments of the present invention preparation in the model case 6: before the rehabilitation; B: after the rehabilitation.
Fig. 7 is patient treatment front and back skin contrast photo: the A of the combination treatment of model case 7 employing embodiments of the present invention preparations: before the rehabilitation; B: in the rehabilitation; C: after the rehabilitation.
The specific embodiment
Describe the specific embodiment of the present invention below in detail, and specify each composition effect of compositions of the present invention in conjunction with specific embodiments:
Compositions of the present invention relates to altogether as following medicine:
Folium Pini, Cortex Phellodendri, Poria, Radix Et Rhizoma Rhei, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Radix Saposhnikoviae, Fructus Atriplicis Sibiricae, Olibanum, Myrrha, Radix Scutellariae, Rhizoma Coptidis, Radix Notoginseng, the Radix Angelicae Dahuricae, Radix Ampelopsis, the Fructus Kochiae, Radix Sophorae Flavescentis, Cortex Dictamni, Carapax Trionycis, Semen Persicae, Radix Arnebiae (Radix Lithospermi), Aloe, Sargassum, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei, Rhizoma Et Radix Notopterygii, Thallus Laminariae (Thallus Eckloniae), Concha Ostreae, Periostracum Cicadae, Spica Prunellae, Bombyx Batryticatus, Radix Scrophulariae, Radix Angelicae Sinensis, Margarita powder, Sanguis Draxonis, Calamina, Galla Chinensis, Radix Salviae Miltiorrhizae, Moschus, Squama Manis.
The effect of each medicine is described as follows:
Folium Pini: extract from pine needles is rich in saccharide, crude protein, crude fat, several amino acids and multiple micro-ore deposit element, multivitamin, bioflavonoid material, quintessence oil, chlorophyll, unsaturated fatty acid, enzyme and coenzyme isoreactivity material.The medicinal representation position of pinaster is a Folium Pini, and the medicinal ingredient of Folium Pini is higher than other positions of pinaster, not only contains large number of biological Flavonoid substances, oligomeric proanthocyanidin, also is rich in chlorophyll, multivitamin.Extract from pine needles can be used for the expansion artery blood vessel, increases the erythrocyte oxygen carrying capacity, and blood circulation promoting improves the function of blood capillary, improves immunity, increases hormonal secretion, and is strong smart, makes the rejuvenation of organizing of health.Simultaneously, also have logical all keys, the stagnated fire of loosing, the effect of reducing swelling and alleviating pain.
Cortex Phellodendri: heat clearing and damp drying, pathogenic fire purging are removed and are steamed, and skin ulcer is treated in detoxifcation.
Poria: dispelling speckles and whitening face, moist skin, all right raise immunity, blood vessel dilating.Poria is flat, slightly sweet flavor, strengthening the spleen, calm the nerves, promoting diuresis to eliminate damp pathogen.
Radix Et Rhizoma Rhei: relieve internal heat anticancer, purge heat and lead long-pending, detumescence by becoming silted up, attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Detoxifcation.
The Pseudobulbus Bletillae (Rhizoma Bletillae): astringing to arrest bleeding, detumescence and promoting granulation.The Pseudobulbus Bletillae (Rhizoma Bletillae) is a orchid family, the underground ground stem of the herbaceos perennial Pseudobulbus Bletillae (Rhizoma Bletillae).Contain compositions such as starch, glucose, volatile oil, phlegmatic temperament, bitter in the mouth, sweet, flat and the puckery and stick-slip of property.External Castor Oil skin removes skin ulcer on the face." property of medicine opinion " record: " control skin ulcer on the face, make us flesh and slide." the Compendium of Material Medica record: " black, the speckle dispelling of washing one's face." it mainly is skin moistening flour, goes scar, and can cure rhagadia manus et pedis etc., be the medicine commonly used of beauty treatment in ancient times.
Herba Menthae: have the wind heat of dispersing, the rash detoxifcation, antipruritic.Sweating and heat resolving makes skin capillary vascular expansion, promotes sweat gland secretion, increases heat radiation, suppresses pain nerve, pain relieving.Suppress the blood vessel-specific expansion; Antibiotic, antiviral.
Radix Saposhnikoviae: expelling pathogenic wind from the body surface, removing damp and stopping pain, the effect of killing parasites for relieving itching.Antiinflammatory, antiallergic.
Fructus Atriplicis Sibiricae: conjunctival congestion and swelling pain, diseases such as skin pruritus.
Olibanum: invigorate blood circulation circulation of qi promoting, pain relieving.
Myrrha: the blood and dissolving stasis that looses, promoting blood circulation and hemostasis, detumescence and promoting granulation.
Radix Scutellariae: heat clearing and damp drying, eliminating fire and detoxication.
Rhizoma Coptidis: pathogenic fire purging, dampness, detoxifcation, parasite killing.
Radix Notoginseng: hemostasis, dissipating blood stasis, detumescence, pain relieving.
The Radix Angelicae Dahuricae: wind-damp dispelling, the evacuation of pus of invigorating blood circulation, granulation promoting pain relieving.Ulcer sores, skin pruritus.Antipyretic-antalgic, antiinflammatory.Whiten, skin is moist smooth.
Radix Ampelopsis: heat-clearing and toxic substances removing; Removing obstruction for relieving pain; Promoting tissue regeneration and ulcer healing.
Calamina: be widely used in department of dermatologry, anticorrosion, convergence, protective agent treatment scytitis or surface injury as moderate suppress local aureus growth.Can partially absorb the wound surface juice, convergence, protective effect are arranged.
The Fructus Kochiae: clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.Rubella, eczema, skin pruritus.Antibiotic, antiallergic.
Radix Salviae Miltiorrhizae: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind.
Radix Sophorae Flavescentis: heat clearing and damp drying, eczema, eczema, skin pruritus etc.
Cortex Dictamni: heat clearing and damp drying, the detoxifcation of dispeling the wind.Be used for damp and hot sore, yellow fluid is dripping, eczema, rubella, scabies skin ulcer leprosy, rheumatism pyretic arthralgia.
Carapax Trionycis: hard masses softening and resolving, bring down a fever to remove and steam.The hypertrophy that can suppress connective tissue so the energy dispersing swelling and dissipating binds has the effect that increases plasma protein, can promote erythrocyte new life; Can improve immunity.
Semen Persicae: moistening skin beautifying, blood circulation promoting and blood stasis dispelling, blood stasis removing and clots absorbing: antiinflammatory, antiallergic, analgesia, the softening the hard mass removing food stagnancy is alleviated dim coarse.
Radix Arnebiae (Radix Lithospermi): removing heat from blood, invigorate blood circulation purple black, the skin infection of detoxifcation rash, macule, eczema, burn due to hot liquid or fire.Clearing away heat and cooling blood, calentura skin eruption, eczema, dysentery, burn.
Aloe: speckle dispelling, anti-acne, skin whitening, strengthen skin brightness, skin keeps moistening and elasticity.Endocrine regulation, in and melanin, improve the synthetic function of collagen protein.
Sargassum: softening the hard mass, diuretic, detumescent.Main scrofula, goiter is gathered, edema.Whiten moisturizing, antiinflammatory.
Rhizoma Chuanxiong: blood-activating and qi-promoting, wind-expelling pain-stopping.
Radix Et Rhizoma Rhei: removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation, eliminating fire and detoxication is used for pathogenic fire,toxin and furuncles.
Rhizoma Et Radix Notopterygii: cold expelling, dispel the wind dehumidifying, pain relieving.Analgesic, analgesia, antiinflammatory, antiallergic, antioxidation, antibiotic, various negative bacillus and staphylococcus aureus there are the obvious suppression effect.
Thallus Laminariae (Thallus Eckloniae): hard masses softening and resolving, diuretic.Be used for goiter, scrofula, edema.
Concha Ostreae: hard masses softening and resolving has convergence, calmness, detoxifcation, analgesic effect.
Periostracum Cicadae: the wind heat extraction that looses, measles without adequate eruption, rubella pruritus, conjunctival congestion cataracta.
Spica Prunellae: relieve inflammation or internal heat eliminating stagnation, detumescence, scrofula.
Bombyx Batryticatus: dispelling wind-evil and transforming calculus, pain relieving, antipruritic.Negative bacillus and staphylococcus aureus there is inhibitory action.
Radix Scrophulariae: clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing.Antiinflammatory, antibiotic.
Radix Angelicae Sinensis: regulate body's immunity, cosmetology effect, the effect of invigorating blood circulation of enriching blood, antibacterial, arteriosclerosis effect.
Margarita powder: detoxifcation life, skin infection is not held back.Whiten, control oil, anti-acne, pore cleanser, light speckle, granulation promoting.Improve the colour of skin, effectively remove on the face glossy, heat-clearing and toxic substances removing, cleaning skin, the control oil content also can promote damaged tissues regeneration to recover.A large amount of trace element contained in the Margarita powder can effectively be checked the increase of lipid peroxidation, thereby effectively remove three big speckles.
Sanguis Draxonis: the external hemostasia and promoting granulation is held back skin ulcer, promoting blood circulation to remove blood stasis pain relieving for oral administration.Be used for traumatic injury, congestion swells and ache, traumatic hemorrhage, ulcer being unable to heal.
Radix Glycyrrhizae: heat-clearing and toxic substances removing, pain relieving, coordinating the actions of various ingredients in a prescription, carbuncle sore tumefacting virus, cushion toxicity, antiinflammatory, antiallergic.
Moschus: good blood circulation promoting and dispersing pathogen accumulation is arranged, the reducing swelling and alleviating pain effect.
Squama Manis: blood circulation promoting and dispersing pathogen accumulation, eliminating carbuncle is burst hard, lump in the abdomen; Rheumatic arthralgia, carbuncle, scrofula.
Galla Chinensis: traumatic hemorrhage, too fat to move sore, Skin wet and rotten.Gallotannic acid has precipitation to protein, and skin ulcer face mucosa contacts the back histone and is solidified with tannic acid, make the mucosa drying.Form protecting film and play astriction.Antibiotic in addition in addition, antiviral, antitumor is suppressed to fibrocyte, effects such as detoxifcation.
Principal agent wherein is a Folium Pini.Under the situation that guarantees Folium Pini drug effect and content, those skilled in the art can be at dissimilar patients' different demands, and the suitable Chinese medicine of selection and Folium Pini compatibility and its be content separately.Preferred above-mentioned Chinese medicine, more preferably the content of Folium Pini in pharmaceutical composition is about 50-90wt%, more preferably 70-90wt%.The content of all the other Chinese medicines can be about 10-50wt%, or 10-30%.Also can add suitable adjuvant, select suitable content in above-mentioned scope, the content summation that makes Folium Pini, all the other Chinese medicines, adjuvant is 100wt%.
Compositions of the present invention can the preparation cost field in various dosage forms commonly used, be preferably as follows dosage form: unguentum, powder, powder, medicated bag.
(the massage affected part by skin absorbs, reaches required curative effect for embodiment one, unguentum.)
Embodiment (one)-blood activating and promoting tissue regeneration massage cream
Raw material is selected for use: Folium Pini, Olibanum, Myrrha, Radix Notoginseng, Sanguis Draxonis, Radix Ampelopsis, the Radix Angelicae Dahuricae, Cortex Phellodendri, Radix Sophorae Flavescentis, Radix Arnebiae (Radix Lithospermi), Moschus, Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Calamina, Margarita powder, Cortex Dictamni, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis.
The wherein effect of Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Olibanum, Radix Notoginseng, Radix Angelicae Sinensis: blood circulation promoting and blood stasis dispelling, the pain sensation reaction that can alleviate the cicatrix wound surface greatly.
The Radix Angelicae Dahuricae, Sanguis Draxonis, Radix Ampelopsis, Radix Arnebiae (Radix Lithospermi), Myrrha, Calamina: life is held back skin ulcer, detumescence dissipating blood stasis, heat-clearing and toxic substances removing.
Rhizoma Et Radix Notopterygii: antiinflammatory, antiallergic, antioxidation especially has the obvious suppression effect to various negative bacillus and staphylococcus aureus.
All medicines share by blood circulation promoting and blood stasis dispelling, regulate local blood circulation, promote wound healing and epithelial tissue maturation.
Embodiment (two)-softening cicatrix massage cream
Folium Pini, Concha Ostreae, Thallus Laminariae (Thallus Eckloniae), Periostracum Cicadae, Galla Chinensis, Spica Prunellae, Bombyx Batryticatus, Carapax Trionycis, Radix Et Rhizoma Rhei, Fructus Atriplicis Sibiricae, Rhizoma Curcumae Longae, big gun Squama Manis (processed).
Concha Ostreae, Thallus Laminariae (Thallus Eckloniae), Sargassum, Carapax Trionycis, Spica Prunellae: drastically removing blood stasis and resolving static blood, hard masses softening and resolving, dispersing swelling and dissipating binds.
Periostracum Cicadae: the wind heat extraction looses.
Galla Chinensis: astringent therapy is held back in acid, subduing swelling and detoxicating, and vasoconstrictive, coagulated protein can make fibroblast, collagen protein, new vessels receive to compress and contract antioxidant radical, breaks off blood flow, cicatrix is absorbed calm down.
Radix Et Rhizoma Rhei: removing pathogenic heat from blood and toxic substance from the body, heat clearing away blood stasis dispelling.
Rhizoma Curcumae Longae: circulation of qi promoting removing blood stasis with potent drugs, inducing menstruation to relieve menalgia.
Squama Manis: improve the tolerance of cicatrix, suppress mutation, detumescence collateral dredging, antiinflammatory.
The Fructus Kochiae, Herba Menthae, Radix Saposhnikoviae, Radix Glycyrrhizae: have antiinflammatory, antiallergic, clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching, effects such as removing damp and stopping pain.
All medicines share and can improve the cicatrix sufferings effectively, irritated and infection, and the specificity that is suppressed to fibrocyte collagen protein new capillary vessel effectively increases, and blocking blood flow absorbs scar tissue, and softening, maturation is calmed down.
Embodiment (three)-eliminating spots and moisturizing skin massage cream
Folium Pini, Poria, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Semen Persicae, Radix Arnebiae (Radix Lithospermi), Aloe, Sargassum, Herba Menthae.
Above-mentioned all medicines share has skin moistening and itch stopping, and skin moistening is analgesic, pore refining, and brightening, dispelling spots, dispelling, effect such as wrinkle resistant grade, the back pigmentation improves significantly and repair to burning.
Embodiment two. compound pine needle looses and (by to the affected part package, reaches the pigment of dispelling, the effect of softening cicatrix.)
Raw material: by weight, Folium Pini accounts for 75%; Sargassum accounts for 10%; Poria, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Bombyx Batryticatus, Radix Et Rhizoma Rhei, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, the Fructus Kochiae, Semen Persicae, Radix Arnebiae (Radix Lithospermi), Aloe, Radix Angelicae Sinensis, Margarita powder account for 15% altogether.
This powder has blood circulation promoting and blood stasis dispelling, skin moistening and itch stopping, and skin moistening unstings, and skin moistening is analgesic, skin moistening life, whitening and speckle dispelling, wrinkle resistant, the back pigmentation improves significantly and repair to burning.
Embodiment three. the compound pine needle powder (by Chinese medicine hot spring dipping bath, promotes wound healing, the remollescent effect of cicatrix.)
Raw material: Folium Pini, Poria, Herba Menthae, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, the Fructus Kochiae, Radix Arnebiae (Radix Lithospermi), Cortex Dictamni, Cortex Phellodendri, Rhizoma Et Radix Notopterygii, Radix Et Rhizoma Rhei.
Embodiment four, medicated bag
Raw material (acts on skin by the tcm herbal ion aerosol apparatus, increases speckle dispelling, the effect of softening cicatrix with the compound pine needle powder.)
Effect below by clinical case detailed description compositions of the present invention.
48 routine major burn patients different times rehabilitations are observed
1, data and method
1.1 clinical data
Rehabilitation patient's 48 examples after in March, 2006 to 2010, accepted severe burn year March for medical treatment.Wherein male 28 examples, women 20 examples.Maximum 56 years old, minimum 2 years old, the burn gross area was between 40%-99%, dark II degree-III degree burn surface area is between 38%-95%, accept the rehabilitation asynchronism(-nization) after hindering according to patient, be divided into the early rehabilitative intervention group, mid-term rehabilitation group, late period rehabilitation group.Treatment be respectively the course of treatment 8-12 month, more than 1 year, 1-3.Three groups of clinical datas see Table 1
Table 1,48 routine major burn patients clinical data tables 1
1.2 treatment procedure
The patient data storehouse is set up in the assessment 1.2.1 be admitted to hospital, by have a medical check-up, the inquiry of video recording, image, record patient's physical and mental statuse and the handicapped degree of scar hyperplasia.
1.2.2 formulate rehabilitation goal, rehabilitation programme according to patient's scar hyperplasia dysfunction and rehabilitation hope.
1.2.3 mid-stage assessment, evaluation in per 3 months is once evaluated interim rehabilitation, revises and improves therapeutic scheme, drafts new treatment plan again.
1.2.4 end assessment eventually, rehabilitation is evaluated before leaving hospital by the video recording of having a medical check-up, image recording patient scar hyperplasia after finishing comprehensively, and the functional rehabilitation situation compares with the data of being admitted to hospital.And carry out before institute and instruct.
1.2.5 set up patient family contact card, tracking is followed up a case by regular visits to, and holds regularly patient's friendship ties exchanging meeting.
1.3 Therapeutic Method
1.3.1 hot spring Chinese medicine dipping bath
Adopt special-purpose full-automatic remote-controlled microwave surfing dipping bath cylinder, thermal water adds the compound pine needle powder, once a day.Hinder back 3 months with interior (early rehabilitative intervention group), water temperature should be at 34 ℃-35 ℃, hinder afterwards more than 4 months (middle and advanced stage rehabilitation group), and water temperature should be at 36 ℃-38 ℃.
1.3.2 the tcm herbal ion spraying cooperates the massage of maneuver cicatrix
Adopt the blood activating and promoting tissue regeneration massage cream of inventor's development, soften cicatrix massage cream, eliminating spots and moisturizing skin massage cream according to patient's different parts, different times scar hyperplasia situation, by by, maneuver such as rub, press, lead, draw, pull, suppress scar hyperplasia, control joint accretion and deformity, once a day.
1.3.3 Chinese medicine package
Adopt the compound pine needle of inventor's development to loose,, be applied to the cicatrix position equably with thermal water furnishing pasty state, package 40 minutes, once a day.
1.3.4 Elastic bandage pressurization
According to different parts, the elastic force pressure cuffs is made in processing, and 24 hours persistent pressures were adhered to more than 1 year.
1.3.5 plastic clamping plate are fixed
Plastic clamping plate are cut into the desired area shape, put into about 70 degree hot water, mould immediately, are fixed in contracture position antagonism contracture.
1.3.6 wax therapy physical therapy
This method is used for that cicatrix is aging, quality is hard and joint part, once a day or the next day once.
1.3.7 active functions training
After passive rehabilitation treated for 1 week, increase patient's active functions training program.
By daily life training, the style entertainment training, the training of occupational function such as apparatus makes patient reach the rehabilitation purpose in amusement and tasting functional exercise.
1.3.8 psychological rehabilitation
The inpatient is carried out psychological assessment, analyze the patient's of disabling after burning mental change characteristics and rule, Applied Psychology theory, knowledge technology carry out psychology and behavior intervention, formulate the psychological rehabilitation plan, pass through the psychotherapy, alleviate to eliminate and correct the psychosocial factor that influences patient, embodying with patient is the rehabilitation pattern at center.
2, efficacy assessment standard
Functional part is with reference to ADL (Activity of daily Living)
[1]Grade scale joint motion recovery extent and have or not scar hyperplasia as the efficacy evaluation foundation.
The basic healing: the cicatrix deliquescing flattens, and skin recovers elasticity, and slight piebaldism vestige is arranged, and function of joint is recovered normal ADL4 level fully.
Produce effects: scar thickness≤2mm, most of cicatrix deliquescing flattens, and skin has depigmentation and pigmentation, and it is normal that joint component is recovered, and local joint is slightly limited, the ADL3-4 level.
Effectively: scar thickness 〉=2mm, the deliquescing of part cicatrix flattens, and range of motion increases more than 20 degree ADL1-2 level than treatment is preceding.
Invalid: no change ADL is 0 grade before and after the treatment.
3, result: see Table 2
Combined rehabilitation treatment observation of curative effect table 2
4, discuss:
From table 2 result as seen, early stage combined rehabilitation treatment can not only reduce the burn disability rate, reduces operability, reduces the financial burden, and patient's physical and psychological rehabilitation has been played important positive role.
The therapeutic effect of the present composition hereinafter is described with several model cases more intuitively:
Model case 1.
Patient's basic condition: sex: woman's age: 32.Pigmentation after the neck surface second degree burn, slight hypertrophy.
Treatment means: use the eliminating spots and moisturizing skin massage cream of embodiment (three), the compound pine needle of embodiment two package that looses, the medicated bag ionspray Comprehensive Treatment of embodiment four.Treatment cross-reference figure is referring to Fig. 1.
Model case 2
Patient's basic condition: sex: woman's age: 50
The neck surface deep burn, scar hyperplasia, appearance is badly damaged.
Treatment: the blood activating and promoting tissue regeneration massage cream of embodiment () is used in combination with the softening cicatrix massage cream of embodiment (two), the compound pine needle of embodiment two package that looses, the medicated bag ionspray Comprehensive Treatment of embodiment four.Treatment cross-reference figure is referring to Fig. 2.
Model case 3
Patient's basic condition: sex: woman's age: 33
Treatment means is with model case 2.Treatment cross-reference figure is referring to Fig. 3.
Model case 4
Patient's basic condition: sex: man's age: 41
Treatment means is with model case 2.Treatment cross-reference figure is referring to Fig. 4.
Model case 5
Patient's basic condition: sex: woman's age: 23
Treatment means is with model case 2.Treatment cross-reference figure is referring to Fig. 5.
Model case 6
Patient's basic condition: sex: man's age: 3, large tracts of land severe burn treatment case.
Treatment means: use the powder hot spring dipping bath of embodiment three, embodiment () and (twos') massage cream is massaged, the medicated bag ionspray of embodiment four, the compound pine needle of embodiment two package that looses.Treatment cross-reference figure is referring to Fig. 6.
Model case 7
Patient's basic condition: sex: the woman, the age: 19, hot magnesium powder third degree burn.
Treatment means: with model case 6.Treatment cross-reference figure is referring to Fig. 7.
Accept case 268 examples of rehabilitation product treatment over 4 years, effective percentage 100%.Burn surface area 90% above case 26 examples.Above 32 examples of 50%-89%, 49% following case 210 examples, 90% above patient needs other people assist except that an example, and wherein 20 examples are all taken care of oneself, and 4 examples can be taken part in the work.All the other 242 routine full recovery functions, appearance obtains good recovery, all returns social work and goes to school.
Those skilled in the art all are appreciated that; the above only is preferred embodiment of the present invention, and is in order to restriction the present invention, within the spirit and principles in the present invention not all; any modification of being made, be equal to replacement, improvement etc., all should be included within the scope of protection of the invention.
Claims (10)
1. a compositions that is used for burn rehabilitation comprises Folium Pini and optional pharmaceutically useful adjuvant.
2. the compositions that is used for burn rehabilitation as claimed in claim 1, the content of wherein said Folium Pini accounts for the 50%-90% of described composition total weight, preferred 70%-90%.
3. the compositions that is used for burn rehabilitation as claimed in claim 1 or 2 wherein further comprises Olibanum, Myrrha, Radix Notoginseng, Sanguis Draxonis, Radix Ampelopsis, the Radix Angelicae Dahuricae, Cortex Phellodendri, Radix Sophorae Flavescentis, Radix Arnebiae (Radix Lithospermi), Moschus, Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Calamina, Margarita powder, Cortex Dictamni, Radix Salviae Miltiorrhizae and Radix Angelicae Sinensis.
4. the compositions that is used for burn rehabilitation as claimed in claim 3 wherein further comprises Concha Ostreae, Thallus Laminariae (Thallus Eckloniae), Periostracum Cicadae, Galla Chinensis, Spica Prunellae, Bombyx Batryticatus, Carapax Trionycis, Radix Et Rhizoma Rhei, Fructus Atriplicis Sibiricae, Rhizoma Curcumae Longae and big gun Squama Manis (processed).
5. the compositions that is used for burn rehabilitation as claimed in claim 1 or 2 wherein further comprises Poria, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Semen Persicae, Radix Arnebiae (Radix Lithospermi), Aloe, Sargassum and Herba Menthae.
6. the compositions that is used for burn rehabilitation as claimed in claim 1 or 2, wherein Folium Pini content is 75% by weight, and further comprises: the Sargassum that accounts for medicine total amount 10%; Account for 15% Poria, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Bombyx Batryticatus, Radix Et Rhizoma Rhei, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, the Fructus Kochiae, Semen Persicae, Radix Arnebiae (Radix Lithospermi), Aloe, Radix Angelicae Sinensis and Margarita powder altogether.
7. the compositions that is used for burn rehabilitation as claimed in claim 1 or 2 wherein further comprises Poria, Herba Menthae, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, the Fructus Kochiae, Radix Arnebiae (Radix Lithospermi), Cortex Dictamni, Cortex Phellodendri, Rhizoma Et Radix Notopterygii and Radix Et Rhizoma Rhei.
8. compositions that is used for burn rehabilitation comprise as compositions as described in each among the claim 1-7, and its dosage form is powder, powder, medicated bag or unguentum.
9. as preparation of compositions method as described in each among the claim 1-7, comprise that the various constituents with described compositions are crushed to 20-120 order at least, the various constituents after will pulverizing then mix.
10. preparation method as claimed in claim 9 when wherein said compositions is used to prepare powder, is crushed to 80-100 order at least; When described compositions is used to prepare unguentum, be crushed to 100-120 order at least; When described compositions is used to prepare powder, be crushed to 40-60 order at least; When described compositions is used to prepare medicated bag, be crushed to 20-40 order at least.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102526494A (en) * | 2012-03-23 | 2012-07-04 | 徐玉文 | Ointment for treating burning |
| CN103211931A (en) * | 2013-02-22 | 2013-07-24 | 刘爱华 | Pressure-ulcer medicine and preparation method thereof |
| CN103316135A (en) * | 2013-05-28 | 2013-09-25 | 宋金路 | Traditional Chinese medicine preparation for treating scar formed by restoring skin wound and preparation method thereof |
| CN103393813A (en) * | 2013-07-31 | 2013-11-20 | 成都泓泰生物制品有限公司 | Pure Chinese herbal medicine preparation for treating burns and scalds as well as pyogenic infections and open traumas |
| CN103505490A (en) * | 2012-06-20 | 2014-01-15 | 比亚迪股份有限公司 | Wound cleaning liquid |
| CN103920003A (en) * | 2014-04-16 | 2014-07-16 | 青岛市市立医院 | Burn tincture |
| CN109200159A (en) * | 2018-10-30 | 2019-01-15 | 王心海 | A kind of ointment for burns and scalds and preparation method thereof |
| CN109876012A (en) * | 2019-03-21 | 2019-06-14 | 北京隆祺生物科技有限公司 | A kind of Pharmaceutical composition and its application in promotion skin wound healing |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526494A (en) * | 2012-03-23 | 2012-07-04 | 徐玉文 | Ointment for treating burning |
| CN102526494B (en) * | 2012-03-23 | 2013-06-12 | 徐玉文 | Ointment for treating burning |
| CN103505490A (en) * | 2012-06-20 | 2014-01-15 | 比亚迪股份有限公司 | Wound cleaning liquid |
| CN103505490B (en) * | 2012-06-20 | 2016-04-27 | 比亚迪股份有限公司 | A kind of cleaning wound liquid |
| CN103211931A (en) * | 2013-02-22 | 2013-07-24 | 刘爱华 | Pressure-ulcer medicine and preparation method thereof |
| CN103211931B (en) * | 2013-02-22 | 2015-03-04 | 刘爱华 | Pressure-ulcer medicine and preparation method thereof |
| CN103316135A (en) * | 2013-05-28 | 2013-09-25 | 宋金路 | Traditional Chinese medicine preparation for treating scar formed by restoring skin wound and preparation method thereof |
| CN103393813A (en) * | 2013-07-31 | 2013-11-20 | 成都泓泰生物制品有限公司 | Pure Chinese herbal medicine preparation for treating burns and scalds as well as pyogenic infections and open traumas |
| CN103920003A (en) * | 2014-04-16 | 2014-07-16 | 青岛市市立医院 | Burn tincture |
| CN109200159A (en) * | 2018-10-30 | 2019-01-15 | 王心海 | A kind of ointment for burns and scalds and preparation method thereof |
| CN109876012A (en) * | 2019-03-21 | 2019-06-14 | 北京隆祺生物科技有限公司 | A kind of Pharmaceutical composition and its application in promotion skin wound healing |
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