CN102246794B - A kind of composition of killing microorganisms - Google Patents
A kind of composition of killing microorganisms Download PDFInfo
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- CN102246794B CN102246794B CN201110151341.5A CN201110151341A CN102246794B CN 102246794 B CN102246794 B CN 102246794B CN 201110151341 A CN201110151341 A CN 201110151341A CN 102246794 B CN102246794 B CN 102246794B
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Abstract
The present invention relates to a kind of composition of killing microorganisms, be mainly used in the sterilization of health hand-wrist bones, surgery hand-wrist bones, skin, mucous membrane, also can be used for killing of article surface microorganism, with hexamethylene and ethanol for major antibacterial active ingredient, combination sterilizing synergistic agent isopropyl alcohol, concentration 3 ~ 54g/L that the concentration of ethanol is 79 ~ 467g/L, the concentration of hexamethylene is 0.01 ~ 15g/L, isopropyl alcohol, humectant, stabilizing agent, thickener etc. can be added as required, to make different formulations simultaneously; Said composition has that bactericidal effect is good, speed is fast, disposable, stability is high, slow down the stimulation of product to skin, the advantage of moisturizing skin care.
Description
Technical field
The present invention relates to for hand, skin, mucous membrane, and comprise food kitchenware article surface can be disposable, the composition of efficient killing microorganisms.
Background technology
Due to increasing the weight of of global warming and environmental pollution, the variation of pathogenic microorganisms is accelerated; The abuse of various antibiotic, antiviral drugs; to the virus of antibiotic and the immunity of enantiopathy cytotoxic drug; and the generation of the pathogenic microorganisms of highly pathogenic highly infective is also in quickening; reply and control caused by pathogenic microorganisms infectious disease break out with popular; just must control source of infection, cut off route of transmission and protection Susceptible population; wherein, cutting off route of transmission is safe and reliable important means.
Different from traditional antimicrobial products, disposable product overcomes following difficulty: do not limit by water source, can use whenever and wherever possible; The material used can not damage skin and article; The material used, can not cause the appearance of anti-medicine microorganism as much as possible, and that is, antimycotic medicine, antiviral drug etc. can not appear in washing-free antibacterial, sterile products.The material of traditional removing pathogenic microorganisms, because of its exist skin irritatin, allergy, bactericidal effect poor, stain the reason such as skin, bleaching article, disposable sterilization cannot be used for, as phenols, high concentration alcohols, heavy metal salt, surfactant, quaternary ammonium compound, oxide (comprising peroxide, hydrogen peroxide, bleaching water etc.), halogen-containing material (as Iodophor etc.) and the small molecule aldehyde compound destroying DNA and RNA etc.
Methylguanidine in poly hexamethylene biguanide (PHMB) compound has very high activity, easily by bacterium, virus adsorb, directly act on microorganism, inhibit the division copy function of bacterium, virus, it plugs the respiration channel of microorganism in the formation of microorganism body surface polymer, and microorganism is choked to death.Meanwhile, its high molecular polymer structure makes the effective active of guanidine radicals be improved, and bacterium not easily produces drug resistance.
This compound, in the systematic Study of European medicine industry by the research of the research of the studies on acute toxicity of system, human body toxicological study, Study on Subchronic, chronic toxicity and carcinogenic possibility, genotoxicity, reviviscence toxicity research and metabolism, finally draws poly hexamethylene biguanide systematic toxicology conclusion: 1. low acute toxicity; 2. when when normal using dosage, there is low skin and eye irritation; 3. low long-term toxicity; 4. without genotoxicity; 5. non-teratogenesis; 6. proved without reviviscence toxicity by the research between two generations; 7. for the mankind, non-carcinogenic potential drug is belonged to.
The bactericidal mechanism of ethanol, mainly by the lipid in removing Knowledge On Bacterial Biofilm, makes microorganism protein denaturation solidify and plays sterilization or bacteriostasis, be widely used in sterilization field.With poly hexamethylene biguanide compatibility, can synergy be produced, improve sterilization biologically active.Add isopropyl alcohol simultaneously, good fit with above-mentioned system, produce better bactericidal activity.The volatility of ethanol and isopropyl alcohol is extremely strong, and product is with rear dry and comfortable rapidly.
At present, Chinese patent literature has disclosed many disposable Quick disinfection products that can be used for hand, skin, mucous membrane and article surface, and wherein part has selected alcohols, polymerization guanidine class etc. to be bactericidal active ingredient.
Application number is the patent application document of 200910114010.7, disclose a kind of by polyhexamethylene hydrochloric acid biguanides and ethanol be major antibacterial active ingredient, polyoxyethylene nonylphenol ether is the skin degerming product of surfactant, its ethanol percentage by weight 50% ~ 60%, polyhexamethylene hydrochloric acid biguanides 0.52% ~ 0.63%; Application number is the Chinese patent of 200980108019.5, disclose a kind of alcohol antimicrobial skin sanitizing compositions comprising cationic compatible thickeners, it comprises alcohol, thickened systems, cationic compound (as poly hexamethylene biguanide) etc. at least about 60%, and its concentration is higher.
Application number is the Chinese patent application file of 200680032102.5, disclose a kind of by poly hexamethylene biguanide, secondary antimicrobial, and optional organic acid, process auxiliary agent as the antimicrobial compositions of alcohol and surfactant composition, it realized about 3 log in 30 minutes
10the killing effect of reduction, or at least 1 log in the time of 5 ~ 10 minutes
10the minimizing of microorganism.
Application number is the Chinese patent application file of 03139745.x, disclose a kind of sterile products be made up of 95% ethanol 35% ~ 60%, poly hexamethylene biguanide 0.5% ~ 1.0%, flavouring agent 0.01 ~ 0.5%, water surplus, it is for skin degerming, does not add any moisturizing ingredient.
Application number is the Chinese patent application file of 200910114009.4, disclose a kind of formula of liquid disinfectant, with PHMB (also known as poly hexamethylene biguanide) for principle active component, polyoxyethylene nonylphenol ether is selected to be surfactant, add essence to make, this disinfectant to Escherichia coli effect 15min, average kill oncomelania > 5.00; To Candida albicans effect 15min, average kill oncomelania > 3.51.
Foregoing invention, or containing a large amount of alcohols material, for a long time for the sterilization of hand, skin, may cause the dry lack of water of skin, rubescent, chap, and to the transport of sterile products, store and propose higher requirement; Or bactericidal effect is general, needs the long period just can reach or cannot reach and the ability of the quick kill bacteria of present composition equivalence with virus at all; Or formula components is on the high side, preparation process is loaded down with trivial details, complex process.
Summary of the invention
The object of the invention is to: the composition that a kind of killing microorganisms is provided, for hand, skin, mucous membrane antibiotic and sterilizing and comprise the killing of article surface microorganism of food kitchenware.Have bactericidal effect good, can disposable, advantage that stability is high, the occasion such as daily life, tourism trip, hotel, hotel, hospital, kindergarten, public transport, pet sterilization can be widely used in.
The invention provides the composition of the quick killing microorganisms of a kind of energy, overcome the deficiencies in the prior art, have raw material simple, production cost is low, the simple advantage of preparation technology; Under the prerequisite ensureing efficient sterilizing effect, the preferred bactericidal active ingredient compared with low dosage, total alcohol amount declines to a great extent, and shipping storage is convenient; Simultaneously according to the needs of purposes and formulation, add humectant, thickener etc., slow down product to the stimulation of skin, moisturizing skin care, make sterile products in skin and article surface film forming, thus extend the lasting bacteriostasis of sterile products.
Technical scheme of the present invention:
A composition for killing microorganisms, comprises each component and concentration is in composition:
| Ethanol | 79~467 g/L |
| Poly hexamethylene biguanide or its salt | 0.01~15 g/L |
| Isopropyl alcohol | 3~54 g/L |
| Water | Surplus |
In above-mentioned composition, the concentration of bactericidal active constituent ethanol is preferably 238 ~ 447 g/L, is more preferably 379 ~ 427 g/L,
Most preferably 406 g/L; The concentration of hexamethylene is preferably 0.1 ~ 10g/L, is more preferably 2 ~ 4 g/L, most preferably 3 g/L; Concentration preferably 27 ~ 51 g/L of sterilizing synergistic agent isopropyl alcohol, are more preferably 33 ~ 45 g/L, most preferably 39 g/L.According to formulation and purposes needs, any one in humectant or stabilizing agent or thickener or odor mask or its combination in composition, can also be added.
Above-mentioned composition can with liquid preparation, spray or the form applying/be adsorbed in as required on base material, for the antibiotic and sterilizing of hand, skin, mucous membrane, and comprises the killing of article surface microorganism of food kitchenware.
Apply/be adsorbed in the form on base material, include but are not limited to the annex solution as wet sanitary napkins, wet wiping towel, hand towel, facial towel.
If for hand, antibacterial skin sterilization, skin conditioner can be added in composition as humectant or stabilizing agent or appropriate thickener etc.Add skin conditioner in hand, skin antiseptic, the stimulation of disinfectant to skin can not only be reduced, also can extend drying time, make disinfectant be easy to smear, strengthen antibacterial effect.
If for article surface sterilization, can thickener, stabilizing agent etc. be added in composition.
According to special requirement, in composition, appropriate odor mask can be added, as essence, single-propylene glycol.
Described in composition, humectant includes but not limited to: polyalcohol is as one or more any combination in glycerine or propane diols, polyethylene glycol, pyrrolidone sodium carboxylate, amide-type humectant, mucopolysaccharides, panthenol, jojoba oil, natural plant extracts, hyaluronic acid, double hyaluronic acid, ceramide, silk-fibroin/SP class humectant, collagen, glucosan derivative, chitin Chitosan-phospholipid complex, 1-alkyl glycerol ether compound, BSJ15.
Stabilizing agent described in composition includes but not limited to bronopol, acid-base modifier.
Thickener described in composition include but not limited to hydroxyethylcellulose, hydroxypropyl cellulose, HPMC, polyethylene glycol, compound based on polyethylene glycol, polyacrylamide, polyacrylamide methyl propane sulfonic acid, butylation PVP, Natrulon H-10 behenate/eicosane diacid ester, acrylate copolymer, based on one or more any combination in the polymer of acrylate.
The present invention adopts ethanol and poly hexamethylene biguanide or its salt as fungicide active ingredient, and add isopropyl alcohol is sterilizing synergistic agent simultaneously, and advantage is:
1, raw material are simple and easy to get, and production cost is low, preparation technology is simple;
2, tradition is solved containing the high problem causing transporting, storage cost significantly increases of alcohol amount total in alcohol sterile products;
3, alcohol content is low, meanwhile, adds moisturizing ingredient, thus overcome dry skin lack of water, rubescent, crack that traditional disinfection product causes when composition of the present invention is used for skin degerming;
4, bactericidal effect is good, and preferred formula also has stronger ability of killing to AIDS virus etc., is applicable to that all kinds of personnel's hand, skin, mucous membrane are antibacterial, sterilization, and comprises the killing of microorganism of article surface of food kitchenware;
5, can be used for disposable formulation product.
Embodiment
Further illustrate technical solution of the present invention below in conjunction with specific embodiment, these embodiments can not be interpreted as it is restriction to technical solution.
Embodiment 1
Prepare thimerosal according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol (volume ratio is added successively under stirring, being converted into mass ratio is 92.3%, 440kg, isopropyl alcohol 39kg, glycerine 10kg, hypromellose cellulose solution down together), finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
Wherein, glycerine has the effect of moisturizing skin care, can slow down the stimulation of alcohols solvent to skin; HPMC can make this thimerosal in skin and article surface film forming, extends the antibacterial time; Bronopol uses used as stabilizers in this product.
In composite formula, the mass percent being equivalent to bactericidal active constituent ethanol is 45.6%; The mass percent of hexamethylene is 0.33%; The mass percent of isopropyl alcohol is 4.3%.
After testing, under 20 DEG C ± 1 DEG C condition, composition stoste effect 1.0 min, to the average kill oncomelania > 5.00 of Escherichia coli, to the average kill oncomelania > 5.00 of staphylococcus aureus, to the average kill oncomelania > 5.00 of pseudomonas aeruginosa, to the average kill oncomelania > 4.00 of Candida albicans, the average kill oncomelania > 4.00 of infected by influenza, stability meets the requirement of Ministry of Health of the People's Republic of China's " disinfection technology standard " (version in 2002), the term of validity 24 months.
Through inspection, to chmice acute per os LD
50> 5000 mg/kg body weight, true border is nontoxic; Repeatedly intact skin irritant test total mark mean value is 0, skin irritation index < 0.5, and stimulus intensity belongs to nonirritant; To PCEMNR without causing micronucleus effect; Maximum illeffects dosage of not observing is 1000 mg/kg body weight.
Embodiment 2
The thimerosal prepared, with example 1, is adsorbed in non-woven fabrics as wet tissue annex solution, makes wet sanitary napkins by the preparation method of this sanitizing composition.
After testing, under 20 DEG C ± 1 DEG C condition, wet sanitary napkins effect 1 min, 100% is to colibacillary average kill ratio, 100% is to the average kill ratio of staphylococcus aureus, 100% is to the average kill ratio of pseudomonas aeruginosa, be 99.94% to the average kill ratio of hemolytic streptococcus, be 99.91% to the average kill ratio of Candida albicans, the average kill oncomelania > 3.00 of infected by influenza, to the deactivation logarithm value > 3.00 of HIV virus.
Hand-wrist bones field trial: through 30 person-times of repeated tests, wet sanitary napkins effect 1min, to the average kill oncomelania > 1.00 of the natural bacteria on hand surface.
Escherichia coli Simulation field trial: prove through 30 sampling tests, pollutes colibacillary body surface 1min with wet sanitary napkins wiping, and the Escherichia coli average kill ratio polluted body surface is 100%.
Keep the condition of >=75% in relative moisture under, after placing 14 days (be equivalent to room temperature and place 1 year) in 54 DEG C of insulating boxs, wet sanitary napkins effect 1min is still 100% to colibacillary average kill ratio.
Embodiment 3
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 0.5kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 5kg, 95% ethanol 258kg, isopropyl alcohol 9kg, glycerine 12kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 4
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 1.5kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.5kg, the 20% hexamethylene aqueous solution 13.5 kg, 95% ethanol 414 kg, isopropyl alcohol 27kg, glycerine 5kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 5
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 0.3kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.2kg, 20% hexamethylene aqueous solution 16.5kg, 95% ethanol 465kg, isopropyl alcohol 45kg, glycerine 8kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 6
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 0.5kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.6kg, the 20% hexamethylene aqueous solution 22.5 kg, 95% ethanol 440kg, isopropyl alcohol 54kg, glycerine 4kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 7
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 0.2kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.7kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 258 kg, isopropyl alcohol 54 kg, glycerine 15kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 8
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.8kg, the 20% hexamethylene aqueous solution 15 kg, 95% ethanol 258 kg, isopropyl alcohol 45 kg, glycerine 10kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 9
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 0.7kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.9kg, the 20% hexamethylene aqueous solution 14.5 kg, 95% ethanol 430 kg, isopropyl alcohol 38 kg, glycerine 6kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 10
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 1.2kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 1.2kg, the 20% hexamethylene aqueous solution 14 kg, 95% ethanol 420 kg, isopropyl alcohol 37 kg, glycerine 7kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 11
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 1.3kg, the 20% hexamethylene aqueous solution 15.5 kg, 95% ethanol 450 kg, isopropyl alcohol 40 kg, glycerine 4kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 12
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 2kg, the 20% hexamethylene aqueous solution 16 kg, 95% ethanol 460 kg, isopropyl alcohol 41 kg, glycerine 8kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 13
According to following steps preparing product: add 200L purified water in preparing tank, bronopol 0.5kg, 20% hexamethylene aqueous solution 12kg, 95% ethanol 480kg, isopropyl alcohol 51kg, glycerine 10kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 14
According to following steps preparing product: add 200L purified water in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 435kg, isopropyl alcohol 38 kg, glycerine 5kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 15
According to following steps preparing product: add 200L purified water in preparing tank, 20% hexamethylene aqueous solution 11kg, 95% ethanol 400kg, isopropyl alcohol 30kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 16
According to following steps preparing product: add 200L purified water in preparing tank, 20% hexamethylene aqueous solution 5kg, 95% ethanol 506kg, isopropyl alcohol 9kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 17
According to following steps preparing product: add 200L purified water in preparing tank, 20% hexamethylene aqueous solution 13.5kg, 95% ethanol 465kg, isopropyl alcohol 27kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 18
According to following steps preparing product: add 200L purified water in preparing tank, 20% hexamethylene aqueous solution 16.5kg, 95% ethanol 414kg, isopropyl alcohol 45kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 19
According to following steps preparing product: add 200L purified water in preparing tank, 20% hexamethylene aqueous solution 22.5kg, 95% ethanol 258kg, isopropyl alcohol 54kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 20
According to following steps preparing product: add 200L purified water in preparing tank, the 20% hexamethylene aqueous solution 14.5 kg, 95% ethanol 450 kg, isopropyl alcohol 38kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 21
According to following steps preparing product: add 200L purified water in preparing tank, the 20% hexamethylene aqueous solution 14 kg, 95% ethanol 460 kg, isopropyl alcohol 37 kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 22
According to following steps preparing product: add 200L purified water in preparing tank, the 20% hexamethylene aqueous solution 15.5 kg, 95% ethanol 430 kg, isopropyl alcohol 40 kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 23
According to following steps preparing product: add 200L purified water in preparing tank, the 20% hexamethylene aqueous solution 16 kg, 95% ethanol 420 kg, isopropyl alcohol 41 kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 24
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 0.5kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.2kg, 20% hexamethylene aqueous solution 10kg, 95% ethanol 410kg, isopropyl alcohol 52kg, glycerine 8kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 25
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 0.9kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.27kg, 20% hexamethylene aqueous solution 40kg, 95% ethanol 506kg, isopropyl alcohol 15kg, glycerine 9kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 26
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 1.1kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.33kg, 20% hexamethylene aqueous solution 30kg, 95% ethanol 435kg, isopropyl alcohol 20kg, glycerine 11kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 27
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 1.5kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.4kg, 20% hexamethylene aqueous solution 25kg, 95% ethanol 430kg, isopropyl alcohol 32kg, glycerine 12kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 28
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 0.5 kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 20kg, 95% ethanol 360kg, isopropyl alcohol 36kg, glycerine 10kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 29
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, the 20% hexamethylene aqueous solution 19 kg, 95% ethanol 310 kg, isopropyl alcohol 42 kg, glycerine 5kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 30
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 0.2kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, the 20% hexamethylene aqueous solution 17 kg, 95% ethanol 500 kg, isopropyl alcohol 43 kg, glycerine 1 kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 31
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 18kg, 95% ethanol 490kg, isopropyl alcohol 44kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 32
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.200L purified water is added in preparing tank, 20% hexamethylene aqueous solution 3kg, 95% ethanol 290kg, isopropyl alcohol 47kg, glycerine 10kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 33
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into C10-30 alkylol acrylamide acid esters cross-linked polymer (one of acrylate copolymer) 2kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 7kg, 95% ethanol 160kg, isopropyl alcohol 49kg, glycerine 10 kg, alkylol acrylamide acid esters cross-linked polymer solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 34
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 0.5kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, Sensiva SC50 (a kind of 1-alkyl glycerol ether compound) 10kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 35
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Natrulon H-10 behenate/eicosane diacid ester 50kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, Sensiva SC50 (a kind of 1-alkyl glycerol ether compound) 10kg, ethohexadiol 3kg, Natrulon H-10 behenate/eicosane diacid ester solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 36
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, BSJ15 50 kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 37
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 0.5 kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, PPG-20 methyl ether (a kind of glucosan derivative) 50 kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 38
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 0.5 kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, extract solution from aloe 1 kg, glycerine 2 kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 39
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 0.5 kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, jojoba oil 0.5 kg, marine algae extract 2 kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 40
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 0.5 kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, hyaluronic acid 5 kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 41
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 0.5 kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, shitosan 10 kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 42
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 0.5 kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, Cer EOS kg, glycerine 2kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 43
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 0.5 kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, SP 5 kg, glycerine 5 kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 44
Prepare spray according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, glycerine 10kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 45
Prepare spray according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 5kg, 95% ethanol 258kg, isopropyl alcohol 9kg, glycerine 10kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 46
Prepare spray according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, the 20% hexamethylene aqueous solution 13.5 kg, 95% ethanol 414 kg, isopropyl alcohol 27kg, glycerine 10kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 47
Prepare spray according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 16.5kg, 95% ethanol 465kg, isopropyl alcohol 45kg, glycerine 10kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 48
Prepare spray according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, the 20% hexamethylene aqueous solution 22.5 kg, 95% ethanol 440kg, isopropyl alcohol 54kg, glycerine 10kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 49
Prepare spray according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 258 kg, isopropyl alcohol 54 kg, glycerine 10kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 50
Prepare spray according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, the 20% hexamethylene aqueous solution 15 kg, 95% ethanol 258 kg, isopropyl alcohol 45 kg, glycerine 10kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 51
Prepare spray according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 0.5 kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, glycerine 10kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 52
Prepare spray according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, glycerine 5kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 53
Spray is prepared: in preparing tank, add 200L purified water according to following steps, bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, glycerine 10kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 54
Spray is prepared: in preparing tank, add 200L purified water according to following steps, bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, glycerine 5kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 55
Prepare gel according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into hydroxyethylcellulose 200kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, pyrrolidone sodium carboxylate 50kg, hydroxyethyl cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
Embodiment 56
Prepare gel according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into hydroxyethylcellulose 150kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, glycerine 10kg, hydroxyethyl cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
Embodiment 57
Prepare gel according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into hydroxyethylcellulose 100kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 13kg, 95% ethanol 462kg, isopropyl alcohol 35kg, glycerine 15kg, hydroxyethyl cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
Embodiment 58
Prepare gel according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into hydroxypropyl cellulose 180kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, glycerine 15kg, hydroxypropyl cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
Embodiment 59
Prepare gel according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into polyethylene glycol 190kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, glycerine 1 kg, polyglycol solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
Embodiment 60
Prepare gel according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into polyethylene glycol 190kg and be stirred to transparent clarification.200L purified water is added in preparing tank, add under stirring that bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, glycerine 1 kg, essence are appropriate, polyglycol solution successively, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
Embodiment 61
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 0.5 kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 20kg, 95% ethanol 334kg, isopropyl alcohol 51 kg, glycerine 5 kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 62
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 0.5 kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 10kg, 95% ethanol 463kg, isopropyl alcohol 33 kg, glycerine 5 kg, single-propylene glycol 50kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 63
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 1 kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 484kg, isopropyl alcohol 41 kg, glycerine 3 kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The product prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 64
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 10kg, 95% ethanol 411kg, isopropyl alcohol 34kg, glycerine 5kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
Embodiment 65
Spray is prepared: in preparing tank, add 200L purified water according to following steps, bronopol 0.3kg, 20% hexamethylene aqueous solution 75kg, 95% ethanol 86kg, isopropyl alcohol 54kg, glycerine 5kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 66
Spray is prepared: in preparing tank, add 200L purified water according to following steps, bronopol 0.5kg, 20% hexamethylene aqueous solution 50kg, 95% ethanol 258kg, isopropyl alcohol 54kg, glycerine 10kg is added successively under stirring, essence is appropriate, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 67
Spray is prepared: in preparing tank, add 200L purified water according to following steps, bronopol 0.3kg, 20% hexamethylene aqueous solution 20kg, 95% ethanol 386kg, isopropyl alcohol 3kg, glycerine 5kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 68
Spray is prepared: in preparing tank, add 200L purified water according to following steps, bronopol 0.5kg, 20% hexamethylene aqueous solution 10kg, 95% ethanol 440kg, isopropyl alcohol 6kg, double hyaluronic acid 2kg, glycerine 5kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 69
Spray is prepared: in preparing tank, add 200L purified water according to following steps, bronopol 0.5kg, 20% hexamethylene aqueous solution 0.5kg, 95% ethanol 400kg, isopropyl alcohol 39kg, glycerine 9kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 70
Spray is prepared: in preparing tank, add 200L purified water according to following steps, bronopol 0.5kg, 20% hexamethylene aqueous solution 0.05kg, 95% ethanol 440kg, isopropyl alcohol 39kg, glycerine 10kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 71
Spray is prepared: in preparing tank, add 200L purified water according to following steps, bronopol 0.5kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg, glycerine 10kg is added successively under stirring, single-propylene glycol 50kg, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 72
According to following steps preparing product: add 50L purified water in stainless steel cask, bronopol 0.3kg, 20% hexamethylene aqueous solution 10kg, 95% ethanol 400kg, isopropyl alcohol 39kg, butylation PVP350Kg is added successively under stirring, finish and stir to clarify, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Claims (6)
1. a composition for killing microorganisms, is characterized in that: comprise each component in composition and concentration is
2. composition according to claim 1, is characterized in that: comprise each component in composition and concentration is
3. composition according to claim 2, is characterized in that: comprise each component in composition and concentration is
4. a preparation, is characterized in that: comprise any one in the arbitrary described composition of claim 1-3 and humectant or stabilizing agent or thickener or odor mask or its combination; Humectant comprises one or more any combination in polyalcohol glycerine or propane diols, polyethylene glycol, pyrrolidone sodium carboxylate, amide-type humectant, mucopolysaccharides, panthenol, jojoba oil, natural plant extracts, hyaluronic acid, double hyaluronic acid, ceramide, silk-fibroin/SP class humectant, collagen, glucosan derivative, chitin Chitosan-phospholipid complex, 1-alkyl glycerol ether compound; Stabilizing agent comprises bronopol, acid-base modifier; Thickener comprise hydroxyethylcellulose, hydroxypropyl cellulose, HPMC, polyethylene glycol, compound based on polyethylene glycol, polyacrylamide, polyacrylamide methyl propane sulfonic acid, butylation PVP, Natrulon H-10 behenate/eicosane diacid ester, acrylate copolymer, based on one or more any combination in the polymer of acrylate; Odor mask comprises essence, single-propylene glycol.
5. preparation according to claim 4, is characterized in that: the form of preparation is liquid preparation, gel, spray or coating/be adsorbed on base material.
6. coating according to claim 5/the be adsorbed in form on base material, using the annex solution of composition as wet sanitary napkins, wet wiping towel, hand towel, facial towel.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110151341.5A CN102246794B (en) | 2011-06-08 | 2011-06-08 | A kind of composition of killing microorganisms |
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|---|---|---|---|
| CN201110151341.5A CN102246794B (en) | 2011-06-08 | 2011-06-08 | A kind of composition of killing microorganisms |
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| CN102246794A CN102246794A (en) | 2011-11-23 |
| CN102246794B true CN102246794B (en) | 2015-08-19 |
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| CN102475513B (en) * | 2011-12-12 | 2013-07-10 | 浙江瑞邦日化有限公司 | Hydrogel type hygiene wet tissue and preparation method thereof |
| CN102846717A (en) * | 2012-08-29 | 2013-01-02 | 铜陵洁雅生物科技股份有限公司 | Disposable hand disinfection wet wipe |
| CN103893794A (en) * | 2012-12-25 | 2014-07-02 | 青岛海芬海洋生物科技有限公司 | Footwear sterilizing and deodorizing spray agent containing marine biological sterilizing ingredient |
| CN105051123A (en) * | 2013-02-21 | 2015-11-11 | 科林斯波特公司 | Treatment of frequently touched surfaces to improve hygiene |
| CN103190399A (en) * | 2013-03-30 | 2013-07-10 | 江苏健裕健康医疗器械有限公司 | Medical isopropanol sterilizing disinfectant |
| CN103283722A (en) * | 2013-07-02 | 2013-09-11 | 宁波华欣医疗器械有限公司 | Compound disinfectant for hospital and application thereof |
| CN103340816B (en) * | 2013-07-17 | 2014-09-24 | 深圳市妍倩科技有限公司 | Special private care wet tissue for women |
| CN105284860A (en) * | 2014-06-16 | 2016-02-03 | 盐城市聚科化工有限公司 | Multiple-effect antibacterial agent composition for wet tissue and production method thereof |
| CN105362103A (en) * | 2015-12-19 | 2016-03-02 | 南京巨鲨显示科技有限公司 | Quick-drying hand disinfection emulsion |
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