CN103505490A - Wound cleaning liquid - Google Patents
Wound cleaning liquid Download PDFInfo
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- CN103505490A CN103505490A CN201210203351.3A CN201210203351A CN103505490A CN 103505490 A CN103505490 A CN 103505490A CN 201210203351 A CN201210203351 A CN 201210203351A CN 103505490 A CN103505490 A CN 103505490A
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- active component
- cleaning wound
- extract
- wound liquid
- wound
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Abstract
The invention provides a wound cleaning liquid, which comprises an active component, an osmotic pressure regulator and deionized water; the active component is one or more from a wormwood extract, an aloe extract and a mint extract. The wound cleaning liquid provided by the invention has no stimulation to a wound, can clean the wound, also has bactericidal, anti-inflammatory, analgesic, and wound healing promoting effects, and scars are not easy to leave.
Description
Technical field
The present invention relates to a kind of cleaning wound liquid.
Background technology
In prior art, for the medicine cleaning a wound, be mainly: hydrogen peroxide, iodine liquid, ethanol, normal saline, gentamycin washing liquid etc.Although hydrogen peroxide, iodine liquid, ethanol have the effect of sterilizing, but can feel pain very when cleaning a wound, this be because: the oxonium ion in hydrogen peroxide has strong Oxidation, the direct stimulation of oxonium ion and oxygen are a large amount of to be formed and disperse in tissue, wound tension force is increased, and pain increases the weight of; Ethanol, iodine tincture have very strong zest, especially for skin, have damaged wound.And dirty on can only cleaning a wound of normal saline do not have the function of sterilization; Gentamycin is antibiotic type washing liquid, often uses, and easily produces drug resistance.
Summary of the invention
The object of the invention is at least solve one of technical problem existing in prior art.
For this reason, the invention provides a kind of cleaning wound liquid, it comprises active component, osmotic pressure regulator and deionized water; Described active component is one or more in Folium Artemisiae Argyi extract, Aloe extract, Folium Menthae extract.
Simultaneously, the present invention also provides a kind of preparation method of above-mentioned cleaning wound liquid, first active component, osmotic pressure regulator is proportionally mixed, and is dissolved to mix homogeneously with deionized water, then add pH adjusting agent to regulate pH value to 6.5-7.5, encapsulation finally carries out disinfection.
Cleaning wound liquid of the present invention adopts natural Chinese herbal medicine formula, non-stimulated to wound, can clean a wound, and has again the effect of sterilization, antiinflammatory, analgesia, promotion wound healing; Be difficult for scar.
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The specific embodiment
In order to make technical problem solved by the invention, technical scheme and beneficial effect clearer, below in conjunction with embodiment, the present invention is further elaborated.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not intended to limit the present invention.
A liquid, comprises active component, osmotic pressure regulator and deionized water; Described active component is one or more in Folium Artemisiae Argyi extract, Aloe extract, Folium Menthae extract.
Folium Artemisiae Argyi extract contains multiple sesquiterpenoids derivant, as Folium Artemisiae Argyi element, artemetine, cupreol and 5,7-dihydroxy-6, and 3', 4' ,-trimethoxy flavone etc., it has hemostasis, antiallergic, antibiotic effect.
In Aloe extract, contain number of chemical composition, have sterilization, antiinflammatory, antidotal effect, is conducive to wound and recovers, and reduces the formation of cicatrix.
In Folium Menthae extract, contain Herba Menthae quintessence oil, have peat-reek, the distinctive pungent sense of Herba Menthae and cool feeling can stimulate peripheral nerve, cause to reflexive that blood capillary shrinks, thereby reach antiinflammatory, alleviate wound pain, antipruritic effect.
The extracting method of Folium Artemisiae Argyi extract and Folium Menthae extract generally has: organic solvent extraction method: take the effective ingredient of Organic substance in solvent extraction Folium Artemisiae Argyi and Herba Menthae.Water extract method: take aqueous solution as solvent, effective component extracting at certain pressure, time, temperature.Supercritical extraction: the method that replaces conventional solvent to extract target components with supercritical fluid, existing research mostly is CO
2extraction.In some researchs, coordinate microwave and ultrasound mode assisted extraction, can improve extraction efficiency and extractive content.
The extracting method of Aloe extract generally has: the sedimentation method: after with pulverizer, Aloe being smashed to pieces, with high speed centrifuge, precipitate.Nebulization: be drying to obtain by nebulization after aloe leaf is entered to cryoconcentration.
The extracting method of these extracts is conventionally known to one of skill in the art, at this, is not described in detail.In the extract of different extracting method gained, the content of effective ingredient can be slightly different, but it does not affect the effect of each extract in cleaning wound liquid.
Preferably, also comprise chitosan.The negative charge that erythrocyte itself has, with positive charge, can be adsorbed in chitosan molecule surface, thereby makes its coagulation caking, thereby reaches haemostatic effect; Meanwhile, the main component on chitosan molecule chain is glucamine, and it promotes wound healing effect excellent.
Preferably, also comprise vitamin C.Vitamin C is water solublity powerful antioxidant, and it participates in the synthetic of collagen protein, contributes to the healing of human body wound.Chitosan can promote blood coagulation, has sterilizing, promotes wound healing, absorbs Wound exudate, is difficult for the effects such as syneresis.
As further preferred, in cleaning wound liquid provided by the invention, the content of each component is: the active component of 3.25-7.4wt%; The osmotic pressure regulator of 0.6-0.9wt%, all the other are deionized water.Cleaning wound liquid effect in this content range is excellent.Preferred, the content of active component is 4.0-6.8wt%.
Cleaning wound liquid will reach does not have zest to human body, just requires its osmotic pressure to equate with the osmotic pressure of human plasma.In the present invention, regulate the osmotic pressure of cleaning wound liquid by osmotic pressure regulator, osmotic pressure regulator is preferably sodium chloride, potassium chloride, calcium chloride, sodium bicarbonate or sodium dihydrogen phosphate.More preferably adopt sodium chloride to regulate the osmotic pressure of cleaning wound liquid, consumption is 0.6-0.9%wt%, preferably 0.85-0.9wt%.
Preferably, the composition of described cleaning wound liquid and content are:
Sodium chloride 0.6-0.9wt%
Vitamin C 0.05-0.4wt%
Chitosan 2.0-3.0wt%
Folium Artemisiae Argyi extract 0.1-0.5wt%
Aloe extract 1.0-3.0wt%
Folium Menthae extract 0.1-0.5wt%
Deionized water surplus.
Simultaneously, the present invention also provides a kind of preparation method of above-mentioned cleaning wound liquid, first active component, osmotic pressure regulator is proportionally mixed, and is dissolved to mix homogeneously with deionized water, then add pH adjusting agent to regulate pH value to 6.5-7.5, encapsulation finally carries out disinfection.By its pH regulator to 6.5-7.5, to adapt to human body, in the present invention, pH value regulator is preferably NaOH or HCl.Disinfecting as known in those skilled in the art of medicine, is not described in detail at this.
Below by specific embodiment, the present invention is described in further detail.
embodiment 1
Each composition is mixed according to following ratio, with deionized water dissolving mix homogeneously.Regulating pH is the packing that carries out disinfection after 6.8.
Sodium chloride 0.85wt%
Vitamin C 0.2 wt%
Chitosan 2.0 wt%
Folium Artemisiae Argyi extract 0.4 wt%
Aloe extract 3.0 wt%
Folium Menthae extract 0.3 wt%
Deionized water surplus.
embodiment 2
Each composition is mixed according to following ratio, with deionized water dissolving mix homogeneously.Regulating pH is the packing that carries out disinfection after 7.2.
Sodium chloride 0.9 wt%
Vitamin C 0.25 wt%
Chitosan 2.5 wt%
Folium Artemisiae Argyi extract 0.3 wt%
Aloe extract 2.0 wt%
Folium Menthae extract 0.3 wt%
Deionized water surplus.
embodiment 3
Each composition is mixed according to following ratio, with deionized water dissolving mix homogeneously.Regulating pH is the packing that carries out disinfection after 7.5.
Sodium chloride 0.6wt%
Vitamin C 0.3wt%
Chitosan 2.8wt%
Folium Artemisiae Argyi extract 0.35wt%
Aloe extract 2.5wt%
Folium Menthae extract 0.4wt%
Deionized water surplus.
performance test
1, pain test:
Randomly draw 150 experimenters and adopt the cleaning wound liquid of embodiment 1-3 to carry out cleaning wound, 90% people does not feel the prick in cleaning process, and wound pain degree reduces;
Need to illustrate that in addition speed of wound healing is also fast than the healing rate that does not carry out cleaning wound.
2, bacteriostasis property test:
The cleaning wound liquid of embodiment 1-3 is joined in the culture dish of sterilizing with aseptic straw respectively, then add the agar culture medium of same volume, fully mix homogeneously.After culture medium is cooling, lid at alcohol burner front opening culture dish, with Inoculating needle, coat successively radially examination bacterium liquid (strain is staphylococcus aureus, staphylococcus epidermidis, escherichia coli, green pus bacterium and Candida albicans), cover the lid of culture dish, under 37 ℃ of constant temperature, cultivate 24-48 hour, observe the growing state of thalline, not contain the agar culture medium of cleaning wound liquid, make blank.
Through observing, have in the agar culture medium of the cleaning wound liquid that embodiment 1-embodiment 3 provides and find a small amount of staphylococcus aureus, staphylococcus epidermidis, escherichia coli, green pus bacterium and Candida albicans, be far smaller than not containing staphylococcus aureus, staphylococcus epidermidis, escherichia coli, green pus bacterium and Candida albicans quantity in the agar culture medium of cleaning wound liquid, illustrate that cleaning wound liquid provided by the invention has good fungistatic effect.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, therefore, as long as use any modification that the content of description of the present invention does, be equal to and replace and improvement etc., all should be included in protection scope of the present invention.
Claims (9)
1. a cleaning wound liquid, is characterized in that, comprises active component, osmotic pressure regulator and deionized water; Described active component is one or more in Folium Artemisiae Argyi extract, Aloe extract or Folium Menthae extract.
2. cleaning wound liquid according to claim 1, is characterized in that, described active component also comprises chitosan.
3. cleaning wound liquid according to claim 1, is characterized in that, described active component also comprises vitamin C.
4. according to the cleaning wound liquid described in claim 1-3 any one, it is characterized in that, each constituent content is: the active component of 3.25-7.4wt%; The osmotic pressure regulator of 0.6-0.9wt%, all the other are deionized water.
5. cleaning wound liquid according to claim 4, is characterized in that, the content of active component is 4.0-6.8wt%.
6. cleaning wound liquid according to claim 1, is characterized in that, described osmotic pressure regulator is sodium chloride, potassium chloride, calcium chloride, sodium bicarbonate or sodium dihydrogen phosphate.
7. cleaning wound liquid according to claim 1, is characterized in that, the composition of described cleaning wound liquid and content are:
Sodium chloride 0.6-0.9wt%
Vitamin C 0.05-0.4wt%
Chitosan 2.0-3.0wt%
Folium Artemisiae Argyi extract 0.1-0.5wt%
Aloe extract 1.0-3.0wt%
Folium Menthae extract 0.1-0.5wt%
Deionized water surplus.
8. the preparation method of a cleaning wound liquid claimed in claim 1, it is characterized in that, first active component, osmotic pressure regulator are proportionally mixed, and be dissolved to mix homogeneously with deionized water, then add pH adjusting agent to regulate pH value to 6.5-7.5, encapsulation finally carries out disinfection.
9. the preparation method of cleaning wound liquid according to claim 8, is characterized in that, described pH adjusting agent is NaOH or HCl.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201210203351.3A CN103505490B (en) | 2012-06-20 | 2012-06-20 | A kind of cleaning wound liquid |
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| CN201210203351.3A CN103505490B (en) | 2012-06-20 | 2012-06-20 | A kind of cleaning wound liquid |
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| CN103505490A true CN103505490A (en) | 2014-01-15 |
| CN103505490B CN103505490B (en) | 2016-04-27 |
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| CN201210203351.3A Active CN103505490B (en) | 2012-06-20 | 2012-06-20 | A kind of cleaning wound liquid |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104758202A (en) * | 2015-03-09 | 2015-07-08 | 胡建华 | A detergent containing plant extract products and a preparing method thereof |
| CN105107007A (en) * | 2015-08-26 | 2015-12-02 | 东莞市达庆医疗器械有限公司 | Cationic medical wound protecting dressing and method for preparing same |
| CN105126107A (en) * | 2015-09-21 | 2015-12-09 | 山东威高药业股份有限公司 | Liquid wound dressing |
| CN105477497A (en) * | 2014-09-19 | 2016-04-13 | 李玉兰 | Traditional Chinese medicine composition for hand wound treatment |
| CN105830766A (en) * | 2016-04-26 | 2016-08-10 | 江苏东珠景观股份有限公司 | Rejuvenation method of ancient and famous trees |
| CN105878673A (en) * | 2016-04-25 | 2016-08-24 | 李增梅 | Traditional Chinese medicine cleaning solution for nursing |
| CN106860401A (en) * | 2017-02-09 | 2017-06-20 | 林映津 | A kind of pure natural wound restoration agent |
| CN109674816A (en) * | 2018-12-17 | 2019-04-26 | 东元科技有限公司 | A kind of composite antibacterial aerosol and its preparation method and application |
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| CN1559580A (en) * | 2004-03-01 | 2005-01-05 | 福建省泉州亚泰制药有限公司 | Production technology of medicine for treating burn |
| CN1676142A (en) * | 2004-04-01 | 2005-10-05 | 上海银龙医药研究所 | Aloe wound-surface cleaning liquid, and its preparing method and use |
| CN102228485A (en) * | 2011-06-02 | 2011-11-02 | 叶松 | Composition for burn rehabilitation and preparation method thereof |
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Patent Citations (3)
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| CN1559580A (en) * | 2004-03-01 | 2005-01-05 | 福建省泉州亚泰制药有限公司 | Production technology of medicine for treating burn |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105477497A (en) * | 2014-09-19 | 2016-04-13 | 李玉兰 | Traditional Chinese medicine composition for hand wound treatment |
| CN104758202A (en) * | 2015-03-09 | 2015-07-08 | 胡建华 | A detergent containing plant extract products and a preparing method thereof |
| CN105107007A (en) * | 2015-08-26 | 2015-12-02 | 东莞市达庆医疗器械有限公司 | Cationic medical wound protecting dressing and method for preparing same |
| CN105126107A (en) * | 2015-09-21 | 2015-12-09 | 山东威高药业股份有限公司 | Liquid wound dressing |
| CN105878673A (en) * | 2016-04-25 | 2016-08-24 | 李增梅 | Traditional Chinese medicine cleaning solution for nursing |
| CN105830766A (en) * | 2016-04-26 | 2016-08-10 | 江苏东珠景观股份有限公司 | Rejuvenation method of ancient and famous trees |
| CN106860401A (en) * | 2017-02-09 | 2017-06-20 | 林映津 | A kind of pure natural wound restoration agent |
| CN109674816A (en) * | 2018-12-17 | 2019-04-26 | 东元科技有限公司 | A kind of composite antibacterial aerosol and its preparation method and application |
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| Publication number | Publication date |
|---|---|
| CN103505490B (en) | 2016-04-27 |
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