CN102246793B - A kind of composition of killing microorganisms and application thereof - Google Patents
A kind of composition of killing microorganisms and application thereof Download PDFInfo
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Abstract
The object of the present invention is to provide one to have formula simple, the composition of the killing microorganisms that cost is low, under the prerequisite ensureing bactericidal effect, the bactericidal active ingredient compared with low dosage can be used; Another object of the present invention is to provide the new opplication of a kind of Chemical composition that in preparation killing microorganisms product; The invention discloses the application of Chemical composition that in preparation killing microorganisms product containing ethanol, poly hexamethylene biguanide (PHMB) or its salt, isopropyl alcohol composition, wherein the weight ratio sum of ethanol and isopropyl alcohol is no more than 48% ~ 80%.
Description
Technical field
The present invention relates to a kind of Chemical composition that and the application of said composition in preparation killing microorganisms product of killing microorganisms.
Background technology
Due to increasing the weight of of global warming and environmental pollution, the variation of pathogenic microorganisms is accelerated; The abuse of various antibiotic, antiviral drugs; to the virus of antibiotic and the immunity of enantiopathy cytotoxic drug; and the generation of the pathogenic microorganisms of highly pathogenic highly infective is also in quickening; reply and control caused by pathogenic microorganisms infectious disease break out with popular; just must control source of infection, cut off route of transmission and protection susceptible person; wherein, cutting off route of transmission is safe and reliable important means.
Methylguanidine in poly hexamethylene biguanide (PHMB) compound has very high activity, easily by bacterium, virus adsorb, directly act on microorganism, inhibit the division copy function of bacterium, virus, it plugs the respiration channel of microorganism in the formation of microorganism body surface polymer, and microorganism is choked to death.Meanwhile, its high molecular polymer structure makes the effective active of guanidine radicals be improved, and bacterium not easily produces drug resistance.
This compound, in the systematic Study of European medicine industry by the research of the research of the studies on acute toxicity of system, human body toxicological study, Study on Subchronic, chronic toxicity and carcinogenic possibility, genotoxicity, reviviscence toxicity research and metabolism, finally draws hexamethylene systematic toxicology conclusion: 1. low acute toxicity; 2. when when normal using dosage, there is low skin and eye irritation; 3. low long-term toxicity; 4. without genotoxicity; 5. non-teratogenesis; 6. proved without reviviscence toxicity by the research between two generations; 7. for the mankind, non-carcinogenic potential drug is belonged to.
The bactericidal mechanism of ethanol, isopropyl alcohol, mainly by the lipid in removing Knowledge On Bacterial Biofilm, makes microorganism protein denaturation solidify and plays sterilization or bacteriostasis, be widely used in sterilization field.
Above-mentioned composition is good fit, plays synergy, can obtain better bactericidal effect in the shorter time.
At present, Chinese patent literature has disclosed many antimicrobial products, and wherein part has selected alcohols, polymerization guanidine class etc. to be bactericidal active ingredient.
Application number is the patent application document of 200910114010.7, disclose a kind of by polyhexamethylene hydrochloric acid biguanides and ethanol be major antibacterial active ingredient, polyoxyethylene nonylphenol ether is the skin degerming product of surfactant; Application number is the Chinese patent application file of 03139745.x, discloses a kind of sterile products be made up of 95% ethanol, poly hexamethylene biguanide, flavouring agent, water surplus; Application number is the Chinese patent application file of 200680032102.5, discloses a kind of by poly hexamethylene biguanide, secondary antimicrobial, and optional organic acid, process auxiliary agent is as the antimicrobial compositions of alcohol and surfactant composition; Application number is the Chinese patent application file of 200910114009.4, disclose a kind of formula of liquid disinfectant, with PHMB (also known as poly hexamethylene biguanide) for principle active component, select polyoxyethylene nonylphenol ether to be surfactant, add essence and make.
More than invent, be all difficult ethanol, poly hexamethylene biguanide or its salt, isopropyl alcohol three composition as the antimicrobial products of bactericidal active ingredient.
Application number is the Chinese patent application file of 200980108019.5, disclose a kind of alcohol antimicrobial skin sanitizing compositions comprising cationic compatible thickeners, it comprises alcohol, thickened systems (being substantially free of cellulosic polymer, based on the polymer of acrylate or its composition), cationic compound (as poly hexamethylene biguanide) etc. for skin conditioning benefits at least about 60%.The present invention and its difference are, thickened systems can not be used, meet more product demand, or use different thickened systems, the thickener that appropriate interpolation is as common in Hydroxypropyl methylcellulose etc., object is to extend drying time, makes product in article surface film forming, there is provided stronger fungicidal effectiveness, the longer antibacterial time.
Summary of the invention
The object of the present invention is to provide a kind of formula simple, the killing microorganisms composition that cost is low; There is the advantage that has a broad antifungal spectrum, speed of action are fast; Another object of the present invention is to provide the new opplication of a kind of Chemical composition that in preparation killing microorganisms product.
The present invention relates to the application of feedstock composition in preparation killing microorganisms product containing poly hexamethylene biguanide (PHMB) or its salt, isopropyl alcohol.
Composition of the present invention can also add ethanol; Or adding thickener, thickener is only limitted to cellulosic polymer or based on the polymer of acrylate or its composition.
The percentage by weight sum of ethanol of the present invention and isopropyl alcohol more than 48%, preferably 48% ~ 80%, more preferably 48% ~ 70%, most preferably 48% ~ 60%.
The percentage by weight of poly hexamethylene biguanide of the present invention or its salt for being no more than 12.5%, preferably 0.005% ~ 10%,
More preferably 0.01% ~ 2%.
This Chemical composition that can be independent or add acceptable auxiliary material, base material, make required antimicrobial products.
Thickener can add the HPMC of 0.01% ~ 1% as thickener, extends the drying time of composition, makes product in article surface film forming, provide stronger fungicidal effectiveness, the longer antibacterial time.
Advantage of the present invention is:
1, raw material is simple, and cost is low;
2, bactericidal effect is good, has a broad antifungal spectrum, and speed of action is fast, is particularly suited for the Quick disinfection of hand, skin, and effect 1min can reach sterilization requirement;
3, in composition, ethanol, isopropyl alcohol are volatile component, can be used for disposable formula.
With the product that said composition is made, can extensive, safe, practically for the sterilization of hand, skin, mucous membrane, the occasions such as family, restaurant, hotel, public transport, kindergarten, hospital comprise the sterilization, air sterillization, pet sterilization etc. of food kitchenware at interior general article surface.
Essence for a better understanding of the present invention, will illustrate that by the anti-microbial test result of ethanol, hexamethylene, isopropyl alcohol example combinations it is preparing the new opplication in antimicrobial products below.It is generally acknowledged, total alcohol amount is higher, and anti-microbial effect is stronger.
One, the Germicidal test of composition of the present invention
1, materials and methods
The active ingredient of 1.1 tests sample (liquid preparation) and content: hexamethylene content 0.3%, ethanol content 44%, isopropyl alcohol 4%.
1.2 test strains:
Escherichia coli (8099)
Staphylococcus aureus (ATCC 6538)
Pseudomonas aeruginosa (ATCC 15442)
Candida albicans (ATCC 10231)
Influenza virus (H
3n
2)
1.3 test basis:
Respective specified in Ministry of Public Health's " disinfection technology standard ".
2, result of the test
2.1 pairs of colibacillary sterilize experiment
Under test temperature is 20 DEG C ± 1 DEG C condition, prove through 3 repeated tests, test sample stoste effect 1.0min, to the average kill oncomelania >5.00 of Escherichia coli.(the results are shown in Table 1)
Table 1 is to colibacillary killing effect
。
The sterilize experiment of 2.2 pairs of staphylococcus aureuses
Under test temperature is 20 DEG C ± 1 DEG C condition, prove through 3 repeated tests, test sample stoste effect 1.0min, to the average kill oncomelania >5.00 of staphylococcus aureus.(the results are shown in Table 2)
The killing effect of table 2 pair staphylococcus aureus
。
The sterilize experiment of 2.3 pairs of pseudomonas aeruginosas
Under test temperature is 20 DEG C ± 1 DEG C condition, prove through 3 repeated tests, test sample stoste effect 1.0min, to the average kill oncomelania >5.00 of pseudomonas aeruginosa.(the results are shown in Table 3)
The killing effect of table 3 pair pseudomonas aeruginosa
。
The sterilize experiment of 2.4 pairs of Candida albicanss
Under test temperature is 20 DEG C ± 1 DEG C condition, prove through 3 repeated tests, test sample stoste effect 1.0min, to the average kill oncomelania >4.00 of Candida albicans.(the results are shown in Table 4)
The killing effect of table 4 pair Candida albicans
。
The inactivation test of 2.5 infected by influenzas
Under test temperature is 20 DEG C ± 1 DEG C condition, prove through 3 repeated tests, test sample stoste effect 1.0min, the average kill oncomelania >4.00 of infected by influenza.(the results are shown in Table 5)
The inactivating efficacy of table 5 infected by influenza
Note: positive control average log value and scope 4.32(4.23-4.50).
Two, the sterilization field trial of composition of the present invention
1, materials and methods
The active ingredient of 1.1 tests sample (liquid preparation) and content: hexamethylene content 0.3%, ethanol content 44%, isopropyl alcohol 4%.
1.2 test strains: natural bacteria.
1.3 dilutions: the phosphate buffer (PBS) of 0.1% Tween-80, pH value 7.2 ~ 7.4.
1.4 neutralizers: the phosphate buffer (PBS) of 5.0% Tween-80 and 5g/L lecithin.
1.5 test basis:
Respective specified in Ministry of Public Health's " disinfection technology standard ".
1.6 test method
1.6.1 hand-wrist bones field trial
After the mutual rubbing of experimenter's both hands, the five fingers close up, and bedew in containing the test tube of 10ml dilution with sterile cotton swab, come and go wiping 2 times to its left hand the five fingers face of counting on one's fingers from finger tip to finger root, sampling end is cut into former dilution in vitro, as positive controls in sterile working mode.After sampling, get test sample stoste, after skin wiping sterilization 1min, bedew in the test tube containing 10ml neutralizer solution with sterile cotton swab, its right hand same procedure is sampled, as sterilization group.Control group and sterilization group sample liquid are fully beaten and draws 1.0ml with acceptable diluent degree and inoculate plate, in duplicate, tryptose soya agar medium (TSA) is poured into after each group of inoculation plate, together with nonvaccinated test culture medium flat plate after condensation, put in 37 DEG C of incubators and cultivate 48h, counting surviving colonies number, calculates kill oncomelania.
1.6.2 skin degerming field trial
Before sterilization, after the mutual fully rubbing in inner forearm stage casing, experimenter left and right, dimension board is put in section surface in inside experimenter's left forearm, bedew, after drying on tube wall, in the region that dimension board is confined in containing the test tube of 10ml dilution with sterile cotton swab, lateral shuttle embrocates 10 times, longitudinal double rub 3 times, often embrocates one time, cotton swab is rotated one time.Sampling end is cut into former dilution in vitro, as positive controls in sterile working mode.After sampling, get test sample stoste, after skin wiping sterilization 1min, bedew in containing 10ml neutralizer solution test tube with sterile cotton swab, its right forearm same procedure is sampled, as experimental group.Control group and sterilization group sample liquid are fully beaten and draws 1.0ml with acceptable diluent degree and inoculate plate, in duplicate, tryptose soya agar medium (TSA) is poured into after each group of inoculation plate, together with nonvaccinated test culture medium flat plate after condensation, put in 37 DEG C of incubators and cultivate 48h, counting surviving colonies number, calculates kill oncomelania.
2, result of the test
2.1 hand-wrist bones field trials
Through 30 person-times of repeated tests, test sample stoste effect 1min, to the average kill oncomelania >1.00(of the natural bacteria on hand surface in table 6).
Table 6 hand-wrist bones site test results
。
2.2 skin degerming field trials
Through 30 person-times of repeated tests, test sample stoste effect 1min, to the average kill oncomelania >1.00(of the natural bacteria of skin surface in table 7).
Table 7 skin degerming site test results
Embodiment
Further illustrate technical solution of the present invention below in conjunction with specific embodiment, these embodiments can not be interpreted as it is restriction to technical solution.
Embodiment 1
Prepare thimerosal according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol (volume ratio is added successively under stirring, being converted into mass ratio is 92.3%, 445kg, isopropyl alcohol 39kg, glycerine 10kg, hypromellose cellulose solution down together), finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
Wherein, glycerine has the effect of moisturizing skin care, can slow down the stimulation of alcohols solvent to skin, meanwhile, can extend drying time, strengthens antibacterial effect; HPMC can make this thimerosal in skin and article surface film forming, extends the antibacterial time; Bronopol uses used as stabilizers in this product.
Stability meets the requirement of Ministry of Health of the People's Republic of China's " disinfection technology standard " (version in 2002), the term of validity 24 months.
Through inspection, to chmice acute per os LD
50> 5000 mg/kg body weight, true border is nontoxic; Repeatedly intact skin irritant test total mark mean value is 0, skin irritation index < 0.5, and stimulus intensity belongs to nonirritant; To PCEMNR without causing micronucleus effect; Maximum illeffects dosage of not observing is 1000 mg/kg body weight.
In said composition, ethanol content by weight 45.6%, isopropyl alcohol 4.3%, hexamethylene 0.33%.
Embodiment 2
The thimerosal prepared, with example 1, is adsorbed in non-woven fabrics as wet tissue annex solution, makes wet sanitary napkins by the preparation method of this sanitizing composition.
After testing, under 20 DEG C ± 1 DEG C condition, wet sanitary napkins effect 1 min, 100% is to colibacillary average kill ratio, 100% is to the average kill ratio of staphylococcus aureus, 100% is to the average kill ratio of pseudomonas aeruginosa, be 99.94% to the average kill ratio of hemolytic streptococcus, be 99.91% to the average kill ratio of Candida albicans, the average kill oncomelania > 3.00 of infected by influenza, to the deactivation logarithm value > 3.00 of HIV virus.
Hand-wrist bones field trial: through 30 person-times of repeated tests, wet sanitary napkins effect 1min, to the average kill oncomelania > 1.00 of the natural bacteria on hand surface.
Escherichia coli Simulation field trial: prove through 30 sampling tests, pollutes colibacillary body surface 1min with wet sanitary napkins wiping, and the Escherichia coli average kill ratio polluted body surface is 100%.
Keep the condition of >=75% in relative moisture under, after placing 14 days (be equivalent to room temperature and place 1 year) in 54 DEG C of insulating boxs, wet sanitary napkins effect 1min is still 100% to colibacillary average kill ratio.
Embodiment 3
Prepare thimerosal according to following steps: in stainless steel cask, add the hot purified water of 20L, be weighed into Hydroxypropyl methylcellulose 0.5kg and be stirred to transparent clarification.95% ethanol 824kg is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 5kg, isopropyl alcohol 39kg, glycerine 1kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, qualified rear packing.
The thimerosal prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet sanitary napkins.
Embodiment 4
Prepare thimerosal according to following steps: in stainless steel cask, add the hot purified water of 20L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.95% ethanol 770kg is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 5kg, isopropyl alcohol 39kg, glycerine 10kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, qualified rear packing.
The thimerosal prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet sanitary napkins.
Embodiment 5
Spray is prepared: in preparing tank, add 10L purified water according to following steps, bronopol 0.3kg, 20% hexamethylene aqueous solution 0.25kg, 95% ethanol 658kg, isopropyl alcohol 39kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 6
Wet mop towel is prepared: in preparing tank, add 10L purified water according to following steps, bronopol 0.2kg, 20% hexamethylene aqueous solution 0.5kg, 95% ethanol 690kg, isopropyl alcohol 80kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, be qualifiedly adsorbed in non-woven fabrics as wet mop towel annex solution afterwards, make wet mop towel.
Embodiment 7
Wet mop towel is prepared: in preparing tank, add 20% hexamethylene aqueous solution 100kg according to following steps, bronopol 0.4kg, 95% ethanol 658kg, isopropyl alcohol 39kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, be qualifiedly adsorbed in non-woven fabrics as wet mop towel annex solution afterwards, make wet mop towel.
Embodiment 8
Wet mop towel is prepared: in preparing tank, add 20% hexamethylene aqueous solution 500kg according to following steps, bronopol 0.6kg, 95% ethanol 10kg, isopropyl alcohol 480kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, be qualifiedly adsorbed in non-woven fabrics as wet mop towel annex solution afterwards, make wet mop towel.
Embodiment 9
Prepare thimerosal according to following steps: in stainless steel cask, add the hot purified water of 10L, be weighed into Hydroxypropyl methylcellulose 0.2kg and be stirred to transparent clarification.20L purified water is added in preparing tank, bronopol 0.5kg, 20% hexamethylene aqueous solution 16.5kg, 95% ethanol 465kg, isopropyl alcohol 195kg, Sensiva SC50 (a kind of 1-alkyl glycerol ether compound) 10kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The thimerosal prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet sanitary napkins.
Embodiment 10
Prepare thimerosal according to following steps: in stainless steel cask, add the hot purified water of 10L, be weighed into Hydroxypropyl methylcellulose 0.7kg and be stirred to transparent clarification.20L purified water is added in preparing tank, bronopol 0.8kg, the 20% hexamethylene aqueous solution 22.5 kg, 95% ethanol 560kg, isopropyl alcohol 154kg, glycerine 8kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, qualified rear packing.
The thimerosal prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet sanitary napkins.
Embodiment 11
Prepare thimerosal according to following steps: in stainless steel cask, add the hot purified water of 20L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.20L purified water is added in preparing tank, bronopol 0.9kg, the 20% hexamethylene aqueous solution 15.5 kg, 95% ethanol 550 kg, isopropyl alcohol 40 kg, Sensiva SC50 (a kind of 1-alkyl glycerol ether compound) 10kg, ethohexadiol 3kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, qualified rear packing.
The thimerosal prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet sanitary napkins.
Embodiment 12
Thimerosal is prepared: in preparing tank, add 20L purified water according to following steps, bronopol 1.0kg, 20% hexamethylene aqueous solution 3kg, 95% ethanol 563kg, isopropyl alcohol 180kg, glycerine 6kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, qualified rear packing.
The thimerosal prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet sanitary napkins.
Embodiment 13
Thimerosal is prepared: in preparing tank, add 20L purified water according to following steps, bronopol 0.3kg, 20% hexamethylene aqueous solution 20kg, 95% ethanol 534kg, isopropyl alcohol 51 kg, glycerine 5kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, qualified rear packing.
The thimerosal prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet sanitary napkins.
Embodiment 14
Thimerosal is prepared: in preparing tank, add 20L purified water according to following steps, 20% hexamethylene aqueous solution 10kg, 95% ethanol 563kg, isopropyl alcohol 33kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, qualified rear packing.
The thimerosal prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet sanitary napkins.
Embodiment 15
Aerosol is prepared: in preparing tank, add 20L purified water according to following steps, bronopol 0.5kg, the 20% hexamethylene aqueous solution 0.5 kg, 95% ethanol 506 kg, isopropyl alcohol 154 kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes, be sealed in pressure vessel, refilled a certain amount of propellant.
Embodiment 16
According to following steps preparation sterilization spray: add 20L purified water in preparing tank, bronopol 0.6kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 558 kg, isopropyl alcohol 54 kg, PPG-20 methyl ether (a kind of glucosan derivative) 50 kg are added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 17
According to following steps preparation sterilization spray: add 20L purified water in preparing tank, bronopol 0.6kg, 20% hexamethylene aqueous solution 2kg, 95% ethanol 578kg, isopropyl alcohol 40kg, extract solution from aloe 1 kg, glycerine 2 kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 18
Wet wiping towel is prepared: in preparing tank, add 20L purified water according to following steps, bronopol 0.7kg, 20% hexamethylene aqueous solution 4kg, 95% ethanol 490kg, isopropyl alcohol 150kg, jojoba oil 2 kg, marine algae extract 1 kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.The liquid prepared is adsorbed in non-woven fabrics as wet wiping towel annex solution, makes wet wiping towel.
Embodiment 19
Wet wiping towel is prepared: in preparing tank, add 20L purified water according to following steps, bronopol 0.3kg, 20% hexamethylene aqueous solution 5kg, 95% ethanol 525kg, isopropyl alcohol 15kg, hyaluronic acid 5 kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.The liquid prepared is adsorbed in non-woven fabrics as wet wiping towel annex solution, makes wet wiping towel.
Embodiment 20
According to following steps preparation sterilization spray: add 20L purified water in preparing tank, bronopol 0.5kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 540kg, isopropyl alcohol 39kg, shitosan 10 kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 21
Thimerosal is prepared: in preparing tank, add 20L purified water according to following steps, bronopol 0.1kg, 20% hexamethylene aqueous solution 35kg, 95% ethanol 684kg, isopropyl alcohol 12kg, Cer EOS kg, glycerine 2kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, qualified rear packing.
The thimerosal prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet sanitary napkins.
Embodiment 22
Prepare gel according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into hydroxyethylcellulose 150kg and be stirred to transparent clarification.100L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 12kg, 95% ethanol 490kg, isopropyl alcohol 28kg, glycerine 9kg, hydroxyethyl cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, qualified rear packing.
Embodiment 23
Thimerosal is prepared: in preparing tank, add 20L purified water according to following steps, bronopol 0.6kg, 20% hexamethylene aqueous solution 13kg, 95% ethanol 200kg, isopropyl alcohol 330kg, glycerine 7kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, qualified rear packing.
The thimerosal prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet sanitary napkins.
Embodiment 24
Wet mop towel is prepared: in preparing tank, add 20% hexamethylene aqueous solution 100kg according to following steps, bronopol 0.4kg, isopropyl alcohol 658kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, be qualifiedly adsorbed in non-woven fabrics as wet mop towel annex solution afterwards, make wet mop towel.
Claims (11)
1. a composition for killing microorganisms, is characterized in that: the percentage by weight containing poly hexamethylene biguanide (PHMB) or its salt is 0.005% ~ 10%, the percentage by weight sum of ethanol and isopropyl alcohol is more than 48%.
2. composition according to claim 1, is characterized in that: the percentage by weight sum of ethanol and isopropyl alcohol is 48% ~ 80%.
3. composition according to claim 2, is characterized in that: the percentage by weight sum of ethanol and isopropyl alcohol is 48% ~ 70%.
4. composition according to claim 3, is characterized in that: the percentage by weight sum of ethanol and isopropyl alcohol is 48% ~ 60%.
5. composition according to claim 1, is characterized in that: the percentage by weight of poly hexamethylene biguanide or its salt is 0.01% ~ 2%.
6. the arbitrary described composition of claim 1-5, is characterized in that: the percentage by weight of poly hexamethylene biguanide or its salt is 0.33%, the percentage by weight of ethanol is 45.6%, the percentage by weight of isopropyl alcohol is 4.3%.
7. the arbitrary described composition of claim 1-5, is characterized in that: the percentage by weight of poly hexamethylene biguanide or its salt is 0.3%, the percentage by weight of ethanol is 44%, the percentage by weight of isopropyl alcohol is 4%.
8. claim 1-5 arbitrary described or 6 or 7 composition, it is characterized in that: can also add thickener, thickener is only limitted to cellulosic polymer or based on the polymer of acrylate or its composition.
9. composition according to claim 8, is characterized in that: thickener is the HPMC of 0.01% ~ 1%.
10. the application of the arbitrary described composition of claim 1-9 in preparation killing microorganisms product.
The arbitrary described composition of 11. claim 1-9 adds auxiliary material, base material, makes required antimicrobial products.
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| CN111773241A (en) * | 2020-07-21 | 2020-10-16 | 贵州威克斯医疗科技有限公司 | Composition containing PHMB for preventing and relieving diaper eczema |
| CN111851071B (en) * | 2020-07-27 | 2023-04-28 | 广东德美精细化工集团股份有限公司 | Antiviral finishing agent and preparation method and application thereof |
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