CN106860401A - A kind of pure natural wound restoration agent - Google Patents
A kind of pure natural wound restoration agent Download PDFInfo
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- CN106860401A CN106860401A CN201710070412.6A CN201710070412A CN106860401A CN 106860401 A CN106860401 A CN 106860401A CN 201710070412 A CN201710070412 A CN 201710070412A CN 106860401 A CN106860401 A CN 106860401A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
- A61K38/014—Hydrolysed proteins; Derivatives thereof from animals from connective tissue peptides, e.g. gelatin, collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
Abstract
The present invention relates to a kind of pure natural wound restoration agent.It is characterized in its component and its mass percent % including water soluble chitosan, tea tree ethereal oil, antibacterial peptide, plant extraction liquid, macromolecular collagen protein, micromolecular collagen, naturally occurring emulsifying agent and water：Water soluble chitosan 1% 8%；Tea tree ethereal oil 0.1% 2%；Antibacterial peptide 0.01 3%；Plant extraction liquid 2 20%；Macromolecular collagen protein 0.01% 2%；Micromolecular collagen 0.1 3%；Naturally occurring emulsifying agent 0.001% 0.05%, using deionized water as solvent.The method is characterized in that using water soluble chitosan, tea tree ethereal oil, antibacterial peptide restraining and sterilizing bacteria material, prevent wound microbes from infecting, supplement small molecule and macromolecular collagen protein simultaneously and promote the plant extraction liquid of cell growth, the material base for keeping the moisture of wound microenvironment and being repaired there is provided wound, while macromolecular collagen protein surface filming can slow down the volatilization of tea tree ethereal oil, so that the bactericidal anti-inflammatory effect of tea tree ethereal oil is more longlasting.Wound infection is avoided, accelerates wound reparation, reduce the generation of scar.
Description
Technical field
The present invention relates to renovation agent, more particularly to a kind of pure natural wound restoration agent.
Background technology
Wound frequent generation wound in healing festers, the phenomenon of necrosis, causes wound to repair in time, occurs secondary
Infection, while also creating scar.In order to avoid the infection of wound, antibiotic etc is widely used, however, with antibiosis
The problems such as extensive use of element even abuse, bacterial drug resistance, allergic reaction and environmental pollution, is increasingly serious, so as to trigger people
Very big concern to food and Environmental security.
In Chinese patent literature database, the A of Publication No. CN 103933062, poly- glycosaminoglycan polypeptide chelated iodine is combined
System solution and its preparation method, it, with shitosan, ε-polylysine, iodine as main active, is stabilizer structure with poloxamer to be
Into the network system solution with sterilized repair function.Raw material is the iodine with shitosan, epsilon-polylysine, KI as raw material
Changing the easy decomposability of potassium can influence the infection conditions of wound, and the formula performance of keeping humidity is poor, and replacing medicament may produce secondary
Wound, is unfavorable for wound reparation.
The content of the invention
It is an object of the invention to overcome drawbacks described above with deficiency, there is provided a kind of pure natural wound restoration agent, reach and avoid
Wound infection, accelerates wound reparation, reduces the purpose that scar is produced.
The purpose of the present invention is achieved through the following technical solutions：A kind of pure natural wound restoration agent, be characterized in including
Water soluble chitosan, tea tree ethereal oil, antibacterial peptide, plant extraction liquid, macromolecular collagen protein, micromolecular collagen, genuine milk
Agent and water, its component and its mass percent %：Water soluble chitosan 1%-8%；Tea tree ethereal oil 0.1%-2%；Antibacterial peptide
0.01-3%；Plant extraction liquid 2-20%；Macromolecular collagen protein 0.01%-2%；Micromolecular collagen 0.1-3%；Genuine milk
Agent 0.001%-0.05%, using deionized water as solvent.
It is preferred that the mass fraction of water soluble chitosan is 1-8 parts, the mass fraction of tea tree ethereal oil is 0.1-2 parts, antibacterial peptide
Mass fraction is 0.01-3 parts, and plant extraction liquid mass fraction is 2-20 parts, and large and small molecular collagen mass fraction is respectively
0.01-2 parts, 0.1-3 parts, naturally occurring emulsifying agent mass fraction is 0.001-0.05 parts, and the mass fraction of water is 80-100 parts；Institute
State antibacterial peptide and acquisition is extracted by fly-maggot protein；The plant extraction liquid is that centella extract solution or tea tree extract solution or aloe are extracted
Thing or the single addition of red pomegranate extract or mixing addition.
It is preferred that the mass fraction of water soluble chitosan is 3-6 parts, the mass fraction of tea tree ethereal oil is 0.1-1 parts, antibacterial peptide
Mass fraction is 0.1-2 parts, and plant extraction liquid mass fraction is 2-10 parts, and sized molecules collagen quality number is respectively
0.05-1 parts, 1-3 parts, naturally occurring emulsifying agent mass fraction is 0.01-0.05 parts, and the mass fraction of the water is 88-100 parts；
The antibacterial peptide is extracted by fly-maggot protein and obtained；The plant extraction liquid is that centella extract solution or tea tree extract solution or aloe carry
Take thing or the single addition of red pomegranate extract or mixing addition.
It is preferred that the mass fraction of water soluble chitosan is 5-7 parts, the mass fraction of tea tree ethereal oil is 0.5-1 parts, antibacterial peptide
Mass fraction is 0.5-2 parts, and plant extraction liquid mass fraction is 2-6 parts, and large and small molecular collagen mass fraction is 0.1-2
Part, 1-3 parts, naturally occurring emulsifying agent mass fraction is 0.001-0.01 parts, and the mass fraction of water is 82-90 parts；The antibacterial peptide
Extracted by fly-maggot protein and obtained；The plant extraction liquid is centella extract solution or tea tree extract solution or aloe extract or red stone
The single addition of pomegranate extract or mixing addition.
It is preferred that the mass fraction of water soluble chitosan is 2 parts, the mass fraction of tea tree ethereal oil is 0.6 part, antibacterial peptide quality
Number is 1 part, and plant extraction liquid mass fraction is 3 parts, and large and small molecular collagen mass fraction is 1 part, 2 parts, natural emulsified
Agent mass fraction is 0.003 part, and the mass fraction of water is 85 parts；The antibacterial peptide is extracted by fly-maggot protein and obtained；The plant
Thing extract solution is that centella extract solution or tea tree extract solution or aloe extract or the single addition of red pomegranate extract or mixing add
Plus.
It is preferred that the mass fraction of water soluble chitosan is 4 parts, the mass fraction of tea tree ethereal oil is 0.9 part, antibacterial peptide quality
Number is 1.5 parts, and plant extraction liquid mass fraction is 5 parts, and large and small molecular collagen mass fraction is 1.5 parts, 2.5 parts, day
Right emulsifying agent mass fraction is 0.008 part, and the mass fraction of water is 88 parts；The antibacterial peptide is extracted by fly-maggot protein and obtained；Institute
It is centella extract solution or tea tree extract solution or aloe extract or the single addition or mixed of red pomegranate extract to state plant extraction liquid
Close addition.
The method is characterized in that using water soluble chitosan, tea tree ethereal oil, antibacterial peptide restraining and sterilizing bacteria material prevents wound micro-
Biological infection, while supplementing small molecule and macromolecular collagen protein and promoting the plant extraction liquid of cell growth, keeps wound micro-
The moisture of environment and the material base repaired there is provided wound, while macromolecular collagen protein surface filming can slow down tea tree essence
The volatilization of oil, so that the bactericidal anti-inflammatory effect of tea tree ethereal oil is more longlasting.Wound infection is avoided, accelerates wound reparation, reduce scar
The generation of trace.
Water soluble chitosan is that the shitosan of small molecule is the band in adherent cell by penetrating into microbial cell
The cytoplasm of negative electricity, and there is flocculation, the normal physiological activity of cell is upset, so as to kill bacterium；And for gram
Positive bacteria, the shitosan mainly due to macromolecular is adsorbed in microbial cell surface, forms a floor height molecular film, prevents battalion
Material is supported to intracellular transport, so as to play sterilization and bacteriostasis effect.
Natural biological antibacterial peptide has hands over wide antibiotic property, particularly has lethal effect, Er Qiekang to multi-drug resistant bacteria
Bacterium peptide heat endurance exists（Activity can also be kept under 100 DEG C of heating conditions）And good water solubility, to the normal cell of higher mammal
Almost without toxic action, the ability with resistance trypsase or pepsin hydrolysis.Meanwhile, antibacterial peptide can also be by destroying disease
Malicious membrane structure, upsets the duplication of viral genetic information and the assembling of viral interference so as to reach anti-virus ability.
Tea tree ethereal oil is that main antimicrobial component terpenol has destruction and penetrates the ability of fat structure, so as to reach sterilized mesh
, the beauty and health care industry of the country is widely used at present.Using the co-action for treating produced between each composition in essential oil
Various tuberculosis have critically important meaning all the time, and monoterpene alcohol is belonged to if cineole (Cineole), and it is in essential oil with other
The synergy that composition is produced jointly is used for treating respiratory virus infection.
Collagen is human body nature albumen, has larger affinity, weaker to the protein molecule of skin surface
Antigenicity, good biocompatibility and biodegradable security, degradable absorption, adhesion strength are good, and a large amount of ammonia are rich in molecule
Base acid and hydrophilic group, with certain surface-active and good compatibility, simultaneously because contain substantial amounts of hydroxyl in its molecule,
Therefore it has fairly good moisturizing and promotion wound repair.
By adopting the above-described technical solution, the present invention has advantages below compared with prior art：
（1）The multiple natural bacteriostatic bactericide of this product, directly sprays or smears wound, can effectively kill microorganism and virus, and tool is wide
Spectrality；
（2）Food-grade marine source composition and natural plant extract, it is non-stimulated to skin, it is applicable to infant skin；
（3）Anti-inflammatory, moisturizing, moisturizing effect substantially, can be used for skin daily nursing as skin care item；
（4）The generation of scar, acne print is effectively reduced, cosmetic result is good.
Embodiment 1
Including water soluble chitosan, tea tree ethereal oil, antibacterial peptide, plant extraction liquid, macromolecular collagen protein, small molecule collagen egg
In vain, naturally occurring emulsifying agent and water, the mass fraction of the water soluble chitosan is 1 part, and the mass fraction of the tea tree ethereal oil is 0.1
Part, the antibacterial peptide mass fraction is 0.05 part, and the plant extraction liquid mass fraction is 5 parts, large and small molecular collagen matter
Amount number is respectively 2 parts, and 0.5 part, the naturally occurring emulsifying agent mass fraction is 0.001-0.05 parts, the mass parts of the water
Number is 95 parts；The antibacterial peptide is extracted by fly-maggot protein and obtained；The plant extraction liquid is：Centella extract solution and aloe are extracted
Thing mixing addition.
Embodiment 2
Including water soluble chitosan, tea tree ethereal oil, antibacterial peptide, plant extraction liquid, macromolecular collagen protein, small molecule collagen egg
In vain, naturally occurring emulsifying agent and water, the mass fraction of the water soluble chitosan is 5 parts, and the mass fraction of the tea tree ethereal oil is
0.5 part, the antibacterial peptide mass fraction is 0.1 part, and the plant extraction liquid mass fraction is 5 parts, large and small molecule collagen egg
White mass fraction is respectively 1 part, and 1 part, the naturally occurring emulsifying agent mass fraction is 0.01 part, and the mass fraction of the water is 95
Part；The antibacterial peptide is extracted by fly-maggot protein and obtained；The plant extraction liquid is：Centella extract solution, red pomegranate extract are mixed
Close addition.
Embodiment 3
Including water soluble chitosan, tea tree ethereal oil, antibacterial peptide, plant extraction liquid, macromolecular collagen protein, small molecule collagen egg
In vain, naturally occurring emulsifying agent and water, the mass fraction of the water soluble chitosan is 5 parts, and the mass fraction of the tea tree ethereal oil is 0.5
Part, the antibacterial peptide mass fraction is 0.1 part, and the plant extraction liquid mass fraction is 5 parts, large and small molecular collagen matter
Amount number is respectively 1 part, and 1 part, the naturally occurring emulsifying agent mass fraction is 0.01 part, and the mass fraction of the water is 95 parts；
The antibacterial peptide is extracted by fly-maggot protein and obtained；The plant extraction liquid is：Tea tree extract solution, aloe extract, red pomegranate are carried
Take thing mixing addition.
Above is the preferred embodiment of the present invention, it have been shown and described general principle of the invention and principal character with
And effect of the invention and advantage, it is that a kind of pure natural wound restoration agent that the present invention is provided is described in detail, not in detail
Describe bright technical characteristic in detail and be known technology.Specific case used herein is carried out to principle of the invention and implementation method
Illustrate, the explanation of this embodiment is only intended to help and understands the method for the present invention and its core concept.It should be pointed out that for
For the technical staff of the industry, it should be appreciated that the present invention is not limited to the above embodiments, in above-described embodiment and specification
What is described merely illustrates the principles of the invention, and without departing from the spirit and scope of the present invention, the present invention also has various
Changes and improvements, these changes and improvements all fall within the protetion scope of the claimed invention, it is all according to above-mentioned design made it is similar
Like changing, ought to belong to of the invention and cover content, the scope of protection of present invention was by appending claims and its waited
Effect thing is defined.
Claims (6)
1. a kind of pure natural wound restoration agent, be characterized in including water soluble chitosan, tea tree ethereal oil, antibacterial peptide, plant extraction liquid,
Macromolecular collagen protein, micromolecular collagen, naturally occurring emulsifying agent and water, its component and its mass percent %：Water soluble shells
Glycan 1%-8%；Tea tree ethereal oil 0.1%-2%；Antibacterial peptide 0.01-3%；Plant extraction liquid 2-20%；Macromolecular collagen protein
0.01%-2%；Micromolecular collagen 0.1-3%；Naturally occurring emulsifying agent 0.001%-0.05%, using deionized water as solvent.
2. a kind of pure natural wound restoration agent according to claim 1, the mass fraction for being characterized in water soluble chitosan is
1-8 parts, the mass fraction of tea tree ethereal oil is 0.1-2 parts, and antibacterial peptide mass fraction is 0.01-3 parts, plant extraction liquid mass fraction
It it is 2-20 parts, large and small molecular collagen mass fraction is respectively 0.01-2 parts, 0.1-3 parts, naturally occurring emulsifying agent mass fraction is
0.001-0.05 parts, the mass fraction of water is 80-100 parts；The antibacterial peptide is extracted by fly-maggot protein and obtained；The plant carries
It is centella extract solution or tea tree extract solution or aloe extract or the single addition of red pomegranate extract or mixing addition to take liquid.
3. a kind of pure natural wound restoration agent according to claim 1, is characterized in the mass fraction of water soluble chitosan
It it is 3-6 parts, the mass fraction of tea tree ethereal oil is 0.1-1 parts, and antibacterial peptide mass fraction is 0.1-2 parts, plant extraction liquid mass parts
Number is 2-10 parts, and sized molecules collagen quality number is respectively 0.05-1 parts, 1-3 parts, and naturally occurring emulsifying agent mass fraction is
0.01-0.05 parts, the mass fraction of the water is 88-100 parts；The antibacterial peptide is extracted by fly-maggot protein and obtained；The plant
Extract solution is centella extract solution or tea tree extract solution or aloe extract or the single addition of red pomegranate extract or mixing addition.
4. a kind of pure natural wound restoration agent according to claim 1, is characterized in the mass fraction of water soluble chitosan
It it is 5-7 parts, the mass fraction of tea tree ethereal oil is 0.5-1 parts, and antibacterial peptide mass fraction is 0.5-2 parts, plant extraction liquid mass parts
Number is 2-6 part, and large and small molecular collagen mass fraction is 0.1-2 parts, and 1-3 parts, naturally occurring emulsifying agent mass fraction is
0.001-0.01 parts, the mass fraction of water is 82-90 parts；The antibacterial peptide is extracted by fly-maggot protein and obtained；The plant extract
Liquid is centella extract solution or tea tree extract solution or aloe extract or the single addition of red pomegranate extract or mixing addition.
5. a kind of pure natural wound restoration agent according to claim 1, is characterized in the mass fraction of water soluble chitosan
It is 2 parts, the mass fraction of tea tree ethereal oil is 0.6 part, and antibacterial peptide mass fraction is 1 part, and plant extraction liquid mass fraction is 3 parts,
Large and small molecular collagen mass fraction is 1 part, and 2 parts, naturally occurring emulsifying agent mass fraction is 0.003 part, the mass fraction of water
It is 85 parts；The antibacterial peptide is extracted by fly-maggot protein and obtained；The plant extraction liquid is centella extract solution or tea tree extract solution
Or aloe extract or the single addition of red pomegranate extract or mixing addition.
6. a kind of pure natural wound restoration agent according to claim 1, is characterized in the mass fraction of water soluble chitosan
It it is 4 parts, the mass fraction of tea tree ethereal oil is 0.9 part, and antibacterial peptide mass fraction is 1.5 parts, and plant extraction liquid mass fraction is 5
Part, large and small molecular collagen mass fraction is 1.5 parts, and 2.5 parts, naturally occurring emulsifying agent mass fraction is 0.008 part, the matter of water
Amount number is 88 parts；The antibacterial peptide is extracted by fly-maggot protein and obtained；The plant extraction liquid is centella extract solution or tea tree
Extract solution or aloe extract or the single addition of red pomegranate extract or mixing addition.
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| CN108273044A (en) * | 2018-04-02 | 2018-07-13 | 广州赛莱拉干细胞科技股份有限公司 | The Wound healing compositions of the antibacterial peptide of mucus containing Scioenops ocellatus |
| CN109045253A (en) * | 2018-08-09 | 2018-12-21 | 高昕文 | Scar liquid is removed in a kind of whitening |
| CN111110832A (en) * | 2018-10-15 | 2020-05-08 | 王茂松 | A preparation containing snail extractive solution and Chinese Holly extract for treating wound and scar, and its preparation method |
| CN109908066A (en) * | 2019-04-04 | 2019-06-21 | 派能生物科技（深圳）有限公司 | A kind of preparation method of the composition for skin repair |
| CN109908066B (en) * | 2019-04-04 | 2022-01-21 | 合肥贝壳派创新科技有限公司 | Preparation method of composition for skin repair |
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